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[PMID]: 28462446
[Au] Autor:Riedl CC; Pinker K; Ulaner GA; Ong LT; Baltzer P; Jochelson MS; McArthur HL; Gönen M; Dickler M; Weber WA
[Ad] Address:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. riedlc@mskcc.org.
[Ti] Title:Comparison of FDG-PET/CT and contrast-enhanced CT for monitoring therapy response in patients with metastatic breast cancer.
[So] Source:Eur J Nucl Med Mol Imaging;44(9):1428-1437, 2017 Aug.
[Is] ISSN:1619-7089
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: The aim of this study was to compare fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and contrast-enhanced computed tomography (CE-CT) for the prediction of progression-free survival (PFS) and disease-specific survival (DSS) in patients with stage IV breast cancer undergoing systemic therapy. METHODS: Sixty-five patients with metastatic breast cancer treated with first- or second-line systemic therapy in prospective clinical trials were included. Response to treatment was evaluated by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 for CE-CT and by PET Response Criteria in Solid Tumors (PERCIST), respectively. RESULTS: All responders by RECIST (n = 22) were also responders by PERCIST, but 40% (17/43) of non-responders by RECIST were responders by PERCIST. Responses according to RECIST and PERCIST both correlated with PFS, but PERCIST showed a significantly higher predictive accuracy (concordance index for PFS: 0.70 vs. 0.60). One-year PFS for responders vs. non-responders by RECIST was 59% vs. 27%, compared to 63% vs. 0% by PERCIST. Four-year DSS of responders and non-responders by RECIST was 50% and 38%, respectively (p = 0.2, concordance index: 0.55) as compared to 58% vs. 18% for PERCIST (p < 0.001, concordance index: 0.65). Response on PET/CT was also a significantly better predictor for DSS than disease control on CE-CT. CONCLUSIONS: In patients with metastatic breast cancer, tumor response on PET/CT appears to be a superior predictor of PFS and DSS than response on CE-CT. Monitoring tumor response by PET/CT may increase the power of clinical trials using tumor response as an endpoint, and may improve patient management in clinical routine.
[Mh] MeSH terms primary: Breast Neoplasms/pathology
Breast Neoplasms/therapy
Contrast Media
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Breast Neoplasms/diagnostic imaging
Disease-Free Survival
Female
Humans
Male
Middle Aged
Neoplasm Metastasis
Retrospective Studies
Treatment Outcome
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Contrast Media); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:170503
[St] Status:MEDLINE
[do] DOI:10.1007/s00259-017-3703-7

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[PMID]: 28456837
[Au] Autor:Ulaner GA; Castillo R; Wills J; Gönen M; Goldman DA
[Ad] Address:Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ulanerg@mskcc.org.
[Ti] Title:F-FDG-PET/CT for systemic staging of patients with newly diagnosed ER-positive and HER2-positive breast cancer.
[So] Source:Eur J Nucl Med Mol Imaging;44(9):1420-1427, 2017 Aug.
