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Search on : cranial and nerves [Words]
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[PMID]: 29524722
[Au] Autor:Wang Q; Wu X; Tan M; Wang G; Xu S; Qi Y
[Ad] Address:Department of Spine Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
[Ti] Title:Is anatomical reduction better than partial reduction in patients with vertical atlantoaxial dislocation?
[So] Source:World Neurosurg;, 2018 Mar 07.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To describe lower cranial nerve palsy (LCNP) following vertical over-distraction when performing occipitocervical fusion (OCF) to treat vertical atlantoaxial dislocation (AAD) and basilar invagination (BI) and to investigate its possible causes. METHODS: We report 4 cases with vertical AAD and BI who postoperatively presented with neurogenic dysphagia, dysarthria, and bucking after undergoing anatomical reduction. RESULTS: Patients underwent revision surgery to achieve partial reduction and demonstrated remarkable recovery of 9 , 10 and 11 nerve deficits. CONCLUSION: Performing OCF in the over-distraction position to treat vertical AAD may caudally displace the brainstem relative to the cranial base, resulting in traction injury to the 9th, 10th and 11th nerves where they exit the skull base through the jugular foramen.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 73267 MEDLINE  
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[PMID]: 29237996
[Au] Autor:Uesaka K; Koyama K; Horiuchi N; Kobayashi Y; Nishikawa Y; Inokuma H
[Ad] Address:Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
[Ti] Title:A clinical case of neosporosis in a 4-week-old holstein friesian calf which developed hindlimb paresis postnatally.
[So] Source:J Vet Med Sci;80(2):280-283, 2018 Feb 20.
[Is] ISSN:1347-7439
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:A 4-week-old female Holstein Friesian calf presented with hindlimb paresis. Neurologic examination of spinal reflexes revealed depressed or absent reflexes of the hindlimbs. Menace responses on both sides disappeared on examination of cranial nerves. The calf was finally diagnosed with Neospora caninum infection by pathological findings including nonsuppurative inflammation associated with cysts in the cerebrum and spinal cord. High levels of antibody against recombinant surface antigen 1 of N. caninum (NcSAG1) were detected by ELISA from both serum and cerebrospinal fluid (CSF) samples. This result suggests that detection of antibodies against N. caninum by NcSAG1-ELISA in serum and CSF could be useful for the clinical diagnosis of neosporosis in calves with acquired neurological signs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.1292/jvms.17-0205

  3 / 73267 MEDLINE  
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[PMID]: 29370308
[Au] Autor:Zhang M; Zhou Q; Luo Y; Nguyen T; Rosenblatt MI; Guaiquil VH
[Ad] Address:Department of Ophthalmology and Visual Sciences, University of Illinois-Chicago, Chicago, Illinois, United States of America.
[Ti] Title:Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in development.
[So] Source:PLoS One;13(1):e0191962, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The peripheral sensory nerves that innervate the cornea can be easily damaged by trauma, surgery, infection or diabetes. Several growth factors and axon guidance molecules, such as Semaphorin3A (Sema3A) are upregulated upon cornea injury. Nerves can regenerate after injury but do not recover their original density and patterning. Sema3A is a well known axon guidance and growth cone repellent protein during development, however its role in adult cornea nerve regeneration remains undetermined. Here we investigated the neuro-regenerative potential of Sema3A on adult peripheral nervous system neurons such as those that innervate the cornea. First, we examined the gene expression profile of the Semaphorin class 3 family members and found that all are expressed in the cornea. However, upon cornea injury there is a fast increase in Sema3A expression. We then corroborated that Sema3A totally abolished the growth promoting effect of nerve growth factor (NGF) on embryonic neurons and observed signs of growth cone collapse and axonal retraction after 30 min of Sema3A addition. However, in adult isolated trigeminal ganglia or dorsal root ganglia neurons, Sema3A did not inhibited the NGF-induced neuronal growth. Furthermore, adult neurons treated with Sema3A alone produced similar neuronal growth to cells treated with NGF and the length of the neurites and branching was comparable between both treatments. These effects were replicated in vivo, where thy1-YFP neurofluorescent mice subjected to cornea epithelium debridement and receiving intrastromal pellet implantation containing Sema3A showed increased corneal nerve regeneration than those receiving pellets with vehicle. In adult PNS neurons, Sema3A is a potent inducer of neuronal growth in vitro and cornea nerve regeneration in vivo. Our data indicates a functional switch for the role of Sema3A in PNS neurons where the well-described repulsive role during development changes to a growth promoting effect during adulthood. The high expression of Sema3A in the normal and injured adult corneas could be related to its role as a growth factor.
[Mh] MeSH terms primary: Nerve Regeneration/drug effects
Semaphorin-3A/pharmacology
[Mh] MeSH terms secundary: Animals
Epithelium, Corneal/drug effects
Epithelium, Corneal/injuries
Epithelium, Corneal/metabolism
Ganglia, Spinal/cytology
Ganglia, Spinal/drug effects
Growth Cones/drug effects
Mice
Trigeminal Nerve/cytology
Trigeminal Nerve/drug effects
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Semaphorin-3A)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180126
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191962

