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[PMID]: 29186970
[Au] Autor:Shchetynina A; Budzanivska I; Pereboychuk O; Sõmera M; Truve E
[Ti] Title:First report of Hosta virus X infecting hosta plants in Ukraine.
[So] Source:Acta Virol;61(4):498-499, 2017.
[Is] ISSN:0001-723X
[Cp] Country of publication:Slovakia
[La] Language:eng
[Ab] Abstract:In September 2011, the leaf samples of hosta cultivar 'Sum and substance' were collected from the collection of Gryshko' National Botanical Garden in Kyiv. The leaves showed dark green streaking and puckering along the leaf veins. Transmission electron microscopy revealed the presence of filamentous viral particles 13 nm in diameter and 470-580 nm in length. Reverse transcription PCR (RT-PCR) analysis confirmed the presence of Hosta virus X (HVX). The sequencing of the complete genome revealed 99% identity to HVX-37 and 97.5% identity to HVX-Kr. Notably, ORF4 initiation codon presented a non-conventional start codon (UUG) like it was previously identified in HVX-37.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:In-Process
[do] DOI:10.4149/av_2017_415

  2 / 69 MEDLINE  
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[PMID]: 29390913
[Au] Autor:He J; Huang X; Wang Y; Liang J; Liu R; Zhong G; Yang L
[Ad] Address:a Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine , Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
[Ti] Title:A new flavonol glycoside from the flowers of Hosta plantaginea with cyclooxygenases-1/2 inhibitory and antioxidant activities.
[So] Source:Nat Prod Res;:1-6, 2018 Feb 02.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Hosta plantaginea was a traditional Chinese medicinal plants used to treat inflammatory and painful diseases with partial scientific validation. Solvent extractions followed by repeated chromatographic purification of the H. plantaginea flowers led to the isolation of one new flavonoid glycoside, hostaflavone A (1), together with one related known compound, kaempferol-3-O-sophoroside-7-O-glucoside (2), and their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. Compounds 1 and 2 were evaluated for the anti-inflammatory activites against cyclooxygenases (COX-1 and COX-2) and DPPH free radical-scavenging activities in vitro. The results revealed that 1 and 2 exhibited significant COX-1 inhibition and moderate COX-2 inhibition compared to the reference celecoxib. Additionally, 1 and 2 displayed insignificant antioxidant activities compared to the positive control L-ascorbic acid.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180202
[Lr] Last revision date:180202
[St] Status:Publisher
[do] DOI:10.1080/14786419.2018.1428591

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[PMID]: 29072626
[Au] Autor:Yang L; Jiang ST; Zhou QG; Zhong GY; He JW
[Ad] Address:Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China. yangli07971@163.com.
[Ti] Title:Chemical Constituents from the Flower of Hosta plantaginea with Cyclooxygenases Inhibition and Antioxidant Activities and Their Chemotaxonomic Significance.
[So] Source:Molecules;22(11), 2017 Oct 26.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Two new phenolic glucosides, hostaflavanone A ( ) and -1-phenylpropane-1,2-diol-2- -ß-d-glucopyranoside ( ), together with six known compounds, -1-phenylpropane-1,2-diol ( ), phenethyl- -ß-d-glucopyranoside ( ), phenethanol-ß-d-gentiobioside ( ), phenethyl- -rutinoside ( ), (1 , 3 )-1-methyl-1,2,3,4-tetrahydro-ß-carboline-3-carboxylic acid ( ), and (1 , 3 )-1-methyl-1,2,3,4-tetrahydro-ß-carboline-3-carboxylic acid ( ), were isolated from the flower of , and their structures were elucidated by nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HRESIMS), and circular dichroism (CD) analyses. The cyclooxygenases (COX-1 and COX-2) inhibition and antioxidant activities of compounds and - were investigated, and they showed moderate cyclooxygenases inhibition activities. Moreover, only compound exhibited moderate antioxidant activity, with an IC value of 83.2 µM, while - showed insignificant activity with IC values of 282, 257, and 275 µM, respectively. This is the first report of compounds and - from the Liliaceae family. The chemotaxonomic significance of the isolated compounds was also summarized.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171026
[Lr] Last revision date:171026
[St] Status:In-Process

