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[PMID]: 24590649 [Au] Autor: Bonomi M; Abbott RW; Patsias A; Misiukiewicz K; Demicco EG; Zhang D; Kaufman A; Genden EM; Posner M [Ad] Address: Mount Sinai Hospital, New York, NY marcelo.bonomi@mssm.edu.... [Ti] Title: Role of Human Papillomavirus and p16 Staining in a Patient With Head and Neck Cancer Presenting With a Synchronous Lung Nodule: A Case Report and Review of the Literature. [So] Source: J Clin Oncol;33(3):e13-5, 2015 Jan 20. [Is] ISSN: 1527-7755 [Cp] Country of publication: United States [La] Language: eng [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1501 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1200/JCO.2013.50.0231

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[PMID]: 25275869 [Au] Autor: Li C; Layman AJ; Geary R; Anson E; Carey JP; Ferrucci L; Agrawal Y [Ad] Address: *Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.; †Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.; ‡Department of Kinesiology, University of Maryland, College Park, Maryland, U.S.A.; and §Longitudinal Studies Section, National Institute on Aging, Baltimore, Maryland, U.S.A. [Ti] Title: Epidemiology of vestibulo-ocular reflex function: data from the Baltimore longitudinal study of aging. [So] Source: Otol Neurotol;36(2):267-72, 2015 Feb. [Is] ISSN: 1537-4505 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: OBJECTIVE: To determine age-related changes in vestibulo-ocular reflex (VOR) function in community-dwelling adults, and evaluate these for associations with demographic characteristics and cardiovascular risk factors. STUDY DESIGN: Cross-sectional analysis within the Baltimore Longitudinal Study of Aging (BLSA), a longitudinal prospective cohort study. SETTING: Vestibular testing laboratory within an acute care teaching hospital. PATIENTS: Community-dwelling adults enrolled in the BLSA. INTERVENTION(S): Horizontal VOR gain measurement using video head-impulse testing and visual acuity testing. MAIN OUTCOME MEASURE(S): VOR gain was calculated as the ratio of eye velocity to head velocity. Demographic and cardiovascular risk factor data were collected through study questionnaires. RESULTS: One hundred nine subjects were analyzed with mean age (SD) 69.9 years (14.2), with a range from 26 to 92 years. VOR gain remained stable from age 26 to 79 after which it significantly declined at a rate of 0.012/year (p = 0.033) in adjusted analyses. Individuals aged 80 years or older had a nearly 8-fold increased odds of VOR gain less than 0.80 relative to those aged less than 80 years in multivariate models (prevalence of 13.2% vs. 2.8%; OR 7.79, 95% CI: 1.04-58.38). Otherwise, VOR gain did not differ significantly across demographic or cardiovascular risk groups. CONCLUSION: We report age-related decline in VOR function in individuals aged 80 years and older. Further analyses are in progress to establish the significance of these VOR abnormalities to functional and mobility outcomes in older individuals. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1501 [Cu] Class update date: 150117 [Lr] Last revision date: 150117 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1097/MAO.0000000000000610

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[PMID]: 25589858 [Au] Autor: Turan D; Dogan E; Kaya C; Kanyilmaz M [Ad] Address: Recep Tayyip Erdogan University, Faculty of Fisheries and Aquatic Sciences, 53100 Rize, Turkey.... [Ti] Title: Salmokottelati, a new species of trout from Alakir Stream, draining to the Mediterranean in southern Anatolia, Turkey (Teleostei, Salmonidae). [So] Source: Zookeys;(462):135-51, 2014. [Is] ISSN: 1313-2989 [Cp] Country of publication: Bulgaria [La] Language: eng [Ab] Abstract: Salmokottelati sp. n., is described from Alakir Stream (Mediterranean basin) in Turkey. It is distinguished from other Anatolian Salmo species by a combination of the following characters (none unique to the species): general body colour greenish to silvery in life; 7-9 parr marks along lateral line; four dark bands on flank absent in both sexes; black ocellated spots few, present only on upper part of flank in individuals smaller than 160 mm SL but in larger both males and females black spots numerous and located on back and middle and upper part of flank; red spots few to numerous, scattered on median, and half of lower and upper part of flank; head long (length 29-33% SL in males, 26-32 in females); mouth large (length of mouth gape 13-19% SL in males, 12-15 in females); maxilla long (length 10-13% SL in males, 8-12 in females); 105-113 lateral line scales; 24-29 scale rows between lateral line and dorsal-fin origin, 17-19 scale rows between lateral line and anal-fin origin; 13-15 scales between lateral line and adipose-fin insertion. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1501 [Cu] Class update date: 150117 [Lr] Last revision date: 150117 [Da] Date of entry for processing: 150115 [St] Status: PubMed-not-MEDLINE [do] DOI: 10.3897/zookeys.462.8177

