Database : MEDLINE
Search on : herpes and labialis [Words]
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[PMID]: 29269697
[Au] Autor:Himeno T; Shiga Y; Takeshima S; Tachiyama K; Kamimura T; Kono R; Takemaru M; Takeshita J; Shimoe Y; Kuriyama M
[Ad] Address:Department of Neurology, Brain Attack Center, Ota Memorial Hospital.
[Ti] Title:[Clinical, epidemiological, and etiological studies of adult aseptic meningitis: a report of 12 cases of herpes simplex meningitis, and a comparison with cases of herpes simplex encephalitis].
[So] Source:Rinsho Shinkeigaku;58(1):1-8, 2018 Jan 26.
[Is] ISSN:1882-0654
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:We treated 437 cases of adult aseptic meningitis and 12 cases (including 2 recurrent patients; age, 31.8 ± 8.9 years; 7 females) of herpes simplex meningitis from 2004 to 2016. The incidence rate of adult herpes simplex meningitis in the cases with aseptic meningitis was 2.7%. One patient was admitted during treatment of genital herpes, but no association was observed between genital herpes and herpes simplex meningitis in the other cases. The diagnoses were confirmed in all cases as the cerebrospinal fluid (CSF) was positive for herpes simplex virus (HSV)-DNA. For diagnosis confirmation, the DNA test was useful after 2-7 days following initial disease onset. Among other types of aseptic meningitis, the patients with herpes simplex meningitis showed relatively high white blood cell counts and relatively high CSF protein and high CSF cell counts. CSF cells showed mononuclear cell dominance from the initial stage of the disease. During same period, we also experienced 12 cases of herpes simplex encephalitis and 21 cases of non-hepatic acute limbic encephalitis. Notably, the patients with herpes simplex meningitis were younger and their CSF protein and cells counts were higher than those of the patients with herpes simplex encephalitis.
[Mh] MeSH terms primary: Encephalitis, Herpes Simplex
Herpes Simplex
Meningitis, Viral
[Mh] MeSH terms secundary: Adolescent
Adult
Age Factors
Biomarkers/cerebrospinal fluid
Cell Count
Cerebrospinal Fluid/cytology
Cerebrospinal Fluid Proteins/cerebrospinal fluid
DNA, Viral/cerebrospinal fluid
Encephalitis, Herpes Simplex/cerebrospinal fluid
Encephalitis, Herpes Simplex/diagnosis
Encephalitis, Herpes Simplex/epidemiology
Encephalitis, Herpes Simplex/virology
Female
Humans
Male
Meningitis, Viral/cerebrospinal fluid
Meningitis, Viral/diagnosis
Meningitis, Viral/epidemiology
Meningitis, Viral/virology
Middle Aged
Simplexvirus/genetics
Young Adult
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers); 0 (Cerebrospinal Fluid Proteins); 0 (DNA, Viral)
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[Js] Journal subset:IM
[Da] Date of entry for processing:171223
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001098

  2 / 17568 MEDLINE  
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Silveira, Thaís Gomes Verzignassi
Lonardoni, Maria Valdrinez Campana
SciELO Brazil full text

[PMID]: 29451600
[Au] Autor:Oyama J; Ferreira FBP; Conter CC; Lera-Nonose DSSL; Ramos-Milaré ÁCFH; Venazzi EAS; Silveira TGV; Lonardoni MVC
[Ad] Address:Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
[Ti] Title:American tegumentary leishmaniasis: diagnostic and treatment challenges in a clinical case.
[So] Source:Rev Inst Med Trop Sao Paulo;60:e3, 2018.
[Is] ISSN:1678-9946
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:This clinical case presents a patient with a raised and ulcerative lesion with erythematous edges in the mouth, on the lower lip that was unsuccessfully treated as herpes labialis. Clinical data and laboratory tests (Montenegro skin test, indirect immunofluorescence, direct parasite search and polymerase chain reaction) led to the diagnosis of American tegumentary leishmaniasis caused by Leishmania (Viannia) sp. Treatment with pentavalent antimonial (Glucantime®) for 120 days was not effective and administration of amphotericin B for 30 days resulted in wound healing. Glucantime® treatment protocol was longer than the recommended by the Brazilian Ministry of Health in the handbook of mucosal leishmaniasis. This suggests that amphotericin B should have been administered earlier, preventing the psychological and social problems faced by the patient. This study reports a rare clinical case of primary mucosal leishmaniasis on the lip that had a delayed diagnosis, highlighting the precariousness in the management of disease and showing that, despite the importance of leishmaniasis in Brazil, it is still neglected by health professionals.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process

