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[PMID]: 29524707
[Au] Autor:Nishimura F; Park YS; Motoyama Y; Nakagawa I; Yamada S; Nakase H
[Ad] Address:Department of Neurosurgery, Nara Medical University, Nara, Japan. Electronic address: fnishi@naramed-u.ac.jp.
[Ti] Title:Pediatric case of xanthogranuloma in sellar region presenting visual disturbance successfully treated by endoscopic endonasal surgery.
[So] Source:World Neurosurg;, 2018 Mar 07.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Xanthomatous pituitary diseases rarely occur in childhood. We report a rare pediatric case of a xanthogranuloma that developed in the sellar region resulting in visual disturbance that was successfully treated by endoscopic endonasal surgery. CASE DESCRIPTIONS: A 13-year-old boy came to us with a headache and visual disturbance that had occurred 1 month prior. Clinical examination findings showed that he was alert with signs of bitemporal hemianopsia, an endocrinological examination showed partial hypopituitarism, and brain magnetic resonance imaging (MRI) revealed a cystic mass in the sellar turcica compressing the optic apparatus. Endoscopic endonasal surgery was performed to decompress the optic apparatus and the mass was removed. Histopathological analysis of the tumor demonstrated granulomatous tissue with cholesterol clefts, foamy macrophages, and multinucleated giant cells, with no epithelial component. The diagnosis was xanthogranuloma of the sellar region. The patient gradually recovered from visual disturbance and was free from any neurological symptom 6 months after surgery. CONCLUSIONS: Xanthogranuloma, although rare, should be considered as a differential diagnosis of a sellar/suprasellar lesion even in children.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 3163 MEDLINE  
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[PMID]: 29342484
[Au] Autor:Rohrschneider K
[Ad] Address:Univ.-Augenklinik Heidelberg Ophthalmologische Rehabilitation.
[Ti] Title:Fahreignung aus (neuro)ophthalmologischer Sicht. [(Neuro-)ophthalmogical aspects of driving ability].
[So] Source:Fortschr Neurol Psychiatr;86(1):28-36, 2018 01.
[Is] ISSN:1439-3522
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:The requirements regarding visual functioning needed for driving ability are stipulated in Annex 6 of the German driving licence regulations: In case of a visual disorder an ophthalmological assessment is essential: It is of crucial importance for the examining ophthalmologist to exhaust all ocular-medical possibilities to enable the applicant to maintain or regain his driving permission. In the overwhelming majority of the cases this is eminently feasible.However, there is no way to attest driving ability in a patient suffering acute one-sided visual loss for a period of 3 months on the basis of legal recommendations. Concerning oculomotor disturbances, the expansion of the diplopic central visual field and the subjective restriction caused thereby are important: the central 20 degree area must be free of diplopia.According to the German driving license regulations, absolute homonymous visual field defects such as hemianopsia or quadrantic defects affecting the visual centre are incompatible with driving an automobile. Even training measures causing the patient to experience a sense of smooth orientation do nothing to mitigate this fact.Dealing with serious disturbances of visual function, as a matter of principle an ophthalmologist should provide an additional expertise before a positive decision on driving ability is made.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process
[do] DOI:10.1055/s-0043-122676

  3 / 3163 MEDLINE  
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[PMID]: 29197090
[Au] Autor:Moavero R; Papetti L; Tarantino S; Battan B; Salfa I; Deodati A; Schiaffini R; Vigevano F; Valeriani M
[Ad] Address:Child Neurology Unit, Neuroscience and Neurorehabilitation Department, Bambino Gesù Children's Hospital, Headache Center, IRCCS, Rome, Italy.
[Ti] Title:Syndrome of Transient Headache and Neurologic Deficits With Cerebrospinal Fluid Lymphocitosis Should Be Considered in Children Presenting With Acute Confusional State.
[So] Source:Headache;58(3):438-442, 2018 Mar.
[Is] ISSN:1526-4610
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL) is benign and self-limited, with neurologic deficits including sensory disturbance of one body side, aphasia, nausea/vomiting, weakness, decreased vision, homonymous hemianopsia, photophobia. Acute confusional state can rarely occur. Papilledema and intracranial hypertension have also been described. It is a rare entity mainly affecting adults; however, it has been sporadically described in children and adolescents. MAIN FINDINGS: In this clinical observational study, we describe a clinical series of three consecutive pediatric patients being diagnosed with HaNDL after presenting with altered consciousness, papilledema, and increased intracranial pressure. They all recovered without relapses. CONCLUSION: Presentation during childhood and adolescence is rare; the majority of pediatric cases presented with altered consciousness, which is infrequent in HaNDL. This may suggest that in childhood this symptom might be more common than in adults. All three patients presented with increased intracranial pressure and papilledema, thus suggesting that these aspects should be investigated in all patients presenting with this clinical pattern. Finally, all our patients began to suffer from migraine. This feature, together with the benign course of the disease, could favor the hypothesis of a migrainous pathophysiology of this syndrome, although this remains a speculative.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Data-Review
[do] DOI:10.1111/head.13238

