Database : MEDLINE
Search on : erythema and multiforme [Words]
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[PMID]: 29516895
[Au] Autor:Gunawan H; Yogya Y; Hafinah R; Marsella R; Ermawaty D; Suwarsa O
[Ad] Address:Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
[Ti] Title:Reactive perforating leprosy, erythema multiforme-like reactions, sweet's syndrome-like reactions as atypical clinical manifestations of Type 2 leprosy reaction.
[So] Source:Int J Mycobacteriol;7(1):97-100, 2018 Jan-Mar.
[Is] ISSN:2212-554X
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Type 2 leprosy reactions commonly known as erythema nodosum leprosum, but various clinical manifestations of type 2 leprosy reaction were exist. The highlight of this case series was to report various atypical clinical manifestations of type 2 leprosy reaction such as reactive perforating leprosy, erythema multiforme-like reaction, and sweet's syndrome (SS)-like reaction.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.4103/ijmy.ijmy_186_17

  2 / 2857 MEDLINE  
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[PMID]: 28745229
[Au] Autor:Martins ICF; Raposo NRB; Mockdeci HR; Polonini HC; de Oliveira Ferreira A; Fabri GMC; das Gracas Afonso Miranda Chaves M
[Ad] Address:Faculty of Dentistry, Federal University of Juiz de Fora, 36036-900, Juiz de Fora, MG, Brazil.
[Ti] Title:Delivering Resveratrol on the Buccal Mucosa Using Mucoadhesive Tablets: A Potential Treatment Strategy for Inflammatory Oral Lesions.
[So] Source:Curr Drug Deliv;15(2):254-259, 2018 Feb 14.
[Is] ISSN:1875-5704
[Cp] Country of publication:United Arab Emirates
[La] Language:eng
[Ab] Abstract:BACKGROUND: Resveratrol is a polyphenol that has gained momentum in therapeutics in the last few years. OBJECTIVE: In this study, we hypothesised that resveratrol could act prophylactically and/or treat inflammatory lesions of the oral cavity after being delivered by two different formulations of buccal mucoadhesive tablets (F1 and F2, which differed in terms of viscosity agents used). METHODS: This hypothesis was assessed through permeation studies, to verify diffusion of the drug through the buccal mucosa using a porcine model to predict human in vivo behaviour. RESULTS: F2 (tablet with less viscosity agent) presented better permeation than F1, but the amount of drug that crossed the mucosa was still low compared to the amount retained within it (35.90 µg found in the receptor medium and 15.63 mg quantified within the mucosa). CONCLUSION: This accounted for a local effect rather than a systemic one, which is desirable for local processes, such as oral mucositis, lichen planus, erythema multiforme, nicotinic stomatitis, recurrent aphthous stomatitis, among others. In this sense, resveratrol-loaded mucoadhesive tablets appear to be a prominent alternative to prevent and/or cure inflammatory lesions of the oral cavity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Process
[do] DOI:10.2174/1567201814666170726102558

  3 / 2857 MEDLINE  
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[PMID]: 29483433
[Au] Autor:Takano J; Matsuhashi N; Takahashi T; Tanahashi T; Matsui S; Imai H; Tanaka Y; Yamaguchi K; Yoshida K
[Ad] Address:Dept. of Surgical Oncology, Gifu University.
[Ti] Title:[A Case of Metastatic Colorectal Cancer with Brain Metastasis Treated with Combined TFTD and Bevacizumab Therapy].
[So] Source:Gan To Kagaku Ryoho;45(2):318-320, 2018 Feb.
[Is] ISSN:0385-0684
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:A woman in her 70s was confirmed as presenting with multiple liver and lung metastases from transverse colon cancer. After undergoing resection of the primary lesion, partial response(PR)was achieved after undergoing the first regimen (sLV5FU2 and bevacizumab[Bmab]); therefore, partial hepatectomy was performed. Adjuvant chemotherapy was administered for 7 months, but liver metastasis recurrence, multiple lung metastases, and brain metastasis were confirmed. As the brain metastasis was a single lesion and was accompanied by symptoms, resection of the lesion was performed. Treatment with regorafenib was initiated, but Grade 3 severe erythema multiforme was detected, and the treatment had to be discontinued. Therefore, combined TFTD and Bmab therapy was initiated as the third regimen. Liver and lung metastases were maintained as stable disease(SD), and the treatment was continued for approximately 1 year together with stereotaxic radiation therapy for the newbrain metastatic lesion. The utility of combined TFTD and Bmab therapy has been reported in a phase II trial, and it has also been indicated that Bmab is effective for reducing brain edema. As this treatment was effective in this case, we will report on it together with a discussion of the literature.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Data-Review

