Database : MEDLINE
Search on : epithelium [Words]
References found : 251712 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 25172 go to page                         

  1 / 251712 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 25372542
[Au] Autor:Chaikitmongkol V; Bressler NM
[Ad] Address:*Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; and †Retina Division, Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
[Ti] Title:Intraretinal fibrosis in exudative diabetic macular edema after ranibizumab treatments.
[So] Source:Retin Cases Brief Rep;8(4):336-9, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To describe the clinical and optical coherence tomography findings of an eye with diabetic macular edema that developed intraretinal fibrosis in an area previously occupied by lipid accumulating after the intravitreous ranibizumab treatment. METHODS: Interventional case report. RESULTS: An 85-year-old man presented with diabetic macular edema involving the center of the macula with a half disk area of lipid inferotemporal to the macula. He received ranibizumab treatments after the principles of the Diabetic Retinopathy Clinical Research Network retreatment guidelines. After 12 doses of intravitreous ranibizumab injections over 20 months, macular edema resolved, visual acuity improved from 20/63 to 20/40, and the central subfield thickness decreased from 404 µm to 234 µm. As the edema resolved, the area of lipid did not expand toward the fovea but was replaced by fibrosis occupying the area of lipid, only smaller in extent. Optical coherence tomography scans showed an intraretinal, dome-shaped hyperreflective area corresponding to the fibrosis. CONCLUSION: This case report, to our knowledge, provides the first documentation of intraretinal fibrosis replacing an area of lipid associated with diabetic macular edema after anti-vascular endothelial growth factor therapy, as had been described previously following laser photocoagulation for diabetic macular edema. Unlike some previous reports of lipid accumulating within the fovea with subsequent fibrosis corresponding to the metaplastic retinal pigment epithelium on histopathology, with or without laser treatment, the lipid in this case did not expand into the fovea before the development of fibrosis, and optical coherence tomography confirmed that the fibrosis was located in the intraretinal rather than the subretinal pigment epithelium space.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0000000000000063

  2 / 251712 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25372534
[Au] Autor:Gelman R; Kiss S; Tsang SH
[Ad] Address:*Department of Ophthalmology, University of Southern California, Los Angeles, California; †Edward S. Harkness Eye Institute, College of Physicians and Surgeons, Columbia University, New York, New York; ‡Deparment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York; §Department of Ophthalmology, Weill Cornell Medical College, New York, New York; and ¶Barbara and Donald Jonas Laboratory of Stem Cell and Regenerative Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
[Ti] Title:Multimodal imaging in a case of deferoxamine-induced maculopathy.
[So] Source:Retin Cases Brief Rep;8(4):306-9, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report a case of deferoxamine-induced maculopathy and present the use of multimodal retinal imaging to study this disease entity. METHODS: This is an observational case report of one patient. Multimodal imaging with fundus autofluorescence, infrared imaging, and spectral domain optical coherence tomography was used to investigate the macular changes induced by deferoxamine toxicity. RESULTS: A 53-year-old man with history of ß-thalassemia presented with decreased vision in both eyes 1 month after initiating deferoxamine therapy. Infrared imaging showed areas of increased stippled infrared intensity through the macula. Fundus autofluorescence revealed diffuse areas of stippled hyperautofluorescence and hypoautofluorescence. Spectral domain optical coherence tomography changes included disruption of the ellipsoid zone, attenuation of the photoreceptors, and deposits within the retinal pigment epithelium. CONCLUSION: A case of deferoxamine-induced maculopathy was described and the use of multimodal retinal imaging to study this disease entity was presented.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0000000000000059

  3 / 251712 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25372428
[Au] Autor:Patel M; Vavvas DG
[Ad] Address:Retina Service, Mass Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.
[Ti] Title:Spontaneous resolution of a postvitrectomy macular hole retinal detachment.
[So] Source:Retin Cases Brief Rep;8(3):161-3, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: The purpose of this report was to describe a case of spontaneous resolution of a large postvitrectomy macular hole retinal detachment. METHODS: Case report and optical coherence tomography imaging. RESULTS: A 64-year-old man with history of macula-off retinal detachment and 4 previous vitrectomies in the left eye developed a macular hole and associated retinal detachment 3 months after his last vitreoretinal surgery. Two months later, examination revealed that the macular hole had spontaneously closed, and the retinal detachment had resolved. CONCLUSION: Spontaneous resolution of macular hole-associated retinal detachment in a previously vitrectomized eye has not been reported previously. Changes in tangential traction by the associated epiretinal membrane, improvement of the cystoid changes noted at the edge of the macular hole, and/or proliferation of glial tissue to bridge the hole, along with the absorption of the subretinal fluid by the retinal pigment epithelium pump contributed to this rare event have been hyphothesized.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0000000000000052

