Database : MEDLINE
Search on : korsakoff and syndrome [Words]
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[PMID]: 29188542
[Au] Autor:Tanabe N; Hiraoka E; Kataoka J; Naito T; Matsumoto K; Arai J; Norisue Y
[Ad] Address:Department of Internal Medicine, Tokyo Bay Urayasu Ichikawa Medical Center, 3-4-32, Todaijima, Urayasu-city, Chiba, 279-0001, Japan.
[Ti] Title:Wet Beriberi Associated with Hikikomori Syndrome.
[So] Source:J Gen Intern Med;33(3):384-387, 2018 Mar.
[Is] ISSN:1525-1497
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Wet beriberi, characterized by high cardiac output with predominantly right-sided heart failure and lactic acidosis, is a disease caused by thiamine deficiency, and is rarely seen in modern society. However, patients with social withdrawal syndrome, also known as hikikomori syndrome, may be a new population at risk of thiamine deficiency. Hikikomori syndrome, first recognized in Japan, is becoming a worldwide issue. A 39-year-old Japanese patient was brought to our hospital, with a 3-week history of progressive shortness of breath and generalized edema. The patient had right-sided high-output heart failure, lactic acidosis, and Wernicke-Korsakoff syndrome. Because of his history of social isolation, we diagnosed hikikomori syndrome according to the Japanese government's definition, which is as follows: lifestyle centered at home; no interest or willingness to attend school or work; persistence of symptoms beyond 6 months; and exclusion of other psychiatric and developmental disorders. Considering his diagnosis of hikikomori syndrome and social isolation, we suspected malnutrition, particularly thiamine deficiency, and successfully treated him. Clinicians should be aware of the potential risk of thiamine deficiency associated with hikikomori syndrome and initiate thiamine replacement in cases of high-output heart failure associated with lactic acidosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1007/s11606-017-4208-6

  2 / 1243 MEDLINE  
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[PMID]: 29509075
[Au] Autor:Brion M; Dormal V; Lannoy S; Mertens S; de Timary P; Maurage P
[Ad] Address:a Laboratory for Experimental Psychopathology, Psychological Sciences Research Institute , Université catholique de Louvain , Louvain-la-Neuve , Belgium.
[Ti] Title:Imbalance between cognitive systems in alcohol-dependence and Korsakoff syndrome: An exploration using the Alcohol Flanker Task.
[So] Source:J Clin Exp Neuropsychol;:1-12, 2018 Mar 06.
[Is] ISSN:1744-411X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Alcohol-dependent individuals (ALC) simultaneously present decreased inhibitory control and increased attention towards alcohol-related cues. The dual-process models have proposed that these symptoms reflect an imbalance between prefrontal/reflective and limbic/automatic systems, respectively leading to cognitive dysfunctions in executive processes and to alcohol-related bias. However, most previous research has focused on a separate exploration of these systems among ALC, and the direct measure of their interactions remains to be conducted. Moreover, no study has explored the evolution of this imbalance across the successive stages of alcohol-related disorders, and particularly in Korsakoff syndrome (KS), the most frequent neurological complication of alcohol-dependence. METHOD: Ten KS, 14 ALC, and 14 matched control participants performed a modified Flanker task, the "Alcohol Flanker Task," based on congruent, incongruent, and neutral conditions with alcohol-related stimuli. This task required inhibitory processing on alcohol-related stimuli and evaluated, through a behavioral approach, the interaction between reflective and automatic systems, as well as its evolution between ALC and KS. RESULTS: ALC and KS both presented high reactivity towards alcohol-related stimuli, confirming the presence of alcohol-related bias. KS showed increased omission rates (related to distractor interference) while ALC showed higher false-alarm rates (related to prepotent response inhibition). These results suggest that different inhibitory subcomponents might be altered at the successive stages of the pathology, and experimentally confirms the crucial role of the interaction between reflective and automatic processes in alcohol-use disorders. CONCLUSION: The present results reinforce the proposal that alcohol-related cues significantly impact inhibitory control in alcohol-related disorders. However, ALC and KS present different patterns of deficits depending on task complexity (i.e., executive load), thus suggesting a dissociation in inhibitory functions when processing alcohol-related cues.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1080/13803395.2018.1438371

