Database : MEDLINE
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[PMID]: 29507276
[Au] Autor:Rodríguez Castellanos FE; Domínguez Quintana F; Soto Abraham V; Mancilla Urrea E
[Ad] Address:Department of Nephrology and Renal Transplantation, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico. eugencast@gmail.com.
[Ti] Title:Classification of Acute Rejection Episodes in Kidney Transplantation: a Proposal Based on Factor Analysis.
[So] Source:Iran J Kidney Dis;12(2):123-131, 2018 Mar.
[Is] ISSN:1735-8604
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Kidney transplantation is considered the ideal treatment for end-stage renal disease. Acute rejection can influence graft survival. The aim of this study was to propose a classification system for acute rejection based on factor analysis. MATERIALS AND METHODS: Data were collected from kidney transplant recipients with acute rejection diagnosis based on standard histological variables, the presence of peritubular eosinophils, and immunolabeling for lysozyme and myeloperoxidase in kidney tissue. Factor analysis was employed for data reduction and generation of a new case classification, with orthogonal rotation as a strategy to simplify factors, and principal component analysis was used as an extraction method. RESULTS: Seventy-nine kidney biopsies were obtained from 74 patients. The total population was divided into humoral rejection (39.2%), cellular rejection (34.1%), and mixed acute rejection (26.7%). No significant differences were found between the three groups in clinical and biochemical variables. We extracted 4 factors using factor analysis. The 1st factor was characterized by the presence of capillaritis, plasma cells infiltration, tubulitis, and inflammation. The 2nd factor included positivity for lysozyme and myeloperoxidase, while the 3rd factor included the presence of eosinophils and glomerulitis. The 4th component consisted of the presence of C4d and endarteritis. The cases belonging to the 3rd factor showed the greatest increase in serum creatinine. The cases belonging to the 4th factor exhibited greater urinary excretion of proteins. CONCLUSIONS: This proposal of classification of acute rejection could contribute to evaluate the prognosis of kidney transplant recipients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Data-Review

  2 / 1076 MEDLINE  
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[PMID]: 29339678
[Au] Autor:Sinan ÜY; Dirlik Serim B; Yildirim R; Çetinarslan Ö; Küçükoglu MS
[Ad] Address:Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey. drumityasar@hotmail.com.
[Ti] Title:Endarteritis of coarctation of the aorta diagnosed with PET-CT.
[So] Source:Turk Kardiyol Dern Ars;46(1):66-68, 2018 01.
[Is] ISSN:1308-4488
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:Infective endocarditis (IE) is an infectious disease that affects the endothelium of the large intrathoracic vessels, heart valves, and intra-cardiac foreign body material. A 20-year-old woman was admitted to the cardiology department with complaints of fever and palpitations. Transthoracic echocardiography revealed a bicuspid aortic valve, aortic root enlargement, and aortic coarctation. Transesophageal echocardiography revealed a bicuspid aortic valve, but there was no vegetation. Methicillin-sensitive Staphylococcus aureus was identified on a blood culture. 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) revealed increased intensive glucose uptake on the dilated aortic segment adjacent to the distal coarctation zone. Several reports have shown promising results for radio-labelled white blood cell single-photon emission computed tomography and 18F-FDG PET-CT imaging in IE. To our knowledge, this is the first described case in which PET-CT revealed endarteritis of the descending aorta in a patient without prosthetic material.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180123
[Lr] Last revision date:180123
[St] Status:In-Process
[do] DOI:10.5543/tkda.2017.68246

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[PMID]: 29279472
[Au] Autor:Yamamoto K; Ohmagari N
[Ad] Address:Disease Control and prevention Center, National Center for Global Health and Medicine, Japan.
[Ti] Title:Infective Endarteritis due to Staphylococcus capitis.
[So] Source:Intern Med;, 2017 Dec 27.
[Is] ISSN:1349-7235
[Cp] Country of publication:Japan
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171227
[Lr] Last revision date:171227
[St] Status:Publisher
[do] DOI:10.2169/internalmedicine.0070-17

