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[PMID]: 25024628
[Au] Autor:Zhang SH; Wang LA; Li Z; Peng Y; Cun YP; Dai N; Cheng Y; Xiao H; Xiong YL; Wang D
[Ad] Address:Shi-Heng Zhang, Lin-Ang Wang, Zheng Li, Yu Peng, Yan-Ping Cun, Nan Dai, Yi Cheng, He Xiao, Yan-Li Xiong, Dong Wang, Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China....
[Ti] Title:APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans.
[So] Source:World J Gastroenterol;20(26):8700-8, 2014 Jul 14.
[Is] ISSN:2219-2840
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:AIM: To study the association between four base excision repair gene polymorphisms and colorectal cancer risk in a Chinese population. METHODS: Two hundred forty-seven colorectal cancer (CRC) patients and three hundred cancer-free controls were enrolled in this study. Four polymorphisms (OGG1 Ser326Cys, APE1 Asp148Glu, -141T/G in the promoter region, and XRCC1 Arg399Gln) in components of the base excision repair pathway were determined in patient blood samples using polymerase chain reaction with confronting two-pair primers. The baseline information included age, gender, family history of cancer, and three behavioral factors [smoking status, alcohol consumption, and body mass index (BMI)]. χ(2) tests were used to assess the Hardy-Weinberg equilibrium, the distributions of baseline characteristics, and the four gene polymorphisms between the cases and controls. Multivariate logistic regression analyses were conducted to analyze the correlations between the four polymorphisms and CRC risk, adjusted by the baseline characteristics. Likelihood ratio tests were performed to analyze the gene-behavior interactions of smoking status, alcohol consumption, and BMI on polymorphisms and CRC susceptibility. RESULTS: The APE1 148 Glu/Glu genotype was significantly associated with an increased risk of colorectal cancer (OR = 2.411, 95%CI: 1.497-3.886, P < 0.001 relative to Asp/Asp genotype). There were no associations between OGG1, XRCC1, or APE1 promoter polymorphisms and CRC risk. A multivariate analysis including three behavioral factors showed that the APE1 148 Glu/Glu genotype was associated with an increased risk for CRC among both smokers and non-smokers, non-drinkers and individuals with a BMI ≥ 25 kg/m(2) (ORs = 2.356, 3.299, 2.654, and 2.581, respectively). The XRCC1 399 Arg/Gln genotype was associated with a decreased risk of CRC among smokers and drinkers (OR = 0.289, 95%CI: 0.152-0.548, P < 0.001, and OR = 0.327, 95%CI: 0.158-0.673, P < 0.05, respectively). The APE1 promoter polymorphism -141 T/G genotype was associated with a reduced risk of colorectal cancer among subjects with a BMI < 25 kg/m(2) (OR = 0.214, 95%CI: 0.069-0.660, P < 0.05 relative to T/T genotype). There were significant gene-behavior interactions between smoking status and XRCC1 Arg399Gln, as well as BMI and APE1 -141T/G polymorphism (all P < 0.05). CONCLUSION: APE1 Asp148Glu is associated with increased CRC risk and smoking alters the association between XRCC1 Arg399Gln and CRC risk in the Chinese Han population.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3748/wjg.v20.i26.8700

  2 / 728743 MEDLINE  
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[PMID]: 24865243
[Au] Autor:Wülfing C; Humke U
[Ad] Address:Abteilung für Urologie, Asklepios Klinik Altona, Paul-Ehrlich Straße 1, 22763, Hamburg, Deutschland, c.wuelfing@asklepios.com.
[Ti] Title:Offene und minimal-invasive partielle Nephrektomie : Komplikationsmanagement. [Open and minimally invasive partial nephrectomy : Management of complications].
[So] Source:Urologe A;53(7):960-7, 2014 Jul.
[Is] ISSN:1433-0563
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:Current guidelines increasingly recommend organ-preserving surgical procedures in the treatment of renal tumors. Both the open surgical and minimally invasive surgical techniques are well established. In the literature, various systems for the systematic evaluation of comorbidities and complications have been reported. Already while taking the patient's history and preoperative planning prior to partial nephrectomy, it is recommended that a detailed risk assessment be carried out regarding expected complications. Essentially the two critical factors - the comorbidities of the patient and anatomic complexity level of the tumor - should be evaluated in order to achieve the best possible selection of patients for a partial nephrectomy and the determination of the surgical method.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00120-014-3512-6

