Database : MEDLINE
Search on : cinnamates [Words]
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[PMID]: 29428241
[Au] Autor:Durant-Archibold AA; Santana AI; Gupta MP
[Ad] Address:Biochemistry and Molecular Medicine Research Unit, Center for Drug Discovery and Biodiversity Institute of Scientific Research and High Technology Services (INDICASAT, AIP), Panama City, Panama; College of Natural, Exact Sciences and Technology, University of Panama, Panama City, Panama. Electronic address: adurant@indicasat.org.pa.
[Ti] Title:Ethnomedical uses and pharmacological activities of most prevalent species of genus Piper in Panama: A review.
[So] Source:J Ethnopharmacol;217:63-82, 2018 Feb 09.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Piperaceae is the fifth largest family of plants in Panama. This review focuses on the ethnomedical uses of the most prevalent Panamanian species and biological activities of their extracts and/or constituents both in Panama and worldwide. Many species have a plethora of ethnomedical uses such as antibacterial, antifungal, anti-inflammatory, anticancer, antidiabetic, anti-Helicobacter pylori, antiulcer, antiprotozoal, estrogenic, insecticidal, local anesthetic, diuretic, and for women's health conditions. AIM OF THE REVIEW: The aim of this review is to compile all ethnomedical uses of most prevalent species of Piper in Panama, and their extracts or phytoconstituents worldwide, through a complete literature search, so that it may allow selection of potential unexplored Piper species for future research and development of phytotherapeuticals for important ailments. METHODOLOGY: This review conducted a thorough search in books and databases such as Google Scholar, PubMed, Sci-Finder, Scopus, ACS publications, Science Direct, and Reaxys (Elsevier), until October of 2017. The information provided in this review is based on peer-reviewed papers only in English. The key words used to search were: "Piper", "Piperaceae", "Panama", "Pharmacological activity", "Chemistry," "Toxicity," and "Clinical studies". Scientific names of the plants were validated through www.tropicos.org. Potential full-texts of eligible papers, irrespective of database, were identified. Study selection and data extraction were conducted by one author (AIS) and confirmed by others (MPG, ADA). The extracted data were summarized in tabular form and a narrative description was used to provide a summary of updated information. RESULTS: The ethnomedical uses of most prevalent 23 Panamanian species of Piper both in Panama as well in the world are provided. Of these species only Piper arboreum, Piper auritum, Piper cordulatum, Piper hispidum, Piper dariense, Piper multiplinervium and Piper umbellatum have ethnomedical uses in Panama. Some of the uses are by native Amerindians of Panama. These include ailments such as liver pains, common colds, skin infections, insecticidal, as a bath to alleviate colds, snakebites, different types of pains, skin ailments, wound healing, rheumatism, women's health, antipyretic, and anti-inflammatory. Other Panamanian species are widely used in many countries of the world. Of all the Piper species, P. aduncum has the most ethnomedical uses. Panamanian uses are different from the ones in other countries. A total of 61 compounds present in Piper species reported in this review have shown a variety of biological activities in vitro. These compounds belong to different chemical types, such as chromenes, amides, alkaloids, benzopyrans, benzoates, essential oils, pyrrolidines, flavokaines, chalcones, methylenedioxy propiophenones, cinnamates, monoterpenes, sesquiterpenes, phenols, among others. From this review it is evident that extracts and pure compounds isolated from Piper species have shown a wide array of mainly in vitro activity and some ethnomedical uses may be correlated with their activities reported. CONCLUSIONS: Plants of this genus have provided bioactive species, both from crude extracts and pure compounds thus substantiating their efficacy in traditional medicine. In vivo and toxicological studies are still limited, but the results of different activities of Piper reported point out the great potential of these species for obtaining bioactive principles that may be useful in treating diseases. However, a thorough investigation of Piper species relating to chemistry, in vivo pharmacological activities, with emphasis on their mechanism of action, safety and efficacy and toxicity is warranted.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher

  2 / 5105 MEDLINE  
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[PMID]: 29457733
[Au] Autor:Qi J; Zheng J; Cui S
[Ad] Address:Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, China.
