Database : MEDLINE
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[PMID]: 29511370
[Au] Autor:Seo EH; Song GY; Namgung JH; Oh CS; Lee SH; Kim SH
[Ad] Address:BK21 Plus, Department of Cellular and Molecular Medicine, Konkuk University School of Medicine, Seoul, Korea.
[Ti] Title:Receptor for activated C kinase 1 in rats with ischemia-reperfusion injury: intravenous versus inhalation anaesthetic agents.
[So] Source:Int J Med Sci;15(4):352-358, 2018.
[Is] ISSN:1449-1907
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:: The study examined the difference in the expression of the receptor for activated C kinase 1 (RACK1) between anaesthesia with propofol and isoflurane in rats with myocardial ischemia-reperfusion injury (IRI). : Male Sprague-Dawley rats were studied. Anaesthesia was induced with xylazine 20 µg/g by intraperitoneal injection and maintained with propofol or isoflurane. Myocardial IRI was induced by ligating the left anterior descending artery for 1 hour. Reactive oxygen species (ROS), cardiomyocyte apoptosis, the expression of RACK1 and toll-like receptor 4 (TLR4), and the heart injury score were compared between the two groups. : Cardiomyocyte apoptosis with ROS was significantly lower in the propofol group than in the isoflurane group. The propofol group had significantly higher RACK1 expression and lower TLR4 expression, compared with the isoflurane group (RACK1, 1970.50 ± 120.50 . 1350.20 ± 250.30, <0.05; TLR4, 980.50 ± 110.75 . 1275.50 ± 75.35, <0.05). However, the heart injury scores in the two groups did not differ significantly (3.56 ± 0.29 . 4.33 ± 0.23 in the propofol and isoflurane groups, respectively, =0.33). : There were significant differences in inflammation and apoptosis, including the expression of RACK1 and TLR4, after myocardial IRI between the propofol and isoflurane groups. However, both groups had similar heart injury scores.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.7150/ijms.22591

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[PMID]: 29506576
[Au] Autor:Söbbeler FJ; Carrera I; Pasloske K; Ranasinghe MG; Kircher P; Kästner SBR
[Ad] Address:Small Animal Clinic (Söbbeler, Kästner), University of Veterinary Medicine Hanover Foundation, Bünteweg 9, 30559, Hannover, Germany. franz.josef.soebbeler@tiho-hannover.de.
[Ti] Title:Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy ( H MRS).
[So] Source:BMC Vet Res;14(1):69, 2018 Mar 05.
[Is] ISSN:1746-6148
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The purpose of this study was to determine the effects of isoflurane, sevoflurane, propofol and alfaxalone on the canine brain metabolite bioprofile, measured with single voxel short echo time proton magnetic resonance spectroscopy at 3 Tesla. Ten adult healthy Beagle dogs were assigned to receive isoflurane, sevoflurane, propofol and alfaxalone at 3 different dose rates each in a randomized cross-over study design. Doses for isoflurane, sevoflurane, propofol and alfaxalone were F 'Iso 1.7 vol%, 2.1 vol%, 2.8 vol%, F 'Sevo 2.8 vol%, 3.5 vol% and 4.7 vol%, 30, 45 and 60 mg kg h and 10, 15 and 20 mg kg h respectively. A single voxel Point Resolved Spectroscopy Sequence was performed on a 3 T MRI scanner in three brain regions (basal ganglia, parietal and occipital lobes). Spectral data were analyzed with LCModel. Concentration of total N-acetylaspartate (tNAA), choline, creatine, inositol and glutamine and glutamate complex (Glx) relative to water content was obtained. Plasma concentration of lactate, glucose, triglycerides, propofol and alfaxalone were determined. Statistics were performed using repeated measures ANOVA or Wilcoxon Sign Rank test with alpha = 5%. RESULTS: Plasma glucose increased with isoflurane, sevoflurane and alfaxalone but decreased with propofol. Plasma lactate increased with all anesthetics (isoflurane > sevoflurane > propofol > alfaxalone). Cerebral lactate could not be detected. Only minor changes in cerebral metabolite concentrations of tNAA, choline, inositol, creatine and Glx occurred with anesthetic dose changes. CONCLUSION: The metabolomic profile detected with proton magnetic resonance spectroscopy at 3 Tesla of canine brain showed only minor differences between doses and anesthetics related to tNAA, choline, creatine, inositol and Glx.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.1186/s12917-018-1396-1

