Database : MEDLINE
Search on : iridocorneal and endothelial and syndrome [Words]
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[PMID]: 29450365
[Au] Autor:Zemba M; Camburu G
[Ad] Address:Ophthalmology Department, "Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest, Romania.
[Ti] Title:Uveitis-Glaucoma-Hyphaema Syndrome. General review.
[So] Source:Rom J Ophthalmol;61(1):11-17, 2017 Jan-Mar.
[Is] ISSN:2457-4325
[Cp] Country of publication:Romania
[La] Language:eng
[Ab] Abstract:Uveitis-Glaucoma-Hyphaema Syndrome (UGH syndrome, or "Ellingson" Syndrome) is a rare condition caused by the mechanical trauma of an intraocular lens malpositioned over adjacent structures (iris, ciliary body, iridocorneal angle), leading to a spectrum of iris transillumination defects, microhyphaemas and pigmentary dispersion, concomitant with elevated intraocular pressure (IOP). UGH Syndrome can also be characterized by chronic inflammation, secondary iris neovascularization, cystoid macular edema (CME). The fundamental step in the pathogenesis of UGH syndrome appears to arise from repetitive mechanical iris trauma by a malpositioned or subluxed IOL. These patients have uncomplicated cataract implants and return for episodes of blurry vision weeks to months after surgery. This may be accompanied by pain, photophobia, erythropsia, anterior uveitis, hyphaema along with raised intraocular pressure. A careful history and examination, as well as appropriate investigations can confirm the diagnostic. Treatment options are IOL Explantation exchange, topical and systemic medication, and cyclophotocoagulation, the placement of a Capsular Tension Ring to redistribute zonular tension and Anti-vascular endothelial growth factor (anti-VEGF) Therapy.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:In-Process

  2 / 204 MEDLINE  
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[PMID]: 29331589
[Au] Autor:Silva L; Najafi A; Suwan Y; Teekhasaenee C; Ritch R
[Ad] Address:Einhorn Clinical Research Center, The New York Eye and Ear Infirmary of Mount Sinai. 310 East 14th Street. South building. Suite 304. New York, NY 10003. Electronic address: lsilva@nyee.edu.
[Ti] Title:The Iridocorneal Endothelial Syndrome.
[So] Source:Surv Ophthalmol;, 2018 Jan 10.
[Is] ISSN:1879-3304
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The iridocorneal endothelial syndrome (ICE) represents a unique group of ocular pathologies (Chandler syndrome, progressive iris atrophy, and Cogan-Reese syndrome) characterized by the proliferation of corneal endothelial cells that migrate toward the iridocorneal angle and iris surface causing, to a degree varying according to the subtype, corneal edema and decompensation, and secondary glaucoma, whether by obstructing the angle or producing peripheral anterior synechiae by contraction of the basement membrane of the migrating cells over the surface of the iris. A triggering factor, possibly viral, induces the corneal endothelial cells to proliferate and behave like epithelial cells. Diagnosis is made based on typical ocular findings on the cornea and iris. ICE is more frequent in young women, with unilateral involvement in most cases. In-vivo confocal microscopy is an excellent diagnostic tool, especially in borderline presentations like early cases of Chandler syndrome, which affects the cornea predominantly.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180114
[Lr] Last revision date:180114
[St] Status:Publisher

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[PMID]: 29317068
[Au] Autor:Li F; Liu Y; Sun Y; Zhang X
[Ad] Address:Zhongshan Ophthalmic Center, The State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China.
[Ti] Title:Etiological mechanism of iridocorneal endothelial (ICE) syndrome may involve infection of herpes simplex virus (HSV) and integration of viral genes into human genome.
[So] Source:Med Hypotheses;110:50-52, 2018 Jan.
[Is] ISSN:1532-2777
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Iridocorneal (ICE) syndrome is a rare ocular disease characterized by abnormal proliferation of corneal endothelial cells, progressive obstruction of irido-corneal angle and atrophy of iris. ICE syndrome progressed slowly, but can cause serious complications such as secondary glaucoma in late stage. Because the etiology of ICE syndrome is not clear, there is still no effective treatment in clinical practice. Previous studies have detected herpes simplex virus (HSV) DNA inside patient's aqueous humor. However, no further explanation for HSV-related etiology of ICE syndrome was established. Besides, construction of animal models using HSV all failed, leaving behind a blank space about how HSV infection finally led to ICE syndrome. By summarizing findings from previous studies, we came up with a hypothesis about etiology of ICE syndrome: HSV infection initiated ICE syndrome by integration of viral genetic material into human genome. Infection of HSV changed activity and morphology of endothelial cells, making them regain the ability of mitosis. Proof of such hypothesis will provide a theoretical foundation for construction of animal models and effective intervention of the disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180110
[Lr] Last revision date:180110
[St] Status:In-Process

