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[PMID]: 27135374
[Au] Autor:Wang JJ; Dahlgren RA; Ersan MS; Karanfil T; Chow AT
[Ad] Address:Baruch Institute of Coastal Ecology & Forest Science, Clemson University, Georgetown, SC, 29442, USA....
[Ti] Title:Temporal variations of disinfection byproduct precursors in wildfire detritus.
[So] Source:Water Res;99:66-73, 2016 Aug 1.
[Is] ISSN:1879-2448
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The Rim Fire ignited on August 17, 2013 and became the third largest wildfire in California history. The fire consumed 104,131 ha of forested watersheds that were the drinking water source for 2.6 million residents in the San Francisco Bay area. To understand temporal variations in dissolved organic matter (DOM) after the wildfire and its potential impacts on disinfection byproduct (DBP) formation in source water supply, we collected the 0-5 cm ash/soil layer with surface deposits of white ash (high burn severity) and black ash (moderate burn severity) within the Rim Fire perimeter in Oct 2013 (pre-rainfall) for five sequential extractions, and in Dec 2013 (∼87 mm cumulative precipitation) and Aug 2014 (∼617 mm cumulative precipitation) for a single water extraction. Water-extractable DOM was characterized by absorption and fluorescence spectroscopy and DBP formation tests. Both increasing cumulative precipitation in the field or number of extractions in the lab resulted in a significant decrease in specific conductivity, dissolved organic carbon, and DBP formation potential, but an increase in DOM aromaticity (reflected by specific UV absorbance). However, the lab sequential leaching failed to capture the increase of the NOx(-)-N/NH4(+)-N ratio and the decrease in pH and dissolved organic carbon/nitrogen ratio of ash/soil extracts from Oct 2013 to Aug 2014. Increasing cumulative precipitation, inferring an increase in leaching after fire, led to an increase in DOM reactivity to form trihalomethanes, haloacetic acids, and chloral hydrate, but not for haloketones, haloacetonitrile, or N-nitrosodimethylamine, which were more related to the original burn severity. This study highlights that fire-affected DBP precursors for different DBP species have distinct temporal variation possibly due to their various sensitivity to biogeochemical alterations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 806861 MEDLINE  
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[PMID]: 26921106
[Au] Autor:Gentili ME
[Ad] Address:Centre hospitalier privé de Saint-Grégoire, 35760 Saint-Grégoire, France. Electronic address: Marc.e.gentili@orange.fr.
[Ti] Title:Norman Béthune (1890-1939) médecin engagé et icône de la transfusion sanguine. [Norman Bethune (1890-1939), an involved doctor, icon of the blood transfusion history].
[So] Source:Transfus Clin Biol;23(2):106-9, 2016 May.
[Is] ISSN:1953-8022
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:Norman Bethune was born in 1890, in Gravenhurst (Ontario, Canada). Thereafter a strong surgical training, he implied in thoracic surgery and fight against tuberculosis. His political opinions led him to join the Republicans in the Spanish Civil War. He played an important part in the development of blood transfusion on the battlefield. Then he joined China with communist troops and therein developed surgical units and accelerated training for health personal. He died of septicemia in 1939.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 27181383
[Au] Autor:Valsangkar NP; Kays JK; Feliciano DV; Martin PJ; Parett JS; Joshi MM; Zimmers TA; Koniaris LG
[Ad] Address:Department of Surgery, Indiana University School of Medicine, Indianapolis, IN....
[Ti] Title:The impact of members of the Society of University Surgeons on the scholarship of American surgery.
[So] Source:Surgery;160(1):47-53, 2016 Jul.
[Is] ISSN:1532-7361
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: A core objective of the Society of University Surgeons (SUS) is research focused: to "advance the art and science of surgery through original investigation." This study sought to determine the current impact of the SUS on academic surgical productivity. METHODS: Individual faculty data for numbers of publications, citations, and National Institute of Health (NIH) funding history were collected for 4,015 surgical faculty at the top 55 NIH-funded departments of surgery using SCOPUS and the NIH Research Portfolio Online Reporting Tools. SUS membership was determined from membership registry data. RESULTS: Overall, 502 surgical faculty (12.5%) were SUS members with 92.7% holding positions of associate or full professor (versus 59% of nonmembers). Median publications (P) and citations (C) among SUS members were P: 112, C: 2,460 versus P: 29, C: 467 for nonmembers (P < .001). Academic productivity was considerably higher by rank for SUS members than for nonmembers: associate professors (P: 61 vs 36, C: 1,199 vs 591, P < .001) and full professors (P: 141 vs 81, C: 3,537 vs 1,856, P < .001). Among full professors, SUS members had much higher rates of NIH funding than did nonmembers (52.6% vs 26%, P < .05) and specifically for R01, P01, and U01 awards (37% vs 17.7%, P < .01). SUS members were 2 times more likely to serve in divisional leadership or chair positions (23.5% vs 10.2%, P < .05). CONCLUSION: SUS society members are a highly productive academic group. These data support the premise that the SUS is meeting its research mission and identify its members as very academically productive contributors to research and scholarship in American surgery and medicine.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

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[PMID]: 27085685
[Au] Autor:Henriksen NA; Mortensen JH; Lorentzen L; Ågren MS; Bay-Jensen AC; Jorgensen LN; Karsdal MA
[Ad] Address:Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address: nadiahenriksen@gmail.com....
