Database : MEDLINE
Search on : granulocytes [Words]
References found : 31475 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 3148 go to page                         

  1 / 31475 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29444436
[Au] Autor:Liu Y; Liu F; Cao Y; Xu H; Wu Y; Wu S; Liu D; Zhao Y; Songyang Z; Ma W
[Ad] Address:Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Oncology in South China, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China.
[Ti] Title:Shwachman-Diamond Syndrome Protein SBDS Maintains Human Telomeres by Regulating Telomerase Recruitment.
[So] Source:Cell Rep;22(7):1849-1860, 2018 Feb 13.
[Is] ISSN:2211-1247
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Although SBDS patients were reported to have shorter telomere length in granulocytes, the underlying mechanism is still unclear. Here we provide data to elucidate the role of SBDS in telomere protection. We demonstrate that SBDS deficiency leads to telomere shortening. We found that overexpression of disease-associated SBDS mutants or knockdown of SBDS hampered the recruitment of telomerase onto telomeres, while the overall reverse transcriptase activity of telomerase remained unaffected. Moreover, we show that SBDS could specifically bind to TPP1 during the S phase of cell cycle, likely functioning as a stabilizer for TPP1-telomerase interaction. Our findings suggest that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review

  2 / 31475 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29428349
[Au] Autor:Li J; Bach A; Crawford RB; Phadnis-Moghe AS; Chen W; D'Ingillo S; Kovalova N; Suarez-Martinez JE; Zhou J; Kaplan BLF; Kaminski NE
[Ad] Address:Institute for Integrative Toxicology, Michigan State University, Lansing East, MI, 48824, United States.
[Ti] Title:CLARITY-BPA: Effects of chronic Bisphenol A exposure on the immune system: Part 1 - Quantification of the relative number and proportion of leukocyte populations in the spleen and thymus.
[So] Source:Toxicology;396-397:46-53, 2018 Feb 08.
[Is] ISSN:1879-3185
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Bisphenol A (BPA) is extensively used in manufacturing of a broad range of consumer products worldwide. Due to its widespread use, human exposure to BPA is virtually ubiquitous. Broad human exposure coupled with a large scientific literature describing estrogenic activity of BPA in animals has raised public health concerns. To comprehensively evaluate the health effects of BPA exposure, a chronic toxicity study using a wide-range of BPA doses (2.5-25000 µg/kg bw/day) was conducted jointly by the NTP, thirteen NIEHS-supported grantees, and the FDA, which is called the Consortium Linking Academic and Regulatory Insights on Toxicity of BPA (CLARITY-BPA). As a participant in the CLARITY-BPA project, the objective of the current study was to evaluate the effects of chronic BPA exposure in Sprague-Dawley rats on the relative number and proportion of defined leukocyte populations in the spleen and the thymus. Toward this end, lymphoid tissues from a total of 641 rats were assayed after being continuously dosed with BPA or controls for up to one year. To comprehensively evaluate the effects of BPA on leukocyte compositions, extensive endpoints that cover major populations of leukocytes were assessed, including B cells, T cells, NK cells, granulocytes, monocytes, macrophages and dendritic cells. In total, of the 530 measurements in BPA-treated rats, 10 measurements were statistically different from vehicle controls and were mainly associated with either the macrophage or dendritic cell populations. Most, if not all, of these alterations were found to be transient with no persistent trend over the one-year time period. In addition, the observed BPA-associated alterations were mostly moderate in magnitude and not dose-dependent. Due to the aforementioned, it is unlikely that the observed BPA-mediated changes alone would adversely affect immune competence.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:Publisher