  4 / 204 MEDLINE  
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[PMID]: 29243737
[Au] Autor:Ao M; Feng Y; Xiao G; Xu Y; Hong J
[Ad] Address:Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
[Ti] Title:Clinical outcome of Descemet stripping automated endothelial keratoplasty in 18 cases with iridocorneal endothelial syndrome.
[So] Source:Eye (Lond);, 2017 Dec 15.
[Is] ISSN:1476-5454
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PurposeTo evaluate the clinical outcome of Descemet stripping automated endothelial keratoplasty (DSAEK) in eyes with iridocorneal endothelial (ICE) syndrome.Patients and methodsA retrospective case series study was conducted. Eighteen consecutive Chinese patients with 20 DSAEK grafts were enrolled. Participants were evaluated by anterior segment optical coherence tomography and confocal microscopy. Postoperative complications, graft survival, endothelial cell counts, corneal thickness, and anterior chamber depth were analysed. A Log-rank test in a Kaplan-Meier analysis and a Cox proportional hazard regression were used to analyse potential risk factors of graft failure.ResultsThe mean follow-up duration was 19.0±8.6 months. The donors' endothelial cell density (ECD) (cells/mm ) values at 1, 3, 6, 12, 18, and 24 months were 3342.2±287.0, 1897.6±745.4, 1793.6±755.7, 1618.1±604.3, 1421.9±650.8, 1265.1±844.1, and 1148.2±1217.8, respectively. Eleven of the 20 grafts exhibited secondary graft failure, with a mean estimated graft survival of 23.4 months. Immediate postoperative complications (air bubble ventilation for elevated intraocular pressure or rebubbling for graft detachment) were more common in eyes exhibiting graft failure (P=0.040). Postkeratoplasty glaucoma surgery emerged as a risk factor of graft failure, with a hazard ratio of 5.174. Eyes with a poor prognosis showed statistically greater central corneal thickness at 1 month, greater graft thickness at 3 months, and a shallower anterior chamber at 6 and 12 months.ConclusionsThe long-term outcome of DSAEK in eyes with ICE syndrome is relatively poor. Immediate postoperative complications, postkeratoplasty glaucoma surgery, thicker corneal parameters, and a shallow anterior chamber were all associated with graft failure.Eye advance online publication, 15 December 2017; doi:10.1038/eye.2017.282.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171215
[Lr] Last revision date:171215
[St] Status:Publisher
[do] DOI:10.1038/eye.2017.282

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[PMID]: 28993974
[Au] Autor:Feng B; Tang X; Chen H; Sun X; Wang N
[Ad] Address:Beijing MEM Eye Care System, No. 65-2, Fuxing Road, Beijing, 100036, China.
[Ti] Title:Unique variations and characteristics of iridocorneal endothelial syndrome in China: a case series of 58 patients.
[So] Source:Int Ophthalmol;, 2017 Oct 10.
[Is] ISSN:1573-2630
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:PURPOSE: Iridocorneal endothelial (ICE) syndrome is a rare condition, and unique characteristics in Chinese patients can make diagnosis difficult. Our purpose was to describe the clinical characteristics and variations of ICE syndrome in 58 consecutive Chinese patients. METHODS: The clinical data of consecutive patients with ICE syndrome who were seen between 2008 and 2011 at the glaucoma clinic of our ophthalmology department were retrospectively reviewed. The diagnostic criteria for ICE syndrome were a "hammered-silver" appearance of the corneal endothelium and specular microscopy showing ICE cells characterized by the absence of a hexagonal appearance, dark areas within the cells, and a light-dark reversal pattern. The general characteristics of the cornea, iris, pupil, and anterior chamber angles were compiled and examined. RESULTS: Fifty-eight patients with ICE syndrome were identified: 26 had Chandler's syndrome (CS), 23 Cogan-Reese syndrome, and nine progressive iris atrophy (PIA). The incidence of glaucoma was 98%. Twenty-three (39.7%) patients had atypical ICE syndrome. Intraocular pressure was relatively high in 13 patients with slightly damaged irises, while the corneal endothelium remained relatively intact. Slit lamp examination showed an intact iris in ten patients (17.2%), with massive deposition of black pigment in the anterior chamber angle. In the 25 patients in whom the anterior chamber angle was only partially closed, 80% of the anterior chamber angles were hyperpigmented. CONCLUSIONS: CS is the most common variation of ICE syndrome in Chinese patients, and PIA is the least common. A slight change or an intact iris under slit lamp examination is a characteristic of ICE syndrome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171010
[Lr] Last revision date:171010
[St] Status:Publisher
[do] DOI:10.1007/s10792-017-0712-2

