Database : MEDLINE Search on : gadolinium [Words] References found : 22756 [refine] Displaying: 1 .. 10   in format [Detailed]

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[PMID]: 23648538 [Au] Autor: Natsume M; Sano H; Fukusada S; Kachi K; Inoue T; Anbe K; Nishie H; Nishi Y; Yoshimura N; Mizushima T; Okumura F; Miyabe K; Naitoh I; Hayashi K; Nakazawa T [Ad] Address: Department of Gastroenterology, Gifu Prefectural Tajimi Hospital. [Ti] Title: Gadolinium as an alternative radiocontrast agent in patients with allergy to iodine-based contrast provide for useful diagnostic imagings and safely treatment of biliary tract diseases. [So] Source: Nihon Shokakibyo Gakkai Zasshi;110(5):825-32, 2013 May. [Is] ISSN: 0446-6586 [Cp] Country of publication: Japan [La] Language: eng [Ab] Abstract: Diagnosis and treatment of biliary tract disease requires an intraductal radiocontrast agent. Although iodine-based contrast medium is commonly used, some patients show severe allergy to iodinated contrast agent. We have retrospectively reviewed the usefulness and safety of gadolinium as an alternative radiocontrast agent in 3 patients with allergy to iodine-based contrast medium in the diagnosis and treatment of biliary tract diseases. In case 1, percutaneous transhepatic biliary drainage and cholangiography were performed successfully and it was possible to visualize an intrahepatic bile duct stone. Percutaneous transhepatic cholangioscopic lithotomy was performed and the intrahepatic bile duct stone was removed. In case 2, endoscopic biliary lithotripsy was performed. In case 3, percutaneous transhepatic cholangiography and cholangioscopy provided a diagnosis of moderately differentiated carcinoma. He underwent pancreatoduodenectomy. Postoperative cholangiograms were also obtained successfully. Gadolinium contrast agent is an alternative to iodine-based cholangiography for the patients with allergy to iodine. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review

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[PMID]: 23648986 [Au] Autor: Al-Sous MW; Bohlega SA; Al-Kawi MZ; McLean DR; Ghaus SN [Ad] Address: Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia. [Ti] Title: Polyradiculopathy. A rare complication of neurobrucellosis. [So] Source: Neurosciences (Riyadh);8(1):46-9, 2003 Jan. [Is] ISSN: 1319-6138 [Cp] Country of publication: Saudi Arabia [La] Language: eng [Ab] Abstract: Neurobrucellosis is chronic brucellosis affecting the nervous system. It may mimic many neurological diseases but it rarely presents as polyradiculopathy. Brucellar radiculopathy was diagnosed in 6 patients who presented with weakness of the lower extremities. Five patients had lumbar puncture, 4 had magnetic resonance imaging of lumbar spine and 4 had nerve conduction studies. Five patients had areflexia and weakness; one had areflexia with proprioceptive ataxia. All patients had positive Brucella serology; cerebrospinal fluid showed lymphocytic pleocytosis, elevated protein, normal-low glucose; brucella serology was positive in all specimens. Nerve conduction studies showed absent F-wave in 2 patients and polyradiculopathy with secondary motor axonopathy in 2 patients; motor conduction velocity was normal in all. Magnetic resonance imaging with gadolinium injection showed enhancement of lumbar nerve root in 3 patients, and no enhancement in one. All patients improved after treatment with antibiotics and lumbar root enhancement disappeared. Symptoms of myelopathy were unmasked after radiculopathy had resolved in one patient. In endemic areas, brucella infection should be considered in the differential diagnosis of radiculopathy. Radiculopathy is probably due to inflammation of the meninges and the intrathecal portion of the roots. The pathogenesis of myelopathy may involve demyelination as spasticity persists or worsens after radiculopathy improves. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [St] Status: In-Data-Review

