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[PMID]: 22441504
[Au] Autor:Rodrigues A; Araújo C; Carvalho R; Melo MA; Pinto L; da Graça LM
[Ad] Address:Department of Obstetrics, Gynecology and Reproductive Medicine, Hospital de Santa Maria, Lisbon, Portugal. andreia.dalmeida@gmail.com
[Ti] Title:Limb constriction secondary to pseudoamniotic band syndrome after selective fetoscopic laser surgery: report of a case with a favorable outcome.
[So] Source:Fetal Diagn Ther;32(4):288-91, 2012.
[Is] ISSN:1421-9964
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Pseudoamniotic band syndrome (PABS) is an iatrogenic complication that causes entanglement of fetal parts in a constrictive sheet of detached or ruptured amniotic membrane after an invasive procedure, namely amniocentesis, amnioreduction or septostomy in twins. The incidence and risk factors for PABS after fetoscopy-guided laser have not been documented [Winer et al.: Am J Obstet Gynecol 2008;198:393.e1-393.e5]. We report a case of monochorionic biamniotic twin pregnancy submitted to selective fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome at 16 weeks of gestation. The procedure was complicated by the death of one of the fetuses at 24 weeks of gestation. Moreover, the surviving twin was diagnosed postnatally with pseudoamniotic band syndrome, presenting with affected limbs. The newborn was submitted to surgical correction of these lesions with a successful outcome and was discharged on day 15.
[Mh] MeSH terms primary: Amniotic Band Syndrome/etiology
Fetofetal Transfusion/surgery
Limb Deformities, Congenital/etiology
Pregnancy, Twin
[Mh] MeSH terms secundary: Adult
Amniotic Band Syndrome/physiopathology
Cesarean Section
Constriction
Female
Fetal Death
Fetofetal Transfusion/embryology
Fetofetal Transfusion/ultrasonography
Fetoscopy/adverse effects
Humans
Infant, Newborn
Laser Therapy/adverse effects
Light Coagulation/adverse effects
Limb Deformities, Congenital/physiopathology
Limb Deformities, Congenital/surgery
Male
Pregnancy
Term Birth
Treatment Outcome
Ultrasonography, Prenatal
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1305
[Js] Journal subset:IM
[Da] Date of entry for processing:121211
[St] Status:MEDLINE
[do] DOI:10.1159/000336666

  2 / 1407 MEDLINE  
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[PMID]: 23141178
[Au] Autor:Liu XX; Lau Tk; Wang HF; Wong Sm; Leung Ty
[Ad] Address:Department of Ultrasound, First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
[Ti] Title:[Fetoscopic guided laser occlusion for twin-to-twin transfusion syndrome in 33 cases].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;47(8):587-91, 2012 Aug.
[Is] ISSN:0529-567X
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To evaluate the clinical effect of fetoscopic laser occlusion of chorioangiopagous vessels (FLOC) for monochorionic diamniotic twins (MCDA) pregnancies complicated with twin-to-twin transfusion syndrome(TTTS). METHODS: The clinical data of 33 consecutive cases of TTTS from Mainland China, who had FLOC in the Department of Obstetrics and Gynaecology of Prince of Wales Hospital (The Chinese University of Hong Kong) from November 2003 to December 2010, were reviewed and analyzed for peri-operative complications, perinatal outcomes and fetal survival rate. Clinical stage of TTTS was according to the Quintero staging system. RESULTS: (1) Pregnancy characteristics: the mean maternal age was 30; the median gestational age at FLOC was 23(+4) weeks; according to the Quintero staging system, 3 cases were Quintero staging I, 14 cases were Quintero staging II, 7 cases were Quintero staging III and 9 cases were Quintero staging IV. For the 3 stage I cases, FLOC was performed for severe maternal symptoms of polyhyramnios or severe fetal cardiac dysfunction. (2) Complications: intraoperative complications occurred in 5 patients including four uterine bleedings at the puncture site, one placental vascular anastomosis bleeding. Postoperative complications occurred in 6 patients including 2 abortions and 1 intrauterine death within one week after operation, 2 abortions and 1 amniotic band syndrome occurred from two to four weeks after operation. (3) Perinatal outcome and fetal survival rate: the median interval of 33 patients between FLOC and delivery was 9(+4) weeks; the median gestational age at delivery was 31(+6) weeks; the gestation at delivery was less than 24 weeks in 6% (2/33), 24 to 28 weeks in 21% (7/33), 28 to 32 weeks in 18% (6/33), 32 to 37 weeks in 55% (18/33). The mean birth weight of the donor was 1600 g (350 - 2520 g); the mean birth weight of the recipiert was 1930 g (400 - 3040 g). The overall survival rate, the double infant survival rate, the single survival rate and survival rate for at least one twin was 59% (39/66), 52% (17/33), 15% (5/33) and 67% (22/33), respectively. The overall survival rate dropped from 61% (17/28) in Quintero staging II to 9/18 in Quintero staging IV. CONCLUSIONS: FLOC for MCDA complicated with TTTS is associated with an overall survival of about 60%. Major complications are rare. The outcome is not only related to Quintero staging but also the close monitoring and timely termination of pregnancy.
[Mh] MeSH terms primary: Fetofetal Transfusion/surgery
Fetoscopy
Laser Coagulation/methods
Twins, Monozygotic
[Mh] MeSH terms secundary: Adult
Female
Fetofetal Transfusion/mortality
Fetofetal Transfusion/pathology
Gestational Age
Humans
Intraoperative Complications/epidemiology
Middle Aged
Postoperative Complications/epidemiology
Pregnancy
Pregnancy Complications/mortality
Pregnancy Complications/pathology
Pregnancy Complications/surgery
Pregnancy Outcome
Pregnancy Trimester, Second
Pregnancy, Twin
Retrospective Studies
Severity of Illness Index
Survival Rate
Treatment Outcome
Young Adult
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1305
[Js] Journal subset:IM
[Da] Date of entry for processing:121112
[St] Status:MEDLINE