  4 / 251712 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25372332
[Au] Autor:Jung JJ; Mrejen S; Freund KB; Yannuzzi LA
[Ad] Address:*Department of Ophthalmology, New York University School of Medicine, New York, New York; †Vitreous Retina Macula Consultants of New York, New York, New York; ‡LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York; and §Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York.
[Ti] Title:Idiopathic multifocal choroiditis with peripapillary zonal inflammation: a multimodal imaging analysis.
[So] Source:Retin Cases Brief Rep;8(2):141-4, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report a case of idiopathic multifocal choroiditis with transient peripapillary zonal inflammation that was followed with multimodal imaging and explain the mechanism by which chorioretinal atrophy may occur. METHODS: Observational case report. Review of the clinical examination, ocular imaging, and progression of idiopathic multifocal choroiditis. RESULTS: A 30-year-old white myopic man presented with complaints of worsening vision and a loss of visual field for 1 month in his left eye. Using multimodal imaging, including wide-field imaging with fluorescein angiography, fundus autofluorescence, and high-definition spectral-domain optical coherence tomography, he was found to have a macula involving peripapillary zonal inflammation consistent with acute idiopathic multifocal choroiditis involving the outer photoreceptor layer, ellipsoid layer, retinal pigment epithelium, and choroid. This area of inflammation was monitored with multimodal imaging over 7 months and slowly improved along with the patient's vision. Imaging allowed us to view the development of chorioretinal scars from several, but not all, acute inflammatory white spots. CONCLUSION: Multifocal choroiditis is an inflammatory disorder affecting the outer photoreceptors, ellipsoid layer, retinal pigment epithelium, and choroid; and areas of acute inflammation may improve over time but can also leave permanent chorioretinal atrophy including focal lesions or peripapillary zonal atrophy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0000000000000026

  5 / 251712 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25372322
[Au] Autor:Dai Y; Jonas JB; Ling Z; Sun X
[Ad] Address:*Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China; †Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Heidelberg, Germany; and ‡State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China.
[Ti] Title:Temporal inferior vein submerging into intrachoroidal cavitation and gamma zone.
[So] Source:Retin Cases Brief Rep;8(2):110-2, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To describe the appearance of the temporal inferior vein submerging into the parapapillary region with characteristics of parapapillary gamma zone and parapapillary beta zone. METHODS: Ophthalmoscopy in a 28-year-old man showed a sagittally rotated optic nerve head with marked temporal inferior parapapillary atrophy, in which the temporal inferior vein appeared to partially disappear. RESULTS: Serial optical coherence tomography images showed from inferior to superior, an intrachoroidal cavitation covered by intact Bruch membrane with retinal pigment epithelium (fulfilling the criteria of parapapillary beta zone). The intrachoroidal cavitation continued into an area with opened Bruch membrane (fulfilling the definition of parapapillary gamma zone) and a lamellar defect of the deep scleral layer. The lamellar defect became perforated leading to an apparent herniation of the retinal tissue into the almost extraocular space. From this herniation site, the inferior temporal vessel trunk submerged into an intrascleral or extrascleral pathway in the direction to the optic disk while the defect in the deep scleral layer was closed. Finally, more superior, the intrachoroidal cavitation decreased in volume and extent while Bruch membrane was absent (gamma zone). CONCLUSION: This report describes an unusual course of the inferior temporal vessel trunk and an associated unusual anatomy of the parapapillary region with beta zone and gamma zone, and an additional defect in the deep scleral layer allowing the exit of the temporal inferior vessel trunk into the extrascleral space. The illustration may also show the usefulness of the differentiation between beta zone and gamma zone in the parapapillary region.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0000000000000016