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[PMID]: 28282413
[Au] Autor:Chandran P; Rao HL; Mandal AK; Choudhari NS; Garudadri CS; Senthil S
[Ad] Address:VST Glaucoma Centre, L V Prasad Eye Institute, Hyderabad, Telangana, India.
[Ti] Title:Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects.
[So] Source:PLoS One;12(3):e0171884, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report the demographic profile, clinical features, and prevalence of glaucoma and its management in patients with Iridocorneal endothelial (ICE) syndrome. METHODS: Retrospective review of 203 consecutive subjects with ICE syndrome at a tertiary eye care centre between January 1988 and June 2013. RESULTS: ICE syndrome was present in 223 eyes of 203 subjects, 124 (61%) were female and 79 (39%) were male. The median age at presentation was 43 years (1st (Q1) and 3rd (Q3) quartile; 34, 51 years). ICE syndrome was unilateral in 183 (90%) subjects, and bilateral in 20 (10%) subjects. The most common clinical variant was progressive iris atrophy (PIA, 115; 52% eyes), followed by Chandler syndrome (CS, 87; 39% eyes) and Cogan-Reese syndrome (CRS, 21; 9% eyes). Glaucoma was found in 156 eyes (70%) at presentation and the median (Q1, Q3) intraocular pressure in eyes with glaucoma was 24 (16, 38) mm Hg. Seven eyes developed glaucoma during the follow-up period, increasing the percentage of eyes with glaucoma to 73%. Intraocular pressure was managed medically in 81 eyes (50%) and the other 82 eyes (50%) required surgical intervention. Corneal edema was present in 124 eyes (56%) of which, 32 eyes (14%) required keratoplasty. CONCLUSIONS: In our study on ICE syndrome in Indian population, the presentation was predominantly uniocular and more common in middle aged women. Progressive iris atrophy was the most common clinical variant. ICE syndrome was associated with glaucoma in over 70% of the eyes and half of the eyes had corneal edema.
[Mh] MeSH terms primary: Glaucoma/diagnosis
Iridocorneal Endothelial Syndrome/diagnosis
[Mh] MeSH terms secundary: Adult
Corneal Edema/diagnosis
Corneal Edema/etiology
Corneal Edema/therapy
Corneal Transplantation
Female
Follow-Up Studies
Glaucoma/etiology
Humans
India
Intraocular Pressure
Iridocorneal Endothelial Syndrome/complications
Iris/physiopathology
Male
Middle Aged
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170901
[Lr] Last revision date:170901
[Js] Journal subset:IM
[Da] Date of entry for processing:170311
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171884

