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[PMID]: 29524889
[Au] Autor:van der Grift B; Osté L; Schot P; Kratz A; van Popta E; Wassen M; Griffioen J
[Ad] Address:Deltares, P.O. Box 85467, 3508 AL Utrecht, The Netherlands. Electronic address: bas.vandergrift@deltares.nl.
[Ti] Title:Forms of phosphorus in suspended particulate matter in agriculture-dominated lowland catchments: Iron as phosphorus carrier.
[So] Source:Sci Total Environ;631-632:115-129, 2018 Mar 07.
[Is] ISSN:1879-1026
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The fate and environmental effects of phosphorus (P) in natural waters depend on its chemical forms. The particulate P (PP) concentration is dominant over the dissolved P concentration in agriculture-dominated headwaters in the Netherlands. Routine water quality monitoring programmes do not include the chemical fractionation of PP. To quantify the chemical forms of PP under various conditions in six agriculture-dominated lowland catchments in the Netherlands, a sequential chemical extraction method was applied to suspended particulate matter (SPM) samples collected by centrifugation or filtration. Centrifuge samples had lower values for the sum of the PP fractions compared with the filtration samples due to lower contents from PP fractions other than the Fe-P pool. With an average value of 8.8mgg , internationally high P contents of the SPM were found. Ferric iron-bound P was the most important PP fraction in SPM samples (38-95%; median 74%), followed by organic P (2-38%; median 15%). Exchangeable P ranged from 0.2 to 27%, with a median of 4.4%, Ca-P ranged from 0.1 to 11% with a median of 3.9% and detrital P was present in only a small fraction (0-6%; median 1.1%). Ferric iron-bound P was the dominant PP pool throughout the entire range of watercourses (from headwater ditches to catchment outlets) and in samples taken during winter months as well as those taken during summer months. Furthermore, the PP fraction distribution did not change markedly when flow conditions were altered from low to high discharge. The dominance of the Fe-P pool denotes the presence of Fe(III) precipitates in SPM that originate from exfiltration of anoxic Fe-bearing groundwater. These Fe(III) precipitates are a major fraction of the total SPM concentration (4 to 67% as Fe(OH) ; median 18%). Although not measured directly, our results suggest that formation of authigenic Fe(III) precipitates causes a rapid transformation of dissolved P in groundwater to PP in surface water. We advise including sequential chemical extraction of SPM monitoring programmes because the composition of particles is critical for P bioavailability, which is a key driving factor for eutrophication.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 245920 MEDLINE  
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[PMID]: 29524802
[Au] Autor:Ferreira PAA; Marchezan C; Ceretta CA; Tarouco CP; Lourenzi CR; Silva LS; Soriani HH; Nicoloso FT; Cesco S; Mimmo T; Brunetto G
[Ad] Address:Department of Soil Science, Federal University of Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil.
[Ti] Title:Soil amendment as a strategy for the growth of young vines when replanting vineyards in soils with high copper content.
[So] Source:Plant Physiol Biochem;126:152-162, 2018 Mar 02.
[Is] ISSN:1873-2690
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Soil contamination with copper (Cu)-based agrochemicals used in vineyards for pest control is a growing problem. In this context, the application of soil amendment to limit Cu toxicity, especially for young plants after the replanting of vineyards, has been a concern for winemakers. Therefore, the aim of this study was to evaluate how different amendments can contribute to the decrease in Cu availability in areas vocated to viticulture. Furthermore, the aim was to evaluate to the effect of Cu on the biochemical and physiological changes in the development of the young vine plants, both at the shoot and the root level. Vine plants were grown in a greenhouse using a Typic Hapludalf soil characterized by 87.5 mg of Cu kg (control). Three different amendments were applied to the soil: limestone (3 Mg ha ), calcium silicate (3 Mg ha ) and vermicompost (30 g of C kg ). The amendment with vermicompost and calcium silicate caused a significant alkalization of the soil solution. Moreover, specifically for the treatment with vermicompost, the levels of Cu in the soil solution were consistently diminished with a clear benefit for plants (+89% biomass accumulation at the shoot level). In addition, this soil amendment led to a higher photosynthetic rate, lower superoxide dismutase (SOD, EC 1.15.1.1) and guaiacol peroxidase (POD, EC 1.11.1.7) activity and a higher percentage of fine roots with diameter between 0 < L ≥ 0.2 mm (particularly active in water and nutrient acquisition). In conclusion, results showed that vermicompost effectively reduced Cu phytotoxicityin young vines grown in soils with high Cu contents. Furthermore, this amendment might be an asset in enhancing the availability of other important micronutrients such as iron.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524748
[Au] Autor:Pelosi C; Capobianco G; Agresti G; Bonifazi G; Morresi F; Rossi S; Santamaria U; Serranti S
[Ad] Address:Department of Economics, Engineering, Society and Business Organization, Laboratory of Diagnostics and Materials Science, University of Tuscia, Largo dell'Università, 01100 Viterbo, Italy. Electronic address: pelosi@unitus.it.