  4 / 2857 MEDLINE  
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[PMID]: 29410254
[Au] Autor:Siripassorn K; Ruxrungtham K; Manosuthi W
[Ad] Address:Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand. Electronic address: krittaecho@yahoo.com.
[Ti] Title:Successful drug desensitization in patients with delayed-type allergic reactions to anti-tuberculosis drugs.
[So] Source:Int J Infect Dis;68:61-68, 2018 Feb 02.
[Is] ISSN:1878-3511
[Cp] Country of publication:Canada
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the outcomes of anti-tuberculosis drug desensitization. METHODS: This was a retrospective study. Inclusion criteria were as follows: age >18years, documented tuberculosis infection, a previous cutaneous allergic reaction to anti-tuberculosis drugs, and having undergone drug desensitization between January 2003 and March 2014. The definition of allergic reaction to anti-tuberculosis drugs included (1) a temporal relationship between drug use and the allergic reaction; (2) improvement in the allergic reaction after drug withdrawal; (3) recurrence of the allergic reaction after reintroduction of only the offending drug; and (4) absence of other causes. RESULTS: A total of 19 desensitization procedures were performed. The drugs used for these procedures were isoniazid (n=7), rifampicin (n=6), or ethambutol (n=6). Of note, severe allergic reactions (Stevens-Johnson syndrome (n=4), erythema multiforme (n=3), and drug rash with eosinophilia and systemic syndrome (n=1)) were included. All patients underwent resolution of the previous allergic reactions before desensitization. The median duration of desensitization was 18 days. The success rate was 78.9%. The allergic reactions following failed desensitization were not severe; most were maculopapular rashes. CONCLUSIONS: The desensitization protocol for anti-tuberculosis drugs was associated with a high success rate, and the individuals who failed desensitization experienced mild allergic reactions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher

  5 / 2857 MEDLINE  
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[PMID]: 29469784
[Au] Autor:Arnold M; Wilkerson M
[Ti] Title:A case of erythema multiforme major following administration of ciprofloxacin ophthalmic drops.
[So] Source:Dermatol Online J;23(10), 2017 Oct 15.
[Is] ISSN:1087-2108
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A 49-year old woman was hospitalized for generalized rash and pruritus following the administration of ophthalmic drops containing ciprofloxacin to treat conjunctivitis. Physical examination demonstrated diffuse erythematous papules and plaques with a targetoid appearance, injected sclera, and multiple erosions in the oropharynx. Skin biopsy confirmed a diagnosis of erythema multiforme major. The eye drops were discontinued and supportive treatment was initiated; the patient recovered in four weeks and was discharged from the hospital. Although cases such as this are rare, it is important that physicians take a thorough medication history from all patients with suspected erythema multiforme, including topical and ophthalmic medications. Prompt discontinuation of the offending agent can hasten patient recovery and optimize outcomes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process

  6 / 2857 MEDLINE  
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[PMID]: 29469759
[Au] Autor:Chahal D; Aleshin M; Turegano M; Chiu M; Worswick S
[Ad] Address:Division of Dermatology, University of California Los Angeles, Los Angeles, California. dchahal@mednet.ucla.edu.
[Ti] Title:Vaccine-induced toxic epidermal necrolysis: A case and systematic review.
[So] Source:Dermatol Online J;24(1), 2018 Jan 15.
[Is] ISSN:1087-2108
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are cutaneous hypersensitivityreactions that develop in response to specific triggers such as medications and certain infections. Vaccines, which undergo rigorous safety testing prior to use in humans, are a rare cause of SJS/TEN and little is known about the frequency of such events and corresponding pathogenesis. OBJECTIVE: Herein, we discuss a case of suspected TEN in a 19-year-old woman who received the meningococcal B vaccine (the first report of such an association) and conduct a systematic review of the associated literature. We also discuss management of this patient with a single dose of etanercept. METHODS: Relevant literature was searched using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. RESULTS: A total of 29 articles reporting EM, SJS, or TEN following vaccination were included from >5 countries. Of the 29, 22 articles reported EM, 6/29 reported SJS, and 4/29 reported TEN (3 articlesreported cases of both EM and SJS/TEN). CONCLUSIONS: We suggest consideration of vaccines as an etiology for cases of SJS or TEN that begin with an EM-like presentation, and provide further evidence for the use of etanercept as a viable treatment for TEN.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process

