Database : MEDLINE
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[PMID]: 29506498
[Au] Autor:Zhang Y; Chen YG
[Ad] Address:Department of Ophthalmology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing, 100191, China.
[Ti] Title:High incidence of rainbow glare after femtosecond laser assisted-LASIK using the upgraded FS200 femtosecond laser.
[So] Source:BMC Ophthalmol;18(1):71, 2018 Mar 05.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: To compare the incidence of rainbow glare (RG) after femtosecond laser assisted-LASIK (FS-LASIK) using the upgraded FS200 femtosecond laser with different flap cut parameter settings. METHODS: A consecutive series of 129 patients (255 eyes) who underwent FS-LASIK for correcting myopia and/or astigmatism using upgraded WaveLight FS200 femtosecond laser with the original settings was included in group A. Another consecutive series of 129 patients (255 eyes) who underwent FS-LASIK using upgraded WaveLight FS200 femtosecond laser with flap cut parameter settings changed (decreased pulse energy, spot and line separation) was included in group B. The incidence and fading time of RG, confocal microscopic image and postoperative clinical results were compared between the two groups. RESULTS: There were no differences between the two groups in age, baseline refraction, excimer laser ablation depth, postoperative uncorrected visual acuity and refraction. The incidence rate of RG in group A (35/255, 13.73%) was significantly higher than that in group B (4/255, 1.57%) (P < 0.05). The median fading time was 3 months in group A and 1 month in group B (P > 0.05).The confocal microscopic images showed wider laser spot spacing in group A than group B. The incidence of RG was significantly correlated with age and grouping (P < 0.05). CONCLUSIONS: The upgraded FS200 femtosecond laser with original flap cut parameter settings could increase the incidence of RG. The narrower grating size and lower pulse energy could ameliorate this side effect.
[Mh] MeSH terms primary: Astigmatism/surgery
Glare
Keratomileusis, Laser In Situ/methods
Lasers, Excimer/adverse effects
Myopia/surgery
Vision Disorders/epidemiology
[Mh] MeSH terms secundary: Adult
Humans
Incidence
Keratomileusis, Laser In Situ/instrumentation
Microscopy, Confocal
Refraction, Ocular/physiology
Retrospective Studies
Surgical Flaps
Tomography, Optical Coherence
Vision Disorders/physiopathology
Visual Acuity/physiology
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[Js] Journal subset:IM
[Da] Date of entry for processing:180307
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0734-1

  2 / 92493 MEDLINE  
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[PMID]: 29501723
[Au] Autor:Gai M; Kurochkin MA; Li D; Khlebtsov BN; Dong L; Tarakina N; Poston R; Gould DJ; Frueh J; Sukhorukov GB
[Ad] Address:School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom.
[Ti] Title:In-situ NIR-laser mediated bioactive substance delivery to single cell for EGFP expression based on biocompatible microchamber-arrays.
[So] Source:J Control Release;276:84-92, 2018 Mar 07.
[Is] ISSN:1873-4995
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Controlled drug delivery and gene expression is required for a large variety of applications including cancer therapy, wound healing, cell migration, cell modification, cell-analysis, reproductive and regenerative medicine. Controlled delivery of precise amounts of drugs to a single cell is especially interesting for cell and tissue engineering as well as therapeutics and has until now required the application of micro-pipettes, precisely placed dispersed drug delivery vehicles, or injections close to or into the cell. Here we present surface bound micro-chamber arrays able to store small hydrophilic molecules for prolonged times in subaqueous conditions supporting spatiotemporal near infrared laser mediated release. The micro-chambers (MCs) are composed of biocompatible and biodegradable polylactic acid (PLA). Biocompatible gold nanoparticles are employed as light harvesting agents to facilitate photothermal MC opening. The degree of photothermal heating is determined by numerical simulations utilizing optical properties of the MC, and confirmed by Brownian motion measurements of laser-irradiated micro-particles exhibiting similar optical properties like the MCs. The amount of bioactive small molecular cargo (doxycycline) from local release is determined by fluorescence spectroscopy and gene expression in isolated C2C12 cells via enhanced green fluorescent protein (EGFP) biosynthesis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 92493 MEDLINE  
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[PMID]: 29339189
[Au] Autor:Lu JW; Yang F; Ke QF; Xie XT; Guo YP
[Ad] Address:The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
[Ti] Title:Magnetic nanoparticles modified-porous scaffolds for bone regeneration and photothermal therapy against tumors.
