Database : MEDLINE
Search on : hemangioendothelioma [Words]
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[PMID]: 29377717
[Au] Autor:Haller J; David MP; Lee NE; Shalin SC; Gardner JM
[Ti] Title:Impact of Pathologist Involvement in Sarcoma and Rare Tumor Patient Support Groups on Facebook: A Survey of 542 Patients and Family Members.
[So] Source:Arch Pathol Lab Med;, 2018 Jan 29.
[Is] ISSN:1543-2165
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CONTEXT: - Patients with rare tumors have difficulty finding reliable information about their disease. Facebook patient support groups allow patients to educate one another. OBJECTIVE: - To investigate how these patients perceive the value of pathologists, both in Facebook groups and real-world patient care. DESIGN: - Survey links were posted in 12 Facebook patient groups: 6 with an active pathologist member (angiosarcoma, epithelioid hemangioendothelioma, epithelioid sarcoma, dermatofibrosarcoma protuberans [×2], and desmoid fibromatosis), and 6 without "active" pathologist involvement (aggressive angiomyxoma, chondrosarcoma, Ewing sarcoma, leiomyosarcoma, liposarcoma, and osteosarcoma). RESULTS: - A total of 542 people responded (403 were patients): 264 from groups with a pathologist, and 278 from groups without active pathologist involvement. Of groups with an active pathologist, respondents agreed the pathologist's posts helped them better understand their disease (107 of 119; 90%) and relieved some of their disease-related anxiety (92 of 119; 77%). And for these groups 98% (117 of 119) of respondents agreed that having a pathologist in their group was a good thing; 83% (192 of 232) wanted more pathologists involved. More respondents from groups with an active pathologist (219 of 236; 93%) than without one (215 of 252; 85%) agreed: "pathologists are an important part of the patient care team for patients with cancer and other rare tumors" ( P = .008). CONCLUSIONS: - This study is the first to evaluate the impact of pathologist interaction with Facebook patient support groups and to assess perceptions about the specialty of pathology from a large group of patients with rare tumors. Pathologist involvement in Facebook patient groups appears to positively influence patient perception of the importance of pathologists. We hope these data will encourage more pathologists to participate in Facebook patient support groups.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.5858/arpa.2017-0408-OA

  2 / 3840 MEDLINE  
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[PMID]: 29511030
[Au] Autor:van IJzendoorn DGP; Sleijfer S; Gelderblom H; Eskens FALM; van Leenders GJ; Szuhai K; Bovee JVMG
[Ad] Address:Pathology, Leiden University Medical Center.
[Ti] Title:Telatinib is an effective targeted therapy for pseudomyogenic hemangioendothelioma.
[So] Source:Clin Cancer Res;, 2018 Mar 06.
[Is] ISSN:1078-0432
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Pseudomyogenic hemangioendothelioma (PHE) is an extremely rare locally aggressive neoplasm with endothelial differentiation, which often presents with multiple lesions. These tumors have characteristic SERPINE1-FOSB fusions. We report a 17 years old patient with advanced unresectable PHE with a durable complete remission to the multi-tyrosine kinase inhibitor telatinib. The aim of this study was to generate an in vitro model for PHE, to study the functional consequences of SERPINE1-FOSB in endothelial cells, and its interaction with telatinib, to biologically substantiate the complete response to telatinib. EXPERIMENTAL DESIGN: As the fusion results in overexpression of a truncated form of FOSB, we overexpressed truncated FOSB in normal endothelial cells. RESULTS: Truncated FOSB significantly affected tumor growth in 3D on matrigel with increased and sustained sprouting. Moreover, truncated FOSB acted as an active transcription factor capable to regulate its own transcription, as well as to upregulate PDGFRA and FLT1 expression (4-fold). Telatinib decreased proliferation and tumor growth in 3D and induced apoptosis. As expected, telatinib blocked VEGF signaling as phosphorylation of ERK was abolished. Interestingly, in FOSB overexpressing cells, telatinib specifically affected PDGFRA, FLT1 and FLT4 signaling and down-regulated SERPINE1, thereby affecting the self-regulation of the fusion gene. CONCLUSIONS: We provide a biological substantiation of a complete clinical remission that was seen in a patient with PHE, showing that telatinib indirectly interferes with the self-regulated expression of the fusion product. Thus, telatinib or any other currently available VEGFR1-4/PDGFRA inhibitor, could be a highly specific treatment option for patients with multifocal unresectable PHE.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher

  3 / 3840 MEDLINE  
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[PMID]: 29503064
[Au] Autor:Moyano-Rodríguez MJ; Quero-Valenzuela F
[Ad] Address:Departamento de Cirugía Torácica, Hospital Universitario Virgen de las Nieves, Granada, España. Electronic address: mj1989kul@gmail.com.
[Ti] Title:Hemangioendotelioma cérvico-mediastínico gigante de la vena subclavia. Giant Cervical and Mediastinal Hemangioendothelioma Arising from Subclavian Vein.
[So] Source:Arch Bronconeumol;, 2018 Mar 01.
[Is] ISSN:1579-2129
[Cp] Country of publication:Spain
[La] Language:eng; spa
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher

