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[PMID]: 25118937
[Au] Autor:Ma J; Sun F; Li C; Zhang Y; Xiao W; Li Z; Pan Q; Zeng H; Xiao G; Yao K; Hong A; An J
[Ad] Address:1] Institute of Genetic Engineering, Jinan University, National Engineering Research Center of Genetic Medicine, Key Lab for Genetic Medicine of Guangdong Province, Guangzhou, People's Republic of China [2] Central Laboratory, Shanghai 10th People's Hospital of Tongji University, Shanghai, People's ...
[Ti] Title:Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma.
[So] Source:Cell Death Dis;5:e1377, 2014.
[Is] ISSN:2041-4889
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Nasopharyngeal carcinoma (NPC) is a major malignant tumor of the head and neck region in southern China. The understanding of its underlying etiology is essential for the development of novel effective therapies. We report for the first time that microRNA-940 (miR-940) significantly suppresses the proliferation of a variety of cancer cell lines, arrests cells cycle, induces caspase-3/7-dependent apoptosis and inhibits the formation of NPC xenograft tumors in mice. We further show that miR-940 directly binds to the 3'-untranslated regions of Nestin mRNA and promotes its degradation. Likewise, depletion of Nestin inhibits tumor cell proliferation, arrest cells at G2/M, induces apoptosis and suppresses xenograft tumor formation in vivo. These functions of miR-940 can be reversed by ectopic expression of Nestin, suggesting that miR-940 regulates cell proliferation and survival through Nestin. Notably, we observed reduced miR-940 and increased Nestin levels in NPC patient samples. Protein microarray revealed that knockdown of Nestin in 5-8F NPC cells alters the phosphorylation of proteins involved in the DNA damage response, suggesting a mechanism for the miR-940/Nestin axis. Consistently, depletion of Nestin induced spontaneous DNA damage accumulation, delayed the DNA damage repair process and increased the sensitivity to irradiation and the chemotherapeutic agent doxorubicin. Collectively, our findings indicate that Nestin, which is downregulated by miR-940, can promote tumorigenesis in NPC cells through involvement in the DNA damage response. The levels of microRNA-940 and Nestin may serve as indicators of cancer status and prognosis.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1038/cddis.2014.293

  2 / 333976 MEDLINE  
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[PMID]: 23931335
[Au] Autor:Serra-Guillén C; Llombart B; Nagore E; Requena C; Traves V; Llorca D; Kindem S; Alcalá R; Guillén C; Sanmartín O
[Ad] Address:Department of Dermatology, Instituto Valenciano de Oncología, Valencia.
[Ti] Title:Positive margins in excised dermatofibrosarcoma protuberans: a study of 58 cases treated with slow-Mohs surgery.
[So] Source:J Eur Acad Dermatol Venereol;28(8):1012-5, 2014 Aug.
[Is] ISSN:1468-3083
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is characterized by unpredictable subclinical extension, meaning that positive margins are frequently detected following conventional surgical excision. OBJECTIVE: To study the presence or absence of residual tumour in DFSP with positive margins after conventional surgery and identify possible predictors of residual tumour or clear margins following a single Mohs micrographic surgery (MMS) stage. METHODS: A retrospective study of patients with DFSP and positive margins following conventional excision referred for MMS was performed. We studied gender, age, tumour site, time from presentation to diagnosis, and affected margins. RESULTS: We studied 58 cases, 35 (60.3%) of which had histological evidence of residual tumour. Tumours of the head and neck were significantly associated with the persistence of tumour. A single MMS stage was sufficient to achieve clearance in the majority of cases (n = 46). All tumours with lateral involvement only were resolved with a single Mohs stage. CONCLUSIONS: DFSPs with positive margins after conventional surgical excision should undergo re-excision because the majority have histologic evidence of residual tumour. Re-excision with 1-cm margins beyond the scar could be an option in certain tumour sites, particularly when it is known which margins are involved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1111/jdv.12235

