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[PMID]: 25957469
[Au] Autor:Chong JX; Burrage LC; Beck AE; Marvin CT; McMillin MJ; Shively KM; Harrell TM; Buckingham KJ; Bacino CA; Jain M; Alanay Y; Berry SA; Carey JC; Gibbs RA; Lee BH; Krakow D; Shendure J; Nickerson DA; Bamshad MJ; University of Washington Center for Mendelian Genomics
[Ad] Address:Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, WA 98195, USA....
[Ti] Title:Autosomal-Dominant Multiple Pterygium Syndrome Is Caused by Mutations in MYH3.
[So] Source:Am J Hum Genet;96(5):841-9, 2015 May 7.
[Is] ISSN:1537-6605
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Multiple pterygium syndrome (MPS) is a phenotypically and genetically heterogeneous group of rare Mendelian conditions characterized by multiple pterygia, scoliosis, and congenital contractures of the limbs. MPS typically segregates as an autosomal-recessive disorder, but rare instances of autosomal-dominant transmission have been reported. Whereas several mutations causing recessive MPS have been identified, the genetic basis of dominant MPS remains unknown. We identified four families affected by dominantly transmitted MPS characterized by pterygia, camptodactyly of the hands, vertebral fusions, and scoliosis. Exome sequencing identified predicted protein-altering mutations in embryonic myosin heavy chain (MYH3) in three families. MYH3 mutations underlie distal arthrogryposis types 1, 2A, and 2B, but all mutations reported to date occur in the head and neck domains. In contrast, two of the mutations found to cause MPS in this study occurred in the tail domain. The phenotypic overlap among persons with MPS, coupled with physical findings distinct from other conditions caused by mutations in MYH3, suggests that the developmental mechanism underlying MPS differs from that of other conditions and/or that certain functions of embryonic myosin might be perturbed by disruption of specific residues and/or domains. Moreover, the vertebral fusions in persons with MPS, coupled with evidence of MYH3 expression in bone, suggest that embryonic myosin plays a role in skeletal development.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Cu] Class update date: 150516
[Lr] Last revision date:150516
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 345705 MEDLINE  
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[PMID]: 25472556
[Au] Autor:Russell JA; Connor NP
[Ad] Address:University of Wisconsin School of Medicine and Public Health, Otolaryngology Head and Neck Surgery, Madison, WI, 53706, USA. russell@surgery.wisc.edu.
[Ti] Title:Effects of age and radiation treatment on function of extrinsic tongue muscles.
[So] Source:Radiat Oncol;9:254, 2014.
[Is] ISSN:1748-717X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Radiation treatment for head and neck cancer often results in difficulty swallowing. Muscle weakness and fibrosis have been identified clinically as possible etiologies for swallowing problems following radiation. Aging may compound the effects of radiation on swallowing because radiation-induced damage to muscles and other tissues critical for the oropharyngeal swallow is overlaid on a declining sensorimotor system. However, there have been no investigations of the manner in which aging and radiation treatment effects combine to impact tongue muscles, which are critical effectors of the oropharyngeal swallow. METHODS: Thirty-seven male Fisher 344/Brown Norway rats were divided into four groups; young adults (9 month old), old (32 months old), young radiation (9 months), and old radiation (32 months old). Two fractions of 11 Gy on consecutive days was delivered by external beam radiation to the ventral side of the rat's body over the anterior portion (20 X 30 mm area) of the anterior digastric muscle. Two-way analysis of variance (ANOVA) was used to examine the effects of age and radiation and their interaction on muscle contractile properties. Post-hoc testing was completed using Fisher's least significant differences (LSD). RESULTS: Radiation was associated with a significant decrease in tongue force production and reduced speed of tongue muscle contraction. However, radiation treatment did not lead to muscle atrophy and fibrosis formation in the GG muscle. Radiation treatment did not exacerbate atrophic changes observed with aging, or lead to additional fibrosis formation in the GG muscle from that observed in the other groups. CONCLUSIONS: The purpose of this research was to determine the effect of radiation on muscles of the tongue and to determine whether aging altered the extent of radiation injury to tongue muscles. Radiation was associated with a significant decrease in tongue force production and reduced speed of tongue muscle contraction, and the reduction in the speed of tongue muscle contraction was exacerbated in the aged-rat tongue. This work provides a foundation for future investigations of treatments for concurrent effects of aging and radiation on muscles of the tongue and swallowing.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 150516
[Lr] Last revision date:150516
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/s13014-014-0254-y

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[PMID]: 25892223
[Au] Autor:Ticau S; Friedman LJ; Ivica NA; Gelles J; Bell SP
[Ad] Address:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA....
