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[PMID]: 25042917
[Au] Autor:Zhang T; Tian R; Zhang S; Wu W; Liu Z; Fang Q; Xie H; Shen Z; Zeng Y
[Ad] Address:Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China....
[Ti] Title:[Clinical features of patients with premature acute coronary syndrome].
[So] Source:Zhonghua Xin Xue Guan Bing Za Zhi;42(5):392-5, 2014 May.
[Is] ISSN:0253-3758
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To analyze the clinical features of patients with premature acute coronary syndrome(ACS). METHODS: Three hundreds and forty seven patients with ACS who underwent coronary angiography from January 2011 to June 2013 in our department were included in this study. Eligible patients were divided into premature group (pre-group, male < 55 years old, female < 65 years old, n = 140) and non-premature group(N-pre group, male ≥ 55 years old, female ≥ 65 years old, n = 207). The cardiovascular risk factors, coronary angiography (CAG) features, complications and in-hospital mortality were analyzed. RESULTS: Compared to N-pre group, the pre-group had a significantly higher rate of smoking [56.4% (79/140) vs. 44.4% (92/207), P < 0.05], dyslipidemia [61.4% (86/140) vs. 50.2% (104/207), P < 0.05] and positive family history of coronary artery disease [39.3% (55/140) vs. 24.6% (51/207), P < 0.01]. However, other traditional cardiovascular risk factors were less (3.03 ± 1.28 vs. 3.91 ± 1.30, P < 0.01). CAG identified higher incidence of one-vessel and double-vessel diseases (63.6%, 89/140) in pre-group, but the incidence of multi-vessel diseases (57.0%, 118/207) was more frequent in N-pre group . Moreover, the pre-group had a higher rate of coronary artery occlusion [45.7% (64/140) vs. 34.8% (72/207), P < 0.05]. Compared with N-pre group, the pre-group had a lower Gensini Score of CAG (46.2 ± 33.2 vs. 60.4 ± 37.5, P < 0.01) and a lower rate of heart failure[4.3% (6/140) vs. 11.1% (23/207), P < 0.05] during hospitalization. In-hospital mortality rate was similar between the two groups [0 vs. 1.9% (4/207), P > 0.05]. CONCLUSION: Smoking, dyslipidemia and family history of coronary artery disease are major risk factors for patients with premature ACS, these patients are more likely to have milder coronary artery stenosis and a lower incidence of heart failure compared to N-pre group.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 729394 MEDLINE  
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[PMID]: 24712334
[Au] Autor:Schönbacher M; Heinzl MW; Dauber EM; Mayr WR; Panzer S; Körmöczi GF
[Ad] Address:Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
[Ti] Title:Granulocyte-reactive antibodies are associated with red blood cell alloimmunization.
[So] Source:Vox Sang;107(2):200-3, 2014 Aug.
[Is] ISSN:1423-0410
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Granulocyte-reactive antibodies may cause transfusion-related acute lung injury (TRALI) and immune neutropenias. Risk factors for their acquisition other than previous alloexposition are largely unknown. In addition to the known association between human leucocyte antigen alloantibodies and red blood cell alloimmunization in selected cohorts of transfused patients, this study investigated a possible extension of this association to granulocyte-reactive antibodies in women with a history of pregnancy. The overall prevalence of granulocyte-reactive antibodies in 333 samples from women with a history of pregnancy (143 samples containing red cell alloantibodies) was 23·1%. The prevalence in the red cell-alloimmunized group (32·9%) was significantly higher than in controls (15·8%, P < 0·001). This could suggest that some individuals may be strong immunological responders, forming alloantibodies more readily than others.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/vox.12152