[Is] ISSN:1619-7089
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVES: This study assesses F-FDG-PET/CT for patients with newly diagnosed estrogen receptor-positive/human epidermal growth factor receptor-negative (ER+/HER2-) and human epidermal growth factor receptor-positive (HER2+) breast cancer. METHODS: In this Institutional Review Board-approved retrospective study, our Healthcare Information System was screened for patients with ER+/HER2- and HER2+ breast cancer who underwent F-FDG-PET/CT prior to systemic or radiation therapy. The initial stage was determined from mammography, ultrasound, magnetic resonance imaging, and/or surgery. F-FDG-PET/CT was evaluated to identify unsuspected extra-axillary regional nodal and distant metastases. The proportion of patients upstaged overall and stratified by stage and receptor phenotypes was calculated along with confidence intervals (CI). RESULTS: A total of 238 patients with ER+/HER2- and 245 patients with HER2+ who met inclusion criteria were evaluated. For patients with ER+/HER2-breast cancer, F-FDG-PET/CT revealed unsuspected distant metastases in 3/71 (4%) initial stage IIA, 13/95 (14%) stage IIB, and 15/57 (26%) stage III. For patients with HER2+ breast cancer, F-FDG-PET/CT revealed unsuspected distant metastases in 3/72 (4%) initial stage IIA, 13/93 (14%) stage IIB, and 13/59 (22%) stage III. The overall upstaging rate for IIB was 14% (95% confidence interval (CI): 9-20%). CONCLUSIONS: F-FDG-PET/CT revealed distant metastases in 14% (95% CI: 9-20%) of patients with stage IIB ER+/HER2- and HER2+ breast cancer, which is similar to upstaging rates previously seen in patients with stage IIB triple-negative breast cancer (15%, 95% CI: 9-24%). The detection of unsuspected distant metastases in these patients alters treatment and prognosis. NCCN guidelines should consider adding patients with stage IIB breast cancer for consideration of systemic staging with F-FDG-PET/CT at the time of initial diagnosis.
[Mh] MeSH terms primary: Breast Neoplasms/diagnostic imaging
Breast Neoplasms/pathology
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
Receptor, ErbB-2/metabolism
Receptors, Estrogen/metabolism
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Breast Neoplasms/metabolism
Female
Humans
Middle Aged
Neoplasm Staging
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Receptors, Estrogen); 0Z5B2CJX4D (Fluorodeoxyglucose F18); EC 2.7.10.1 (ERBB2 protein, human); EC 2.7.10.1 (Receptor, ErbB-2)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:170501
[St] Status:MEDLINE
[do] DOI:10.1007/s00259-017-3709-1

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[PMID]: 27770402
[Au] Autor:Soufi M; Kamali-Asl A; Geramifar P; Rahmim A
[Ad] Address:Department of Radiation Medicine Engineering, Shahid Beheshti University, Tehran, Iran.
[Ti] Title:A Novel Framework for Automated Segmentation and Labeling of Homogeneous Versus Heterogeneous Lung Tumors in [ F]FDG-PET Imaging.
[So] Source:Mol Imaging Biol;19(3):456-468, 2017 06.
[Is] ISSN:1860-2002
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Determination of intra-tumor high-uptake area using 2-deoxy-2-[ F]fluoro-D-glucose ([ F]FDG) positron emission tomography (PET) imaging is an important consideration for dose painting in radiation treatment applications. The aim of our study was to develop a framework towards automated segmentation and labeling of homogeneous vs. heterogeneous tumors in clinical lung [ F]FDG-PET with the capability of intra-tumor high-uptake region delineation. PROCEDURES: We utilized and extended a fuzzy random walk PET tumor segmentation algorithm to delineate intra-tumor high-uptake areas. Tumor textural feature (TF) analysis was used to find a relationship between tumor type and TF values. Segmentation accuracy was evaluated quantitatively utilizing 70 clinical [ F]FDG-PET lung images of patients with a total of 150 solid tumors. For volumetric analysis, the Dice similarity coefficient (DSC) and Hausdorff distance (HD) measures were extracted with respect to gold-standard manual segmentation. A multi-linear regression model was also proposed for automated tumor labeling based on TFs, including cross-validation analysis. RESULTS: Two-tailed t test analysis of TFs between