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[PMID]: 29325918
[Au] Autor:Nan X; Su S; Ma K; Ma X; Wang X; Zhaxi D; Ge R; Li Z; Lu D
[Ad] Address:Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China.
[Ti] Title:Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats.
[So] Source:J Ethnopharmacol;216:175-183, 2018 Apr 24.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Rhodiola algida var. tangutica (Maxim.) S.H. Fu is a perennial plant of the Crassulaceae family that grows in the mountainous regions of Asia. The rhizome and roots of this plant have been long used as Tibetan folk medicine for preventing high latitude sickness. AIM OF THE STUDY: The aim of this study was to determine the effect of bioactive fraction from R. algida (ACRT) on chronic hypoxia-induced pulmonary arterial hypertension (HPAH) and to understand the possible mechanism of its pharmacodynamic actions. MATERIALS AND METHODS: Male Sprague-Dawley rats were separated into five groups: control group, hypoxia group, and hypoxia+ACRT groups (62.5, 125, and 250mg/kg/day of ACRT). The chronic hypoxic environment was created in a hypobaric chamber by adjusting the inner pressure and oxygen content for 4 weeks. After 4 weeks, major physiological parameters of pulmonary arterial hypertension such as mPAP, right ventricle index (RV/LV+S, RVHI), hematocrit (Hct) levels and the medial vessel thickness (wt%) were measured. Protein and mRNA expression levels of proliferating cell nuclear antigen (PCNA), cyclin D1, p27Kip1 and cyclin-dependent kinase 4 (CDK4)) were detected by western blotting and real time PCR respectively. Chemical profile of ACRT was revealed by ultra performance liquid chromatography coupled with quadrupole time of flight mass spectrometry (UHPLC-Q-TOF-MS/MS). RESULTS: The results showed that a successful HPAH rat model was established in a hypobaric chamber for 4 weeks, as indicated by the significant increase in mPAP, RV/LV+S, RV/BW and wt%. Compared with the normal group, administration of ACRT reduced mPAP, right ventricular hypertrophy, pulmonary small artery wall thickness, and damage in ultrastructure induced by hypoxia in rats. PCNA, cyclin D1, and CDK4 expression was reduced (p<0.05), and p27Kip1 expression increased (p<0.05) in hypoxia+ACRT groups compared to hypoxia. 38 constituents in bioactive fraction were identified by UHPLC-Q-TOF-MS/MS. CONCLUSION: Our results suggest that ACRT could alleviate chronic hypoxia-induced pulmonary arterial hypertension. And its anti-proliferation mechanism in rats based on decreasing PCNA, cyclin D1, CDK4 expression level and inhibiting p27Kip1 degradation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process

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[PMID]: 28610437
[Au] Autor:Song Y; Zhou J; Wang X; Xie X; Zhao Y; Ni F; Huang W; Wang Z; Xiao W
[Ad] Address:a Jiangsu Kanion Pharmaceutical Co., Ltd. , Lianyungang , People's Republic of China.
[Ti] Title:A new ferulic acid ester from Rhodiola wallichiana var. cholaensis (Crassulaceae).
[So] Source:Nat Prod Res;32(1):77-84, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A new ferulic acid ester, 6-feruloyloxyhexanoic acid (1), was isolated along with 10 known ones (2-11), from the concentrated water extract of Rhodiola wallichiana var. cholaensis. Their chemical structures were elucidated on the basis of extensive spectroscopic methods including Two-dimensional nuclear magnetic resonance (2D NMR) experiments. Compound 3 was isolated from this plant for the first time. The protective effects against H O -induced myocardial cell injury in cultured H9c2 cells were also evaluated. Compounds 1, 5 and 7-11 provided significant protective effects on H O -induced H9c2 cells injury at the concentration of 25 µg/mL. And the protective effects of compound 1 was also investigated by the oxygen-glucose deprivation/reperfusion (OGD/R) tests.
[Mh] MeSH terms primary: Caproates/pharmacology
Cardiotonic Agents/pharmacology
Coumaric Acids/pharmacology
Rhodiola/chemistry
[Mh] MeSH terms secundary: Animals
Antioxidants/chemistry
Antioxidants/pharmacology
Caproates/administration & dosage
Caproates/chemistry
Cardiotonic Agents/administration & dosage
Cardiotonic Agents/chemistry
Cells, Cultured
Coumaric Acids/administration & dosage
Coumaric Acids/chemistry
Dose-Response Relationship, Drug
Esters/administration & dosage
Esters/chemistry
Esters/pharmacology
Hydrogen Peroxide/toxicity
Magnetic Resonance Spectroscopy
Molecular Structure
Myocytes, Cardiac/cytology
Myocytes, Cardiac/drug effects
Plant Extracts/chemistry
Rats
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antioxidants); 0 (Caproates); 0 (Cardiotonic Agents); 0 (Coumaric Acids); 0 (Esters); 0 (Plant Extracts); BBX060AN9V (Hydrogen Peroxide)
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:170615
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1335724

