Database : MEDLINE
Search on : dysuria [Words]
References found : 3821 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 383 go to page                         

  1 / 3821 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29505534
[Au] Autor:Wu X; Yu C; Li T; Lin L; Xu Q; Zhu Q; Ye L; Gao X
[Ad] Address:Department of Urology, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, PR China.
[Ti] Title:Obesity was an independent risk factor for febrile infection after prostate biopsy: A 10-year single center study in South China.
[So] Source:Medicine (Baltimore);97(1):e9549, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:To detect the best antibiotic protocol for prostate biopsy and to assess the potential risk factors postbiopsy in Chinese patients.A total of 1526 patients underwent biopsy were assessed retrospectively. The effect of 3 antibiotic protocols was compared, including fluoroquinolone (FQ) monotherapy, third-generation cephalosporin combined with FQ and targeted antibiotics according to the prebiopsy rectal swab culture result. Postbiopsy infection (PBI) was defined as fever and/or active urinary tract symptoms such as dysuria or frequency with pyuria and/or leucocytosis, sepsis is defined as the presence of clinically or microbiologically documented infection in conjunction with systemic inflammatory response syndrome. The relationship between infections and clinical characteristics of patients was assessed. Data were first picked out in univariate analysis and then enter multivariate logistic regression.Thirty-three (2.2%) patients developed febrile infection. The combination antibiotic prophylaxis could significantly decrease the rate of PBI than FQ monotherapy (1.0% vs 4.0%, P = .000). The infection rate of the targeted antibiotic group was 1.1%, but there was no significant statistic difference compared with FQ alone (P = .349). Escherichia coli was the most predominant pathogen causing infection. Rectal swab revealed as high as 47.1% and 36.0% patients harbored FQ resistant and ESBL-producing organisms, respectively. In univariate analysis, overweight (BMI between 25 and 28 kg/m), obesity (BMI > 28 kg/m), diabetes were picked out as potential risk factors. Obesity remained as risk factor (OR = 12.827, 95% CI: 0.983-8.925, P = .001) while overweight and diabetes were close to significance (P = .052, .053, respectively).The combined cephalosporin with FQ prophylaxis could significantly decrease the risk of infectious complications. Obesity was an independent risk factor for PBI.
[Mh] MeSH terms primary: Anti-Bacterial Agents/therapeutic use
Antibiotic Prophylaxis
Obesity/complications
Prostate/surgery
Prostatitis/prevention & control
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Biopsy/adverse effects
Cephalosporins/therapeutic use
China
Fluoroquinolones/therapeutic use
Humans
Infection/etiology
Male
Middle Aged
Prostatitis/etiology
[Pt] Publication type:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Cephalosporins); 0 (Fluoroquinolones)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009549

  2 / 3821 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29522291
[Au] Autor:Pazeto CL; Nascimento FJ; Santiago LHS; Glina S
[Ad] Address:Departamento de Urologia, Faculdade de Medicina do ABC (FMABC), Santo Andr, SP, Brasil.
[Ti] Title:Idiosyncratic reaction after injection of polyacrylate - polyalcohol copolymer.
[So] Source:Int Braz J Urol;44, 2018 Mar 09.
[Is] ISSN:1677-6119
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:CONTEXT: Polyacrylate-polyalcohol copolymer is a synthetic product, non-biodegradable, with low rate of therapeutic failure and lower incidence of reactions at the site of injection, when compared to biodegradable agents. We report an unprecedent, exuberant and persistent inflammatory reaction following injection of that substance. PATIENT: A 17 years-old patient with vesico-ureteral reflux and complete pyelocaliceal right duplication was submitted to treatment with polyacrylate-polyalcohol copolymer (STING technique). In the seventh day of post-operatory, she presented intense dysuria and hypogastric pain, without laboratory exams alterations; a symptomatic treatment was started. After two months, the symptoms persisted and an ultrasound detected thickening of bladder wall close to the uretero-vesical junction. After that exam, a cystostopic biopsy showed epithelial hyperplasia with increased edema of lamina propria, suggesting an adverse reaction to the polymer. After four months, there was complete remission, but the reflux persisted with the same grade. HYPOTHESIS: This is an unprecedent reaction following injection of this copolymer. The presence of characteristics such as absence of infection, temporal relation between treatment and beginning of symptoms, and detection of epithelial hyperplasia at the local of injection reinforce the hypothesis of association of the substance and adverse reaction. In that patient, important complains motivated early investigation of urinary tract, that confirmed those aspects. Maybe if that reaction had occurred in patients with lower capacity of expression (such as in infants) it would be unnoticed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1590/S1677-5538.IBJU.2017.0446