  3 / 17568 MEDLINE  
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[PMID]: 29235378
[Au] Autor:Adorisio S; Fierabracci A; Gigliarelli G; Muscari I; Cannarile L; Liberati AM; Marcotullio MC; Riccardi C; Curini M; Robles Zepeda RE; Delfino DV
[Ad] Address:1 Section of Pharmacology, Department of Medicine, University of Perugia, Perugia, Italy.
[Ti] Title:The Hexane Fraction of Bursera microphylla A. Gray Induces p21-Mediated Anti-Proliferative and Pro-Apoptotic Effects in Human Cancer-Derived Cell Lines.
[So] Source:Integr Cancer Ther;17(1):138-147, 2018 Mar.
[Is] ISSN:1552-695X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Bursera microphylla (BM), one of the common elephant trees, is widely distributed in the Sonoran Desert in Mexico. The Seri ethnic group in the Sonoran Desert uses BM as an anti-inflammatory and painkiller drug for the treatment of sore throat, herpes labialis, abscessed tooth, and wound healing. Dried stems and leaves of BM are used in a tea to relieve painful urination and to stimulate bronchial secretion. Furthermore, BM is used for fighting venereal diseases. To investigate the effects of the hexane fraction of resin methanol extract (BM-H) on cell growth, the acute myeloid cell line (OCI-AML3) was treated with 250, 25, or 2.5 µg/mL of BM-H. The first 2 concentrations were able to significantly decrease OCI-AML3 cell number. This reduced cell number was associated with decreased S-phase, blockade of the G /M phase of the cell cycle, and increased cell death. Similar results were obtained on all tested tumor cell lines of different origins. We found that blockade of the cell cycle was due to upregulation of p21 protein in a p53-independent way. Increase of p21 was possibly due to upstream upregulation of p-ERK (which stabilizes p21 protein) and downregulation of p-38 (which promotes its degradation). Regarding cell death, activation of caspase-3, but not of caspase-8 or -9, was detectable after BM-H treatment. In conclusion, these data suggest that the BM's hexane fraction inhibited proliferation of cell lines mainly by a p21-dependent, p53-independent mechanism and promoted apoptosis through activation of caspase-3, but not caspase-8 or -9.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[St] Status:In-Data-Review
[do] DOI:10.1177/1534735417696721

  4 / 17568 MEDLINE  
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[PMID]: 29437933
[Au] Autor:Stewart SE; Lin JL; Everhart JL; Pham TH; Marqueling AL; Rieger KE; Hilgenberg SL
[Ad] Address:Divisions of General Pediatrics, sarahs12@stanford.edu.
[Ti] Title:Well-Appearing Newborn With a Vesiculobullous Rash at Birth.
[So] Source:Pediatrics;, 2018 Feb 06.
[Is] ISSN:1098-4275
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A term, appropriate-for-gestational-age, male infant born via normal spontaneous vaginal delivery presented at birth with a full-body erythematous, vesiculobullous rash. He was well-appearing with normal vital signs and hypoglycemia that quickly resolved. His father had a history of herpes labialis. His mother had an episode of herpes zoster during pregnancy and a prolonged rupture of membranes that was adequately treated. The patient underwent a sepsis workup, including 2 attempted but unsuccessful lumbar punctures, and was started on broad-spectrum antibiotics and acyclovir, given concerns about bacterial or viral infection. The rash evolved over the course of several days. Subsequent workup, with particular attention to his history and presentation, led to his diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher

  5 / 17568 MEDLINE  
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[PMID]: 28454912
[Au] Autor:Pertusati F; Serafini S; Albadry N; Snoeck R; Andrei G
[Ad] Address:School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, CF10 3NB, Cardiff, Wales, United Kingdom. Electronic address: pertusatif1@cardiff.ac.uk.
[Ti] Title:Phosphonoamidate prodrugs of C5-substituted pyrimidine acyclic nucleosides for antiviral therapy.
[So] Source:Antiviral Res;143:262-268, 2017 07.
[Is] ISSN:1872-9096
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Acyclic nucleoside phosphonates (ANPs) are nowadays one of the key drugs in the treatment of DNA virus and retrovirus infections. In this work, we report the synthesis and antiviral evaluation of phosphonoamidate and diamidates prodrugs of C5-pyrimidine acyclic nucleosides derivatives functionalized with but-2-enyl- chain. In the phosphonoamidate series, the most active compound 15, showed sub-micromolar activity against varicella zoster virus (VZV) (EC = 0.09-0.5 µM) and µM activity against human cytomegalovirus (HCMV) and herpes simplex virus (HSV). Separation of single diastereoisomers for compound 14, showed that 14b had better anti-herpesvirus activity and no cytotoxicity compared to the diastereoisomeric mixture 14. Very interestingly, phosphonodiamidate 21 showed anti-herpesvirus activity with excellent activity against wild type and thymidine kinase-deficient (TK ) VZV strains (EC = 0.47 and 0.2 µM, respectively) and HCMV (EC = 3.5-7.2 µM) without any cytotoxicity (CC > 100).
[Mh] MeSH terms primary: Prodrugs/chemical synthesis
Prodrugs/pharmacology
Pyrimidine Nucleosides/chemical synthesis
Pyrimidine Nucleosides/pharmacology
[Mh] MeSH terms secundary: Antiviral Agents/chemical synthesis
Antiviral Agents/pharmacology
Cell Line
Cytomegalovirus/drug effects
Herpesvirus 3, Human/drug effects
Humans
Simplexvirus/drug effects
Thymidine Kinase
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antiviral Agents); 0 (Prodrugs); 0 (Pyrimidine Nucleosides); EC 2.7.1.21 (Thymidine Kinase)
[Em] Entry month:1712
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[Js] Journal subset:IM
[Da] Date of entry for processing:170430
[St] Status:MEDLINE

  6 / 17568 MEDLINE  
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[PMID]: 28470128
[Au] Autor:Parsons BF; Ryder N
[Ad] Address:1 Pacific Clinic Newcastle, HNE Sexual Health, Newcastle, NSW, Australia.
[Ti] Title:Pseudoepitheliomatous hyperplasia causing a painful plaque in a HIV-infected female.
[So] Source:Int J STD AIDS;28(7):723-725, 2017 06.
[Is] ISSN:1758-1052
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Dermatological conditions are more common and can present atypically, in human immunodeficiency virus-infected individuals. This case report describes a 22-year-old human immunodeficiency virus-positive Caucasian female who presented with a vulval lesion eight weeks after starting antiretroviral treatment. Clinical examination revealed a 2 cm well-demarcated plaque on the outer aspect of the left labium minus. The lesion was tender, no contact bleeding or ulceration present. She was presumptively treated for chancroid and herpes simplex with 500 mg ceftriaxone IM stat, 1 g azithromycin PO stat, and valacyclovir 500 mg BD for five days. The lesion persisted despite treatment, and during follow-up, a punch biopsy was carried out. She was diagnosed with pseudoepitheliomatous hyperplasia of the epidermis. In addition to highlighting this condition that has been previously reported in human immunodeficiency virus/herpes simplex virus co-infection, this case demonstrates that unusual skin presentations must be considered in human immunodeficiency virus-infected individuals and illustrates the importance of biopsy for any non-healing lesions.
[Mh] MeSH terms primary: HIV Infections/complications
Herpes Genitalis/diagnosis
Hyperplasia/pathology
Vulva/pathology
Vulvar Diseases/diagnosis
[Mh] MeSH terms secundary: Adult
Anti-HIV Agents/therapeutic use
Biopsy
Coinfection/virology
Female
HIV Infections/drug therapy
Herpes Genitalis/complications
Herpes Genitalis/drug therapy
Herpes Genitalis/microbiology
Humans
Immunocompromised Host
Simplexvirus
Treatment Outcome
Vulvar Diseases/complications
Vulvar Diseases/drug therapy
Vulvar Diseases/microbiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-HIV Agents)
[Em] Entry month:1712
[Cu] Class update date: 180205
[Lr] Last revision date:180205
[Js] Journal subset:IM; X
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.1177/0956462416676020