  4 / 3163 MEDLINE  
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[PMID]: 29449735
[Au] Autor:Mengoli MC; Bertolini F; Maur M; Barbieri F; Longo L; Gasparri P; Tiseo M; Rossi G
[Ad] Address:Unit of Pathology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
[Ti] Title:ALK-positive adenocarcinoma of the lung expressing neuroendocrine markers and presenting as a "pituitary adenoma".
[So] Source:Pathologica;109(4):408-411, 2017 Dec.
[Is] ISSN:0031-2983
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:We report an ALK-rearranged adenocarcinoma of the lung presenting as a pituitary metastasis, clinically simulating a pituitary adenoma. The patient, a 50 year-old, former-smoking woman was admitted with a Parinaud's syndrome characterized by progressive oculomotor impairment of visual verticality, bitemporal hemianopsia and nystagmus. Imaging studies showed a sellar tumor and the biopsy revealed a TTF-1 and napsin positive lung adenocarcinoma strongly expressing synaptophysin and CD56, also harboring ALK rearrangement. A subsequent CT scan disclosed the primary lung mass of the left upper lobe. The patient progressed after 4 cycles of cisplatin/pemetrexed as first line treatment, but showed a partial response and a significant clinical benefit from the combination of ceritinib and nivolumab in a phase Ib trial. Despite its central nervous system tropism, ALK-rearranged adenocarcinoma manifesting with pituitary gland involvement was never reported. Second generation ALK inhibitors seem the best therapeutic strategy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:In-Data-Review

  5 / 3163 MEDLINE  
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[PMID]: 29429784
[Au] Autor:Lenk J; Engellandt K; Terai N; Bottesi A; Matthé E
[Ad] Address:Department of Ophthalmology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany. Electronic address: Janine.Lenk@uniklinikum-dresden.de.
[Ti] Title:Rapid progressive visual decline and visual field defects in two patients with the Heidenhain variant of Creutzfeld-Jakob disease.
[So] Source:J Clin Neurosci;, 2018 Feb 08.
[Is] ISSN:1532-2653
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Heidenhain variant of Creutzfeldt-Jakob (HvCJD) is a rare disease, patients presenting with loss of visual acuity and a decline in visual fields. CASE PRESENTATION: Two patients with rapid loss of visual acuity and declining visual fields presented with homonymic hemianopsia over several weeks. Cranial MRI showed neither stroke nor other morphological changes explaining the severe visual field defects. Neurological examination revealed no pathologies. However, lumbar puncture showed an increase in total protein in cerebrospinal fluid (CSF). Visual field testing revealed further deterioration during follow-up. Several weeks later, patients' behaviour changed markedly, exhibiting aggression, declining memory function and physical degeneration. The suspected diagnosis was the Heidenhain variant of Creutzfeld-Jakob disease (HvCJD). CSF analysis showed evidence of PrP and 14-3-3 protein. Both patients died within 8 weeks of the CJD diagnosis. CONCLUSIONS: Loss of visual acuity and a decline in visual fields without corresponding MRI findings and marked changes in behaviour should lead to a diagnosis of HvCJD. Corresponding diagnostic tests should be performed for confirmation. The prognosis for survival is poor and should be immediately communicated to affected patients and their relatives.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:Publisher

