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[PMID]: 29524782
[Au] Autor:Nagasaka H; Hirano KI; Yorifuji T; Komatsu H; Takatani T; Morioka I; Hirayama S; Miida T
[Ad] Address:Department of Pediatrics, Takarazuka City Hospital, Takarazuka, Japan. Electronic address: Nagasaka@cnt-osaka.com.
[Ti] Title:Treatment with medium chain fatty acids milk of CD36-deficient preschool children.
[So] Source:Nutrition;50:45-48, 2017 Nov 29.
[Is] ISSN:1873-1244
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: CD36 deficiency is characterized by limited cellular long chain fatty acid uptake in the skeletal and cardiac muscles and often causes energy crisis in these muscles. However, suitable treatment for CD36 deficiency remains to be established. The aim of this study was to evaluate the clinical and metabolic effects of medium chain triacylglycerols (MCTs) in two CD36-deficient preschool children who often developed fasting hypoglycemia and exercise-induced myalgia. METHODS: Fasting blood glucose, total ketone bodies, and free fatty acids were examined and compared for usual supper diets and for diets with replacement of one component with 2 g/kg of 9% MCT-containing milk (MCT milk). Changes in serum creatine kinase and alanine aminotransferase levels, resulting from replacement of glucose water intake with 1 g/kg of MCT milk and determined by using bicycle pedaling tasks, were examined and compared. Hypoglycemic and/or myalgia episodes in daily life were also investigated. RESULTS: Biochemically, participants' blood glucose and total ketone bodies levels after overnight fasting substantially increased after dietary suppers containing MCT milk. Increases in serum creatine kinase and alanine aminotransferase levels resulting from the bicycle pedaling task were suppressed by MCT milk. Hypoglycemia leading to unconsciousness and tachycardia before breakfast decreased after introduction of dietary suppers containing MCT milk. Occurrence of myalgia in the lower limbs also decreased after intakes of MCT milk before long and/or strenuous exercising. CONCLUSION: Our results suggest that MCTs can prevent fasting hypoglycemia and exercise-induced myalgia in CD36-deficient young children.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524751
[Au] Autor:Yu W; Singh SS; Calhoun S; Zhang H; Zhao X; Yang F
[Ad] Address:School of Health Management and Education, Capital Medical University, Beijing, China; Medical Affairs, Pfizer Investment Co., Ltd, Beijing, China.
[Ti] Title:Generalized anxiety disorder in urban China: Prevalence, awareness, and disease burden.
[So] Source:J Affect Disord;234:89-96, 2018 Feb 21.
[Is] ISSN:1573-2517
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Limited published research has quantified the Generalized Anxiety Disorder (GAD) prevalence and its burden in China. This study aimed to fill in the knowledge gap and to evaluate the burden of GAD among adults in urban China. METHODS: This study utilized existing data from the China National Health and Wellness Survey (NHWS) 2012-2013. Prevalence of self-reported diagnosed and undiagnosed GAD was estimated. Diagnosed and undiagnosed GAD respondents were compared with non-anxious respondents in terms of health-related quality of life (HRQoL), resource utilization, and work productivity and activity impairment using multivariate generalized linear models. A multivariate logistic model assessed the risk factors for GAD. RESULTS: The prevalence of undiagnosed/diagnosed GAD was 5.3% in urban China with only 0.5% of GAD respondents reporting a diagnosis. Compared with non-anxious respondents, both diagnosed and undiagnosed GAD respondents had significantly lower HRQoL, more work productivity and activity impairment, and greater healthcare resource utilization in the past six months. Age, gender, marital status, income level, insurance status, smoking, drinking and exercise behaviors, and comorbidity burdens were significantly associated with GAD. LIMITATIONS: This was a patient-reported study; data are therefore subject to recall bias. The survey was limited to respondents in urban China; therefore, these results focused on urban China and may be under- or over-estimating GAD prevalence in China. Causal inferences cannot be made given the cross-sectional nature of the study. CONCLUSIONS: GAD may be substantially under-diagnosed in urban China. More healthcare resources should be invested to alleviate the burden of GAD.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524725
[Au] Autor:Vaughan MH; Kim-Fine S; Hullfish KL; Smith TM; Siddiqui NY; Trowbridge ER
[Ad] Address:Department of Obstetrics & Gynecology, Division of Urogynecology and Reconstructive Pelvic Surgery, Duke University Medical Center, Durham, NC. Electronic address: monique.vaughan@duke.edu.
