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[PMID]: 25699231
[Au] Autor:Lubrano V; Balzan S
[Ad] Address:Valter Lubrano, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy.
[Ti] Title:Consolidated and emerging inflammatory markers in coronary artery disease.
[So] Source:World J Exp Med;5(1):21-32, 2015 Feb 20.
[Is] ISSN:2220-315X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Coronary artery disease is an event of atherosclerosis characterized by a chronic vascular inflammation. Risk factors like obesity, diabetes mellitus, hypertension, smoking, hypercholesterolemia and positive family history sometimes are not sufficiently adequate to the enhancement of cardiovascular risk assessment. In the past years numerous biomarkers, like C reactive protein, cytokines and adhesion molecules, have been observed to be related to adverse cardiovascular prognosis. Recently, several studies found an association among inflammatory biomarkers and cardiovascular diseases suggesting their utility to identify the risk of an acute ischemic event and the detection of vulnerable plaques. The emerging inflammatory markers are well divided for diagnosis and prognosis and plaque instability of coronary artery disease. Some of them, the lectin-like oxidized low density lipoprotein receptor-1 can be important both in diagnosis and in the evaluation of plaque instability, other are inserted in the above reported classification. The emerging inflammatory markers in acute-phase include amyloid A, fibrinogen and pentraxin 3 while myeloperoxidase, myeloid-related protein 8/14 and pregnancy-associated plasma protein-A are recognize markers of plaque instability. Lastly, some studies demonstrated that circulating miRNAs are involved in coronary artery disease, acute myocardial infarction and heart failure.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1502
[Da] Date of entry for processing:150220
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5493/wjem.v5.i1.21

  2 / 750549 MEDLINE  
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[PMID]: 25698387
[Au] Autor:Clemens RK; Pfammatter T; Meier TO; Alomari AI; Amann-Vesti BR
[Ad] Address:Clinic for Angiology, University Hospital Zurich, Switzerland....
[Ti] Title:Combined and complex vascular malformations.
[So] Source:Vasa;44(2):92-105, 2015 Mar.
[Is] ISSN:0301-1526
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The correct diagnosis of vascular malformations is obtainable by clinical assessment and patient history in the majority of cases. Nonetheless, confusion in nomenclature, existence of multiple classifications and rarity of these lesions leads to misdiagnosis and related wrong treatment. This is especially the case in combined or complex vascular malformations or vascular malformations that are part of syndromes as these have overlapping clinical and imaging features. New entities in the field of vascular anomalies have been described recently like fibro-adipose vascular anomaly or central conducting lymphatic anomalies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1024/0301-1526/a000414

  3 / 750549 MEDLINE  
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[PMID]: 25698273
[Au] Autor:Akman L; Hursitoglu BS; Farajov R; Terek MC; Sezak M; Simsek D; Yilmaz H
[Ad] Address:Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey. leventakman@gmail.com.
[Ti] Title:Gastrointestinal stromal tumor and leiomyoma of the ileum mimicking adnexal mass: A report of two cases.
[So] Source:Turk J Gastroenterol;26(1):56-9, 2015 Jan.
[Is] ISSN:1300-4948
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:Adnexal masses are formations seen in women of all ages; they most often include cystic elements. Medical history, physical examination, different imaging methods, and tumor marker determinations must be used together for preoperative evaluation of an adnexal mass. Both benign and malignant tumors of the small intestine are more rarely encountered than malignant tumors of other gastrointestinal system components; although advanced imaging methods and other diagnostic techniques are used, they do not always allow these tumors to be differentiated from adnexal masses. We report here on two cases operated on with the preliminary diagnosis of an adnexal mass, in which the presence of a gastrointestinal stromal tumor and a leiomyoma of the ileum, respectively, was established.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.5152/tjg.2015.3833

