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[PMID]: 28465249
[Au] Autor:Pichi F; Sarraf D; Arepalli S; Lowder CY; Cunningham ET; Neri P; Albini TA; Gupta V; Baynes K; Srivastava SK
[Ad] Address:Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: ilmiticopicchio@gmail.com.
[Ti] Title:The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases.
[So] Source:Prog Retin Eye Res;59:178-201, 2017 Jul.
[Is] ISSN:1873-1635
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Since its introduction in the early 1990s, optical coherence tomography (OCT) has evolved in resolution and technological advances, and in recent years its initial application of assessing the morphology of a tissue has been implemented by the study of its functional blood flow, through optical coherence tomography angiography (OCTA). This novel technique details capillary networks by comparing the amount of light returned from static and moving targets without the need for intravenous dye administration. While this imaging modality has been used for various ocular conditions, the application OCTA to uveitis conditions remains sparse. This review aims to establish the basis of OCTA and its current application to ocular inflammatory disorders, with an emphasis on monitoring progression and response to treatment, as well as predicting visual complications. In particular, this review explores the use of OCTA in iris vessel dilation seen in various forms of iritis, as a predictive factor for further episodes of inflammation. OCTA can also depict ischemia in the deep plexus layers of the retina and identify true choroicapillaris ischemia in cases of placoid diseases or masking of the indocyanine green dye, as in multiple evanescent white dot syndrome. In addition, OCTA can depict neovascularization in granulomatous disease of the retina or choroid not previously depicted with previous imaging methods. While OCTA provides several advancements in the imaging, management and prognosis of uveitis diseases, we emphasize that further studies are required to fully understand its application to these conditions.
[Mh] MeSH terms primary: Chorioretinitis/diagnosis
Fluorescein Angiography/methods
Retinal Vessels/pathology
Tomography, Optical Coherence/methods
Uveitis/diagnosis
[Mh] MeSH terms secundary: Fundus Oculi
Humans
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180202
[Lr] Last revision date:180202
[Js] Journal subset:IM
[Da] Date of entry for processing:170504
[St] Status:MEDLINE

  2 / 1564 MEDLINE  
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[PMID]: 29271812
[Au] Autor:Bhakta AS; Fortun J; Thomas J; Greer A; Kishor K; Maharaj A
[Ad] Address:Bascom Palmer Eye Institute, University of Miami, Palm Beach.
[Ti] Title:Visually Significant Cystoid Macula Edema After Glaucoma Drainage Implant Surgery.
[So] Source:J Glaucoma;27(2):184-188, 2018 Feb.
[Is] ISSN:1536-481X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: This study examines the incidence of visually significant cystoid macular edema (CME) after glaucoma drainage implant (GDI) surgery and analyses risk factors associated with developing CME and prognosis with treatment. MATERIALS AND METHODS: In total, 185 eyes from 185 glaucoma patients (mean age, 72.46±13.94 y) who underwent GDI surgery at a tertiary eye institute were recruited. Patients were classified based on the presence (CME) or absence (No-CME) of CME. Pre-GDI and post-GDI best-corrected visual acuity, number of intraocular pressure (IOP)-lowering medications, IOP, standard automated perimetry and post-GDI complications, were recorded and compared between the 2 groups. Optical coherence tomography (OCT) was used to quantify retinal thickness and monitor CME. RESULTS: In total, 41 (22.2%) eyes developed visually significant CME after GDI surgery. Patients with CME had a higher incidence of pre-GDI nonsteroidal anti-inflammatory drug (P<0.01) use and higher number of prior glaucoma surgeries (P<0.01). CME patients had a higher (P<0.01) incidence of iritis, epiretinal membrane, and hypotony. CME eyes responded well to steroids, with resolving macular edema (458.4±151.9 vs. 322.0±92.0 µm, P<0.01) and improving visual acuity (0.73±0.48 vs. 0.56±0.56 logarithm of minimum angle of resolution, P<0.01). Both CME and non-CME groups had equivalent lowering of IOP and post-GDI glaucoma medications; with no significant elevation in IOP in the steroid-treated CME group. CONCLUSIONS: Post-GDI surgery visually significant CME rates are potentially higher in a real hospital scenario compared with controlled clinical trials. With diligent treatment, CME resolves effectively restoring visual acuity and central macular thickness.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180131
[Lr] Last revision date:180131
[St] Status:In-Data-Review
[do] DOI:10.1097/IJG.0000000000000855