  3 / 1407 MEDLINE  
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[PMID]: 23055333
[Au] Autor:Carreras E; Arévalo S; Bello-Muñoz JC; Goya M; Rodó C; Sanchez-Duran MA; Peiro JL; Cabero L
[Ad] Address:Maternal-Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain. ecarreras@vhebron.net
[Ti] Title:Arabin cervical pessary to prevent preterm birth in severe twin-to-twin transfusion syndrome treated by laser surgery.
[So] Source:Prenat Diagn;32(12):1181-5, 2012 Dec.
[Is] ISSN:1097-0223
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To describe the outcome of patients with twin-to-twin transfusion syndrome and cervical length ≤ 25 mm, treated with laser and an Arabin cervical pessary. METHODS: Retrospective analysis of a consecutive series of all cases with severe twin-to-twin transfusion syndrome who underwent laser surgery: a group with cervical length above 25 mm (group A) and two groups who had a cervical length of 25 mm or less prior to the procedure. The first 8 cases (group B) were managed expectantly and the next 8 cases had a cervical pessary inserted immediately after laser surgery (group C). Gestational age at birth was the primary outcome. The secondary outcome was a composite one encompassing severe neonatal morbidity. RESULTS: The median gestational age at laser surgery was 20 weeks in all groups but the median gestational age at delivery was significantly higher in group C versus B (28 vs 32 weeks, p = 0.01). Severe neonatal morbidity was present in 18% in group C and 70% in group B (p < 0.01). CONCLUSION: Early results suggest a potential role for pessary use in prolonging gestation in cases with shortened cervix at the time of laser. A randomized trial to test this hypothesis should be performed.
[Mh] MeSH terms primary: Fetofetal Transfusion/surgery
Laser Therapy/methods
Pessaries
Premature Birth/prevention & control
[Mh] MeSH terms secundary: Adult
Cervix Uteri/surgery
Female
Fetofetal Transfusion/epidemiology
Fetoscopy/adverse effects
Fetoscopy/methods
Fetoscopy/statistics & numerical data
Humans
Infant, Newborn
Laser Therapy/adverse effects
Laser Therapy/statistics & numerical data
Pessaries/utilization
Pregnancy
Pregnancy Outcome/epidemiology
Premature Birth/epidemiology
Premature Birth/etiology
Premature Birth/surgery
Retrospective Studies
Severity of Illness Index
[Pt] Publication type:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Entry month:1304
[Js] Journal subset:IM
[Da] Date of entry for processing:121123
[St] Status:MEDLINE
[do] DOI:10.1002/pd.3982