  3 / 3821 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29489699
[Au] Autor:Qiu Y; Liu Y; Ren W; Ren J
[Ad] Address:Department of General Practice, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
[Ti] Title:Prostatic cyst in general practice: A case report and literature review.
[So] Source:Medicine (Baltimore);97(9):e9985, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Prostatic cyst is a rare disease of the prostate especially in general practice. As it is often asymptomatic, how to manage it is still unfamiliar with, general practitioners (GPs). PATIENT CONCERNS: The 24-year-old man presented with left back discomfort for 1 week without severe pain, dysuria, or fever. DIAGNOSES: Ultrasonography revealed the presence of a 1414 mm cystic lesion. INTERVENTIONS: The patient was given the medicine and regular follow-up. OUTCOMES: Several days later, he recovered without lower back discomfort. LESSONS: Patients with prostatic cyst of small size and no symptom should be follow-up regularly. Although prostatic cyst of progressive symptoms, large size (2.5 cm or larger), or high serum prostate-specific antigen (PSA) should be timely referred to urological specialists.
[Mh] MeSH terms primary: Cysts/complications
General Practice/methods
Low Back Pain/etiology
Prostatic Diseases/complications
[Mh] MeSH terms secundary: Cysts/diagnostic imaging
Humans
Low Back Pain/diagnostic imaging
Male
Prostatic Diseases/diagnostic imaging
Ultrasonography
Young Adult
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009985