[Ti] Title:A methodological approach to study the stability of selected watercolours for painting reintegration, through reflectance spectrophotometry, Fourier transform infrared spectroscopy and hyperspectral imaging.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;198:92-106, 2018 Mar 05.
[Is] ISSN:1873-3557
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The aim of this work is to investigate the stability to simulated solar radiation of some paintings samples through a new methodological approach adopting non-invasive spectroscopic techniques. In particular, commercial watercolours and iron oxide based pigments were used, these last ones being prepared for the experimental by gum Arabic in order to propose a possible substitute for traditional reintegration materials. Reflectance spectrophotometry in the visible range and Hyperspectral Imaging in the short wave infrared were chosen as non-invasive techniques for evaluation the stability to irradiation of the chosen pigments. These were studied before and after artificial ageing procedure performed in Solar Box chamber under controlled conditions. Data were treated and elaborated in order to evaluate the sensitivity of the chosen techniques in identifying the variations on paint layers, induced by photo-degradation, before they could be observed by eye. Furthermore a supervised classification method for monitoring the painted surface changes adopting a multivariate approach was successfully applied.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 245920 MEDLINE  
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[PMID]: 29524595
[Au] Autor:Alaqzam TS; Stanley AC; Simpson PM; Flood VH; Menon S
[Ad] Address:Department of Pediatrics, Division of Adolescent Medicine, Medical College of Wisconsin. Electronic address: talaqzam@mcw.edu.
[Ti] Title:Treatment Modalities in Adolescents Who present With Heavy Menstrual Bleeding.
[So] Source:J Pediatr Adolesc Gynecol;, 2018 Mar 07.
[Is] ISSN:1873-4332
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:STUDY OBJECTIVE: This study sought to determine the relationship of bleeding disorders to iron deficiency anemia. Additionally, this study was undertaken to examine all current treatment modalities used in a menorrhagia clinic with respect to heavy menstrual bleeding management to identify the most effective options for menstrual management in the setting of an underlying bleeding disorder. DESIGN, SETTING, PARTICIPANT, INTERVENTION, AND MAIN OUTCOME MEASURES: Retrospective chart review of adolescent <21 years with heavy menstrual bleeding attending a multidisciplinary hematology-adolescent gynecology clinic. Information included demographics, bleeding diathesis, hematologic parameters, treatment, and the diagnosis was extracted from each chart. Subjects were grouped into two categories based on the diagnosis of a bleeding disorder. Hemoglobin level, iron deficiency anemia, and need for transfusion were compared between a bleeding disorder and no bleeding disorder group. Subjects were grouped into categories depending on hormonal modality and treatment success of the groups were compared. RESULTS: 73 subjects tested for a bleeding disorder. Of the subjects completing testing, 34 (46%) were diagnosed with a bleeding disorders. 39 (54%) subjects had heavy menstrual bleeding due to other causes. There was no significant difference in hemoglobin between those with and without a bleeding disorder. Iron deficiency anemia was significantly higher in subjects without bleeding disorder. When comparing hormone therapy success, the levonorgestrel IUD (LNG-IUD) (89%) had the highest rate of menstrual suppression followed by norethindrone acetate 5-10mg/day (83%), and the transdermal patch (80%). All subjects using both tranexamic acid and hormonal therapy had 100% achievement of menstrual suppression. CONCLUSION: A high frequency of bleeding disorder was found in those tested. Subjects with a bleeding disorder were less likely to present with severe anemia requiring blood transfusion and less likely to have iron deficiency anemia. While combined oral contraceptives were commonly used clinically for menstrual suppression, they were not found to be the most effective option.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  5 / 245920 MEDLINE  
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[PMID]: 29524546
[Au] Autor:Abdollahi S; Rasooli I; Gargari SLM
[Ad] Address:Department of Biology, Shahed University, Tehran-Qom Express Way, Tehran, Iran.