  6 / 3163 MEDLINE  
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[PMID]: 29421446
[Au] Autor:In-Ping Huang Cobb M; Mintz-Cole R; Husain AM; Berger M; Jang D; Codd P
[Ad] Address:Department of Neurosurgery, Duke University Hospitals. Electronic address: maryih.cobb@duke.edu.
[Ti] Title:Transnasal transphenoidal elevation of optic chiasm in secondary empty sella syndrome following prolactinoma treatment.
[So] Source:World Neurosurg;, 2018 Feb 05.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Prolactinomas are typically treated non-surgically with a dopamine agonist. However, once the tumor shrinks, adjacent eloquent structures such as the optic apparatus can become skeletonized and herniate into the dilated parasellar space. CASE DESCRIPTION: We describe here a 48-year-old man with a prolactin-secreting macroadenoma treated with cabergoline who presented with progressive bitemporal hemianopsia. MRI showed no recurrence of disease and a stretched optic chiasm herniating into an empty sella. He underwent a transnasal transphenoidal approach elevation of the optic chiasm with an alloderm graft and septal cartilage strut. He was discharged home the next day with significant improvement in his vision and an MRI showing interval elevation of the optic chiasm. CONCLUSIONS: We review here secondary empty sella syndrome and discuss surgical strategies for optic chiasmapexy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher

  7 / 3163 MEDLINE  
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[PMID]: 25815856
[Au] Autor:de Haan GA; Heutink J; Melis-Dankers BJ; Brouwer WH; Tucha O
[Ad] Address:Department of Clinical and Developmental Neuropsychology (GAdH, JH, WHB, OT), University of Groningen, Groningen, the Netherlands; Department of Rehabilitation & Advice (GAdH, JH, BJMM-D), Royal Dutch Visio, Centre of Expertise for Blind and Partially Sighted People, Haren, the Netherlands; and Department of Neurology (WHB), University Medical Center Groningen, Groningen, the Netherlands.
[Ti] Title:Difficulties in Daily Life Reported by Patients With Homonymous Visual Field Defects.
[So] Source:J Neuroophthalmol;35(3):259-64, 2015 Sep.
[Is] ISSN:1536-5166
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Homonymous visual field defects (HVFD) are common after postchiasmatic acquired brain injury and may have a significant impact on independent living and participation in society. Vision-related difficulties experienced in daily life are usually assessed using questionnaires. The current study 1) links the content of 3 of these questionnaires to the International Classification of Functioning, Disability and Health (ICF) and 2) provides analyses of vision-related difficulties reported by patients with HVFD and minimal comorbidities. METHODS: Fifty-four patients with homonymous hemianopia or quadrantanopia were asked about difficulties experienced in daily life because of their HVFD. This was performed during a structured interview including 3 standardized questionnaires: National Eye Institute Visual Functioning Questionnaire, Independent Mobility Questionnaire, and Cerebral Visual Disorders Questionnaire. The reported difficulties were linked to the ICF according to the ICF linking rules. Main outcome measures were presence or absence of experienced difficulties. RESULTS: The ICF linking procedure resulted in a classification table that can be used in future studies of vision-related difficulties. Besides well-known difficulties related to reading, orientation, and mobility, a high proportion of patients with HVFD reported problems that previously have not been documented in the literature, such as impaired light sensitivity, color vision, and perception of depth. CONCLUSIONS: A systematic inventory of difficulties experienced in daily life by patients with HVFD was performed using the ICF. These findings have implications for future study, assessment and rehabilitation of patients with HVFD.
[Mh] MeSH terms primary: Activities of Daily Living/psychology
Disability Evaluation
Hemianopsia/physiopathology
Hemianopsia/psychology
Visual Fields/physiology
[Mh] MeSH terms secundary: Color Vision
Depth Perception
Female
Humans
Male
Surveys and Questionnaires
Visual Field Tests
[Pt] Publication type:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Entry month:1606
[Cu] Class update date: 180116
[Lr] Last revision date:180116
[Js] Journal subset:IM
[Da] Date of entry for processing:150328
[St] Status:MEDLINE
[do] DOI:10.1097/WNO.0000000000000244