homogeneous and heterogeneous tumors revealed significant statistical difference for size-zone variability (SZV), intensity variability (IV), zone percentage (ZP), proposed parameters II and III, entropy and tumor volume (p < 0.001), dissimilarity, high intensity emphasis (HIE), and SUV (p < 0.01). Lower statistical differences were observed for proposed parameter I (p = 0.02), and no significant differences were observed for SUV and SUV . Furthermore, the Spearman rank analysis between visual tumor labeling and TF analysis depicted a significant correlation for SZV, IV, entropy, parameters II and III, and tumor volume (0.68 ≤ ρ ≤ 0.84) and moderate correlation for ZP, HIE, homogeneity, dissimilarity, parameter I, and SUV (0.22 ≤ ρ ≤ 0.52), while no correlations were observed for SUV and SUV (ρ < 0.08). The multi-linear regression model for automated tumor labeling process resulted in R and RMSE values of 0.93 and 0.14, respectively (p < 0.001), and generated tumor labeling sensitivity and specificity of 0.93 and 0.89. With respect to baseline random walk segmentation, the results showed significant (p < 0.001) mean DSC, HD, and SUV error improvements of 21.4 ± 11.5 %, 1.4 ± 0.8 mm, and 16.8 ± 8.1 % in homogeneous tumors and 7.4 ± 4.4 %, 1.5 ± 0.6 mm, and 7.9 ± 2.7 % in heterogeneous lesions. In addition, significant (p < 0.001) mean DSC, HD, and SUV error improvements were observed for tumor sub-volume delineations, namely 5 ± 2 %, 1.5 ± 0.6 mm, and 7 ± 3 % for the proposed Fuzzy RW method compared to RW segmentation. CONCLUSION: We proposed and demonstrated an automatic framework for significantly improved segmentation and labeling of homogeneous vs. heterogeneous tumors in lung [ F]FDG-PET images.
[Mh] MeSH terms primary: Algorithms
Fluorodeoxyglucose F18/chemistry
Image Processing, Computer-Assisted
Lung Neoplasms/diagnostic imaging
Positron-Emission Tomography
[Mh] MeSH terms secundary: Automation
Fuzzy Logic
Humans
Linear Models
Lung Neoplasms/pathology
Staining and Labeling
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:161023
[St] Status:MEDLINE
[do] DOI:10.1007/s11307-016-1015-0

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[PMID]: 29489658
[Au] Autor:Huang KH; Tai MC; Lee LC; Weng TH; Chen YH; Lin LF; Chen JT; Lu DW; Chen CL
[Ad] Address:Department of Ophthalmology, Tri-Service General Hospital.
[Ti] Title:Positron emission tomography/computed tomography scan of Vogt-Koyanagi-Harada syndrome with associated autoimmune thyroid disease: A case report and literature review.
[So] Source:Medicine (Baltimore);97(9):e0047, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Vogt-Koyanagi-Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of F-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of VKH syndrome with AITD and to perform a literature review on the association between the 2 diseases. PATIENT CONCERNS: A 55-year-old woman without the history of ocular trauma suffered from chronic headache. She was presented with painful blurred vision of both eyes with headache for 2 weeks. Ophthalmic evaluations revealed panuveitis, exudative retinal detachment, and papilloedema in both eyes. The clinical symptoms and presentations are compatible with the diagnosis of VKH syndrome. Other examinations for intraocular infection, malignancy, and lupus choroidopathy were of negative results. The result of contrast-enhanced computed tomography (CT) of the brain was normal. Due to the history of cancer in the patient's families, a F-FDG PET/CT whole-body scan was performed. The result indicated a focal of 2-fluoro-2-deoxy-D-glucose (FDG) uptake at the right upper lobe of the thyroid. Therefore, the patient's thyroid function was examined and the result indicated euthyroidism with detectable thyroid peroxidase/thyroglobulin antibodies. DIAGNOSES: VKH syndrome with associated AITD. INTERVENTIONS: Treatment with intravenous pulse systemic methylprednisolone (1000 mg daily) was prescribed for 3 days and then shifted gradually to tapered oral steroid medication. OUTCOMES: Symptoms of papillitis and serous retinal detachment of VKH syndrome was relieved after steroid treatment LESSONS:: F-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) can be used for the effective diagnosis of VKH syndrome with AITD.