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[PMID]: 29441910
[Au] Autor:Woith E; Stintzing F; Melzig MF
[Ti] Title:SOD activity and extremophilicity: a screening of various plant species.
[So] Source:Pharmazie;72(8):490-496, 2017 Aug 01.
[Is] ISSN:0031-7144
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:All aerobes are dependent on enzymatic and non-enzymatic antioxidants to withstand the presence of reactive oxygen species (ROS). Superoxide dismutase (SOD) is a part of the enzymatic antioxidant system. It is one of the most important antioxidant enzymes, enabling organisms to survive in an oxygen containing atmosphere. A disorder in the oxidative and antioxidative balance can be associated with the occurrence of diseases in human organisms. Little data exist on the relevance of SOD in plants. Moreover, it is not known whether there is any association between a plant's origin and its SOD activity. Our screening of 27 different plant species was intended to expose whether there is a connection. The highest SOD activities were found for extremophile plants. Especially the Crassulaceae Aeonium haworthii Salm-Dyck Ex Webb & Berthel. and Crassula multiflora Schönland & Baker F. were highly active. Nevertheless, we did not find unambiguous evidence for a correlation between extremophilicity and SOD activity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Process
[do] DOI:10.1691/ph.2017.7493

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[PMID]: 29309848
[Au] Autor:Li YC; Zhong DL; Rao GY; Wen J; Ren Y; Zhang JQ
[Ad] Address:College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China.
[Ti] Title:Gone with the trees: Phylogeography of Rhodiola sect. Trifida (Crassulaceae) reveals multiple refugia on the Qinghai-Tibetan Plateau.
[So] Source:Mol Phylogenet Evol;121:110-120, 2018 Apr.
[Is] ISSN:1095-9513
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Quaternary climatic oscillations have had tremendous effects on current distribution of species. Previous studies unraveled multiple microrefugia on the Qinghai-Tibetan Plateau (QTP) in two woody plants. Still we know little whether herbs growing in forests responded to climatic oscillations similarly. We herein conducted a phylogeographic study on Rhodiola sect. Trifida, an herbaceous group endemic to the QTP, which mainly growing on the forest floors, using plastid and ITS sequences as well as ecological niche modeling. The origin and divergence of major clades of sect. Trifida were in accordance with the last phase of the QTP uplifts. Mismatch distribution analysis indicated a range expansion dated to ca. 135 thousand years ago. A high frequency and an even distribution of private haplotypes in both plastid and ITS data sets throughout the distribution of sect. Trifida were detected. The ecological niche modeling results showed that there were suitable habitats on the QTP platform during the LGM. Our results found that multiple microrefugia existed on the QTP platform, supporting the hypothesis that species with similar geographic distribution and inhabiting the same community had similar responses to the Quaternary climatic oscillations. Furthermore, species delimitations in sect. Trifida need to be tested based on integrative evidence from morphological, ecological and genetic data.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Data-Review

  5 / 308 MEDLINE  
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[PMID]: 29349835
[Au] Autor:Dos Santos Nascimento LB; de Aguiar PF; Leal-Costa MV; Coutinho MAS; Borsodi MPG; Rossi-Bergmann B; Tavares ES; Costa SS
[Ad] Address:Department of Botany, Institute of Biology (IB), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
[Ti] Title:Optimization of Aqueous Extraction from Kalanchoe pinnata Leaves to Obtain the Highest Content of an Anti-inflammatory Flavonoid Using a Response Surface Model.
[So] Source:Phytochem Anal;, 2018 Jan 19.
[Is] ISSN:1099-1565
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: The medicinal plant Kalanchoe pinnata is a phenolic-rich species used worldwide. The reports on its pharmacological uses have increased by 70% in the last 10 years. The leaves of this plant are the main source of an unusual quercetin-diglycosyl flavonoid (QAR, quercetin arabinopyranosyl rhamnopyranoside), which can be easily extracted using water. QAR possess a strong in vivo anti-inflammatory activity. OBJECTIVE: To optimize the aqueous extraction of QAR from K. pinnata leaves using a three-level full factorial design. MATERIAL AND METHODS: After a previous screening design, time (x ) and temperature (x ) were chosen as the two independent variables for optimization. Freeze-dried leaves were extracted with water (20% w/v), at 30°C, 40°C or 50°C for 5, 18 or 30 min. QAR content (determined by HPLC-DAD) and yield of extracts were analyzed. The optimized extracts were also evaluated for cytotoxicity. RESULTS: The optimal heating times for extract yield and QAR content were similar in two-dimensional (2D) surface responses (between 12.8 and 30 min), but their optimal extraction temperatures were ranged between 40°C and 50°C for QAR content and 30°C and 38°C for extract yield. A compromise region for both parameters was at the mean points that were 40°C for the extraction temperature and 18 min for the total time. CONCLUSION: The optimized process is faster and spends less energy than the previous one (water; 30 min at 55°C); therefore is greener and more attractive for industrial purposes. This is the first report of extraction optimization of this bioactive flavonoid. Copyright © 2018 John Wiley & Sons, Ltd.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180119
[Lr] Last revision date:180119
[St] Status:Publisher
[do] DOI:10.1002/pca.2744

