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[PMID]: 24132324 [Au] Autor: Cai C; Dehner LP; El-Mofty SK [Ad] Address: Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8118, St. Louis, MO, USA. [Ti] Title: In myofibroblastic sarcomas of the head and neck, mitotic activity and necrosis define grade: a case study and literature review. [So] Source: Virchows Arch;463(6):827-36, 2013 Dec. [Is] ISSN: 1432-2307 [Cp] Country of publication: Germany [La] Language: eng [Ab] Abstract: Low-grade myofibroblastic sarcoma (LGMFS) is considered a distinct entity in the World Health Organization classification of soft tissue neoplasms, defined as an atypical myofibroblastic proliferation with fibromatosis-like features and a predilection for the head and neck. A substantial subset of previously reported myofibroblastic sarcomas (MFS), particularly in the head and neck region, are associated with appreciable tumor-associated morbidity and mortality and should be differentiated from the more indolent LGMFS. However, no specific morphological criteria have been developed to define the entity of LGMFS. We have reviewed histological findings in conjunction with clinical follow-up information of previously reported MFS in the head and neck region in the English literature, with the addition of five new cases from our institution. We found that MFSs with 6 or more mitoses per 10 high power fields and/or presence of spontaneous necrosis were accompanied by a higher mortality rate that is statistically significant. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1311 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1007/s00428-013-1494-1

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[PMID]: 24274300 [Au] Autor: Carvalho LM; Carvalho F; de Lourdes Bastos M; Baptista P; Moreira N; Monforte AR; da Silva Ferreira AC; de Pinho PG [Ad] Address: REQUIMTE - Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, Porto University, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal. Electronic address: carvalho.lmf@gmail.com. [Ti] Title: Non-targeted and targeted analysis of wild toxic and edible mushrooms using gas chromatography-ion trap mass spectrometry. [So] Source: Talanta;118:292-303, 2014 Jan 15. [Is] ISSN: 1873-3573 [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: Mushrooms are known all over the world both due to the remarkable gastronomic value of some species and for severe intoxications mediated by other species that are frequently difficult to distinguish from the edible ones, by the common user. Therefore, it is important to develop strategies to discover molecules that can identify mushroom species. In the present work, two GC-MS methodologies were applied in the chemical characterization of 22 mushroom species (12 edible, 3 toxic and 7 potentially toxic) - a multi-target procedure to simultaneously determine amino acids (AA), fatty acids (FA) and sterols by previous derivatization procedure with MSTFA, and a Head Space-Solid Phase Microextraction method to determine volatiles. For both methods, two approaches to data analysis were used: (I) targeted analysis, to identify and quantify AA, FA sterols and volatiles; (II) untargeted analysis, including Principal Component Analysis and Partial Least Square Discriminant Analysis, in order to identify metabolites/metabolite pattern with potential species identification and/or differentiation. Multi-target experiment allowed the identification and quantification of twenty one primary metabolites (9 AA, 11 FA and 1 sterol). Furthermore, through untargeted data analysis, it was possible to identify a 5-carbon sugar alcohol structure molecule, which was tentatively identified as xylitol or adonitol, with potential to be a species-marker of the edible Suillus bovinus mushrooms. Volatile profiling studies resulted in the identification of the main volatiles in mushrooms. Untargeted analysis allowed the identification of 6 molecules that can be species- or genus-specific: one secondary metabolite specific to the edible species Lycoperdon perlatum, an ester of hexanoic acid, tentatively identified as allyl or vinyl caproate; and five other secondary metabolites, whose identification was not achieved, which were only detected in Lactarius aurantiacus specimens (edibility/toxicity unknown). [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1311 [Js] Journal subset: IM [St] Status: In-Data-Review