  3 / 333976 MEDLINE  
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[PMID]: 24681412
[Au] Autor:Mo KW; Vlantis A; Wong EW; Chiu TW
[Ad] Address:Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, Prince of Wales Hospital, Shatin, Hong Kong....
[Ti] Title:Double free flaps for reconstruction of complex/composite defects in head and neck surgery.
[So] Source:Hong Kong Med J;20(4):279-84, 2014 Aug.
[Is] ISSN:1024-2708
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:OBJECTIVE. To demonstrate the feasibility of double free flap surgery in head and neck reconstruction. DESIGN. Descriptive case series. SETTING. A university-affiliated hospital in Hong Kong. PATIENTS. Twelve patients with head and neck cancer (encountered over a 2.5-year period) who had reconstructive surgery with planned simultaneous double free flaps. RESULTS. The mean total operating time was 660 minutes and there were no flap failures. Postoperative stays ranged from 11 to 82 days; nine patients were discharged within 3 weeks and seven were able to maintain their weight with oral feeding. The survival rate up to 1 year was 64%. CONCLUSION. The use of double free flaps is an option worth considering for complex head and neck defects in carefully selected patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.12809/hkmj134113

  4 / 333976 MEDLINE  
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[PMID]: 25043884
[Au] Autor:Wang J; Yu R; Shete S
[Ad] Address:Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
[Ti] Title:X-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escape from X-inactivation.
[So] Source:Genet Epidemiol;38(6):483-93, 2014 Sep.
[Is] ISSN:1098-2272
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:X-chromosome inactivation (XCI) is the process in which one of the two copies of the X-chromosome in females is randomly inactivated to achieve the dosage compensation of X-linked genes between males and females. That is, 50% of the cells have one allele inactive and the other 50% of the cells have the other allele inactive. However, studies have shown that skewed or nonrandom XCI is a biological plausibility wherein more than 75% of cells have the same allele inactive. Also, some of the X-chromosome genes escape XCI, i.e., both alleles are active in all cells. Current statistical tests for X-chromosome association studies can either account for random XCI (e.g., Clayton's approach) or escape from XCI (e.g., PLINK software). Because the true XCI process is unknown and differs across different regions on the X-chromosome, we proposed a unified approach of maximizing likelihood ratio over all biological possibilities: random XCI, skewed XCI, and escape from XCI. A permutation-based procedure was developed to assess the significance of the approach. We conducted simulation studies to compare the performance of the proposed approach with Clayton's approach and PLINK regression. The results showed that the proposed approach has higher powers in the scenarios where XCI is skewed while losing some power in scenarios where XCI is random or XCI is escaped, with well-controlled type I errors. We also applied the approach to the X-chromosomal genetic association study of head and neck cancer.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1002/gepi.21814

  5 / 333976 MEDLINE  
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[PMID]: 24844768
[Au] Autor:Nund RL; Ward EC; Scarinci NA; Cartmill B; Kuipers P; Porceddu SV
[Ad] Address:Division of Speech Pathology, School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia, r.nund@uq.edu.au.
[Ti] Title:Carers' experiences of dysphagia in people treated for head and neck cancer: a qualitative study.
[So] Source:Dysphagia;29(4):450-8, 2014 Aug.
[Is] ISSN:1432-0460
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The implication of dysphagia for people treated nonsurgically for head and neck cancer (HNC) and its detrimental effects on functioning and quality of life has been well documented. To date, however, there has been a paucity of research on the effects of dysphagia following HNC on carers, independent of the consequences of a gastrostomy. The objective of this qualitative study was to report on the experiences of carers of people with dysphagia (non-gastrostomy dependent) following nonsurgical treatment for HNC and to identify the support needs of this group. A purposive, maximum-variation sampling technique was adopted to recruit 12 carers of people treated curatively for HNC since 2007. Each participated in an in-depth interview, detailing their experience of caring for someone with dysphagia and the associated impact on their life. Thematic analysis was adopted to search the transcripts for key phases and themes that emerged from the discussions. Analysis of the transcripts revealed four themes: (1) dysphagia disrupts daily life, (2) carers make adjustments to adapt to their partner's dysphagia, (3) the disconnect between carers' expectations and the reality of dysphagia, and (4) experiences of dysphagia-related services and informal supports. Carers generally felt ill-prepared for their role in dysphagia management. The qualitative methodology successfully described the impact of dysphagia on the everyday lives of carers, particularly in regard to meal preparation, social events, and family lifestyle. Clinicians should provide adequate and timely training and support to carers and view carers as copartners in dysphagia management.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s00455-014-9527-8

