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Carneiro, M
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[PMID]: 29363152
[Au] Autor:Rodrigues Oliveira JL; Teixeira MM; Lambertucci JR; Antunes CMF; Carneiro M; Negrão-Corrêa D
[Ad] Address:Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
[Ti] Title:Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni-infected individuals.
[So] Source:Scand J Immunol;87(3), 2018 Mar.
[Is] ISSN:1365-3083
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In the murine model, it was demonstrated that pro-inflammatory cytokines and chemokines are essential to the formation and modulation of Schistosoma-induced granulomatous inflammation. However, the relationship of these immune mediators and disease severity is hard to be established in naturally infected individuals. The current study evaluates the association between plasma concentrations of MIF, sTNF-R1, CCL3, CCL7 and CCL24 and schistosomiasis morbidity in Schistosoma mansoni-infected patients with a low parasite burden. For this propose, 97 S. mansoni-infected individuals were subjected to abdominal ultrasound analysis and clinical examination. Among them, 88 had plasma concentration of immune mediators estimated by ELISA assay. Multivariate linear regression models were used to evaluate the relationship between the plasma concentration of immune mediators and the variables investigated. Although most individuals presented low parasite burden, over 30% of them showed signs of fibrosis defined by ultrasound measurements and 2 patients had a severe form of schistosomiasis. No association between parasite burden and the plasma levels of chemokine/cytokines or disease severity was observed. There was a positive association between plasma concentration of CCL4, sTNF-R1, CCL3 and MIF with gall bladder thickness and/or with portal vein thickness that are liver fibrosis markers. In contrast, no association was found between CCL7 plasma concentrations with any of the schistosomiasis morbidity parameters evaluated. The data showed that CCL24, sTNFR1, MIF and CCL3 can be detected in plasma of S. mansoni-infected individuals and their concentration would be used as prognostic makers of Schistosoma-induced liver fibrosis, even in individuals with low parasite burden.
[Mh] MeSH terms primary: Chemokine CCL24/blood
Chemokine CCL3/blood
Chemokine CCL7/blood
Intramolecular Oxidoreductases/blood
Liver Cirrhosis/immunology
Macrophage Migration-Inhibitory Factors/blood
Receptors, Tumor Necrosis Factor, Type I/blood
Schistosoma mansoni/immunology
Schistosomiasis mansoni/immunology
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Animals
Humans
Liver/blood supply
Liver/parasitology
Liver/pathology
Liver Cirrhosis/parasitology
Middle Aged
Portal Vein/pathology
Schistosomiasis mansoni/parasitology
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (CCL24 protein, human); 0 (CCL3 protein, human); 0 (CCL7 protein, human); 0 (Chemokine CCL24); 0 (Chemokine CCL3); 0 (Chemokine CCL7); 0 (Macrophage Migration-Inhibitory Factors); 0 (Receptors, Tumor Necrosis Factor, Type I); 0 (TNFRSF1A protein, human); EC 5.3.- (Intramolecular Oxidoreductases); EC 5.3.2.1 (MIF protein, human)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180125
[St] Status:MEDLINE
[do] DOI:10.1111/sji.12642

  2 / 20791 MEDLINE  
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[PMID]: 29340920
[Au] Autor:Kim JH
[Ad] Address:Department of Surgery, Eulji University College of Medicine, Daejeon, Republic of Korea. asist10@hanmail.net.
[Ti] Title:Pure Laparoscopic Transhepatic Enucleation of a Mucinous Cystic Neoplasm Abutting the Major Hepatic Veins at the Hepatocaval Confluence (with Video).
[So] Source:J Gastrointest Surg;22(3):557, 2018 Mar.
[Is] ISSN:1873-4626
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: A mucinous cystic neoplasm (MCN) of the liver is a rare disease entity, occurring predominantly in the left hemiliver as reported by Simo et al.1 Thomas et al.2 and Vogt et al.3 Surgical resection of tumors at the hepatocaval confluence is a technically demanding procedure. Enucleation procedures have been performed for the management of benign or premalignant lesions such as cystic tumors as previously described by Thomas et al.2 and Vogt et al.3. We present a patient who underwent pure laparoscopic transhepatic enucleation to treat a MCN abutting the major hepatic veins at the hepatocaval confluence. METHODS: We treated a 77-year-old man who presented with a 5-cm-sized cystic mass at the hepatocaval confluence. Using the Pringle maneuver, we performed liver parenchymal transection along the junction between the origin of the middle hepatic vein (MHV) and the inferior vena cava (IVC) as reported by Kim4. The MHV formed the left-sided boundary of the cystic mass. After dissection of the left boundary of the cystic wall, the dorsal side of the cystic mass was carefully dissected. Liver parenchymal transection was continued up to the right hepatic vein (RHV). Laparoscopic enucleation was performed to expose the RHV and MHV, as well as the IVC. RESULTS: The operation time was 270 min, the estimated blood loss was 80 mL, and no transfusion was necessary in this patient. The final histopathological diagnosis of the mass was MCN. Postoperatively, the patient recovered uneventfully, and he was discharged on postoperative day 5. CONCLUSIONS: Laparoscopic transhepatic enucleation for MCNs at the hepatocaval confluence is technically feasible and offers the benefits of a parenchyma-sparing resection. However, this procedure requires a high level of technical skills and shows a steep learning curve.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1007/s11605-018-3677-1