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[PMID]: 23290478 [Au] Autor: Costelloe CM; Madewell JE; Kundra V; Harrell RK; Bassett RL; Ma J [Ad] Address: Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: ccostelloe@mdanderson.org. [Ti] Title: Conspicuity of bone metastases on fast Dixon-based multisequence whole-body MRI: Clinical utility per sequence. [So] Source: Magn Reson Imaging;31(5):669-75, 2013 Jun. [Is] ISSN: 1873-5894 [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: PURPOSE: The purpose of the study was to evaluate the conspicuity of bone metastases on each of the numerous sequences produced by fast Dixon-based multisequence whole-body (WB) magnetic resonance imaging (MRI) scanning in order to determine the most clinically useful sequences overall and per anatomic region. MATERIALS AND METHODS: Twenty-seven breast cancer patients with bone metastases were prospectively studied with fast Dixon-based WB MRI including head/neck, chest, abdominal, pelvic, thigh, calf/feet and either cervical, thoracic and lumbar or cervical/thoracic and thoracic/lumbar regions. Sequences included coronal T2, axial T1 without and with intravenous gadolinium (+C), sagittal T1 spine+C, each associated fat-only (FO) and fat-saturated (FS) sequence, axial diffusion-weighted imaging (DWI) and short tau inversion recovery (STIR). Blinded reviewers evaluated lesion conspicuity, a surrogate of clinical utility, on a five-point scale per anatomic region. Sequences were compared using analysis of variance, differences were detected with Tukey's honestly significant difference test, and the four sequences with highest mean conspicuity were compared to the remainder overall and per anatomic region. RESULTS: Overall, a significant lesion conspicuity difference was found (P<.0001), and lesion conspicuity was significantly higher on FS T1+C, FO T1+C, T1+C sagittal and FS T1+C axial sequences (P<.0001). Per-region results were the same in the head/neck. Other sequences overlapped with these and included the following: chest/abdomen - FO T2, DWI; pelvis - DWI, FO T2; thigh - FS T2, FO T2, FO T1+C; calf/feet - FS T2, DWI, FO T2, STIR. CONCLUSION: Overall, bone lesions were most conspicuous on FS T1+C sagittal, FO T1+C sagittal, T1+C sagittal and FS T1+C axial fast Dixon WB MRI sequences. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review

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[PMID]: 23090410 [Au] Autor: Deli M; Fritz J; Mateiescu S; Busch M; Carrino JA; Becker J; Garmer M; Grönemeyer D [Ad] Address: Department of Radiology and Microtherapy, Groenemeyer Institute for Microtherapy (GIMT), University of Witten/Herdecke, Universitaetsstrasse 142, 44799, Bochum, Germany, martin.deli@web.de. [Ti] Title: Saline as the Sole Contrast Agent for Successful MRI-guided Epidural Injections. [So] Source: Cardiovasc Intervent Radiol;36(3):748-55, 2013 Jun. [Is] ISSN: 1432-086X [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: PURPOSE: To assess the performance of sterile saline solution as the sole contrast agent for percutaneous magnetic resonance imaging (MRI)-guided epidural injections at 1.5 T. METHODS: A retrospective analysis of two different techniques of MRI-guided epidural injections was performed with either gadolinium-enhanced saline solution or sterile saline solution for documentation of the epidural location of the needle tip. T1-weighted spoiled gradient echo (FLASH) images or T2-weighted single-shot turbo spin echo (HASTE) images visualized the test injectants. Methods were compared by technical success rate, image quality, table time, and rate of complications. RESULTS: 105 MRI-guided epidural injections (12 of 105 with gadolinium-enhanced saline solution and 93 of 105 with sterile saline solution) were performed successfully and without complications. Visualization of sterile saline solution and gadolinium-enhanced saline solution was sufficient, good, or excellent in all 105 interventions. For either test injectant, quantitative image analysis demonstrated comparable high contrast-to-noise ratios of test injectants to adjacent body substances with reliable statistical significance levels (p < 0.001). The mean table time was 22 ± 9 min in the gadolinium-enhanced saline solution group and 22 ± 8 min in the saline solution group (p = 0.75). CONCLUSION: Sterile saline is suitable as the sole contrast agent for successful and safe percutaneous MRI-guided epidural drug delivery at 1.5 T. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1007/s00270-012-0489-7

