Database : MEDLINE Search on : cytomegalovirus [Words] References found : 38450 [refine] Displaying: 1 .. 10   in format [Detailed]

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[PMID]: 23671728 [Au] Autor: Bouguila J; Mabrouk S; Tilouche S; Bakir D; Trabelsi A; Hmila A; Boughammoura L [Ad] Address: Jihene Bouguila, Samia Tilouche, Amel Hmila, Lamia Boughammoura, Department of Paediatrics, Hospital Farhat Hached, 4000 Sousse, Tunisia. [Ti] Title: Giant cell hepatitis with autoimmune hemolytic anemia in a nine month old infant. [So] Source: World J Hepatol;5(4):226-9, 2013 Apr 27. [Is] ISSN: 1948-5182 [Cp] Country of publication: China [La] Language: eng [Ab] Abstract: Giant cell hepatitis (GCH) with autoimmune hemolytic anemia is a rare entity, limited to young children, with an unknown pathogenesis. We report the case of 9-mo old who presented with fever, diarrhea and jaundice four days before hospitalization. Physical examination found pallor, jaundice and hepatosplenomegaly. The laboratory workup showed serum total bilirubin at 101 µmol/L, conjugated bilirubin at 84 µmol/L, hemolytic anemia, thrombocytopenia and immunoglobulin G (IgG) and anti-C3d positive direct Coombs' test. The antinuclear, anti-smooth muscle and liver kidney microsomes 1 non-organ specific autoantibodies, antiendomisium antibodies were negative. Serological assays for viral hepatitis B and C, cytomegalovirus, herpes simplex and Epstein Barr virus were negative. The association of acute liver failure, Evan's syndrome, positive direct Coomb's test of mixed type (IgG and C3) and the absence of organ and non-organ specific autoantibodies suggested the diagnosis of GCH. The diagnosis was confirmed by a needle liver biopsy. The patient was treated by corticosteroids, immunomodulatory therapy and azathioprine but died with septicemia. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [St] Status: In-Data-Review [do] DOI: 10.4254/wjh.v5.i4.226

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[PMID]: 23668613 [Au] Autor: Daikoku T; Saito K; Aihara T; Ikeda M; Takahashi Y; Hosoi H; Nishida T; Takemoto M; Shiraki K [Ad] Address: Department of Virology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. [Ti] Title: Rapid detection of human cytomegalovirus UL97 and UL54 mutations for antiviral resistance in clinical specimens. [So] Source: Microbiol Immunol;57(5):396-9, 2013 May. [Is] ISSN: 1348-0421 [Cp] Country of publication: Australia [La] Language: eng [Ab] Abstract: Drug-resistant cytomegalovirus appears during prolonged anti-cytomegalovirus therapy. Assays for human cytomegalovirus viral protein kinase (UL97) and viral DNA polymerase (UL54) gene mutations conferring drug resistance have been used rather than susceptibility assays to assess clinical specimens. In this study a sensitive system for genotype assay of UL97 and UL54 in clinical specimens with as few as six copies/µg of DNA was developed. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1111/1348-0421.12043