  4 / 1407 MEDLINE  
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[PMID]: 22990987
[Au] Autor:Ruano R; da Silva MM; Salustiano EM; Kilby MD; Tannuri U; Zugaib M
[Ad] Address:Department of Obstetrics and Gynecology; Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. rodrigoruano@usp.br
[Ti] Title:Percutaneous laser ablation under ultrasound guidance for fetal hyperechogenic microcystic lung lesions with hydrops: a single center cohort and a literature review.
[So] Source:Prenat Diagn;32(12):1127-32, 2012 Dec.
[Is] ISSN:1097-0223
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the perinatal outcomes in hydropic fetuses with congenital microcystic pulmonary lesions that underwent percutaneous, invasive, laser therapy. METHOD: This retrospective study reviews the literature and our experience between 2004 and 2010. Characteristics of the cystic lung lesions, liquor volume (presence of polyhydramnios or not), localization of ablation (vascular vs interstitial) and gestational age at which the procedure was performed were related to outcome (survival). RESULTS: In total, 16 fetuses with congenital lung lesions underwent 'invasive' percutaneous laser ablation, seven performed in our center and nine published cases. Survival rate was higher in fetuses with a subsequent postnatal diagnosis of bronchopulmonary sequestration (87.5%) compared with congenital adenomatoid malformation (28.6%; p = 0.04). The technique of vascular ablation was more successful (100%) than interstitial ablation (25.0%, p < 0.01). CONCLUSION: Percutaneous vascular laser ablation seems to be effective for bronchopulmonary sequestration in hydropic fetuses. Outcomes were worst following interstitial ablation for microcystic congenital adenomatoid with hydrops.
[Mh] MeSH terms primary: Cystic Adenomatoid Malformation of Lung, Congenital/surgery
Hydrops Fetalis/surgery
Laser Therapy/methods
Ultrasonography, Interventional/methods
Ultrasonography, Prenatal/methods
[Mh] MeSH terms secundary: Adult
Bronchopulmonary Sequestration/surgery
Bronchopulmonary Sequestration/ultrasonography
Cohort Studies
Cystic Adenomatoid Malformation of Lung, Congenital/ultrasonography
Female
Fetoscopy/methods
Humans
Hydrops Fetalis/ultrasonography
Infant, Newborn
Models, Biological
Pregnancy
Retrospective Studies
[Pt] Publication type:EVALUATION STUDIES; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1304
[Js] Journal subset:IM
[Da] Date of entry for processing:121123
[St] Status:MEDLINE
[do] DOI:10.1002/pd.3969

  5 / 1407 MEDLINE  
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[PMID]: 22631591
[Au] Autor:Sosa-Sosa C; Bermúdez C; Chmait RH; Kontopoulos E; Córdoba Y; Guevara-Zuloaga F; Steffensen T; Quintero RA
[Ad] Address:Instituto Venezolano de Investigaciones Científicas (IVIC), Altos de Pipe, Estado Miranda, Venezuela.
[Ti] Title:Intraluminal tracheal occlusion using a modified 8-mm Z-stent in a sheep model of left-sided congenital diaphragmatic hernia.
[So] Source:J Matern Fetal Neonatal Med;25(11):2346-53, 2012 Nov.
[Is] ISSN:1476-4954
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate pulmonary growth and development after fetoscopic intraluminal tracheal occlusion (FITO) using a modified 8-mm Z-stent in an ovine model of congenital left-sided diaphragmatic hernia (CDH). METHODS: Thirty-three time-dated ewes were studied: Group I: healthy controls; Group II: CDH controls (untreated); Group III: CDH treated with FITO. CDH was created in Groups II and III at 70-80 days' gestation. FITO was performed at 100-110 days. Left lung histological, morphometric, immunohistochemical and biochemical studies were conducted after delivery and euthanasia at 138 days. RESULTS: Fifteen (45%) animals (Group I: 3; Group II: 5; Group III: 7) were available for analysis. The left lung parenchymal volume to fetal weight ratios were similar between Groups I and III (p = 0.24), and higher than Group II (p < 0.05III (79 versus 75%, p = 0.26), compared to 41% in Group II (p < 0.05). Pulmonary hypoplasia occurred in 1/7 (16%) in the FITO group, compared to 100% in Group II and 0% in Group I (p = .003). DNA and protein were significantly increased in Group III (p < 0.001). The concentration of type II pneumocytes was similar between healthy controls and the FITO group, and was paradoxically increased in untreated hernia fetuses. There was no histological evidence of tracheal injury. CONCLUSION: FITO with a modified 8-mm Z-stent is associated with lung growth and maturation similar to controls without obvious deleterious effects. A phase I clinical trial of FITO with the modified 8-mm Z-stent in severe CDH patients seems warranted.
[Mh] MeSH terms primary: Fetoscopy/methods
Hernia, Diaphragmatic/congenital
Stents
Therapeutic Occlusion/methods
Trachea/surgery
[Mh] MeSH terms secundary: Animals
Disease Models, Animal
Female
Fetal Organ Maturity/physiology
Fetoscopy/veterinary
Functional Laterality
Gestational Age
Hernia, Diaphragmatic/pathology
Hernia, Diaphragmatic/surgery
Lung/cytology
Lung/embryology
Lung/pathology
Pregnancy
Sheep, Domestic
Trachea/pathology
[Pt] Publication type:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1304
[Js] Journal subset:IM
[Da] Date of entry for processing:121015
[St] Status:MEDLINE
[do] DOI:10.3109/14767058.2012.695825