  3 / 20791 MEDLINE  
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[PMID]: 29513180
[Au] Autor:Ibrahimi S; Mroué AA; Francois E; Jagodzinski R
[Ti] Title:Jaundice in a pregnant woman.
[So] Source:Acta Gastroenterol Belg;80(3):422-424, 2017 Jul-Sep.
[Is] ISSN:1784-3227
[Cp] Country of publication:Belgium
[La] Language:eng
[Ab] Abstract:A 34-year-old woman in the 22nd week of gestation presented with generalized pruritis and weight loss since the first trimester of pregnancy. Physical examination revealed cutaneous scratch lesions, jaundice, and hepatomegaly. Blood tests revealed cholestasis with elevated direct bilirubinemia. Auto-antibody and viral hepatitis tests were negative. Liver ultrasound was normal. The initial diagnosis was cholestasis of pregnancy. However despite treatment with ursodeoxycholic acid, the patient did not improve. Delivery was by cesarean section at the 26th week of pregnancy for obstetrical reasons. A new liver ultrasound showed a heterogeneous nodular mass. Nuclear magnetic resonance (NMR) of the liver showed an 11-cm mass centered on the hilum, dilated intrahepatic bile ducts, involvement of the hepatic veins, and hilar adenopathy. A liver biopsy revealed fibrolamellar hepatocellular carcinoma (FHC).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

  4 / 20791 MEDLINE  
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[PMID]: 29499671
[Au] Autor:Fahrner R; Rauchfuss F; Scheuerlein H; Settmacher U
[Ad] Address:University Hospital Jena, Division of General, Visceral and Vascular Surgery, Am Klinikum 1, 07740, Jena, Germany.
[Ti] Title:Posttraumatic venous gas in the liver - a case report and review of the current literature.
[So] Source:BMC Surg;18(1):14, 2018 Mar 02.
[Is] ISSN:1471-2482
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: There are numerous causes of hepatic gas formation that range from serious pathologies to incidental findings, including mesenteric infarction, liver abscess, inflammatory bowel disease or minimally invasive hepatic interventions. CASE PRESENTATION: We report a case of a 50-year-old man who was admitted to the emergency room after a car accident. The clinical examination and further diagnostics revealed a craniocerebral injury with a fracture of the skull, concomitant soft tissue lesions and subarachnoidal bleeding. Furthermore, a blunt thoracic trauma with hemopneumothorax due to rib fractures was treated with a chest tube. No obvious abdominal pathology was seen. While in the operating theatre for the surgical revision of the cranial soft tissue lesions, a femoral venous catheter was inserted without any complications. A routine ultrasound of the abdomen six hours after the trauma revealed unclear hepatic gas formation. A contrast-enhanced computer tomography (CT) scan of the abdomen was performed, and the gas formation was found to be localized within the left hepatic vein. Afterwards, there was no specific treatment of the hepatic venous gas formation, as no alterations of liver function or liver enzymes were seen. The further course of the patient was uneventful regarding the gas formation in the liver, and another ultrasound two days later revealed no further gas in the liver. CONCLUSIONS: The placement of a femoral venous catheter is a risk factor for gas formation in liver veins. No further treatment is needed in cases with stable liver function. To rule out serious pathologies, diagnostic findings (e.g., ultrasound, CT), clinical history and underlying diseases need to be analyzed carefully after the detection of intrahepatic gas formation. With contrast-enhanced CT, the localization of the gas and its potential causes might be detectable.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1186/s12893-018-0345-z

