Database : MEDLINE
Search on : coronary and stenosis [Words]
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[PMID]: 29511194
[Au] Autor:Helgadottir A; Thorleifsson G; Gretarsdottir S; Stefansson OA; Tragante V; Thorolfsdottir RB; Jonsdottir I; Bjornsson T; Steinthorsdottir V; Verweij N; Nielsen JB; Zhou W; Folkersen L; Martinsson A; Heydarpour M; Prakash S; Oskarsson G; Gudbjartsson T; Geirsson A; Olafsson I; Sigurdsson EL; Almgren P; Melander O; Franco-Cereceda A; Hamsten A; Fritsche L; Lin M; Yang B; Hornsby W; Guo D; Brummett CM; Abecasis G; Mathis M; Milewicz D; Body SC; Eriksson P; Willer CJ; Hveem K; Newton-Cheh C; Smith JG; Danielsen R; Thorgeirsson G; Thorsteinsdottir U; Gudbjartsson DF; Holm H; Stefansson K
[Ad] Address:deCODE genetics/Amgen Inc., Reykjavik, 101, Iceland. anna.helgadottir@decode.is.
[Ti] Title:Genome-wide analysis yields new loci associating with aortic valve stenosis.
[So] Source:Nat Commun;9(1):987, 2018 Mar 07.
[Is] ISSN:2041-1723
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR) = 1.20, P = 1.2 × 10 ) and on chromosome 2q22 in TEX41 (rs1830321; OR = 1.15, P = 1.8 × 10 ). Rs7543130 also associates with bicuspid aortic valve (BAV) (OR = 1.28, P = 6.6 × 10 ) and aortic root diameter (P = 1.30 × 10 ), and rs1830321 associates with BAV (OR = 1.12, P = 5.3 × 10 ) and coronary artery disease (OR = 1.05, P = 9.3 × 10 ). The results implicate both cardiac developmental abnormalities and atherosclerosis-like processes in the pathogenesis of AS. We show that several pathways are shared by CAD and AS. Causal analysis suggests that the shared risk factors of Lp(a) and non-high-density lipoprotein cholesterol contribute substantially to the frequent co-occurence of these diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.1038/s41467-018-03252-6

  2 / 39577 MEDLINE  
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[PMID]: 29305337
[Au] Autor:Liberale L; Carbone F; Bertolotto M; Bonaventura A; Vecchié A; Mach F; Burger F; Pende A; Spinella G; Pane B; Palombo D; Dallegri F; Montecucco F
[Ad] Address:First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; Center for Molecular Cardiology, University of Zürich, Wagistrasse 12, 8952 Schlieren, Switzerland. Electronic address: luca.liberale@uzh.ch.
[Ti] Title:Serum adiponectin levels predict acute coronary syndrome (ACS) in patients with severe carotid stenosis.
[So] Source:Vascul Pharmacol;102:37-43, 2018 Mar.
[Is] ISSN:1879-3649
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:As endocrine organ, adipose tissue may modulate inflammatory response by releasing a wide range of mediators, known as adipocytokines. Due to the complex balance between pro- and anti-inflammatory activity their pathophysiological and prognostic role in cardiovascular (CV) diseases still remains debated. Here, we consider the potential associations of circulating adipocytokines adiponectin, leptin and their ratio (LAR), with metabolic and inflammatory profiles in 217 patients with severe carotid stenosis. A prospective analysis investigating their predictive role toward acute coronary syndromes (ACS) was also drawn over a 12-month follow-up period. Serum leptin was positively associated with fasting insulinemia and HOMA-IR, but not with lipid profile and inflammation. Conversely, adiponectin was negatively associated with glucose, insulin, HOMA-IR, triglycerides and both systemic and intraplaque inflammatory markers whereas a positive association with high-density lipoprotein cholesterol (HDL-c) was observed. Accordingly, a significant association with metabolic profile was reported for LAR. According to the cut-off point identified by ROC curve, adiponectin values≤2.56µg/mL were correlated with a higher risk of ACS occurrence at 12months' follow-up (p-value for Log Rank test=0.0003). At Cox regression analysis the predictive ability of low serum adiponectin was confirmed also after adjustment for age, male gender and diabetes. In conclusion, adiponectin may be considered a biomarker of metabolic compensation, inversely associated with chronic low-grade inflammation. Circulating adiponectin is also associated with lower risk of adverse CV events in patients with severe carotid stenosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review