  3 / 729394 MEDLINE  
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[PMID]: 24552135
[Au] Autor:Lindsted G; Larsen R; Krøigaard M; Garvey LH; Poulsen LK; Mosbech H; Sørensen B; Norgaard A
[Ad] Address:Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Danish Anaesthesia Allergy Centre, Allergy Clinic, Copenhagen University Hospital, Gentofte, Denmark.
[Ti] Title:Transfusion-associated anaphylaxis during anaesthesia and surgery - a retrospective study.
[So] Source:Vox Sang;107(2):158-65, 2014 Aug.
[Is] ISSN:1423-0410
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND AND OBJECTIVES: Transfusion-associated anaphylaxis (TAA) is a severe adverse reaction reported to occur in 1:9000-90 000 transfusions. According to the Danish Registration of Transfusion Risks (DART), the frequency is 1:300 000 transfusions, which suggests insufficient reporting of TAA in Denmark. Our aims were to identify possible cases of TAA, to characterize their symptoms and tryptase levels and to investigate the reporting of TAA to the haemovigilance systems. MATERIAL AND METHODS: We reviewed 245 patients with suspected allergic reactions during anaesthesia and surgery, investigated at the Danish Anaesthesia Allergy Centre (DAAC). Based on the outcome of this investigation, the patients were classified as DAAC positive (confirmed hypersensitivity to identified agent, n = 112), or DAAC negative (no confirmed hypersensitivity, n = 133). Data on case history, details of blood transfusion and results of laboratory and clinical investigations were collected. TAA cases were identified according to the recommendations of the International Society of Blood Transfusion (ISBT). RESULTS: Ten possible TAA cases (30% of all transfused patients) were identified, all DAAC negative. The frequency of elevated serum tryptase, hypotension and male sex was significantly higher among these cases compared with the remaining DAAC negative (P < 0·05), but not different from the DAAC-positive patients. One case had been reported to the Blood Bank haemovigilance system and none to DART. CONCLUSION: We identified unreported cases of possible TAA, which resembled the DAAC-positive patients with respect to elevated tryptase and symptoms. By applying the ISBT criteria of adverse transfusion reactions, we conclude that TAA during anaesthesia and surgery is likely to be underreported in Denmark.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/vox.12133

  4 / 729394 MEDLINE  
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[PMID]: 24712858
[Au] Autor:Krauss MW; Benato L; Wack A; McDonnell JJ; Schoemaker NJ; Westerhof I; Bronson E; Gielen I; Van Caelenberg A; Hellebuyck T; Meij BP; De Decker S
[Ad] Address:Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
[Ti] Title:Intervertebral Disk Disease in 3 Striped Skunks (Mephitis mephitis).
[So] Source:Vet Surg;43(5):589-92, 2014 Jul.
[Is] ISSN:1532-950X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To describe diagnostic findings, surgical technique, and outcome in 3 striped skunks (Mephitis mephitis) with a history of paraparesis. STUDY DESIGN: Case series. ANIMALS: Skunks (n = 3) with paraparesis. METHODS: Neurologic examination revealed upper motor neuron disease (T2-L2) in 2 skunks and lower motor neuron disease (L3-S3) in 1 skunk. Diagnostic imaging included radiography, myelography, CT, and MRI and confirmed intervertebral disk herniation (IVDH) in each skunk. Because initial treatment with pain medication and cage rest did not result in lasting improvement, spinal surgery was performed. RESULTS: Hemilaminectomy (2 skunks) and dorsal laminectomy (1 skunk) was performed with removal of extruded disk material. The skunks improved after surgery but all had minor residual neurologic deficits when examined at various times postoperatively. CONCLUSION: Thoracolumbar intervertebral disk herniation occurs in skunks, and must be included in the differential diagnosis of paraparesis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/j.1532-950X.2014.12187.x

  5 / 729394 MEDLINE  
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[PMID]: 24372970
[Au] Autor:Woodland M; Pack L; Rist P; Crane B
[Ad] Address:Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada.
[Ti] Title:Comparison of digital radiography, ultrasonography, and positive contrast vaginourethrography for determining reproductive status of female cats.
[So] Source:Vet Radiol Ultrasound;55(4):368-73, 2014 Jul.
[Is] ISSN:1740-8261
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:It is not always possible to identify female cats that have undergone previous ovariohysterectomy based on physical examination alone. An easy, cost-effective method for screening female cats for reproductive status would be helpful for avoiding unnecessary exploratory laparotomies. The purpose of this prospective study was to compare diagnostic sensitivities of digital radiography, ultrasonography, and positive contrast vaginourethrography for determining reproductive status in female cats. Sixty-seven recently euthanized female cats of unknown medical history and reproductive status were randomly selected and included in the study. Digital abdominal radiography, digital abdominal radiography with compression, abdominal ultrasonography, and positive contrast vaginourethrography were performed in sequence by a board-certified veterinary radiologist and a second-year radiology resident. Immediately following diagnostic imaging procedures, necropsy was performed. Ultrasonography of the uterus had the highest sensitivity (86%) for determining reproductive status of all the imaging modalities tested. The specificity was 88%, and the positive predictive value and negative predictive value were 96% and 68%, respectively. The calculated sensitivities and specificities of other modalities were as follows: digital radiographs (28%, 100%), digital compression radiographs (58%, 100%), and vaginourethrography (32%, 100%). Based on McNemar's test statistic, there was a significant difference in the sensitivity of ultrasound compared to digital radiographs (P ≤ 0.05), compression radiographs (P ≤ 0.05), and vaginourethrogram (P ≤ 0.05). Findings from the current study indicated that ultrasonography is a sensitive diagnostic test for determining reproductive status in female cats. Although more readily available in private practice and shelters, digital radiography and vaginourethrography are not reliable predictors of reproductive status.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/vru.12134