[Ti] Title:Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading.
[So] Source:Cell;161(3):513-25, 2015 Apr 23.
[Is] ISSN:1097-4172
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Loading of the ring-shaped Mcm2-7 replicative helicase around DNA licenses eukaryotic origins of replication. During loading, Cdc6, Cdt1, and the origin-recognition complex (ORC) assemble two heterohexameric Mcm2-7 complexes into a head-to-head double hexamer that facilitates bidirectional replication initiation. Using multi-wavelength single-molecule fluorescence to monitor the events of helicase loading, we demonstrate that double-hexamer formation is the result of sequential loading of individual Mcm2-7 complexes. Loading of each Mcm2-7 molecule involves the ordered association and dissociation of distinct Cdc6 and Cdt1 proteins. In contrast, one ORC molecule directs loading of both helicases in each double hexamer. Based on single-molecule FRET, arrival of the second Mcm2-7 results in rapid double-hexamer formation that anticipates Cdc6 and Cdt1 release, suggesting that Mcm-Mcm interactions recruit the second helicase. Our findings reveal the complex protein dynamics that coordinate helicase loading and indicate that distinct mechanisms load the oppositely oriented helicases that are central to bidirectional replication initiation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 150516
[Lr] Last revision date:150516
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 25876685
[Au] Autor:Wang Y; Huang D; Shi J; Ma J; Zhao J; Li B; Xu X; Hu H; Zhou Y
[Ad] Address:Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
[Ti] Title:[Prognostic observation of 465 patients with retinoblastoma with optic nerve invasion].
[So] Source:Zhonghua Er Ke Za Zhi;53(2):109-13, 2015 Feb.
[Is] ISSN:0578-1310
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To observe the treatment and prognosis of optic nerve invasion in retinoblastoma (RB). METHOD: The children who had been diagnosed with unilateral RB and had received enucleation from January 2006 to December 2013 in our hospital were recruited. Tumor extension into the optic nerve were disclosed. Optic nerve involvement was classified into four grades according to the degree of invasion. Grade I is superficial invasion of the optic nerve head only, grade II is involvement up to and including the lamina cribrosa, grade III is involvement beyond the lamina cribrosa, and grade IV is involvement up to and including the surgical margin. Grade I and II are called invasion of the optic nerve before the sieve plate. Grade III and IV are called invasion of the optic nerve after the sieve plate. Other high-risk factors included extensive invasions of the choroid, sclera, anterior chamber, iris, and ciliary body. They were divided into two groups according to whether the merger of other high histopathologic risk factors. Treatment was delivered accordingly, and the prognosis of different degrees of optic nerve invasion was observed. The subjects were followed up for 6 months to 7 years (average: 43 months). RESULT: There were 465 subjects in this study, including 279 boys and 186 girls. The right eye was affected in 260 patients and the left eye in 205 patients. The average time from onset of symptoms to visit was 2.7 months (range 1 day-24 months). Twenty-five patients died, resulting in an overall survival rate of 94.6%. The mortality rate of patients with optic nerve involvement with grade I was 0.4%, grade II was 1.0%, grade III was 8.7% was and grade IV was 60.9%. Of the 338 with invasion of the optic nerve before the sieve plate, two died of recurrence, with a survival rates of 99.4% (336/338). Of the 127 patients who had invasion of the optic nerve after the sieve plate, twenty-three died of recurrence, with a survival rate of 81.9% (104/127) , the difference was statistically significant (χ² = 52.299, P = 0.000). A total of 379 patients did not have any other merged pathology high-risk factors, 8 died, the mortality rate was 2.1%. Of the 86 patients who had complicated with other high-risk factors, 17 died, the mortality rate was 