[Ti] Title:An in silico structural and physicochemical characterization of TonB-dependent copper receptor in A. baumannii.
[So] Source:Microb Pathog;, 2018 Mar 07.
[Is] ISSN:1096-1208
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Acinetobacter baumannii is an opportunistic multidrug resistant pathogen. TonB-dependent copper receptor is an outer membrane protein and has a role in binding of A. baumannii to host cell via attachment to fibronectin. Moreover, it is highly expressed in biofilm community. In this study the properties of copper receptor were analyzed in silico and its vaccine potential was investigated. TonB-dependent copper and iron receptor domains plus one plug domain at N-terminal were determined by domain analysis. Topology modeling showed 22 ß-strands, 11 loops and 10 periplasmic turns. Interaction of this protein with TonB2 energy transducer was also indicated. Beside the antigenicity, this protein could take part in bacterial virulence. The more preferable 3D structure was selected amongst all 26 predicted structures, refined and used in prediction of ligand binding site and conformational epitope. The results of B and T-cell epitope mapping indicated 8 potential areas in the protein sequence and structure that seems to be able to stimulate both humoral and cellular immune responses. Based on the alignment result, this protein and all selected epitopes are extremely conserved among A. baumannii strains which can be tested as sub unit vaccine by in vivo studies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  6 / 245920 MEDLINE  
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[PMID]: 29524511
[Au] Autor:Chi CB; Tang Y; Zhang J; Dai YN; Abdalla M; Chen Y; Zhou CZ
[Ad] Address:School of Life Sciences and Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China; Key Laboratory of Structural Biology, Chinese Academy of Science, Hefei, Anhui, 230027, People's Republic of
[Ti] Title:Structural and biochemical insights into the multiple functions of yeast Grx3.
[So] Source:J Mol Biol;, 2018 Mar 07.
[Is] ISSN:1089-8638
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The yeast Sacchromyces cerevisiae monothiol glutaredoxin Grx3 plays a key role in cellular defense against oxidative stress and more importantly, cooperates with BolA-like iron repressor of activation protein Fra2 to regulate the localization of the iron-sensing transcription factor Aft2. The interplay among Grx3, Fra2 and Aft2 responsible for the regulation of iron homeostasis has not been clearly described. Here we solved the crystal structures of the Trx domain (Grx3 ) and Grx domain (Grx3 ) of Grx3 in addition to the solution structure of Fra2. Structural analyses and activity assays indicated that the Trx domain also contributes to the glutathione S-transferase activity of Grx3, via an inter-domain disulfide bond between Cys37 and Cys176. NMR titration and pull-down assays combined with surface plasmon resonance experiments revealed that Fra2 could forms a noncovalent heterodimer with Grx3 via an interface between the helix-turn-helix motif of Fra2 and the C-terminal segment of Grx3 , different from the previously identified covalent heterodimer mediated by Fe-S cluster. Comparative affinity assays indicated that the interaction between Fra2 and Aft2 is much stronger than that between Grx3 and Aft2, or Aft2 towards its target DNA. These structural and biochemical analyses enabled us to propose a model how Grx3 executes multiple functions to coordinate the regulation of Aft2-controlled iron metabolism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  7 / 245920 MEDLINE  
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[PMID]: 29520342
[Au] Autor:Schwiesow L; Mettert E; Wei Y; Miller HK; Herrera NG; Balderas D; Kiley PJ; Auerbuch V
[Ad] Address:Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, United States.
[Ti] Title:Control of Heme Uptake Genes in in Response to Iron Sources.
[So] Source:Front Cell Infect Microbiol;8:47, 2018.