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[PMID]: 24274268 [Au] Autor: Meeravali NN; Madhavi K; Manjusha R; Kumar SJ [Ad] Address: National Center for Compositional Characterization of Materials, Bhabha Atomic Research Centre, ECIL Post, Hyderabad 500 062, India. [Ti] Title: Sequential extraction of platinum, cisplatin and carboplatin from environmental samples and pre-concentration/separation using vesicular coacervative extraction and determination by continuum source ETAAS. [So] Source: Talanta;118:37-44, 2014 Jan 15. [Is] ISSN: 1873-3573 [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: A sequential extraction procedure is developed for the separation of trace levels of hexachloroplatinate, cisplatin and carboplatin from soil, which are then, pre-concentrated using a vesicular coacervative cloud point extraction method prior to their determination as platinum by continuum source ETAAS. Sequential extraction of carboplatin, cisplatin and hexachloroplatinate from a specific red soil is achieved by using the 20% HCl, aqua regia at room temperature and by combination of aqua regia and HF with microwave digestion, respectively. The pre-concentration of these species from the extracted solutions is based on the formation of extractable hydrophobic complexes of PtCl6(2-) anionic species with free cationic head groups solubilizing sites of the Triton X-114 co-surfactant stabilized TOMAC (tri-octyl methyl ammonium chloride) vesicles through electrostatic attraction. This process separates the platinum from bulk aqueous solution into a small vesicular rich phase. The parameters affecting the extraction procedures are optimized. Under the optimized conditions, the achieved pre-concentration factor is 20 and detection limit is 0.5ngg(-1) for soil and 0.02ngmL(-1) for water samples. The spiked recoveries of hexachloroplatinate, cisplatin and carboplatin in water and soil extracts in the vesicular coacervative extraction are in the range of 96-102% at 0.5-1ngmL(-1) with relative standard deviation of 1-3%. The accuracy of the method for platinum determination is evaluated by analyzing CCRMP PTC-1a copper-nickel sulfide concentrate and BCR 723 road dust certified reference materials and the obtained results agreed with the certified values with 95% confidence level of student t-test. The results were also compared to mixed-micelle (MM)-CPE method reported in the literature [22]. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1311 [Js] Journal subset: IM [St] Status: In-Data-Review

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[PMID]: 24161561 [Au] Autor: Challier E; Lisa MN; Nerli BB; Calcaterra NB; Armas P [Ad] Address: Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, CCT-Rosario, Ocampo y Esmeralda, S2000FHQ Rosario, Argentina. [Ti] Title: Novel high-performance purification protocol of recombinant CNBP suitable for biochemical and biophysical characterization. [So] Source: Protein Expr Purif;93:23-31, 2014 Jan. [Is] ISSN: 1096-0279 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Cellular nucleic acid binding protein (CNBP) is a highly conserved multi-zinc knuckle protein that enhances c-MYC expression, is related to certain human muscular diseases and is required for proper rostral head development. CNBP binds to single-stranded DNA (ssDNA) and RNA and acts as nucleic acid chaperone. Despite the advances made concerning CNBP biological roles, a full knowledge about the structure-function relationship has not yet been achieved, likely due to difficulty in obtaining pure and tag-free CNBP. Here, we report a fast, simple, reproducible, and high-performance expression and purification protocol that provides recombinant tag-free CNBP from Escherichia coli cultures. We determined that tag-free CNBP binds its molecular targets with higher affinity than tagged-CNBP. Furthermore, fluorescence spectroscopy revealed the presence of a unique and conserved tryptophan, which is exposed to the solvent and involved, directly or indirectly, in nucleic acid binding. Size-exclusion HPLC revealed that CNBP forms homodimers independently of nucleic acid binding and coexist with monomers as non-interconvertible forms or in slow equilibrium. Circular dichroism spectroscopy showed that CNBP has a secondary structure dominated by random-coil and ß-sheet coincident with the sequence-predicted repetitive zinc knuckles motifs, which folding is required for CNBP structural stability and biochemical activity. CNBP structural stability increased in the presence of single-stranded nucleic acid targets similar to other unstructured nucleic acid chaperones. Altogether, data suggest that CNBP is a flexible protein with interspersed structured zinc knuckles, and acquires a more rigid structure upon nucleic acid binding. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1311 [St] Status: In-Data-Review

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[PMID]: 24043224 [Au] Autor: Lizhang J; Taylor SD; Jin Z; Fisher J; Williams S [Ad] Address: Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK. [Ti] Title: Effect of clearance on cartilage tribology in hip hemi-arthroplasty. [So] Source: Proc Inst Mech Eng H;227(12):1284-91, 2013 Dec. [Is] ISSN: 2041-3033 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Hemi-arthroplasty of the hip (an artificial femoral head articulating against the natural acetabulum) is used to treat fractured necks of femur; however, there is evidence that articulation causes erosion of the cartilage, resulting in pain for the patient. Parameters that may influence this cartilage erosion include head material and roughness, clearance between the head and acetabulum and activity levels of the patient. This study has assessed the effect of clearance of hemi-arthroplasty articulations on the contact stress, friction and cartilage deformation in an in vitro tribological simulation of the hemi-arthroplasty joint that applied dynamic loads and motion. It has been demonstrated that peak contact stress increased from 5.6 to 10.6 MPa as radial clearance increased from small (<0.6 mm) to extra-large (>1.8 mm). In all samples, friction factor increased with time and was significantly less with extra-large clearances compared to small (<0.6 mm), medium (0.6-1.2 mm) and large (1.2-1.8 mm) clearances. The cartilage deformation observed was significantly greater in acetabulum samples paired to give small or extra-large clearances compared to those with medium or large clearances. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1311 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1177/0954411913502156