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[PMID]: 23671435 [Au] Autor: Puz P; Lasek-Bal A; Ziaja D; Kazibutowska Z; Ziaja K [Ad] Address: Stroke Department, Medical Centre of Silesia, Katowice, Poland. [Ti] Title: Inflammatory markers in patients with internal carotid artery stenosis. [So] Source: Arch Med Sci;9(2):254-60, 2013 Apr 20. [Is] ISSN: 1734-1922 [Cp] Country of publication: Poland [La] Language: eng [Ab] Abstract: INTRODUCTION: Available reports underline the significance of the inflammatory process in the development, progression and destabilisation of atherosclerotic plaques in the internal carotid artery (ICA). The aim of this study was to evaluate the relationship between the degree of ICA stenosis, ultrasound plaque morphology and serum concentration of selected inflammatory markers. MATERIAL AND METHODS: Sixty-five patients with ICA stenosis > 50% (39 symptomatic) and 30 healthy volunteers were enrolled in the study. Clinical, neurological examination and laboratory evaluation (leucocyte count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fibrinogen, tumour necrosis factor-α (TNF-α), interleukins (1ß, 6 and 10), anti-cytomegalovirus IgG antibody titre) were performed. Stenosis grade ≥ 70%, ulcerations on the plaque surface and a hypoechoic (or predominantly hypoechoic) structure of the plaque, obtained by colour-coded duplex examination, were accepted as the characteristics of unstable stenoses. RESULTS: Unstable ultrasound features of ICA stenosis were found significantly more often in symptomatic than in asymptomatic patients (71.79% vs. 30.71% for stenosis degree ≥ 70%, p = 0.001 and 61.23% vs. 38.46% for unstable plaque morphology, p = 0.01). Patients with ICA stenosis had significantly higher serum concentrations of interleukin-6, fibrinogen, ESR and higher CRP values than the individuals from the control group (p = 0.001, p = 0.009, p = 0.036, p = 0.009 respectively). Patients with unstable plaques structure had significantly higher concentrations of TNF-α, interleukin-6, fibrinogen, higher number of leukocytes, monocytes and higher CRP values than patients with stable plaques (p = 0.008, p = 0.049, p = 0.012, p = 0.0002, p = 0.006, p = 0.0003 respectively). No significant differences in above-mentioned parameters between the groups with stenosis < 70% and ≥ 70% were found. CONCLUSIONS: There is a relationship between the activity of the selected inflammatory markers in serum and atherosclerotic unstable internal carotid artery stenosis. There is no relationship between serum concentration of inflammatory markers and degree of carotid artery stenosis. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [St] Status: In-Data-Review [do] DOI: 10.5114/aoms.2013.34533

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[PMID]: 23470252 [Au] Autor: de Jong EP; Vossen AC; Walther FJ; Lopriore E [Ad] Address: Correspondence to Dr Enrico Lopriore, Division of Neonatology, Department of Paediatrics, J6-S, Leiden University Medical Centre, PO Box 9600, Leiden 2300 RC, The Netherlands; e.lopriore@lumc.nl. [Ti] Title: How to use... neonatal TORCH testing. [So] Source: Arch Dis Child Educ Pract Ed;98(3):93-8, 2013 Jun. [Is] ISSN: 1743-0593 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Toxoplasma gondii, rubella, cytomegalovirus and herpes simplex virus have in common that they can cause congenital (TORCH) infection, leading to fetal and neonatal morbidity and mortality. During the last decades, TORCH screening, which is generally considered to be single serum testing, has been increasingly used inappropriately and questions have been raised concerning the indications and cost-effectiveness of TORCH testing. The problems of TORCH screening lie in requesting the screening for the wrong indications, wrong interpretation of the single serum results and in case there is a good indication for diagnosis of congenital infection, sending in the wrong materials. This review provides an overview of the pathogenesis, epidemiology and clinical consequences of congenital TORCH infections and discusses the indications for, and interpretation of, TORCH screens. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1136/archdischild-2012-303327