  3 / 39577 MEDLINE  
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[PMID]: 29522104
[Au] Autor:Suwalski G; Emery R; Mróz J; Kaczejko K; Gryszko L; Cwetsch A; Skrobowski A
[Ad] Address:Department of Cardiac Surgery, Military Institute of Medicine, Warsaw, Poland.
[Ti] Title:Freedom from pulmonary vein stenosis after multiple applications of epicardial ablation energy.
[So] Source:Interact Cardiovasc Thorac Surg;, 2018 Mar 07.
[Is] ISSN:1569-9285
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: In patients undergoing cardiac surgical procedures, pulmonary vein isolation may be easily accomplished, and it is important to achieve bidirectional conduction block across created lesions. The primary aim of this study was to assess the risk of pulmonary vein stenosis (PVS) after multiple applications of epicardial bipolar radiofrequency energy. METHODS: Thirty-five consecutive patients who were referred for off-pump coronary revascularization with concomitant pulmonary vein isolation and left atrial appendage occlusion were prospectively included in the study. The ablation protocol provided 8 standard epicardial applications of bipolar energy with additional applications until the acute bidirectional conduction block was achieved. Three to 6 months after surgery, patients underwent computed tomography to assess PVS. RESULTS: In all patients, bidirectional conduction block was achieved across the created lesions. In 31 (89%) patients, conduction block was accomplished after the standard 8 energy applications on each side. In 4 (11%) patients, additional applications of energy were needed. All patients had computed tomography (128 total pulmonary veins) scans, which showed no evidence of PVS. CONCLUSIONS: Multiple applications of bipolar radiofrequency energy during off-pump epicardial pulmonary vein isolation did not lead to PVS. Creating bidirectional conduction block using multiple energy applications through created lesions is feasible in all patients using the ablation protocol described.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1093/icvts/ivy065

  4 / 39577 MEDLINE  
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[PMID]: 29521447
[Au] Autor:Lee JH; Han D; Hartaigh BÓ; Gransar H; Lu Y; Rizvi A; Park MW; Roudsari HM; Stuijfzand WJ; Berman DS; Callister TQ; DeLago A; Hadamitzky M; Hausleiter J; Al-Mallah MH; Budoff MJ; Kaufmann PA; Raff G; Chinnaiyan K; Cademartiri F; Maffei E; Villines TC; Kim YJ; Leipsic J; Feuchtner G; Pontone G; Andreini D; Marques H; Rubinshtein R; Achenbach S; Shaw LJ; Chang HJ; Bax J; Chow B; Cury RC; Gomez M; Jones EC; Lin FY; Min JK; Peña JM
[Ad] Address:Dalio Institute of Cardiovascular Imaging, Department of Radiology, NewYork-Presbyterian Hospital and Weill Cornell Medicine, New York, NY, USA.
[Ti] Title:Influence of Symptom Typicality for Predicting MACE in Patients Without Obstructive Coronary Artery Disease: From the CONFIRM Registry (Coronary Computed Tomography Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry).
[So] Source:Clin Cardiol;, 2018 Mar 09.
[Is] ISSN:1932-8737
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To assess the prognostic value of symptom typicality in patients without obstructive coronary artery disease (CAD), determined by coronary computed tomographic angiography (CCTA). METHODS: 4,215 patients without prior history of CAD and without obstructive CAD (<50% CCTA stenosis) were identified. CAD severity was categorized as non-obstructive (1%-49%) and none (0%). Based upon the Diamond-Forrester criteria for angina pectoris, symptom typicality was classified as: asymptomatic, non-anginal, atypical, and typical. Multivariable Cox proportional hazards models were used to assess the risk of major adverse cardiac events (MACE), comprising all-cause mortality, myocardial infarction, unstable angina and late revascularization, according to symptom typicality. RESULTS: Mean age was 57.0±12.0 years (54.9% male). During a median follow-up of 5.3 years (IQR, 4.6-5.9 years), MACE was reported in 312 (7.4%) patients. Among patients with non-obstructive CAD, there was an association between symptom typicality and MACE (p for interaction =.05), driven by increased risk of MACE among those with typical angina and non-obstructive CAD (HR 1.62, 95% CI: 1.06-2.48, P =.03). No consistent relationship was found between symptom typicality and MACE among patients without any CAD (HR 0.73, 95% CI: 0.34-1.57, P =.08). CONCLUSIONS: In the CONFIRM registry, patients who presented with concomitant typical angina and non-obstructive CAD had a higher rate of MACE than asymptomatic patients with non-obstructive CAD. However, the presence of typical angina did not appear to portend worse prognosis in patients with no CAD.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1002/clc.22940