  4 / 3840 MEDLINE  
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[PMID]: 29476440
[Au] Autor:Rimondi E; Mavrogenis AF; Errani C; Calabrò T; Bazzocchi A; Facchini G; Donatiello S; Spinnato P; Vanel D; Albisinni U; Pelotti P
[Ad] Address:Department of Diagnostic and Interventional Radiology, Istituto Ortopedico Rizzoli, Bologna, Italy.
[Ti] Title:Biopsy is not necessary for the diagnosis of soft tissue hemangiomas.
[So] Source:Radiol Med;, 2018 Feb 23.
[Is] ISSN:1826-6983
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To describe the clinical and ultrasonography (US) findings of soft tissue hemangiomas, and to compare with the results of histologic diagnosis after US-guided biopsy. METHOD AND MATERIALS: We retrospectively studied the files of 97 patients (48 female, 49 male; mean age, 34 years; range 4-84 years) with soft tissue hemangiomas diagnosed from 2004 to 2011. Mean follow-up was 9 years (range 7-13 years). Clinical presentation included intermittent mild pain associated with a soft tissue swelling/palpable mass in all patients, chronic pain and increased local heat in 29 patients, local swelling and decreased range of motion of the adjacent joint in 45 patients, and all the above symptoms in 23 patients. B-mode and color Doppler US evaluation included the site, location, size, shape, margins, presence of calcifications, echo structure and echogenicity. All patients had US-guided biopsy for histologic analysis. RESULTS: US-guided biopsy and histology confirmed the diagnosis of soft tissue hemangioma in 92 of the 97 lesions (94.8%). Histologic examination of the remaining five lesions showed nodular fasciitis (two lesions), endometriosis (one lesion), hemangioendothelioma (two lesions); US of these lesions showed variable size, irregular margins, and deep-seated location. Histologically documented soft tissue hemangiomas were most commonly superficial (74 lesions) and arteriovenous (45 lesions). Shape was most commonly oval (fusiform), margins were most commonly not well defined (irregular, hazing but circumscribed), phleboliths were more common in deep-seated lesions, echo structure was heterogeneous, and echogenicity was most commonly hyperechogen and involuting. CONCLUSION: Clinical presentation and typical B-mode and color Doppler US findings are adequate for the diagnosis of soft tissue hemangiomas without the need for biopsy and histologic analysis. If any clinical or US doubt, an US-guided biopsy should be performed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180224
[Lr] Last revision date:180224
[St] Status:Publisher
[do] DOI:10.1007/s11547-018-0862-y

  5 / 3840 MEDLINE  
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[PMID]: 29453774
[Au] Autor:Wang Y; Han H; Du Y
[Ad] Address:Department of Gastroenterology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
[Ti] Title:Hobnail (Retiform-Dabska) Hemangioendothelioma located in Jejunum.
[So] Source:Dig Endosc;, 2018 Feb 17.
[Is] ISSN:1443-1661
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:A 27-year-old man referred to our department with a 1-month history of intermittent melena and dizziness. Gastroscopy and colonoscopy did not identify the site of bleeding. Laboratory data showed hemoglobin 6.6g/dL. Video capsule endoscopy (CE, Anhon,China) and antegrade double-ballon enteroscopy (DBE, EN450P5, Fujinon, Japan) were carried out and a space occupying lesion in the proximal jejunum was identified (Fig.1). Ink tattooing via DBE was performed to mark the site of the tumor.Then the patient underwent jejunectomy. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180217
[Lr] Last revision date:180217
[St] Status:Publisher
[do] DOI:10.1111/den.13040

  6 / 3840 MEDLINE  
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[PMID]: 29415297
[Au] Autor:Ganss F; Theurer R; Zorger N
[Ti] Title:Epitheloides Hämangioendotheliom der Leber: Typische Merkmale in der MR-Bildgebung. [Hepatic epithelioid hemangioendothelioma: Characteristic signs in MRI].
[So] Source:Rofo;, 2018 Feb 07.
[Is] ISSN:1438-9010
[Cp] Country of publication:Germany
[La] Language:ger
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:Publisher
[do] DOI:10.1055/s-0044-100730