19.8%, the difference was statistically significant (χ² = 42.955, P = 0.000). Of the 338 patients, 304 had invasion of the optic nerve before the sieve plate had not merged other pathology high-risk factors, none died, of the 34 patients who had complicated with other pathology high-risk factors, 2 had died, the mortality rate was 5.9%, the difference was statistically significant (P = 0.010). Of the 127 patients with invasion of the optic nerve after the sieve plate, 76 had not complicated with other pathological high-risk factors, 9 of whom had died, the mortality rate was 11.8%, 51 had complicated with other pathological high-risk factors, 14 of whom had died, the mortality rate was 27.5%, outcomes did significantly differ between the two subgroups (χ² = 5.014, P = 0.025). Cox multivariate analysis showed that invasion of the retrolaminar optic nerve, surgical margin of the optic nerve and sclera were influential factors of colorectal cancer. CONCLUSION: Patients with optic nerve invasion have an excellent outcome with current therapy. But for those whose resection margin was invaded, which has a high incidence of recurrence, chemotherapy is recommended for patients with postlaminar optic nerve involvement.
[Mh] MeSH terms primary: Optic Nerve Neoplasms/surgery
Retinoblastoma/surgery
[Mh] MeSH terms secundary: Child
Female
Humans
Male
Multivariate Analysis
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Optic Nerve Neoplasms/pathology
Prognosis
Retinoblastoma/pathology
Retrospective Studies
Survival Rate
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:150416
[St] Status:MEDLINE

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[PMID]: 24806334
[Au] Autor:Bell D; Saade R; Roberts D; Ow TJ; Kupferman M; DeMonte F; Hanna EY
[Ad] Address:Departments of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, diana.bell@mdanderson.org.
[Ti] Title:Prognostic utility of hyams histological grading and kadish-morita staging systems for esthesioneuroblastoma outcomes.
[So] Source:Head Neck Pathol;9(1):51-9, 2015 Mar.
[Is] ISSN:1936-0568
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Esthesioneuroblastoma (ENB) is derived from the specialized olfactory neuroepithelium. Hyams grading and Kadish staging have been used to prognosticate and to guide treatment decisions. In this study, we sought to validate the prognostic utility of these systems in a large ENB cohort. We retrospectively analyzed the records of patients with ENB who had been evaluated and treated at our institution. The association of grade and stage with prognostic outcome was assessed; the Kaplan-Meier estimator was used to generate 5-year OS and DFS curves. Out of 124 cases we identified, 121 were assessed for grading and 109 for staging. Review of the tissue samples revealed that 62 % of tumors were low grade (I/II) and 21 % were high grade (III/IV); 17 % of tumors were metastasis. The OS rate was 75 % at 5 years. The DFS was 60 % at 5 years. The OS was significantly worse for metastatic ENB (low-grade ENB vs metastatic ENB p = 0.01598); the DFS was significantly worse for high grade versus low grade ENB. Of the 109 cases that had been staged, 16 % were stage A, 33 % stage B, 43 % stage C, and 8 % stage D. In the A, B, and C groups, there were no significant differences between recurrence, distant metastasis, or 5-year survival rates. Statistical significance was not reached with the T, N, M and overall staging system. Age cutoff of 65 years reliably predicted OS. High grade of ENB was significantly associated with poor outcome, while advanced stage was not associated with poor outcome in this large cohort. Grading should certainly be considered in prognostication and treatment decisions for ENB.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 150516
[Lr] Last revision date:150516
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s12105-014-0547-3

  6 / 345705 MEDLINE  
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[PMID]: 25748405
[Au] Autor:Zhu M; Hu Q; Mai J; Lin Z
[Ad] Address:Department of Neonatology, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China....