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[PMID]: 23646680 [Au] Autor: He R; Xing G; Wang X; Jiao Y; Zhao H; Yuan H; Wang S; Dong J; Lei H [Ad] Address: State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. [Ti] Title: Synthesis and evaluation of Bingel-Hirsch multiadducts of paramagnetic gadofullerene as potential magnetic resonance imaging contrast agents. [So] Source: J Nanosci Nanotechnol;13(2):1549-54, 2013 Feb. [Is] ISSN: 1533-4880 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Water-soluble malonate multiadducts of paramagnetic gadolinium endohedral metallofullerene, Gd@C82[C(COOH)2]6 and Gd@C82[C(COOH)2]8, were synthesized by Bingel-Hirsch reaction. Gd@C82 was firstly reacted with diethyl bromomalonate in the presence of alkali metal hydride to produce malonic ester multiadducted derivatives, Gd@C82[C(COOCH2CH3)2]x (x = 3-8), by Bingel reaction. They were isolated and purified to obtain Gd@C82[C(COOCH2CH3)2]6 and Gd@C82[C(COOCH2CH3)2]8 by silica-gel column chromatography with a gradient elution method, which were subsequently hydrolyzed to yield water-soluble Gd@C82[C(COOH)2]6 and Gd@C82[C(COOH)2]8 by Hirsch reaction. The structures of the derivatives were characterized by Fourier transform infrared spectrometry and matrix assisted laser desorption ionization time-of-flight mass spectrometry. The longitudinal relaxivities of Gd@C82[C(COOH)2]8 and Gd@C82[C(COOH)2]6, in buffer solution, were found to be 18.20 and 11.08 mM(-1) s(-1) at concentration range between 0.001-0.025 mM Gd, and to be 12.71 and 6.73 mM(-1) s(-1) between 0.050-0.200 mM Gd, respectively. The results showed that the measured relaxivities for malonate derivatives of Gd@C82 were dependent on the concentration of these solutions and the number of hydrophilic carboxyl groups appended on the surface of the Gd@C82 cage. [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Process

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[PMID]: 23421977 [Au] Autor: Wan J; Zhao S; Cheng H; Lu M; Jiang S; Yin G; Gao X; Yang Y [Ad] Address: Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China. [Ti] Title: Varied distributions of late gadolinium enhancement found among patients meeting cardiovascular magnetic resonance criteria for isolated left ventricular non-compaction. [So] Source: J Cardiovasc Magn Reson;15:20, 2013. [Is] ISSN: 1532-429X [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: BACKGROUND: Late gadolinium enhancement (LGE) is identified frequently in LVNC. However, the features of this findings are limited. The purpose of the present study was to describe the frequency and distribution of LGE in patients meeting criteria for left ventricular non-compaction (LVNC), as assessed by cardiovascular magnetic resonance (CMR). METHODS: Forty-seven patients (37 males and 10 females; mean age, 39 ± 18 years) considered to meet standard CMR criteria for LVNC were studied. The LGE images were obtained 15 ± 5 min after the injection of 0.2 mmol/kg of gadolinium-DTPA using an inversion-recovery sequence, and analyzed using a 17-segment model. RESULTS: Mean number of non-compacted segments per patient was 7.4 ± 2.5 and the NC:C was 3.2 ± 0.7. Non-compaction was most commonly noted in the apical segments in all patients. LGE was present in 19 of the 47 patients (40%), and most often located in the ventricular septum. The distribution of LGE was subendocardial (n = 5; 6%), mid-myocardial (n = 61; 68%), subepicardial (n = 10; 11%), and transmural (n = 14; 15%) in total of 90 LGE (+) segments. CONCLUSIONS: In patients considered to meet criteria for LVNC, LGE distributions visible were strikingly heterogeneous with appearances potentially attributable to three or more distinct cardiomyopathic processes. This may be in keeping with previous suggestions that the criteria may be of low specificity. Further work is needed to determine whether conditions such as dilated cardiomyopathy, previous myocardidtis or ischaemic heart disease increase the apparent depth of non-compact relative to compact myocardium. [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Entry month: 1303 [Js] Journal subset: IM [St] Status: In-Process [do] DOI: 10.1186/1532-429X-15-20