  7 / 17568 MEDLINE  
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[PMID]: 28466551
[Au] Autor:Nilsson J; Granrot I; Mattsson J; Omazic B; Uhlin M; Thunberg S
[Ad] Address:Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.
[Ti] Title:Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation.
[So] Source:Vox Sang;112(5):459-468, 2017 Jul.
[Is] ISSN:1423-0410
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND AND OBJECTIVES: Allogeneic hematopoietic stem cell transplantation (HSCT) is a routine clinical procedure performed to treat patients with haematological malignancies, primary immune deficiencies or metabolic disorders. Infections during lymphopenia after allogeneic HSCT are associated with high mortality and morbidity. Typical infectious agents are Epstein-Barr virus, cytomegalovirus, herpes simplex virus, varicella-zoster virus and fungi. The study aim was to evaluate whether measurement of the responses of antigen-specific T-cells, recognizing infectious pathogens would correlate to protective functions in the stem cell recipient post-transplant. MATERIALS AND METHODS: Twenty-one grafts were analysed by flow cytometry and cells were stimulated in vitro with relevant infectious antigens, followed by evaluation of T-cell proliferation and cytokine production. Results were compared to the recipients' clinical records 1-year post-transplantation. RESULTS: We show that an extensive repertoire of transferred antigen-specific T-cells from allogeneic donor grafts against infectious agents, involved in post-transplant infections, are linked to an absence of infectious complications for the recipient up-to 1-year post-transplant. The protective effect was associated with antigen-specific T-cell proliferation and IL-1ß secretion. CONCLUSION: Our results suggest that assaying T-cell function before HSCT could determine individual risks for infectious complications and thus aid in clinical decision-making regarding prophylactic and pre-emptive anti-infective therapy.
[Mh] MeSH terms primary: Hematopoietic Stem Cell Transplantation/adverse effects
Hematopoietic Stem Cells/physiology
Virus Diseases/prevention & control
[Mh] MeSH terms secundary: Adenoviridae/immunology
Adolescent
Adult
Aged
Candida/immunology
Child
Child, Preschool
Cytomegalovirus/immunology
Female
Flow Cytometry
Hematologic Neoplasms/therapy
Herpesvirus 3, Human/immunology
Herpesvirus 4, Human/immunology
Humans
Infant
Infection Control/methods
Leukocyte Count
Lymphocyte Activation
Male
Middle Aged
Simplexvirus/immunology
T-Lymphocytes/immunology
T-Lymphocytes/virology
Transplantation, Homologous/adverse effects
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180201
[Lr] Last revision date:180201
[Js] Journal subset:IM
[Da] Date of entry for processing:170504
[St] Status:MEDLINE
[do] DOI:10.1111/vox.12521

