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[PMID]: 29524461
[Au] Autor:Srinivasa RN; Chick JFB; Gemmete JJ; Hage AN; Srinivasa RN
[Ad] Address:Department of Radiology, Division of Vascular and Interventional Radiology, University of Michigan Health Systems, 1500 East Medical Center Drivem Ann Arbor, MI 48109.
[Ti] Title:Endolymphatic Interventions for the Treatment of Chylothorax and Chylous Ascites in Neonates: Technical and Clinical Success and Complications.
[So] Source:Ann Vasc Surg;, 2018 Mar 07.
[Is] ISSN:1615-5947
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: To report the technical and clinical success of performing minimally invasive endolymphatic embolization in neonates presenting with a chylothorax or chylous ascites. MATERIALS AND METHODS: 3 neonates, 2 males and 1 female, with a mean age of 28 days (range: 19-39 days) presented with a chylothorax (2) or chylous ascites (1) which was refractory to conservative management. All 3 patients (1 previously reported) underwent intranodal lymphangiography followed by thoracic duct embolization with 1 patient undergoing additional sclerosis of the retroperitoneal abdominal lymphatics. RESULTS: Lymphangiography, thoracic duct embolization, and sclerosis of the retroperitoneal abdominal lymphatics was technically successful. The chylothorax resolved in both patients. Persistent chylous ascites was noted after treatment that resolved after surgical placement of a vicryl mesh and fibrin sealant. 1 major complication occurred with non-target embolization of glue into the lungs requiring embolectomy. CONCLUSION: Thoracic duct and retroperitoneal abdominal lymphatic embolization can be performed in neonates. Resolution of chylothorax was seen in two patients (one previously reported) following embolization, while 1 patient with chylous ascites required surgical management after endolymphatic intervention.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 44656 MEDLINE  
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[PMID]: 29510686
[Au] Autor:Takei M; Obana A; Inomata T; Tanaka T; Shiang T; Bae Y; Takemura T; Murakami A
[Ad] Address:Department of Ophthalmology, Japan Red Cross Medical Center, 4-1-22, Hiroo, Shibuya-ku, Tokyo, Japan.
[Ti] Title:Fundus changes in type III membranoproliferative glomerulonephritis: a case report.
[So] Source:BMC Ophthalmol;18(1):72, 2018 Mar 06.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Membranoproliferative glomerulonephritis (MPGN) is characterized by mesangial cell proliferation and is classified into types I, II and III based on structural changes in the glomerular capillary walls. The drusen-like deposits of MPGN type II have been studied, but the fundus changes in MPGN type III have yet to be clarified. We report a case of MPGN type III with multiple deposits in the retinal pigment epithelium (RPE). CASE PRESENTATION: A 40-year-old Japanese woman with MPGN type III developed numerous yellow-white patches in the central macula of both eyes. Optical coherence tomography (OCT) showed deposits between the RPE and Bruch's membrane. Fluorescein angiography showed choroidal neovascularization (CNV) and OCT confirmed it as type 1 (sub RPE) CNV with fibrin tissue and subretinal fluid in the right eye. After 12months, the CNV and subretinal fluid resolved spontaneously but the RPE deposits remained in both eyes. Her final visual acuity was 20/20 in the right eye and 20/16 in the left eye. CONCLUSION: We report a case of MPGN type III with multiple deposits in the RPE and CNV, suggesting that various fundus changes occur in MPGN type III and careful fundus follow-up is necessary to prevent vision loss.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.1186/s12886-018-0738-x

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[PMID]: 29410160
[Au] Autor:Guedes AF; Carvalho FA; Domingues MM; Macrae FL; McPherson HR; Santos NC; Ariёns RAS
[Ad] Address:Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; Thrombosis and Tissue Repair Group, Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine and Multidisciplinary Cardiovascular Centre, Faculty of Med
[Ti] Title:Sensing adhesion forces between erythrocytes and γ' fibrinogen, modulating fibrin clot architecture and function.
