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[PMID]: 24440650
[Au] Autor:Homolka P; Leithner R; Billinger J; Gruber M
[Ad] Address:Zentrum für Medizinische Physik und Biomedizinische Technik, Medizinische Universität Wien, Währinger Gürtel 18-20, A-1090 Wien, Österreich. Electronic address: peter.homolka@meduniwien.ac.at....
[Ti] Title:Ergebnisse der Österreichischen CT-Dosisstudie 2010: Effektive Dosen der häufigsten CT-Untersuchungen und Unterschiede zwischen Anwendern. [Results of the Austrian CT dose study 2010: Typical effective doses of the most frequent CT examinations].
[So] Source:Z Med Phys;24(3):224-30, 2014 Sep.
[Is] ISSN:1876-4436
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:PURPOSE: To determine typical doses from common CT examinations of standard sized adult patients and their variability between CT operators for common CT indications. MATERIALS AND METHODS: In a nationwide Austrian CT dose survey doses from approx. 10,000 common CT examinations of adults during 2009 and 2010 were collected and "typical" radiation doses to the "average patient", which turned out to have 75.6kg body mass, calculated. Conversion coefficients from DLP to effective dose were determined and effective doses calculated according to ICRP 103. Variations of typically applied doses to the "average patient" were expressed as ratios between 90(th) and 10(th) percentile (inter-percentile width, IPW90/10), 1(st) and 3(rd) quartile (IPW75/25), and Maximum/Minimum. RESULTS: Median effective doses to the average patients for standard head and neck scans were 1.8 mSv (cervical spine), 1.9 mSv (brain: trauma/bleeding, stroke) to 2.2 mSv (brain: masses) with typical variation between facilities of a factor 2.5 (IPW90/10) and 1.7 (IPW75/25). In the thorax region doses were 6.4 to 6.8 mSv (pulmonary embolism, pneumonia and inflammation, oncologic scans), the variation between facilities was by a factor of 2.1 (IPW90/10) and 1.5 (IPW75/25), respectively. In the abdominal region median effective doses from 6.5 mSv (kidney stone search) to 22 mSv (liver lesions) were found (acute abdomen, staging/metastases, lumbar spine: 9-12 mSv; oncologic abdomen plus chest 16 mSv; renal tumor 20 mSv). Variation factors between facilities were on average for abdominal scans 2.7 (IPW90/10) and 1.8 (IPW75/25). CONCLUSION: Variations between CT operators are generally moderate for most operators, but in some indications the ratio between the minimum and the maximum of average dose to the typical standard patients exceeds a factor of 4 or even 5. Therefore, comparing average doses to Diagnostic Reference Levels (DRLs) and optimizing protocols need to be encouraged.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 332082 MEDLINE  
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[PMID]: 25002536
[Au] Autor:Zilio N; Codlin S; Vashisht AA; Bitton DA; Head SR; Wohlschlegel JA; Bähler J; Boddy MN
[Ad] Address:Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA....
[Ti] Title:A novel histone deacetylase complex in the control of transcription and genome stability.
[So] Source:Mol Cell Biol;34(18):3500-14, 2014 Sep 15.