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[PMID]: 29199225
[Au] Autor:Warashina T; Miyase T
[Ad] Address:School of Food and Nutritional Sciences, University of Shizuoka.
[Ti] Title:Flavonoid Glycosides from Sedum bulbiferum.
[So] Source:Chem Pharm Bull (Tokyo);65(12):1199-1204, 2017.
[Is] ISSN:1347-5223
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:The MeOH extract from dried whole Sedum bulbiferum MAKINO (Crassulaceae) plants yielded 34 compounds, including six new flavonoid glycosides and 28 known compounds. The structures of new compounds were established using NMR, Mass spectroscopic analysis and chemical evidence.
[Mh] MeSH terms primary: Glycosides/chemistry
Sedum/chemistry
[Mh] MeSH terms secundary: Flavonoids/chemistry
Flavonoids/isolation & purification
Glycosides/isolation & purification
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Conformation
Plant Extracts/chemistry
Sedum/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Flavonoids); 0 (Glycosides); 0 (Plant Extracts)
[Em] Entry month:1801
[Cu] Class update date: 180110
[Lr] Last revision date:180110
[Js] Journal subset:IM
[Da] Date of entry for processing:171205
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00678

  7 / 308 MEDLINE  
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[PMID]: 28840347
[Au] Autor:Brzezicka E; Kozieradzka-Kiszkurno M
[Ad] Address:Department of Plant Cytology and Embryology, Faculty of Biology, University of Gdansk, 59 Wita Stwosza Street, 80-308, Gdansk, Poland.
[Ti] Title:Ultrastructural and cytochemical aspects of female gametophyte development in Sedum hispanicum L. (Crassulaceae).
[So] Source:Protoplasma;, 2017 Aug 24.
[Is] ISSN:1615-6102
[Cp] Country of publication:Austria
[La] Language:eng
[Ab] Abstract:Until now, development of the female gametophyte has been investigated only in some species of Crassulaceae using a light microscope. To the best of our knowledge, this is the first report that describes the process of megasporogenesis and megagametogenesis in Crassulaceae in detail. To achieve this, we performed embryological studies on Sedum hispanicum L. (Crassulaceae). Cytochemical analysis detected the presence of proteins, lipids, and insoluble polysaccharides in individual cells of the gametophyte. The development of the embryo sac conforms to the monosporic or Polygonum-type in anatropous, crassinucellate, and bitegmic ovules. One megaspore mother cell initiates the process of megasporogenesis. Prior to the first meiotic division, the nucleus is centrally located within the meiocyte. Other organelles seem to be distributed evenly over the micropylar and chalazal parts during the development. Most storage reserves detected during megasporogenesis were observed in the megaspore mother cell. Three mitotic divisions within the chalazal functional megaspore resulted in the enlargement of the eight-nucleated embryo sac. In the seven-celled gametophyte, three chalazally located antipodes degenerated. A mature embryo sac was formed by the egg apparatus and central cell. When the antipodes degenerated, both synergids became organelle-rich and more active. The concentration of lipid droplets, starch grains, and proteins increased during megagametogenesis in the growing gametophyte. In the cellular embryo sac, the central cell can be distinguished by its largest accumulation. Our data confirm the hypothesis that plasmodesmata with electron-dense dome are formed during development of the female gametophyte in S. hispanicum and not just during the stages of embryogenesis. We observed these structures in megaspores and coenocytic embryo sac walls. Functions of observed plasmodesmata are discussed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170825
[Lr] Last revision date:170825
[St] Status:Publisher
[do] DOI:10.1007/s00709-017-1155-3