  3 / 1243 MEDLINE  
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[PMID]: 29501971
[Au] Autor:El Haj M; Nandrino JL
[Ad] Address:Univ. Lille, CNRS, CHU Lille, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, F-59000 Lille, France; Unité de Gériatrie, Centre Hospitalier de Tourcoing, Tourcoing, France. Electronic address: mohamad.elhaj@univ-lille3.fr.
[Ti] Title:Seeing life through rose-colored spectacles: Autobiographical memory as experienced in Korsakoff's syndrome.
[So] Source:Conscious Cogn;60:9-16, 2018 Mar 01.
[Is] ISSN:1090-2376
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We investigated whether patients with Korsakjoff's Sybdrome (KS) would demonstrate a discrepancy between (low) autobiographical specificity and (high) sense of reliving. We invited 20 KS patients and 24 controls to retrieve personal memories. After memory retrieval, they were invited to rate subjective characteristics of their recall (e.g., reliving, travel in time, remembering, realness). Besides this rating, we analyzed memories objectively with regard to specificity. Analysis demonstrated poorer sense of reliving and memory specificity in KS patients than in controls. Critically, a discrepancy (i.e., higher level of sense of reliving than of specificity) was observed in KS participants but not in controls. We propose a hypothesis of "genuine consciousness experience" in which the discrepancy between sense of reliving and specificity mirrors how KS patients can benefit from an authentic experience of the past despite compromise in their autobiographical recall.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher

  4 / 1243 MEDLINE  
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[PMID]: 29482863
[Au] Autor:Nakamura ZM; Tatreau JR; Rosenstein DL; Park EM
[Ad] Address:Department of Psychiatry, University of North Carolina, Chapel Hill, NC. Electronic address: zev.nakamura@unchealth.unc.edu.
[Ti] Title:Clinical Characteristics and Outcomes Associated With High-Dose Intravenous Thiamine Administration in Patients With Encephalopathy.
[So] Source:Psychosomatics;, 2018 Jan 11.
[Is] ISSN:1545-7206
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Wernicke encephalopathy is a common neuropsychiatric syndrome due to thiamine deficiency. There is no consensus regarding thiamine dosing when Wernicke encephalopathy is suspected. A longstanding dosing strategy for Wernicke encephalopathy is 100mg daily, yet updated clinical guidelines suggest using high-dose intravenous (HDIV) thiamine. OBJECTIVE: To describe thiamine prescribing practices at a large, public academic hospital and investigate clinical characteristics and outcomes associated with HDIV thiamine in patients with encephalopathy who received IV thiamine. METHODS: Electronic medical records of hospitalized patients who received thiamine between 4/4/2014 and 11/1/2015 were reviewed. Chi-square tests, Wilcoxon Rank Sum tests, and logistic regression were used to compare clinical variables in patients with encephalopathy who received HDIV thiamine (≥ 200mg twice daily) vs lower doses of IV thiamine. RESULTS: Among the total of 5236 thiamine orders, 29% (n = 1531) were IV; 10% (n = 150) of IV orders met HDIV criteria. In patients with encephalopathy who received IV thiamine (n = 432), HDIV thiamine was administered to 20% (n = 86) and only 2.1% (n = 9) received dosing consistent with Royal College of Physicians guidelines. In bivariable analyses, HDIV thiamine was associated with surgical services (p = 0.001), psychiatric consultation (p < 0.001), and decreased mortality (p = 0.004). In multivariable models, the association between HDIV thiamine and decreased in-hospital mortality did not meet statistical significance (p = 0.061). CONCLUSIONS: In a large, public academic hospital, guideline-concordant thiamine supplementation is rare and HDIV thiamine is infrequently prescribed to patients with encephalopathy. Further studies are needed to confirm the possible benefits of HDIV thiamine for patients with suspected thiamine-deficient encephalopathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher

  5 / 1243 MEDLINE  
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[PMID]: 29380664
[Au] Autor:Bielewicz J; Szczepanska-Szerej A; Ogórek M; Dropko P; Wojtal K; Rejdak K
[Ad] Address:a Department of Neurology , Medical University of Lublin , Lublin , Poland.
[Ti] Title:Wernicke-Korsakoff syndrome as a rare phenotype of sporadic Creutzfeldt-Jakob disease.
[So] Source:Prion;:1-4, 2018 Feb 09.
[Is] ISSN:1933-690X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We reported the case of a patient with Wernicke-Korsakoff syndrome (WKs) as an early clinical manifestation of sporadic Creutzfeld-Jakob disease (sCJD). The 66-year-old female complained of dizziness and imbalance which mostly occurred while walking. A neurological examination revealed a triad of symptoms characteristic for WKs such as gaze paresis, ataxia of limbs and trunk as well as memory disturbances with confabulations. The disturbances increased during the course of the disease, which led to the death of the patient four months after the appearance of the signs. The patient was finally diagnosed with sCJD disease. The most useful ancillary examination results supporting sCJD diagnosis were brain diffusion DWI MRI (diffusion weighted magnetic resonance imaging) and the presence of 14-3-3 protein in CSF (cerebrospinal fluid). Since that manifestation of sCJD is very unique other causes should be taken into consideration while making a final diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:Publisher
[do] DOI:10.1080/19336896.2018.1433988