[Ti] Title:Abdominal wall hernias-A local manifestation of systemically impaired quality of the extracellular matrix.
[So] Source:Surgery;160(1):220-7, 2016 Jul.
[Is] ISSN:1532-7361
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Throughout life, inguinal hernia develops in approximately every fourth man, some of whom develop multiple hernias. If patients at risk of developing multiple hernias could be identified by a serologic biomarker, treatment might be able to be tailored and improved. Evidence suggests that abdominal wall hernia formation is associated with altered collagen metabolism. The aim of this study was to evaluate biomarkers for type IV and V collagen turnover in patients with multiple hernias and control subjects without hernia. METHODS: Venous blood was collected from 88 men (mean age, 62 years) with a history of more than 3 hernia repairs and 86, age-matched men without hernias. Biomarkers for synthesis of collagen type IV (P4NP) and type V (P5CP) as well as breakdown (C4M and C5M) were measured in serum by validated, solid-phase, competitive assays. Collagen turnover was indicated by the ratio between the biomarker for synthesis and breakdown. RESULTS: Type IV collagen turnover was 1.4-fold increased in patients with multiple hernias compared to control subjects (P < .001), whereas type V collagen turnover was 1.7-fold decreased (P < .001). Diagnostic power of P5CP was 0.83 (95%C.I.:0.77-0.89), P < .001. CONCLUSION: Patients with multiple hernias exhibit increased turnover of type IV collagen and a decreased turnover of type V collagen, demonstrating systemically altered collagen turnover. Biomarkers for type V collagen turnover may be used to identify patients at risk for or with multiple hernias.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  5 / 806861 MEDLINE  
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[PMID]: 27085683
[Au] Autor:Sharma G; Kulkarni R; Shah SK; King WW; Longchamp A; Tao M; Ding K; Ozaki CK
[Ad] Address:Department of Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, MA....
[Ti] Title:Local perivascular adiponectin associates with lower extremity vascular operative wound complications.
[So] Source:Surgery;160(1):204-10, 2016 Jul.
[Is] ISSN:1532-7361
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Wound complication rates after lower extremity vascular operative procedures stand as high as 40% and represent a major cause of morbidity, mortality, and cost. In view of increasing recognition of adipose tissue involvement in homeostasis and the response to injury, we hypothesized that adipose phenotype is linked to operative wound outcomes. METHODS: Clinical history, peripheral blood, and subcutaneous and perivascular adipose tissue were prospectively collected at the time of operation in patients undergoing lower extremity revascularization and lower extremity amputations. Nine biologic mediators (adiponectin; interleukin [IL]-1ß, IL-6, and IL-8; leptin; monocyte chemoattractant protein-1; plasminogen activator inhibitor-1; resistin; and tumor necrosis factor) were assayed in the adipose tissues and plasma. The 30-day wound complications were captured in real time. Logarithmic transformation of mediator levels was performed based on positively skewed, non-Gaussian distribution, and data were compared using the Student t test. Bonferroni correction was used for multiple comparisons. RESULTS: Sixty-six patients undergoing lower extremity revascularization or lower extremity amputations for severe peripheral arterial disease were enrolled. The 30-day follow-up was 92.4%. In total, 19 (29%) patients developed wound complications. Patients who developed wound complications had elevated perivascular adiponectin levels (mean ± standard error, 2,372.45 ± 648.64 ng/mL vs 832.53 ± 180.54 ng/mL, P = .004). Perivascular IL-1ß levels were lower among patients with wound dehiscence (0.41 ± 0.004 pg/mL vs 0.73 ± 0.09 pg/mL, P = .001). CONCLUSION: Local adipose tissue mediator levels at the time of operation demonstrate a previously undescribed compartment-specific relationship to wound outcomes in patients undergoing lower extremity vascular operative procedures. These associations provide fertile directives for defining the mechanisms underlying the pathogenesis of wound complications and their prevention.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  6 / 806861 MEDLINE  
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[PMID]: 26908926
[Au] Autor:Mukherjee P; Sabharwal A; Kotov R; Szekely A; Parsey R; Barch DM; Mohanty A
[Ad] Address:University of California Davis MIND Institute, UC Davis Medical Center, Sacramento, CA;...