[Mh] MeSH terms primary: Positron Emission Tomography Computed Tomography
Thyroiditis, Autoimmune/complications
Thyroiditis, Autoimmune/diagnostic imaging
Uveomeningoencephalitic Syndrome/complications
Uveomeningoencephalitic Syndrome/diagnostic imaging
[Mh] MeSH terms secundary: Female
Fluorodeoxyglucose F18
Glucocorticoids/therapeutic use
Headache/etiology
Humans
Methylprednisolone/therapeutic use
Middle Aged
Thyroiditis, Autoimmune/drug therapy
Uveomeningoencephalitic Syndrome/drug therapy
Vision Disorders/etiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Glucocorticoids); 0Z5B2CJX4D (Fluorodeoxyglucose F18); X4W7ZR7023 (Methylprednisolone)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000010047

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[PMID]: 29480842
[Au] Autor:Chang CC; Cho SF; Chuang YW; Lin CY; Huang YF; Tyan YC
[Ad] Address:Department of Nuclear Medicine, Kaohsiung Medical University Hospital.
[Ti] Title:Prognostic significance of retention index of bone marrow on dual-phase 18F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with diffuse large B-cell lymphoma.
[So] Source:Medicine (Baltimore);97(2):e9513, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The purpose of this study was to determine the prognostic significance of F-18 fluorodeoxyglucose (FDG) uptake on a dual-phase positron emission tomography/computed tomography (PET/CT), focusing on the increment in maximal standardized uptake value (SUVinc) of tumor and bone marrow (BM) between initial and delayed phase images and retention index (RI) of tumor and BM, in patients with diffuse large B-cell lymphoma (DLBCL).From September 2009 to January 2013, 70 patients (37 males and 33 females, aged 60.6 ±â€Š17.5 years) with DLBCL who had undergone dual-phase FDG PET/CT scans for pretreatment staging were enrolled. The patients subsequently received combination chemotherapy with rituximab. The dual-phase SUV, including SUVinc of tumor (SUVinc-t), RI of tumor (RI-t), SUVinc of BM, and RI of BM were measured. The clinical observation period was from September 2009 to December 2014. Both univariate and multivariate analyses were then used to assess the prognostic significance of SUVinc, RI, international prognostic index (IPI), gender, age, clinical stage, and laboratory tests.The median follow-up time was 35.5 months. The 3-year overall survival (OS) for patients with low/high SUVinc-t (cut-off 2.0) and for patients with low/high RI-t (cut-off 20) were 87.5%/ 62.1% (P = .08) and 83.3%/ 62.7% (P = .14), respectively. The 3-year OS for patients with SUVinc-i < 0.35 and for those with SUVinc-i ≥ 0.35 were 73.2% and 53.3%, respectively (P = .10). The 3-year OS for patients with RI-i < 45 and for those with RI-i ≥ 45 were 72.7% and 37.5%, respectively (P = .02). Subsequently, the Cox multivariate forward proportional hazards model revealed that a higher RI-i (hazard ratio: 4.49; 95% confidence interval: 1.64-12.32; P = .0035) and IPI were independent prognostic factors affecting OS.For patients with DLBCL, an elevated RI-i (≥45) was a predictor for shorter OS, independent of IPI score. It added to the value of pretreatment dual-phase FDG PET/CT scans.
[Mh] MeSH terms primary: Bone Marrow/diagnostic imaging
Fluorodeoxyglucose F18
Lymphoma, Large B-Cell, Diffuse/diagnostic imaging
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Antineoplastic Agents, Immunological/therapeutic use
Bone Marrow/drug effects
Bone Marrow/metabolism
Female
Follow-Up Studies
Humans
Lymphoma, Large B-Cell, Diffuse/drug therapy
Lymphoma, Large B-Cell, Diffuse/metabolism
Male
Middle Aged
Multivariate Analysis
Prognosis
Retrospective Studies
Rituximab/therapeutic use
Survival Analysis
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antineoplastic Agents, Immunological); 0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 4F4X42SYQ6 (Rituximab)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009513

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[PMID]: 28451717
[Au] Autor:Send T; Kreppel B; Gaertner FC; Bundschuh RA; Strunk H; Bootz F; Essler M
[Ad] Address:Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde/-Chirurgie, Universitätsklinikum Bonn, Bonn, Deutschland.