[Ti] Title:Validation of the Simulated Vaginal Hysterectomy Trainer (Simvaht).
[So] Source:J Minim Invasive Gynecol;, 2018 Mar 07.
[Is] ISSN:1553-4669
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:STUDY OBJECTIVE: To establish construct validity of the simulated vaginal hysterectomy trainer (SimVaHT). DESIGN: Cross-sectional validation study (Canadian Task Force classification II-2). SETTING: Single academic medical center in the United States. SUBJECTS: Fourteen residents in Obstetrics and Gynecology (four PGY-1, four PGY-2, three PGY-3 and three PGY-4). PGY-1 and PGY-2 residents were grouped to form the "junior level" cohort, while PGY-3 and PGY-4 residents comprised the "senior level" cohort. INTERVENTIONS: Each participant underwent surgical skill simulation by performing a simulated vaginal hysterectomy on a practical, inexpensive vaginal hysterectomy trainer. MEASUREMENTS AND MAIN RESULTS: The primary outcome was resident surgical skill as assessed by the Objective Structured Assessment of Technical Skills Global Rating Scale (GRS). All Obstetrics and Gynecology residents were videotaped performing a simulated vaginal hysterectomy on the SimVaHT. The tapes were reviewed independently by two blinded urogynecology experts, each of whom provided a GRS score. The primary outcome was overall GRS scores. Secondary outcome was time to complete the exercise. GRS scores were compared between junior and senior level residents. Senior level residents scored significantly higher on the GRS overall compared to junior level residents (p=0.008). CONCLUSION: Construct validity was demonstrated for the simulated vaginal hysterectomy trainer (SimVaHT). The SimVaHT is a practical and inexpensive tool that may improve resident vaginal surgical skills prior to their first case in the operating room.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524603
[Au] Autor:Shieh HF; Smithers CJ; Hamilton TE; Zurakowski D; Visner GA; Manfredi MA; Jennings RW; Baird CW
[Ad] Address:Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
[Ti] Title:Descending Aortopexy and Posterior Tracheopexy for Severe Tracheomalacia and Left Mainstem Bronchomalacia.
[So] Source:Semin Thorac Cardiovasc Surg;, 2018 Mar 07.
[Is] ISSN:1532-9488
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Posterior descending aortopexy can relieve posterior intrusion of the left mainstem bronchus that may limit the effectiveness of posterior tracheobronchopexy. We review outcomes of patients undergoing both descending aortopexy and posterior tracheopexy for severe tracheobronchomalacia with posterior intrusion and left mainstem compression to determine if there were resolution of clinical symptoms and bronchoscopic evidence of improvement in airway collapse. METHODS: All patients who underwent both descending aortopexy and posterior tracheopexy from October 2012 to October 2016 were retrospectively reviewed. Clinical symptoms, tracheomalacia scores based on standardized dynamic airway evaluation by anatomical region, and persistent airway intrusion requiring reoperation were collected. Data were analyzed by Wald and Wilcoxon signed-ranks tests. RESULTS: 32 patients underwent descending aortopexy and posterior tracheopexy at median age 18 months (IQR 6-40 months). Median follow up was 3 months (IQR 1-7 months). There were statistically significant improvements in clinical symptoms postoperatively, including cough, noisy breathing, prolonged and recurrent respiratory infections, ventilator dependence, blue spells, and brief resolved unexplained events (BRUEs) (all P<.001), as well as exercise intolerance (P=.033), transient respiratory distress requiring positive pressure (P=.003), and oxygen dependence (P=.007). Total tracheomalacia scores improved significantly (P<.001), with significant segmental improvements in the middle (P=.003) and lower (P<.001) trachea, and right (P=.011) and left (P<.001) mainstem bronchi. 2 patients (6%) had persistent airway intrusion requiring reoperation with anterior aortopexy and/or tracheopexy. CONCLUSIONS: Descending aortopexy and posterior tracheopexy are effective in treating severe tracheobronchomalacia and left mainstem intrusion with significant improvements in clinical symptoms and degree of airway collapse on bronchoscopy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524588
[Au] Autor:Taran S; Conti J; Routhier F; Latimer-Cheung AE; Noreau L; Sweet SN
[Ad] Address:McGill University, Faculty of Education, Department of Kinesiology and Physical Education, 475 Av. Des Pins O., H2S 1S4, Montreal, Quebec, Canada; Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), 2275 Laurier Ave., H2H 2N8, Montreal, Quebec. Electronic address: sam
[Ti] Title:Leisure time physical activity, perception of impact of pain and life satisfaction after spinal cord injury.
