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[PMID]: 25430939 [Au] Autor: Lizarraga I; Castillo-Alcala F; Varner KM; Robinson LS [Ad] Address: Department of Biomedical Sciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts and Nevis.... [Ti] Title: Sedation and mechanical antinociception after intravenous administration of detomidine in donkeys: a dosage-effect study. [So] Source: Vet Rec;176(8):202, 2015 Feb 21. [Is] ISSN: 2042-7670 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: There is limited, useful, scientific information on detomidine in donkeys. This study compared the effects of intravenous saline, detomidine (10, 13.5, 17 and 20 µg/kg) and acepromazine (50 µg/kg) in donkeys by computing areas under the curve for 0-30, 30-60 and 60-120 minutes (AUC0-30, AUC30-60 and AUC60-120) for sedation scores, head heights and mechanical nociceptive thresholds (MNTs). For sedation scores, all detomidine treatments, except 10 µg/kg, increased AUC0-30 values compared with saline, and AUC0-30 values were larger for 17 µg/kg detomidine than for acepromazine. All head height AUC values were lower for detomidine than for saline (except AUC60-120 for 10 µg/kg detomidine) and acepromazine (except AUC0-30 for 10 and 20 µg/kg detomidine, and AUC60-120 for 10 µg/kg detomidine). For MNTs, all detomidine treatments increased AUC0-30 and AUC30-60 values compared with saline and acepromazine; AUC30-60 values were smaller for 10 µg/kg than for 17 and 20 µg/kg detomidine. MNT AUC60-120 values were larger for 20 µg/kg detomidine than for saline, 10 µg/kg detomidine and acepromazine. Detomidine induced sedation and antinociception, but only antinociception was dosage dependent. Selection of detomidine dosage for donkeys may depend on the required duration of sedation and/or degree of analgesia. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1502 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1136/vr.102569

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[PMID]: 25698272 [Au] Autor: Karakan T; Cengiz M; Ibis M; Akyürek N; Ünal S [Ad] Address: Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey. drmustafacen@gmail.com. [Ti] Title: Pancreatic metastasis in a case of small cell lung carcinoma diagnosed by EUS. [So] Source: Turk J Gastroenterol;26(1):53-5, 2015 Jan. [Is] ISSN: 1300-4948 [Cp] Country of publication: Turkey [La] Language: eng [Ab] Abstract: Small-cell lung carcinoma represents a group of highly malignant tumors characterized by early and widespread metastais even at the time of diagnosis. However, the pancreas is a relatively infrequent site of metastasis by this neoplasm. A 57-year-old patient was admitted with an intense cough and complaints of abdominal discomfort. A chest X-Ray showed no evidence of lung mass but did show signs of lymphadenopathy. In addition, there was little evidence for malignancy based on a transbronchial needle aspiration. In contrast, there was a mass in the head portion of the pancreas. We diagnosed a case of small-cell lung carcinoma metastasis in the pancreas by using an endoscopic ultrasound-guided fine-needle aspiration biopsy. This case demonstrates that endoscopic ultrasound-guided fine-needle aspiration biopsy is an important tool in the diagnosis of metastatic pancreatic neoplasms. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1502 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.5152/tjg.2015.3687