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[PMID]: 29266031
[Au] Autor:Kaufman AR; Myers EM; Moster ML; Stanley J; Kline LB; Golnik KC
[Ad] Address:Boston University School of Medicine (ARK), Boston, Massachusetts; Department of Ophthalmology (EMM, KCG), University of Cincinnati, Cincinnati Eye Institute, Cincinnati, Ohio; Neuro-Ophthalmology Service (MLM), Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania; and Department of Ophthalmology (JS, LBK), University of Alabama School of Medicine, Birmingham, Alabama.
[Ti] Title:Herpes Zoster Optic Neuropathy.
[So] Source:J Neuroophthalmol;, 2017 Dec 20.
[Is] ISSN:1536-5166
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Herpes zoster optic neuropathy (HZON) is a rare manifestation of herpes zoster ophthalmicus (HZO). The aim of our study was to better characterize the clinical features, therapeutic choices, and visual outcomes in HZON. METHODS: A retrospective chart review was performed at multiple academic eye centers with the inclusion criteria of all eyes presenting with optic neuropathy within 1 month of cutaneous zoster of the ipsilateral trigeminal dermatome. Data were collected regarding presenting features, treatment regimen, and visual acuity outcomes. RESULTS: Six patients meeting the HZON inclusion criteria were identified. Mean follow-up was 2.75 months (range 0.5-4 months). Herpes zoster optic neuropathy developed at a mean of 14.1 days after initial rash (range 6-30 days). Optic neuropathy was anterior in 2 eyes and retrobulbar in 4 eyes. Other manifestations of HZO included keratoconjunctivitis (3 eyes) and iritis (4 eyes). All patients were treated with systemic antiviral therapy in addition to topical and/or systemic corticosteroids. At the last follow-up, visual acuity in 3 eyes had improved relative to presentation, 2 eyes had worsened, and 1 eye remained the same. The 2 eyes that did not receive systemic corticosteroids had the best observed final visual acuity. CONCLUSION: Herpes zoster optic neuropathy is an unusual but distinctive complication of HZO. Visual recovery after HZON is variable. Identification of an optimal treatment regiment for HZON could not be identified from our patient cohort. Systemic antiviral agents are a component of HZON treatment regimens. Efficacy of systemic corticosteroids for HZON remains unclear and should be considered on a case-by-case basis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171221
[Lr] Last revision date:171221
[St] Status:Publisher
[do] DOI:10.1097/WNO.0000000000000607

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[PMID]: 29210535
[Au] Autor:Watkinson S; Seewoodhary R
[Ad] Address:College of Nursing, Midwifery and Healthcare, University of West London, West London campus, Brentford, Middlesex, England.
[Ti] Title:Assessment, care and management of patients with red eye.
[So] Source:Nurs Stand;32(15):43-50, 2017 Dec 06.
[Is] ISSN:2047-9018
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Red eye is a common ocular presentation in primary care, and there are several challenges that healthcare practitioners may encounter when caring for such patients. The main ocular conditions that can give rise to red eye are: primary acute angle closure glaucoma, acute iritis, dry eye, blepharitis and conjunctivitis. Red eye can be classified as sight-threatening or non-sight-threatening. Many patients presenting with painless red eye and normal vision usually recover well. However, when red eye is associated with pain, photophobia, watering and blurred vision, it is potentially sight-threatening and must be addressed urgently. Therefore, it is vital for healthcare practitioners to be able to undertake a careful assessment of the patient and make an accurate diagnosis early. This article provides an overview of the common causes of red eye encountered in general practice or an eye clinic. It discusses the nurse's role in the care and management of patients with red eye, with reference to patient assessment, the skills required to make an accurate diagnosis, treatment and health promotion.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171206
[Lr] Last revision date:171206
[St] Status:In-Data-Review
[do] DOI:10.7748/ns.2017.e10902