  7 / 3840 MEDLINE  
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[PMID]: 29355969
[Au] Autor:Konstantinidis IT; Nota C; Jutric Z; Ituarte P; Chow W; Chu P; Singh G; Warner SG; Melstrom LG; Fong Y
[Ad] Address:Department of Surgical Oncology, City of Hope National Medical Center, Duarte, California.
[Ti] Title:Primary liver sarcomas in the modern era: Resection or transplantation?
[So] Source:J Surg Oncol;, 2018 Jan 22.
[Is] ISSN:1096-9098
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND AND OBJECTIVES: Primary liver sarcomas (PLS) are rare. Published series are limited by small numbers of patients. METHODS: We reviewed the National Cancer Database (2004-2014) for patients who underwent surgical resection of PLS. RESULTS: Of 237 patients identified, the majority were female (60.8%), with median age of 52 years. Histologies were: epithelioid hemangioendothelioma (n = 67), angiosarcoma (n = 64), leiomyosarcoma (n = 33), embryonal rhabdomyosarcoma (n = 31), carcinosarcoma (n = 16), giant cell sarcoma (n = 14), spindle cell sarcoma (n = 12). Ninety-seven (40.9%) patients underwent lobectomies or extended lobectomies, 41 patients (17.3%) underwent transplantation. Surgical margins were negative in 82.9%. Tumors were well differentiated in 11.3%. Histology type correlated with outcome with the best prognosis for epithelioid hemangioendothelioma (OS: not reached, similar for resection and transplantation) and the worst for angiosarcoma (OS:16.6 mo with resection; 6 mo with transplantation; P = 0.04). Resections with microscopically negative margins were associated with improved survival (58.7 vs 11.3 mo for positive margins; P < 0.001). Chemotherapy and radiation therapy were used in a minority of patients (32.9% and 4.3% respectively) with no improvement in outcomes. CONCLUSIONS: Both hepatic resection and liver transplantation can be associated with long term survival for selected primary liver sarcomas such as epitheliod hemangioendotheliomas. Histology type and the ability to resect the tumor with negative margins correlate with outcomes and the decision to operate should be carefully weighed for subtypes with particularly dismal prognosis such as angiosarcomas.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:Publisher
[do] DOI:10.1002/jso.24979

  8 / 3840 MEDLINE  
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[PMID]: 29406432
[Au] Autor:Raftopoulos E; Royer M; Warren M; Zhao J; Rush W
[Ad] Address:Department of Pathology, Womack Army Medical Center, Fort Bragg, NC.
[Ti] Title:Pseudomyogenic Hemangioendothelioma: Case Report and Review of the Literature.
[So] Source:Am J Dermatopathol;, 2018 Feb 02.
[Is] ISSN:1533-0311
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Pseudomyogenic hemangioendothelioma (PHE; epithelioid sarcoma-like hemangioendothelioma) is a rare entity, with 129 reported cases. It is a rarely metastasizing, low-grade vascular tumor that can histologically mimic epithelioid sarcoma and often presents as multiple discontinuous nodules in the extremities. PHEs characteristically and consistently show immunoreactivity for cytokeratins and endothelial markers. We present a case in the thigh of a 65-year-old-man with a 3-month history of painful lesions in the dermis and review the published literature. In our case, the lesion exhibited the characteristic histologic findings and immunoprofile of a PHE: a solid proliferation of spindled to epithelioid cells with abundant eosinophilic cytoplasm and frequent rhabdoid cells. Cytologic atypia and mitotic figures were inconspicuous. The tumor cells were immunoreactive for CD31, ERG, AE1/3, and CK7 and negative for D2-40, P53, HMB45, desmin, CD34, SMA, EMA, and S100 protein. A balanced reciprocal translation between chromosomes 7 and 19 was present; this translocation seems unique to PHE. PHE is a unique and commonly misdiagnosed entity; therefore, we review the literature to describe the characteristics of this tumor.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180206
[Lr] Last revision date:180206
[St] Status:Publisher
[do] DOI:10.1097/DAD.0000000000001104

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[PMID]: 29373279
[Au] Autor:Elleuch N; Dahmani W; Aida Ben S; Jaziri H; Aya H; Ksiaa M; Jmaa A
[Ad] Address:Hospital Sahloul, Department of gastroenterology, Sahloul, 2002 Soussa, Tunisia. Electronic address: elleuchghorbel.nour@yahoo.fr.
[Ti] Title:Hepatic epithelioid hemangioendothelioma: A misdiagnosed rare liver tumor.
[So] Source:Presse Med;, 2018 Jan 17.
[Is] ISSN:2213-0276
[Cp] Country of publication:France
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1801
[Cu] Class update date: 180203
[Lr] Last revision date:180203
[St] Status:Publisher

  10 / 3840 MEDLINE  
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[PMID]: 29388191
[Au] Autor:Zhang G; Chen H; Gao Y; Liu Y; Wang J; Liu XY
[Ad] Address:Department of Dermatology and Venereology, Capital Institute of Pediatrics, Beijing, China.
[Ti] Title:Sirolimus for treatment of Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon: A retrospective cohort study.
[So] Source:Br J Dermatol;, 2018 Feb 01.
[Is] ISSN:1365-2133
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Kaposiform hemangioendothelima (KHE) is a locally aggressive vascular tumor that mainly occurs during childhood and invades adjacent tissue and organ. It is commonly complicated by Kasabach-Merritt phenomenon (KMP) in about 50%-70% of the cases. KMP is most often associated with a rapidly growing, large solitary tumor that may result in severe hemorrhage and directly responsible for high mortality and morbidity. This article is protected by copyright. All rights reserved.
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180201
[Lr] Last revision date:180201
[St] Status:Publisher
[do] DOI:10.1111/bjd.16400


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