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[PMID]: 25589900 [Au] Autor: Liu HT; Liang CC; Rau CS; Hsu SY; Hsieh CH [Ad] Address: Department of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 123, Ta-Pei Road, Niao-Song District, Kaohsiung City, 833 Taiwan.... [Ti] Title: Alcohol-related hospitalizations of adult motorcycle riders. [So] Source: World J Emerg Surg;10(1):2, 2015. [Is] ISSN: 1749-7922 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: OBJECTIVE: To provide an overview of the demographic characteristics of adult motorcycle riders with alcohol-related hospitalizations. METHODS: Data obtained from the Trauma Registry System were retrospectively reviewed for trauma admissions at a level I trauma center between January 1, 2009 and December 31, 2013. Out of 16,548 registered patients, detailed information was retrieved regarding 1,430 (8.64%) adult motorcycle riders who underwent a blood alcohol concentration (BAC) test. A BAC level of 50 mg/dL was defined as the cut-off value for alcohol intoxication. RESULTS: In this study, alcohol consumption was more frequently noted among male motorcycle riders, those aged 30-49 years, those who had arrived at the hospital in the evening or during the night, and those who did not wear a helmet. Alcohol consumption was associated with a lower percentage of sustained severe injury (injury severity score ≥25) and lower frequencies of specific body injuries, including cerebral contusion (0.6; 95% confidence interval [CI] = 0.42-0.80), lung contusion (0.5; 95% CI = 0.24-0.90), lumbar vertebral fracture (0.1; 95% CI = 0.01-0.80), humeral fracture (0.5; 95% CI = 0.27-0.90), and radial fracture (0.6; 95% CI = 0.40-0.89). In addition, alcohol-intoxicated motorcycle riders who wore helmets had significantly lower frequencies of cranial fracture (0.4; 95% CI = 0.29-0.67), epidural hematoma (0.5; 95% CI = 0.29-0.79), subdural hematoma (0.4; 95% CI = 0.28-0.64), subarachnoid hemorrhage (0.5; 95% CI = 0.32-0.72), and cerebral contusion (0.4; 95% CI = 0.25-0.78). CONCLUSIONS: Motorcycle riders who consumed alcohol presented different characteristics and bodily injury patterns relative to sober patients, suggesting the importance of helmet use to decrease head injuries in alcohol-intoxicated riders. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1501 [Cu] Class update date: 150117 [Lr] Last revision date: 150117 [Da] Date of entry for processing: 150115 [St] Status: PubMed-not-MEDLINE [do] DOI: 10.1186/1749-7922-10-2