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[PMID]: 29505513
[Au] Autor:Zou YQ; Li XB; Yang ZX; Zhou JM; Wu YN; Zhao ZH; Liu XZ; Hu CL
[Ad] Address:Department of Anesthesiology and Intensive Care Unit, the 476 Hospital of Fuzhou General Hospital.
[Ti] Title:Impact of inhalational anesthetics on postoperative cognitive function: Study protocol of a systematic review and meta-analysis.
[So] Source:Medicine (Baltimore);97(1):e9316, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Conflict findings of the impact of inhalational anesthetics on postoperative cognitive function are reported. No systematic review has been performed to solve the problem. The aim of the study was to assess the effect of different inhalational anesthetics on postoperative cognitive function in a network meta-analysis. METHODS: We will search MEDLINE, EMBASE, the Central Register of Controlled Trials in the Cochrane library, and CINAHL for randomized controlled trials or cohort studies assessing the short-term or long-term cognitive function of elderly patients (over 60 years) receiving major surgeries and inhalational anesthetics (desflurane, isoflurane, sevoflurane, halothane, and nitrous oxide) during surgery. Two reviewers will independently screen study eligibility, extract information from eligible studies, and appraise study quality. The impact of inhalational anesthetics will be assessed through: incidence of postoperative cognitive dysfunction at 1 week, 3 months, 1 year, and over 1 year after surgery; incidence of post-operative delirium; test of postoperative cognitive function. RESULTS: The results of this systematic review and meta-analysis will be published in a peer-reviewed journal. CONCLUSION: To our knowledge, this systematic review will be the first to evaluate existing research on the incidence of postoperative cognitive function after inhalational anesthetics. Our study will assess the effect of different inhalational anesthetics on postoperative cognitive function. ETHICS AND DISSEMINATION: The review will be finished in December 2017, and the result will be published in a peer-reviewed journal or disseminated through conference posters or abstracts. REVIEW REGISTRATION NUMBER: CRD42017056675 (www.crd.york.ac.uk/PROSPERO).
[Mh] MeSH terms primary: Anesthetics, Inhalation/adverse effects
Cognition/drug effects
[Mh] MeSH terms secundary: Humans
[Pt] Publication type:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Name of substance:0 (Anesthetics, Inhalation)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009316

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[PMID]: 29242980
[Au] Autor:Jafari A; Bargeshadi R; Jafari F; Mohebbi I; Hajaghazadeh M
[Ad] Address:Department of Occupational Health, School of Health, Urmia University of Medical Sciences, Urmia, Iran.
[Ti] Title:Environmental and biological measurements of isoflurane and sevoflurane in operating room personnel.
[So] Source:Int Arch Occup Environ Health;91(3):349-359, 2018 Apr.
[Is] ISSN:1432-1246
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: The present study aimed to compare the concentration of isoflurane and sevoflurane in the individual's breathing zone and ambient air of operating rooms (ORs), to investigate the correlation between breathing zone levels and urinary concentrations, and to evaluate the ORs pollution in the different working hours and weeks. METHODS: Environmental and biological concentrations of isoflurane and sevoflurane were evaluated at 9ORs. Air samples were collected by active sampling method and urine samples were collected from each subject at the end of the work shift. All samples were analyzed using gas chromatography. RESULTS: The geometric mean ± GSD concentration of isoflurane and sevoflurane in breathing zone air were 1.41 ± 2.27 and 0.005 ± 1.74 ppm, respectively, while in post-shift urine were 2.42 ± 2.86 and 0.006 ± 3.83 µg/l , respectively. A significant positive correlation was found between the urinary and environmental concentration of isoflurane (r = 0.724, P < 0.0001). The geometric mean ± GSD values of isoflurane and sevoflurane in ambient air were 2.30 ± 2.43 and 0.004 ± 1.56 ppm, respectively. The isoflurane concentration was different for three studied weeks and significantly increased over time in the ambient air of ORs. CONCLUSIONS: The occupational exposure of OR personnel to isoflurane and sevoflurane was lower than national recommended exposure limits. The urinary isoflurane could be a good internal dose biomarker for monitoring of occupational isoflurane exposure. Considering the accumulation of anesthetic waste gases in the studied ORs, real-time air monitoring is better to be done at the end of the work shift.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review
[do] DOI:10.1007/s00420-017-1287-y