  4 / 73267 MEDLINE  
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[PMID]: 29518240
[Au] Autor:Tang K; Zhao Y; Yuan X
[Ad] Address:Department of Neurosurgery The 309th Hospital of Chinese People's Liberation Army Beijing, China.
[Ti] Title:Letter: Visualization of Cranial Nerves Using High-Definition Fiber Tractography.
[So] Source:Neurosurgery;, 2018 Mar 06.
[Is] ISSN:1524-4040
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1093/neuros/nyy025

  5 / 73267 MEDLINE  
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[PMID]: 29400038
[Au] Autor:Podeur P; Okhremchuk I; Morvan JB; Vatin L; Rivière D; de Faria A; Joubert C; Dagain A
[Ti] Title:[Multiple intracranial epidermoid cysts: Case report].
[So] Source:Rev Laryngol Otol Rhinol (Bord);136(4):159-62, 2015.
[Is] ISSN:0035-1334
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:Epidermoid cyst is a benign and rare tumor, that evolves slowly. We describe the case of a 55 years-old woman, who came to our consultation for atypical trigeminal neuralgia of left V1 and V2 nerves. Brain MRI found two tumors: T1W hypointense with no appreciable enhancement after gadolinium injection and T2W and diffusion hyperintense. This last feature was in favour of an epidermoid cyst, but the multiplicity of cerebral lesions was definitely not in favor of such a diagnos­tic. They were located behind the right eye and in the left Meckel's cave (trigeminal cave). The surgical strategy consis­ted in removal the retro orbital tumor witch was the most acces­si­ble of both the diagnostic of epidermoid cyst was retaned thanks to the anatomopathology report. As these lesions had the exact same characteristics, we concluded that they were simi­lar. The second epidermoid cyst was not removed because of surgical risk, its benign nature and low evolutionary potential.
[Mh] MeSH terms primary: Brain Diseases/diagnostic imaging
Cranial Fossa, Posterior/diagnostic imaging
Epidermal Cyst/diagnostic imaging
Orbital Diseases/diagnostic imaging
[Mh] MeSH terms secundary: Brain Diseases/pathology
Cranial Fossa, Posterior/pathology
Epidermal Cyst/pathology
Epidermal Cyst/surgery
Female
Humans
Magnetic Resonance Imaging
Middle Aged
Orbital Diseases/pathology
Orbital Diseases/surgery
Trigeminal Neuralgia/etiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:180206
[St] Status:MEDLINE

  6 / 73267 MEDLINE  
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[PMID]: 29400026
[Au] Autor:El Bakkouri W; Blanc R; Benzakin S; Abdellaoui A; Boyeldieu L; Ayache D
[Ti] Title:[Innovations in interventional radiology applied to the field of otolaryngology: A pictorial essay].
[So] Source:Rev Laryngol Otol Rhinol (Bord);136(3):91-5, 2015.
[Is] ISSN:0035-1334
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:The management of hypervascular ENT tumors is usually complex and requires a multidisciplinary approach because of the risk of serious intra-operative bleeding and of potential injuries to cranial nerves and/or large cervical vessels. Over the last four decades, advances in neuro-interventional radio­logical procedures have produced a range of adjunctive endo­vascular techniques in addition to conventional surgery. A pictorial essay in ENT specialty is presented in this article highlighting the most relevant innovations in interventional radiology.
[Mh] MeSH terms primary: Otolaryngology
Radiology, Interventional
[Mh] MeSH terms secundary: Hemorrhage/therapy
Humans
Ophthalmic Artery
Retinal Neoplasms/drug therapy
Retinoblastoma/drug therapy
Tinnitus/therapy
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:180206
[St] Status:MEDLINE