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[PMID]: 25376609 [Au] Autor: DeCastro AJ; Cherukuri P; Balboni A; DiRenzo J [Ad] Address: Department of Pharmacology and Toxicology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Program in Experimental and Molecular Medicine, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.... [Ti] Title: ΔNP63α Transcriptionally Activates Chemokine Receptor 4 (CXCR4) Expression to Regulate Breast Cancer Stem Cell Activity and Chemotaxis. [So] Source: Mol Cancer Ther;14(1):225-35, 2015 Jan. [Is] ISSN: 1538-8514 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: ΔNP63α, the predominant TP63 isoform expressed in diverse epithelial tissues, including the mammary gland, is required for the preservation of stem cells and has been implicated in tumorigenesis and metastasis. Despite data characterizing ΔNP63α as a master regulator of stem cell activity, identification of the targets underlying these effects is incompletely understood. Recently, ΔNP63α was identified as a key regulator in the promotion of proinflammatory programs in squamous cell carcinoma of the head and neck. Inflammation has been implicated as a potent driver of cancer stem cell phenotypes and metastasis. In this study, we sought to identify novel targets of ΔNP63α that confer cancer stem cell and prometastatic properties. Data presented here identify the gene encoding the chemokine receptor 4 (CXCR4) as a transcriptional target of ΔNP63α. Our data indicate that ΔNP63α enhances CXCR4 expression in breast cancer cells via its binding at two regions within the CXCR4 promoter. The CXCR4 antagonist AMD3100 was used to demonstrate that the pro-stem cell activity of ΔNP63α is mediated through its regulation of CXCR4. Importantly, we show that ΔNP63α promotes the chemotaxis of breast cancer cells towards the CXCR4 ligand SDF1α, a process implicated in the trafficking of breast cancer cells to sites of metastasis. This study highlights CXCR4 as a previously unidentified target of ΔNP63α, which plays a significant role in mediating ΔNP63α-dependent stem cell activity and chemotaxis toward SDF1α. Our findings suggest that ΔNP63α regulation of CXCR4 may have strong implications in the regulation of cancer stem cells and metastasis. Mol Cancer Ther; 14(1); 225-35. ©2014 AACR. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1501 [Cu] Class update date: 150117 [Lr] Last revision date: 150117 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1158/1535-7163.MCT-14-0194

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[PMID]: 25589967 [Au] Autor: Ding N; Lin W; Zhang XL; Ding WX; Gu B; Ni BQ; Zhang W; Zhang SJ; Wang H [Ad] Address: 1 Department of Respiratory Medicine, 2 Department of Geriatric Medicine, 3 Department of Laboratory Medicine, 4 Department of Cardiothoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.... [Ti] Title: Overnight fluid shifts in subjects with and without obstructive sleep apnea. [So] Source: J Thorac Dis;6(12):1736-41, 2014 Dec. [Is] ISSN: 2072-1439 [Cp] Country of publication: China [La] Language: eng [Ab] Abstract: OBJECTIVE: To investigate the characteristics of baseline body fluid content and overnight fluid shifts between non-obstructive sleep apnea (non-OSA) and obstructive sleep apnea (OSA) subjects. METHODS: A case-controlled study was performed between February 2013 and January 2014, with 36 (18 OSA and 18 non-OSA) outpatients enrolled in this study. Polysomnographic parameters and results of body fluid were compared between the two groups. RESULTS: There were no differences in age, weight, and body mass index (BMI) between groups. Compared with the non-OSA group, OSA group had significantly higher neck circumference (NC) and fluid volume shift in the legs. OSA patients had higher left and right leg fluid indices than non-OSA subjects. There were significant correlations between apnoea-hypopnoea index and baseline fluid indices in both legs as well as the reduction in overnight change in both legs fluid volume. The increase in NC was also significantly correlated with the reduction in overnight change in both legs fluid volume, but not with the change in head and neck fluid volume. There were significant correlations between change in NC and increased fluid shifts in head and neck volume. CONCLUSIONS: OSA patients had a higher baseline fluid content in both legs as compared with non-OSA subjects, which may be the basic factor with regards to fluid shifts in OSA patients. The increase in head and neck fluid shift volume did not directly correlate with the severity of OSA. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1501 [Cu] Class update date: 150117 [Lr] Last revision date: 150117 [Da] Date of entry for processing: 150115 [St] Status: PubMed-not-MEDLINE [do] DOI: 10.3978/j.issn.2072-1439.2014.11.19