  4 / 3821 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29194531
[Au] Autor:Roman H; Bubenheim M; Huet E; Bridoux V; Zacharopoulou C; Dara E; Collinet P; Tuech JJ
[Ad] Address:Expert Center in the Diagnosis and Multidisciplinary Management of Endometriosis, Rouen University Hospital, 76031 Rouen, France.
[Ti] Title:Conservative surgery versus colorectal resection in deep endometriosis infiltrating the rectum: a randomized trial.
[So] Source:Hum Reprod;33(1):47-57, 2018 Jan 01.
[Is] ISSN:1460-2350
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:STUDY QUESTION: Is there a difference in functional outcome between conservative versus radical rectal surgery in patients with large deep endometriosis infiltrating the rectum 2 years postoperatively? SUMMARY ANSWER: No evidence was found that functional outcomes differed when conservative surgery was compared to radical rectal surgery for deeply invasive endometriosis involving the bowel. WHAT IS KNOWN ALREADY: Adopting a conservative approach to the surgical management of deep endometriosis infiltrating the rectum, by employing shaving or disc excision, appears to yield improved digestive functional outcomes. However, previous comparative studies were not randomized, introducing a possible bias regarding the presumed superiority of conservative techniques due to the inclusion of patients with more severe deep endometriosis who underwent colorectal resection. STUDY DESIGN SIZE, DURATION: From March 2011 to August 2013, we performed a 2-arm randomized trial, enroling 60 patients with deep endometriosis infiltrating the rectum up to 15 cm from the anus, measuring more than 20 mm in length, involving at least the muscular layer in depth and up to 50% of rectal circumference. No women were lost to follow-up. PARTICIPANTS/MATERIALS, SETTING, METHODS: Patients were enroled in three French university hospitals and had either conservative surgery, by shaving or disc excision, or radical rectal surgery, by segmental resection. Randomization was performed preoperatively using sequentially numbered, opaque, sealed envelopes, and patients were informed of the results of randomization. The primary endpoint was the proportion of patients experiencing one of the following symptoms: constipation (1 stool/>5 consecutive days), frequent bowel movements (≥3 stools/day), defecation pain, anal incontinence, dysuria or bladder atony requiring self-catheterization 24 months postoperatively. Secondary endpoints were the values of the Visual Analog Scale (VAS), Knowles-Eccersley-Scott-Symptom Questionnaire (KESS), the Gastrointestinal Quality of Life Index (GIQLI), the Wexner scale, the Urinary Symptom Profile (USP) and the Short Form 36 Health Survey (SF36). MAIN RESULTS AND THE ROLE OF CHANCE: A total of 60 patients were enroled. Among the 27 patients in the conservative surgery arm, two were converted to segmental resection (7.4%). In each group, 13 presented with at least one functional problem at 24 months after surgery (48.1 versus 39.4%, OR = 0.70, 95% CI 0.22-2.21). The intention-to-treat comparison of the overall scores on KESS, GIQLI, Wexner, USP and SF36 did not reveal significant differences between the two arms. Segmental resection was associated with a significant risk of bowel stenosis. LIMITATIONS REASONS FOR CAUTION: The inclusion of only large infiltrations of the rectum does not allow the extrapolation of conclusions to small nodules of <20 mm in length. The presumption of a 40% difference favourable to conservative surgery in terms of postoperative functional outcomes resulted in a lack of power to demonstrate a difference for the primary endpoint. WIDER IMPLICATIONS OF THE FINDINGS: Conservative surgery is feasible in patients managed for large deep rectal endometriosis. The trial does not show a statistically significant superiority of conservative surgery for mid-term functional digestive and urinary outcomes in this specific population of women with large involvement of the rectum. There is a higher risk of rectal stenosis after segmental resection, requiring additional endoscopic or surgical procedures. STUDY FUNDING/COMPETING INTEREST(S): This work was supported by a grant from the clinical research programme for hospitals (PHRC) in France. The authors declare no competing interests related to this study. TRIAL REGISTRATION NUMBER: This study is registered with ClinicalTrials.gov, number NCT 01291576. TRIAL REGISTRATION DATE: 31 January 2011. DATE OF FIRST PATIENT'S ENROLMENT: 7 March 2011.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1093/humrep/dex336

  5 / 3821 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29223275
[Au] Autor:Correa V; Vintch J; Lanks C
[Ad] Address:Division of Pulmonary and Critical Care Physiology and Medicine, Harbor-UCLA Medical Center, Torrance, CA.
[Ti] Title:A 26-Year-Old Man From Mexico With Headaches, Dysuria, and a Right ScrotalMass.
[So] Source:Chest;152(6):e147-e150, 2017 12.
[Is] ISSN:1931-3543
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CASE PRESENTATION: A 26-year-old man with no medical history was admitted to the hospital for evaluation of his change in mental status. He was noted to be agitated at work and had difficulty walking for 2days before being brought in to the ED by his family. According to his uncle, the patient had been complaining of a headache and pain with urination for approximately 1week. He was born in Guerrero, Mexico (a small farm town), and moved to Los Angeles, California, in2008.
[Mh] MeSH terms primary: Dysuria/etiology
Headache/etiology
Hydrocephalus/complications
Mycobacterium bovis/isolation & purification
Scrotum/diagnostic imaging
Tuberculosis, Male Genital/diagnosis
[Mh] MeSH terms secundary: Adult
DNA, Bacterial/analysis
Diagnosis, Differential
Dysuria/diagnosis
Headache/diagnosis
Humans
Hydrocephalus/diagnosis
Magnetic Resonance Imaging
Male
Mycobacterium bovis/genetics
Scrotum/microbiology
Tuberculosis, Male Genital/microbiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA, Bacterial)
[Em] Entry month:1712
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171211
[St] Status:MEDLINE