  5 / 39577 MEDLINE  
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[PMID]: 29520004
[Au] Autor:Tsai SY; Wang SY; Shiau YC; Wu YW
[Ad] Address:Department of Nuclear Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
[Ti] Title:Mechanical dyssynchrony and diastolic dysfunction are common in LVH: a pilot correlation study using Doppler echocardiography and CZT gated-SPECT MPI.
[So] Source:Sci Rep;8(1):4182, 2018 Mar 08.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Hypertrophic cardiomyopathy (HCM) is an often under-diagnosed cause of left ventricular hypertrophy (LVH). It affects 1/500 of the population, is the most commonly inherited cardiovascular disorder, and can present in apical, concentric, or septal forms. Although most patients are asymptomatic, sudden cardiac death can be the initial presentation of HCM. By retrospectively enrolling patients suspected of having three different types of HCM in the absence of epicardial coronary stenosis, we aimed to examine systolic and diastolic dysfunction and perfusion abnormalities using both Doppler echocardiography and state-of-the-art gated single-photon emission computerized tomography (SPECT) myocardial perfusion imaging (MPI) with a cadmium-zinc-telluride camera and thallium-201. Both regional perfusion and gated SPECT parameters were collected in addition to diastolic parameters from Doppler echocardiography. The results showed that mild ischemia was common in patients suspected of having HCM, with a mean summed stress score of 4.7 ± 4.9 (score 0-4 in 17-segment model). The patients with HCM were associated with discernible left ventricular mechanical dyssynchrony, especially those with the apical form. In addition, diastolic dysfunction was prevalent and early to late ventricular filling velocity ratios were significantly different between groups. By combining gated-MPI and Doppler data, the trivial functional changes in HCM may be identified.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-22213-z

  6 / 39577 MEDLINE  
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[PMID]: 29519811
[Au] Autor:McCarthy CP; Ibrahim NE; Lyass A; Li Y; Gaggin HK; Simon ML; Mukai R; Gandhi P; Kelly N; Motiwala SR; van Kimmenade RRJ; Massaro JM; D'Agostino RB; Januzzi JL
[Ad] Address:Department of Medicine, Massachusetts General Hospital, Boston, MA.
[Ti] Title:Single-Molecule Counting of High-Sensitivity Troponin I in Patients Referred for Diagnostic Angiography: Results From the CASABLANCA (Catheter Sampled Blood Archive in Cardiovascular Diseases) Study.
[So] Source:J Am Heart Assoc;7(6), 2018 Mar 08.
[Is] ISSN:2047-9980
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The meaning of high-sensitivity troponin I (hsTnI) concentrations in patients without acute myocardial infarction (MI) requires clarity. We hypothesized that among patients referred for diagnostic coronary angiography without acute MI, hsTnI concentrations would correlate with prevalent coronary artery disease (CAD) and predict incident cardiovascular events and mortality. METHODS AND RESULTS: We measured hsTnI using a single-molecule counting assay (99th percentile, 6 ng/L) in samples from 991 patients obtained at the time of angiography. Concentrations of hsTnI were assessed relative to the severity of CAD and prognosis during mean follow-up of 3.7 years. Median hsTnI concentration was 4.19 ng/L; 38% of patients had hsTnI concentrations ≥99th percentile. Across increasing hsTnI quartiles, patients had higher prevalence of angiographic CAD; in multivariate models, hsTnI ≥99th percentile independently predicted obstructive CAD (odds ratio: 2.57; <0.001) and incident MI (hazard ratio [HR]: 2.68; <0.001), cardiovascular death (HR: 2.29; =0.001), and all-cause death (HR: 1.84; =0.004). In those with >70% coronary stenosis, hsTnI ≥99th percentile independently predicted incident MI (HR: 1.87; =0.01), cardiovascular mortality (HR: 2.74; =0.001), and the composite end point of MI and all-cause death (HR: 2.06; <0.001). In participants with coronary stenosis <70%, hsTnI ≥99th percentile even more strongly predicted incident MI (HR: 8.41; <0.001), cardiovascular mortality (HR: 3.60; =0.03), and the composite end point of MI and all-cause death (HR: 3.62; <0.001). CONCLUSIONS: In a large prospective cohort of patients who were free of prevalent MI and undergoing diagnostic coronary angiography, hsTnI concentrations were associated with higher prevalence of CAD and predicted incident MI, cardiovascular death, and all-cause death. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00842868.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Data-Review