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[PMID]: 29519127
[Au] Autor:Zaitsu K; Hayashi Y; Murata T; Yokota K; Ohara T; Kusano M; Tsuchihashi H; Ishikawa T; Ishii A; Ogata K; Tanihata H
[Ti] Title:In vivo real-time monitoring system using probe electrospray ionization/tandem mass spectrometry (PESI/MS/MS) for metabolites in mouse brain.
[So] Source:Anal Chem;, 2018 Mar 09.
[Is] ISSN:1520-6882
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Recent improvements in ambient ionization techniques combined with mass spectrometry has enabled to achieve real-time monitoring of analytes of interest, even for biogenic molecules in living animals. Here, we demonstrate a newly-developed system for in vivo real-time monitoring of metabolites in a living mouse brain. It consists of a semi-automated manipulation system and a unique probe electrospray ionization unit, which uses an extremely thin solid needle (tip dia.: 700 nm) for direct sampling and ionization, coupled to a conventional tandem mass spectrometer. The system successfully monitored 8 cerebrum metabolites related to central energy metabolism in an isoflurane-anesthetized mouse in real time with a 20-second interval. Moreover, our system succeeded in capturing dynamics of energy metabolism in a mouse administered with cannabinoid type-1 receptor agonist, which is known to disrupt cerebrum energy metabolism. The present system now opens the door to the next stage of cutting-edge technique in achieving in vivo real-time monitoring.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1021/acs.analchem.7b05291

  6 / 13428 MEDLINE  
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[PMID]: 29517440
[Au] Autor:Costa Á; Volpato J; Mattoso CRS; Lunardeli B; de Moraes AN; Saito ME
[Ti] Title:HEMATOLOGIC EVALUATION IN GUANS ( PENELOPE OBSCURA) UNDER PHYSICAL RESTRAINT AND ISOFLURANE ANESTHESIA.
[So] Source:J Zoo Wildl Med;49(1):48-53, 2018 Mar.
[Is] ISSN:1042-7260
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hematology is an important health indicator in birds, but the stress from capture or anesthesia can cause alterations in blood count. This study aimed to evaluate the differences found in blood counts among guans ( Penelope obscura) under physical restraint and anesthetized with isoflurane. Thirty-two free-range guans from the Brazilian Institute of Environment and Renewable Natural Resources (IBAMA) Park were enrolled in the study. After physical restraint, blood samples were obtained from the ulnar vein and placed in heparinized tubes. The birds were anesthetized with isoflurane and after 45 min, when the animals were still anesthetized, a blood sample from the jugular vein was collected. Data were analyzed by paired t-test, and the differences were analyzed with Tukey's test. Decreases in red blood cell counts, hemoglobin concentrations, and packed cell volumes, and increased mean corpuscular hemoglobin concentrations were observed when animals were under general anesthesia. Decreases in total plasma protein, fibrinogen, and thrombocytes were detected after anesthesia. It was concluded that isoflurane influences the hematologic parameters, and those effects should be considered when interpreting hematologic values.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1638/2016-0125R2.1