  6 / 729394 MEDLINE  
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[PMID]: 23815130
[Au] Autor:Theobald A; Dennis R; Beltran E
[Ad] Address:Animal Health Trust, Centre for Small Animal Studies, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK.
[Ti] Title:Imaging diagnosis - spontaneous subperiosteal vertebral hemorrhage in a greyhound.
[So] Source:Vet Radiol Ultrasound;55(4):420-3, 2014 Jul.
[Is] ISSN:1740-8261
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A 4-year-old, spayed female greyhound dog was presented with an acute onset of paraplegia. There was no known history of trauma or coagulopathy. Spinal cord compression was identified on MRI. Intra-operative evaluation revealed the presence of a large subperiosteal hematoma and a smaller epidural hematoma. To the authors' knowledge, this is the first report of a spinal subperiosteal hematoma diagnosed antemortem through MRI, with surgical exploration and successful treatment in a dog.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/vru.12076

  7 / 729394 MEDLINE  
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[PMID]: 24999181
[Au] Autor:Ley B; Daubs B; Bader J; Silverman E
[Ad] Address:Benjamin Ley, DVM, El Paso Veterinary Specialty Center, 1220 Airway Blvd, El Paso, TX 70025, United States, Phone: +1 727 504 0724, Fax: +1915 532 3593, E-mail: gmacanthor@gmail.com.
[Ti] Title:Assessment of the medial collateral ligament as an intra-operative anatomical landmark for tibial plateau levelling osteotomy.
[So] Source:Vet Comp Orthop Traumatol;27(4):285-7, 2014 Jul 21.
[Is] ISSN:0932-0814
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Objectives: To determine whether the medial collateral ligament can be a reliable intra-operative anatomical landmark for rotation of the tibial plateau in the tibial plateau levelling osteotomy (TPLO) procedure, thus providing a tibial plateau rotation equal to that obtained using standard preoperative measurements. Methods: Tibial plateau levelling osteotomy procedures were performed on pelvic limbs (n = 42) from canine cadavers with or without a history of cranial cruciate ligament deficiency. The rotation of the proximal fragment was performed such that the orientation of the fibres of the medial collateral ligament were aligned parallel to the caudal tibial cortex at the location of the osteotomy. Statistical analysis was performed to evaluate the difference between calculated rotation to achieve a postoperative tibial plateau angle of five degrees and the actual rotation achieved by aligning the medial collateral ligament and caudal tibial cortex. Results: The rotation performed by alignment of the medial collateral ligament fibres with the caudal tibial cortex resulted in a significantly greater rotation than the calculated movement required to achieve a postoperative angle of five degrees. The mean over-rotation was 2.1 ± 1.73 mm. Clinical significance: Use of the medial collateral ligament alignment with the caudal tibial cortex will reliably result in over-rotation of the tibial plateau and should not be used as an intra-operative guideline for tibial plateau rotation during TPLO procedures.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3415/VCOT-14-02-0033

  8 / 729394 MEDLINE  
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[PMID]: 24992658
[Au] Autor:Aikawa T; Sadahiro S; Nishimura M; Miyazaki Y; Shibata M
[Ad] Address:Takeshi Aikawa, BVSc, Diplomate JCVS, Aikawa Veterinary Medical Center, 4-3-1 Nishi Otiai, Shinjuku-ku, Tokyo 161-0031, Japan, Phone: + 81 3 5988 7887, Fax: + 81 3 5988 7887, E-mail: taikawa@wb3.so-net.ne.jp.
[Ti] Title:Ganglion cyst arising from the composite occipito-atlanto-axial joint cavity in a cat.
[So] Source:Vet Comp Orthop Traumatol;27(4):319-23, 2014 Jul 21.
[Is] ISSN:0932-0814
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:A four-year-old, female spayed Domestic Longhaired cat was referred for evaluation with a two month history of initial inability to jump progressing to ambulatory tetraparesis. Magnetic resonance imaging studies demonstrated a cystic lesion arising from the composite occipito-atlanto-axial joint cavity and extending to the region of the occipital bone and the axis. The lesion surrounded the spinal canal, causing moderate dorsal spinal cord compression at the atlanto-occipital joint. A dynamic myelographic study demonstrated attenuation of the dorsal contrast column at the atlanto-occipital joint when the cervical spine was positioned in extension. Partial excision of the cyst capsule by a ventral approach resulted in long-term (64 months) resolution of clinical signs. Histological evaluation was consistent with a ganglion cyst. An intra-spinal ganglion cyst arising from the composite occipito-atlanto-axial joint cavity may be considered as an uncommon differential diagnosis for cats with cervical myelopathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3415/VCOT-13-10-0119