  4 / 1076 MEDLINE  
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[PMID]: 29143686
[Au] Autor:Carretón E; Cerón JJ; Martínez-Subiela S; Tvarijonaviciute A; Caro-Vadillo A; Montoya-Alonso JA
[Ad] Address:Faculty of Veterinary Medicine, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Trasmontaña s/n, 35413-Arucas, Las Palmas, Gran Canaria, Spain. elena.carreton@ulpgc.es.
[Ti] Title:Acute phase proteins and markers of oxidative stress to assess the severity of the pulmonary hypertension in heartworm-infected dogs.
[So] Source:Parasit Vectors;10(Suppl 2):477, 2017 Nov 09.
[Is] ISSN:1756-3305
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Canine heartworm infection is characterized by pulmonary endarteritis and pulmonary hypertension (PH). The aim of the present study was to evaluate the relationship between PH with the concentrations of different positive (C-reactive protein [CRP] and haptoglobin [Hp]) and negative (albumin and paraoxonase-1 [PON-1]) acute phase proteins (APP), as well as the oxidative stress, by measuring glutathione peroxidase (GPx) and total antioxidant capacity (TAC) in 27 heartworm-infected dogs on Day 0 (diagnosis) and Day 120 (1 month after the last adulticide injection). Presence/absence of PH was determined by the Right Pulmonary Artery Distensibility (RPAD) Index. RESULTS: On Day 0, 62.9% of the dogs showed PH. Concentrations of CRP and Hp were higher in dogs with PH, especially in dogs with moderate-severe PH (P < 0.005 and P < 0.05, respectively). Albumin and PON-1 concentrations were higher in dogs without PH (P < 0.05 for albumin). On Day 120, 59.2% of the dogs presented with PH; CRP decreased while Hp increased (P < 0.005 and P < 0.05, respectively). Also, albumin and PON-1 rose, especially in absence of PH. There were not significant changes in the serum values of GPx and TAC. CONCLUSIONS: CRP and Hp have a potential prognostic role in dogs with dirofilariasis because increases in positive APP correlated with presence and severity of PH. CRP decreased, but Hp persisted at an elevated level in dogs with PH 1 month after the end of the adulticide treatment. CRP and Hp could work as early biomarkers of PH and be useful to stage the disease and to monitor the evolution of the patient and indirectly evaluate the persistence of arterial damage after the parasites have been eliminated. Albumin and PON-1 also showed potential value as markers of PH, although further research is necessary to determine its utility.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171122
[Lr] Last revision date:171122
[St] Status:In-Process
[do] DOI:10.1186/s13071-017-2426-8

  5 / 1076 MEDLINE  
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[PMID]: 29114392
[Au] Autor:Shafer K; Toma C; Galdys A
[Ad] Address:Critical Care Medicine, University of Pittsburgh Medical Center, Suite 1215, Kaufmann Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
[Ti] Title:A common pathogen in an uncommon site: coronary artery stent meticillin-resistant infection.
[So] Source:JMM Case Rep;4(9):e005110, 2017 Sep.
[Is] ISSN:2053-3721
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Coronary artery stents are an uncommon site for infection. Only a handful of case reports describe this condition, and is the most frequent pathogen. Although rare, coronary stent infections are associated with a high mortality rate. We describe the case of a 50-year-old man with a past medical history of seven prior meticillin-resistant (MRSA) infections over the previous 12 months, who presented with fever and was found to have persistent MRSA bacteraemia. During his hospital course, he developed chest pain and underwent coronary angiography, which revealed a left circumflex coronary to left atrium fistula, presumably due to endarteritis/sent infection. He was treated with combination parenteral antibiotics that were succeeded by oral suppressive therapy. Six months after his diagnosis of coronary stent infection, he suffered a fatal cardiac arrest. Coronary artery stents are an infrequent source of infection; when they occur, they are typically due to , have a high mortality and ideally are treated with surgical intervention.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171110
[Lr] Last revision date:171110
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1099/jmmcr.0.005110