[Is] ISSN:1098-5549
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The acetylation state of histones, controlled by histone acetyltransferases (HATs) and deacetylases (HDACs), profoundly affects DNA transcription and repair by modulating chromatin accessibility to the cellular machinery. The Schizosaccharomyces pombe HDAC Clr6 (human HDAC1) binds to different sets of proteins that define functionally distinct complexes: I, I', and II. Here, we determine the composition, architecture, and functions of a new Clr6 HDAC complex, I'', delineated by the novel proteins Nts1, Mug165, and Png3. Deletion of nts1 causes increased sensitivity to genotoxins and deregulated expression of Tf2 elements, long noncoding RNA, and subtelomeric and stress-related genes. Similar, but more pervasive, phenotypes are observed upon Clr6 inactivation, supporting the designation of complex I'' as a mediator of a key subset of Clr6 functions. We also reveal that with the exception of Tf2 elements, the genome-wide loading sites and loci regulated by Clr6 I″ do not correlate. Instead, Nts1 loads at genes that are expressed in midmeiosis, following oxidative stress, or are periodically expressed. Collective data suggest that Clr6 I'' has (i) indirect effects on gene expression, conceivably by mediating higher-order chromatin organization of subtelomeres and Tf2 elements, and (ii) direct effects on the transcription of specific genes in response to certain cellular or environmental stimuli.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1128/MCB.00519-14

  3 / 332082 MEDLINE  
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[PMID]: 24640955
[Au] Autor:Arien-Zakay H; Gincberg G; Nagler A; Cohen G; Liraz-Zaltsman S; Trembovler V; Alexandrovich AG; Matok I; Galski H; Elchalal U; Lelkes PI; Lazarovici P; Shohami E
[Ad] Address:1 School of Pharmacy Institute for Drug Research, The Hebrew University of Jerusalem , Jerusalem, Israel .
[Ti] Title:Neurotherapeutic Effect of Cord Blood Derived CD45(+) Hematopoietic Cells in Mice after Traumatic Brain Injury.
[So] Source:J Neurotrauma;31(16):1405-16, 2014 Aug 15.
[Is] ISSN:1557-9042
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Abstract Treatment of traumatic brain injury (TBI) is still an unmet need. Cell therapy by human umbilical cord blood (HUCB) has shown promising results in animal models of TBI and is under evaluation in clinical trials. HUCB contains different cell populations but to date, only mesenchymal stem cells have been evaluated for therapy of TBI. Here we present the neurotherapeutic effect, as evaluated by neurological score, using a single dose of HUCB-derived mononuclear cells (MNCs) upon intravenous (IV) administration one day post-trauma in a mouse model of closed head injury (CHI). Delayed (eight days post-trauma) intracerebroventricular administration of MNCs showed improved neurobehavioral deficits thereby extending the therapeutic window for treating TBI. Further, we demonstrated for the first time that HUCB-derived pan-hematopoietic CD45 positive (CD45(+)) cells, isolated by magnetic sorting and characterized by expression of CD45 and CD11b markers (96-99%), improved the neurobehavioral deficits upon IV administration, which persisted for 35 days. The therapeutic effect was in a direct correlation to a reduction in the lesion volume and decreased by pre-treatment of the cells with anti-human-CD45 antibody. At the site of brain injury, 1.5-2 h after transplantation, HUCB-derived cells were identified by near infrared scanning and immunohistochemistry using anti-human-CD45 and anti-human-nuclei antibodies. Nerve growth factor and vascular endothelial growth factor levels were differentially expressed in both ipsilateral and contralateral brain hemispheres, thirty-five days after CHI, measured by enzyme-linked immunosorbent assay. These findings indicate the neurotherapeutic potential of HUCB-derived CD45(+) cell population in a mouse model of TBI and propose their use in the clinical setting of human TBI.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1089/neu.2013.3270

  4 / 332082 MEDLINE  
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[PMID]: 25080482
[Au] Autor:Zou J; Gorgoglione B; Taylor NG; Summathed T; Lee PT; Panigrahi A; Genet C; Chen YM; Chen TY; Ul Hassan M; Mughal SM; Boudinot P; Secombes CJ
[Ad] Address:Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, United Kingdom; j.j.zou@abdn.ac.uk c.secombes@abdn.ac.uk....
[Ti] Title:Salmonids Have an Extraordinary Complex Type I IFN System: Characterization of the IFN Locus in Rainbow Trout Oncorhynchus mykiss Reveals Two Novel IFN Subgroups.
[So] Source:J Immunol;193(5):2273-86, 2014 Sep 1.