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[PMID]: 23537966 [Au] Autor: Chakrabarti AK; Feeney K; Abueg C; Brown DA; Czyz E; Tendera M; Janosi A; Giugliano RP; Kloner RA; Weaver WD; Bode C; Godlewski J; Merkely B; Gibson CM [Ad] Address: PERFUSE Study Group, Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical, Harvard Medical School, Boston, MA 02215, USA. [Ti] Title: Rationale and design of the EMBRACE STEMI study: a phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of intravenous Bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary intervention and stenting for ST-segment elevation myocardial infarction. [So] Source: Am Heart J;165(4):509-514.e7, 2013 Apr. [Is] ISSN: 1097-6744 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: BACKGROUND: Although significant efforts have been made to improve ST-segment elevation myocardial infarction (STEMI) outcomes by reducing symptom-onset-to-reperfusion times, strategies to decrease the clinical impact of ischemic reperfusion injury have demonstrated limited success. Bendavia, an intravenously administered mitochondrial targeting peptide, has been shown to reduce myocardial infarct size and attenuate coronary no-reflow in experimental modelswhen given before reperfusion. DESIGN: The EMBRACE STEMI study is a phase 2a, randomized, double-blind, placebo-controlled trial enrolling 300 patients with a first-time anterior STEMI and an occluded proximal or mid-left anterior descending artery undergoing primary percutaneous coronary intervention (PCI) within 4 hours of symptom onset. Patients will be randomized to receive either Bendavia at 0.05 mg/kg per hour or an identically appearing placebo administered as an intravenous infusion at 60 mL/h. The primary end point is infarct size measured by the area under the creatine kinase-MB enzyme curve calculated from measurements from the central clinical chemistry laboratory obtained over the initial 72 hours after the primary PCI procedure, and the major secondary end point is infarct size calculated by the volume of infarcted myocardium (late contrast gadolinium enhancement) on the day 4±1 cardiac magnetic resonance imaging. SUMMARY: EMBRACE-STEMI is testing the hypothesis that Bendavia, in conjunction with standard-of-care therapy, is superior to placebo for the reduction of myocardial infarction size among patients with first time, acute, anterior wall STEMI who undergo successful reperfusion with primary PCI and stenting. [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Entry month: 1303 [Js] Journal subset: AIM; IM [Cl] Clinical Trial: ClinicalTrial [St] Status: In-Process

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[PMID]: 23469825 [Au] Autor: Ogieglo JM; Katelnikovas A; Zych A; Jüstel T; Meijerink A; Ronda CR [Ad] Address: CMI, Debye Institute for Nanomaterials Science, Utrecht University, P.O. Box 80 000, 3508 TA Utrecht, The Netherlands. [Ti] Title: Luminescence and luminescence quenching in Gd3(Ga,Al)5O12 scintillators doped with Ce3+. [So] Source: J Phys Chem A;117(12):2479-84, 2013 Mar 28. [Is] ISSN: 1520-5215 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: The optical properties of gadolinium gallium aluminum garnet, Gd3(Ga,Al)5O12, doped with Ce(3+) are investigated as a function of the Ga/Al ratio, aimed at an improved understanding of the energy flow and luminescence quenching in these materials. A decrease of both the crystal field strength and band gap with increasing content of Ga(3+) is observed and explained by the geometrical influence of Ga(3+) on the crystal field splitting of the 5d level in line with theoretical work of Muñoz-García et al. ( uñoz-García, A. B.; Seijo, L. Phys. Rev. B 2010, 82, 184118 ). Thermal quenching results in shorter decay times as well as reduced emission intensities for all samples in the temperature range from 100 to 500 K. An activation energy for emission quenching is calculated from the data. The band gap of the host is measured upon Ga substitution and the decrease in band gap is related to Ga(3+) substitution into tetrahedral sites after all octahedral sites are occupied in the garnet material. Based on the change in band gap and crystal field splitting, band diagrams can be constructed explaining the low thermal quenching temperatures in the samples with high Ga content. The highest luminescence intensity is found for Gd3(Ga,Al)5O12 with 40% of Al(3+) replaced by Ga(3+). [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1303 [Js] Journal subset: IM [St] Status: In-Process [do] DOI: 10.1021/jp309572p