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[PMID]: 25697618 [Au] Autor: Morovic I CG; Vidal T C; Leiva V N; Véliz M S [Ti] Title: Malformación linfática facial mixta: Caso clínico. [Mixed facial lymphatic malformation: Case report]. [So] Source: Rev Chil Pediatr;85(6):714-9, 2014 Dec. [Is] ISSN: 0717-6228 [Cp] Country of publication: Chile [La] Language: spa [Ab] Abstract: UNLABELLED: Lymphangiomas are a common form of vascular malformation of the lymphatic vessels, mainly in the head and neck region. Most cases are progressive evolution and require a multidisciplinary approach. Currently, the first therapeutic option is sclerotherapy, leaving surgery for the treatment of remaining lesions. OBJECTIVE: To present a case of facial lymphatic malformation (LM) treated with sclerotherapy, surgery and orthodontics in a 15-year follow up. CASE REPORT: A one-year-old female patient who consulted health professionals due to a progressive volume increase of the soft parts of her right cheek. The imaging study confirmed the diagnosis of microcystic lymphatic malformation. It was managed with OK-432 sclerotherapy and Bleomycin. At 2 years of age, the patient response was considered adequate; an intralesional submandibular surgical excision was then performed, with partial resection of the lesion. The biopsy confirmed the diagnosis of microcystic LM. Six months after, a re-resection was planned using the same approach and removing the remaining lesion, with favorable development until the age of 9 years when the patient required surgery and orthodontic management due to intraoral recurrence. No major developments until the age of 13 when a new orthodontic surgery and handling are planned to perform right oral commissure suspension. CONCLUSION: LM management by sclerotherapy, surgery, and orthodontics has shown the advantages of a multidisciplinary long-term treatment in this case. [Pt] Publication type: ENGLISH ABSTRACT; JOURNAL ARTICLE [Em] Entry month: 1502 [Js] Journal subset: IM [St] Status: In-Data-Review

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[PMID]: 25697248 [Au] Autor: Gazmuri B P; Arriaza T B; Castro S F; González N P; Maripan V K; Saavedra R I [Ti] Title: Estudio epidemiológico de la Pediculosis en escuelas básicas del extremo norte de Chile. [Epidemiological study of Pediculosis in elementary schools of Arica, northern Chile]. [So] Source: Rev Chil Pediatr;85(3):312-8, 2014 Jun. [Is] ISSN: 0717-6228 [Cp] Country of publication: Chile [La] Language: spa [Ab] Abstract: UNLABELLED: Pediculosis is an ectoparasitosis infestation that has not received much attention in northern Chile despite it is a common reoccurring condition among school-age children. The objective of this study is to determine the prevalence of Pediculus humanus capitis infestation in elementary schools of Arica. PATIENTS AND METHOD: A group of 665 elementary school students from the Province of Arica were screened between August and November 2010; 467 children who met the inclusion criteria were selected. After parents and students signed an informed consent, the diagnosis was carried out through examination of the head with naked eye in each participating school, recording the presence of Pediculus humanus capitis, infestation level and parasite stage. RESULTS: 40.3% (188) of the children presented Pediculosis; the six schools studied were affected. Pediculosis infestation in girls reached 55.2% (138/250) and 23% (50/217) in boys. CONCLUSION: The school population of Arica is significantly affected by Pediculosis and its prevalence is similar to other regions. [Pt] Publication type: ENGLISH ABSTRACT; JOURNAL ARTICLE [Em] Entry month: 1502 [Js] Journal subset: IM [St] Status: In-Data-Review

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[PMID]: 25410552 [Au] Autor: Herman R; Hirschl RB; Ehrlich PF [Ad] Address: Section of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School, The C.S. Mott Children's Hospital, 4-495 Mott Children's Hospital, 1540 Hopsital drive, Ann Arbor, MI, 48109, USA. [Ti] Title: Sledding injuries a practice-based study is it time to raise awareness? [So] Source: Pediatr Surg Int;31(3):237-40, 2015 Mar. [Is] ISSN: 1437-9813 [Cp] Country of publication: Germany [La] Language: eng [Ab] Abstract: BACKGROUND: The purpose of this review is to describe our practice-based incidence of sledding injuries in children. METHODS: An 8-year (2003-2011) retrospective review of all hospitalized children (<18 years) from a level one pediatric trauma center due to sledding injuries was performed. Demographic, injury severity score (ISS), hospital stay, ICU stay, and discharge status were analyzed and compared to all other trauma hospitalizations. RESULTS: Fifty-two children were hospitalized from sledding injuries. There were 34 males and 18 females with an average age of 10.1 ± 3.7 years. Impact with a tree was the most common mechanism of injury in 33/52 (63.5 %). Strikingly 20 (37 %) patients suffered a head injury with average ISS scores of 13.21 ± 2.30 and 70 % of them were admitted to the ICU. Three children had permanent disability including cognitive impairment and two others required long-term hospitalization rehabilitation. Other injuries included fractures (17), solid organs (10), chest trauma (1), and vertebral fractures (3). CONCLUSIONS: Sledding was a significant component of hospitalized children during winter months. 30 % suffered significant head inquires and nearly 10 % had permanent disabilities. Injury control strategies ensuring safe environments away from trees, and head protection should be publicized. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1502 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1007/s00383-014-3639-y