[Ti] Title:Fe(III)-Catalyzed Hydroallylation of Unactivated Alkenes with Morita-Baylis-Hillman Adducts.
[So] Source:Org Lett;20(5):1355-1358, 2018 Mar 02.
[Is] ISSN:1523-7052
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:An Fe(III)-catalyzed hydroallylation of unactivated alkenes with Morita-Baylis-Hillman adducts via an Fe-catalyzed process is described. A variety of alkenes, including mono-, di-, and trisubstituted alkenes, could all smoothly convert to structural diversified cinnamates in this protocol. Interestingly, when the hydroxyl-containing alkenes were used, various lactones could be rapidly assembled. Moreover, this protocol could be applied to late-stage functionalization of natural products.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Data-Review
[do] DOI:10.1021/acs.orglett.8b00108

  3 / 5105 MEDLINE  
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[PMID]: 28637122
[Au] Autor:Wang ZG; Mi J; Wang XR; Huo YY; Peng YJ; Zhang HM; Gao Y; Zhang HL
[Ad] Address:a Department of Pharmaceutical Analysis , Heilongjiang University of Chinese Medicine , Harbin , China.
[Ti] Title:A new cinnamic acid glycoside from roots of Heracleum dissectum.
[So] Source:Nat Prod Res;32(2):133-140, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:From the roots of Heracleum dissectum Lebb., one new cinnamic acid glycoside derivative named dissectumoside (1), together with eight known compounds including three phenolics, three phenolic glycosides and two phenylpropanoic glycoside were isolated using various chromatographic methods. Among them compound 2-9 was isolated from the plant for the first time. Their structures were elucidated and identified on the basis of their physicochemical properties and by extensive analyses of NMR spectroscopy and high-resolution mass spectrometry. The results of triglyceride accumulation screening in 3T3-L1 cells showed that compounds 1, 5 and 9 exhibited significantly accelerating activities of adipogenesis in adipocytes.
[Mh] MeSH terms primary: Cinnamates/isolation & purification
Glycosides/isolation & purification
Heracleum/chemistry
Plant Extracts/chemistry
[Mh] MeSH terms secundary: 3T3-L1 Cells
Adipocytes/drug effects
Adipogenesis/drug effects
Animals
Cardiac Glycosides
Cinnamates/chemistry
Glycosides/chemistry
Mice
Phenols/chemistry
Plant Roots/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cardiac Glycosides); 0 (Cinnamates); 0 (Glycosides); 0 (Phenols); 0 (Plant Extracts); U14A832J8D (cinnamic acid)
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[Js] Journal subset:IM
[Da] Date of entry for processing:170623
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1340285

  4 / 5105 MEDLINE  
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[PMID]: 29345918
[Au] Autor:Villalva M; Jaime L; Aguado E; Nieto JA; Reglero G; Santoyo S
[Ad] Address:Institute of Food Science Research (CIAL), Universidad Autónoma de Madrid (CEI UAM + CSIC) , 28049 Madrid, Spain.
[Ti] Title:Anti-Inflammatory and Antioxidant Activities from the Basolateral Fraction of Caco-2 Cells Exposed to a Rosmarinic Acid Enriched Extract.
[So] Source:J Agric Food Chem;66(5):1167-1174, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The potential use of Origanum majorana L. as a source of bioavailable phenolic compounds, specifically rosmarinic acid (RA), has been evaluated. Phenolic bioavailability was tested using an in vitro digestion process followed by a Caco-2 cellular model of intestinal absorption. The high-performance liquid chromatography-photodiode array detector-tandem mass spectrometry (HPLC-PAD-MS/MS) analysis showed the main components in the extract were 6-hydroxyluteolin-7-O-glucoside and rosmarinic acid, followed by luteolin-O-glucoside. After digestion process, the amount of total phenolic compounds (TPC) only decreased slightly, although a remarkable reduction in RA (near 50%) was detected. Bioavailable fraction contained 7.37 ± 1.39 mg/L digested extract of RA with small quantities of lithospermic acid and diosmin and presented an important antioxidant activity (0.89 ± 0.09 mmol Trolox/L digested extract). Besides, this bioavailable fraction produced a significant inhibition in TNF-α, IL-1ß, and IL-6 secretion, using a human THP-1 macrophages model. Therefore, RA content in the basolateral compartment could play an important role in the antioxidant and anti-inflammatory activities found.