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[PMID]: 23395689 [Au] Autor: Howell M; Mallela J; Wang C; Ravi S; Dixit S; Garapati U; Mohapatra S [Ad] Address: Molecular Medicine Department, Morsani College of Medicine, University of South Florida, Box MDC7, 12901 Bruce B Downs, Tampa, FL 33612, United States. [Ti] Title: Manganese-loaded lipid-micellar theranostics for simultaneous drug and gene delivery to lungs. [So] Source: J Control Release;167(2):210-8, 2013 Apr 28. [Is] ISSN: 1873-4995 [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: Gadolinium (Gd) contrast agents are predominantly used for T(1) MR imaging. However, the high toxicity of Gd(3+) and potential side effects including nephrogenic systemic fibrosis have led to the search for alternative T(1) contrast agents. Since manganese (Mn) has paramagnetic properties with five unpaired electrons that permit high spin number, long electronic relaxation times, and labile water exchange, we evaluated Mn as a T(1) magnetic resonance imaging (MRI) contrast agent for lung imaging. Here we report on the design and synthesis of multifunctional lipid-micellar nanoparticles (LMNs) containing Mn oxide (M-LMNs) for MRI that can also be used for DNA and drug delivery. Oleic acid-coated MnO nanoparticles were encapsulated in micelles composed of polyethylene glycol (PEG-2000), phosphatidylethanolamine (PE), DC-cholesterol, and dioleoyl-phosphatidylethanolamine (DOPE). The particles are taken up in vitro by human embryonic kidney (HEK293), Lewis lung carcinoma (LLC1), and A549 cells and are devoid of cytotoxicity. When administered to mice intranasally, they preferentially accumulate in the lungs. In vitro phantom and ex vivo lung MRI results confirmed that M-LMNs are able to enhance T(1) MRI contrast. M-LMNs loaded with plasmid DNA and/or doxorubicin are efficiently taken up by HEK293 cells in vitro and by target cells in vivo. Taken together, these results demonstrate that M-LMNs are capable of simultaneously providing MRI contrast and DNA and/or drug delivery to target cells in the lung and therefore may prove useful as a lung theranostic, especially for lung cancers. [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Em] Entry month: 1303 [Js] Journal subset: IM [St] Status: In-Process

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[PMID]: 23534587 [Au] Autor: Herédia V; Altun E; Ramalho M; de Campos R; Azevedo R; Pamuklar E; Semelka RC [Ad] Address: Department of Radiology, University of North Carolina, Chapel Hill, NC, USA. [Ti] Title: MRI of pregnant patients for suspected pulmonary embolism: steady-state free precession vs postgadolinium 3D-GRE. [So] Source: Acta Med Port;25(6):359-67, 2012 Nov-Dec. [Is] ISSN: 1646-0758 [Cp] Country of publication: Portugal [La] Language: eng [Ab] Abstract: INTRODUCTION: Pulmonary embolism is a leading cause of maternal mortality in the developed world. Ventilation-perfusion scintigraphy and Computer tomography cause ionizing radiation exposure. Gadolinium-enhanced magnetic resonance imaging is generally not indicated in pregnant patients. MRI using motion resistant techniques that do not use intravenous contrast material, such as balanced steady-state free precession may be a better approach in pregnant patients. PURPOSE: To describe the preliminary findings of the use of SSFP for the evaluation of pregnant patients with suspected PE, and to compare with a young women population evaluated with postgadolinium 3D-gradient echo sequences for the same intention. MATERIALS AND METHODS: Radiology database was searched for two groups of subjects who underwent chest MRI at 1.5T for suspected PE, between January, 2007 and June, 2010: pregnant patients with MRI including balanced SSFP (group A) and females younger than 45 years old including a T1-weighted postgadolinium 3D-GRE (group B) sequence. The final study population consisted of 21 subjects. Blind and independent evaluation of MR images was performed for image quality of the pulmonary arterial system, PE and other chest findings. Data was subject to statistical analysis. RESULTS: Good image quality was observed in all central and lobar arteries on both groups and in 90% (group A) and at least 83.3% (group B) of the segmental arteries. There was no significant difference between groups A and B for image quality of central and lobar pulmonary arteries (p > 0.05). CONCLUSION: SSFP can visualize central, lobar and segmental pulmonary arteries with sufficient image quality in pregnant patients, comparable to 3D-GRE. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1303 [Js] Journal subset: IM [St] Status: In-Process

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