  6 / 1076 MEDLINE  
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[PMID]: 29080766
[Au] Autor:Diosdado A; Gómez PJ; Morchón R; Simón F; González-Miguel J
[Ad] Address:Laboratory of Parasitology, Faculty of Pharmacy, University of Salamanca, Salamanca, Spain.
[Ti] Title:Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis.
[So] Source:Vet Parasitol;247:64-69, 2017 Nov 30.
[Is] ISSN:1873-2550
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Dirofilaria immitis is a mosquito-borne parasite that produces an inflammatory process in the wall of the blood vessels of its definitive host during cardiopulmonary dirofilariosis, known as proliferative endarteritis. Parasite antigens participate in the appearance of this inflammatory event, among other mechanisms through the over-activation of the host fibrinolytic system. Since Wolbachia, endosymbiont bacteria of filarial nematodes, is released into the vertebrate host when worms die, the aim of this work was to analyse the interaction between this bacteria and the host fibrinolytic system to complete the study of this part of the host-parasite relationships. For that purpose, the recombinant form of the major Wolbachia surface protein (rWSP) was cloned, sequenced and expressed and then, its ability to bind plasminogen and enhance the generation of plasmin was assessed. We demonstrated that rWSP is a conserved antigen within the family Onchocercidae with ability to bind plasminogen and stimulate plasmin generation in a tissue-plasminogen activator (t-PA) and lysine residues of the rWSP-dependent manner. These results indicate that the recruitment of plasminogen by Wolbachia and the possible excess of plasmin generated could contribute to exacerbate the pathological events occurred at the vascular level during cardiopulmonary dirofilariosis, as well as in other diseases caused by filarial nematodes that harbour Wolbachia, when the bacteria is released after the death of the worms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171029
[Lr] Last revision date:171029
[St] Status:In-Process

  7 / 1076 MEDLINE  
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[PMID]: 29035862
[Au] Autor:Gavrilovic P; Marinkovic D; Todorovic I; Gavrilovic A
[Ad] Address:.
[Ti] Title:First report of pneumonia caused by Angiostrongylus vasorum in a golden jackal.
[So] Source:Acta Parasitol;62(4):880-884, 2017 Dec 20.
[Is] ISSN:1896-1851
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Angiostrongylosis caused by metastrongyloid nematode Angiostrongylus vasorum is an emerging parasitic disease in Europe and the red fox (Vulpes vulpes) is considered as a main reservoir species for this parasite. Little is known about the role of other wild canids in the epidemiology of angiostrongylosis. The present paper provides the first description of pathomorphological lesions caused by A. vasorum in a golden jackal (Canis aureus). The paper describes a case of co-infection with A. vasorum and Dirofilaria immitis in a one-year-old female golden jackal, legally hunted near the City of Kovin, South Banat, Serbia. The postmortem examination revealed severe pneumonia, proliferative endarteritis, the presence of two adult males of D. immitis in the right atrium, and the presence of 15 adult forms of A. vasorum (11 females and 4 males) in the pulmonary arteries. Native microscopy of an impression smear of the lung tissue found numerous larvae compatible with the A. vasorum first larval stage. This paper provides the first evidence that angiostrongylosis exists in the golden jackal in Serbia and confirms that the golden jackal should be considered as a very suitable definitive host for A. vasorum. The results suggest the possibility that the golden jackal may act as reservoir species and as an important transmitter of A. vasorum larvae.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171016
[Lr] Last revision date:171016
[St] Status:In-Process

  8 / 1076 MEDLINE  
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[PMID]: 28979018
[Au] Autor:Rao AG; Swathi T; Hari S; Kolli A; Reddy UD
[Ad] Address:Department of Dermatology, SVS Medical College, Mahbubnagar, Telangana, India.
[Ti] Title:Malignant Syphilis in an Immunocompetent Adult Male.
[So] Source:Indian J Dermatol;62(5):524-527, 2017 Sep-Oct.
[Is] ISSN:1998-3611
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:The occurrence of malignant syphilis in an immunocompetent individual is rare. We present malignant syphilis in a 35-year-old immunocompetent male who presented with a 1-month history of noduloulcerative lesions on the torso. Examination revealed multiple pustules, nodules, and deep-seated ulcers distributed on the trunk, face, and upper and lower limbs. Characteristic morphology of lesions, positive serological tests for syphilis, characteristic histopathology, and resolution of lesions following institution of penicillin therapy confirmed the clinical diagnosis of malignant syphilis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171008
[Lr] Last revision date:171008
[St] Status:In-Data-Review
[do] DOI:10.4103/ijd.IJD_733_16