[Is] ISSN:2235-2988
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Despite the mammalian host actively sequestering iron to limit pathogenicity, heme (or hemin when oxidized) and hemoproteins serve as important sources of iron for many bloodborne pathogens. The HmuRSTUV hemin uptake system allows species to uptake and utilize hemin and hemoproteins as iron sources. HmuR is a TonB-dependent outer membrane receptor for hemin and hemoproteins. HmuTUV comprise a inner membrane ABC transporter that transports hemin and hemoproteins from the periplasmic space into the bacterial cytoplasm, where it is degraded by HmuS. Here we show that but not are expressed under iron replete conditions, whereas as well as are expressed under iron limiting conditions, suggesting complex transcriptional control. Indeed, expression of in the presence of inorganic iron, but not in the presence of hemin, requires the global regulator IscR acting from a promoter in the intergenic region between and . This effect of IscR appears to be direct by binding a site mapped by DNaseI footprinting. In contrast, expression of under iron limiting conditions requires derepression of the ferric uptake regulator Fur acting from the promoter, as Fur binding upstream of was demonstrated biochemically. Differential expression by both Fur and IscR would facilitate maximal hemin uptake and utilization when iron and heme availability is low while maintaining the capacity for periplasmic removal and cytosolic detoxification of heme under a wider variety of conditions. We also demonstrate that a Δ mutant has a survival defect when incubated in whole blood, in which iron is sequestered by heme-containing proteins. Surprisingly, this phenotype was independent of the Hmu system, the type III secretion system, complement, and the ability of to replicate intracellularly. These results suggest that IscR regulates multiple virulence factors important for survival and growth in mammalian tissues and reveal a surprising complexity of heme uptake expression and function under differing conditions of iron.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.3389/fcimb.2018.00047

  8 / 245920 MEDLINE  
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[PMID]: 29520140
[Au] Autor:Pan C; Liu Y; Zhou M; Wang W; Shi M; Xing M; Liao W
[Ad] Address:Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
[Ti] Title:Theranostic pH-sensitive nanoparticles for highly efficient targeted delivery of doxorubicin for breast tumor treatment.
[So] Source:Int J Nanomedicine;13:1119-1137, 2018.
[Is] ISSN:1178-2013
[Cp] Country of publication:New Zealand
[La] Language:eng
[Ab] Abstract:A multifunctional theranostic nanoplatform integrated with environmental responses has been developed rapidly over the past few years as a novel treatment strategy for several solid tumors. We synthesized pH-sensitive poly(ß-thiopropionate) nanoparticles with a supermagnetic core and folic acid (FA) conjugation (FA-doxorubicin-iron oxide nanoparticles [FA-DOX@ IONPs]) to deliver an antineoplastic drug, DOX, for the treatment of folate receptor (FR)-overexpressed breast cancer. In addition to an imaging function, the nanoparticles can release their payloads in response to an environment of pH 5, such as the acidic environment found in tumors. After chemical ( H nuclear magnetic resonance) and physical (morphology and super-magnetic) characterization, FA-DOX@IONPs were shown to demonstrate pH-dependent drug release profiles. Western blotting analysis revealed the expression of FRs in three breast cancer cell lines, MCF-7, BT549, and MD-MBA-231. The cell counting kit-8 assay and transmission electron microscopy showed that FA-DOX@IONPs had the strongest cytotoxicity against breast cancer cells, compared with free DOX and non-FR targeted nanoparticles (DOX@IONPs), and caused cellular apoptosis. The FA-DOX@IONP-mediated cellular uptake and intracellular internalization were clarified by fluorescence microscopy. FA-DOX@IONPs plus magnetic field treatment suppressed in vivo tumor growth in mice to a greater extent than either treatment alone; furthermore, the nanoparticles exerted no toxicity against healthy organs. Magnetic resonance imaging was successfully applied to monitor the nanoparticle accumulation. Our results suggest that theranostic pH-sensitive nanoparticles with dual targeting could enhance the available therapies for cancer.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.2147/IJN.S147464

  9 / 245920 MEDLINE  
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[PMID]: 29511567
[Au] Autor:Reinhart JM; Rose W; Panyard DJ; Newton MA; Liebenstein TK; Yee J; Trepanier LA
[Ad] Address:Department of Medical SciencesSchool of Veterinary MedicineUniversity of Wisconsin-MadisonMadisonWIUSA.