  6 / 1407 MEDLINE  
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[PMID]: 22631227
[Au] Autor:Quintero RA; Kontopoulos E; Reiter J; Pedreira WL; Colin AA
[Ad] Address:Division of Fetal Therapy, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. rquintero@med.miami.edu
[Ti] Title:Fetal bronchoscopy: its successful use in a case of extralobar pulmonary sequestration.
[So] Source:J Matern Fetal Neonatal Med;25(11):2354-8, 2012 Nov.
[Is] ISSN:1476-4954
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To report the performance of fetal bronchoscopy in a case of pulmonary sequestration. MATERIALS AND METHODS: A 24 year-old female, Gravida 2, Para 1, was referred at 27.5 weeks with a large fetal left lung mass with marked right mediastinal shift and no visible normal left lung. Differential diagnosis included possible bronchial atresia. RESULTS: The patient underwent fetal laryngoscopy and fetal bronchoscopy at 31.5 weeks. The right lung and a portion of the left lung expanded during surgery as a result of bronchial lavage. Bronchial atresia or bronchogenic cyst were not found. Pregnancy continued uneventfully, with continuous growth of the right lung and a small amount of left lung. The patient delivered vaginally at term. The baby underwent thoracoscopic resection of a pulmonary sequestration at 10.5 months of age and did well. CONCLUSION: Fetal bronchoscopy is feasible. The procedure may prove useful in the differential diagnosis and in the potential treatment of different fetal lung lesions, as well as aid in the understanding of the role of bronchial obstruction as a common pathophysiologic mechanism for different fetal lung masses. Risks and benefits of fetal bronchoscopy warrant further experience.
[Mh] MeSH terms primary: Bronchopulmonary Sequestration/therapy
Bronchoscopy/methods
Fetal Diseases/surgery
Fetoscopy/methods
[Mh] MeSH terms secundary: Bronchopulmonary Sequestration/diagnosis
Diagnosis, Differential
Female
Fetal Diseases/diagnosis
Fetus/surgery
Humans
Pregnancy
Treatment Outcome
Young Adult
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1304
[Js] Journal subset:IM
[Da] Date of entry for processing:121015
[St] Status:MEDLINE
[do] DOI:10.3109/14767058.2012.695826

  7 / 1407 MEDLINE  
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[PMID]: 23201086
[Au] Autor:Kuller JA; Norton ME
[Ti] Title:Expanding the gestational age limits for laser treatment for twin-twin transfusion.
[So] Source:Am J Obstet Gynecol;208(3):165-6, 2013 Mar.
[Is] ISSN:1097-6868
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Fetofetal Transfusion/surgery
Fetoscopy/methods
Laser Therapy/methods
[Mh] MeSH terms secundary: Female
Humans
Pregnancy
[Pt] Publication type:COMMENT; EDITORIAL
[Em] Entry month:1304
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:130225
[St] Status:MEDLINE

  8 / 1407 MEDLINE  
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[PMID]: 23178244
[Au] Autor:Baud D; Windrim R; Keunen J; Kelly EN; Shah P; van Mieghem T; Seaward PG; Ryan G
[Ad] Address:Fetal Medicine Unit, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
[Ti] Title:Fetoscopic laser therapy for twin-twin transfusion syndrome before 17 and after 26 weeks' gestation.
[So] Source:Am J Obstet Gynecol;208(3):197.e1-7, 2013 Mar.
[Is] ISSN:1097-6868
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The purpose of this study was to compare perinatal outcomes of pregnancies that undergo "early" (<17 weeks' gestation) or "late" (>26 weeks' gestation) fetoscopic laser ablation of placental vascular anastomoses for twin-twin transfusion syndrome (TTTS) with "conventional" cases that were treated at 17-26 weeks' gestation. STUDY DESIGN: We conducted a single center, retrospective analysis of 325 consecutive pregnancies that underwent fetoscopic laser therapy for severe TTTS. RESULTS: Twenty-four "early," 18 "late," and 283 "conventional" pregnancies with severe TTTS underwent laser therapy. Fetoscopy duration, gestation at delivery, survival rate, and complications were comparable among groups, except for preterm premature rupture of membranes at <7 days after laser therapy, which was more common in the "early" group than in either of the other 2 groups. CONCLUSION: Laser therapy for TTTS at <17 or >26 weeks' gestation has similar outcomes to procedures done at 17-26 weeks' gestation. We suggest that conventional gestational age guidelines of 16-26 weeks for laser therapy for TTTS should be reevaluated.
[Mh] MeSH terms primary: Fetofetal Transfusion/surgery
Fetoscopy/methods
Laser Therapy/methods
[Mh] MeSH terms secundary: Adolescent
Adult
Female
Gestational Age
Humans
Middle Aged
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Retrospective Studies
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1304
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:130225
[St] Status:MEDLINE