  3 / 728743 MEDLINE  
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[PMID]: 24608735
[Au] Autor:Huang E; Shye M; Elashoff D; Mehrnia A; Bunnapradist S
[Ad] Address:1 Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA. 2 Department of Biostatistics, School of Public Health, University of California, Los Angeles, CA. 3 Address correspondence to: Edmund Huang, M.D., Kidney Transplant Research Program, UCLA David Geffen School of Medicine, 1033 Gayley Avenue, Suite 208, Los Angeles, CA 90095.
[Ti] Title:Incidence of conversion to active waitlist status among temporarily inactive obese renal transplant candidates.
[So] Source:Transplantation;98(2):177-86, 2014 Jul 27.
[Is] ISSN:1534-6080
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Candidates may be active or temporarily inactive (status 7) on the kidney transplant waiting list. One reason candidates may be inactive is for a "weight currently inappropriate for transplantation." We hypothesized that many of these candidates would not achieve active status. METHODS: Using OPTN/UNOS data from 2006 to 2012, we used competing risks methods to determine the cumulative incidence of conversion to active status (activation), death, and delisting before conversion among 1679 obese adult kidney candidates designated as status 7 because of a weight inappropriate for transplantation. Fine and Gray competing risks regression was performed to characterize factors associated with conversion to active status in the overall study population and of transplantation among a subgroup of activated candidates. RESULTS: At 6 years, the cumulative incidence of activation was 49%, of death before conversion was 15%, and of delisting was 21%. Higher body mass index (BMI) was strongly associated with a decreased subhazard of activation (BMI ≥45 versus 30-34.9, sHR: 0.22; 95% CI, 0.16-0.33). Female sex, diabetic end-stage renal disease, history of a previous transplant, panel reactive antibodies less than 80%, dialysis dependence at listing, and UNOS region 5 were negatively associated with activation. Among activated candidates, the cumulative incidence of transplantation at 6 years after initial waitlisting was 61%. CONCLUSION: Our findings indicate that half of obese status 7 candidates with a weight inappropriate for transplantation will not achieve active waitlist status. BMI at listing had a strong association with conversion to active status; comorbid factors and regional variation also impact activation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/TP.0000000000000037

  4 / 728743 MEDLINE  
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[PMID]: 25024890
[Au] Autor:Azab WA; Shohoud SA; Alsheikh TM; Nasim K
[Ad] Address:Department of Neurosurgery, Ibn Sina Hospital, Kuwait City, PO Box 25427, Safat 13115, Kuwait....
[Ti] Title:John Edwin Scarff (1898-1978) and endoscopic choroid plexus coagulation: A historical vignette.
[So] Source:Surg Neurol Int;5:90, 2014.
[Is] ISSN:2229-5097
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:John Edwin Scarff (1898-1978) was one of the pioneers of neuroendoscopy and the head of the Department of Neurological Surgery at Columbia University in New York from 1947 to 1949. In this article, we highlight the pioneering and longstanding efforts of John E. Scarff in support of endoscopic choroid plexus coagulation. These efforts represent an important part of the rich history of neuroendoscopy and a legacy to which the current procedure owes a great credit.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1407
[Da] Date of entry for processing:140715
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/2152-7806.134106

  5 / 728743 MEDLINE  
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[PMID]: 25024891
[Au] Autor:Duenas M; Whyte G; Jandial R
[Ad] Address:Department of Neurosurgery, City of Hope Cancer Center, Beckmann Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA.
[Ti] Title:Sideline concussion testing in high school football on Guam.
[So] Source:Surg Neurol Int;5:91, 2014.
[Is] ISSN:2229-5097
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:BACKGROUND: The risks of repeat concussions and returning to play (RTP) prior to the resolution of concussive symptoms are medically established. However, RTP guidelines for high school sports are varied and often notably absent. The island of Guam, a US territory, has a robust athletics program but lacks structure to reduce concussions or establish RTP protocols. Consequently, there is an opportunity to limit the incidence of "second-hit syndrome" and other harmful effects through education and testing. METHODS: We evaluated the feasibility of Sideline Concussion Testing SCT) as a novel feature of Guam high school athletics. Thirteen high school football players were observed over three consecutive football games. They were first given a questionnaire about concussion history, symptoms, medical evaluation, and RTP. Researchers used the King-Devick Test, a SCT tool, and baseline scores were recorded. If players were then observed to have significant head trauma or to show concussive symptoms, they were sidelined and tested. RESULTS: Five of 13 students had a previous concussion and limited awareness of RTP guidelines. Of those five, four received no medical consultation or stand down period before RTP. There was also a lack of understanding of what constitutes a concussion; five out of eight individuals who denied previous concussion confirmed having bell ringers, seeing stars, and other classic concussive symptoms. Over the course of the study the SCT identified three concussions, with significant deviations from baseline time on a test that measured visual and speech disturbances. CONCLUSIONS: The feasibility of SCT use in Guam high school football was established and our pilot study identified areas for improvement. Established definitions of concussion and RTP guidelines were lacking. Therefore, an opportunity exists through public health efforts that involve the entire community to increase concussion awareness and reduce injuries in high school sports on Guam.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Da] Date of entry for processing:140715
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/2152-7806.134364