  7 / 73267 MEDLINE  
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[PMID]: 28463416
[Au] Autor:Kaja S; Payne AJ; Naumchuk Y; Koulen P
[Ad] Address:Departments of Ophthalmology and Molecular Pharmacology & Therapeutics, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois.
[Ti] Title:Quantification of Lactate Dehydrogenase for Cell Viability Testing Using Cell Lines and Primary Cultured Astrocytes.
[So] Source:Curr Protoc Toxicol;72:2.26.1-2.26.10, 2017 May 02.
[Is] ISSN:1934-9262
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Drug discovery heavily relies on cell viability studies to assess the potential toxicity of drug candidates. L-Lactate dehydrogenase (LDH) is a cytoplasmic enzyme that catalyzes the concomitant interconversions of pyruvate to L-lactate and NADH to NAD during glycolysis, and the reverse reactions during the Cori cycle. In response to cellular damage, induced by endogenous cellular mechanisms or as a result of exogenously applied insults, LDH is released from the cytoplasm into the extracellular environment. Its stability in cell culture medium makes it a well-suited correlate for the presence of damage and toxicity in tissues and cells. We herein present protocols for a reproducible and validated LDH assay optimized for several cell types. In contrast to commercially available LDH assays, often associated with proprietary formulations and high cost, our protocols provide ample opportunities for experiment-specific optimization with low variability and cost. © 2017 by John Wiley & Sons, Inc.
[Mh] MeSH terms primary: Astrocytes/enzymology
Cell Survival
L-Lactate Dehydrogenase/analysis
Toxicology/methods
[Mh] MeSH terms secundary: Animals
Cell Culture Techniques
Cell Line
Cell Line, Tumor
Culture Media/chemistry
Cytoplasm/enzymology
Extracellular Space/enzymology
Glycolysis
Humans
Neurons/drug effects
Neuroprotective Agents/pharmacology
Optic Nerve/cytology
Optic Nerve/drug effects
Primary Cell Culture
Rats
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Culture Media); 0 (Neuroprotective Agents); EC 1.1.1.27 (L-Lactate Dehydrogenase)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:170503
[St] Status:MEDLINE
[do] DOI:10.1002/cptx.21

  8 / 73267 MEDLINE  
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[PMID]: 27776979
[Au] Autor:Salman IM; Hildreth CM; Phillips JK
[Ad] Address:Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia. Electronic address: ibraheem_muhammed@yahoo.com.
[Ti] Title:Chronic kidney disease impairs renal nerve and haemodynamic reflex responses to vagal afferent input through a central mechanism.
[So] Source:Auton Neurosci;204:65-73, 2017 05.
[Is] ISSN:1872-7484
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:We investigated age- and sex-related changes in reflex renal sympathetic nerve activity (RSNA) and haemodynamic responses to vagal afferent stimulation in a rodent model of chronic kidney disease (CKD). Using anaesthetised juvenile (7-8weeks) and adult (12-13weeks) Lewis Polycystic Kidney (LPK) and Lewis control rats of either sex (n=63 total), reflex changes in RSNA, heart rate (HR) and mean arterial pressure (MAP) to vagal afferent stimulation (5-s train, 4.0V, 2.0-ms pulses, 1-16Hz) were measured. In all groups, stimulation of the vagal afferents below 16Hz produced frequency-dependent reductions in RSNA, HR and MAP, while a 16Hz stimulus produced an initial sympathoinhibition followed by sympathoexcitation. In juvenile LPK versus age-matched Lewis, sympathoinhibition was reduced when responses were expressed as % baseline (P<0.05), but not as microvolts, while bradycardic responses were greater. Reflex depressor responses were greater (P=0.015) only in juvenile female LPK. In adult LPK, reflex sympathoinhibition (%) was blunted (P<0.05), and an age-related decline apparent (when expressed as microvolts). Reflex reductions in HR and MAP were only diminished (P<0.05) in adult female LPK versus age-matched Lewis. Peak reflex sympathoexcitation at 16Hz did not differ between groups; however, area under the curve values were greater in the LPK versus Lewis (overall, 9±1 versus 19±3µVs, P<0.05) irrespective of age, suggestive of enhanced sympathoexcitatory drive in the LPK. Our data demonstrates a progressive deficit in the central processing of vagal afferent input and a differential sex influence on reflex regulation of autonomic function and blood pressure homeostasis in CKD.
[Mh] MeSH terms primary: Hemodynamics/physiology
Kidney/innervation
Kidney/physiopathology
Reflex/physiology
Renal Insufficiency, Chronic/physiopathology
Vagus Nerve/physiopathology
[Mh] MeSH terms secundary: Afferent Pathways/physiopathology
Animals
Area Under Curve
Blood Pressure/physiology
Cohort Studies
Disease Models, Animal
Female
Heart Rate/physiology
Male
Rats, Inbred Lew
Species Specificity
Sympathetic Nervous System/physiopathology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1708
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:161026
[St] Status:MEDLINE