  9 / 1407 MEDLINE  
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[PMID]: 23021698
[Au] Autor:Vanderbilt DL; Schrager SM; Llanes A; Chmait RH
[Ad] Address:Division of General Pediatrics, Department of Pediatrics, Keck School of Medicin, University of Southern California, Los Angeles, CA, USA.
[Ti] Title:Prevalence and risk factors of cerebral lesions in neonates after laser surgery for twin-twin transfusion syndrome.
[So] Source:Am J Obstet Gynecol;207(4):320.e1-6, 2012 Oct.
[Is] ISSN:1097-6868
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To identify risk factors for cerebral lesions among survivors of twin-twin transfusion syndrome treated with laser surgery. STUDY DESIGN: A multilevel regression analysis examined risk factors for neonatal cerebral lesions identified by imaging. Imaging was routine in "high-risk survivors," defined as those delivered at <32 weeks' gestation, and by clinical indications if born later. Severe lesions were defined as: intraventricular hemorrhage grade III-IV, cystic periventricular leukomalacia, ventriculomegaly and/or hydrocephalus, microcephaly, infarctions, porencephalic/Dandy-Walker cysts, or bilateral other cysts. RESULTS: For 262 consecutive laser-treated twin-twin transfusion syndrome patients, 18 neonates had severe lesions identified among 427 individual survivors (4.2%) and 242 "high-risk survivors" (7.4%). Forty-six newborns had any cerebral lesion, resulting in lesion rates of 10.8%-19.0%. Delivery <32 weeks' (odds ratio, 4.95; P < .001) and <28 weeks' (odds ratio, 6.25; P < .001) gestation were associated with increased likelihood of any cerebral lesion. CONCLUSION: This cohort showed low rates (4-7%) of severe neonatal cerebral lesions, with prematurity being the primary risk factor.
[Mh] MeSH terms primary: Fetofetal Transfusion/surgery
Hydrocephalus/etiology
Intracranial Hemorrhages/etiology
Laser Therapy/adverse effects
Leukomalacia, Periventricular/etiology
[Mh] MeSH terms secundary: Female
Fetoscopy/adverse effects
Humans
Hydrocephalus/epidemiology
Infant, Newborn
Infant, Premature
Intracranial Hemorrhages/epidemiology
Leukomalacia, Periventricular/epidemiology
Pregnancy
Prevalence
Risk Factors
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1212
[Cu] Class update date: 130416
[Lr] Last revision date:130416
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:121001
[St] Status:MEDLINE

  10 / 1407 MEDLINE  
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[PMID]: 22682379
[Au] Autor:Saadai P; Farmer DL
[Ad] Address:Division of Pediatric Surgery, Department of Surgery, Fetal Treatment Center, University of California, San Francisco, 513 Parnassus Avenue, HSW 16-01, Box 0570, San Francisco, CA 94143-0570, USA. payam.saadai@ucsfmedctr.org
[Ti] Title:Fetal surgery for myelomeningocele.
[So] Source:Clin Perinatol;39(2):279-88, 2012 Jun.
[Is] ISSN:1557-9840
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Myelomeningocele (MMC) is a congenital neural tube defect that occurs in approximately 1 in 2900 live births in the United States. It is a devastating disability with significant morbidity and mortality within the first few decades of life. MMC was the first nonlethal disease to be considered and studied for fetal surgery and is now the most common open fetal surgery performed. The recently completed MOMS randomized controlled trial has shown that fetal repair for MMC can improve hydrocephalus and hindbrain herniation, can reduce the need for vetriculoperitoneal shunting, and may improve distal neurologic function in some patients.
[Mh] MeSH terms primary: Fetoscopy/methods
Fetus/surgery
Hydrocephalus/surgery
Meningomyelocele/surgery
Pregnancy Complications/surgery
Ventriculoperitoneal Shunt
[Mh] MeSH terms secundary: Female
Fetal Diseases/surgery
Fetus/physiopathology
Humans
Meningomyelocele/physiopathology
Pregnancy
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1301
[Cu] Class update date: 130416
[Lr] Last revision date:130416
[Js] Journal subset:IM
[Da] Date of entry for processing:120611
[St] Status:MEDLINE
[do] DOI:10.1016/j.clp.2012.04.003


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