[Mh] MeSH terms primary: Anti-Inflammatory Agents
Antioxidants
Cinnamates/pharmacology
Depsides/pharmacology
Origanum/chemistry
Plant Extracts/chemistry
Plant Extracts/pharmacology
[Mh] MeSH terms secundary: Biological Availability
Caco-2 Cells
Cinnamates/analysis
Cinnamates/pharmacokinetics
Depsides/analysis
Depsides/pharmacokinetics
Humans
Intestinal Absorption
Phenols/pharmacokinetics
Plant Extracts/pharmacokinetics
Plant Leaves/chemistry
THP-1 Cells
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cinnamates); 0 (Depsides); 0 (Phenols); 0 (Plant Extracts); MQE6XG29YI (rosmarinic acid)
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[Js] Journal subset:IM
[Da] Date of entry for processing:180119
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b06008

  5 / 5105 MEDLINE  
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[PMID]: 29351879
[Au] Autor:Szopa A; Starzec A; Ekiert H
[Ad] Address:Chair and Department of Pharmaceutical Botany, Jagiellonian University, Collegium Medicum, ul. Medyczna 9, 30-688 Kraków, Poland. Electronic address: a.szopa@uj.edu.pl.
[Ti] Title:The importance of monochromatic lights in the production of phenolic acids and flavonoids in shoot cultures of Aronia melanocarpa, Aronia arbutifolia and Aronia נprunifolia.
[So] Source:J Photochem Photobiol B;179:91-97, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Shoot cultures of Aronia melanocarpa, A. arbutifolia and A. × prunifolia were maintained on Murashige and Skoog medium with 1 mg/l each of BA and NAA under monochromatic lights (far-red, red, blue lights, UV-A-irradiation), in darkness, and under white light (control). HPLC-DAD analyses of 19 phenolic acids and 11 flavonoids in methanolic extracts from the shoots revealed in all of them the presence of three depsides (chlorogenic, neochlorogenic and rosmarinic acids), protocatechuic acid, four flavonoid glycosides (cynaroside, quercitrin, hyperoside and rutoside), and additionally, in A. arbutifolia, 3,4-dihydroxyphenylacetic acid. Depending on light quality, the total amounts of these metabolites increased 1.8-5.9 times, reaching maximum values under blue light: 527.40 and 144.61 mg 100 g DW (A. melanocarpa), 543.27 and 85.82 mg 100 g DW (A. arbutifolia) and 1615.18 and 220.65 mg 100 g DW (A. × prunifolia), respectively. The maximum total amounts were 1.3-3.6 times higher than under white light. The quantities of individual metabolites changed from 1.2 to 11.0 times, with high amounts of neochlorogenic acid and quercitrin in A. melanocarpa (243.35 and 75.64 mg 100 g DW), and of chlorogenic and rosmarinic acids and quercitrin in A. arbutifolia (236.52, 219.35 and 51.01 mg 100 g DW). Extremely high amounts of depsides (418.83, 644.68, 548.86 mg 100 g DW) and quercitrin (165.88 mg 100 g DW) were produced in cultures of the hybrid - A. × prunifolia. The results are potentially useful for practical applications. This is the first report documented the importance of light quality on the production of phenolic acids and flavonoids in three aronia in vitro cultures.