  4 / 69 MEDLINE  
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[PMID]: 28792680
[Au] Autor:Burghardt LT; Guhlin J; Chun CL; Liu J; Sadowsky MJ; Stupar RM; Young ND; Tiffin P
[Ad] Address:Department of Plant and Microbial Biology, University of Minnesota, St. Paul, MN, USA.
[Ti] Title:Transcriptomic basis of genome by genome variation in a legume-rhizobia mutualism.
[So] Source:Mol Ecol;26(21):6122-6135, 2017 Nov.
[Is] ISSN:1365-294X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In the legume-rhizobia mutualism, the benefit each partner derives from the other depends on the genetic identity of both host and rhizobial symbiont. To gain insight into the extent of genome × genome interactions on hosts at the molecular level and to identify potential mechanisms responsible for the variation, we examined host gene expression within nodules (the plant organ where the symbiosis occurs) of four genotypes of Medicago truncatula grown with either Ensifer meliloti or E. medicae symbionts. These host × symbiont combinations show significant variation in nodule and biomass phenotypes. Likewise, combinations differ in their transcriptomes: host, symbiont and host × symbiont affected the expression of 70%, 27% and 21%, respectively, of the approximately 27,000 host genes expressed in nodules. Genes with the highest levels of expression often varied between hosts and/or symbiont strain and include leghemoglobins that modulate oxygen availability and hundreds of Nodule Cysteine-Rich (NCR) peptides involved in symbiont differentiation and viability in nodules. Genes with host × symbiont-dependent expression were enriched for functions related to resource exchange between partners (sulphate/iron/amino acid transport and dicarboxylate/amino acid synthesis). These enrichments suggest mechanisms for host control of the currencies of the mutualism. The transcriptome of M. truncatula accession HM101 (A17), the reference genome used for most molecular research, was less affected by symbiont identity than the other hosts. These findings underscore the importance of assessing the molecular basis of variation in ecologically important traits, particularly those involved in biotic interactions, in multiple genetic contexts.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[St] Status:In-Process
[do] DOI:10.1111/mec.14285

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[PMID]: 28696039
[Au] Autor:Yun SJ; Lee JY; Kim GH; Kim TH; Lee AY; Lee SH; Hong JS
[Ad] Address:Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea.
[Ti] Title:Systemic contact dermatitis induced by roots of Hosta plantaginea.
[So] Source:J Eur Acad Dermatol Venereol;, 2017 Jul 11.
[Is] ISSN:1468-3083
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1707
[Cu] Class update date: 170802
[Lr] Last revision date:170802
[St] Status:Publisher
[do] DOI:10.1111/jdv.14469

  6 / 69 MEDLINE  
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[PMID]: 28577193
[Au] Autor:Cao GX; Wu BX; Xu XJ; Wang X; Yang CP
[Ad] Address:Department of Forestry, Sichuan Agricultural University, Chengdu, 611130, China. cgxing@sicau.edu.cn.
[Ti] Title:The effects of local variation in light availability on pollinator visitation, pollen and resource limitation of female reproduction in Hosta ventricosa.
[So] Source:Bot Stud;58(1):24, 2017 Dec.
[Is] ISSN:1817-406X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Light availability may have direct effects on reproduction through resource availability, and indirect effects on female reproduction by influencing plant-pollinator interactions. Floral display size, pollinator visitation per flower, resource and pollen limitation of fruit and seed production were quantified in a forested patch and an adjacent open patch of two populations of the perennial herb Hosta ventricosa. RESULTS: Plants in the open patch produced significantly larger floral displays than those in the forested patch in both populations. Floral display size had a positive effect on pollinator visitation rate per flower in one population, but no effect in the other. Plants in the open patch received approximately 8-11 times more visitation rates and produced significantly more fruit and seeds per flower than those in the forested patch. However, supplemental pollination resulted in significantly more fruit and seed production per flower compared to natural pollination in the forested patch but not in the open patch in one population, and did not enhance fruit and seed production in either the forested or the open patch in the other. In both populations, supplementally pollinated plants in the open patch produced significantly more fruit and seeds per flower than supplementally pollinated plants in the forested patch. CONCLUSIONS: In H. ventricosa, local variation in light conditions could affect pollinator activity and influence female reproduction through resource availability; however differences in the degree of pollen limitation between local habitats were found to be population-specific.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/s40529-017-0180-z