[Ti] Title:[Analysis of pathogenic bacteria and drug resistance in neonatal purulent meningitis].
[So] Source:Zhonghua Er Ke Za Zhi;53(1):51-6, 2015 Jan.
[Is] ISSN:0578-1310
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To study the clinical characteristics, pathogenic bacteria, and antibiotics resistance of neonatal purulent meningitis in order to provide the guide for early diagnosis and appropriate treatment. METHOD: A retrospective review was performed and a total of 112 cases of neonatal purulent meningitis (male 64, female 58) were identified in the neonatal intensive care unit of Yuying Children's Hospital of Wenzhou Medical University seen from January 1, 2004 to December 31, 2013. The clinical information including pathogenic bacterial distribution, drug sensitivity, head imageology and therapeutic outcome were analyzed. Numeration data were shown in ratio and chi square test was applied for group comparison. RESULT: Among 112 cases, 46 were admitted from 2004 to 2008 and 66 from 2009 to 2013, 23 patients were preterm and 89 were term, 20 were early onset (occurring within 3 days of life) and 92 were late onset meningitis (occurring after 3 days of life). In 62 (55.4%) cases the pathogens were Gram-positive bacteria and in 50 (44.6%) were Gram-negative bacteria. The five most frequently isolated pathogens were Escherichia coli (32 cases, 28.6%), coagulase-negative staphylococcus (CNS, 20 cases, 17.9%), Streptococcus (18 cases, 16.1%, Streptococcus agalactiae 15 cases), Enterococci (13 cases, 11.6%), Staphylococcus aureus (9 cases, 8.0%). Comparison of pathogenic bacterial distribution between 2004-2008 and 2009-2013 showed that Gram-positive bacteria accounted for more than 50% in both period. Escherichia coli was the most common bacterium, followed by Streptococcus in last five years which was higher than the first five years (22.7% (15/66) vs. 6.5% (3/46), χ(2) = 5.278, P < 0.05). Klebsiella pneumoniae was more common isolate in preterm infants than in term infants (13.0% (3/23) vs. 1.1% (1/89), χ(2) = 7.540, P < 0.05). Streptococcus (most were Streptococcus agalactiae) was the most common bacteria in early onset meningitis and higher than those in late onset meningitis (35.0% (7/20) vs. 12.0% (11/92), χ(2) = 4.872, P < 0.05). Drug sensitivity tests showed that all the Gram-positive bacterial isolates were sensitive to linezolid. Staphylococci were resistant to penicillin, and most of them were resistant to erythromycin, oxacillin and cefazolin; 77.8%of CNS isolates were methicillin-resistant staphylococcus. No Streptococcus and Enterococcus faecalis was resistant to penicillin. None of enterococci was resistant to vancomycin. Among the Gram-negative bacterial isolates, more than 40% of Escherichia coli were resistant to commonly used cephalosporins such as cefuroxime, cefotaxime and ceftazidime, and all of them were sensitive to amikacin, cefoperazone sulbactam and imipenem. Isolates of Klebsiella pneumoniae were all resistant to ampicillin, cefuroxime, cefotaxime and ceftazidime, but none of them was resistant to piperacillin tazobactam and imipenem. Of the 112 patients, 69 were cured, 23 improved, 9 uncured and 11 died. There were 47 cases (42.0%) with poor prognosis, they had abnormal head imageology, severe complications and some cases died, 13 of 18 (72.2%) patients with meningitis caused by Streptococcus died. CONCLUSION: Escherichia coli, CNS and Streptococcus are the predominant pathogens responsible for neonatal purulent meningitis over the past ten years. There were increasing numbers of cases with Streptococcus meningitis which are more common in early onset meningitis with adverse outcome, therefore careful attention should be paid in clinic. Linezolid should be used as a new choice in intractable neonatal purulent meningitis cases caused by gram positive bacteria.