  6 / 1243 MEDLINE  
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[PMID]: 29400641
[Au] Autor:Diekfuss JA; De Larwelle J; McFadden SH
[Ad] Address:a The SPORT Center, Division of Sports Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati , OH.
[Ti] Title:Diagnosis makes a difference: Perceptions of older persons with dementia symptoms.
[So] Source:Exp Aging Res;44(2):148-161, 2018 Mar-Apr.
[Is] ISSN:1096-4657
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Background/Study Context: Employing the stereotype content model and terror management theory, we examined whether stereotypes and feelings about persons with dementia vary depending on the type of dementia diagnosis and purported causes of the dementia. METHODS: Participants were randomly assigned to read one of four vignettes that depicted a man who consulted his doctor because of memory problems. All vignettes described the same symptoms and diagnostic tests, but each of four groups read a different result: all tests normal (Normal); Alzheimer's disease (AD); Wernicke-Korsakoff Syndrome (WKS) associated with alcohol abuse; and chronic traumatic encephalopathy (CTE) associated with head injuries from playing football in high school and college. Measures included a word fragment completion task, a stereotype content scale, and an emotions scale. RESULTS: Results showed no differences in the number of death-related words generated in the word fragment completion task and no differences in assessment of competence across the four groups. Those in the Normal, AD, and CTE groups evaluated the man as warmer than those in the WKS group. Participants in the AD condition showed more empathy than those in the WKS group. There were no differences in pity or fear but the CTE condition produced more envy and admiration and the WKS condition produced more contempt. CONCLUSION: These results suggest that different forms of dementia elicit varying emotional and cognitive responses.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:In-Data-Review
[do] DOI:10.1080/0361073X.2017.1422475

  7 / 1243 MEDLINE  
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[PMID]: 29411941
[Au] Autor:Stanciu MA; Rafal RD; Turnbull OH
[Ad] Address:School of Psychology, Bangor, Gwynedd, UK.
[Ti] Title:Preserved re-experience of discrete emotions: Amnesia and executive function.
[So] Source:J Neuropsychol;, 2018 Feb 07.
[Is] ISSN:1748-6653
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Amnesic patients can re-experience emotions elicited by forgotten events, suggesting that brain systems for episodic and emotional memory are independent. However, the range of such emotional memories remains under-investigated (most studies employing just positive-negative emotion dyads), and executive function may also play a role in the re-experience of emotions. This is the first investigation of the intensity of the emotional re-experience of a range of discrete emotions (anger, fear, sadness, and happiness) for a group of amnesic patients. Twenty Korsakoff syndrome (KS) patients and 20 neurologically normal controls listened to four novel emotional vignettes selectively eliciting the four basic emotions. Emotional experience was measured using pen-and-paper Visual Analogue Mood Scales and episodic memory using verbal recollections. After 30 min, the recollection of stories was severely impaired for the patient group, but the emotional re-experience was no different from that of controls. Notably, there was no relationship between episodic recall and the intensity of the four emotions, such that even profoundly amnesic patients reported moderate levels of the target emotion. Exploratory analyses revealed negative correlations between the intensity of basic emotions and executive functions (e.g., cognitive flexibility and response inhibition) for controls but not patients. The results suggest that discrete emotions can be re-experienced independently of episodic memory, and that the re-experience of certain discrete emotions appears to be dampened by executive control. KS patients with absent or mild cognitive symptoms should benefit from emotion-regulation interventions aimed at reducing the recognized affective burden associated with their episodic memory deficit.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:Publisher
[do] DOI:10.1111/jnp.12147

  8 / 1243 MEDLINE  
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[PMID]: 29283625
[Au] Autor:Greenwald AG; Banaji MR
[Ad] Address:Department of Psychology, University of Washington.
[Ti] Title:The implicit revolution: Reconceiving the relation between conscious and unconscious.
[So] Source:Am Psychol;72(9):861-871, 2017 Dec.
[Is] ISSN:1935-990X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In the 1970s, memory researchers converged on interesting phenomena observed in Korsakoff-syndrome amnesic patients. These patients' performances on difficult tasks were reliably improved by practice sessions from which they could recall nothing. Related findings of indirect memory effects in college students triggered wide attention to phenomena that, in 1985, were first identified as implicit memory. Within a decade, the indirect measurement methods of implicit memory research had spread to social psychologists' studies of attitudes and stereotypes. After another two decades, the methods and findings of this developing revolution have revised understanding of how past learning, operating in ways that bypass conscious awareness, nevertheless shapes conscious judgment and perception. This revolution in psychological thinking is on the cusp of reconceiving the relation between unconscious and conscious mental process. Further, it demands researchers' careful attention to justification for many self-report measures that are now routinely treated as face-valid. (PsycINFO Database Record
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171228
[Lr] Last revision date:171228
[St] Status:In-Data-Review
[do] DOI:10.1037/amp0000238