[Is] ISSN:1550-6606
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Fish type I IFNs are classified into two groups with two (group I) or four (group II) cysteines in the mature peptide and can be further divided into four subgroups, termed IFN-a, -b, -c, and -d. Salmonids possess all four subgroups, whereas other teleost species have one or more but not all groups. In this study, we have discovered two further subgroups (IFN-e and -f) in rainbow trout Oncorhynchus mykiss and analyzed the expression of all six subgroups in rainbow trout and brown trout Salmo trutta. In rainbow trout RTG-2 and RTS-11 cells, polyinosinic-polycytidylic acid stimulation resulted in early activation of IFN-d, whereas the IFN-e subgroup containing the highest number of members showed weak induction. In contrast with the cell lines, remarkable induction of IFN-a, -b, and -c was detected in primary head kidney leukocytes after polyinosinic-polycytidylic acid treatment, whereas a moderate increase of IFNs was observed after stimulation with resiquimod. Infection of brown trout with hemorrhagic septicemia virus resulted in early induction of IFN-d, -e, and -f and a marked increase of IFN-b and IFN-c expression in kidney and spleen. IFN transcripts were found to be strongly correlated with the viral burden and with marker genes of the IFN antiviral cascade. The results demonstrate that the IFN system of salmonids is far more complex than previously realized, and in-depth research is required to fully understand its regulation and function.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.4049/jimmunol.1301796

  5 / 332082 MEDLINE  
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[PMID]: 24925733
[Au] Autor:Kaffenberger BH; Mathis J; Zirwas MJ
[Ad] Address:Division of Dermatology, Ohio State University College of Medicine, Columbus, Ohio; Ohio State University College of Medicine, Columbus, Ohio.
[Ti] Title:A retrospective descriptive study of oral azole antifungal agents in patients with patch test-negative head and neck predominant atopic dermatitis.
[So] Source:J Am Acad Dermatol;71(3):480-3, 2014 Sep.
[Is] ISSN:1097-6787
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Head and neck dermatitis is a subtype of atopic dermatitis driven by Malassezia yeast. OBJECTIVE: We sought to evaluate the response of these patients to systemic azole antifungals. METHODS: We queried the electronic medical records from our institution for patients that were referred for allergy patch testing, were ultimately given the diagnosis of head and neck dermatitis, and were treated with oral azole antifungals over a 2-year period. RESULTS: Twenty-four patients met inclusion criteria and were analyzed. Most patients noted their characteristic flare beginning during their teenage, young adult, or adult years. All were noted to have some involvement of the head and neck, and 17 responded to treatment. The mean time taking an azole antifungal medication was 8 months, with a mean overall follow-up of 10 months. LIMITATIONS: This was a retrospective descriptive study, from a single institution, of a limited number of patients, and did not use a validated scoring system. CONCLUSION: Itraconazole and other azole antifungals were an effective treatment for more than two-thirds of adult patients with head and neck predominant atopic dermatitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 332082 MEDLINE  
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[PMID]: 25014065
[Au] Autor:Yang S; Stepien D; Hanseman D; Robinson B; Goodman MD; Pritts TA; Caldwell CC; Remick DG; Lentsch AB
[Ad] Address:1Institute for Military Medicine, Division of Trauma and Critical Care, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH. 2Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA.
[Ti] Title:Substance p mediates reduced pneumonia rates after traumatic brain injury.
[So] Source:Crit Care Med;42(9):2092-100, 2014 Sep.