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[PMID]: 23442093 [Au] Autor: Savva GM; Pachnio A; Kaul B; Morgan K; Huppert FA; Brayne C; Moss PA [Ad] Address: Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Robinson Way, Cambridge, CB20SR, UK. [Ti] Title: Cytomegalovirus infection is associated with increased mortality in the older population. [So] Source: Aging Cell;12(3):381-7, 2013 Jun. [Is] ISSN: 1474-9726 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Cytomegalovirus (CMV) is a common herpesvirus infection and stimulates the expansion of very large numbers of CMV-specific T cells that reduce the CD4/CD8 ratio and suppress the number of naïve T cells. CMV infection has been associated with frailty and impaired survival. We investigated the correlates of CMV and the impact of the CMV infection on mortality within a cohort of 511 individuals aged at least 65 years who were followed up for 18 years. The mean age of the participants was 74 years of which 70% were CMV-seropositive. CMV was strongly linked to socio-economic status, and CMV infection increased the annual mortality rate by 42% (Hazard ratio = 1.42, 95% CI: 1.11-1.76 after adjusting for age, sex and baseline socio-economic and health variables) corresponding to 3.7 years lower life expectancy from age 65. Infection was associated with a near doubling of cardiovascular deaths, whereas there was no increase in mortality from other causes. These results show that CMV infection markedly increases the mortality rate in healthy older individuals due to an excess of vascular deaths. These findings may have significant implications for the study of immune senescence and if confirmed more generally could have important implications for measures to optimize the health of the elderly. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1111/acel.12059

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[PMID]: 23667724 [Au] Autor: El-Cheikh J; Devillier R; Crocchiolo R; Fürst S; Calmels B; Faucher C; Stoppa AM; Granata A; Castagna L; Ladaique P; Lemarie C; Bouabdallah R; Zandotti C; Merlin M; Berger P; Chabannon C; Blaise D [Ad] Address: Unité de Transplantation et de Thérapie Cellulaire (U2T), Institut Paoli-Calmettes, Marseille, France. ; Département d'Onco-Hématologie, Institut Paoli-Calmettes, Marseille, France. [Ti] Title: Impact of pretransplant donor and recipient cytomegalovirus serostatus on outcome for multiple myeloma patients undergoing reduced intensity conditioning allogeneic stem cell transplantation. [So] Source: Mediterr J Hematol Infect Dis;5(1):e2013026, 2013. [Is] ISSN: 2035-3006 [Cp] Country of publication: Italy [La] Language: eng [Ab] Abstract: Scope of the study was to investigate the impact of pre-transplant CMV serostatus of the donor and/or recipient on the outcome of patients undergoing allogeneic hematopoietic stem cell transplantation (Allo-SCT) for Multiple Myeloma (MM). To our knowledge no data are available in the literature about this issue. We retrospectively followed 99 consecutive patients who underwent reduced-intensity conditioning (RIC) Allo-SCT for MM in our cancer center at Marseille between January 2000 and January 2012. Based upon CMV serostatus, patients were classified as low risk (donor [D]-/recipient [R] -) 17 patients (17.1%), intermediate risk (D+/R) 14 patients (14.1%), or high risk - either (D-/R+) 31 patients (31.3%) or (D+/R+), 37 patients (37.3%). Cumulative incidence of CMV reactivation was 39% with a median time of 61 days (26-318). Three patients (3%) developed CMV disease. Two factors were associated with CMV reactivation: CMV serostatus group (low: 0% vs. intermediate: 29% vs. high: 50%; p=0.001) and the presence of grade II-IV acute GvHD (Hazard Ratio: HR=2.1 [1.1-3.9]). Thirty-six of the 39 patients (92%) with CMV reactivation did not present positive detection of CMV after a 21-day median duration preemptive treatment with ganciclovir. Cumulative incidence of day 100 grade II-IV acute GvHD, 1-year chronic GvHD and day 100 transplantation related mortality (TRM) were 37%, 36% and 9%, respectively. CMV reactivation and serostatus were not associated with increased GvHD and TRM or short survival. Only the presence of acute GvHD as a time dependent variable was significantly associated with increased TRM (p=0.005). Two-year overall and progression free survival were 56% and 34%, respectively. Donor and recipient CMV serostatus and acute GvHD are independent factors for increased CMV reactivation in high-risk MM patients undergoing RIC Allo-SCT. However, we did not find any influence of CMV reactivation on post transplantation outcome. CMV monitoring and pre-emptive treatment strategy could in part explain these results. Novel prophylactic measures such as immunotherapy and drug prophylaxis need to be considered in this group of patients, warranting further prospective studies. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Da] Date of entry for processing: 130513 [St] Status: PubMed-not-MEDLINE [do] DOI: 10.4084/MJHID.2013.026