  3 / 31475 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29506719
[Au] Autor:Geovanini GR; Wang R; Weng J; Tracy R; Jenny NS; Goldberger AL; Costa MD; Liu Y; Libby P; Redline S
[Ad] Address:Department of Medicine, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: ggeovanini@hsph.harvard.edu.
[Ti] Title:Elevations in neutrophils with obstructive sleep apnea: The Multi-Ethnic Study of Atherosclerosis (MESA).
[So] Source:Int J Cardiol;257:318-323, 2018 Apr 15.
[Is] ISSN:1874-1754
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Obstructive sleep apnea (OSA) associates with increased risk of cardiovascular diseases (CVD). Immune abnormalities and surges in sympathetic activity accompany OSA and CVD. We hypothesized that OSA associates with leukocytosis partially by abnormalities in autonomic nervous system (ANS) function that would suggest a pathway linking OSA and CVD. METHODS: Participants from the Multi-Ethnic Study of Atherosclerosis (MESA), a prospective cohort of individuals initially without overt CVD, underwent polysomnography and assays for white blood cells (WBC) and subsets. Heart rate (HR) and heart rate variability (HRV), indirect measurements of ANS, were obtained from overnight electrocardiography. A formal statistical mediation analysis tested the indirect effect that mean HR and HRV measures contribute to associations between OSA and leukocytosis. RESULTS: The analytical sample consisted of 1298 participants (54% female), ages 54-93years, 14% with severe OSA (apnea-hypopnea-index, AHI≥30). Severe OSA associated with a higher prevalence of obesity, diabetes, and increased levels of WBC total and subsets. Neutrophil count associated with severe OSA after adjusting for confounders (p=0.017). Mean HR positively associated with OSA indices and neutrophils. A mediation analysis revealed an "indirect" effect of mean HR that explained an estimated 11% of the association between AHI and neutrophils. Overnight hypoxia also associated with neutrophil count (p=0.009), and mean HR explained 14% of the association between neutrophils and hypoxia. CONCLUSIONS: In the MESA cohort, OSA measures associate with elevated neutrophil counts and increases in overnight mean HR. These data link innate immune dysregulation with OSA and provide a potential pathophysiologic pathway between CVD and OSA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review

  4 / 31475 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29431944
[Au] Autor:Ilinykh MV; Serebryakov PV; Antoshina LI
[Ti] Title:[Responsiveness of peripheral blood neutrophils under exposure to industrial aerosols].
[So] Source:Gig Sanit;95(11):1052-5, 2016.
[Is] ISSN:0016-9900
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:There was made an evaluation of the functional state of peripheral blood neutrophils in 230 workers with dustbreathing risks (mine, metallurgical and machine-building works). There was noted the change in the responsiveness of neutrophils in dependence on both composition and the intensity of the exposure of industrial aerosols to the human body. There was followed the relation between the pathology of the respiratory system with the biochemical changes of granulocytes. These data can be used for the assessment of the nonspecific body resistance in the development of dust lung diseases.
[Mh] MeSH terms primary: Aerosols
Air Pollutants, Occupational
Neutrophil Activation/immunology
Occupational Diseases
Occupational Exposure
[Mh] MeSH terms secundary: Adaptation, Physiological/immunology
Adult
Aerosols/adverse effects
Aerosols/analysis
Air Pollutants, Occupational/adverse effects
Air Pollutants, Occupational/analysis
Dust/analysis
Dust/prevention & control
Humans
Inhalation Exposure/adverse effects
Inhalation Exposure/analysis
Inhalation Exposure/prevention & control
Male
Middle Aged
Neutrophil Activation/drug effects
Neutrophils/immunology
Neutrophils/pathology
Occupational Diseases/diagnosis
Occupational Diseases/etiology
Occupational Diseases/immunology
Occupational Diseases/prevention & control
Occupational Exposure/adverse effects
Occupational Exposure/analysis
Occupational Exposure/prevention & control
Occupational Health
Russia/epidemiology
Statistics as Topic
Time
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Aerosols); 0 (Air Pollutants, Occupational); 0 (Dust)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180213
[St] Status:MEDLINE