[Mh] MeSH terms primary: Flavonoids/metabolism
Hydroxybenzoates/metabolism
Light
Photinia/radiation effects
[Mh] MeSH terms secundary: Biomass
Chlorogenic Acid/analysis
Chlorogenic Acid/metabolism
Chromatography, High Pressure Liquid
Cinnamates/analysis
Cinnamates/metabolism
Depsides/analysis
Depsides/metabolism
Flavonoids/analysis
Hydroxybenzoates/analysis
Photinia/chemistry
Photinia/metabolism
Plant Shoots/chemistry
Plant Shoots/metabolism
Plant Shoots/radiation effects
Quercetin/analogs & derivatives
Quercetin/analysis
Quercetin/metabolism
Ultraviolet Rays
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cinnamates); 0 (Depsides); 0 (Flavonoids); 0 (Hydroxybenzoates); 29656-58-4 (phenolic acid); 2Y8906LC5P (quercitrin); 318ADP12RI (Chlorogenic Acid); 9IKM0I5T1E (Quercetin); MQE6XG29YI (rosmarinic acid)
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[Js] Journal subset:IM
[Da] Date of entry for processing:180121
[St] Status:MEDLINE

  6 / 5105 MEDLINE  
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[PMID]: 29314866
[Au] Autor:Herrlinger KA; Nieman KM; Sanoshy KD; Fonseca BA; Lasrado JA; Schild AL; Maki KC; Wesnes KA; Ceddia MA
[Ad] Address:1 Kemin Foods, LC , Des Moines, IA.
[Ti] Title:Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment.
[So] Source:J Altern Complement Med;24(1):37-47, 2018 Jan.
[Is] ISSN:1557-7708
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The purpose of this study was to investigate the effects of supplementation with a spearmint (Mentha spicata L.) extract, high in polyphenols including rosmarinic acid, on cognitive performance, sleep, and mood in individuals with age-associated memory impairment (AAMI). DESIGN: Subjects with AAMI (N = 90; 67% female; age = 59.4 ± 0.6 years) were randomly assigned (n = 30/group) to consume 900, 600, or 0 mg/day (two capsules, once daily) spearmint extract for 90 days, in this double-blind, placebo-controlled trial. Assessments were completed for cognition (days 0, 45, and 90), sleep (days 0 and 90), and mood (days 0 and 90) by using the Cognitive Drug Research (CDR) System , Leeds Sleep Evaluation Questionnaire (LSEQ), and Profile of Mood States (POMS ), respectively. RESULTS: Quality of working memory and spatial working memory accuracy improved after supplementation with 900 mg/day spearmint extract by 15% (p = 0.0469) and 9% (p = 0.0456), respectively, versus placebo. Subjects consuming 900 mg/day spearmint extract reported improvement in their ability to fall asleep, relative to subjects consuming placebo (p = 0.0046). Overall treatment effects were evident for vigor-activity (p = 0.0399), total mood disturbance (p = 0.0374), and alertness and behavior following wakefulness (p = 0.0415), with trends observed for improvements after spearmint supplementation relative to placebo. CONCLUSIONS: These results suggest that the distinct spearmint extract may be a beneficial nutritional intervention for cognitive health in older subjects with AAMI.
[Mh] MeSH terms primary: Memory Disorders/drug therapy
Memory, Short-Term/drug effects
Plant Extracts/pharmacology
Plant Extracts/therapeutic use
[Mh] MeSH terms secundary: Cinnamates
Cognition/drug effects
Depsides
Female
Humans
Male
Mentha spicata
Middle Aged
Polyphenols
Sleep/drug effects
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Name of substance:0 (Cinnamates); 0 (Depsides); 0 (Plant Extracts); 0 (Polyphenols); MQE6XG29YI (rosmarinic acid)
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[Js] Journal subset:IM
[Da] Date of entry for processing:180110
[St] Status:MEDLINE
[do] DOI:10.1089/acm.2016.0379

  7 / 5105 MEDLINE  
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[PMID]: 29374707
[Au] Autor:Uesawa Y; Sakagami H; Okudaira N; Toda K; Takao K; Kagaya H; Sugita Y
[Ad] Address:Department of Clinical Pharmaceutics, Meiji Pharmaceutical University, Tokyo, Japan uesawa@my-pharm.ac.jp.
[Ti] Title:Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.
[So] Source:Anticancer Res;38(2):817-823, 2018 02.