[Ti] Title:RNA expression profiling in sulfamethoxazole-treated patients with a range of in vitro lymphocyte cytotoxicity phenotypes.
[So] Source:Pharmacol Res Perspect;6(2):e00388, 2018 Apr.
[Is] ISSN:2052-1707
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The lymphocyte toxicity assay (LTA) is a proposed surrogate marker of sulfonamide antibiotic hypersensitivity. In the LTA, peripheral blood mononuclear cells (PBMCs) undergo apoptosis more readily in hypersensitive versus tolerant patients when exposed to drug-hydroxylamine metabolites in vitro. The purpose of this study was to identify key gene transcripts associated with increased cytotoxicity from sulfamethoxazole-hydroxylamine in human PBMCs in the LTA. The LTA was performed on PBMCs of 10 patients hypersensitive to trimethoprim-sulfamethoxazole (HS) and 10 drug-tolerant controls (TOL), using two cytotoxicity assays: YO-PRO (n = 20) and MTT (n = 12). mRNA expression profiles of PBMCs, enriched for CD8 T cells, were compared between HS and TOL patients. Transcript expression was interrogated for correlation with % cytotoxicity from YO-PRO and MTT assays. Correlated transcripts of interest were validated by qPCR. LTA results were not significantly different between HS and TOL patients, and no transcripts were found to be differentially expressed between the two groups. 96 transcripts were correlated with cytotoxicity by YO-PRO ( = ±.63-.75, FDR 0.188). Transcripts were selected for validation based on mechanistic plausibility and three were significantly over-expressed by qPCR in high cytotoxicity patients: multi-specific organic anion transporter C ( ), mitoferrin-1 ( ), and Porimin ( ). These data identify novel transcripts that could contribute to sulfonamide-hydroxylamine induced cytotoxicity. These include , encoding a mitochondrial iron transporter, , encoding an arylamine drug transporter, and , encoding a transmembrane protein that mediates cell death.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.1002/prp2.388

  10 / 245920 MEDLINE  
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[PMID]: 29511126
[Au] Autor:Cao S; Hua Y; Keep RF; Chaudhary N; Xi G
[Ad] Address:From the Department of Neurosurgery (S.C., Y.H., R.F.K., N.C., G.X.) and Department of Radiology (N.C.), University of Michigan, Ann Arbor; and Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China (S.C.).
[Ti] Title:Minocycline Effects on Intracerebral Hemorrhage-Induced Iron Overload in Aged Rats: Brain Iron Quantification With Magnetic Resonance Imaging.
[So] Source:Stroke;, 2018 Mar 06.
[Is] ISSN:1524-4628
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND AND PURPOSE: Brain iron overload is a key factor causing brain injury after intracerebral hemorrhage (ICH). This study quantified brain iron levels after ICH with magnetic resonance imaging R2* mapping. The effect of minocycline on iron overload and ICH-induced brain injury in aged rats was also determined. METHODS: Aged (18 months old) male Fischer 344 rats had an intracerebral injection of autologous blood or saline, and brain iron levels were measured by magnetic resonance imaging R2* mapping. Some ICH rats were treated with minocycline or vehicle. The rats were euthanized at days 7 and 28 after ICH, and brains were used for immunohistochemistry and Western blot analyses. Magnetic resonance imaging (T2-weighted, T2* gradient-echo, and R2* mapping) sequences were performed at different time points. RESULTS: ICH-induced brain iron overload in the perihematomal area could be quantified by R2* mapping. Minocycline treatment reduced brain iron accumulation, T2* lesion volume, iron-handling protein upregulation, neuronal cell death, and neurological deficits ( <0.05). CONCLUSIONS: Magnetic resonance imaging R2* mapping is a reliable and noninvasive method, which can quantitatively measure brain iron levels after ICH. Minocycline reduced ICH-related perihematomal iron accumulation and brain injury in aged rats.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:Publisher


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