  7 / 2857 MEDLINE  
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[PMID]: 29469720
[Au] Autor:Sundaresan S; Nguyen KT; Nelson KC; Ivan D; Patel AB
[Ti] Title:Erythema multiforme major in a patient with metastatic melanoma treated with nivolumab.
[So] Source:Dermatol Online J;23(9), 2017 Sep 15.
[Is] ISSN:1087-2108
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Nivolumab, a relatively novel immune checkpoint inhibitor with FDA approval in 2014, is gaining greater utilization due to its efficacy in treating metastatic melanoma. Many of the cutaneous immune-related adverse events (irAEs) being catalogued do not necessitate discontinuation of immunotherapy and are managed with supportive therapy. We present a case of erythema multiforme major secondary to nivolumab requiring hospitalization and discontinuation of treatment. This is only the second reported case of nivolumab-induced erythema multiforme in the literature we are aware of, and emphasizes the importance of oncologists working in conjunction with dermatologists for prompt diagnosis and management.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process

  8 / 2857 MEDLINE  
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[PMID]: 29463113
[Au] Autor:Ashton R; Wong KW; Weinstein M
[Ad] Address:1 King's College London, St John's Institute of Dermatology, London, UK.
[Ti] Title:Pediatric Lip Adhesion Following Bullous Erythema Multiforme and Review of Similar Oral Complications.
[So] Source:J Cutan Med Surg;:1203475418761038, 2018 Feb 01.
[Is] ISSN:1615-7109
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Erythema multiforme (EM) is a mucocutaneous disease most often associated with preceding herpes simplex virus or Mycoplasma pneumoniae infection. It is characterized by targetoid lesions occurring on the limbs and head and neck. Mucosal involvement can be extensive. OBJECTIVE: We report a case of lip adhesion as a complication of EM in a child who required corrective surgery and review similar oral commissure complications. METHODS: We completed a review of the literature for similar cases using PubMed and Medline. CONCLUSIONS AND RELEVANCE: We present the youngest report of lip adhesion due to striking mucositis related to EM. Sequelae of erythema multiforme can be significant, in our case requiring surgery. Meticulous oral hygiene should be encouraged when mucosal lesions are identified.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:Publisher
[do] DOI:10.1177/1203475418761038

  9 / 2857 MEDLINE  
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[PMID]: 29363636
[Au] Autor:Taqi SA
[Ad] Address:Department of Oral and Maxillofacial Surgery Sciences, Division of Oral Pathology and Microbiology, Najran University College of Dentistry, Najran, Saudi Arabia.
[Ti] Title:Drug-induced oral erythema multiforme: A diagnostic challenge.
[So] Source:Ann Afr Med;17(1):43-45, 2018 Jan-Mar.
[Is] ISSN:0975-5764
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Trimethoprim-sulfamethoxazole (cotrimoxazole or TMP/SMX) is commonly used for the treatment of urinary or lower respiratory tract infections. A comprehensive review is presented of the world literature on adverse reactions to TMP/SMX since its first use in 1968, when concern was expressed about possible hematologic toxicity. The adverse reactions to TMP/SMX occur in approximately 1%-3% of persons in general population. Here, we report a case of oral erythema multiforme (EM) secondary to TMP/SMX that presented with oral and lip ulcerations typical of EM without any skin lesions and highlights the importance of distinguishing them from other ulcerative disorders involving oral cavity. The patient was treated symptomatically and given tablet prednisolone. The condition improved with stoppage of TMP/SMX therapy. It has been reported that primary attacks of oral EM is confined to the oral mucosa, but the subsequent attacks can produce more severe forms of EM involving the skin. Hence, it is important to identify for early diagnosis and management. Although EM is quite common with TMP/SMX, there are no reports of oral EM appearing after intake of this drug.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1801
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:In-Data-Review
[do] DOI:10.4103/aam.aam_19_17

  10 / 2857 MEDLINE  
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[PMID]: 29450445
[Au] Autor:Drahy F; Ingen-Housz-Oro S; Grootenboer-Mignot S; Wolkenstein P; Chosidow O
[Ad] Address:Department of Dermatology, Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, Créteil, France.
[Ti] Title:Lenalidomide as an Alternative to Thalidomide for Treatment of Recurrent Erythema Multiforme.
[So] Source:JAMA Dermatol;, 2018 Feb 14.
[Is] ISSN:2168-6084
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:Publisher
[do] DOI:10.1001/jamadermatol.2017.5889


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