  7 / 204 MEDLINE  
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[PMID]: 27977477
[Au] Autor:Mogil RS; Lee JM; Tirsi A; Tello C; Park SC
[Ad] Address:*Department of Ophthalmology, Manhattan Eye, Ear & Throat Hospital †Department of Ophthalmology, Hofstra Northwell School of Medicine, Hempstead, NY.
[Ti] Title:Iridocorneal Endothelial Syndrome Presenting With Large Diurnal Intraocular Pressure Fluctuation.
[So] Source:J Glaucoma;26(2):e99-e100, 2017 Feb.
[Is] ISSN:1536-481X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE OF THE STUDY: The purpose of the study was to report a case of iridocorneal endothelial syndrome with an initial presentation of a large diurnal fluctuation of intraocular pressure (IOP) which peaked early in the morning. METHODS: A 31-year-old white man had transient blurry vision oculus sinister (OS) upon awakening in the morning for the past 2 months. The blurry vision improved within 1 to 2 hours. Clinical examination, diurnal IOP measurements, and specular microscopy were performed to investigate the cause of his transient blurry vision. RESULTS: At 6 AM, IOP OS was 38 mm Hg with corneal edema and visual acuity of 20/30. At 8 AM, IOP OS decreased to 25 mm Hg with clear cornea and visual acuity of 20/20. Diurnal IOP measurements revealed a large fluctuation OS (18 mm Hg). Specular microscopy revealed pleomorphism, polymegathism, light peripheral borders and light/dark reversal of the corneal endothelium OS. IOP oculus dexter remained within normal limits with clear cornea and stable visual acuity throughout the diurnal measurements. CONCLUSIONS: In patients with consistent daily episodes of transient blurry vision, clinicians should suspect a large diurnal IOP fluctuation with high peak IOP. If symptoms and signs are unilateral, iridocorneal endothelial syndrome should be included in the differential diagnosis and corneal specular microscopy should be obtained.
[Mh] MeSH terms primary: Circadian Rhythm/physiology
Intraocular Pressure/physiology
Iridocorneal Endothelial Syndrome/diagnosis
Ocular Hypertension/diagnosis
Vision Disorders/diagnosis
[Mh] MeSH terms secundary: Adult
Gonioscopy
Humans
Iridocorneal Endothelial Syndrome/physiopathology
Male
Ocular Hypertension/physiopathology
Tomography, Optical Coherence
Tonometry, Ocular
Visual Acuity/physiology
Visual Field Tests
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170811
[Lr] Last revision date:170811
[Js] Journal subset:IM
[Da] Date of entry for processing:161216
[St] Status:MEDLINE
[do] DOI:10.1097/IJG.0000000000000607

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[PMID]: 27841796
[Au] Autor:Hohberger B; Welge-Lüen UC; Lämmer R
[Ad] Address:Department of Ophthalmology and Eye Clinic, Universitätsklinikum Erlangen, Friedrich-Alexander University, Erlangen-Nürnberg (FAU), Erlangen, Germany.
[Ti] Title:ICE-Syndrome: A Case Report of Implantation of a Microbypass Xen Gel Stent After DMEK Transplantation.
[So] Source:J Glaucoma;26(2):e103-e104, 2017 Feb.
[Is] ISSN:1536-481X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Treatment of glaucoma eyes with iridocorneal endothelial syndrome is complex. Minimally invasive glaucoma surgery, such as one that implements a novel, microinvasive device, known as Xen gel stents, has shown promise in surgical glaucoma treatment and offers a new therapeutic option. METHODS: This is a case report. RESULTS: A successful implantation of Xen45 gel stent in a woman with secondary glaucoma due to unilateral iridocorneal endothelial syndrome after descement membrane endothelial keratoplasty operation, and the follow-up are presented. CONCLUSIONS: Implantation of Xen gel stents may be a promising option for minimally invasive glaucoma surgery in difficult situations, as low adverse effects, good postsurgery visual acuity and sufficient regulation of intraocular pressure can be seen.
[Mh] MeSH terms primary: Descemet Stripping Endothelial Keratoplasty
Glaucoma/surgery
Iridocorneal Endothelial Syndrome/surgery
Prosthesis Implantation
Stents
[Mh] MeSH terms secundary: Female
Follow-Up Studies
Glaucoma/etiology
Glaucoma/physiopathology
Humans
Intraocular Pressure/physiology
Iridocorneal Endothelial Syndrome/complications
Iridocorneal Endothelial Syndrome/physiopathology
Middle Aged
Postoperative Complications
Retrospective Studies
Tonometry, Ocular
Visual Acuity/physiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170811
[Lr] Last revision date:170811
[Js] Journal subset:IM
[Da] Date of entry for processing:161115
[St] Status:MEDLINE
[do] DOI:10.1097/IJG.0000000000000584