[Ti] Title:PET-CT bei Karzinomen im Kopf­Hals­Bereich. [PET-CT in head and neck cancer].
[So] Source:HNO;65(6):504-513, 2017 Jun.
[Is] ISSN:1433-0458
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:The importance of F-fluorodesoxyglucose positron-emission tomography (FDG-PET) for the diagnosis of malignant disease is increasing. On one hand, this is due to the high sensitivity of this method, on the other, because the entire body can be examined. FDG-PET can be particularly advantageous for the diagnosis of head and neck tumors, where tumor staging is an important prognostic parameter and essentially determines the therapeutic regimen. This article presents the different possibilities for combined evaluation with PET and computed tomography (CT) for the diagnosis of patients with head and neck cancer. Special focus is placed on primary staging and tumor follow-up, as well as on the role of PET-CT in the diagnosis of patients with cancer of unknown primary origin (CUP). The use of PET-CT for radiotherapy planning and new aspects of PET technology are also discussed.
[Mh] MeSH terms primary: Fluorodeoxyglucose F18
Head and Neck Neoplasms/diagnostic imaging
Head and Neck Neoplasms/pathology
Positron Emission Tomography Computed Tomography/methods
[Mh] MeSH terms secundary: Evidence-Based Medicine
Humans
Image Enhancement/methods
Neoplasm Staging
Radiopharmaceuticals
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s00106-017-0355-7

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[PMID]: 29458956
[Au] Autor:Adams SJ; Rakheja R; Bryce R; Babyn PS
[Ad] Address:Department of Medical Imaging, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic address: scott.adams@usask.ca.
[Ti] Title:Incidence and Economic Impact of Incidental Findings on F-FDG PET/CT Imaging.
[So] Source:Can Assoc Radiol J;69(1):63-70, 2018 Feb.
[Is] ISSN:1488-2361
[Cp] Country of publication:Canada
[La] Language:eng
[Ab] Abstract:PURPOSE: The study sought to determine the incidence of incidental findings on whole-body positron emission tomography with computed tomography (PET/CT) imaging and the average costs of investigations to follow-up or further characterize incidental findings. METHODS: Imaging reports of 215 patients who underwent whole-body PET/CT imaging were retrospectively reviewed. Our provincial picture archiving and communication system was queried and patient charts were reviewed to identify all investigations performed to follow-up incidental findings within 1 year of the initial PET/CT study. Costs of follow-up imaging studies (professional and technical components) and other diagnostic tests and procedures were determined in Canadian dollars (CAD) and U.S. dollars (USD) using the 2015 Ontario Health Insurance Plan Schedule of Benefits and Fees and 2016 U.S. Medicare Physician Fee Schedule, respectively. RESULTS: At least 1 incidental finding was reported in 161 reports (74.9%). The mean number of incidental findings ranged from 0.64 in patients <45 years of age to 2.2 in patients 75 years of age and older. Seventy-five recommendations for additional investigations were made for 64 (30%) patients undergoing PET/CT imaging, and 14 of those were carried out specifically to follow-up incidental findings. Averaged across all 215 patients, the total cost of investigations recommended to follow-up incidental findings was CAD$105.51 (USD$127.56) per PET/CT study if all recommendations were acted on, and CAD$22.77 (USD$29.14) based on investigations actually performed. CONCLUSIONS: As the incidence of incidental findings increases with age and a larger proportion of elderly patients is expected as population demographics change, it will be increasingly important to consider incidental findings on PET/CT imaging with standardized approaches to follow-up.