  5 / 20791 MEDLINE  
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[PMID]: 29501311
[Au] Autor:Plaza OA; Moreno F
[Ad] Address:National Institute of Legal Medicine and Forensic Sciences, Cali, Colombia. Electronic address: oscarplazap33@hotmail.com.
[Ti] Title:Anatomical variations of the thymus in relation to the left brachiocephalic vein, findings of necropsia.
[So] Source:Int J Pediatr Otorhinolaryngol;107:53-55, 2018 Apr.
[Is] ISSN:1872-8464
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Two cases of anatomical variations of the thymus are presented with respect to the anatomical relations with the left brachiocephalic vein and found during the necropsy process. Less than 2 days after birth with Noonan Syndrome, when the left brachiocephalic vein was scanning behind the upper thymus horns, there were other adjacent lesions consisting of three supernumerary spleens and three hepatic veins. The second case was an 8-year-old infant with child malpractice who died from urinary sepsis due to obstructive uropathy, in which case the upper lobes of the thymus were fused and formed a ring through which the left brachiocephalic vein passed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Process

  6 / 20791 MEDLINE  
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[PMID]: 29428370
[Au] Autor:Farhat A; Ali-Deeb E; Sulaiman A; Aljamali M
[Ad] Address:Department of Biochemistry and Microbiology, School of Pharmacy, Damascus University, Damascus, Syria. Electronic address: arwa.farhat1@gmail.com.
[Ti] Title:Reinforcing the utility of chick embryo model to in vivo evaluate engraftment of human leukemic stem cells.
[So] Source:J Egypt Natl Canc Inst;30(1):1-5, 2018 Mar.
[Is] ISSN:1110-0362
[Cp] Country of publication:Egypt
[La] Language:eng
[Ab] Abstract:BACKGROUND AND OBJECTIVE: Development of appropriate translational in vivo models is a prerequisite for personalized management of leukemic patients. Indeed, several immunodeficient mice models were developed for leukemias with main limitations due to their high cost, demanding management, and elongated assessment intervals. In this report, we aimed at evaluating the engraftment of CD34 cells, isolated from an acute myeloid leukemia (AML) patient, in naturally immunodeficient chick embryo model. METHODS AND RESULTS: Mononuclear cells or immunomagnetic sorted CD34 cells were injected into chick embryo chorioallantoic membrane (CAM) veins. Seven days post-injection, human CD34 transcript was detected by reverse transcription polymerase chain reaction (RT-PCR) in blood, bone marrow (BM), spleen and liver from embryos injected with human leukemic cells. Interestingly, an amplicon of the same length has been detected in both BM and spleen from PBS injected embryos, although analysis via bioinformatics tools revealed no matches in chicken; neither in transcriptome nor in genome databases. Importantly, splenomegaly and hepatic lesions were observed in some CD34 cells injected embryos. CONCLUSION: Collectively, our data confirm the engraftment of primary human CD34 leukemic cells in chick embryo liver, but other experiments are required to verify engraftment in BM and spleen, and to confirm the identity of a putative CD34 orthologous transcript in these two organs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Process

  7 / 20791 MEDLINE  
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[PMID]: 29316476
[Au] Autor:Cheng D; Zhuang Y; Kou Q; Zhang M; Zhao Y; Han C; Li J; Wang Y; Xu K; Mo F; Zhang J
[Ad] Address:School of Information and Control Engineering, China University of Mining and Technology, Xuzhou 221116, China.
[Ti] Title:Numerical simulation of hemodynamics in membranous obstruction of the suprahepatic inferior vena cava based on a subject-specific Budd-Chiari syndrome model.
[So] Source:Clin Biomech (Bristol, Avon);52:20-24, 2018 Feb.
[Is] ISSN:1879-1271
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: This study was performed to determine the hemodynamic changes of Budd-Chiari syndrome when the inferior vena vein membrane is developing. METHODS: A patient-specific Budd-Chiari syndrome vascular model was reconstructed based on magnetic resonance images using Mimics software and different degrees (16%, 37%, and 54%) of idealized membrane were built based on the Budd-Chiari syndrome vascular model using Geomagic software. Three membrane obstruction Budd-Chiari syndrome vascular models were established successfully and fluent software was used to simulate hemodynamic parameters, including blood velocity and wall shear stress. FINDINGS: The simulation results showed that there is low velocity and a low wall shear stress region at the junction of the inferior vena cava and the branches of the hepatic veins, and swirl may occur in this area. As the membrane develops, the size of the low velocity and low wall shear stress regions enlarged and the wall shear stress was increased at the membrane region. There was a significant difference in the mean values of wall shear stress between the different obstruction membrane models (P<0.05). INTERPRETATION: Hemodynamic parameters play an important role in vascular disease and there may be a correlation between inferior vena cava wall shear force changes and the slow development process of the inferior vena cava membrane.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:In-Data-Review