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[PMID]: 23572582 [Au] Autor: Zawislak CL; Beaulieu AM; Loeb GB; Karo J; Canner D; Bezman NA; Lanier LL; Rudensky AY; Sun JC [Ad] Address: Immunology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065 and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143. [Ti] Title: Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. [So] Source: Proc Natl Acad Sci U S A;110(17):6967-72, 2013 Apr 23. [Is] ISSN: 1091-6490 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Natural killer (NK) cells function in the recognition and destruction of host cells infected with pathogens. Many regulatory mechanisms govern the potent responses of NK cells, both at the cellular and molecular level. Ablation of microRNA (miRNA) processing enzymes demonstrated that miRNAs play critical roles in NK cell differentiation and function; however, the role of individual miRNAs requires further investigation. Using mice containing a targeted deletion of microRNA-155 (miR-155), we observed defects in NK cell maintenance and maturation at steady state, as well as in homeostatic proliferation in lymphopenic mice. In addition, we discovered that miR-155 is up-regulated in activated NK cells during mouse cytomegalovirus (MCMV) infection in response to signals from the proinflammatory cytokines IL-12 and IL-18 and through signal transducer and activator of transcription 4 (STAT4) signaling. Although miR-155 was found to be dispensable for cytotoxicity and cytokine production when triggered through activating receptors, NK cells lacking miR-155 exhibited severely impaired effector and memory cell numbers in both lymphoid and nonlymphoid tissues after MCMV infection. We demonstrate that miR-155 differentially targets Noxa and suppressor of cytokine signaling 1 (SOCS1) in NK cells at distinct stages of homeostasis and activation. NK cells constitutively expressing Noxa and SOCS1 exhibit profound defects in expansion during the response to MCMV infection, suggesting that their regulation by miR-155 promotes antiviral immunity. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1304 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1073/pnas.1304410110

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[PMID]: 23467597 [Au] Autor: Edelmann A; Eichenlaub U; Lepek S; Krüger DH; Hofmann J [Ad] Address: Labor Berlin-Charité Vivantes GmbH, Virology, Berlin, Germany. [Ti] Title: Performance of the MagNA Pure 96 System for Cytomegalovirus Nucleic Acid Amplification Testing in Clinical Samples. [So] Source: J Clin Microbiol;51(5):1600-1, 2013 May. [Is] ISSN: 1098-660X [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: This report shows the performance of MagNA Pure 96 automated nucleic acid extraction for the quantitative detection of cytomegalovirus DNA in clinical samples by real-time PCR. The obtained results demonstrate that this workflow is characterized by high sensitivity and linearity and ensures reliable, reproducible clinical diagnostics. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1304 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1128/JCM.03289-12