[Is] ISSN:1791-7530
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:BACKGROUND/AIM: Many phenolic acid phenethyl esters possess diverse biological effects including antioxidant, cytoprotective, anti-inflammation and anti-tumor activities. However, most previous antitumor studies have not considered the cytotoxicity against normal cells. Ten cinnamic acid phenetyl esters were subjected to quantitative structure-activity relationship (QSAR) analysis, based on their cytotoxicity and tumor-specificity, in order to find their new biological activities. MATERIALS AND METHODS: Cytotoxicity against four human oral squamous cell carcinoma cell lines and three oral normal mesenchymal cells was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Tumor specificity (TS) was evaluated by the ratio of the mean 50% cytotoxic concentration (CC ) against normal oral cells to that against human oral squamous cell carcinoma cell lines. Potency-selectivity expression (PSE) value was calculated by dividing the TS value by CC against tumor cells. Apoptosis markers were detected by western blot analysis. Physicochemical, structural and quantum-chemical parameters were calculated based on the conformations optimized by force-field minimization. RESULTS: Western blot analysis demonstrated that [ ] stimulated the cleavage of caspase-3, suggesting the induction of apoptosis. QSAR analysis demonstrated that TS values were correlated with shape, size and ionization potential. CONCLUSION: Chemical modification of the lead compound may be a potential choice for designing a new type of anticancer drugs.
[Mh] MeSH terms primary: Cinnamates/pharmacology
Esters/pharmacology
Phenylethyl Alcohol/pharmacology
[Mh] MeSH terms secundary: Carcinoma, Squamous Cell/drug therapy
Carcinoma, Squamous Cell/pathology
Cell Line, Tumor
Child
Cinnamates/chemistry
Cinnamates/toxicity
Esters/chemistry
Esters/toxicity
Fibroblasts/drug effects
Head and Neck Neoplasms/drug therapy
Head and Neck Neoplasms/pathology
Humans
Male
Mouth Neoplasms/drug therapy
Mouth Neoplasms/pathology
Phenylethyl Alcohol/chemistry
Phenylethyl Alcohol/toxicity
Quantitative Structure-Activity Relationship
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cinnamates); 0 (Esters); ML9LGA7468 (Phenylethyl Alcohol); U14A832J8D (cinnamic acid)
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[Js] Journal subset:IM
[Da] Date of entry for processing:180129
[St] Status:MEDLINE

  8 / 5105 MEDLINE  
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[PMID]: 29447012
[Au] Autor:Gao X; Tang J; Liu H; Liu L; Kang L; Chen W
[Ad] Address:a Key Laboratory Breeding Base of Hu'nan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, College of Pharmacy , Changsha Medical University , Changsha , China.
[Ti] Title:Structure-activity relationship investigation of tertiary amine derivatives of cinnamic acid as acetylcholinesterase and butyrylcholinesterase inhibitors: compared with that of phenylpropionic acid, sorbic acid and hexanoic acid.
[So] Source:J Enzyme Inhib Med Chem;33(1):519-524, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In the present investigation, 48 new tertiary amine derivatives of cinnamic acid, phenylpropionic acid, sorbic acid and hexanoic acid (4d-6g, 10d-12g, 16d-18g and 22d-24g) were designed, synthesized and evaluated for the effect on AChE and BChE in vitro. The results revealed that the alteration of aminoalkyl types and substituted positions markedly influences the effects in inhibiting AChE. Almost of all cinnamic acid derivatives had the most potent inhibitory activity than that of other acid derivatives with the same aminoalkyl side chain. Unsaturated bond and benzene ring in cinnamic acid scaffold seems important for the inhibitory activity against AChE. Among them, compound 6g revealed the most potent AChE inhibitory activity (IC value: 3.64 µmol/L) and highest selectivity over BChE (ratio: 28.6). Enzyme kinetic study showed that it present a mixed-type inhibition against AChE. The molecular docking study suggested that it can bind with the catalytic site and peripheral site of AChE.