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[PMID]: 24275821 [Au] Autor: Horváth I; Vigh L; Farkas T; Horváth LI; Dudits D [Ad] Address: Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, P.O. Box 521, H-6701, Szeged, Hungary. [Ti] Title: Effect of choline chloride on fatty acid chain ordering in membranes of wheat (Triticum aestvium L. cv. Miranovskaja 808). [So] Source: Planta;153(5):476-80, 1981 Dec. [Is] ISSN: 0032-0935 [Cp] Country of publication: Germany [La] Language: eng [Ab] Abstract: A winter variety (Miranovskaja 808) of wheat (Triticum aestivum L.) was grown in water cultures containing 0, 5, 15, 30, and 60 mM choline chloride. There was an increase in the phosphatidylcholine level at the expense of phosphatidic acid, parallel with an increasing choline concentration in the cultivating medium. While the ratio of free sterols to phospholipids remained essentially constant in the seedlings, there was an increase in the ratio of saturated-to-unsaturated fatty acids of the phospholipid fraction. Probing the protoplasts obtained from the leaves of the seedlings, with spin labeled 5-doxyl- and 16-doxyl stearic acids, indicated a progressive rigidifying of the hydrophobic core of the plasmalemma. It is suggested that this is a manifestation of compensatory mechanisms by which plants attempt to maintain unchanged average membrane fluidity across their membranes in response to the fluidizing effect of choline head groups. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1311 [St] Status: In-Data-Review [do] DOI: 10.1007/BF00394990

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[PMID]: 24277336 [Au] Autor: Römer KG; Freundt KJ; Alanis OT; de Torres GG [Ad] Address: Institute of Pharmacology and Toxicology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Maybachstr. 14-16, D-6800, Mannheim. [Ti] Title: Delayed ethanol elimination in rats after application of cefamandole or cefoperazone. [So] Source: Pharm Res;1(5):234-5, 1984 Sep. [Is] ISSN: 0724-8741 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Adult female Sprague-Dawley rats received ethanol (2 g/kg b.w., i.p.) 18 hours after pretreatment with the betalactam-antibiotics cefamandole (CMD) or cefoperazone (CPZ) (1 mmol/kg b.w. each, i.p.). The blood ethanol concentrations, determined repeatedly within 4 hours by head space GC, were increasingly elevated after CMD or CPZ up to twice the respective control values. The possible clinical and forensic significance of these findings for the therapeutic use of CMD or CPZ is pointed out. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1311 [St] Status: In-Data-Review [do] DOI: 10.1023/A:1016381532166

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[PMID]: 24278018 [Au] Autor: Liu Q; Stone JA; Bradel-Tretheway B; Dabundo J; Benavides Montano JA; Santos-Montanez J; Biering SB; Nicola AV; Iorio RM; Lu X; Aguilar HC [Ad] Address: Paul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, United States of America. [Ti] Title: Unraveling a three-step spatiotemporal mechanism of triggering of receptor-induced nipah virus fusion and cell entry. [So] Source: PLoS Pathog;9(11):e1003770, 2013 Nov. [Is] ISSN: 1553-7374 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Membrane fusion is essential for entry of the biomedically-important paramyxoviruses into their host cells (viral-cell fusion), and for syncytia formation (cell-cell fusion), often induced by paramyxoviral infections [e.g. those of the deadly Nipah virus (NiV)]. For most paramyxoviruses, membrane fusion requires two viral glycoproteins. Upon receptor binding, the attachment glycoprotein (HN/H/G) triggers the fusion glycoprotein (F) to undergo conformational changes that merge viral and/or cell membranes. However, a significant knowledge gap remains on how HN/H/G couples cell receptor binding to F-triggering. Via interdisciplinary approaches we report the first comprehensive mechanism of NiV membrane fusion triggering, involving three spatiotemporally sequential cell receptor-induced conformational steps in NiV-G: two in the head and one in the stalk. Interestingly, a headless NiV-G mutant was able to trigger NiV-F, and the two head conformational steps were required for the exposure of the stalk domain. Moreover, the headless NiV-G prematurely triggered NiV-F on virions, indicating that the NiV-G head prevents premature triggering of NiV-F on virions by concealing a F-triggering stalk domain until the correct time and place: receptor-binding. Based on these and recent paramyxovirus findings, we present a comprehensive and fundamentally conserved mechanistic model of paramyxovirus membrane fusion triggering and cell entry. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1311 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1371/journal.ppat.1003770