[So] Source:Ann Phys Rehabil Med;, 2018 Mar 07.
[Is] ISSN:1877-0665
[Cp] Country of publication:Netherlands
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  6 / 306401 MEDLINE  
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[PMID]: 29524552
[Au] Autor:Doughty AK; Horton BJ; Huyen NTD; Ballagh CR; Corkrey R; Hinch GN
[Ad] Address:University of New England, Armidale, NSW, 2350, Australia; CRC for Sheep Industry Innovation, Armidale, NSW, 2350, Australia. Electronic address: amanda.doughty@une.edu.au.
[Ti] Title:The influence of lameness and individuality on movement patterns in sheep.
[So] Source:Behav Processes;, 2018 Mar 07.
[Is] ISSN:1872-8308
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:We investigated how individuality and lameness altered social organisation by assessing food-directed movement patterns in sheep. One hundred and ninety-six mature Merino ewes were walked in 16 different runs around a 1.1 km track following a food source. Flock position and lameness, were measured and temperament was assessed using an Isolation Box Test. The mean value for the correlations of position between a run and the run preceding it was r = 0.55 ± SEM 0.03. All correlations between runs were positive (r = 0.08 - 0.76) and all but two were statistically significant (P < 0.05). The weakest and least statistically significant correlations were for run 14; where all 16 runs were conducted 3 to 4 times a week, except with an interval of 20 weeks between runs 13 and 14. Additionally, there were differences in overall positions for a lame versus a non-lame individual (all P < 0.05) with lame sheep being further back in position when compared to their non-lame mean positions. These results indicate the movement patterns, as measured by flock position during a food-directed forced movement exercise, are relatively stable provided tests occur frequently, possibly on a bi-weekly basis. However, further work would be required to better account for individual animal variation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  7 / 306401 MEDLINE  
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[PMID]: 29524513
[Au] Autor:Siteneski A; Cunha MP; Lieberknecht V; Pazini FL; Gruhn K; Brocardo PS; Rodrigues ALS
[Ad] Address:Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
[Ti] Title:Central irisin administration affords antidepressant-like effect and modulates neuroplasticity-related genes in the hippocampus and prefrontal cortex of mice.
[So] Source:Prog Neuropsychopharmacol Biol Psychiatry;, 2018 Mar 07.