  6 / 251712 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25372319
[Au] Autor:Van Bol L; Alami A; Benghiat FS; Rasquin F
[Ad] Address:Departments of *Ophthalmology, and †Hematology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
[Ti] Title:Spectral domain optical coherence tomography findings in early deferoxamine maculopathy: report of two cases.
[So] Source:Retin Cases Brief Rep;8(2):97-102, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To describe spectral domain optical coherence tomography features in two cases of early deferoxamine induced retinal toxicity. METHODS: Two patients complained of sudden bilateral visual loss and dyschromatopsia. Both suffered from acute myelocytic leukemia with severe aplastic anemia and were treated with intravenous deferoxamine for 1 month. First ophthalmologic exploration and follow-up included fundoscopic examination, fluorescence angiography, fundus autofluorescence, and spectral domain optical coherence tomography. RESULTS: Initially, both patients presented with a decreased visual acuity, inferior to 20/100. Fundus examination revealed a loss of transparency of the outer retina in the two cases. Autofluorescence pictures displayed hypoautofluorescence in the macular area, whereas fluorescein angiography unveiled an annular hyperfluorescence staining in the macular zone. Spectral domain optical coherence tomography showed a serous detachment of the neuroepithelium associated with photoreceptor outer segment elongation. Deferoxamine toxicity was immediately suspected and therapy promptly interrupted. One week later, both patients recovered visual acuity of 20/20 but retinal pigment epithelium (RPE) mottling was noticed in the macular areas. Spectral domain optical coherence tomography monitoring showed a progressive resolution of serous retinal detachment. Elongation of the photoreceptor outer segment disappeared but the RPE remained thickened, interrupted, and fragmented at different macular loci. CONCLUSION: Serous detachment of the neuroepithelium associated with photoreceptor outer segment elongation in the early stage of deferoxamine maculopathy is described for the first time. Early drug discontinuation allowed a fast resolution of the serous detachment but the typical RPE pigment mottling observed at the resolution phase was noticed 1 week later.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0000000000000013

  7 / 251712 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25372196
[Au] Autor:Meena M; Bhatia K
[Ad] Address:Departments of *Ophthalmic Plastics and Ocular Oncology, and †Vitreoretinal Services, L V Prasad Eye Institute, Visakhapatnam, India.
[Ti] Title:Combined hamartoma of retina and retinal pigment epithelium associated with ipsilateral congenital blepharoptosis: a rare association.
[So] Source:Retin Cases Brief Rep;8(1):4-6, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report a patient who had concomitant congenital hamartoma of the retinal pigment epithelium and retina and ipsilateral congenital blepharoptosis. METHODS: Case report. RESULTS: An 11-year-old male presented with left-sided congenital blepharoptosis and combined hamartoma of the retina and retinal pigment epithelium in the ipsilateral eye. The systemic examination was within normal limits. The diagnosis of combined hamartoma was established by typical ophthalmoscopic and optical coherence tomography findings. CONCLUSION: Congenital blepharoptosis may be associated with ipsilateral combined hamartoma of the retina and retinal pigment epithelium.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0b013e3182984286

  8 / 251712 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25166721
[Au] Autor:Hui E; Yeung CY; Lee PC; Woo YC; Fong CH; Chow WS; Xu A; Lam KS
[Ad] Address:Department of Medicine (E.H., C.-Y.Y., P.C.H.L., Y.-C.W., C.H.Y.F., W.-S.C., A.X., K.S.L.L., Queen Mary Hospital; Research Centre of Heart, Brain, Hormones, and Healthy Aging (E.H., A.X., K.S.L.L.); and State Key Laboratory of Pharmaceutical Biotechnology (A.X., K.S.L.L.), The University of Hong Kong, Hong Kong, China.
[Ti] Title:Elevated circulating pigment epithelium-derived factor predicts the progression of diabetic nephropathy in patients with type 2 diabetes.
[So] Source:J Clin Endocrinol Metab;99(11):E2169-77, 2014 Nov.
[Is] ISSN:1945-7197
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CONTEXT: Pigment epithelium-derived factor (PEDF), a circulating glycoprotein with antiangiogenic, antioxidative, and anti-inflammatory properties, protects against diabetic nephropathy (DN) in animal models. OBJECTIVE: We investigated whether circulating PEDF predicted the progression of DN in a 4-year prospective study. DESIGN, SETTING, AND PARTICIPANTS: Baseline plasma PEDF levels were measured in type 2 diabetic subjects recruited from the Hong Kong West Diabetes Registry. The role of PEDF in predicting chronic kidney disease (CKD) and albuminuria progression was analyzed using Cox regression analysis. MAIN OUTCOME MEASURE: We evaluated CKD progression, defined as deterioration in CKD staging and a 25% or greater drop in estimated glomerular filtration rate (eGFR) according to International Society of Nephrology statements. RESULTS: At baseline, plasma PEDF levels increased progressively with CKD staging (P for trend <.001; n = 1136). Among 1071 subjects with baseline CKD stage ≤3, plasma PEDF levels were significantly higher in those with CKD progression (n = 171) during follow-up than those without (P < .001). Baseline PEDF was independently associated with CKD progression (hazard ratio = 2.76; 95% confidence interval = 1.39-5.47; P = .004), adjusted for age, sex, waist circumference, diabetes duration, hemoglobin A1c, systolic blood pressure, use of antihypertensive drugs, C-reactive protein, and eGFR. Elevated baseline PEDF was also associated with the development of microalbuminuria/albuminuria in a subgroup with normoalbuminuria and eGFR >60 mL/min/1.73 m(2) (n = 462) at baseline (hazard ratio = 2.75; 95% confidence interval = 1.01-7.49; P < .05), even after adjustment for potential confounders. CONCLUSIONS: Elevated PEDF levels may represent a compensatory change in type 2 diabetic patients with renal disease and appear to be a useful marker for evaluating the progression of DN.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1210/jc.2014-2235