  7 / 39577 MEDLINE  
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[PMID]: 29519729
[Au] Autor:Rodriguez AE; Fernandez-Pereira C; Mieres J; Pavlovsky H; Del Pozo J; Rodriguez-Granillo AM; Antoniucci D
[Ad] Address:Cardiovascular Research Center (CECI), C1024AAA Buenos Aires, Argentina. Electronic address: arodriguez@centroceci.com.ar.
[Ti] Title:Lowering risk score profile during PCI in multiple vessel disease is associated with low adverse events: The ERACI risk score.
[So] Source:Cardiovasc Revasc Med;, 2018 Feb 13.
[Is] ISSN:1878-0938
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In recent years angiographic risk scores have been introduced in clinical practice to stratify different levels of risk after percutaneous coronary interventions (PCI). The SYNTAX score included all intermediate lesions in vessels ≥1.5 mm, consequently, multiple stent implantation was required. Four years ago, we built a new angiographic score in order to guide PCI strategy avoiding stent deployment both in intermediate stenosis as in small vessels, therefore these were not scored (ERACI risk score). The purpose of this mini review is to validate the strategy of PCI guided by this scoring, taking into account long term follow up outcomes of two observational and prospective registries where this policy was used. With this new risk score we have modified risk profile of our patient's candidates for PCI or coronary artery bypass surgery lowering the risk and <20% of them are now included anatomically as high risk for PCI. The simple exclusion of small vessels and intermediate stenosis from the revascularization approach resulted in clinical outcome comparable with the one of fractional flow reserve guided revascularization. Low events rate at late follow up observed in both studies was also in agreement with guided PCI by functional lesion assessment observed by Syntax II registry, where investigators found lower events rate in spite of a few number of stents implanted per patient. IN CONCLUSION: use of ERACI risk scores may significantly reclassify patients into a lower risk category and be associated with low adverse events rate.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  8 / 39577 MEDLINE  
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[PMID]: 29518536
[Au] Autor:Tsunekawa T; Sawada M; Kato T; Motoji Y; Kinoshita T; Hirakawa A; Okawa Y; TomitaMD S
[Ad] Address:Department of Cardiovascular Surgery, Gifu Heart Center, Gifu, Japan. Electronic address: ttsune0707@hotmail.co.jp.
[Ti] Title:The Prevalence and Distribution of Occlusive Lesions of the Cerebral Arteries in Patients Undergoing Coronary Artery Bypass Graft Surgery.
[So] Source:Semin Thorac Cardiovasc Surg;, 2018 Mar 05.
[Is] ISSN:1532-9488
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Intracranial cerebral atherosclerosis is a significant predictor of stroke after coronary artery bypass grafting (CABG). However, there is limited information on intracranial occlusive lesions in patients undergoing CABG. The purpose of the study was to elucidate the precise prevalence and distribution of occlusive lesions of the extracranial and intracranial arteries in patients undergoing CABG. METHODS: Between 2009 and 2016, 205 patients underwent preoperative magnetic resonance angiography (MRA) and elective CABG. The prevalence and the distribution of occlusive lesions were retrospectively examined by preoperative MRA. Association between postoperative central nervous system (CNS) complications and the occlusive lesions was analyzed. RESULTS: Fifty-six patients (27.3%) and 60 patients (29.2%) had occlusive lesions of the extracranial and intracranial arteries, respectively. Twenty-eight patients (13.7%) had both extracranial and intracranial occlusive lesions. Thirty-one (15.1%) and 45 (22.0%) patients had severe stenosis or occlusion of the extracranial and intracranial arteries, respectively. The intracranial internal carotid artery was the most commonly affected intracranial artery (60 vessels; 62.5%), followed by the middle cerebral arteries (20 vessels; 20.8%). Sixteen patients (7.8%) suffered from postoperative CNS complications, including 2 permanent strokes. The etiology of the stroke was attributable to a pre-defined intracranial lesion in one patient. In multivariate analysis, the presence of intracranial occlusive lesions was found to have an independent association with the development of CNS complications (OR, 4.05; 95% CI, 1.13 to 14.6). CONCLUSION: The prevalence of intracranial occlusive lesions was higher than that of extracranial lesions in patients undergoing CABG. There was a solid trend towards the anterior distribution of the intracranial occlusive lesions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher

  9 / 39577 MEDLINE  
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[PMID]: 29361478
[Au] Autor:Shekhar A; Heeger P; Reutelingsperger C; Arbustini E; Narula N; Hofstra L; Bax JJ; Narula J
[Ad] Address:Icahn School of Medicine at Mount Sinai, New York, New York.
[Ti] Title:Targeted Imaging for Cell Death in Cardiovascular Disorders.
[So] Source:JACC Cardiovasc Imaging;11(3):476-493, 2018 Mar.
[Is] ISSN:1876-7591
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cell death is desirable in cancer cells and undesirable in organs with limited regenerative potential, like the heart. Cell death comes in many forms, but only apoptosis and to a lesser degree necrosis is currently relevant to the clinical imager. Noninvasive imaging of cell death is an attractive option to understand pathophysiology, track disease activity, and evaluate response to intervention. Apoptosis seems to be the most promising target for imaging cell death, because it could be reversible and might be modulated with interventions. Molecular, nuclear, optical, or magnetic resonance imaging-based methods have been developed to identify intermediate steps in the apoptosis cascade. Animal studies show promising results for noninvasive imaging in various cardiovascular diseases. Human studies have shown feasibility, but clinical use is yet inconclusive. Newer technologies offer promise, especially for tracking apoptosis in evaluation of novel therapeutic interventions.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

  10 / 39577 MEDLINE  
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[PMID]: 29517516
[Au] Autor:Repossini A; Di Bacco L; Rosati F; Tespili M; Saino A; Ielasi A; Muneretto C
[Ad] Address:Clinical Department of Cardiovascular Surgery, Cardiac Surgery Unit ,University of Brescia.
[Ti] Title:Hybrid coronary revascularization versus percutaneous strategies in left main stenosis: a propensity match study.
[So] Source:J Cardiovasc Med (Hagerstown);, 2018 Mar 06.
[Is] ISSN:1558-2035
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:AIMS: Hybrid revascularization (HCR) has been recently proposed as an alternative strategy in multivessel coronary disease, particularly in patients with high SYNTAX scores and risk scores. The objective of this study is to evaluate the outcomes of HCR versus percutaneous coronary intervention (PCI) drug-eluting stenting in left main treatment. METHODS: A series of 198 consecutive patients with left main stenosis have been treated. HCR, was performed in 77 patients (G1) whereas 121 patients (G2) received PCI on left main. An adjusted analysis using inverse probability weighting (IPW) was performed. Primary outcomes include: 30-day mortality, postoperative acute myocardial infarction, 18 months' MACCEs: cardiac death, stroke, acute myocardial infarction (AMI), repeated target vessel revascularization (TVR). RESULTS: SYNTAX score was 29.5 ±â€Š6.9 in G1 and 29.1 ±â€Š6.5 in G2 (P = 0.529). In G2, three patients (2.7%) died because of cardiogenic shock; no deaths occurred in G1 (P = 0.603). No major complications were reported in G1 and there was no mortality at 18 months' follow-up in both groups. Survival freedom from MACCEs at 18 months' follow-up was significantly higher in G1 (G1: 93.3 ±â€Š4.6% versus G2: 72.3 ±â€Š6.3; P = 0.001) mostly because of the higher freedom from TVR (G1: 93.3 ±â€Š4.6% versus G2: 75.5 ±â€Š5.6; P = 0.002). At Cox regression analysis, PCI was an independent predictor of MACCEs and TVR (hazard ratio 3.9, CI 1.36-9.6; P = 0.027). CONCLUSION: PCI in patients with left main and multivessel disease is a viable strategy, with a good outcome. HCR, demonstrated a lower incidence of cardiac adverse events such as AMI and TVR. Future comparative studies will be helpful to identify the optimal patient population for HCR.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.2459/JCM.0000000000000641


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