  9 / 1076 MEDLINE  
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[PMID]: 28801729
[Au] Autor:Comploj E; Pycha A
[Ad] Address:Abteilung für Urologie und Kinderurologie, Zentralkrankenhaus Bozen, Lorenz Böhler Straße 5, 39100, Bozen, Italien. complojevi94@yahoo.de.
[Ti] Title:Plastische Rekonstruktion des äußeren Genitales nach Fournier-Gangrän. [Plastic reconstruction of external genitalia after Fournier's gangrene].
[So] Source:Urologe A;56(10):1289-1292, 2017 Oct.
[Is] ISSN:1433-0563
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:Fournier's gangrene is a rapidly progressing necrotizing fasciitis restricted to the perineal and genital regions. Although rare, it is an acute life-threatening disease, requiring rapid radical surgical debridement and antibiotic treatment, resulting in large soft tissue defects. Various reconstructive methods for defect coverage are applied to satisfactorily reconstitute functionality and esthetics.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1708
[Cu] Class update date: 171117
[Lr] Last revision date:171117
[St] Status:In-Process
[do] DOI:10.1007/s00120-017-0477-2

  10 / 1076 MEDLINE  
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[PMID]: 28712642
[Au] Autor:Chaudet A; Goujon JM; Ghazali AD
[Ad] Address:Emergency Department, University Hospital of Poitiers, France.
[Ti] Title:Febrile abdominal pain revealing Horton's disease.
[So] Source:Am J Emerg Med;35(10):1583.e3-1583.e5, 2017 Oct.
[Is] ISSN:1532-8171
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Horton's disease is a systemic inflammatory vasculitis, usually found in persons over 50years old. It affects medium and large-sized arteries stemming from the external carotid, especially the superficial temporal arteries. It can affect extracranial large vessels but only rarely the aorta. Diagnosis of aortitis is difficult and its incidence is probably underestimated. CASE PRESENTATION: A 68-year-old Caucasian woman consulted in an emergency department for febrile abdominal pain with inflammatory syndrome. Abdomen was soft with right-side flank sensitivity. A contrast-enhanced CT scan showed aortitis from the descending aorta to the iliac arteries without complication. Because of age, clinical presentation and aortitis, Horton disease was suspected. The temporal artery biopsy showed a histological aspect of degenerative endarteritis with intimal thickening and luminal stenosis. High-dose corticosteroid therapy was introduced which improved clinical conditions and resulted in the amendment of the pain. DISCUSSION: In the present case, this patient had Horton's disease, based on 3 criteria of The American College of Rheumatology (age, temporal artery abnormalities and inflammatory syndrome) associated with aortitis. However, aortitis is a rare complication of Horton disease and is a major cause of mortality inasmuch as it can be complicated by aneurysm and dissection. It is unusual to diagnose Horton's disease from aortitis symptoms without complications. The aorta represents the most severe localization of Horton's disease. It should not be ignored in etiological hypotheses regarding febrile abdominal pain in the elderly. Corticosteroids should be started rapidly at high doses and temporal artery biopsy should be planned.
[Mh] MeSH terms primary: Abdominal Pain/etiology
Fever/etiology
Giant Cell Arteritis/complications
[Mh] MeSH terms secundary: Abdominal Pain/diagnosis
Aged
Biopsy
Diagnosis, Differential
Dose-Response Relationship, Drug
Female
Fever/diagnosis
Giant Cell Arteritis/diagnosis
Giant Cell Arteritis/drug therapy
Glucocorticoids/administration & dosage
Humans
Temporal Arteries/diagnostic imaging
Tomography, X-Ray Computed
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Glucocorticoids)
[Em] Entry month:1710
[Cu] Class update date: 171012
[Lr] Last revision date:171012
[Js] Journal subset:IM
[Da] Date of entry for processing:170718
[St] Status:MEDLINE


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