[Mh] MeSH terms primary: Fluorodeoxyglucose F18
Incidental Findings
Positron Emission Tomography Computed Tomography/methods
Radiopharmaceuticals
Whole Body Imaging/methods
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Incidence
Infant
Male
Middle Aged
Ontario
Retrospective Studies
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[Js] Journal subset:IM
[Da] Date of entry for processing:180221
[St] Status:MEDLINE

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[PMID]: 29390326
[Au] Autor:Wang M; Jiang S; Zhang Y; Jiang C; Xia F; Lyu W; Ma X
[Ad] Address:Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center.
[Ti] Title:The application of 18F-FDG PET/CT in ovarian immature teratomas when pathological examination results contradict clinical observations: a case report.
[So] Source:Medicine (Baltimore);96(50):e9171, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could reveal potential lymph node involvement and assisted locating sample sites for pathological examinations. PATIENT CONCERNS: Help choose the right treatment strategies for patients. To better stage immature ovarian teratomas with 18F-FDG PET/CT when lymphatic metastasis is suspected while lymph node biopsy results are negative. DIAGNOSES: The ultimate pathological diagnosis was left ovarian cancer, an immature teratoma (IMT) Grade 1. INTERVENTIONS: Surgery was the initial treatment option. Chemotherapy (BEP scheme: Bleomycin 30 mg d1, 7 + Etoposide 100mg d1-6 + Cisplatin 50mg d1-3) was then administered. OUTCOMES: The post-operational pathological examination additionally showed a small number of tumor cells in para-aortic lymph nodes. The end-of-treatment disclosed no recurrent tumors and serum levels of AFP (2.9 ng/mL), hCG (0.12 mIU/L), and CA-125 (11.4 IU/mL) were normal. LESSONS: 18F-FDG PET/CT successfully detected lymphatic metastasis when lymph node biopsy results were negative, which would be of great significance in detecting metastasis and monitoring reoccurrence of ovarian immature teratomas.
[Mh] MeSH terms primary: Ovarian Neoplasms/diagnostic imaging
Ovarian Neoplasms/pathology
Positron Emission Tomography Computed Tomography
Teratoma/diagnostic imaging
Teratoma/pathology
[Mh] MeSH terms secundary: Adolescent
Combined Modality Therapy
Female
Fluorodeoxyglucose F18
Humans
Lymphatic Metastasis/diagnostic imaging
Ovarian Neoplasms/therapy
Radiopharmaceuticals
Teratoma/therapy
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009171

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[PMID]: 29390293
[Au] Autor:Park S; Yoon JK; Jin Lee S; Kang SY; Yim H; An YS
[Ad] Address:Department of Nuclear Medicine and Molecular Imaging.
[Ti] Title:Prognostic utility of FDG PET/CT and bone scintigraphy in breast cancer patients with bone-only metastasis.
[So] Source:Medicine (Baltimore);96(50):e8985, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We performed this retrospective clinical study to examine the prognostic power of bone scintigraphy (BS) and F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in terms of overall survival (OS) of breast cancer with bone-only metastasis.We retrospectively evaluated 100 female invasive ductal breast cancer patients (mean age 48.1 years) with bone-only metastasis. Twenty-five patients had human epidermal growth factor receptor 2 (HER2)-positive tumors, 65 were estrogen receptor (ER) and/or progesterone receptor (PR)-positive, HER2-negative tumors, and 10 were triple negative tumors. The patients were treated properly with various treatments, including chemotherapy, radiotherapy, hormone, and bisphosphonate therapy, based on their clinical status. All patients underwent BS and FDG PET/CT at baseline and 1 year after treatment. The baseline and follow images were visually compared, and the patients were grouped as responders or nonresponders based on their images. OS was compared between the groups.The mean OS after the diagnosis of bone-only metastasis was 57.6 months. Fifty-one patients (51%) died within 5 years after diagnosis of metastasis. No difference in survival was evident between responders and nonresponders based on BS imaging data (P = .090). The response status based on PET imaging data waste only significant independent prognostic factor on multivariate analysis (P = .001). Survival was lower in nonresponders than in responders based on PET imaging (32.7% vs 66.4%; P < .001).Our findings suggest that the response status according to FDG PET imaging can be used to predict OS in breast cancer patients with bone-only metastasis.