  7 / 13428 MEDLINE  
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[PMID]: 29318795
[Au] Autor:Kim JD; Son I; Kwon WK; Sung TY; Sidik H; Kim K; Kang H; Bang J; Yeo GE; Lee DK; Kim TY
[Ad] Address:Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Korea.
[Ti] Title:Isoflurane's Effect on Intraoperative Systolic Left Ventricular Performance in Cardiac Valve Surgery Patients.
[So] Source:J Korean Med Sci;33(4):e28, 2018 01 22.
[Is] ISSN:1598-6357
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:BACKGROUND: Isoflurane, a common anesthetic for cardiac surgery, reduced myocardial contractility in many experimental studies, few studies have determined isoflurane's direct impact on the left ventricular (LV) contractile function during cardiac surgery. We determined whether isoflurane dose-dependently reduces the peak systolic velocity of the lateral mitral annulus in tissue Doppler imaging (S') in patients undergoing cardiac surgery. METHODS: During isoflurane-supplemented remifentanil-based anesthesia for patients undergoing cardiac surgery with preoperative LV ejection fraction greater than 50% (n = 20), we analyzed the changes of S' at each isoflurane dose increment (1.0, 1.5, and 2.0 minimum alveolar concentration [MAC]: T1, T2, and T3, respectively) with a fixed remifentanil dosage (1.0 µg/min/kg) by using transesophageal echocardiography. RESULTS: Mean S' values (95% confidence interval [CI]) at T1, T2, and T3 were 10.5 (8.8-12.2), 9.5 (8.3-10.8), and 8.4 (7.3-9.5) cm/s, respectively (P < 0.001 in multivariate analysis of variance test). Their mean differences at T1 vs. T2, T2 vs. T3, and T1 vs. T3 were -1.0 (-1.6, -0.3), -1.1 (-1.7, -0.6), and -2.1 (-3.1, -1.1) cm/s, respectively. Phenylephrine infusion rates were significantly increased (0.26, 0.22, and 0.47 µg/kg/min at T1, T2, and T3, respectively, P < 0.001). CONCLUSION: Isoflurane increments (1.0-2.0 MAC) dose-dependently reduced LV systolic long-axis performance during cardiac surgeries with a preserved preoperative systolic function.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Process
[do] DOI:10.3346/jkms.2018.33.e28

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[PMID]: 29452810
[Au] Autor:Hu J; Feng X; Valdearcos M; Lutrin D; Uchida Y; Koliwad SK; Maze M
[Ad] Address:Department of Anesthesia and Perioperative Care and Center for Cerebrovascular Research, University of California, San Francisco, CA, USA; Department of Anesthesia, Tongling People's Hospital, Tongling, Anhui 244000, People's Republic of China.
[Ti] Title:Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice.
[So] Source:Br J Anaesth;120(3):537-545, 2018 Mar.
[Is] ISSN:1471-6771
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Perioperative neurocognitive disorders (PND) result in long-term morbidity and mortality with no effective interventions available. Because interleukin-6 (IL-6), a pro-inflammatory cytokine, is consistently up-regulated by trauma, including after surgery, we determined whether IL-6 is a putative therapeutic target for PND in a mouse model. METHODS: Following institutional approval, adult (12-14 weeks) male C57/Bl6 mice were pretreated with the IL-6 receptor (IL6R) blocking antibody tocilizumab prior to open tibia fracture with internal fixation under isoflurane anaesthesia. Inflammatory and behavioural responses in a trace fear conditioning (TFC) paradigm were assessed postoperatively. Separately, the effects of IL-6 administration or of depletion of bone marrow-derived monocytes (BM-DMs) with clodrolip on the inflammatory and behavioural responses were assessed. Blood brain barrier disruption, hippocampal microglial activation, and infiltration of BM-DMs were each assessed following IL-6 administration. RESULTS: The surgery-induced decrement in freezing time in the TFC assay, indicative of cognitive decline, was attenuated by tocilizumab (P<0.01). The surgery-induced increase in pro-inflammatory mediators was significantly reduced by tocilizumab. Exogenously administered IL-6 significantly impaired freezing behaviour (P<0.05) and up-regulated pro-inflammatory cytokines; both responses were prevented by depletion of BM-DMs. IL-6 disrupted the blood brain barrier, and increased hippocampal activation of microglia and infiltration of BM-DMs. CONCLUSIONS: IL-6 is both necessary and sufficient to produce cognitive decline. Following further preclinical testing of its perioperative safety, the IL6R blocker tocilizumab is a candidate for prevention and/or treatment of PND.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