[So] Source:Nanomedicine;14(3):909-918, 2018 Feb 02.
[Is] ISSN:1549-9642
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Plasma fibrinogen includes an alternatively spliced γ-chain variant (γ'), which mainly exists as a heterodimer (γAγ') and has been associated with thrombosis. We tested γAγ' fibrinogen-red blood cells (RBCs) interaction using atomic force microscopy-based force spectroscopy, magnetic tweezers, fibrin clot permeability, scanning electron microscopy and laser scanning confocal microscopy. Data reveal higher work necessary for RBC-RBC detachment in the presence of γAγ' rather than γAγA fibrinogen. γAγ' fibrinogen-RBCs interaction is followed by changes in fibrin network structure, which forms an heterogeneous clot structure with areas of denser and highly branched fibrin fibers. The presence of RBCs also increased the stiffness of γAγ' fibrin clots, which are less permeable and more resistant to lysis than γAγA clots. The modifications on clots promoted by RBCs-γAγ' fibrinogen interaction could alter the risk of thrombotic disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 44656 MEDLINE  
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[PMID]: 29388702
[Au] Autor:Soreide E; Denbeigh JM; Lewallen EA; Samsonraj RM; Berglund LJ; Dudakovic A; Cool SM; Nordsletten L; Kakar S; van Wijnen AJ
[Ad] Address:Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA 55905.
[Ti] Title:Fibrin glue mediated delivery of bone anabolic reagents to enhance healing of tendon to bone.
[So] Source:J Cell Biochem;, 2018 Feb 01.
[Is] ISSN:1097-4644
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Tendon graft healing in bone tunnels for the fixation of intra-articular ligament reconstructions may limit clinical outcome by delaying healing. This study assesses the effects of hydrogel-mediated delivery of bone anabolic growth factors in a validated model of tendon-to-bone tunnel healing. Forty-five Wistar rats were randomly allocated into three groups (BMP2-treated, GSK126-treated, and placebo). All animals underwent a tendon to bone tunnel reconstruction. Healing was evaluated at 4 weeks by biomechanical assessment, micro-computed tomography (bone mineral density, bone volume, cross sectional area of bone tunnels), and traditional histology. Adverse events associated with the hydrogel-mediated delivery of drugs were not observed. Results of our biomechanical assessment demonstrated favorable trends in animals treated with bone anabolic factors for, energy absorption (p = 0.116) and elongation (p = 0.054), while results for force to failure (p = 0.691) and stiffness (p = 0.404) did not show discernible differences. Cross sectional areas for BMP2-treated animals were reduced, but neither BMP2 nor GSK126 administration altered bone mineral density (p = 0.492) or bone volume in the bone tunnel. These results suggest a novel and positive effect of bone anabolic factors on tendon to bone tunnel healing. Histological evaluation confirmed absence of collagen fibers crossing the soft tissue-bone interface indicating immature graft integration as expected at this time point. Our study indicates that hydrogel-mediated delivery of BMP2 and GSK126 appears to be safe and has the potential to enhance tendon-to-bone-tunnel healing in ligament reconstructions. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:Publisher
[do] DOI:10.1002/jcb.26755

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[PMID]: 29309907
[Au] Autor:Seo J; Al-Hilal TA; Jee JG; Kim YL; Kim HJ; Lee BH; Kim S; Kim IS
[Ad] Address:Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
[Ti] Title:A targeted ferritin-microplasmin based thrombolytic nanocage selectively dissolves blood clots.
[So] Source:Nanomedicine;14(3):633-642, 2018 Jan 06.