  6 / 333976 MEDLINE  
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[PMID]: 24641677
[Au] Autor:Kulkarni A; Quang P; Curry V; Keyes R; Zhou W; Cho H; Baffoe J; Török B; Stieglitz K
[Ad] Address:Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA, 02125, USA.
[Ti] Title:1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D.
[So] Source:Chem Biol Drug Des;84(3):270-81, 2014 Sep.
[Is] ISSN:1747-0285
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Phospholipase D enzymes cleave lipid substrates to produce phosphatidic acid, an important precursor for many essential cellular molecules. Phospholipase D is a target to modulate cancer-cell invasiveness. This study reports synthesis of a new class of phospholipase D inhibitors based on 1,3-disubstituted-4-amino-pyrazolopyrimidine core structure. These molecules were synthesized and used to perform initial screening for the inhibition of purified bacterial phospholipase D, which is highly homologous to the human PLD1 . Initially tested with the bacterial phospholipase D enzyme, then confirmed with the recombinant human PLD1 and PLD2 enzymes, the molecules presented here exhibited inhibition of phospholipase D activity (IC50 ) in the low-nanomolar to low-micromolar range with both monomeric substrate diC4 PC and phospholipid vesicles and micelles. The data strongly indicate that these inhibitory molecules directly block enzyme/vesicle substrate binding. Preliminary activity studies using recombinant human phospholipase Ds in in vivo cell assays measuring both transphosphatidylation and head-group cleavage indicate inhibition in the mid- to low-nanomolar range for these potent inhibitory novel molecules in a physiological environment.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1111/cbdd.12319

  7 / 333976 MEDLINE  
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[PMID]: 24296232
[Au] Autor:Benesch MG; Mannock DA; Lewis RN; McElhaney RN
[Ad] Address:Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2H7....
[Ti] Title:A DSC and FTIR spectroscopic study of the effects of the epimeric 4-cholesten-3-ols and 4-cholesten-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: comparison with their 5-cholesten analogues.
[So] Source:Chem Phys Lipids;177:71-90, 2014 Jan.
[Is] ISSN:1873-2941
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:We present the results of a comparative differential calorimetric and Fourier transform infrared spectroscopic study of the effect of cholesterol and five of its analogues on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes. These sterols/steroids differ in both the nature and stereochemistry of the polar head group at C3 (ßOH, αOH or C=O) and in the position of the double bond (C4-C5 in ring A or C5-C6 in ring B). In the three Δ(5) sterols/steroid series, the concentration of these compounds required to abolish the DPPC pretransition, inversely related to their relative ability to disorder gel state DPPC bilayers, decreases in the order ßOH>αOH>C=O and these differences in concentration are significant. However, in the Δ(4) series, these concentrations are more similar, regardless of polar head group nature or stereochemistry. Similarly, the residual enthalpy of the main phase transition of DPPC at 50 mol.% sterol/steroid, which is inversely related to the miscibility of these compounds in the DPPC bilayer, also increases in the order ßOH>αOH>C=O, but this effect is attenuated in the Δ(4) as opposed to the Δ(5) series. Both of these results indicate that the presence of a double bond at C4-C5 in ring A, as compared to a C5-C6 double bond in ring B, reduces the effect of variations in the structure of the polar group at C3 on the properties of the host DPPC bilayer. The movement of the double bond from C5 to C4 in the two sterol pairs results in a greater decrease in the temperature and enthalpy of both the pretransition and the main phase transition, whereas the opposite result is observed in the ketosteroid pair. Similarly, the ability of these compounds to order the DPPC hydrocarbon chains decreases in the order ßOH>αOH>C=O in both series of compounds, but in the two sterol pairs, hydrocarbon chain ordering is greater for the Δ(5) than the Δ(4) sterols, whereas the opposite is the case for the steroid pair. All of these results indicate that the typical effects of sterols/steroids in increasing the packing density and thermal stability of fluid lipid bilayers are optimal when an OH group rather than C=O group is present at C3, and that this OH group is more effective in the equatorial rather than the axial orientation. We can explain all of our sterol results by noting that the shift of the double bond from Δ(5) to Δ(4) introduces of a bend in ring A, which in turn destroys the coplanarity of the steroid fused ring system and reduces the goodness of sterol packing in the host DPPC bilayer. However, this conformational change should also occur in the ketosteroid pair, yet our experimental results indicate that the presence of the Δ(4) double bond is less disruptive than a double bond at Δ(5). We suggest that the presence of keto-enol tautomerism in the conjugated Δ(4) ketosteroid, but not in the nonconjugated Δ(5) compound, may provide additional H-bonding opportunities to adjacent DPPC molecules in the bilayer, which can overcome the unfavourable conformational change in ring A induced by the Δ(4) double bond.
[Mh] MeSH terms primary: 1,2-Dipalmitoylphosphatidylcholine/chemistry
Cell Membrane/drug effects
Cholestenones/chemistry
Cholestenones/pharmacology
Lipid Bilayers/chemistry
Spectroscopy, Fourier Transform Infrared
Temperature
[Mh] MeSH terms secundary: Absorption
Calorimetry, Differential Scanning
Cell Membrane/chemistry
Models, Molecular
Molecular Conformation
Phase Transition/drug effects
Stereoisomerism
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Cholestenones); 0 (Lipid Bilayers); 2644-64-6 (1,2-Dipalmitoylphosphatidylcholine); 601-57-0 (cholest-4-en-3-one)
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:140103
[St] Status:MEDLINE