  4 / 750549 MEDLINE  
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[PMID]: 25301711
[Au] Autor:Fernandes FR; Zanini PB; Rezende GR; Castro LS; Bandeira LM; Puga MA; Tanaka TS; Castro LS; Bertolacci-Rocha LG; Teles SA; Motta-Castro AR
[Ad] Address:Laboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil....
[Ti] Title:Syphilis infection, sexual practices and bisexual behaviour among men who have sex with men and transgender women: a cross-sectional study.
[So] Source:Sex Transm Infect;91(2):142-9, 2015 Mar.
[Is] ISSN:1472-3263
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Men who have sex with men (MSM) and transgender women (TW) are highly vulnerable groups to sexually transmitted infections (STIs). This study aims to assess the prevalence of syphilis infection, sexual behaviour and identify factors associated with syphilis in MSM and TW in Campo Grande, Central Brazil. METHODS: Between 2009 and 2011, 430 MSM/TW participants were interviewed and tested for syphilis. Univariable and multivariable regression analyses were done to assess associations with syphilis infection. RESULTS: A total of 430 MSM/TW (278 MSM and 152 TW) were included in the study. The overall prevalence of lifetime syphilis and active syphilis was 34.7% (26.3% among MSM; 50.0% among TW) and 17.5% (12.3% among MSM; 27.0% among TW), respectively (p<0.001). In multivariable regression analysis, being 20-24 years and ≥30 years, having engaged in a variety of sexual practices and with a history of genital/anal ulcer in the last 12 months were associated with lifetime syphilis infection in the MSM group. Among TW participants, being ≥30 years of age, having more than 10 male sexual partners in last week and being infected with HIV were associated with lifetime syphilis. Factors associated with active syphilis among MSM were massage parlour/sauna recruitment and alcohol consumption at least once a week. Having sex with female partners in the past 12 months was predictive for active syphilis among TW. CONCLUSIONS: The prevalence of syphilis infection and risk sexual behaviour were high in the two samples, especially among TW. High levels of bisexual behaviours and low rates of consistent condom use indicate potential HIV/STIs transmission into the heterosexual population. This finding indicates the need and urgency for implementing more effective integrated programmes targeting MSM/TW for the prevention of syphilis and other STIs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1136/sextrans-2014-051589

  5 / 750549 MEDLINE  
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[PMID]: 25699288
[Au] Autor:Saki J; Mohammadpour N; Moramezi F; Khademvatan S
[Ad] Address:Department of Medical Parasitology and Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran....
[Ti] Title:Seroprevalence of Toxoplasma gondii in Women Who Have Aborted in Comparison with the Women with Normal Delivery in Ahvaz, Southwest of Iran.
[So] Source:ScientificWorldJournal;2015:764369, 2015.
[Is] ISSN:1537-744X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Toxoplasma gondii is an obligate intracellular protozoan parasite causing toxoplasmosis in animals and humans. Primary maternal infection with toxoplasmosis during pregnancy is frequently associated with transplacental transmission to the fetus. However it is not certain whether Toxoplasma infection can cause recurrent abortion. The aim of this study was to determine the relationship between Toxoplasma infection and abortion via detection of anti-Toxoplasma gondii antibodies in sera of women with obstetrical problems and compare the results with control group consisting of women with history of normal delivery. Sera from 130 women with abortion and sera of 130 women with normal delivery were tested for IgG and IgM anti-Toxoplasma gondii antibodies by ELISA method. The present study revealed 24.6% of the samples with abortion and 21.5% of the samples with normal delivery were positive for IgG antibodies. However, statistical analysis indicated no significant differences (P > 0.05). In addition, IgM antibody was detected in one woman who had aborted but not in women with normal childbirth. This study showed no significant difference between the case and control groups in IgG anti-Toxoplasma antibody but detected one sample with IgM antibodies in woman with abortion during the first trimester of pregnancy. In order to determine the relationship between Toxoplasma infection and abortion, anti-Toxoplasma IgG avidity and PCR to discriminate between recent and prior infections are recommended.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1155/2015/764369

  6 / 750549 MEDLINE  
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[PMID]: 25193809
[Au] Autor:Muratore F; Kermani TA; Crowson CS; Green AB; Salvarani C; Matteson EL; Warrington KJ
[Ad] Address:Division of Rheumatology, Department of Medicine, Arcispedale S. Maria Nuova IRCCS, Reggio Emilia, Italy, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, Division of Rheumatology, Department of Medicine, Divis...
[Ti] Title:Large-vessel giant cell arteritis: a cohort study.
[So] Source:Rheumatology (Oxford);54(3):463-70, 2015 Mar.
[Is] ISSN:1462-0332
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of this study was to compare baseline variables, treatment and outcomes in patients with large-vessel GCA (LV-GCA), primarily of the upper extremities, with those with cranial disease (C-GCA). METHODS: All patients >50 years of age with radiographic evidence of subclavian LV-GCA diagnosed between 1 January 1999 and 31 December 2008 were identified and compared with those with biopsy-positive C-GCA diagnosed in the same period. RESULTS: The study included 120 LV-GCA patients and 212 C-GCA patients. Compared with C-GCA, patients with LV-GCA were younger [68.2 years (s.d. 7.5) vs 75.7 (7.4), P < 0.001] and had longer duration of symptoms at GCA diagnosis (median 3.5 vs 2.2 months, P < 0.001). A history of PMR was more common in LV-GCA patients (26% vs 15%, P = 0.012), but a smaller proportion had cranial symptoms (41% vs 83%, P < 0.001) and vision loss (4% vs 11%, P = 0.035). ACR classification criteria for GCA were satisfied in 39% of LV-GCA patients and 95% of C-GCA patients (P < 0.001). Compared with C-GCA, patients with LV-GCA had more relapses (4.9 vs 3.0/10 person-years, P < 0.001), higher cumulative corticosteroid (CS) doses at 1 year [11.4 g (s.d. 5.9) vs 9.1 (s.d. 3.7), P < 0.001] and required longer treatment (median 4.5 vs 2.2 years, P < 0.001). CONCLUSION: Although patients with LV-GCA had a lower rate of vision loss, they had a higher relapse rate and greater CS requirements. The ACR criteria for GCA are inadequate for the classification of patients with LV-GCA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1093/rheumatology/keu329