[Is] ISSN:1549-9642
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The use of thrombolytic therapies is limited by an increased risk of systemic hemorrhage due to lysis of hemostatic clots. We sought to develop a plasmin-based thrombolytic nanocage that efficiently dissolves the clot without causing systemic fibrinolysis or disrupting hemostatic clots. Here, we generated a double chambered short-length ferritin (sFt) construct that has an N-terminal region fused to multivalent clot targeting peptides (CLT: CNAGESSKNC) and a C-terminal end fused to a microplasmin (Pn); CLT recognizes fibrin-fibronectin complexes in clots, Pn efficiently dissolves clots, and the assembly of double chambered sFt (CLT-sFt-Pn) into nanocage structure protects the activated-Pn from its circulating inhibitors. Importantly, activated CLT-sFt-Pn thrombolytic nanocage showed a prolonged circulatory life over activated-Pn and efficiently lysed the preexisting clots in both arterial and venous thromboses models. Thus, CLT-sFt-Pn thrombolytic nanocage platform represents the prototype of a targeted clot-busting agent with high efficacy and safety over existing thrombolytic therapies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  6 / 44656 MEDLINE  
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[PMID]: 29294343
[Au] Autor:Singh S; Houng AK; Reed GL
[Ad] Address:Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: satishsingh@email.arizona.edu.
[Ti] Title:Matrix Metalloproteinase-9 Mediates the Deleterious Effects of α2-Antiplasmin on Blood-Brain Barrier Breakdown and Ischemic Brain Injury in Experimental Stroke.
[So] Source:Neuroscience;376:40-47, 2017 Dec 30.
[Is] ISSN:1873-7544
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:During acute brain ischemia, α2-antiplasmin markedly enhances brain injury, blood-brain barrier breakdown and matrix metalloproteinase-9 (MMP-9) expression. Although α2-antiplasmin inhibits fibrin thrombus-degradation, and MMP-9 is a collagen-degrading enzyme altering blood-brain barrier, both have similar deleterious effects on the ischemic brain. We examined the hypothesis that MMP-9 is an essential downstream mediator of α2-antiplasmin's deleterious effects during brain ischemia. Middle cerebral artery thromboembolic stroke was induced in a randomized, blinded fashion in mice with increased blood levels of α2-antiplasmin. There was a robust increase in MMP-9 expression (immunofluorescence) in the ischemic vs. the non-ischemic hemisphere of MMP-9 but not MMP-9 mice, 24 h after stroke. Brain swelling and hemorrhage were significantly increased in the ischemic vs. the non-ischemic hemisphere of MMP-9 mice. By comparison to MMP-9 mice, the ischemic hemispheres of MMP-9 mice showed a ∼6-fold reduction in brain swelling (p < 0.001) and a ∼9-fold reduction in brain hemorrhage. Brain infarction (p < 0.0001) and TUNEL-positive cell death (p < 0.001) were significantly diminished in the ischemic hemisphere of MMP-9 mice vs. MMP-9 mice. Ischemic breakdown of the blood-brain barrier and fibrin deposition were also significantly reduced in MMP-9 mice vs. MMP-9 mice (p < 0.05), as measured by quantitative immunofluorescence. We conclude that MMP-9 deficiency ablates many of the deleterious effects of high α2-antiplasmin levels, significantly reducing blood-brain barrier breakdown, TUNEL-positive cell death, brain hemorrhage, swelling and infarction. This suggests that the two molecules may be in a shared pathway in which MMP-9 is essential downstream for the deleterious effects of α2-antiplasmin in ischemic stroke.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  7 / 44656 MEDLINE  
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[PMID]: 29524327
[Au] Autor:Lidn ; Karlsen TV; Guss B; Reed RK; Rubin K
[Ad] Address:Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5009, Bergen, Norway.
[Ti] Title:Integrin α can substitute for collagen-binding -integrins in vivo to maintain a homeostatic interstitial fluid pressure.
[So] Source:Exp Physiol;, 2018 Mar 10.