  9 / 1243 MEDLINE  
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[PMID]: 29128903
[Au] Autor:Abdul-Muneer PM; Alikunju S; Schuetz H; Szlachetka AM; Ma X; Haorah J
[Ad] Address:Laboratory of Neurovascular Inflammation and Neurodegeneration, Department of Biomedical Engineering, Center for Injury Bio Mechanics, Materials and Medicine, New Jersey Institute of Technology, 111 Lock Street, Newark, NJ, 07102, USA.
[Ti] Title:Impairment of Thiamine Transport at the GUT-BBB-AXIS Contributes to Wernicke's Encephalopathy.
[So] Source:Mol Neurobiol;, 2017 Nov 11.
[Is] ISSN:1559-1182
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Wernicke's encephalopathy, a common neurological disease, is caused by thiamine (vitamin B1) deficiency. Neuropathy resulting from thiamine deficiency is a hallmark of Wernicke-Korsakoff syndrome in chronic alcohol users. The underlying mechanisms of this deficiency and progression of neuropathy remain to be understood. To uncover the unknown mechanisms of thiamine deficiency in alcohol abuse, we used chronic alcohol consumption or thiamine deficiency diet ingestion in animal models. Observations from animal models were validated in primary human neuronal culture for neurodegenerative process. We employed radio-labeled bio-distribution of thiamine, qualitative and quantitative analyses of the various biomarkers and neurodegenerative process. In the present studies, we established that disruption of thiamine transport across the intestinal gut blood-brain barrier axis as the cause of thiamine deficiency in the brain for neurodegeneration. We found that reduction in thiamine transport across these interfaces was the cause of reduction in the synthesis of thiamine pyrophosphate (TPP), an active cofactor for pyruvate dehydrogenase E1α (PDHE1α). Our findings revealed that decrease in the levels of PDHE1α cofactors switched on the activation of PD kinase (PDK) in the brain, thereby triggering the neuronal phosphorylation of PDHE1α (p-PDHE1α). Dysfunctional phosphorylated PDHE1α causes the reduction of mitochondrial aerobic respiration that led to neurodegeneration. We concluded that impairment of thiamine transport across the gut-BBB-axis that led to insufficient TPP synthesis was critical to Wernicke-neuropathy, which could be effectively prevented by stabilizing the thiamine transporters.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171112
[Lr] Last revision date:171112
[St] Status:Publisher
[do] DOI:10.1007/s12035-017-0811-0

  10 / 1243 MEDLINE  
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[PMID]: 29128624
[Au] Autor:Di Marco S; Pilati L; Brighina F; Fierro B; Cosentino G
[Ad] Address:Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy.
[Ti] Title:Wernicke-Korsakoff syndrome complicated by subacute beriberi neuropathy in an alcoholic patient.
[So] Source:Clin Neurol Neurosurg;164:1-4, 2017 Nov 08.
[Is] ISSN:1872-6968
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Thiamine (vitamin B1) deficiency is a common condition in alcohol abusers, which can lead to damage of both the peripheral and the central nervous systems. Here we describe the case of an alcoholic patient who presented with acute onset of ataxia, severe weakness of the four limbs, and hypoesthesia and dysesthesia of the distal portion of the upper and lower extremities. The clinical picture also included mental confusion and amnesia. A diagnosis of Wernicke-Korsakoff syndrome was made based on clinical symptoms and brain RMI findings. Electromyography and electroneurography revealed signs of subacute axonal sensory-motor polyneuropathy that were compatible with a rare acute presentation of beriberi. Patient immediately received parenteral thiamine administration, which resulted in rapid clinical amelioration of ataxia and confusion and also in a significant improvement of motor and sensory deficits. The association between Wernicke-Korsakoff syndrome and acute axonal polyneuropathy is a very rare condition that could make less recognizable the clinical picture of a thiamine deficiency. However, the diagnosis of thiamine deficiency should be suspected in every alcoholic patient presenting with acute onset symptoms of central and/or peripheral nervous system involvement. This because the immediate replacement treatment can be life-saving and reverse the clinical symptoms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171112
[Lr] Last revision date:171112
[St] Status:Publisher


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