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[PMID]: 27495952
[Au] Autor:Imamoglu S; Sevim MS; Yildiz HE; Vural ET; Bardak H; Bardak Y
[Ad] Address:Haydarpasa Numune Training and Research Hospital, Tibbiye Cad. No: 40, 34668, Üsküdar/Istanbul, Turkey. ophserhat@hotmail.com.
[Ti] Title:Surgical outcomes of patients with iridocorneal endothelial syndrome: a case series.
[So] Source:Int Ophthalmol;37(3):607-613, 2017 Jun.
[Is] ISSN:1573-2630
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The purpose of this study is to report the intermediate-term surgical outcomes of patients with iridocorneal endothelial syndrome-related glaucoma. The medical records of four patients (five eyes) surgery (Ahmed glaucoma valve implantation surgery and EX-PRESS mini shunt) were retrospectively reviewed. Median follow-up after glaucoma surgery was 24 (15-36) months. The preoperative intraocular pressure was significantly reduced from a median of 33 (22.5-36) mmHg on a median of 4 (4-5) glaucoma medications to a median of 12 (10.5-14.5) mmHg on a median of 2 (0-2) medications at last follow-up after surgery (p = 0.043 for IOP and p = 0.042 for glaucoma medications). Median preoperative visual acuity [0.016 (0.008-0.1)] did not change significantly when compared to median visual acuity at last follow-up [0.016 (0.004-0.5)] (p = 0.59). Intraocular pressure control in patients with iridocorneal endothelial syndrome is challenging and may require multiple operations and revisions. Some modifications during glaucoma drainage implant surgery and use of EX-PRESS mini shunt in certain cases could offer an advantage in these patients.
[Mh] MeSH terms primary: Glaucoma Drainage Implants
Glaucoma/surgery
Intraocular Pressure
Iridocorneal Endothelial Syndrome/surgery
Visual Acuity
[Mh] MeSH terms secundary: Adult
Aged
Female
Follow-Up Studies
Glaucoma/etiology
Glaucoma/physiopathology
Humans
Iridocorneal Endothelial Syndrome/complications
Iridocorneal Endothelial Syndrome/diagnosis
Male
Middle Aged
Retrospective Studies
Tonometry, Ocular
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171020
[Lr] Last revision date:171020
[Js] Journal subset:IM
[Da] Date of entry for processing:160807
[St] Status:MEDLINE
[do] DOI:10.1007/s10792-016-0317-1

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[PMID]: 27929720
[Au] Autor:Rao A; Padhy D; Sarangi S; Das G
[Ad] Address:a Glaucoma Service , LV Prasad Eye Institute , Bhubaneswar , Odisha , India.
[Ti] Title:Unclassified Axenfeld-Rieger Syndrome: A CASE SERIES and Review of Literature.
[So] Source:Semin Ophthalmol;:1-8, 2016 Dec 08.
[Is] ISSN:1744-5205
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: To report anterior segment features in unclassified anterior segment dysgenesis with overlapping features of Axenfeld-Rieger syndrome and other developmental anomalies. METHODS: This retrospective study included those with atypical or overlapping features in one or both eyes, which were identified as unclassified ASD. Typical ARS was defined as the presence of posterior embryotoxon with or without iris changes like stromal hypoplasia, corectopia, polycoria, or ectropion uvea with or without systemic features. Cases of ARS with overlapping features with other ASD, like aniridia (complete or incomplete absence of iris), iridocorneal endothelial (ICE) syndrome (beaten metal appearance of corneal endothelium), Peters anomaly, isolated trabeculodysgenesis (evidenced by Haab's striae, buphthalmos, and epiphora) in one or both eyes with other typical ARS features in the same or other eye were included and screened. RESULTS: Of 56 cases of ARS seen over 10 years, a total of 17 eyes of 11 cases (M:F=9:2, unilateral n=3) with unclassified ASD were identified with a median age of patients of 28.45±17.75 years (range 6-30 years). All cases of unclassified ASD had the presence of focal atypical strands of non-progressive anterior synechiae extending from the iris mid-periphery to the cornea with no attachments to the Schwalbe's line in any case. Adjacent keratic precipitates or pigment were present in three eyes with focal beaten metal appearance in one eye. Three patients developed repeated episodes of anterior uveitis in one eye with stromal involvement seen in all cases, which responded to antiviral therapy. CONCLUSIONS: Atypical features like focal strands with differential corneal involvement and onset of viral uveitis in unclassified ARS suggest a possible viral etiology during different periods of eye development.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1612
[Cu] Class update date: 171026
[Lr] Last revision date:171026
[St] Status:Publisher
[do] DOI:10.1080/08820538.2016.1208767


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