[Mh] MeSH terms primary: Anti-Bacterial Agents/pharmacology
Drug Resistance, Bacterial
Meningitis, Bacterial/microbiology
[Mh] MeSH terms secundary: Cefotaxime
Child
Female
Gram-Negative Bacteria
Gram-Positive Bacteria
Humans
Imipenem
Infant
Infant, Newborn
Infant, Newborn, Diseases
Intensive Care Units, Neonatal
Male
Meningitis, Bacterial/diagnosis
Meningitis, Bacterial/drug therapy
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Penicillins
Retrospective Studies
Staphylococcus
Staphylococcus aureus
Streptococcal Infections
Streptococcus
Streptococcus agalactiae
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Penicillins); 71OTZ9ZE0A (Imipenem); N2GI8B1GK7 (Cefotaxime)
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:150309
[St] Status:MEDLINE

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[PMID]: 25748400
[Au] Autor:Lin J; Liu P; Wang Y; Li H; Li X; Zhao J; Tang C; Du J; Jin H
[Ad] Address:Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
[Ti] Title:[Evaluation of the changes in heart rate during head-up test predicting the efficacy of oral rehydration salts on postural tachycardia syndrome in children].
[So] Source:Zhonghua Er Ke Za Zhi;53(1):25-9, 2015 Jan.
[Is] ISSN:0578-1310
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To predict the therapeutic efficacy of oral rehydration salts (ORS) by quantifying changes in heart rate during the head-up test (HUT) in children with postural tachycardia syndrome (POTS). METHOD: Fifty-four children from Peking University First Hospital during July 2005 to September 2013 were enrolled into POTS group. Twenty healthy children were enrolled in this study as the control group. Children with POTS were treated with ORS and successfully followed up. HUT test was done before and at the end of the treatment. POTS children were further divided into responding group and the non-responding group depending on if the symptom scores were reduced by 50% or greater after the treatment. The heart rate, systolic blood pressure (SBP) and diastolic blood pressure (DBP) changes during the HUT test were analyzed between the control group and the POTS patients. A receiver operating characteristic (ROC) curve was used to analyze the predictive value of the increase in heart rates (from the supine to upright) and the maximum upright heart rate in 10 minutes after ORS treatment. RESULT: POTS children were 6-17 (11.3 ± 3.0) years old and the control group children were 10-12 (11.0 ± 0.8) years old. The changes of the heart rate during the HUT was different between the POTS patients and the controls ((41 ± 10) vs. (20 ± 7) beats/min, t = -10.441, P = 0.000) . There was no significant difference between the two groups in the maximum upright heart rate in 10 minutes during the HUT ( (117 ± 12) vs. (114 ± 8) beats/min, t = -1.322, P = 0.192) . The symptom scores were reduced compared with those before treatment ((3.2 ± 1.8) vs. (5.7 ± 2.0), t = 10.958, P < 0.001) and the heart rate changes from supine to upright were decreased in 30 patients ((33 ± 11) vs. (41 ± 11) beats/min, t = 2.956, P = 0.006). Compared with the non-responding group (28 cases), the heart rate change during the HUT test was great in the responding group (26 cases) before treatment ((46 ± 10) vs. (37 ± 9) beats/min, t = -3.582, P = 0.001), and the maximum upright heart rate in 10 minutes was also high in the responding group ( (122 ± 12) vs. (113 ± 10) beats/min, t = -2.693, P = 0.010). The ROC curve showed that ORS for children with POTS would be predicted to be effective when the pre-treatment increase of heart rate was 41 beats/min (sensitivity 72% and specificity 70%), or when the maximum upright heart rate in 10 minutes was 123 beats/min before treatment (sensitivity 48% specificity 56%). When the two indices were used together, sensitivity was 84% and specificity was 56%. CONCLUSION: The changes in heart rate during the HUT was useful in predicting the response to ORS in children with POTS.