[Ti] Title:Disconnection Between Amygdala and Medial Prefrontal Cortex in Psychotic Disorders.
[So] Source:Schizophr Bull;42(4):1056-67, 2016 Jul.
[Is] ISSN:1745-1701
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Distracting emotional information impairs attention more in schizophrenia (SCZ) than in never-psychotic individuals. However, it is unclear whether this impairment and its neural circuitry is indicative generally of psychosis, or specifically of SCZ, and whether it is even more specific to certain SCZ symptoms (eg, deficit syndrome). It is also unclear if this abnormality contributes to impaired behavioral performance and real-world functioning. Functional imaging data were recorded while individuals with SCZ, bipolar disorder with psychosis (BDP) and no history of psychotic disorders (CON) attended to identity of faces while ignoring their emotional expressions. We examined group differences in functional connectivity between amygdala, involved in emotional evaluation, and sub-regions of medial prefrontal cortex (MPFC), involved in emotion regulation and cognitive control. Additionally, we examined correlation of this connectivity with deficit syndrome and real-world functioning. Behaviorally, SCZ showed the worst accuracy when matching the identity of emotional vs neutral faces. Neurally, SCZ showed lower amygdala-MPFC connectivity than BDP and CON. BPD did not differ from CON, neurally or behaviorally. In patients, reduced amygdala-MPFC connectivity during emotional distractors was related to worse emotional vs neutral accuracy, greater deficit syndrome severity, and unemployment. Thus, reduced amygdala-MPFC functional connectivity during emotional distractors reflects a deficit that is specific to SCZ. This reduction in connectivity is associated with worse clinical and real-world functioning. Overall, these findings provide support for the specificity and clinical utility of amygdala-MPFC functional connectivity as a potential neural marker of SCZ.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/schbul/sbw012

  7 / 806861 MEDLINE  
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[PMID]: 26346417
[Au] Autor:M'Saad S; Kammoun K; Yangui I; Fourati H; Feki W; Marouen F; Daoud E; Kammoun S
[Ad] Address:Service de pneumo-allergologie, CHU Hédi-Chaker, faculté de médecine de Sfax, route al Ain, Km 0,5, 3029 Sfax, Tunisie. Electronic address: msaadsameh@yahoo.fr....
[Ti] Title:Micropolyangéite, syndrome d'emphysème des sommets et fibrose pulmonaire des bases. [Combined pulmonary fibrosis and emphysema associated with microscopic polyangiitis].
[So] Source:Rev Mal Respir;33(5):391-6, 2016 May.
[Is] ISSN:1776-2588
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) is a rare entity of unknown etiology. It usually occurs in the context of smoking and, less commonly, connective tissue disease. However, it has been rarely previously described in the context of vasculitis. OBSERVATION: We report a case of CPFE occurring in a 44-year-old man, who was a light smoker without any previous medical history. He presented with fever, chronic cough and breathlessness that progressively evolved to acute respiratory failure. At the initial evaluation, CT scan showed emphysema and patchy bilateral areas of ground-glass opacity. Three years later, the patient simultaneously developed a honeycomb fibrosis and a microscopic polyangiitis with renal involvement justifying the introduction of an immunosuppressive treatment in combination with high dose of systemic corticosteroids. After a stabilization period of 6years, the patient gradually developed chronic respiratory failure with moderate pulmonary hypertension requiring long-term oxygen therapy and nocturnal non-invasive ventilation. CONCLUSION: The association of microscopic polyangiitis to CFPE suggests that autoimmune diseases may have a common pathogenic role in the development of emphysematous and fibrotic lesions in CPFE.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 27234913
[Au] Autor:Terrier LM; François P
[Ad] Address:Service de neurochirurgie, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex 9, France. Electronic address: lmterrier14@gmail.com.
[Ti] Title:Méningiomes multiples. [Multiple meningiomas].
[So] Source:Neurochirurgie;62(3):128-35, 2016 Jun.