  7 / 750549 MEDLINE  
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[PMID]: 25129032
[Au] Autor:Jiao J; Vincent A; Cha SS; Luedtke CA; Oh TH
[Ad] Address:Department of Physical Medicine and Rehabilitation, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
[Ti] Title:Association of abuse history with symptom severity and quality of life in patients with fibromyalgia.
[So] Source:Rheumatol Int;35(3):547-53, 2015 Mar.
[Is] ISSN:1437-160X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:A high prevalence of abuse has been reported in patients with fibromyalgia. We aimed to examine the association between self-reported abuse history and symptom severity and quality of life (QOL) in 962 patients with fibromyalgia. All patients completed the Fibromyalgia Impact Questionnaire (FIQ) and the Short Form 36 health survey (SF-36). Multivariate regression analyses were performed. In total, 289 patients (30%) reported a history of abuse. Of those who specified abuse types, 161 patients (59%) reported more than 1 type of abuse (36% emotional, 32% physical, 25% sexual, and 7% verbal). Patients in the abuse group were younger and more likely to be female, unemployed, unmarried, and current smokers compared with patients who reported no abuse. After adjusting for these differences, abuse history was associated with worse symptoms, as indicated by a higher FIQ total score (P<.001) and higher FIQ subscale scores in physical function (P=.001), work missed (P<.001), job ability (P<.001), pain (P=.02), depression (P<.001), and anxiety (P<.001). Similarly, abuse history was associated with worse QOL, with lower SF-36 scores in all domains except the physical component summary. In conclusion, abuse history in patients with fibromyalgia was associated with worse symptoms and QOL compared with those patients without abuse history. Future studies are needed to assess whether additional tailored interventions as part of fibromyalgia treatment are helpful for patients with a history of abuse.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00296-014-3113-0