  8 / 3163 MEDLINE  
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[PMID]: 29330070
[Au] Autor:Webb K; Osorio M
[Ad] Address:Resident, Rehabilitation Medicine, University of Washington, Box 356490 Room BB938, 1959 NE Pacific Street Seattle, WA 98195. Electronic address: kaliwebb@uw.edu.
[Ti] Title:Neutropenia as a Complication of Tumefactive Demyelinating Disease: A Case Report.
[So] Source:PM R;, 2018 Jan 09.
[Is] ISSN:1934-1563
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Tumefactive demyelination is an aggressive, localized, generally solitary area of demyelination that often mimics a neoplasm. We present a case of a 13-year-old female who presented with sudden onset, progressive hemiplegia and hemianopsia. Brain magnetic resonance imaging showed tumefactive demyelination with partial rim of enhancement. During inpatient rehabilitation, she developed myalgias, rash, abdominal and mouth pain with evidence for severe neutropenia. The neutropenia was determined to be a secondary complication of the tumefactive disease process. This scenario may be concerning in an inpatient rehabilitation setting as patients share common areas, increasing the risk of acquired infection while neutropenic.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180113
[Lr] Last revision date:180113
[St] Status:Publisher

  9 / 3163 MEDLINE  
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[PMID]: 29274021
[Au] Autor:Kim TG; Jin KH; Kang J
[Ad] Address:Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, # 892, Dongnam-ro, Gangdong-gu, Seoul, 05278, Republic of Korea.
[Ti] Title:Clinical characteristics and ophthalmologic findings of pituitary adenoma in Korean patients.
[So] Source:Int Ophthalmol;, 2017 Dec 22.
[Is] ISSN:1573-2630
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:PURPOSE: To investigate the clinical characteristics of and ophthalmic findings in Korean patients diagnosed with a pituitary adenoma. METHODS: The medical records of 534 patients diagnosed with a pituitary adenoma at Kyung Hee University Hospital between January 2007 and December 2016 were retrospectively reviewed. RESULTS: Mean patient age was 47.9 ± 16.2 years. The most common symptoms at the time of presentation were headache (26.2%) and visual disturbance (12.4%). The referral rate to the ophthalmology department was 18.44% and patients most often presented to the neurosurgery department. Optic chiasm compression was identified in 23.4% of patients (54.4% of patients referred to ophthalmology, 15.0% of patients not referred to ophthalmology). Normal visual field (57%) was the most common visual field feature followed by bitemporal hemianopsia (17.8%). Optic chiasmal compression without visual field defects was found in 36.1% of patients. Tumor volume was positively correlated with visual field pattern standard deviation (PSD, p = 0.020) and best-corrected logMAR visual acuity (p = 0.000) and negatively associated with tumor volume and visual field mean deviation (MD, p = 0.000). Best-corrected visual acuity (p = 0.000), MD (p = 0.001), and PSD (p = 0.028) significantly improved after surgery. CONCLUSIONS: Pituitary adenoma patients do not always have ocular symptoms at their first presentation, even when optic chiasm compression and visual field deficits are present. Therefore, collaboration with an ophthalmologist is important when evaluating pituitary adenoma patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171223
[Lr] Last revision date:171223
[St] Status:Publisher
[do] DOI:10.1007/s10792-017-0778-x

  10 / 3163 MEDLINE  
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[PMID]: 29152467
[Au] Autor:Kim JW; Nam TK; Park KS; Park YS; Kwon JT
[Ad] Address:Department of Neurosurgery, Chung-Ang University Hospital, Seoul, Korea.
[Ti] Title:An Unruptured Anterior Communicating Artery Aneurysm Presenting with Left Homonymous Hemianopsia: A Case Report.
[So] Source:J Cerebrovasc Endovasc Neurosurg;19(2):92-95, 2017 Jun.
[Is] ISSN:2234-8565
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Unruptured cerebral aneurysms sometimes present with visual symptomsdue to compression of the visual pathways. However, until now, unruptured anterior communicating artery (ACoA) aneurysms presenting visual field defects have been extremely rare. The authors report the case of a 51-year-old woman who presented with left homonymous hemianopsia. Radiological findings demonstrated an ACoA aneurysm filled with thrombus, that was compressing the optic chiasm and post-chiasmal tract. The patient underwent clipping of the aneurysm, which resolved the visual field defect. In cases of visual field defects, an ACoA aneurysm should be included in the differential diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171122
[Lr] Last revision date:171122
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.7461/jcen.2017.19.2.92


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