[Mh] MeSH terms primary: Bone Neoplasms/diagnostic imaging
Bone Neoplasms/pathology
Breast Neoplasms/diagnostic imaging
Breast Neoplasms/secondary
Positron Emission Tomography Computed Tomography
[Mh] MeSH terms secundary: Bone Neoplasms/therapy
Breast Neoplasms/therapy
Female
Fluorodeoxyglucose F18
Humans
Middle Aged
Predictive Value of Tests
Prognosis
Radiopharmaceuticals
Retrospective Studies
Survival Rate
[Pt] Publication type:CLINICAL STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008985

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[PMID]: 29182373
[Au] Autor:Nakajo M; Jinguji M; Shinaji T; Nakajo M; Aoki M; Tani A; Sato M; Yoshiura T
[Ad] Address:1 Department of Radiology, Kagoshima University, Graduate School of Medical and Dental Sciences , Kagoshima , Japan.
[Ti] Title:Texture analysis of F-FDG PET/CT for grading thymic epithelial tumours: usefulness of combining SUV and texture parameters.
[So] Source:Br J Radiol;91(1083):20170546, 2018 Feb.
[Is] ISSN:1748-880X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To retrospectively investigate the standardized uptake value (SUV)-related and heterogeneous texture parameters individually and in combination for differentiating between low- and high-risk Fluorone-fludeoxyglucose ( F-FDG)-avid thymic epithelial tumours (TETs) with positron emission tomography (PET)/CT. METHODS: SUV-related and 6 texture parameters (entropy, homogeneity, dissimilarity, intensity variability, size-zone variability and zone percentage) were compared between 11 low-risk and 23 high-risk TETs (metabolic tumour volume >10.0 cm and SUV ≥2.5). Diagnostic performance was evaluated by receiver operating characteristic analysis. The diagnostic value of combining SUV and texture parameters was examined by a scoring system. RESULTS: High-risk TETs were significantly higher in SUVmax (p = 0.022), entropy (p = 0.038), intensity variability (p = 0.041) and size-zone variability (p = 0.045) than low-risk TETs. Diagnostic accuracies of these 4 parameters, dissimilarity and zone percentage which also showed significance in receiver operating characteristic analysis ranged between 64.7 and 73.5% without significant differences in AUC (range; 0.71 to 0.75) (p ≥ 0.05 each). Each parameter was scored as 0 (negative for high-risk) or 1 (positive for high-risk) according to each threshold criterion, then scores were summed [0 or 1 for low-risk TETs (median; 1); ≥2 for high-risk TETs (median; 4)]. The sensitivity, specificity and accuracy of detecting high-risk TETs were 100, 81.8 and 94.1%, respectively, with an AUC of 0.99. CONCLUSION: The diagnostic performances of individual SUVmax and texture parameters were relatively low. However, combining these parameters can significantly increase diagnostic performance when differentiating between relatively large low- and high-risk F-FDG-avid TETs. Advances in knowledge: Combined use of SUVmax and texture parameters can significantly increase the diagnostic performance when differentiating between low- and high-risk TETs.
[Mh] MeSH terms primary: Neoplasms, Glandular and Epithelial/diagnostic imaging
Neoplasms, Glandular and Epithelial/pathology
Positron Emission Tomography Computed Tomography/methods
Thymus Neoplasms/diagnostic imaging
Thymus Neoplasms/pathology
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Female
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Radiopharmaceuticals
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171129
[St] Status:MEDLINE
[do] DOI:10.1259/bjr.20170546


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