[Is] ISSN:1773-0619
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:Multiple meningiomas (MMs) or meningiomatosis are defined by the presence of at least 2 lesions that appear simultaneously or not, at different intracranial locations, without the association of neurofibromatosis. They present 1-9 % of meningiomas with a female predominance. The occurrence of multiple meningiomas is not clear. There are 2 main hypotheses for their development, one that supports the independent evolution of these tumors and the other, completely opposite, that suggests the propagation of tumor cells of a unique clone transformation, through cerebrospinal fluid. NF2 gene mutation is an important intrinsic risk factor in the etiology of multiple meningiomas and some exogenous risk factors have been suspected but only ionizing radiation exposure has been proven. These tumors can grow anywhere in the skull but they are more frequently observed in supratentorial locations. Their histologic types are similar to unique meningiomas of psammomatous, fibroblastic, meningothelial or transitional type and in most cases are benign tumors. The prognosis of these tumors is eventually good and does not differ from the unique tumors except for the cases of radiation-induced multiple meningiomas, in the context of NF2 or when diagnosed in children where the outcome is less favorable. Each meningioma lesion should be dealt with individually and their multiple character should not justify their resection at all costs.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 806861 MEDLINE  
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[PMID]: 27234912
[Au] Autor:Brunon J
[Ad] Address:Service de neurochirurgie, CHU de Saint-Étienne, 42055 Saint-Étienne cedex, France. Electronic address: jbrunon@club-internet.fr.
[Ti] Title:Aux origines de la neurochirurgie française. [The origins of the French neurosurgery].
[So] Source:Neurochirurgie;62(3):119-27, 2016 Jun.
[Is] ISSN:1773-0619
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:Modern French neurosurgery starts at the beginning of the XXth century under the motivation of Joseph Babinski. He submitted his patients to Thierry de Martel who had learned this new specialized area of medicine with H. Cushing in the États-Unis and V. Horsey in Great Britain. His first successfully treated case of an intracranial tumor was published in 1909. But the true founding father was Clovis Vincent, initially a neurologist and collaborator of de Martel, who became the first chairman in 1933 of the neurosurgical department at the Pitié hospital of Paris and the first professor of neurosurgery in 1938. After the Second World War, many departments were created outside of Paris. Neurosurgery was definitively recognized as a specialized area in medicine in 1948. Currently, more than 400 neurosurgeons work in France. Because I had the very great privilege to be present at the birth of this society in 1970 and to still be in contact with some of the second and third generation of French neurosurgeons who led it to its high international recognition, the Chairman of the French Neurosurgical Society asked me to write this short historical vignette.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 806861 MEDLINE  
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[PMID]: 26746043
[Au] Autor:Ng JP; Cawley DT; Beecher SM; Lee MJ; Bergin D; Shannon FJ
[Ad] Address:Dept of Trauma & Orthopaedic Surgery, Galway University Hospitals, Ireland. Electronic address: ngjp2606@gmail.com....
[Ti] Title:Focal intratendinous radiolucency: A new radiographic method for diagnosing patellar tendon ruptures.
[So] Source:Knee;23(3):482-6, 2016 Jun.
[Is] ISSN:1873-5800
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Diagnosis of patellar tendon rupture is usually based on clinical history and examination. In equivocal cases, imaging may be required. Lateral radiograph is a simple and cost-effective method for prompt diagnosis. However, no specific radiological sign has been described. Rather than utilising patella alta as an indirect measure of patellar tendon rupture, we hypothesise that a focal intratendinous radiolucency is another reliable and accurate radiological sign for diagnosis. Sensitivity and specificity analysis was undertaken to evaluate the diagnostic value of this radiographic sign. METHODS: Lateral radiographs of mid-substance patellar tendon ruptures from 19 patients were analysed. These were then randomised with another 19 normal knee radiographs from age-matched patients to create a pool of 38 radiographs for interpretation. Six independent interpreters who were blinded to the diagnosis were requested to indicate whether rupture was present or absent based on the visualisation of a focal intratendinous radiolucency in the patellar tendon. The Insall-Salvati (IS), Caton-Deschamps (CD) and Blackburne-Peel (BP) ratios were measured in the same radiographs. Sensitivity and specificity for each of the radiographic measurements were calculated. Inter- and intraobserver correlations were reported in kappa statistics. RESULTS: The average sensitivity and specificity for focal radiolucency in the patellar tendon substance were 82.5% and 95.2%, respectively. Sensitivity and specificity for the IS ratio were 84.2% and 78.9%, for CD was 68.4% and 84.2% and for BP was 68.4% and 89.4% respectively. CONCLUSION: The presence of a focal intratendinous radiolucency in the patellar tendon is both accurate and reliable in diagnosing patellar tendon ruptures.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review


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