[Mh] MeSH terms primary: Amines/pharmacology
Caproates/pharmacology
Cholinesterase Inhibitors/pharmacology
Cinnamates/pharmacology
Phenylpropionates/pharmacology
Sorbic Acid/pharmacology
[Mh] MeSH terms secundary: Acetylcholinesterase/metabolism
Amines/chemical synthesis
Amines/chemistry
Animals
Butyrylcholinesterase/metabolism
Caproates/chemistry
Cholinesterase Inhibitors/chemical synthesis
Cholinesterase Inhibitors/chemistry
Cinnamates/chemistry
Dose-Response Relationship, Drug
Molecular Docking Simulation
Molecular Structure
Phenylpropionates/chemistry
Rats
Rats, Sprague-Dawley
Sorbic Acid/chemistry
Structure-Activity Relationship
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Amines); 0 (Caproates); 0 (Cholinesterase Inhibitors); 0 (Cinnamates); 0 (Phenylpropionates); 1F8SN134MX (hexanoic acid); 5Q445IN5CU (3-phenylpropionic acid); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase); U14A832J8D (cinnamic acid); X045WJ989B (Sorbic Acid)
[Em] Entry month:1802
[Cu] Class update date: 180219
[Lr] Last revision date:180219
[Js] Journal subset:IM
[Da] Date of entry for processing:180216
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2018.1436053

  9 / 5105 MEDLINE  
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[PMID]: 29232022
[Au] Autor:Gatzenmeier T; Kaib PSJ; Lingnau JB; Goddard R; List B
[Ad] Address:Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany.
[Ti] Title:The Catalytic Asymmetric Mukaiyama-Michael Reaction of Silyl Ketene Acetals with α,ß-Unsaturated Methyl Esters.
[So] Source:Angew Chem Int Ed Engl;57(9):2464-2468, 2018 Feb 23.
[Is] ISSN:1521-3773
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:α,ß-Unsaturated esters are readily available but challenging substrates to activate in asymmetric catalysis. We now describe an efficient, general, and highly enantioselective Mukaiyama-Michael reaction of silyl ketene acetals with α,ß-unsaturated methyl esters that is catalyzed by a silylium imidodiphosphorimidate (IDPi) Lewis acid.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180219
[Lr] Last revision date:180219
[St] Status:In-Data-Review
[do] DOI:10.1002/anie.201712088

  10 / 5105 MEDLINE  
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[PMID]: 29262714
[Au] Autor:Karadag B; Yücel NC
[Ad] Address:Department of Chemistry, Faculty of Science, Dokuz Eylul University , Buca, 35390, Izmir , Turkey.
[Ti] Title:Cinnamic acid and fish flour affect wheat phenolic acids and flavonoid compounds, lipid peroxidation, proline levels under salt stress.
[So] Source:Acta Biol Hung;68(4):388-397, 2017 Dec.
[Is] ISSN:0236-5383
[Cp] Country of publication:Hungary
[La] Language:eng
[Ab] Abstract:To elucidate the physiological mechanism of salt stress mitigated by cinnamic acid (CA) and fish flour (FF) pretreatment, wheat was pretreated with 20, 50 and 100 ppm CA and 1 g/10 mL FF for 2 d and was then cultivated. We investigated whether exogenous CA + FF could protect wheat from salt stress and examined whether the protective effect was associated with the regulation of seed vigor, antioxidant defense systems, phenolic biosynthesis and lipid peroxidation. At 2 days exogenous CA did not influence seed vigor. Salt stress increased the phenolic biosynthesis, but the CA + FF-combined pretreatment enhanced the phenolic biosynthesis even more under salt stress and decreased lipid peroxidation to some extent, enhancing the tolerance of wheat to salt stress.
[Mh] MeSH terms primary: Cinnamates/metabolism
Fish Flour
Flavonoids/metabolism
Hydroxybenzoates/metabolism
Lipid Peroxidation
Osmotic Pressure
Triticum/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cinnamates); 0 (Flavonoids); 0 (Hydroxybenzoates); 29656-58-4 (phenolic acid); U14A832J8D (cinnamic acid)
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:171222
[St] Status:MEDLINE
[do] DOI:10.1556/018.68.2017.4.5


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