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[PMID]: 23331429 [Au] Autor: Katsolis JG; Bosch W; Heckman MG; Diehl NN; Shalev JA; Pungpapong S; Gonwa TA; Hellinger WC [Ad] Address: Division of Infectious Diseases, Mayo Clinic Florida, Jacksonville, Florida 32224, USA. [Ti] Title: Evaluation of risk factors for cytomegalovirus infection and disease occurring within 1 year of liver transplantation in high-risk patients. [So] Source: Transpl Infect Dis;15(2):171-80, 2013 Apr. [Is] ISSN: 1399-3062 [Cp] Country of publication: Denmark [La] Language: eng [Ab] Abstract: BACKGROUND: Recent studies have demonstrated that cytomegalovirus (CMV) infection and disease are associated with increased risk of graft loss and death in high-risk (donor CMV seropositive/recipient CMV seronegative) liver transplant recipients (LTR) despite effective antiviral chemoprophylaxis. Predictors of CMV infection and disease in this important population are incompletely defined. METHODS: A retrospective cohort study of 227 high-risk first LTR who received primary anti-CMV chemoprophylaxis during the first 100 days after transplant was performed. A large number of patient, donor, operative, and post-transplant potential risk factors were collected. Associations of potential risk factors for CMV infection or disease that occurred during the first year after transplant were assessed using Cox regression models. After Bonferroni adjustment for multiple testing, P-values ≤0.00125 (associations with CMV infection) and ≤0.00122 (associations with CMV disease) were considered as statistically significant. RESULTS: CMV infection and disease occurred in 91 (40%) and 43 (19%) of LTR, respectively. In multivariable analysis, increased risk of CMV infection was observed for patients with lower model for end-stage liver disease (MELD) score (P = 0.025), lower total bilirubin (P = 0.014), and longer operative time (P = 0.038), whereas increased risk of CMV disease was seen in patients with lower MELD score (P = 0.026), lower total bilirubin (P = 0.044), and lower international normalized ratio (P = 0.043). However, after adjustment for multiple testing, none of these findings approached statistical significance. CONCLUSION: Our results suggest that interventions designed to prevent CMV infection and disease should be applied to all high-risk LTR until more definitive predictors of these complications are identified. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1304 [Js] Journal subset: IM [St] Status: In-Process [do] DOI: 10.1111/tid.12050

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[PMID]: 23230972 [Au] Autor: Hammond SP; Martin ST; Roberts K; Gabardi S; Fuhlbrigge AL; Camp PC; Goldberg HJ; Marty FM; Baden LR [Ad] Address: Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. shammond2@partners.org [Ti] Title: Cytomegalovirus disease in lung transplantation: impact of recipient seropositivity and duration of antiviral prophylaxis. [So] Source: Transpl Infect Dis;15(2):163-70, 2013 Apr. [Is] ISSN: 1399-3062 [Cp] Country of publication: Denmark [La] Language: eng [Ab] Abstract: BACKGROUND: A recent randomized trial demonstrated that 1 year of antiviral prophylaxis for cytomegalovirus (CMV) after lung transplantation is superior to 3 months of treatment for prevention of CMV disease. However, it is uncertain if a shorter duration of prophylaxis might result in a similar rate of CMV disease among select lung transplant (LT) recipients who are at lower risk for CMV disease, based on baseline donor (D) and recipient (R) CMV serologies. METHODS: We retrospectively assessed incidence, cumulative probability, and predictors of CMV disease and viremia in LT recipients transplanted between July 2004 and December 2009 at our center, where antiviral CMV prophylaxis for 6-12 months is standard. RESULTS: Of 129 LT recipients, 94 were at risk for CMV infection based on donor CMV seropositivity (D+) or recipient seropositivity (R+); 14 developed CMV disease (14.9%): 11 with CMV syndrome, 2 with pneumonitis, and 1 with gastrointestinal disease by the end of follow-up (October 2010); 17 developed asymptomatic CMV viremia (18.1%). The cumulative probability of CMV disease was 17.4% 18 months after transplantation. CMV D+/R- recipients who routinely received 1 year of prophylaxis were more likely to develop CMV disease compared with D+/R+ or D-/R+ recipients, who routinely received 6 months of prophylaxis (12/45 vs. 2/25 vs. 0/24, P = 0.005). Recipients who stopped CMV prophylaxis before 12 months (in D+/R- recipients) and 6 months (in R+ recipients) tended to develop CMV disease more than those who did not (9/39 vs. 3/41, P = 0.06). CONCLUSIONS: On a 6-month CMV prophylaxis protocol, few R+ recipients developed CMV disease in this cohort. In contrast, despite a 12-month prophylaxis protocol, D+/R- LT recipients remained at highest risk for CMV disease. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1304 [Js] Journal subset: IM [St] Status: In-Process [do] DOI: 10.1111/tid.12036

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