  6 / 3821 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29500487
[Au] Autor:Le Fouler A; Hamy A; Barbieux J; Souday V; Bigot P; Le Naoures P; Jaouen R; Brochard C; Venara A
[Ad] Address:Department of Digestive and Endocrinal Surgery, CHU Angers, 4 rue Larrey, 49933, Angers, France.
[Ti] Title:Long-term functional outcomes of perineal gangrene: worse than expected?-an observational retrospective study.
[So] Source:Int J Colorectal Dis;, 2018 Mar 02.
[Is] ISSN:1432-1262
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: For survivors of perineal gangrene (PG), quality of life and functional prognosis of pelvic functions are probably overestimated. The aim of this study was to report long-term anal and urinary sphincter dysfunctions, sexual sequelae, and patients' quality of life after treatment of perineal gangrene. METHODS: This retrospective observational study was conducted in one university hospital over 16years. Seventy-three patients experienced PG; 22 were subject to long-term follow-up. Three questionnaires were sent to patients to assess pelvic dysfunction and quality of life: the GIQLI, the Cleveland Incontinence Score, and the USP score for urinary dysfunction. Sexual sequelae were considered if orchiectomy or penile resection for male patients and vulvar resection for female patients were performed. RESULTS: Of the 72 patients included, seven died before discharge (9.7%) and at least 14 died during follow-up (19.4%), despite a mean age of 62years ( 13). Among the surviving patients, seven experienced an alteration of their quality of life (44%) (GIQLI < 96). Six patients still had a colostomy, and among the remaining patients, 11 experienced minimal to mild incontinence (68.7%), while one experienced constipation (6.2%). One patient suffered from urinary incontinence (4.5%), and six suffered from dysuria (27.3%). Three male patients (14%) underwent an orchiectomy, and one female patient (100%) underwent a vulvar resection. CONCLUSION: PG leads to a high rate of anal and urinary dysfunctions. Urinary dysfunctions are taken into account and treated; however, anal incontinence is not investigated even though it could lead to decreased quality of life.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher
[do] DOI:10.1007/s00384-018-2999-5

  7 / 3821 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29480840
[Au] Autor:De Nola R; Di Naro E; Schonauer LM; Lucarelli G; Battaglia M; Fiore MG; Mastrolia SA; Loverro G
[Ad] Address:Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic.
[Ti] Title:Clinical management of a unique case of PNET of the uterus during pregnancy, and review of the literature.
[So] Source:Medicine (Baltimore);97(2):e9505, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms characterized by small round cells of neuroepithelial origin. They usually involve bone and soft tissues, and have a higher incidence in childhood. PATIENT CONCERNS: In this case report, we describe the obstetric and oncological outcome of a huge mass diagnosed as a leiomyoma in a 39-year-old pregnant woman who complained of low back pain, dysuria, and urinary frequency at 22 weeks of gestation. DIAGNOSES: During the 25th week of pregnancy, the patient was referred to our hospital at night with severe anemia and suspected hemoperitoneum. She underwent an emergency caesarean section, delivering a female fetus weighing 400 g, with an Apgar score of 7 at 1 minute and 9 at 5 minutes. INTERVENTION: During surgery, we found a huge uterine sarcoma-like metastatic tumor, invading the pelvic peritoneum and parametria bilaterally; the adnexae seemed disease-free. We performed a type B radical hysterectomy, bilateral salpingo-oophorectomy, pelvic peritonectomy, omentectomy, appendectomy, and excision of a bulky lymph node. Seven days after delivery, staging computed tomography (CT) scan demonstrated a large lombo-aortic lymph node compressing the left renal vein and we completed debulking with a second surgery, including diaphragmatic peritonectomy and excision of a huge lymph node by lombo-aortic lymphadenectomy, requiring partial reconstruction of an infiltrated renal vein. OUTCOME: Ten days after the second surgery, echo-color Doppler showed a regular microcirculation in the left kidney. The patient was discharged after 10 days, and the baby after 1 month, both in good health.Histological examination revealed a uterine body cPNET (central primitive neuroectodermal tumor) orienting the clinical management toward chemotherapy with cisplatin and etoposide. LESSONS: PNETs are aggressive neoplasms, usually diagnosed at an advanced stage. Due to their low incidence, universally accepted guidelines are still unavailable. Radical surgery leaving no macroscopic residual disease is mandatory in advanced stages. A good fertility-sparing procedure can be performed only in young women at early stages of disease, when the wish for childbearing is not yet fulfilled.
[Mh] MeSH terms primary: Neuroectodermal Tumors, Primitive/surgery
Pregnancy Complications, Neoplastic/surgery
Uterine Neoplasms/surgery
[Mh] MeSH terms secundary: Adult
Cesarean Section
Emergency Medical Services
Female
Humans
Infant, Newborn
Neuroectodermal Tumors, Primitive/diagnostic imaging
Neuroectodermal Tumors, Primitive/drug therapy
Neuroectodermal Tumors, Primitive/pathology
Pregnancy
Pregnancy Complications, Neoplastic/diagnostic imaging
Pregnancy Complications, Neoplastic/drug therapy
Pregnancy Complications, Neoplastic/pathology
Uterine Neoplasms/diagnostic imaging
Uterine Neoplasms/drug therapy
Uterine Neoplasms/pathology
Uterus/diagnostic imaging
Uterus/pathology
Uterus/surgery
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009505