[Is] ISSN:1878-4216
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Evidence has indicated that the practice of physical exercise has antidepressant effects that might be associated with irisin release and BDNF signaling. In this study we investigated the effects of the central administration of irisin or BDNF in predictive tests of antidepressant properties paralleled with the gene expression of peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1-α), fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF) in the hippocampus and prefrontal cortex of mice. Irisin (0.5-1 ng/mouse, i.c.v.) reduced the immobility time in the tail suspension test (TST) and forced swim test (FST), without altering locomotion in the open field test (OFT). Irisin reduced the immobility time in the TST up to 6 h after its administration. Irisin administration (6 h) increased PGC1-α mRNA in the hippocampus and prefrontal cortex and reduced (1 h) PGC1-α mRNA in the prefrontal cortex. FNDC5 and BDNF mRNA expression was decreased (1 h) in both structures and remained reduced up to 6 h in the prefrontal cortex. Moreover, BDNF administered at 0.25 µg/mouse, i.c.v. (1 and 6 h before the test) reduced the immobility time in the TST. BDNF administration reduced PGC1-α mRNA in the hippocampus (6 h) and prefrontal cortex (1 and 6 h). It also increased FNDC5 mRNA expression in the hippocampus (1 and 6 h), but reduced the expression of this gene and also BDNF mRNA in the prefrontal cortex (1 and 6 h). None of the treatments altered BDNF protein levels in both structures. In conclusion, irisin presents a behavioral antidepressant profile similar to BDNF, an effect associated with the modulation of gene expression of PGC1-α, FNDC5 and BDNF, reinforcing the pivotal role of these genes in mood regulation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524447
[Au] Autor:Da-Silva F; Boulenc X; Vermet H; Compigne P; Gerbal-Chaloin S; Daujat-Chavanieu M; Klieber S; Poulin P
[Ad] Address:Sanofi R&D, Montpellier, France; Institute for Regenerative Medicine and Biotherapy, Université et CHU de Montpellier, INSERM, Montpellier, France.
[Ti] Title:Improving Prediction Of Metabolic Clearance Using Quantitative Extrapolation Of Results Obtained From Human Hepatic Mpcc Model And By Considering The Impact Of Albumin Binding.
[So] Source:J Pharm Sci;, 2018 Mar 07.
[Is] ISSN:1520-6017
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The objective was to compare, with the same dataset, the predictive performance of three in vitro assays of hepatic clearance (CL), namely, micropatterned cocultures (MPCC) (also referring to HepatoPac ) and suspension as well as monolayer hepatocytes to define which assay is the most accurate. Furthermore, existing in vitro-to-in vivo extrapolation (IVIVE) methods were challenged to verify which method is the most predictive (i.e., direct scaling method without binding correction, conventional method based either on the unbound fraction in plasma (fu ) according to the free drug hypothesis, or based on an fu value adjusted for the albumin (ALB)-facilitated hepatic uptake phenomenon). Accordingly, the role of ALB binding was specifically challenged, and, consequently, the ALB production was monitored in parallel to the metabolic stability. The ALB concentration data were used to compare the in vitro assays and to adjust the value of fu of each drug to mimic the ALB-facilitated hepatic uptake phenomenon. The results confirmed that the direct and conventional IVIVE methods generally over- and under-predicted the CL in vivo in humans, respectively. However, the under-prediction of the conventional IVIVE method based on fu was significantly reduced from data generated with the HepatoPac® system compared to the two other in vitro assays, which is possibly because that system is producing ALB at a rate much closer to the in vivo condition in liver. Hence, these observations suggest that the presence of more ALB molecules per hepatocyte in that Hepatopac® system may have facilitated the hepatic uptake of several bound drugs because their intrinsic CL was increased instead of being decreased by the ALB binding effect. Accordingly, the IVIVE method based on the fu value adjusted for the ALB-facilitated uptake phenomenon gave the lowest prediction bias from the statistical analyses. This study indicated that the HepatoPac® system combined with the adjusted value of fu was the most reliable IVIVE method, and revealed the importance of quantifying the in vitro-to-in vivo variation of ALB concentration to improve the CL predictions, which would help any future physiologically-based pharmacokinetics (PBPK) modelling exercise.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  9 / 306401 MEDLINE  
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[PMID]: 29524398
[Au] Autor:Medrinal C; Prieur G; Combret Y; Quesada AR; Debeaumont D; Bonnevie T; Gravier FE; Dupuis Lozeron E; Quieffin J; Contal O; Lamia B
[Ad] Address:Normandie Univ, UNIROUEN, EA3830 - GRHV, 76000 Rouen, France; Institute for Research and Innovation in Biomedicine (IRIB), 76000 Rouen, France; Pulmonology Department, avenue Pierre Mendes France 76290 Montivilliers, France. Electronic address: medrinal.clement.mk@gmail.com.