[Is] ISSN:1469-445X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:NEW FINDINGS: What is the central question of this study? Collagen-binding -integrins function physiologically in cellular control of dermal interstitial fluid pressure (P ) in vivo and thereby participate in control of extravascular fluid volume. During anaphylaxis, simulated by injection of Compound 48/80 integrin α takes over this physiological function. Here we addressed the question whether integrin α can replace collagen-binding -integrin to maintain a long-term homeostatic P . What is the main finding and its importance? Mice lacking the collagen-binding integrin α show a complex dermal phenotype with regard to the interstitial physiology apparent in the control of P . Notably dermal P is not lowered with Compound 48/80 in these animals. Our present data infer the integrin α to be the likely candidate that has taken over the role of collagen-binding -integrins for maintaining a steady-state homeostatic P . A better understanding of molecular processes involved in control of P is instrumental for establishing novel treatment regimens for control of edema formation in anaphylaxis and septic shock. ABSTRACT: Accumulated data indicate that cell-mediated contraction of reconstituted collagenous gels in vitro can serve as a model for cell-mediated control of interstitial fluid pressure (P ) in vivo. A central role for collagen-binding -integrins in both processes has been established. Furthermore, integrin α takes over the role of collagen-binding -integrins in mediating contraction after perturbations of collagen-binding -integrins in vitro. Integrin α is also instrumental for normalization of dermal P that has been lowered due to mast cell degranulation with Compound 48/80 (C48/80) in vivo. Here we demonstrate a role of integrin α in maintaining a long term homeostatic dermal P in mice lacking the collagen-binding integrin α (α11 mice). Measurements of P were performed after circulatory arrest. Furthermore, cell-mediated integrin α -directed contraction of collagenous gels in vitro depends on free access of a collagen-site known to bind several ECM proteins that form substrates for α -directed cell attachment, such as fibronectin and fibrin. A streptococcal collagen-binding protein, CNE, specifically binds to and block this site on the collagen triple helix. Here we show that whereas CNE perturbed α -directed and PDGF-BB induced normalization of dermal P after C48/80 it did not affect α -dependent maintenance of a homeostatic dermal P . These data imply that dynamic modifications of the ECM structure is needed during acute patho-physiologic modulations of P but not for long-term maintenance of a homeostatic P . Our data thus show that collagen-binding -integrins, integrin α and ECM-structure are potential targets for novel therapy aimed to modulate edema formation and hypovolemic shock during anaphylaxis. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1113/EP086902

  8 / 44656 MEDLINE  
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[PMID]: 29524029
[Au] Autor:Bahammam MA
[Ad] Address:Department of Periodontology, Faculty of Dentistry, King Abdulaziz University, P. O. Box 80209, Jeddah, 21589, Kingdom of Saudi Arabia. mbahammam@kau.edu.sa.
[Ti] Title:Effect of platelet-rich fibrin palatal bandage on pain scores and wound healing after free gingival graft: a randomized controlled clinical trial.
[So] Source:Clin Oral Investig;, 2018 Mar 09.
[Is] ISSN:1436-3771
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVE: This prospective randomized clinical trial was conducted to determine whether the application of a platelet-rich fibrin (PRF) palatal bandage after harvesting free gingival grafts (FGG) would improve healing of donor sites and decrease pain scores and patient discomfort. MATERIALS AND METHODS: Twenty-four patients received FGG to augment keratinized tissue dimensions. The application of a PRF bandage was decided randomly (n = 12 in each group). Patients reported their pain levels for the first 7days of healing using the visual analog scale (VAS), 101-point numerical rating scale (NRS-101), and 4-point verbal rating scale (VRS-4). The patients' pre-operative anxiety levels were measured using three anxiety scales. The healing of the donor sites was evaluated and compared to preoperative records. Data were assessed and recorded before surgery and at 1, 2, 3, 4, and 8weeks postoperatively. RESULTS: Dental anxiety and state-trait anxiety were evaluated at baseline and correlated to the postoperative pain scores. There were no significant differences in anxiety levels between the two groups; yet, they could potentially influence the outcome of any surgery and were included as covariates. The patients in the PRF group reported significantly lower pain scores and their pain levels returned to baseline levels earlier, compared to the control group. CONCLUSIONS: PRF palatal bandages significantly reduced postoperative pain and discomfort and facilitated wound healing after harvesting FGG. CLINICAL RELEVANCE: The study provided evaluation of patient-centered outcomes, which is timely, significant, and could benefit both periodontists and patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s00784-018-2397-y

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[PMID]: 29524025
[Au] Autor:Meschi N; Fieuws S; Vanhoenacker A; Strijbos O; Van der Veken D; Politis C; Lambrechts P
[Ad] Address:Department of Oral Health Sciences, Endodontology, KU Leuven & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a- box 7001, 3000 Leuven, Belgium. nastaran.meschi@kuleuven.be.