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[PMID]: 28534424
[Au] Autor:Wang MY; Peng Y; Peng CS; Qu JY; Li XB
[Ad] Address:a School of Pharmacy , Shanghai Jiao Tong University , Shanghai 200240 , China.
[Ti] Title:The bioassay-guided isolation of antifungal saponins from Hosta plantaginea leaves.
[So] Source:J Asian Nat Prod Res;:1-9, 2017 May 23.
[Is] ISSN:1477-2213
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Four new steroidal saponins hostaside â…  (1), hostaside â…¡ (2), hostaside â…¢ (3), and hostaside â…£ (4), together with five known steroidal saponins (5-9), were isolated by the bioassay-guided fractionation from the leaves of Hosta plantaginea (Lam.) Aschers, a worldwide well-known ornamental plant. Hostasides â…  and â…¡ showed significant antifungal activities, and they could inhibit the growth of Candida albicans and Fusarium oxysporium with MIC values as low as 4 µg/ml.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170620
[Lr] Last revision date:170620
[St] Status:Publisher
[do] DOI:10.1080/10286020.2017.1329304

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[PMID]: 28366208
[Au] Autor:Ghosh P; Banerjee P
[Ad] Address:Surface Engineering and Tribology Division, CSIR-Central Mechanical Engineering Research Institute, Mahatma Gandhi Avenue, Durgapur 713209, District: Burdwan, West Bengal, India.
[Ti] Title:Small molecular probe as selective tritopic sensor of Al , F and TNP: Fabrication of portable prototype for onsite detection of explosive TNP.
[So] Source:Anal Chim Acta;965:111-122, 2017 May 01.
[Is] ISSN:1873-4324
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Schiff base organic compound (SOC) has been prepared as a tritopic chemosensor for selective sensing by fluorescence signalling towards ions like Al , F and explosive molecule like TNP. In general, fluorescence like photophysical property has been used for selective detection of analyte where Al and F show turn-on fluorescence signal at different wavelengths (nm) however, quenching was found with TNP. As a consequence, the chemosensor has become a selective sensor for Al , F and TNP. Reversibility of fluorescence responses for Al and F are observed in presence of ammonium nitrate and H respectively. Similar to the detection of TNP, the detection of explosive like NO salts is also essential from homeland security point of view. In the present work, the finding of reversible sequential fluorescence response can be promoted for fabrication of next generation AND-NOT-OR-NAND-XOR-XNOR-NOR based complex logic circuit which is applicable in photonics, security and other fields including inorganic and material science. In the case of TNP recognition, the pathway mainly depends on non-covalent interaction (quenching constant: 4.4 × 10 M ) which is even better than the recently reported materials. Detection limit for Al , F and TNP is 1 µM, 3 µM and 500 nM respectively. DFT-D3 has been carried out to explore the host⋯guest interaction along with the structure-property correlation of the present host-guest system. All three guest analytes have been detected inside the living cell at a certain level and in its consequence, the successful in vitro recognition ability of the SOCs inside human cell line HeLa has been explored too. In real time stepping, an easy to operate and an economically affordable pocket prototype has also been fabricated for on spot detection of TNP like explosive.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170403
[Lr] Last revision date:170403
[St] Status:In-Data-Review