  8 / 17568 MEDLINE  
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[PMID]: 29276548
[Au] Autor:Arenberger P; Arenbergerova M; Hladíková M; Holcova S; Ottillinger B
[Ad] Address:Department of Dermatovenerology, Third Faculty of Medicine, Charles University of Prague, Prague, Czech Republic.
[Ti] Title:Comparative Study with a Lip Balm Containing 0.5% Propolis Special Extract GH 2002 versus 5% Aciclovir Cream in Patients with Herpes Labialis in the Papular/Erythematous Stage: A Single-blind, Randomized, Two-arm Study.
[So] Source:Curr Ther Res Clin Exp;88:1-7, 2018.
[Is] ISSN:0011-393X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Background and objectives: This controlled single-blind trial compared the efficacy of a lip balm with propolis special extract GH 2002 at a concentration of 0.5% in the treatment of episodes of herpes labialis with that of 5% aciclovir cream. Methods: Patients in the erythematous/papular stage were randomized: 189 patients were treated with propolis cream, 190 patients were treated with aciclovir cream (intention-to-treat population). Application was 5 times daily. The primary parameter was the difference in median time to complete encrustation or epithelialization of lesions. Secondary parameters were the development of typical herpes symptoms (eg, pain, burning and itching, tension, and swelling), the global assessment of efficacy, and the safety of application. Results: The predefined clinical situation was reached after a median of 4 days with propolis and after 5 days with aciclovir ( < 0.0001). Significant differences in favor of the study preparation were found with all secondary parameters and symptoms. No allergic reactions, local irritations, or other adverse events were observed. Conclusions: A formulation of 0.5% propolis GH 2002 extract lip balm was found to be superior in the treatment of episodes of herpes labialis over 5% aciclovir cream in patients in the papular/erythematous phase upon inclusion. EudraCT Registration No. 2006-001971-38.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171228
[Lr] Last revision date:171228
[St] Status:In-Data-Review
[do] DOI:10.1016/j.curtheres.2017.10.004

  9 / 17568 MEDLINE  
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[PMID]: 28468883
[Au] Autor:Srivastava R; Khan AA; Chilukuri S; Syed SA; Tran TT; Furness J; Bahraoui E; BenMohamed L
[Ad] Address:Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, California, USA.
[Ti] Title:CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8 T and CD8 T Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease.
[So] Source:J Virol;91(14), 2017 Jul 15.
[Is] ISSN:1098-5514
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Herpes simplex virus 1 (HSV-1) establishes latency within the sensory neurons of the trigeminal ganglia (TG). HSV-specific memory CD8 T cells play a critical role in preventing HSV-1 reactivation from TG and subsequent virus shedding in tears that trigger recurrent corneal herpetic disease. The CXC chemokine ligand 10 (CXCL10)/CXC chemokine receptor 3 (CXCR3) chemokine pathway promotes T cell immunity to many viral pathogens, but its importance in CD8 T cell immunity to recurrent herpes has been poorly elucidated. In this study, we determined how the CXCL10/CXCR3 pathway affects TG- and cornea-resident CD8 T cell responses to recurrent ocular herpesvirus infection and disease using a well-established murine model in which HSV-1 reactivation was induced from latently infected TG by UV-B light. Following UV-B-induced HSV-1 reactivation, a significant increase in both the number and function of HSV-specific CXCR3 CD8 T cells was detected in TG and corneas of protected C57BL/6 (B6) mice, but not in TG and corneas of nonprotected CXCL10 or CXCR3 deficient mice. This increase was associated with a significant reduction in both virus shedding and recurrent corneal herpetic disease. Furthermore, delivery of exogenous CXCL10 chemokine in TG of CXCL10 mice, using the neurotropic adeno-associated virus type 8 (AAV8) vector, boosted the number and function of effector memory CD8 T cells (T ) and tissue-resident memory CD8 T cells (T ), but not of central memory CD8 T cells (T ), locally within TG, and improved protection against recurrent herpesvirus infection and disease in CXCL10 deficient mice. These findings demonstrate that the CXCL10/CXCR3 chemokine pathway is critical in shaping CD8 T cell immunity, locally within latently infected tissues, which protects against recurrent herpesvirus infection and disease. We determined how the CXCL10/CXCR3 pathway affects CD8 T cell responses to recurrent ocular herpesvirus infection and disease. Using a well-established murine model, in which HSV-1 reactivation in latently infected trigeminal ganglia was induced by UV-B light, we demonstrated that lack of either CXCL10 chemokine or its CXCR3 receptor compromised the mobilization of functional CD8 T and CD8 T cells within latently infected trigeminal ganglia following virus reactivation. This lack of T cell mobilization was associated with an increase in recurrent ocular herpesvirus infection and disease. Inversely, augmenting the amount of CXCL10 in trigeminal ganglia of latently infected CXCL10-deficient mice significantly restored the number of local antiviral CD8 T and CD8 T cells associated with protection against recurrent ocular herpes. Based on these findings, a novel "prime/pull" therapeutic ocular herpes vaccine strategy is proposed and discussed.
[Mh] MeSH terms primary: CD8-Positive T-Lymphocytes/immunology
Chemokine CXCL10/metabolism
Herpes Simplex/immunology
Immunologic Memory
Receptors, CXCR3/metabolism
Simplexvirus/immunology
[Mh] MeSH terms secundary: Animals
Chemokine CXCL10/deficiency
Cornea/immunology
Cornea/virology
Disease Models, Animal
Herpes Simplex/prevention & control
Mice, Inbred C57BL
Mice, Knockout
Receptors, CXCR3/deficiency
Recurrence
Trigeminal Ganglion/immunology
Trigeminal Ganglion/virology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Chemokine CXCL10); 0 (Cxcl10 protein, mouse); 0 (Cxcr3 protein, mouse); 0 (Receptors, CXCR3)
[Em] Entry month:1707
[Cu] Class update date: 171226
[Lr] Last revision date:171226
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE

  10 / 17568 MEDLINE  
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[PMID]: 29206634
[Au] Autor:Di Bona D; Fiorino I; Taurino M; Frisenda F; Minenna E; Pasculli C; Kourtis G; Rucco AS; Nico A; Albanesi M; Giliberti L; D'Elia L; Caiaffa MF; Macchia L
[Ad] Address:School and Chair of Allergology and Clinical Immunology, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Italy. Electronic address: danilo.dibona@uniba.it.
[Ti] Title:Long-term "real-life" safety of omalizumab in patients with severe uncontrolled asthma: A nine-year study.
[So] Source:Respir Med;130:55-60, 2017 Sep.
[Is] ISSN:1532-3064
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Randomized Controlled Trials showed that omalizumab exhibited a good safety and tolerability profile in patients with moderate-to-severe asthma. However, safety data of long-term treatment with omalizumab are scarce. Our aim was to assess the safety of omalizumab in patients under long-term treatment in a real-life setting. METHODS: Difficult-to-control asthmatic patients treated with omalizumab up to 9 years were retrospectively evaluated. Mild to severe adverse events any and reasons for discontinuation were recorded. RESULTS: Ninety-one patients (26.4% males, mean age 49.9 ± 14.9 years) were included: mean treatment length, 3.8 ± 2.6 years; mean individual monthly dose, 514.5 ± 345.7 mg (range, 150-1200 mg). A total of 10,472 single injections were given cumulatively to the 91 patients (115 single injections per patients, on average, over a treatment period up to 9 years). Fifty-nine patients (64.8%) were treated for a period of time from 3 to 9 years, 14 of whom from 6 to 9 years. A high proportion of patients who discontinued treatment dropped out within the first year (18, 39.1%), mainly for reasons unrelated to treatment. Six patients (6.6%) discontinued omalizumab for treatment-related adverse events: arthralgia/myalgia (3 patients); urticaria, angioedema (1 patients); metrorrhagia (1 patient); relapsing herpes labialis (1 patient). Four other patients complained of mild adverse events (rhinitis/conjunctivitis, injection site reaction, fatigue, thrombosis) but continued the treatment. Anaphylaxis was not reported. CONCLUSIONS: Long-term treatment with omalizumab appears remarkably safe and well tolerated in real-life setting. Prolonged omalizumab treatment for many consecutive years did not increase the risk of side effects, particularly anaphylaxis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171205
[Lr] Last revision date:171205
[St] Status:In-Process


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