  8 / 3821 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29307483
[Au] Autor:Valentini FA; Marti BG; Robain G
[Ad] Address:Service de mdecine physique et de la radaptation, universit Pierre-et-Marie-Curie, hpital Rothschild, 5, rue Santerre, 75012 Paris, France. Electronic address: francoise.valentini@rth.aphp.fr.
[Ti] Title:Do urodynamics provide a better understanding of voiding disorders in women over 80?
[So] Source:Prog Urol;28(4):230-235, 2018 Mar.
[Is] ISSN:1166-7087
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:AIMS: Population ageing has as consequence an increasing number of women older than 80 years with lower urinary tract symptoms (LUTS). Despite old age, urodynamic study is often performed to diagnose the cause of LUTS. Our purpose is to discuss the contribution of urodynamics to manage that population. METHODS: Urodynamic studies of 169 consecutive women older than 80 years, respectively 124 non-neurological (non-N) and 45 neurological (N), were retrospectively analysed. RESULTS: Number of co-morbidities was lower in non-N (2.5 vs. 3.1) with predominance of cardiovascular and endocrinology while musculo-skeletal, cognitive and previous pelvic surgery predominated in N. Among main complaint, incomplete retention or dysuria was more frequent in N while incontinence and frequency were predominant in non-N. More frequent urodynamic diagnosis (UD) was "normal" i.e. non contributive (25.0%) and intrinsic sphincter deficiency (ISD=21.7%) in non-N, detrusor overactivity (DO=42.2%) and detrusor underactivity (DU=38.8%) in N. In non-N, there were 94 treatment proposals based on the complaint when UD was "normal" and on UD for DO, DU and ISD. In N, treatment proposals were mainly prompted voiding or self-catheterization based on DU diagnosis. CONCLUSION: Usefulness of urodynamics to manage LUT dysfunction in women older than 80 y is greatly dependent on their neurological status. In non-neurological women this is non debatable but proposed treatment needs to take into account existing co-morbidities. In neurological women the main usefulness is to unmask DU and to propose the best management in order to avoid complete retention. LEVEL OF EVIDENCE: 4.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:In-Process

  9 / 3821 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Clinical Trials Registry
Full text