[Is] ISSN:1530-0293
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Traumatic brain injury results in significant morbidity and mortality and is associated with infectious complications, particularly pneumonia. However, whether traumatic brain injury directly impacts the host response to pneumonia is unknown. The objective of this study was to determine the nature of the relationship between traumatic brain injury and the prevalence of pneumonia in trauma patients and investigate the mechanism of this relationship using a murine model of traumatic brain injury with pneumonia. DESIGN: Data from the National Trauma Data Bank and a murine model of traumatic brain injury with postinjury pneumonia. SETTING: Academic medical centers in Cincinnati, OH, and Boston, MA. PATIENTS/SUBJECTS: Trauma patients in the National Trauma Data Bank with a hospital length of stay greater than 2 days, age of at least 18 years at admission, and a blunt mechanism of injury. Subjects were female ICR mice 8-10 weeks old. INTERVENTIONS: Administration of a substance P receptor antagonist in mice. MEASUREMENTS AND MAIN RESULTS: Pneumonia rates were measured in trauma patients before and after risk adjustment using propensity scoring. In addition, survival and pulmonary inflammation were measured in mice undergoing traumatic brain injury with or without pneumonia. After risk adjustment, we found that traumatic brain injury patients had significantly lower rates of pneumonia compared to blunt trauma patients without traumatic brain injury. A murine model of traumatic brain injury reproduced these clinical findings with mice subjected to traumatic brain injury demonstrating increased bacterial clearance and survival after induction of pneumonia. To determine the mechanisms responsible for this improvement, the substance P receptor was blocked in mice after traumatic brain injury. This treatment abrogated the traumatic brain injury-associated increases in bacterial clearance and survival. CONCLUSIONS: The data demonstrate that patients with traumatic brain injury have lower rates of pneumonia compared to non-head-injured trauma patients and suggest that the mechanism of this effect occurs through traumatic brain injury-induced release of substance P, which improves innate immunity to decrease pneumonia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1097/CCM.0000000000000486

  7 / 332082 MEDLINE  
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[PMID]: 25109877
[Au] Autor:Hoadley KA; Yau C; Wolf DM; Cherniack AD; Tamborero D; Ng S; Leiserson MD; Niu B; McLellan MD; Uzunangelov V; Zhang J; Kandoth C; Akbani R; Shen H; Omberg L; Chu A; Margolin AA; Van't Veer LJ; Lopez-Bigas N; Laird PW; Raphael BJ; Ding L; Robertson AG; Byers LA; Mills GB; Weinstein JN; Van Waes C; Chen Z; Collisson EA; Benz CC; Perou CM; Stuart JM; Cancer Genome Atlas Research Network
[Ad] Address:Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA....
[Ti] Title:Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin.
[So] Source:Cell;158(4):929-44, 2014 Aug 14.
[Is] ISSN:1097-4172
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 332082 MEDLINE  
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[PMID]: 25003324
[Au] Autor:Shapiro AB; Gu RF; Gao N
[Ad] Address:Biology Department, Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, United States. Electronic address: adam.shapiro@astrazeneca.com.
[Ti] Title:Dimerization of isolated Pseudomonas aeruginosa lipopolysaccharide transporter component LptA.
[So] Source:Biochem Biophys Res Commun;450(4):1327-32, 2014 Aug 8.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:LptA is a soluble periplasmic component of the lipopolysaccharide (LPS) transport system of Gram-negative bacteria that transports newly synthesized LPS from the inner membrane to the outer leaflet of the outer membrane. LptA links the inner membrane components (LptBFGC) to the outer membrane components (LptDE), but it is uncertain whether LptA is a freely moving LPS shuttle or part of a stable trans-periplasm structure. Escherichiacoli LptA forms highly polymerized head-to-tail oligomers in solution, but dimers in vivo. We studied the oligomerization of purified Pseudomonasaeruginosa LptA. Size-exclusion chromatography showed that P. aeruginosa LptA, unlike E. coli LptA, is a dimer over a wide range of concentrations. Chemical crosslinking with bis(sulfosuccinimidyl) suberate confirmed that dimers were the predominant species even at sub-micromolar LptA concentrations, which was unaffected by LPS binding. Mass spectrometry of crosslinked dimers showed that crosslinks occurred between the N-terminal α-amino group and either Lys-172 or Lys-173 near the C-terminus. These results support a hypothetical structure for the dimer of isolated P. aeruginosa LptA in which the N-terminus of one monomer is in close proximity to the C-terminus of the other, and the same surface of each monomer forms the interface between them, preventing further oligomerization.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 332082 MEDLINE  
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[PMID]: 24524863
[Au] Autor:Karamanos E; Teixeira PG; Sivrikoz E; Varga S; Chouliaras K; Okoye O; Hammer P
[Ad] Address:Division of Acute Care Surgery (Trauma, Emergency Surgery, and Surgical Critical Care), University of Southern California-Keck School of Medicine, Los Angeles County General Hospital (LAC + USC), 2051 Marengo Street, C5L100, Los Angeles, CA 90033-4525, USA. Electronic address: ef.karamanos@gmail.com...