[Mh] MeSH terms primary: Fluid Therapy
Heart Rate
Postural Orthostatic Tachycardia Syndrome/therapy
[Mh] MeSH terms secundary: Blood Pressure
Child
Humans
Postural Orthostatic Tachycardia Syndrome/physiopathology
Predictive Value of Tests
ROC Curve
Salts
Sensitivity and Specificity
Treatment Outcome
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Name of substance:0 (Salts)
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:150309
[St] Status:MEDLINE

  8 / 345705 MEDLINE  
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[PMID]: 25524168
[Au] Autor:Newcomer ME; Brash AR
[Ad] Address:Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, 70803.
[Ti] Title:The structural basis for specificity in lipoxygenase catalysis.
[So] Source:Protein Sci;24(3):298-309, 2015 Mar.
[Is] ISSN:1469-896X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Many intriguing facets of lipoxygenase (LOX) catalysis are open to a detailed structural analysis. Polyunsaturated fatty acids with two to six double bonds are oxygenated precisely on a particular carbon, typically forming a single chiral fatty acid hydroperoxide product. Molecular oxygen is not bound or liganded during catalysis, yet it is directed precisely to one position and one stereo configuration on the reacting fatty acid. The transformations proceed upon exposure of substrate to enzyme in the presence of O2 (RH + O2 → ROOH), so it has proved challenging to capture the precise mode of substrate binding in the LOX active site. Beginning with crystal structures with bound inhibitors or surrogate substrates, and most recently arachidonic acid bound under anaerobic conditions, a picture is consolidating of catalysis in a U-shaped fatty acid binding channel in which individual LOX enzymes use distinct amino acids to control the head-to-tail orientation of the fatty acid and register of the selected pentadiene opposite the non-heme iron, suitably positioned for the initial stereoselective hydrogen abstraction and subsequent reaction with O2 . Drawing on the crystal structures available currently, this review features the roles of the N-terminal ß-barrel (C2-like, or PLAT domain) in substrate acquisition and sensitivity to cellular calcium, and the α-helical catalytic domain in fatty acid binding and reactions with O2 that produce hydroperoxide products with regio and stereospecificity. LOX structures combine to explain how similar enzymes with conserved catalytic machinery differ in product, but not substrate, specificities.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Entry month:1502
[Cu] Class update date: 150516
[Lr] Last revision date:150516
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1002/pro.2626

  9 / 345705 MEDLINE  
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[PMID]: 25622582
[Au] Autor:Yang X; Cai Q; Li H; Zhang Z; Chen T; Zhao L
[Ad] Address:Department of Pediatric Orthopedics, Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China....
[Ti] Title:[Results of surgical treatment for moderate or severe slipped capital femoral epiphysis through the approach of surgical hip dislocation].
[So] Source:Zhonghua Wai Ke Za Zhi;52(12):907-11, 2014 Dec 1.