  9 / 729394 MEDLINE  
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[PMID]: 24916763
[Au] Autor:Erkurt B; Kiremit MC; Altay B; Guzelburc V; Soytas M; Erdogan F; Barisik CC; Albayrak S
[Ad] Address:Department of Urology, Medical Faculty of Medipol University, TEM Avrupa Otoyolu Goztepe Cikisi No: 1 Bagcilar, 34214, Istanbul, Turkey, bulent.erkurt@medipol.com.tr.
[Ti] Title:Is retrograde flexible nephrolithotripsy feasible for calyceal diverticular stone?
[So] Source:Urolithiasis;42(4):347-51, 2014 Aug.
[Is] ISSN:2194-7236
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The aim of this study is to manage the calyceal diverticular (CD) stone, several treatment options were applied but it is still a challenging condition of endourology. In this retrospective study, we aim to report the results of our patients with CD stones treated with retrograde flexible nephrolithotripsy (RFNL). A total of 47 patients (55 procedures) who underwent RFNL by a single surgeon for CD stones from January 2004 to March 2013 were evaluated retrospectively. The demographic properties and initial complaints of those patients have been recorded along with their comorbidities and previous history of stone management. Moreover, the size and number of the stones, the duration of the surgery, fluoroscopy time, stone-free rate (SFR) and postoperative complications of the patients have been evaluated. The mean age was 41.8 years (range 16-71). Of the study population, 31 (65.9 %) were male. Mean stone size was 21.1 (7-52) mm whereas in 3 (6.4 %) of the cases the stones could not be reached. Mean duration of the surgery was 92.8 (57-163) min whereas mean fluoroscopy time was 35.9 (14-103) s. After 3 months of follow-up period, the SFR was 85.1 %. No major complications occurred. RFNL with holmium laser and nitinol basket catheter application is a feasible and successful procedure in the management of CD stones. With its high success rates, low incidence of complications and minimal morbidity when compared with other treatment options, RFNL has the potential of becoming the preferred treatment option in the minimally invasive management of patients with CD stones.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00240-014-0672-1

  10 / 729394 MEDLINE  
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[PMID]: 24894816
[Au] Autor:Walker V; Cook P; Griffin DG
[Ad] Address:Department of Clinical Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton, UK, valerie.walker@uhs.nhs.uk.
[Ti] Title:Characterisation of risk factors for stones in hyperuricosuric men attending a stone clinic.
[So] Source:Urolithiasis;42(4):291-300, 2014 Aug.
[Is] ISSN:2194-7236
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Hyperuricosuria is common among stone formers, but its significance is uncertain. To progress our understanding and target treatment, we need to identify and characterise patients with uniform underlying pathology. We aimed to identify hyperuricosuric patients with a primary defect in renal urate reabsorption (renal hyperuricosuria) and to look for associated risk factors for stones. We undertook a retrospective cross-sectional database study of 666 male stone formers attending the Southampton stone clinic. We estimated filtered urate from plasma urate and 24-h creatinine clearance, and the net percentage reabsorbed. 153 men had hyperuricosuria (urine urate >4.80 mmol/24 h); 513 had normouricosuria. Hyperuricosuric men filtered more urate (median 68.1 and 52.5 mmol/24 h) but the ranges overlapped. Thirty hyperuricosuric men with filtered urate below the median for normouricosuria were selected as the renal hyperuricosuria group. Their normal plasma urate and high urate clearance substantiated this classification. In comparison with 60 normouricosuric stone formers matched for filtration, they had a higher incidence of hypercalciuria (67 versus 40 %), but similar, high, frequencies of hyperoxaluria (25 and 11 %) and phosphaturia (40 and 27 %).There were no differences in age at first stone, incidence of stone recurrence or positive family history (20 and 25 %). The findings demonstrate multiple risk factors for stones in this subgroup. In comparison, the 30 hyperuricosuric men with the highest filtration had a higher incidence of hyperoxaluria (58 %) but fewer (7 %) had a positive family history. Creatinine clearance was raised in 73 %. An excessive protein intake might be a major correctable factor underlying these abnormalities.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00240-014-0667-y


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