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[PMID]: 29141390
[Au] Autor:Lin KJ; Chen J; Lin W; Lin XD; Zhou YM; Zheng LD; Tong Y
[Ad] Address:Fuzhou SouthEast Eye Hospital, Fuzhou 350001, China.
[Ti] Title:[The clinical analysis of corneal interface fluid syndrome after Laser lamellar corneal refractive surgery].
[So] Source:Zhonghua Yan Ke Za Zhi;53(11):847-854, 2017 Nov 11.
[Is] ISSN:0412-4081
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To analysis, the clinical characteristics, refractive changes, and clinical treatment of interface fluid syndrome after laser lamellar corneal refractive surgery. During Dec. 2010 to Apr. 2016. In total 6 cases(9 eyes), 3 cases were bilateral, 3 cases were unilateral. Five patients were male and 1 was female. The age of the patients ranged from 20 to 29 years was (24.83±4.02) years. Six cases(9 eyes)of IFS were diagnosed at our hospital. The history and complete ophthalmic examination that include Slit-lamp examination, Slit-lamp photography, refraction, corneal thickness measurement, corneal endothelial cell counting, IOP, anterior segment OCT(AS-OCT), exams were recorded. Post-lasik Primary open angle glaucoma was 2 eyes in 1 patient. 1 patient(1 eye)was Posner-Schlossmann Syndrome and 1 patient(1 eye)was iritis after femtosecond laser. Post-small incision lenticule extraction by steroid drops induced elevated IOP were 5 eyes in 3 patients. Slit-lamp exam indicated edematous corneal flap or cap, lamellar haze, interface fluids accumulation. AS-OCT showed obvious interface dark area. The corneal flap or cap thickening and wrinkles, IOP change, diopter myopic shift, Corneal thickening. IFS is a rare but serious complication after Laser lamellar corneal refractive surgery. The main causes are high intraocular pressure and/or dysfunction of corneal endothelium. For patients with high IOP after laser lamellar corneal refractive surgery, follow up should be observed closely. accurate diagnosis by OCT and corneal endothelial cell counting. Early diagnosis, accurate treatment, its prognosis is good. .
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0412-4081.2017.11.009

  6 / 1564 MEDLINE  
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[PMID]: 29028372
[Au] Autor:Razeghinejad MR
[Ad] Address:a Glaucoma Service , Wills Eye Institute , Philadelphia , Pennsylvania , USA.
[Ti] Title:The Effect of Latanaprost on Intraocular Inflammation and Macular Edema.
[So] Source:Ocul Immunol Inflamm;:1-8, 2017 Oct 13.
[Is] ISSN:1744-5078
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:There is debate concerning whether the use of Latanoprost in early postoperative period of cataract surgery and in glaucoma patients with uveitis as it may aggravate the inflammation and results in macular edema (ME), because of blood-ocular barrier disruption. However, there is no solid evidence for disruption of blood-ocular barrier with Latanoprost and aggravation of uveitis or ME formation. Similar to pseudophakic ME, the imaging ME in cases claimed to be secondary to Latanoprost is greater than clinical ME, happens mostly in complicated surgeries, and the vast majority resolve within weeks to months with using a non-steroidal anti-inflammatory drug. The current literature suggests that Latanoprost can be used in patients with uveitis and early after cataract surgery with or without concomitant topical non-steroidal anti-inflammatory drugs that are currently used by many ophthalmologists as a preventive measure for ME even in non-glaucoma uncomplicated cataract surgeries.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171026
[Lr] Last revision date:171026
[St] Status:Publisher
[do] DOI:10.1080/09273948.2017.1372485

  7 / 1564 MEDLINE  
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[PMID]: 28942431
[Au] Autor:Krishna U; Ajanaku D; Denniston AK; Gkika T
[Ad] Address:Department of Ophthalmology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.
[Ti] Title:Uveitis: a sight-threatening disease which can impact all systems.
[So] Source:Postgrad Med J;, 2017 Sep 23.
[Is] ISSN:1469-0756
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Uveitis describes a group of conditions characterised by intraocular inflammation. The term uveitis technically describes inflammation of the uvea which comprises the iris, ciliary body and choroid, however now encompasses inflammation of adjacent intraocular structures such as the retina, vitreous and optic nerve. Uveitis is a significant cause of blindness worldwide, but its impact is generally underappreciated due to a lack of awareness and understanding of the condition among the public and most non-ophthalmic healthcare professionals. In this review, we provide an introduction to uveitis for the non-specialist, outlining the clinical presentations that should raise the suspicion of the disease, the signs that should be looked for and a framework in which to understand the condition. We show how a logical approach to classifying uveitis by aetiology and anatomical focus of disease provides the basis for treatment strategies (drug and route of administration) and clinical presentation and prognosis. We also show why understanding uveitis is helpful to clinicians working in almost every speciality due to the wide-ranging associations with systemic disease.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1709
[Cu] Class update date: 170924
[Lr] Last revision date:170924
[St] Status:Publisher