  9 / 251712 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25127091
[Au] Autor:Al-Jallad H; Palomo T; Moffatt P; Roughley P; Glorieux FH; Rauch F
[Ad] Address:Shriners Hospital for Children and McGill University, Montréal, Québec, Canada H3G 1A6.
[Ti] Title:Normal Bone Density and Fat Mass in Heterozygous SERPINF1 Mutation Carriers.
[So] Source:J Clin Endocrinol Metab;99(11):E2446-50, 2014 Nov.
[Is] ISSN:1945-7197
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CONTEXT: Homozygous mutations in SERPINF1 cause deficiency of pigment epithelium-derived factor (PEDF) and lead to osteogenesis imperfecta (OI) type VI, but it is not known whether heterozygous mutations in SERPINF1 cause a phenotype. OBJECTIVE: In the present study, we therefore assessed family members of individuals with OI type VI and compared the results of SERPINF1 mutation carriers with those of noncarriers of SERPINF1 mutations. SETTING: This study was conducted at a metabolic bone clinic of a pediatric orthopedic hospital. SUBJECTS: The study population comprised 29 family members (age range 8-89 y; 18 females, 11 males) of patients with a diagnosis of OI type VI. Eighteen individuals were heterozygous for SERPINF1 mutations, but the others did not carry a mutation. MAIN OUTCOME MEASURES: PEDF expression was assessed in skin fibroblasts from four heterozygous SERPINF1 mutation carriers. Skeletal characteristics and body composition were measured using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Serum samples were used to quantify markers of bone metabolism, lipid status, and PEDF. RESULTS: Carriers of heterozygous stop or frame shift mutations in SERPINF1 had low SERPINF1 transcript levels. Mean PEDF serum concentrations were significantly lower in the carrier group than in the noncarriers (P = .04). However, no group differences were found with regard to areal bone density at the lumbar spine and total body, volumetric bone density at the radius and tibia, body composition, lipid status, and markers of bone metabolism. CONCLUSION: Heterozygous SERPINF1 mutation carriers had no detectable abnormalities in fat and bone, despite decreased PEDF expression.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1210/jc.2014-2505

  10 / 251712 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 24606090
[Au] Autor:Paulson RJ; Collins MG; Yankov VI
[Ad] Address:Keck School of Medicine (R.J.P), University of Southern California, Los Angeles, California 90033; Ferring Pharmaceuticals (M.G.C, V.Y), Parsippany, New Jersey 07054.
[Ti] Title:Progesterone pharmacokinetics and pharmacodynamics with 3 dosages and 2 regimens of an effervescent micronized progesterone vaginal insert.
[So] Source:J Clin Endocrinol Metab;99(11):4241-9, 2014 Nov.
[Is] ISSN:1945-7197
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CONTEXT: Progesterone vaginal insert (PVI), an effervescent delivery system, dissolves rapidly, is absorbed through the vaginal epithelium, and achieves higher endometrial tissue concentrations than those achieved with progesterone in oil (PIO) given im. OBJECTIVE: Our objective was to examine the pharmacokinetics and pharmacodynamics of PVI compared with PIO. DESIGN, SETTING, AND PARTICIPANTS: Fifty-eight healthy premenopausal women were randomized to 50, 100, or 200 mg PVI once daily; 100 or 200 mg PVI twice daily; or 50 to 100 mg PIO via im injection once daily for 10 days. Serum samples were obtained after the first dose; serum and endometrial tissue were obtained after the last dose. MAIN OUTCOME MEASURES: Maximum observed serum concentration (Cmax), time to Cmax, and area under the serum-concentration time curve over the dosing interval were calculated after correcting for baseline progesterone concentrations. ANOVA and paired t test were used to compare results across and within groups. RESULTS: A higher Cmax was observed after PIO than PVI administration. Endometrial tissue progesterone concentrations were higher for PVI regimens. Time to Cmax was 7.3 hours after PIO and 3.3 to 5.9 hours after PVI. Steady state was achieved within 24 and 48 hours for PVI and PIO regimens, respectively. The area under the curve increased with increasing PVI dosage; however, the increase was not proportional to the increase in dosage. Downregulation of estrogen and progesterone receptors was observed in secretory biopsy specimens. CONCLUSION: The PVI system consistently allowed for rapid progesterone absorption and achieved higher endometrial tissue concentrations and lower systemic exposures than observed after im PIO.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1210/jc.2013-3937


page 1 of 25172 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information