  5 / 31475 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29520557
[Au] Autor:Liu YL; Zhang LD; Ma TM; Song ST; Liu HT; Wang X; Li N; Yang C; Yu S
[Ad] Address:Department of Acupuncture and Massage College, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Shenyang, Liaoning, 110847, People's Republic of China.
[Ti] Title:Feishu Acupuncture Inhibits Acetylcholine Synthesis and Restores Muscarinic Acetylcholine Receptor M2 Expression in the Lung When Treating Allergic Asthma.
[So] Source:Inflammation;, 2018 Mar 08.
[Is] ISSN:1573-2576
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Acupuncture was proven beneficial in treating allergic inflammation. We aimed to explore the regulation underlying the effects of acupuncture on Feishu, an acupoint most commonly used in the acupuncture therapy for respiratory diseases, with respect to the system of sympathetic nerve neurotransmitter acetylcholine (Ach). Male Wistar rats were randomly grouping. No treatment was taken in the normal group. Allergic asthma was induced using ovalbumin on the model, Feishu acupuncture, and sham acupuncture groups; then control or acupuncture treatment lasting for 3 weeks was performed. Bronchoalveolar lavage fluid (BALF) from the four groups was examined. And pulmonary tissues were subjected to histological analysis with H&E staining; besides, immunofluorescent staining, quantitative PCR, and western blot were used to detect synthetase (ChAT) and Ach hydrolase (AchE), and its muscarinic receptors (mAchRs) M1-M3. There was inflammatory infiltration in the lung upon allergic asthma, which was alleviated by the Feishu acupuncture. The eosinophilic granulocytes, neutrophils, and lymphocytes in BALF from the Feishu acupuncture group were all significantly decreased compared with those of the model and sham acupuncture groups. The specific acupuncture on Feishu upon allergic asthma put down the pulmonary expression of ChAT, repaired at the level of gene expression the pulmonary expression of mAchR M1, and restored the pulmonary expression of mAchR M2 (especially in the bronchiolar epithelium) which has a role in inhibiting Ach release; while sham acupuncture had no effect. These results confirmed the therapeutic effects of Feishu acupuncture on allergic asthma, suggesting that the mechanisms may involve suppression of the Ach signal both from its synthesis and during its release.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1007/s10753-017-0726-y

  6 / 31475 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29519972
[Au] Autor:Koray M; Atalay B; Akgul S; Oguz FS; Mumcu G; Saruhanoglu A
[Ad] Address:Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Istanbul University, Capa, Fatih, Istanbul, Turkey.
[Ti] Title:Relationship between salivary calprotectin levels and recurrent aphthous stomatitis: A preliminary study.
[So] Source:Niger J Clin Pract;21(3):271-275, 2018 Mar.
[Is] ISSN:1119-3077
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Aim: Recurrent aphthous stomatitis (RAS) is an inflammatory condition of the oral mucosa. The etiology of RAS remains unclear. Calprotectin is a major cytoplasmic protein contained in granulocytes, monocytes/macrophages and epithelial cells, and its level is increased body fluids in some inflammatory diseases. The aim is to determine the relationship between salivary calprotectin and RAS. Material and Methods: In the cross-sectional study, 67 patients with active lesions of RAS (F/M: 43/24, mean age: 30.27 ± 9.14 years) and 42 healthy controls (HC, F/M: 30/12, 30.54 ± 9.49 years) were included. Calprotectin levels were evaluated in unstimulated whole saliva samples by using the ELISA method in both groups. Results: Salivary calprotectin levels were significantly higher in RAS group (23.72 ± 4.28 mg/L) compared to the HC group (21.59 ± 4.27 mg/L) (P = 0.013). No significant relationship was found between calprotectin levels and age or gender in both groups (P >0.05). Conclusion: RAS is a very common inflammatory ulcerative condition of the oral cavity and its etiology is uncertain. Regarded as an inflammatory mechanism, releasing a high level of calprotectin in saliva has been suggested that it may play a role in pathogenesis of RAS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.4103/njcp.njcp_23_17