  6 / 728743 MEDLINE  
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[PMID]: 25023355
[Au] Autor:Pasche B; Wang M; Pennison M; Jimenez H
[Ad] Address:Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University, Medical Center Blvd, Winston Salem, NC. Electronic address: bpasche@wakehealth.edu....
[Ti] Title:Prevention and treatment of cancer with aspirin: where do we stand?
[So] Source:Semin Oncol;41(3):397-401, 2014 Jun.
[Is] ISSN:1532-8708
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Aspirin is arguably the synthesized drug that has been used most commonly in human history. Aspirin was originally developed and marketed for the treatment of inflammatory disorders at the end of the 19th century, but its mechanism of action remained unknown until the second half of the 20th century. Since the latter part of the 20th century aspirin also has been used for the primary and secondary prevention of cardiovascular diseases given its anti-thrombotic properties. An association between intake of aspirin and decreased cancer risk was identified in the past decades. Whether aspirin can be used as an anticancer agent in patients with a diagnosis of cancer was unknown until recently. Recent studies suggest that aspirin might provide therapeutic benefit in the adjuvant treatment of certain forms of cancer. This review provides a critical update on this topic, which has potential implications for oncologists and their patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 728743 MEDLINE  
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[PMID]: 25022313
[Au] Autor:Tiberti MM; Basili R; Vannoli P
[Ad] Address:Istituto Nazionale di Geofisica e Vulcanologia, Via di Vigna Murata 605, 00143 Rome, Italy.
[Ti] Title:Ups and downs in western Crete (Hellenic subduction zone).
[So] Source:Sci Rep;4:5677, 2014.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Studies of past sea-level markers are commonly used to unveil the tectonic history and seismic behavior of subduction zones. We present new evidence on vertical motions of the Hellenic subduction zone as resulting from a suite of Late Pleistocene - Holocene shorelines in western Crete (Greece). Shoreline ages obtained by AMS radiocarbon dating of seashells, together with the reappraisal of shoreline ages from previous works, testify a long-term uplift rate of 2.5-2.7 mm/y. This average value, however, includes periods in which the vertical motions vary significantly: 2.6-3.2 mm/y subsidence rate from 42 ka to 23 ka, followed by ~7.7 mm/y sustained uplift rate from 23 ka to present. The last ~5 ky shows a relatively slower uplift rate of 3.0-3.3 mm/y, yet slightly higher than the long-term average. A preliminary tectonic model attempts at explaining these up and down motions by across-strike partitioning of fault activity in the subduction zone.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1038/srep05677

  8 / 728743 MEDLINE  
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[PMID]: 24697345
[Au] Autor:Zhengyong Y; Changxiao H; Shibing Y; Caiwen W
[Ad] Address:Department of Urology, Dujiangyan Medical Center , Dujiangyan , PR China.
[Ti] Title:Randomized controlled trial on the efficacy of bladder training before removing the indwelling urinary catheter in patients with acute urinary retention associated with benign prostatic hyperplasia.
[So] Source:Scand J Urol;48(4):400-4, 2014 Aug.
[Is] ISSN:2168-1813
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Abstract Objective.The aim of this study was to investigate the efficacy of bladder training before removing the indwelling urinary catheter in patients with acute urinary retention (AUR) associated with benign prostatic hyperplasia (BPH). Material and methods. In total, 845 consecutive patients with their first episode of spontaneous AUR associated with BPH were enrolled in this prospective randomized controlled trial. They were randomly assigned to be given either pharmacological treatment combined with bladder training or pharmacological treatment (tamsulosin 0.2 mg and finasteride 5 mg once daily) with free drainage of urinary catheter for 7 days, and a trial without catheter (TWOC) was performed. Data on patients' baseline demographics, history of BPH, International Prostate Symptom Score, prostate size, serum prostate-specific antigen, intravesical prostatic protrusion, TWOC success rates and related complications were collected and statistically analysed. Results.The two groups of spontaneous AUR patients with BPH were given pharmacological treatment combined with bladder training before catheter removal (n = 440) or pharmacological treatment alone (n = 405) for 7 days. All 845 patients underwent a first TWOC with an overall success rate of 66.9% after first 7 days' catheterization; TWOC was successful in 65.2% of cases in the intervention group and 68.6% in the control group. There was no statistically significant difference in TWOC success rate between the two groups (p > 0.05). Conclusion. This randomized controlled trial showed that bladder training before urinary catheter removal did not increase the chance of TWOC success significantly in spontaneous AUR patients with BPH.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3109/21681805.2014.903512