  9 / 13428 MEDLINE  
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[PMID]: 29508167
[Au] Autor:Rand A; Zahn PK; Schildhauer TA; Waydhas C; Hamsen U
[Ad] Address:BG Universitätsklinikum Bergmannsheil, Klinik für Anästhesiologie, Intensiv-, Palliativ- und Schmerzmedizin, Bochum, Germany. axel.rand@gmail.com.
[Ti] Title:Inhalative sedation with small tidal volumes under venovenous ECMO.
[So] Source:J Artif Organs;, 2018 Mar 05.
[Is] ISSN:1619-0904
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:BACKGROUND: Inhalative sedation is an emerging method for long-term sedation in intensive care therapy. There is evidence that it is easy to control and may be beneficial compared to intravenous sedation. Yet little is known about the use in patients with compromised lung function. In this retrospective analysis, we searched files of patients receiving inhalative sedation under venovenous extracorporeal membrane oxygenator (vv-ECMO) support due to lung failure. METHODS: After ethical approval, we performed a retrospective analysis of patients receiving vv-ECMO support and inhalative sedation in the surgical ICU in 2015. Isoflurane was administered via the AnaConDa®-system. Sedation was tested using Richmond Agitation and Sedation scale (RASS). RESULTS: 7 patients were identified. Median age was 50 years (26/70 years). All were male. Median ECMO runtime was 129 h (37/1008 h) and the survival rate was 57.9%. Dose of isoflurane was 1.7 ml/h (0.8 / 4.0 ml/h) resulting in expiratory concentrations of 0.8 Vol% (0.3/1.8 Vol%), inspiratory of 0.6 Vol% (0.1/1.4 Vol%). Higher concentrations of isoflurane were associated with increased depth of sedation (expiratory p = 0.016; inspiratory p = 0.027; averaged p = 0.015). With tidal volume below 350 ml, association was still present for expiratory and averaged concentrations of isoflurane (expiratory p = 0.031; inspiratory p = 0.082; average p = 0.039). CONCLUSIONS: This is the first study that shows that inhalative concentrations of isoflurane are associated with depth of sedation in patients with lung failure. We were able to show that even with major impacts in lung mechanics and function targeted sedation with volatile anaesthetics is feasible and dose-response relationship appears to exist.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1007/s10047-018-1030-9

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[PMID]: 29505303
[Au] Autor:Woll KA; Zhou X; Bhanu NV; Garcia BA; Covarrubias M; Miller KW; Eckenhoff RG
[Ad] Address:Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
[Ti] Title:Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors.
[So] Source:FASEB J;:fj201701347R, 2018 Mar 05.
[Is] ISSN:1530-6860
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Most general anesthetics enhance GABA type A (GABA ) receptor activity at clinically relevant concentrations. Sites of action of volatile anesthetics on the GABA receptor remain unknown, whereas sites of action of many intravenous anesthetics have been identified in GABA receptors by using photolabeling. Here, we used photoactivatable analogs of isoflurane (AziISO) and sevoflurane (AziSEVO) to locate their sites on α ß Î³ and α ß GABA receptors. As with isoflurane and sevoflurane, AziISO and AziSEVO enhanced the currents elicited by GABA. AziISO and AziSEVO each labeled 10 residues in α ß receptors and 9 and 8 residues, respectively, in α ß Î³ receptors. Photolabeled residues were concentrated in transmembrane domains and located in either subunit interfaces or in the interface between the extracellular domain and the transmembrane domain. The majority of these transmembrane residues were protected from photolabeling with the addition of excess parent anesthetic, which indicated specificity. Binding sites were primarily located within α+/ß- and ß+/α- subunit interfaces, but residues in the α+/γ- interface were also identified, which provided a basis for differential receptor subtype sensitivity. Isoflurane and sevoflurane did not always share binding sites, which suggests an unexpected degree of selectivity.-Woll, K. A., Zhou, X., Bhanu, N. V., Garcia, B. A., Covarrubias, M., Miller, K. W., Eckenhoff, R. G. Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1096/fj.201701347R


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