  7 / 31475 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29427599
[Au] Autor:Zhu L; Tang X; Xing J; Sheng X; Zhan W
[Ad] Address:Laboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, Qingdao 266003, China.
[Ti] Title:Differential proteome of haemocyte subpopulations responded to white spot syndrome virus infection in Chinese shrimp Fenneropenaeus chinensis.
[So] Source:Dev Comp Immunol;84:82-93, 2018 Feb 07.
[Is] ISSN:1879-0089
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In our previous study, the differentially expressed proteins have been identified by proteomic analysis in total haemocytes of shrimp (Fenneropenaeus chinensis) after white spot syndrome virus (WSSV) infection. To further investigate the differential response of haemocyte subpopulations to WSSV infection, granulocytes and hyalinocytes were separated from healthy and WSSV-infected shrimp by immunomagnetic bead (IMB) method, respectively. Then two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) were used to analyze the differentially expressed proteins in haemocyte subpopulations between healthy and WSSV-infected shrimp. The results of flow cytometry (FCM) showed that about 98% of granulocytes and about 96% of hyalinocytes in purity were obtained. Quantitative intensity analysis revealed that 26 protein spots in granulocytes and 24 spots in hyalinocytes were significantly changed post WSSV infection. Among them, 24 proteins in granulocytes and 23 proteins in hyalinocytes were identified by MS analysis, which could be divided into eight categories according to Gene Ontology. The identification of prophenoloxidase (proPO), proPO 2 and peroxiredoxin in WSSV-infected granulocytes was consistent with the facts that the proPO-activating system and peroxiredoxin were mainly existed in granulocytes. The phagocytosis of hyalinocytes seemed to be enhanced during the infection, because several proteins that involved in phagocytosis, including clathrin heavy chain, ADP ribosylation factor 4 and Alpha2 macroglobulin were up-regulated in hyalinocytes upon WSSV infection. Our results also reflected the vital biological significance of calcium ion binding proteins in granulocytes and ATPase/GTPase in hyalinocytes during WSSV infection. The data in this study verified the roles of granulocytes and hyalinocytes involved in WSSV infection, and differentially expressed proteins identified in granulocytes and hyalinocytes had a close correlation with their function characteristics.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher

  8 / 31475 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29427417
[Au] Autor:Hu L; Huang W; Bei L; Broglie L; Eklund EA
[Ad] Address:Northwestern University, Chicago, IL 60611.
[Ti] Title: Haploinsufficiency Rescues Emergency Granulopoiesis in Mice.
[So] Source:J Immunol;200(6):2129-2139, 2018 Mar 15.
[Is] ISSN:1550-6606
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Emergency (stress) granulopoiesis is an episodic process for the production of granulocytes in response to infectious challenge. We previously determined that Fanconi C, a component of the Fanconi DNA-repair pathway, is necessary for successful emergency granulopoiesis. Fanconi anemia results from mutation of any gene in this pathway and is characterized by bone marrow failure (BMF) in childhood and clonal progression in adolescence. Although murine Fanconi anemia models exhibit relatively normal steady-state hematopoiesis, mice are unable to mount an emergency granulopoiesis response. Instead, these mice develop BMF and die during repeated unsuccessful emergency granulopoiesis attempts. In mice, BMF is associated with extensive apoptosis of hematopoietic stem and progenitor cells through an undefined mechanism. In this study, we find that haploinsufficiency completely rescues emergency granulopoiesis in mice and protects them from BMF during repeated emergency granulopoiesis episodes. Instead, such recurrent challenges accelerated clonal progression in mice. In mice, BMF during multiple emergency granulopoiesis attempts was associated with increased ataxia telangiectasia and Rad3-related protein (Atr) and p53 activation with each attempt. In contrast, we found progressive attenuation of expression and activity of Atr, and consequent p53 activation and apoptosis, in the bone marrow of mice during this process. Therefore, activation of Atr-with consequent Fanconi-mediated DNA repair or p53-dependent apoptosis-is an essential component of emergency granulopoiesis and it protects the bone marrow from genotoxic stress during this process.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.4049/jimmunol.1700931