[Ti] Title:Functional Electrical Stimulation-A new therapeutic approach to enhance exercise intensity in Chronic Obstructive Pulmonary Disease patients : a randomised controlled cross-over trial.
[So] Source:Arch Phys Med Rehabil;, 2018 Mar 07.
[Is] ISSN:1532-821X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the effect of quadriceps Functional Electrical Stimulation (FES)-Cycling on exertional VO compared with Placebo FES-cycling in patients with COPD. DESIGN: A randomised, single-blind, placebo-controlled, cross-over trial SETTING: Pulmonary Rehabilitation Department PARTICIPANTS: 23 consecutive patients with COPD GOLD stage 2, 3 or 4 (mean FEV1 : 1.4±0.4 L (50.3% pred)) who had recently begun a respiratory rehabilitation program. INTERVENTION: Two consecutive 30-minute sessions were carried out at a constant load with active and placebo FES-Cycling. MAIN OUTCOME MEASURES: The primary outcome was mean VO during the 30-minute exercise session. The secondary outcomes were respiratory gas exchange and hemodynamic parameters averaged over the 30-minute endurance session. Lactate values, dyspnea and perceived muscle fatigue were evaluated at the end of the sessions. RESULTS: FES-Cycling increased the physiological response more than the placebo, with a greater VO achieved of 36.6 (95% CI 8.9-64.3) mL/min (p=0.01). There was also a greater increase in lactate after FES-Cycling (+1.5 (95% CI 0.05 to 2.9) mmol/L; p=0.01). FES-Cycling did not change dyspnoea or muscle fatigue compared with the placebo condition. CONCLUSION: FES-Cycling effectively increased exercise intensity in patients with COPD. Further studies should evaluate longer-term FES-Cycling rehabilitation programs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  10 / 306401 MEDLINE  
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[PMID]: 29524397
[Au] Autor:Engel L; Chui A; Beaton DE; Green RE; Dawson DR
[Ad] Address:Rehabilitation Sciences Institute, University of Toronto, Suite 160 - 500 University Avenue, Toronto, Ontario, Canada, M5G 1V7; Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, Ontario, Canada, M6A 2E1. Electronic address: lisa.engel@mail.utoronto.ca.
[Ti] Title:Systematic review of measurement property evidence for eight financial management instruments in populations with acquired cognitive impairment.
[So] Source:Arch Phys Med Rehabil;, 2018 Mar 07.
[Is] ISSN:1532-821X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To critically appraise the measurement property evidence (i.e., psychometric) for eight observation-based financial management assessment instruments. DATA SOURCES: Seven databases were searched in May 2015. STUDY SELECTION: Two reviewers used an independent decision-agreement process to select studies of measurement property evidence relevant to populations with adulthood acquired cognitive impairment, appraise the quality of the evidence, and extract data. Twenty-one articles were selected. DATA EXTRACTION: This review used the COnsensus-based Standards for the selection of health Measurement Instruments review (COSMIN) guidelines and four-point tool to appraise evidence. After appraising the methodological quality, adequacy of results and volume of evidence per instrument were synthesized. Measurement property evidence with high risk of bias was excluded from the synthesis. DATA SYNTHESIS: Volume of measurement property evidence per instrument is low; most instruments had one to three included studies. Many included studies had poor methodological quality per measurement property evidence area examined. Six of the eight instruments reviewed had supporting construct validity/hypothesis-testing evidence of fair methodological quality. There is a dearth of acceptable quality content validity, reliability, and responsiveness evidence for all eight instruments. CONCLUSIONS: Rehabilitation practitioners assess financial management functions in adults with acquired cognitive impairments. However, there is limited published evidence to support using any of the reviewed instruments. Practitioners should exercise caution when interpreting results of these instruments. This review highlights the importance of appraising the quality of measurement property evidence prior to examining the adequacy of the results and synthesizing the evidence.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher


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