  9 / 69 MEDLINE  
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[PMID]: 28157174
[Au] Autor:Rahman MM; McFadden G
[Ad] Address:The Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ 85287-5401, USA. Masmudur.Rahman@asu.edu.
[Ti] Title:Myxoma Virus dsRNA Binding Protein M029  Inhibits the Type I IFN-Induced Antiviral State in a  Highly Species-Specific Fashion.
[So] Source:Viruses;9(2), 2017 Feb 02.
[Is] ISSN:1999-4915
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Myxoma virus (MYXV) is Leporipoxvirus that possesses a specific rabbit-restricted host tropism but exhibits a much broader  cellular host range in cultured cells. MYXV is able to efficiently  block all aspects of the type I interferon (IFN)-induced  antiviral  state  in rabbit cells, partially in  human  cells  and  very  poorly  in  mouse  cells.  The mechanism(s) of this species-specific inhibition of  type I IFN-induced antiviral state is not well understood. Here we demonstrate that MYXV encoded  protein  M029, a truncated relative of the vaccinia virus (VACV) E3 double-stranded RNA (dsRNA)  binding  protein  that  inhibits  protein  kinase  R (PKR),  can  also  antagonize the type I IFN-induced  antiviral state in a highly species-specific manner. In cells pre-treated with type I IFN prior to  infection,  MYXV  exploits  M029  to  overcome  the  induced  antiviral  state completely in rabbit cells,  partially  in  human  cells,  but  not at all in mouse cells. However, in cells pre-infected with MYXV,  IFN-induced  signaling  is fully  inhibited  even  in the  absence  of M029 in cells from all three species,  suggesting  that  other  MYXV  protein(s)  apart  from  M029  block  IFN  signaling  in  a  speciesindependent  manner.  We  also  show  that  the  antiviral  state  induced in rabbit, human or mouse cells  by  type  I IFN  can  inhibit M029-knockout MYXV even when PKR is genetically knocked-out, suggesting  that  M029  targets  other  host  proteins  for  this  antiviral state inhibition. Thus, the MYXV  dsRNA  binding  protein  M029  not  only  antagonizes  PKR  from  multiple  species  but  also blocks the  type I IFN antiviral state independently of PKR in a highly species-specific fashion.
[Mh] MeSH terms primary: Host-Pathogen Interactions
Immune Evasion
Interferon Type I/antagonists & inhibitors
Myxoma virus/pathogenicity
RNA-Binding Proteins/metabolism
Viral Proteins/metabolism
[Mh] MeSH terms secundary: Animals
Cell Line
Humans
Mice
Rabbits
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Interferon Type I); 0 (RNA-Binding Proteins); 0 (Viral Proteins)
[Em] Entry month:1709
[Cu] Class update date: 170926
[Lr] Last revision date:170926
[Js] Journal subset:IM
[Da] Date of entry for processing:170204
[St] Status:MEDLINE

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[PMID]: 27832584
[Au] Autor:Clancy DM; Martin SJ
[Ad] Address:Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland.
[Ti] Title:Getting a gRIP on Flu by Casting the DAI.
[So] Source:Cell Host Microbe;20(5):552-554, 2016 11 09.
[Is] ISSN:1934-6069
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Influenza A initiates host cell death through unknown mechanisms. Thapa et al. (2016) in this issue of Cell Host & Microbe, along with recent work by Kuriakose et al. (2016), indicate that this virus provokes divergent modes of cell death, including apoptosis and necroptosis, via the nucleic acid sensor, DAI.
[Mh] MeSH terms primary: Cell Death
Influenza A virus
Necrosis
[Mh] MeSH terms secundary: Apoptosis
[Pt] Publication type:JOURNAL ARTICLE; COMMENT
[Em] Entry month:1709
[Cu] Class update date: 171117
[Lr] Last revision date:171117
[Js] Journal subset:IM
[Da] Date of entry for processing:161111
[St] Status:MEDLINE


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