  9 / 73267 MEDLINE  
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[PMID]: 29516437
[Au] Autor:Wei DY; Jensen RH
[Ad] Address:Headache Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Diana.wei@kcl.ac.uk.
[Ti] Title:Therapeutic Approaches for the Management of Trigeminal Autonomic Cephalalgias.
[So] Source:Neurotherapeutics;, 2018 Mar 07.
[Is] ISSN:1878-7479
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Trigeminal autonomic cephalalgia (TAC) encompasses 4 unique primary headache types: cluster headache, paroxysmal hemicrania, hemicrania continua, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms. They are grouped on the basis of their shared clinical features of unilateral headache of varying durations and ipsilateral cranial autonomic symptoms. The shared clinical features reflect the underlying activation of the trigeminal-autonomic reflex. The treatment for TACs has been limited and not specific to the underlying pathogenesis. There is a proportion of patients who are refractory or intolerant to the current standard medical treatment. From instrumental bench work research and neuroimaging studies, there are new therapeutic targets identified in TACs. Treatment has become more targeted and aimed towards the pathogenesis of the conditions. The therapeutic targets range from the macroscopic and structural level down to the molecular and receptor level. The structural targets for surgical and noninvasive neuromodulation include central neuromodulation targets: posterior hypothalamus and, high cervical nerves, and peripheral neuromodulation targets: occipital nerves, sphenopalatine ganglion, and vagus nerve. In this review, we will also discuss the neuropeptide and molecular targets, in particular, calcitonin gene-related peptide, somatostatin, transient receptor potential vanilloid-1 receptor, nitric oxide, melatonin, orexin, pituitary adenylate cyclase-activating polypeptide, and glutamate.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1007/s13311-018-0618-3

  10 / 73267 MEDLINE  
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[PMID]: 29429179
[Au] Autor:Zhao SY; Ma YH; Yin Z; Zhan XX; Cheng RC; Qian J
[Ad] Address:Department of Thyroid Surgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
[Ti] Title:[Evaluation of central lymph node dissection for papillary thyroid carcinoma in cN0 T1/T2].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(2):105-109, 2018 Feb 07.
[Is] ISSN:1673-0860
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To evaluate the application of the central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) in cN0 T1/T2. Retrospective analysis of 532 cases with PTC in cN0 T1/T2 who underwent CLND between October 2014 and September 2016 in the Department of Thyroid Surgery, the First Affiliated Hospital of the Kunming Medical University. The incidence of central lymph node (CLN) metastasis and risk factors were analyzed. CLN metastasis rates: 41.2% (42/102) in males vs 34.9% (150/430) in females, =0.252; 33.9% (116/342) in single focal carcinoma vs 40.4% (74/183) in multifocal carcinoma, =0.157; 44.0% (125/284) in patients with 45 years old or less vs 27.0% (67/248) in patients more than 45 years old, =0.000; 30.3% (113/373) in microcarcinoma vs 50.9% (81/159) in non-microcarcinoma, =0.000.In unilateral lesions, ipsilateral CLN metastasis was correlated with the tumor diameter ( =0.012), but not with the number of lesions ( =0.653). also contralateral CLN metastasis was correlated with the tumor diameter ( =0.000), but not with the number of lesions ( =0.815). For the left or right unilateral single focal lesion, the tumor diameter was not correlated with the metastasis of the posterior to right recurrent laryngeal nerve central lymph nodes (LN-prRLN-CLN) ( =0.652, =0.088). But in bilateral multifocal carcinoma the tumor diameter was correlated with metastasis of LN-prRLN-CLN ( =0.039). Prophylactic CLND is reasonable for PTC in cN0 T1/T2. A bilateral CLND should be conducted for patients with bilateral multi-focus cancer and unilateral or bilateral non-microcarcinoma, especially in patients more than 45 years old. For unilateral single focal microcarcinoma on the right, the content of CLND should be from laryngeal nerve on right center to posterior branche; for unilateral single focal microcarcinoma on the left side, the left CLND should be conducted. An ipsilateral CLND can be considered in patients with unilateral multifocal microcarcinoma, and generally a routine dissection of the LN-prRLN-CLN is not required, however for bilateral non-microcarcinoma and the the non-microcarcinoma on the right side, the LN-prRLN-CLN dissection should be conducted.
[Mh] MeSH terms primary: Carcinoma, Papillary/surgery
Lymph Node Excision/methods
Lymph Nodes/surgery
Thyroid Neoplasms/surgery
[Mh] MeSH terms secundary: Adult
Carcinoma, Papillary/secondary
Cranial Nerve Neoplasms/secondary
Female
Humans
Laryngeal Nerves
Lymph Nodes/pathology
Lymphatic Metastasis
Male
Middle Aged
Recurrent Laryngeal Nerve
Retrospective Studies
Risk Factors
Thyroid Neoplasms/pathology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.02.005


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