[PMID]: 29429593
[Au] Autor:Papi A; Vestbo J; Fabbri L; Corradi M; Prunier H; Cohuet G; Guasconi A; Montagna I; Vezzoli S; Petruzzelli S; Scuri M; Roche N; Singh D
[Ad] Address:Research Centre on Asthma and COPD, University of Ferrara, Ferrara, Italy. Electronic address: ppa@unife.it.
[Ti] Title:Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial.
[So] Source:Lancet;, 2018 Feb 09.
[Is] ISSN:1474-547X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Evidence is scarce on the relative risk-benefit of inhaled triple therapy, consisting of inhaled corticosteroid, long-acting muscarinic antagonist, and long-acting -agonist, versus dual bronchodilation for chronic obstructive pulmonary disease (COPD). We aimed to compare a single-inhaler triple combination of beclometasone dipropionate, formoterol fumarate, and glycopyrronium (BDP/FF/G) versus a single-inhaler dual bronchodilator combination of indacaterol plus glycopyrronium (IND/GLY) in terms of the rate of moderate-to-severe COPD exacerbations over 52 weeks of treatment. METHODS: This randomised, parallel-group, double-blind, double-dummy study was done at 187 sites across 17 countries. Eligible patients had symptomatic COPD, severe or very severe airflow limitation, at least one moderate or severe exacerbation in the previous year, and were receiving inhaled maintenance medication. After a 2 week run-in period with one inhalation per day of IND/GLY (85 g/43 g), patients were randomly assigned (1:1), via an interactive response technology system, to receive 52 weeks of treatment with two inhalations of extrafine BDP/FF/G (87 g/5 g/9 g) twice per day or one inhalation of IND/GLY (85 g/43 g) per day. Randomisation was stratified by country and severity of airflow limitation. The primary endpoint was the rate of moderate-to-severe COPD exacerbations across 52 weeks of treatment in all randomised patients who received at least one dose of study drug and had at least one post-baseline efficacy assessment. Safety was assessed in all patients who received at least one dose of study drug. This study is registered with ClinicalTrials.gov, number NCT02579850. FINDINGS: Between May, 29 2015, and July 10, 2017, 1532 patients received BDP/FF/G (n=764) or IND/GLY (n=768). Moderate-to-severe exacerbation rates were 050 per patient per year (95% CI 045-057) for BDP/FF/G and 059 per patient per year (053-067) for IND/GLY, giving a rate ratio of 0848 (0723-0995, p=0043) in favour of BDP/FF/G. Adverse events were reported by 490 (64%) of 764 patients receiving BDP/FF/G and 516 (67%) of 768 patients receiving IND/GLY. Pneumonia occurred in 28 (4%) patients receiving BDP/FF/G versus 27 (4%) patients receiving IND/GLY. One treatment-related serious adverse event occurred in each group: dysuria in a patient receiving BDP/FF/G and atrial fibrillation in a patient receiving IND/GLY. INTERPRETATION: In patients with symptomatic COPD, severe or very severe airflow limitation, and an exacerbation history despite maintenance therapy, extrafine BDP/FF/G significantly reduced the rate of moderate-to-severe exacerbations compared with IND/GLY, without increasing the risk of pneumonia. FUNDING: Chiesi Farmaceutici.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Cl] Clinical Trial:ClinicalTrial
[St] Status:Publisher

  10 / 3821 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29487099
[Au] Autor:Hellerstein LH; Sacks SM; Hellerstein DK
[Ad] Address:University of Miami Miller School of Medicine, Miami, Florida, USA.
[Ti] Title:Obstructive uropathy from complete bladder and bilateral ureteral incarceration within an inguinal hernia.
[So] Source:BMJ Case Rep;2018, 2018 Feb 27.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A 59-year-old man with a medical history of hypertension, gout and obesity presented to the hospital with a chief complaint of worsening scrotal oedema. The patient endorsed associated symptoms of decreased force of stream on urination, stranguria and hesitancy with slight dysuria. Physical exam showed an effaced umbilicus and phallus with a hidden scrotum estimated to be 302030 cm in size. Imaging and lab findings led to a diagnosis of total bladder herniation within an incarcerated right inguinal hernia. Surgical repair of the inguinal hernia and replacement of the bladder and ureters led to a resolution of urinary symptoms with no evidence of vesicoureteral reflux or urinary retention.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Process


page 1 of 383 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information