[Ti] Title:Intracranial pressure versus cerebral perfusion pressure as a marker of outcomes in severe head injury: a prospective evaluation.
[So] Source:Am J Surg;208(3):363-71, 2014 Sep.
[Is] ISSN:1879-1883
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Intracranial pressure (ICP) monitoring is a standard of care in severe traumatic brain injury when clinical features are unreliable. It remains unclear, however, whether elevated ICP or decreased cerebral perfusion pressure (CPP) predicts outcome. METHODS: This is a prospective observational study of patients sustaining severe blunt head injury, admitted to the surgical intensive care unit at the Los Angeles County and University of Southern California Medical Center between January 2010 and December 2011. The study population was stratified according to the findings of ICP and CPP. Primary outcomes were overall in-hospital mortality and mortality because of cerebral herniation. Secondary outcomes were development of complications during the hospitalization. RESULTS: A total of 216 patients met Brain Trauma Foundation guidelines for ICP monitoring. Of those, 46.8% (n = 101) were subjected to the intervention. Sustained elevated ICP significantly increased all in-hospital mortality (adjusted odds ratio [95% confidence interval]: 3.15 [1.11, 8.91], P = .031) and death because of cerebral herniation (adjusted odds ratio [95% confidence interval]: 9.25 [1.19, 10.48], P = .035). Decreased CPP had no impact on mortality. CONCLUSIONS: A single episode of sustained increased ICP is an accurate predictor of poor outcomes. Decreased CPP did not affect survival.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  10 / 332082 MEDLINE  
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[PMID]: 25084321
[Au] Autor:He M; Li WC; Sun DM; Ma KJ; Zhao ZQ; Li BX; Li L
[Ad] Address:From the *Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University; †Shanghai Key Laboratory of Crime Scene Evidence, Institute of Forensic Science, Shanghai Public Security Bureau; ‡Institute of Criminal Science, Pudong Branch of Shanghai Public Security Bureau; §Forensic Science Center, East China University of Political Science and Law, Shanghai, People's Republic of China; and ∥Division of Forensic Pathology, University of Maryland School of Medicine, Baltimore, MD.
[Ti] Title:Epitome of China's Unnatural Deaths: A Historically Retrospective Study of Forensic Autopsy Cases in Shanghai Public Security Bureau From 1990 to 1999.
[So] Source:Am J Forensic Med Pathol;35(3):218-21, 2014 Sep.
[Is] ISSN:1533-404X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The unnatural death investigation in China seems vague to the world. Shanghai is one of the largest city located in Yangtze River Delta in the East China. This study is committed to lift the veil of unnatural death investigation and describe the epitome of China's unnatural deaths. Based on the 7302 forensic report archives from 1990 to 1999 in Shanghai Public Security Bureau, statistics were carried out in 5 areas according to the manner of death. In 3502 accidental deaths, there was a rapid increase during the 1990s, and 71.6% were involved in traffic accidents whose major cause of death was head and neck injuries. The first 3 causes of death in nontraffic accidents (994) were head and neck injuries (42.8%), poisoning (11.8%), and drowning (9.0%). In 2456 homicides, sharp force injury (36.7%), blunt force injury (35.8%), and manual strangulation (12.9%) were the first 3 causes of death. In 563 suicides, drug/chemical intoxication (40.1%), hanging (23.4%), and injuries because of fall from height (11.4%) were the 3 leading causes of death, especially pesticides ingestion. The causes of natural deaths were diseases mainly in circulatory system (23.1%), central nervous system (12.8%), and respiratory system (6.4%). However, the cause of death remained undetermined in 500 victims. Childhood fatalities were different. The victims of accidents and homicides were nearly equal, and the main cause of homicide was manual strangulation. Besides, 1997 was the landmark year when drug abuse began to emerge in Shanghai.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/PAF.0000000000000115


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