  8 / 333976 MEDLINE  
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[PMID]: 24189590
[Au] Autor:Olshyk VN; Melsitova IV; Yurkova IL
[Ad] Address:Department of Chemistry, Belarusian State University, Minsk, Belarus.
[Ti] Title:Influence of lipids with hydroxyl-containing head groups on Fe2+ (Cu2+)/H2O2-mediated transformation of phospholipids in model membranes.
[So] Source:Chem Phys Lipids;177:1-7, 2014 Jan.
[Is] ISSN:1873-2941
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Under condition of ROS formation in lipid membranes, free radical reactions can proceed in both hydrophobic (peroxidation of lipids, POL) and polar (free radical fragmentation) parts of the bilayer. Free-radical fragmentation is typical for the lipids containing a hydroxyl group in ß-position with respect to an ester or amide bond. The present study has been undertaken to investigate free-radical transformations of phospholipids in model membranes containing lipids able to undergo fragmentation in their polar part. Liposomes from egg yolk lecithin containing saturated or monounsaturated glycero- and sphingolipids were subjected to the action of an HO* - generating system - Fe(2+)(Cu(2+))/H2O2/Asc, and the POL products were investigated. In parallel with this, the effects of monoacylglycerols and scavengers of reactive species on Fe(2+)(Cu(2+))/H2O2/Asc - mediated free-radical fragmentation of phosphatidylglycerols were studied. Hydroxyl-containing sphingolipids and glycerolipids, which undergo free-radical fragmentation under such conditions, manifested antioxidant properties in the model membranes. In the absence of HO groups in the lipid structure, the effect was either pro-oxidant or neutral. Monoacylglycerols slowed down the rate of both peroxidation in the hydrophobic part and free-radical fragmentation in the hydrophilic part of phospholipid membrane. Scavengers of reactive species inhibited the fragmentation of phosphatidylglycerol substantially. Thus, the ability of hydroxyl-containing lipids to undergo free-radical fragmentation in polar part apparently makes a substantial contribution to the mechanism of their protector action.
[Mh] MeSH terms primary: Copper/metabolism
Hydrogen Peroxide/metabolism
Hydroxyl Radical/metabolism
Iron/metabolism
Liposomes/metabolism
Phospholipids/chemistry
Phospholipids/metabolism
[Mh] MeSH terms secundary: Glycerophospholipids/metabolism
Lipid Peroxidation
Phosphatidylcholines/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Glycerophospholipids); 0 (Liposomes); 0 (Phosphatidylcholines); 0 (Phospholipids); 3352-57-6 (Hydroxyl Radical); 789U1901C5 (Copper); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron)
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:140103
[St] Status:MEDLINE