  9 / 728743 MEDLINE  
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[PMID]: 24521184
[Au] Autor:Tuncel A; Keten T; Aslan Y; Kayali M; Erkan A; Koseoglu E; Atan A
[Ad] Address:Third Department of Urology, Ankara Numune Research and Training Hospital, Ministry of Health , Ankara , Turkey.
[Ti] Title:Comparison of different scoring systems for outcome prediction in patients with Fournier's gangrene: Experience with 50 patients.
[So] Source:Scand J Urol;48(4):393-9, 2014 Aug.
[Is] ISSN:2168-1813
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Abstract Objective. The aim of this study was to evaluate effective factors in the survival of patients with Fournier's gangrene (FG) and compare three different validated scoring systems for outcome prediction: Fournier's Gangrene Severity Index (FGSI), Uludag Fournier's Gangrene Severity Index (UFGSI) and age-adjusted Charlson Comorbidity Index (ACCI). Material and methods. Fifty men who underwent surgery for FG between July 2005 and August 2012 were included in the study. Data were collected on medical history, symptoms, physical examination findings, vital signs, admission and final laboratory tests, timing and extent of surgical debridement, and antibiotic treatment used. The FGSI, UFGSI and ACCI were evaluated stratified by survival. Admission and final parameters were measured using the Mann-Whitney test. Results. The results were evaluated for two groups: survivors (n = 43) and non-survivors (n = 7). Survivors were younger than non-survivors (median age 58 vs 68.5 years, p = 0.017). The median extent of body surface area involved in the necrotizing process in patients who survived and did not survive was 2.3% and 4.8%, respectively (p = 0.04). No significant differences in laboratory parameters were found between survivors and non-survivors at the time of admission, except for haemoglobin, haematocrit, serum urea and albumin levels. Only UFGSI, but not FGSI or ACCI, had any meaning or predictive value in disease severity or patients' survival. Conclusion. Only the UFGSI score could predict the disease severity and the patients' survival. The findings did not support previous findings that an UFGSI threshold of 9 is a predictor of mortality during initial evaluation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3109/21681805.2014.886289

  10 / 728743 MEDLINE  
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[PMID]: 25012824
[Au] Autor:Nunes RA; Cade JR; Silva RC; Brito Júnior FS; Freitas HF
[Ad] Address:Department of Cardiology, Hospital São Camilo Santana, São Paulo, Brazil; Heart Institute (InCor), University of São Paulo Medical School, Brazil. Electronic address: rafael.nunes@incor.usp.br....
[Ti] Title:Spontaneous closure of post-intervention left anterior descending coronary pseudoaneurysm.
[So] Source:Rev Port Cardiol;33(6):381.e1-4, 2014 Jun.
[Is] ISSN:2174-2030
[Cp] Country of publication:Portugal
[La] Language:eng; por
[Ab] Abstract:Coronary pseudoaneurysms are an unusual finding during coronary angiography and there are very little data on their prognosis in the literature. We report the case of a 62-year-old man admitted with an anterior myocardial infarction who developed a pseudoaneurysm in the mid left anterior descending artery some days after a type I coronary perforation during coronary angioplasty. Spontaneous closure of the pseudoaneurysm was observed during hospital follow-up. Spontaneous closure of coronary pseudoaneurysms may be more common in clinical practice than previously thought, but few cases have been reported. As the natural history of post-intervention coronary pseudoaneurysms has been little investigated, reports of their occurrence may help to clarify their evolution.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review


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