  9 / 31475 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28462680
[Au] Autor:Ismail AQT
[Ad] Address:a Royal Stoke University Hospital , Newcastle Rd , Stoke-on-Trent , UK.
[Ti] Title:Does placental MDSC-mediated modulation of arginine levels help protect the foetus from auxotrophic pathogens?
[So] Source:J Matern Fetal Neonatal Med;31(12):1667-1669, 2018 Jun.
[Is] ISSN:1476-4954
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Myeloid-derived suppressor cells (MDSCs) are immunosuppressive precursors of dendritic cells, macrophages and granulocytes. MDSCs normally quickly differentiate, but have elevated levels in chronic infection and cancer, where they help tumours evade the immune system through induction of T-cell dysfunction. MDSC levels are also raised in pregnancy, and in the neonate. During pregnancy they may help to prevent maternal rejection of the semiallogenic foetus. In the immediate postnatal period they may aid in allowing tolerance of gut microbiological colonisation and non-pathological environmental antigens. MDSC immunosuppression involves reduction of arginine levels, which leads to downregulation of T-cell receptor (TCR) and cell proliferation. Arginine is also involved in replication, and virulence of a variety of viruses and bacteria, including Hepatitis D, HIV-1, Herpes simplex, Adenovirus, Staphylococci, Neisseria gonorrhoea, Escherichia coli, and Streptococci. Given the above it could be hypothesised that MDSC-mediated reduction in levels during pregnancy and the perinatal period is not just a by-product of T-cell immunosuppression, but potentially a primitive part of the innate immune system. Increased arginase activity would therefore serve a dual purpose, inhibiting the adaptive immune system whilst also providing a degree of protection against infection by arginine auxotrophic pathogens.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1080/14767058.2017.1319935

  10 / 31475 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29516693
[Au] Autor:Zhang CR; Deng JL; Zhu WN; Miao MX; Shen WW; Cao SJ; Tang Y
[Ad] Address:Department of Acupuncture and Moxibustion, the Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210001, China.
[Ti] Title:[Involvement of PI 3 K/Akt/mTOR Signaling in Protective Effects of Moxibustion for Premature Ovarian Failure in Rats].
[So] Source:Zhen Ci Yan Jiu;43(2):75-9, 2018 Feb 25.
[Is] ISSN:1000-0607
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To study the protective effect of moxibustion for tripterygium-induced premature ovarian failure (POF) and its underlying mechanisms in rats. METHODS: Forty-five female SD rats were randomly divided into normal control, POF model and moxibustion groups ( =15/group). The POF model was induced by intragastric administration of Triptolide (40 mg/kg), once daily for 6 weeks. From the 4 week after modeling, moxibustion was given at "Guanyuan" (CV 4) and bilateral "Sanyinjiao" (SP 6) for 10 min, once daily for 3 weeks. Pathological changes of ovary tissues were determined by hematoxylin-eosin (HE) staining. The serum estradiol (E ), luteinizing hormone (LH), follicle-stimulating hormone (FSH), interleukin-6 (IL-6) and interleukin-1 ß (IL-1 ß) contents were measured by enzyme-linked immunosorbent assay (ELISA). The expression levels of phosphatidyl inositol 3- kinase (PI 3 K), protein kinase B (Akt) and mammalian target of rapamycin (mTOR) proteins of the ovarian tissue were detected by Western blot. RESULTS: After modeling, HE staining showed that the numbers of ovarian follicles and follicular granulocytes and corpora luteum layers were decreased, and the number of corpora atretica was increased in the model group. The content of serum E was markedly decreased and those of serum LH, FSH, IL-6 and IL-1 ß were markedly increased in the model group ( <0.01), and the expression levels of ovarian p-PI 3 K, p-Akt and p-mTOR were markedly increased after modeling relevant to the control group ( <0.01). Following moxibustion, the pathological damage of ovarian tissue was improved, the contents of serum LH, FSH, IL-6, IL-1 ß, and the levels of p-PI 3 K, p-Akt and p-mTOR proteins in the ovarian tissue were significantly decreased ( <0.05, <0.01), and the content of serum E was markedly increased ( <0.05) in comparison with the model group. CONCLUSION: Moxibustion can improve POF in POF rats, which may be related to its actions in inhibiting PI 3 K/Akt/mTOR signaling, down-regulating serum IL-6, IL-1 ß, and regulating serum hormones.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.13702/j.1000-0607.170857


page 1 of 3148 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information