  8 / 750549 MEDLINE  
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[PMID]: 25695383
[Au] Autor:Martnez-Alvarado Mdel R; Jurez-Rojas JG; Medina-Urrutia AX; Cardoso-Saldaa GC; Gonzlez-Salazar Mdel C; Posadas-Snchez R; Jorge-Galarza E; Mendoza-Prez E; Vargas-Alarcn G; Posadas-Romero C
[Ti] Title:Association of fatty liver with cardiovascular risk factors and subclinical atherosclerosis in a Mexican population.
[So] Source:Rev Invest Clin;66(5):407-14, 2014 Sep-Oct.
[Is] ISSN:0034-8376
[Cp] Country of publication:Mexico
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Individuals with fatty liver (FL) have an increased risk of coronary artery disease (CAD) probably due to its association with cardiometabolic risk factors (CMRF). OBJECTIVE: To know the prevalence of FL and analyze its association with CMRF and subclinical atherosclerosis, in a sample of Mexican Mestizo population. MATERIAL AND METHODS: This study included 846 subjects from the Genetic of Atherosclerosis Disease (GEA) study (53 9 years, 50.7% women) without diabetes and no personal or family history of premature CAD. Blood samples were taken for measurements of lipids profile, uric acid, and insulin. The presence of FL was identified by computed tomography. Carotid intima media thickness (CIMT) was measured by B mode ultrasound, using the > 75 percentile as cutoff value to define subclinical atherosclerosis. RESULTS: The general prevalence of FL was 32.4%. In men, FL was associated with hyperuricemia, whereas in women, hyperuricemia, low level of high density lipoprotein cholesterol, and metabolic syndrome were the factors associated with this hepatic alteration. In women, FL was associated with a 66% higher probability of having high CIMT, independently of age, hypertension, dyslipidemia, and waist circumference, but not of HOMA-IR. CONCLUSIONS: In women, FL was associated with the presence of subclinical atherosclerosis independently of traditional CMRF. Our study suggests that, in women, insulin resistance could be a mediator of metabolic abnormalities and of subclinical atherosclerosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 750549 MEDLINE  
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[PMID]: 25695380
[Au] Autor:Guerra-Hernndez N; Matos-Martnez M; Ordaz-Lpez KV; Camargo-Muiz MD; Medeiros M; Escobar-Prez L
[Ti] Title:Clinical and biochemical findings in Mexican patients with distal renal tubular acidosis.
[So] Source:Rev Invest Clin;66(5):386-92, 2014 Sep-Oct.
[Is] ISSN:0034-8376
[Cp] Country of publication:Mexico
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Renal tubular acidosis (RTA) is a rare disease characterized by a normal serum anion gap, sustained metabolic acidosis, low concentration of plasma bicarbonate, variable hyperchloremia and hypokalemia and conserved glomerular filtration rate. RTA is developed during the first year of life and produces failure to thrive and anorexia. Primary distal RTA (type 1) is a renal syndrome with a reduced ability to excrete the acid load through the collecting ducts and impairment to concentrate the urine causing polyuria and dehydration. OBJECTIVE: Evaluate the current health status and describe the clinical findings and progress of Mexican patients with distal RTA. Demonstrate the distal urinary acidification defect by measuring the urinary pCO2 tension in alkaline urines. MATERIAL AND METHODS: We looked for infants in tertiary care hospitals with a clinical history of normal serum anion gap, metabolic acidosis, hypokalemia, hyperchloremia, nephrocalcinosis, sensorineural hearing loss and inability for urine acidification under systemic metabolic acidosis. Biochemical analysis were performed periodically. Alkali medication was not suspended in one patient to assess urinary acidification with oral administration of sodium bicarbonate (2 mEq/Kg) and acetazolamide (500 mg/1.73 m2 body surface). Urinary pCO2 levels were determined at 60 and 90 min. RESULTS: Three children, one adolescent and one adult with distal RTA were found. They had an infant history of dehydration, failure to thrive, anorexia, vomiting, muscle paralysis, hypercalciuria, urinary infections, polyuria, polydipsia and polyhidramnios during pregnancy. Severe nephrocalcinosis was detected in all patients whereas sensorineural hearing loss was developed in four cases. Under the alkali medication all cases but one were normocalciuric. A patient developed kidney failure. The urinary acidification test confirmed the innability to eliminate the acid load. CONCLUSION: Early diagnosis in infancy and continuos alkali medication were of great benefit for most of the patients. Urinary pCO2 levels in alkaline urine provided an index for collecting duct hydrogen-ion secretion. To our knowledge this is the first report of mexican patients with distal RTA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 750549 MEDLINE  
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[PMID]: 25697616
[Au] Autor:Carrillo D; Zambrano P; Wietstruck MA; De Barbieri F; Carrillo D
[Ti] Title:Funcin renal en pacientes peditricos con trasplante alognico de progenitores hematopoyticos. [Renal function in pediatric patients with allogeneic hematopoietic progenitor cell transplantation].
[So] Source:Rev Chil Pediatr;85(6):701-7, 2014 Dec.
[Is] ISSN:0717-6228
[Cp] Country of publication:Chile
[La] Language:spa
[Ab] Abstract:UNLABELLED: Patients with hematopoietic stem cell transplantation can develop some degree of renal failure. The aim of this descriptive study is to evaluate markers of kidney injury in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation between 1991 and 2011. PATIENTS AND METHOD: A descriptive study of pediatric patients with allogeneic transplant of hematopoietic precursors between 1991 and 2011. The patients were between 1 month and 18 years of age at the time of the study and had at least 6 months of follow up. Clinical and nutritional history, continuous blood pressure monitoring (ABPM), urine tests, proteinuria, creatinine and renal and bladder ultrasonography imaging were evaluated. RESULTS: During this period 65 patients were transplanted, of which 13 patients were included. 46% (n = 6) showed diverse degrees of renal compromise defined by altered renal parenchymal echogenicity, clinic or masked hypertension and/or microalbuminuria. CONCLUSION: In this clinical group, almost half of the patients patients had some degree of renal injury in their evolution. We consider essential to assess the renal function in the follow-up of these patients.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Data-Review


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