  8 / 20791 MEDLINE  
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[PMID]: 29207378
[Au] Autor:Akkiz H; Carr BI; Yalçin K K; Guerra V; Kuran S; Altintas E; Üsküdar O; Karaogullarindan Ü; Özakyol A; Tokmak S; Yücesoy M; Bahçeci HI; Ülkü A; Akçam T; Yalçin Polat K; Ekinci N; Simsek H; Örmeci N; Sonsuz A; Demir M; Kiliç M; Uygun A; Balli T; Demir A; Arslan B; Doran F
[Ad] Address:Gastroenterology Department, Çukurova Üniversitesi, Adana, Turkey.
[Ti] Title:Characteristics of Hepatocellular Carcinoma Aggressiveness Factors in Turkish Patients.
[So] Source:Oncology;94(2):116-124, 2018.
[Is] ISSN:1423-0232
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:A large cohort of hepatocellular carcinoma (HCC) patients from several collaborating Turkish institutions were examined for the tumor parameters of maximum diameter (MTD), portal vein thrombosis (PVT), and α-fetoprotein (AFP) levels. A relationship was found between MTD and blood platelet levels. Patients with large ≥5 cm tumors who had normal platelet levels had significantly larger tumors, higher percent of PVT, and significantly lower blood total bilirubin and liver cirrhosis than similar ≥5 cm tumor patients having thrombocytopenia. A comparison of patients with and without PVT showed significantly larger tumors, greater multifocality, blood AFP, and C-reactive protein levels, and, interestingly, lower HDL levels in the patients with PVT. Fifty-eight percent of the total cohort had AFP levels ≤100 IU/mL (and 42.1% had values ≤20 IU/mL). These patients had significantly smaller tumors, less tumor multifocality and percent PVT, lower total bilirubin, and less cirrhosis. There was considerable geographic heterogeneity within Turkey in the patterns of HCC presentation, with areas of higher and lower hepatitis B virus, hepatitis D virus, cirrhosis, and tumor aggressiveness parameters. Turkish patients thus have distinct patterns of presentation, but the biological relationships between MTD and both platelets and bilirubin levels are similar to the relationships that have been reported in other ethnic patient groups.
[Mh] MeSH terms primary: Carcinoma, Hepatocellular/pathology
Liver Neoplasms/pathology
[Mh] MeSH terms secundary: Bilirubin/blood
Biomarkers, Tumor/blood
Blood Platelets/pathology
C-Reactive Protein/metabolism
Carcinoma, Hepatocellular/blood
Carcinoma, Hepatocellular/metabolism
Female
Humans
Liver Cirrhosis/blood
Liver Cirrhosis/metabolism
Liver Cirrhosis/pathology
Liver Function Tests/methods
Liver Neoplasms/blood
Liver Neoplasms/metabolism
Male
Middle Aged
Portal Vein/pathology
Prognosis
Prospective Studies
Thrombocytopenia/blood
Thrombocytopenia/metabolism
Thrombocytopenia/pathology
Turkey
Venous Thrombosis/blood
Venous Thrombosis/metabolism
Venous Thrombosis/pathology
alpha-Fetoproteins/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers, Tumor); 0 (alpha-Fetoproteins); 9007-41-4 (C-Reactive Protein); RFM9X3LJ49 (Bilirubin)
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Js] Journal subset:IM
[Da] Date of entry for processing:171206
[St] Status:MEDLINE
[do] DOI:10.1159/000484564