  9 / 333976 MEDLINE  
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[PMID]: 23866311
[Au] Autor:Standage M; Cumming SP; Gillison FB
[Ad] Address:Department for Health, University of Bath, Bath BA2 7AY, UK. M.Standage@bath.ac.uk
[Ti] Title:A cluster randomized controlled trial of the be the best you can be intervention: effects on the psychological and physical well-being of school children.
[So] Source:BMC Public Health;13:666, 2013.
[Is] ISSN:1471-2458
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The 'Be the Best You Can Be' (BtBYCB) program is a school-based intervention designed to foster positive physical, psychological, and social development via empowering young people to take ownership over their own personal development. The aim of this work is to determine the effectiveness of the BtBYCB program on (i) pupils' well-being, self-perceptions, self-esteem, aspirations, and learning strategies; and (ii) changes in modifiable health-risk behaviors (i.e., physical activity, diet, smoking, and alcohol consumption). METHODS/DESIGN: A two-arm cluster randomized controlled trial employing a wait-list control plus qualitative and mixed-method evaluations was used. Participants were school pupils from Years 7 and 8 (aged 11-13 years). Ten schools located in southwest England were randomly allocated to receive the BtBYCB intervention (n = 5 schools; 711 pupils) or a control condition (i.e., usual Personal, Social, and Health Education classes) (n = 5 schools; 622 pupils). Participants in the intervention condition received a program consisting of (i) a talk from an Olympian/Paralympian; (ii) 11 one-hour teacher-led PSHE classroom sessions in which pupils identified their aspirations, values, and interests and explored and acted on these via activities such as personal development planning, goal-setting, and peer-mentoring; and (iii) participated in a celebration event (e.g., second visit from Olympian/Paralympian and short individual presentations). Data were collected at baseline, post-intervention, and at 3-month follow-up.Focus groups (pupils and teachers) and individual interviews (headteachers) were conducted in the 5 intervention schools to (i) gain an in-depth understanding of mechanisms of change; (ii) explore ways in which the participants' motivation and engagement could be enhanced, and (iii) elicit user-feedback pertaining to how the program, content, and appeal could be improved.A mixed-method approach was used to describe and explain the differing experiences of particular groupings within and across the intervention schools; i.e., those for whom the program was effective, those that experienced little, if any change, and those for whom the program led to an inverse effect. DISCUSSION: The findings of this work will provide insight into the effectiveness of an innovative and child-centered program. The research will inform improvements to the BtBYCB program as well as other interventions targeting child/youth health and wellness. TRIAL REGISTRATION: The trial is registered as Current Controlled Trials ISRCTN99443695.
[Mh] MeSH terms primary: Early Intervention (Education)/methods
Health Promotion/methods
Health Status Indicators
Motor Skills/physiology
School Health Services/organization & administration
[Mh] MeSH terms secundary: Adolescent
Attitude to Health
Benchmarking
Child
Child Health Services
Cluster Analysis
England
Female
Humans
Male
Personal Autonomy
Self Concept
Socioeconomic Factors
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:130806
[St] Status:MEDLINE
[do] DOI:10.1186/1471-2458-13-666

  10 / 333976 MEDLINE  
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[PMID]: 25232517
[Au] Autor:Carpintero P; Caeiro JR; Carpintero R; Morales A; Silva S; Mesa M
[Ad] Address:Pedro Carpintero, Rocío Carpintero, Samuel Silva, Department of Orthopaedic, University Hospital Reina Sofía, 14004 Córdoba, Spain....
[Ti] Title:Complications of hip fractures: A review.
[So] Source:World J Orthop;5(4):402-11, 2014 Sep 18.
[Is] ISSN:2218-5836
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Nowadays, fracture surgery represents a big part of the orthopedic surgeon workload, and usually has associated major clinical and social cost implications. These fractures have several complications. Some of these are medical, and other related to the surgical treatment itself. Medical complications may affect around 20% of patients with hip fracture. Cognitive and neurological alterations, cardiopulmonary affections (alone or combined), venous thromboembolism, gastrointestinal tract bleeding, urinary tract complications, perioperative anemia, electrolytic and metabolic disorders, and pressure scars are the most important medical complications after hip surgery in terms of frequency, increase of length of stay and perioperative mortality. Complications arising from hip fracture surgery are fairly common, and vary depending on whether the fracture is intracapsular or extracapsular. The main problems in intracapsular fractures are biological: vascularization of the femoral head, and lack of periosteum -a major contributor to fracture healing- in the femoral neck. In extracapsular fractures, by contrast, the problem is mechanical, and relates to load-bearing. Early surgical fixation, the role of anti-thromboembolic and anti-infective prophylaxis, good pain control at the perioperative, detection and management of delirium, correct urinary tract management, avoidance of malnutrition, vitamin D supplementation, osteoporosis treatment and advancement of early mobilization to improve functional recovery and falls prevention are basic recommendations for an optimal maintenance of hip fractured patients.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1409
[Cu] Class update date: 140920
[Lr] Last revision date:140920
[Da] Date of entry for processing:140918
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5312/wjo.v5.i4.402


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