[Ti] Title:Root-end surgery with leucocyte- and platelet-rich fibrin and an occlusive membrane: a randomized controlled clinical trial on patients' quality of life.
[So] Source:Clin Oral Investig;, 2018 Mar 09.
[Is] ISSN:1436-3771
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The aim of this study was to investigate the impact of the adjunct of leukocyte- and platelet-rich fibrin (LPRF) to root-end surgery (RES) on the patients' quality of life during the first week post RES. MATERIALS AND METHODS: Patients in need of RES were recruited for an open randomized controlled clinical trial (RCT) with a 2 2 factorial design. They were randomly allocated to the test (+LPRF) and control (-LPRF) group. Each group was subsequently divided into two strata: with or without an occlusive membrane (Bio-Gide, Geistlich Biomaterials, Switzerland; BG). After RES, the patients completed daily for 1week a visual analog pain scale (VAS) and a 5-point Likert-type scale questionnaire concerning activity impairment, occurrence of symptoms, and medication use. RESULTS: Fifty patients were included, equally divided between the test and control group. Only one patient in the "-LPRF+BG-group" had to take additional antibiotics due to a persistent jaw swelling. There was no evidence (p ≤ 0.05) for a difference between the test and control group in VAS, occurrence of pain symptoms, impairment of daily activities, and medication use, over the 7days and daily during the 7days post RES. CONCLUSIONS: There was no statistical significant evidence for improvement of patients' quality of life during the first week post RES with LPRF in comparison with RES without LPRF. CLINICAL RELEVANCE: Although LPRF seems to be an inexpensive and autologous agent to reduce pain and swelling post RES, this RCT does not provide a statistical significant evidence for that.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s00784-018-2343-z

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[PMID]: 29523301
[Au] Autor:Wang X; Zhang Y; Ji W; Ao J
[Ad] Address:Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000 Guizhou, China; Joint Orthopaedic Research Center of Zunyi Medical University & University of Rochester Medical Center (JCMR-ZMU & URMC), Zunyi Medical University, Zunyi, 563000 Guizhou, China.
[Ti] Title:Categorising bone defect hematomas - Enhance early bone healing.
[So] Source:Med Hypotheses;113:77-80, 2018 Apr.
[Is] ISSN:1532-2777
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Fracture hematoma formation describes a transitional phase that involves a dynamic and tightly choreographed interaction between the fibrin matrix, cells, and cytokines that guides the ensuing bone repair. Here we propose a novel hypothesis to explain why hematomas in conjunction with critical sized bone defects are prone to differentiate into fibrous tissues, which eventually results in non-unions of the bone. We postulate that certain hematoma qualities are triggers that influence cell biological behaviours and that the release of certain growth factors determines what pattern of remodelling will prevail: intramembranous or endochondral ossification. A detailed characterization of the structural parameters of hematomas will allow researchers to create a microenvironment that aids the migration of mesenchymal stromal cells into the hematoma where, once established, they accelerate the bone healing process. Such a strategy would be particularly useful when faced with the complications arising from large recalcitrant bone defects that often fail to heal naturally.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process


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