  9 / 20791 MEDLINE  
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[PMID]: 29496081
[Au] Autor:Bargiela D; Verkerk MM; Wee I; Welman K; Ng E; Choong AMTL
[Ad] Address:SingVaSC, Singapore Vascular Surgical Collaborative, Singapore; Department of Physiology, Development and Neuroscience, University of Cambridge, UK.
[Ti] Title:The endovascular management of neurofibromatosis-associated aneurysms: A systematic review.
[So] Source:Eur J Radiol;100:66-75, 2018 Mar.
[Is] ISSN:1872-7727
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Neurofibroblastoma (NF) or Von Recklinghausen disease, is an autosomal dominant disorder affecting one in 3000 individuals. Cardinal features of NF include multiple café-au-lait macules, benign neurofibromas, and iris hamartomas. Albeit less common, vascular lesions of medium and large-sized arteries and veins are a well-recognized complication, which can lead to fatal consequences such as rupture. METHOD: A systematic review was conducted as per the Preferred Reporting Instructions for Systematic Reviews and Meta-analysis (PRISMA) guidelines utilizing PubMed, EMBASE, and Cochrane databases. RESULTS: There were 59 articles identified involving 66 patients (mean age 44.3 ±â€¯30 years), of which 89% had neurofibromatosis type 1. There were 63.6% of patients who presented with aneurysm rupture, 33.3% presented with intact symptomatic aneurysms, and 3.1% presented with intact asymptomatic aneurysms. Anatomically, 4.5% of patients suffered from intracranial aneurysms; 12.1% suffered from visceral artery aneurysms (including hepatic, superior mesenteric, gastroduodenal and renal arteries), and other patients suffered from aneurysms within the chest, abdomen, pelvis, upper limbs and neck. Amongst the various endovascular procedures, coiling was performed in 83.3% of cases. There were 12 covered stents employed in 10 patients (18.2%), of which 7 were balloon-expandable grafts; 2 were self-expandable graft; 3 were not mentioned. The rates of major and minor complications were 15% and 6% respectively, with 4 cases (6%) of perioperative death. On a mean follow-up of 15 months (range 1.5-72 months), two patients developed a distant vascular lesion from the treated lesion. CONCLUSION: Endovascular management is safe and effective even in hemodynamically unstable neurofibroblastoma patients at all ages. Vascular tree screening should be conducted in clinically suspicious patients to prevent fatal aneurysmal complications. A formal meta-analysis could not be performed due to the lack of randomized controlled trials.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  10 / 20791 MEDLINE  
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[PMID]: 29309776
[Au] Autor:Verhelst X; Geerts A; Jochmans I; Vanderschaeghe D; Paradissis A; Vanlander A; Berrevoet F; Dahlqvuist G; Nevens F; Pirenne J; Rogiers X; Callewaert N; Troisi RI; Van Vlierberghe H
[Ad] Address:Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium; Experimental Laboratory of Hepatology, Ghent University, Ghent, Belgium.
[Ti] Title:Glycome Patterns of Perfusate in Livers Before Transplantation Associate With Primary Nonfunction.
[So] Source:Gastroenterology;, 2018 Jan 06.
[Is] ISSN:1528-0012
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND & AIMS: Primary nonfunction (PNF) is a rare complication after liver transplantation that requires urgent retransplantation. PNF is associated with livers from extended criteria donors. Clinical and biochemical factors have not been identified that reliably associate with graft function after liver transplantation. Serum patterns of N-glycans associate with changes in the liver. We analyzed perfusate from grafted liver to identify protein glycosylation patterns associated with PNF. METHODS: We performed a prospective study of consecutive patients who underwent liver transplantation (66 patients, from 1 center, in the derivation set, and 56 patients, from 2 centers, in the validation set) in Belgium, from October 1, 2011, through July 31, 2013. All donor grafts were transported using cold static storage, and perfusate samples were collected from the livers by flushing of hepatic veins before transplantation. Protein-linked N-glycans were isolated from perfusate samples and analyzed with a multicapillary electrophoresis-based ABI3130 sequencer. We compared glycan patterns between patients with vs without PNF of transplanted livers. PNF was defined as the need for urgent retransplantation when a graft had no evidence of function, after exclusion of other causes, such as hepatic artery thrombosis or acute cellular rejection. RESULTS: The relative abundance of a single glycan, agalacto core-alpha-1,6-fucosylated biantennary glycan (NGA2F) was significantly increased in perfusate of livers given to 4 patients who developed PNF after liver transplantation compared with livers given to patients who did not develop PNF. Level of NGA2F identified patients with PNF with 100% accuracy. This glycomarker was the only factor associated with PNF in multivariate analysis in the derivation and the validation sets (P < .0001). CONCLUSIONS: In an analysis of patients who underwent liver transplantation, we associated graft perfusate level of the glycosylated protein NGA2F with development of PNF with 100% accuracy, and validated this finding in a separate cohort of patients. This biomarker might be used to assess grafts before transplantation, especially when high-risk organs are under consideration.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher


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