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[PMID]: 25398259 [Au] Autor: Sakazaki S; Masutani S; Sugimoto M; Tamura M; Kuwata S; Kurishima C; Saiki H; Iwamoto Y; Ishido H; Senzaki H [Ad] Address: Division of Pediatric Cardiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, 350-8550, Japan. [Ti] Title: Oxygen supply to the fetal cerebral circulation in hypoplastic left heart syndrome: a simulation study based on the theoretical models of fetal circulation. [So] Source: Pediatr Cardiol;36(3):677-84, 2015 Mar. [Is] ISSN: 1432-1971 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Hypoxia due to congenital heart diseases (CHDs) adversely affects brain development during the fetal period. Head circumference at birth is closely associated with neuropsychiatric development, and it is considerably smaller in newborns with hypoplastic left heart syndrome (HLHS) than in normal newborns. We performed simulation studies on newborns with CHD to evaluate the cerebral circulation during the fetal period. The oxygen saturation of cerebral blood flow in newborns with CHD was simulated according to a model for normal fetal circulation in late pregnancy. We compared the oxygen saturation of cerebral blood flow between newborns with tricuspid atresia (TA; a disease showing univentricular circulation and hypoplasia of the right ventricle), those with transposition of the great arteries (TGA; a disease showing abnormal mixing of arterial and venous blood), and those with HLHS. The oxygen saturation of cerebral blood flow in newborns with normal circulation was 75.7 %, whereas it was low (49.5 %) in both newborns with HLHS and those with TA. Although the oxygen level is affected by the blood flow through the foramen ovale, the oxygen saturation in newborns with TGA was even lower (43.2 %). These data, together with previous reports, suggest that the cerebral blood flow rate is decreased in newborns with HLHS, and the main cause was strongly suspected to be retrograde cerebral perfusion through a patent ductus arteriosus. This study provides important information about the neurodevelopmental prognosis of newborns with HLHS and suggests the need to identify strategies to resolve this unfavorable cerebral circulatory state in utero. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1502 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1007/s00246-014-1064-6

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[PMID]: 25695832 [Au] Autor: Kiss B; László JF; Szalai A; Pórszász R [Ad] Address: Department of Biophysics and Radiation Biology and MTA-SE Molecular Biophysics Research Group, Semmelweis University, Budapest, Hungary.... [Ti] Title: Analysis of the effect of locally applied inhomogeneous static magnetic field-exposure on mouse ear edema - a double blind study. [So] Source: PLoS One;10(2):e0118089, 2015. [Is] ISSN: 1932-6203 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: The effect static magnetic field (SMF)-exposure may exert on edema development has been investigated. A 6 h long whole-body (WBSMF) or local (LSMF), continuous, inhomogeneous SMF-exposure was applied on anesthetized mice in an in vivo model of mustard oil (MO)-induced ear edema. LSMF was applied below the treated ear, below the lumbar spine, or below the mandible. Ear thickness (v) was checked 8 times during the exposure period (at 0, 0.25, 1, 2, 3, 4, 5, and 6 h). The effect size of the applied treatment (η) on ear thickness was calculated by the formula η = 100% × (1-vj/vi), where group i is the control group and j is the treated group. Results showed that MO treatment in itself induced a significant ear edema with an effect of 9% (p<0.001). WBSMF or LSMF on the spine in combination with MO treatment increased ear thickness even further resulting in an effect of η>11% in both cases compared to SMF-exposure alone (p<0.001). In these cases SMF-exposure alone without MO treatment reduced ear thickness significantly (p<0.05), but within estimated experimental error. In cases of LSMF-exposure on the head, a significant SMF-exposure induced ear thickness reduction was found (η = 5%, p<0.05). LSMF-exposure on the spine affected ear thickness with and without MO treatment almost identically, which provides evidence that the place of local SMF action may be in the lower spinal region. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1502 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1371/journal.pone.0118089