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[PMID]: 28704842
[Au] Autor:Das G; Patra JK; Lee SY; Kim C; Park JG; Baek KH
[Ad] Address:Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Gyeonggi-do, Republic of Korea.
[Ti] Title:Analysis of metabolomic profile of fermented Orostachys japonicus A. Berger by capillary electrophoresis time of flight mass spectrometry.
[So] Source:PLoS One;12(7):e0181280, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Microbial cell performance in food biotechnological processes has become an important concern for improving human health worldwide. Lactobacillus plantarum, which is widely distributed in nature, is a lactic acid bacterium with many industrial applications for fermented foods or functional foods (e.g., probiotics). In the present study, using capillary electrophoresis time of flight mass spectrometry, the metabolomic profile of dried Orostachys japonicus A. Berger, a perennial medicinal herb with L. plantarum was compared with that of O. japonicus fermented with L. plantarum to elucidate the metabolomic changes induced by the fermentation process. The levels of several metabolites were changed by the fermentation process, indicating their involvement in microbial performance. For example, glycolysis, the pentose phosphate pathway, the TCA cycle, the urea cycle-related metabolism, nucleotide metabolism, and lipid and amino acid metabolism were altered significantly by the fermentation process. Although the fermented metabolites were not tested using in vivo studies to increase human health benefits, our findings provide an insight into the alteration of metabolites induced by fermentation, and indicated that the metabolomic analysis for the process should be accompanied by fermenting strains and conditions.
[Mh] MeSH terms primary: Crassulaceae/chemistry
Food Microbiology/methods
Mass Spectrometry/methods
Metabolome
Plants, Medicinal/chemistry
[Mh] MeSH terms secundary: Crassulaceae/metabolism
Crassulaceae/microbiology
Electrophoresis, Capillary
Fermentation
Humans
Lactic Acid/metabolism
Lactobacillus plantarum/physiology
Metabolomics/methods
Plants, Medicinal/metabolism
Plants, Medicinal/microbiology
Probiotics/chemistry
Probiotics/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:33X04XA5AT (Lactic Acid)
[Em] Entry month:1709
[Cu] Class update date: 170929
[Lr] Last revision date:170929
[Js] Journal subset:IM
[Da] Date of entry for processing:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181280

  9 / 308 MEDLINE  
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[PMID]: 28680326
[Au] Autor:Lewicki S; Orlowski P; Krzyzowska M; Kiepura A; Skopinska-Rózewska E; Zdanowski R
[Ad] Address:Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology, Poland.
[Ti] Title:The effect of feeding mice during gestation and nursing with extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny.
[So] Source:Cent Eur J Immunol;42(1):10-16, 2017.
[Is] ISSN:1426-3912
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Rhodiola kirilowii, a member of Crassulaceae family, grows wildly in Asiatic mountains and is also cultivated in some European countries. Its underground parts traditionally are used for enhance physical and mental performance of the body. In our previous papers we reported immuno- and angio-modulatory effects of aqueous and hydro-alcoholic extracts of radix and rhizome of this plant in mice. In the present work we evaluated the effect of Rhodiola kirilowii water- (RKW) or hydro-alcoholic (RKW-A) extracts and epigallocatechin (one of the polyphenols present in these extracts) given to mice, during pregnancy and nursing period, on the number and localization of CD4+ and CD8+ cells in spleens of adult progeny mice. Previously, we observed several abnormalities in functionality of spleen cells collected from these mice. No differences in CD4+ T cells localisation or numbers were found between all tested mice groups. In contrast, CD8+ T cells localisation and staining were altered in progeny of water or alcohol extract-fed mice. CD8+ T cells were found not only in the PALS but also in the B cell follicle and in the red pulp. Furthermore, CD8+ T cells from T cell zones in the progeny of extract-fed mice showed much intensive staining for CD8 antigen and significantly higher numbers per area in comparison to control mice.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170709
[Lr] Last revision date:170709
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5114/ceji.2017.67313

  10 / 308 MEDLINE  
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[PMID]: 28659953
[Au] Autor:Li Z; Han X; Song X; Zhang Y; Jiang J; Han Q; Liu M; Qiao G; Zhuo R
[Ad] Address:State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of ForestryBeijing, China.
[Ti] Title:Overexpressing the Cu/Zn Superoxide Dismutase Increased Resistance to Oxidative Stress in Transgenic .
[So] Source:Front Plant Sci;8:1010, 2017.
[Is] ISSN:1664-462X
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Superoxide dismutase (SOD) is a very important reactive oxygen species (ROS)-scavenging enzyme. In this study, the functions of a gene ( ), from , a cadmium (Cd)/zinc/lead co-hyperaccumulator of the Crassulaceae, was characterized. The expression of was induced by Cd stress. Compared with wild-type (WT) plants, overexpression of gene in transgenic plants enhanced the antioxidative defense capacity, including SOD and peroxidase activities. Additionally, it reduced the damage associated with the overproduction of hydrogen peroxide (H O ) and superoxide radicals (O ). The influence of Cd stress on ion flux across the root surface showed that overexpressing in transgenic plants has greater Cd uptake capacity existed in roots. A co-expression network based on microarray data showed possible oxidative regulation in after Cd-induced oxidative stress, suggesting that S may participate in this network and enhance ROS-scavenging capability under Cd stress. Taken together, these results suggest that overexpressing increased oxidative stress resistance in transgenic and provide useful information for understanding the role of in response to abiotic stress.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3389/fpls.2017.01010


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