[Is] ISSN:0529-5815
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To evaluate the results of surgical treatment for moderate or severe slipped capital femoral epiphysis (SCFE) using modified Dunn procedure through the approach of surgical hip dislocation at the interval of minimum 12 months follow-up. METHODS: From November 2011 to June 2013, 6 patients (7 hips) with SCFE were treated in department of pediatric orthopedics, Hospital Affiliated to Shanghai Jiaotong University School of Medicine, they all had trauma history. The patients were aged from 10-15 years, mean 13.6 years. The duration of symptoms ranged from 4 to 35 days, average 14.2 days. The degree of slip was averagely 45% (25%-55%). In 6 patients (except right side of 1 case was treated in situ with cannulated screws) were surgically treated using modified Dunn procedure through the approach of surgical hip dislocation. Postoperatively the brace was used for immobilizing the hip for 4 weeks, then 4 weeks of bed traction combined with rehabilitation program of hip joint activity. Eight weeks later, the gradual touchdown weight bearing was being allowed. RESULTS: The follow-up time ranged from 12 to 30 months, average 23.8 months. Six patients have been able to walk without crutches, no obvious limp. X-ray film showed femoral epiphysis line on the bit of good recovery, no appearance of avascular necrosis of the femoral head, joint space was normal. The Harris score of hip evaluation was 94.7 averagely, ranging 85-100, at the time of last follow-up. CONCLUSIONS: Application of surgical treatment for moderate or severe SCFE with open reduction through the approach of surgical hip dislocation is a valid alternative method. The femoral head epiphysis can be capable of restoring anatomy, at present no case occurred avascular necrosis, and patients are satisfied with the function of the hip joint.
[Mh] MeSH terms primary: Hip Dislocation/surgery
Slipped Capital Femoral Epiphyses
[Mh] MeSH terms secundary: Adolescent
Child
Femur
Femur Head
Femur Head Necrosis
Humans
Orthopedic Procedures
Treatment Outcome
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:150127
[St] Status:MEDLINE

  10 / 345705 MEDLINE  
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[PMID]: 25622581
[Au] Autor:Zhang J; Feng C; You H; Wang Y
[Ad] Address:Department of Pediatric Orthopaedics, Beijing Jishuitan Hospital, Beijing 100035, China. Email: a1391019@139.com....
[Ti] Title:[Results of following-up for 5-10 years of periacetabular osteotomy for acetabular dysplasia in adolescence].
[So] Source:Zhonghua Wai Ke Za Zhi;52(12):902-6, 2014 Dec 1.
[Is] ISSN:0529-5815
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To investigate the effects of periacetabular osteotomy (PAO) for developmental dysplasia of the hip in adolescent. METHODS: Twelve hips in 9 adolescent patients who underwent a Bernese periacetabular osteotomy for symptomatic or asymptomatic developmental dysplasia of the hip were analyzed. The average age of the patients at the time of surgery was 12.9 years(11-14 years). The Harris hip score and overall patient satisfaction with surgery were used to assess hip function and clinical results. Plain radiographs were used to assess the correction of the deformity and to observe progression of degenerative changes. RESULTS: The average duration of clinical follow-up was 88.5 (60-136) months. The mean Harris hip score increased from 89 ± 6 preoperatively to 97 ± 3 at the time of the most recent follow-up (t = -6.754, P = 0.000). All patients (12 hips) had an excellent clinical result. The lateral center-edge angle of Wiberg increased from 4° ± 13° preoperatively to 36° ± 7° at the time of the most recent follow-up (t = -11.677, P = 0.000). The acetabular roof obliquity decreased from 28° ± 10° preoperatively to 2° ± 8° at the time of the most recent follow-up (t = 9.038, P = 0.000). The acetabular-head index increased from 54% ± 11% preoperatively to 89% ± 13% at the time of the most recent follow-up (t = -11.137, P = 0.000). The hip center was translated medially. Improvement of cystic degeneration of the acetabulum were found in 4 hips. Remodeling of aspherical uncongruence were found in 5 cases. Crossing sign were found in 2 hips postoperatively without symptoms of impingement. CONCLUSIONS: PAO can provide comprehensive deformity correction and improve hip function in treatment of developmental dysplasia of the hip in adolescence. Some of the patients have improvement of cystic degeneration and remodeling of the hip.
[Mh] MeSH terms primary: Hip Dislocation/surgery
Osteotomy
[Mh] MeSH terms secundary: Acetabulum/pathology
Adolescent
Child, Preschool
Disease Progression
Hip Dislocation, Congenital
Humans
Postoperative Period
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:150127
[St] Status:MEDLINE


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