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[PMID]: 25589890 [Au] Autor: Walter C; Ziebart T; Sagheb K; Rahimi-Nedjat RK; Manz A; Hess G [Ad] Address: 1. Oral and Maxillofacial Surgery - Plastic Surgery of the University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.... [Ti] Title: Malignant Lymphomas in the Head and Neck Region - a Retrospective, Single-Center Study over 41 Years. [So] Source: Int J Med Sci;12(2):141-5, 2015. [Is] ISSN: 1449-1907 [Cp] Country of publication: Australia [La] Language: eng [Ab] Abstract: OBJECTIVES: Non-Hodgkin lymphomas are malignant neoplastic proliferations of the immune system that can manifest as nodal or extranodal lymphomas. The aim of this study was to retrospectively investigate the site of occurrence of lymphomas in the head and neck area and to analyze the typical symptoms of patients who presented at an oral and maxillofacial surgical department. MATERIAL AND METHODS: All patient files from1971 until 2012 from an Oral and Maxillofacial Surgery of a University were analyzed for the diagnosis non-Hodgkin lymphoma. Epidemiologic data and data regarding the localization of the malignant lymphoma were evaluated. RESULTS: 62 patients, 34 women and 28 men with a non-Hodgkin lymphoma in the head and neck area were treated in the 41 years analyzed. In 87% of the cases the lymphoma belonged to B-cell and in 12% to the T-cell lineage. The average age at the time of diagnosis was 67 years for women (n=34) and 56 years for men. With 22 patients each, the non-Hodgkin lymphoma was localized in either the soft tissues or osseous structures. In the remaining 18 cases, multiple structures were affected. In 33 patients no accompanying nodal manifestation was noticed. In 33 cases the lymphoma was located in the oral cavity. The most common symptoms were swelling (97%), pain (40%) and the existence of an ulcer (11%). CONCLUSION: In the present study more than 50% of the lymphomas were located in the oral cavity. Due to the unspecific symptoms, a histopathological verification of the diagnosis is crucial. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1501 [Cu] Class update date: 150117 [Lr] Last revision date: 150117 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.7150/ijms.10483

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[PMID]: 25589802 [Au] Autor: Saleh Farghaly HR; Mohamed Sayed MH [Ad] Address: Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt ; Department of Radiology, Division of Nuclear Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. [Ti] Title: Technetium-99m dimercaptosuccinic acid scan in evaluation of renal cortical scarring: Is it mandatory to do single photon emission computerized tomography? [So] Source: Indian J Nucl Med;30(1):26-30, 2015 Jan-Mar. [Is] ISSN: 0972-3919 [Cp] Country of publication: India [La] Language: eng [Ab] Abstract: OBJECTIVES: Renal cortical scintigraphy with technetium-99m (Tc-99m) dimercaptosuccinic acid (DMSA) is the method of choice to detect acute pyelonephritis and cortical scarring. Different acquisition methods have been used: Planar parallel-hole or pinhole collimation and single photon emission tomography (SPECT). This study compared planar parallel-hole cortical scintigraphy and dual-head SPECT for detection of cortical defects. PATIENTS AND METHODS: We retrospectively reviewed 190 consecutive patients with 380 kidneys and 200 DMSA scans referred to rule out renal cortical scarring. The diagnoses were 52 vesicoureteric reflux, 61 recurrent urinary tract infection, 39 hydronephrosis, 20 renal impairment, and 18 hypertension. All patients were imaged 3 h after injection of Tc-99m DMSA with SPECT and planar imaging (posterior, anterior, left, and right posterior oblique views). For each patient, planar and SPECT images were evaluated at different sittings, in random order. Each kidney was divided into three cortical segments (upper, middle and lower) and was scored as normal or reduced uptake. The linear correlation coefficient for the number of abnormal segments detected between planner and SPECT techniques was calculated. RESULTS: From 200 DMSA scans, 100 scans were positive for scar in SPECT images, from which only 95 scans were positive for scar in planner imaging. Out of the five mismatched scans, three scans were for patients with renal impairment and high background activity and two scans were for very small scars. No significant difference was seen in the average number of abnormal segments detected by planar versus SPECT imaging (P = 0.31). The average correlation coefficient between was high (r = 0.91 - 0.92). CONCLUSIONS: Tc-99m DMSA renal cortical scanning using SPECT offers no statistically significant diagnostic advantage over multiple views planar imaging for detection of cortical defect. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1501 [Cu] Class update date: 150117 [Lr] Last revision date: 150117 [Da] Date of entry for processing: 150115 [St] Status: PubMed-not-MEDLINE [do] DOI: 10.4103/0972-3919.147530