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[PMID]: 25582115 [Au] Autor: Righi S; Boffano P; Guglielmi V; Rossi P; Martorina M [Ad] Address: Division of Otolaryngology, Maxillofacial Surgery and Dentistry, Aosta Hospital, Aosta, Italy. [Ti] Title: Diagnosis and imaging of orbital roof fractures: a review of the current literature. [So] Source: Oral Maxillofac Surg;19(1):1-4, 2015 Mar. [Is] ISSN: 1865-1569 [Cp] Country of publication: Germany [La] Language: eng [Ab] Abstract: Isolated adult orbital roof fractures are uncommon, and the majority of them are typically associated with extensive craniofacial, ophthalmologic, and other body injuries. It is crucial to make an appropriate diagnosis of orbital roof fracture if present. Therefore, the aim of this article was to review the current literature about diagnosis and imaging of orbital roof fracture to obtain current indications. A systematic review of articles published between January 1990 and August 2013 was performed. Early diagnosis of orbital roof fractures can reduce the incidences of intracranial and ocular complications. CT scan still plays a major role in the assessment of acute orbital trauma. Careful assessment and reporting of the CT scan findings are important. In fact, the clinicians managing the patient with acute head and facial trauma should be familiar with the common findings of CT scan in case of an orbital roof fracture. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1502 [Js] Journal subset: D; IM [St] Status: In-Data-Review [do] DOI: 10.1007/s10006-015-0482-9

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[PMID]: 25640075 [Au] Autor: Lenschow C; Brecht M [Ad] Address: Bernstein Center for Computational Neuroscience, Humboldt University of Berlin, Philippstraße 13, 10115 Berlin, Germany. [Ti] Title: Barrel cortex membrane potential dynamics in social touch. [So] Source: Neuron;85(4):718-25, 2015 Feb 18. [Is] ISSN: 1097-4199 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: The impact of social stimuli on the membrane potential dynamics of barrel cortex neurons is unknown. We obtained in vivo whole-cell recordings in the barrel cortex of head-restrained rats while they interacted with conspecifics. Social touch was associated with a depolarization and large membrane potential fluctuations locked to the rat's whisking. Both depolarization and membrane potential fluctuations were already observed prior to contact and did not occur during free whisking. This anticipatory pre-contact depolarization was not seen in passive social touch in anesthetized animals. The membrane potential fluctuations locked to the rat's whisking observed in interactions with awake conspecifics were larger than those seen for whisking onto nonconspecific stimuli (stuffed rats, objects, and the experimenter's hand). Responses did not correlate with whisker movement parameters. We conclude that responses to social touch differ from conventional tactile responses in (1) amplitude, (2) locking to whisking, and (3) pre-contact membrane potential changes. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1502 [Js] Journal subset: IM [St] Status: In-Data-Review

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[PMID]: 25698327 [Au] Autor: Zhang Q; Tiefenbacher K [Ad] Address: Department Chemie, Technische Universität München, Lichtenbergstraße 4, D-85747 Garching, Germany. [Ti] Title: Terpene cyclization catalysed inside a self-assembled cavity. [So] Source: Nat Chem;7(3):197-202, 2015 Mar. [Is] ISSN: 1755-4349 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: In nature, complex terpene natural products are formed by the so-called tail-to-head terpene (THT) cyclization. The cationic reaction cascade is promoted efficiently in complex enzyme pockets, in which cationic intermediates and transition states are stabilized. In solution, the reaction is hard to control and man-made catalysts able to perform selective THT cyclizations are lacking. We herein report the first example of a successful THT cyclization inside a supramolecular structure. The basic mode of operation in cyclase enzymes was mimicked successfully and a catalytic non-stop THT was achieved with geranyl acetate as the substrate. The results presented have implications for the postulated reaction mechanism in cyclase enzymes. Evidence indicates that the direct isomerization of a geranyl cation to the cisoid isomer, which so far was considered unlikely, is feasible. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1502 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1038/nchem.2181

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