  8 / 1564 MEDLINE  
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[PMID]: 28894356
[Au] Autor:Schallhorn SC; Schallhorn JM; Pelouskova M; Venter JA; Hettinger KA; Hannan SJ; Teenan D
[Ad] Address:Department of Ophthalmology, University of California, San Francisco, CA, USA.
[Ti] Title:Refractive lens exchange in younger and older presbyopes: comparison of complication rates, 3 months clinical and patient-reported outcomes.
[So] Source:Clin Ophthalmol;11:1569-1581, 2017.
[Is] ISSN:1177-5467
[Cp] Country of publication:New Zealand
[La] Language:eng
[Ab] Abstract:PURPOSE: To compare refractive and visual outcomes, patient satisfaction, and complication rates among different age categories of patients who underwent refractive lens exchange (RLE). METHODS: A stratified, simple random sample of patients matched on preoperative sphere and cylinder was selected for four age categories: 45-49 years (group A), 50-54 years (group B), 55-59 years (group C), and 60-65 years (group D). Each group contained 320 patients. All patients underwent RLE with a multifocal intraocular lens at least in one eye. Three months postoperative refractive/visual and patient-reported outcomes are presented. RESULTS: The percentage of patients that achieved binocular uncorrected distance visual acuity 20/20 or better was 91.6% (group A), 93.8% (group B), 91.6% (group C), 88.8% (group D), =0.16. Binocularly, 80.0% of patients in group A, 84.7% in group B, 78.9% in group C, and 77.8% in group D achieved 20/30 or better uncorrected near visual acuity ( =0.13). The proportion of eyes within 0.50 D of emmetropia was 84.4% in group A, 86.8% in group B, 85.7% in group C, and 85.8% in group D ( =0.67). There was no statistically significant difference in postoperative satisfaction, visual phenomena, dry eye symptoms, distance or near vision activities. Apart from higher rate of iritis in the age group 50-55 years, there was no statistically significant difference in postoperative complication rates. CONCLUSION: RLE can be safely performed in younger as well as older presbyopes. No significant difference was found in clinical or patient-reported outcomes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170914
[Lr] Last revision date:170914
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.2147/OPTH.S143201

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[PMID]: 28781308
[Au] Autor:Okuma H; Hashimoto K; Wang X; Ohkiba N; Murooka N; Akizuki N; Inazawa T; Ogawa Y
[Ad] Address:Department of Endocrinology and Metabolism, Kashiwa City Kashiwa Hospital, Japan.
[Ti] Title:Systemic Sarcoidosis with Thyroid Involvement.
[So] Source:Intern Med;56(16):2181-2186, 2017 Aug 15.
[Is] ISSN:1349-7235
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:A 66-year-old woman, who was diagnosed with iritis, visited our hospital due to general malaise. A blood analysis revealed hypercalcemia. Computed tomography revealed mediastinal and hilar lymph node hyperplasia. Moreover, Gallium scintigraphy demonstrated strong accumulation in the lesions, suggesting sarcoidosis. A core needle biopsy (CNB) of the hypoechoic areas of the thyroid was performed because the patient refused to undergo a bronchoscopic examination. The scattering of slightly acidophilic epithelioid cell granulomas was observed in the pathological examination of the biopsy specimen. Based on this finding, the patient was diagnosed with sarcoidosis. Although sarcoidosis rarely involves the thyroid gland, in the present case, thyroid CNB was an alternative diagnostic method that allowed a pathological diagnosis to be obtained.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170915
[Lr] Last revision date:170915
[St] Status:In-Process
[do] DOI:10.2169/internalmedicine.8324-16

  10 / 1564 MEDLINE  
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[PMID]: 28705843
[Au] Autor:Dawson ET; Brown DA; Rabinstein AA
[Ad] Address:Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
[Ti] Title:Headache, TIA and subarachnoid haemorrhage: dissecting an unusual cause for stroke-like symptoms.
[So] Source:BMJ Case Rep;2017, 2017 Jul 13.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:We present a case of supraclinoid internal carotid artery dissection. Eleven months prior, the patient developed isolated periorbital pain and was diagnosed with giant-cell arteritis with iritis. The patient experienced recurrent spells concerning for transient ischaemic attacks and was transferred to our institution for endovascular intervention after head CT revealed an embolic infarct with a 'dense middle cerebral artery sign.' Digital subtraction angiography was negative for occlusion, instead demonstrating luminal stenosis and poststenotic dilatation. He subsequently experienced acute neurological decline secondary to massive subarachnoid haemorrhage. Non-invasive vascular imaging revealed an intimal flap and a pseudoaneurysm at the site of luminal stenosis, confirming our suspicion for intracranial carotid artery dissection. Given the moribund clinical state, the family opted to withdraw care, and he quickly expired.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170714
[Lr] Last revision date:170714
[St] Status:In-Process


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