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[PMID]: 25590038 [Au] Autor: Butler IJ; Lankford JE; Hashmi SS; Numan MT [Ad] Address: Division of Child and Adolescent Neurology, Department of Pediatrics, The University of Texas Medical School at Houston Houston, Texas.... [Ti] Title: Biogenic amine metabolism in juvenile neurocardiogenic syncope with dysautonomia. [So] Source: Ann Clin Transl Neurol;1(4):251-7, 2014 Apr. [Is] ISSN: 2328-9503 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: OBJECTIVE: Biogenic amine brain levels and their cerebral metabolism are frequently studied by quantitation of biogenic amine metabolites in cerebrospinal fluid (CSF) compared to age-matched controls. There is a paucity of studies in adolescents and young adults investigating the potential role of disordered cerebral biogenic amine metabolism in young patients who have dysautonomia based on abnormal head-up tilt table (HUTT). METHODS: In a cohort of juvenile patients with neurocardiogenic syncope and dysautonomia documented by abnormal HUTT, biogenic amine metabolites of dopamine and serotonin were quantitated in 18 patients (15 females). HUTT testing is an effective clinical method to evaluate posturally induced physiological events in patients suspected of neurocardiogenic syncope with dysautonomia. RESULTS: Levels of the dopamine metabolite (homovanillic acid: HVA) and/or the serotonin metabolite (5-hydroxyindoleacetic acid: 5HIAA) were significantly reduced in 13 patients compared to age-matched controls. INTERPRETATION: Peripheral biogenic amines and their metabolites have been extensively studied in adults with dysautonomia due to various neurodegenerative disorders (Parkinson disease, multiple system atrophy, primary autonomic failure). Our findings indicate that more than two-thirds of this cohort of young patients with dysautonomia of variable severity have a defect in cerebral biogenic amines, particularly in dopamine and serotonin metabolism. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1501 [Cu] Class update date: 150117 [Lr] Last revision date: 150117 [Da] Date of entry for processing: 150115 [St] Status: PubMed-not-MEDLINE [do] DOI: 10.1002/acn3.49

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[PMID]: 25241803 [Au] Autor: Shaw P; Sudre G; Wharton A; Weingart D; Sharp W; Sarlls J [Ad] Address: 1] Section on Neurobehavioral Clinical Research, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA [2] Intramural Program of the National Institute of Mental Health, Bethesda, MD, USA.... [Ti] Title: White matter microstructure and the variable adult outcome of childhood attention deficit hyperactivity disorder. [So] Source: Neuropsychopharmacology;40(3):746-54, 2015 Feb. [Is] ISSN: 1740-634X [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Changes in cerebral cortical anatomy have been tied to the clinical course of attention deficit hyperactivity disorder (ADHD). We now ask if alterations in white matter tract microstructure are likewise linked with the adult outcome of childhood ADHD. Seventy-five young adults, 32 with ADHD persisting from childhood and 43 with symptom remission were contrasted against 74 never-affected comparison subjects. Using diffusion tensor imaging, we defined fractional anisotropy, a metric related to white matter microstructure, along with measures of diffusion perpendicular (radial) and parallel (axial) to the axon. Analyses were adjusted for head motion, age and sex, and controlled for multiple comparisons and medication history. Tract-based analyses showed that greater adult inattention, but not hyperactivity-impulsivity, was associated with significantly lower fractional anisotropy in the left uncinate (standardized ß=-0.37, t=3.28, p=0.002) and inferior fronto-occipital fasciculi (standardized ß=-0.37, t=3.29, p=0.002). The ADHD group with symptoms persisting into adulthood had significantly lower fractional anisotropy than the never-affected controls in these tracts, differences associated with medium to large effect sizes. By contrast, the ADHD group that remitted by adulthood did not differ significantly from controls. The anomalies were found in tracts that connect components of neural systems pertinent to ADHD, such as attention control (inferior fronto-occipital fasciculus) and emotion regulation and the processing of reward (the uncinate fasciculus). Change in radial rather than axial diffusivity was the primary driver of this effect, suggesting pathophysiological processes including altered myelination as future targets for pharmacological and behavioral interventions. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1501 [Cu] Class update date: 150117 [Lr] Last revision date: 150117 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1038/npp.2014.241

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