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[PMID]: 24278382 [Au] Autor: Acosta-Cabronero J; Williams GB; Cardenas-Blanco A; Arnold RJ; Lupson V; Nestor PJ [Ad] Address: German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany ; Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom. [Ti] Title: In Vivo Quantitative Susceptibility Mapping (QSM) in Alzheimer's Disease. [So] Source: PLoS One;8(11):e81093, 2013. [Is] ISSN: 1932-6203 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: BACKGROUND: This study explores the magnetostatic properties of the Alzheimer's disease brain using a recently proposed, magnetic resonance imaging, postprocessed contrast mechanism. Quantitative susceptibility mapping (QSM) has the potential to monitor in vivo iron levels by reconstructing magnetic susceptibility sources from field perturbations. However, with phase data acquired at a single head orientation, the technique relies on several theoretical approximations and requires fast-evolving regularisation strategies. METHODS: In this context, the present study describes a complete methodological framework for magnetic susceptibility measurements with a review of its theoretical foundations. FINDINGS AND SIGNIFICANCE: The regional and whole-brain cross-sectional comparisons between Alzheimer's disease subjects and matched controls indicate that there may be significant magnetic susceptibility differences for deep brain nuclei - particularly the putamen - as well as for posterior grey and white matter regions. The methodology and findings described suggest that the QSM method is ready for larger-scale clinical studies. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1311 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1371/journal.pone.0081093

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[PMID]: 24278325 [Au] Autor: Urashima M; Hama T; Suda T; Suzuki Y; Ikegami M; Sakanashi C; Akutsu T; Amagaya S; Horiuchi K; Imai Y; Mezawa H; Noya M; Nakashima A; Mafune A; Kato T; Kojima H [Ad] Address: Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. [Ti] Title: Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. [So] Source: PLoS One;8(11):e80828, 2013. [Is] ISSN: 1932-6203 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: BACKGROUND: Tobacco and alcohol consumption are risk factors for head and neck squamous cell carcinoma (HNSCC). Recently, whole-exome sequencing clarified that smoking increased TP53 and other mutations in HNSCC; however, the effects of alcohol consumption on these genetic alterations remain unknown. We explored the association between alcohol consumption and somatic copy-number alterations (SCNAs) across the whole genome in human papillomavirus (HPV)-negative HNSCCs, and compared with the effects of smoking on genetic alterations. METHODS: SCNA and TP53 mutations in tumor samples were examined by high-resolution comparative genomic hybridization microarray 180K and by direct sequencing, respectively, and statistically analyzed for associations with alcohol consumption and smoking during the 20 years preceding diagnosis of HNSCC. Probes with a corrected p-value (=q-value) less than 0.05 and fold change greater than 1.2 or less than -1.2 were considered statistically significant. RESULTS: A total of 248 patients with HNSCC were enrolled. In the HPV-negative patients (n=221), heavy alcohol consumption was significantly associated with SCNAs of oncogenes/oncosuppressors that were previously reported to occur frequently in HNSCCs: CDKN2A (q=0.005), FHIT (q=0.005), 11q13 region including CCND1, FADD and CTTN (q=0.005), ERBB2 (HER2) (q=0.009), 3q25-qter including CCNL1, TP63, DCUN1D1 and PIK3CA (q=0.014), and CSMD1 (q=0.019). But, TP53 mutations were not affected. In contrast, smoking was associated with increased risk of TP53 mutations, but did not induce any significant SCNAs of oncogenes/oncosuppressors. CONCLUSION: These results suggest that both alcohol consumption and smoking had distinct effects on genetic alterations in HNSCCs. Heavy alcohol consumption may trigger previously known and unknown SCNAs, but may not induce TP53 mutation. In contrast, smoking may induce TP53 mutation, but may not trigger any SCNAs. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1311 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1371/journal.pone.0080828

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