[So] Source:Nanomedicine;14(3):811-822, 2018 Feb 12.
[Is] ISSN:1549-9642
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:For effectively treating tumor related-bone defects, design and fabrication of multifunctional biomaterials still remain a great challenge. Herein, we firstly fabricated magnetic SrFe O nanoparticles modified-mesoporous bioglass (BG)/chitosan (CS) porous scaffold (MBCS) with excellent bone regeneration and antitumor function. The as-produced magnetic field from MBCS promoted the expression levels of osteogenic-related genes (OCN, COL1, Runx2 and ALP) and the new bone regeneration by activated BMP-2/Smad/Runx2 pathway. Moreover, the SrFe O nanoparticles in MBCS improved the photothermal conversion property. Under the irradiation of near-infrared (NIR) laser, the elevated temperatures of tumors co-cultured with MBCS triggered tumor apoptosis and ablation. As compared with the pure scaffold group, MBCS/NIR group possessed the excellent antitumor efficacy against osteosarcoma via the hyperthermia ablation. Therefore, the multifunctional MBCS with excellent bone regeneration and photothermal therapy functions has a great application for treating the tumor-related bone defects.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29329895
[Au] Autor:Cho MC; Song WH; Park J; Cho SY; Jeong H; Oh SJ; Paick JS; Son H
[Ad] Address:Department of Urology, Seoul National University Boramae Medical Center, Seoul, Korea.
[Ti] Title:Long-Term Outcomes of Laser Prostatectomy for Storage Symptoms: Comparison of Serial 5-Year Followup Data between 120 W High Performance System Photoselective Vaporization of the Prostate and Holmium Laser Enucleation of the Prostate.
[So] Source:J Urol;, 2018 Jan 09.
[Is] ISSN:1527-3792
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: We compared long-term storage symptom outcomes between photoselective laser vaporization of the prostate with a 120 W high performance system and holmium laser enucleation of the prostate. We also determined factors influencing postoperative improvement of storage symptoms in the long term. MATERIALS AND METHODS: Included in our study were 266 men, including 165 treated with prostate photoselective laser vaporization using a 120 W high performance system and 101 treated with holmium laser enucleation of the prostate, on whom 60-month followup data were available. Outcomes were assessed serially 6, 12, 24, 36, 48 and 60 months postoperatively using the I-PSS (International Prostate Symptom Score), uroflowmetry and the serum prostate specific antigen level. Postoperative improvement in storage symptoms was defined as a 50% or greater reduction in the subtotal storage symptom score at each followup visit after surgery compared to baseline. RESULTS: Improvements in frequency, urgency, nocturia, subtotal storage symptom scores and the quality of life index were maintained up to 60 months after photoselective laser vaporization or holmium laser enucleation of the prostate. There was no difference in the degree of improvement in storage symptoms or the percent of patients with postoperative improvement in storage symptoms between the 2 groups throughout the long-term followup. However, the holmium laser group showed greater improvement in voiding symptoms and quality of life than the laser vaporization group. On logistic regression analysis a higher baseline subtotal storage symptom score and a higher BOOI (Bladder Outlet Obstruction Index) were the factors influencing the improvement in storage symptoms 5 years after prostate photoselective laser vaporization or holmium laser enucleation. CONCLUSIONS: Our serial followup data suggest that storage symptom improvement was maintained throughout the long-term postoperative period for prostate photoselective laser vaporization with a 120 W high performance system and holmium laser enucleation without any difference between the 2 surgeries. Also, more severe storage symptoms at baseline and a more severe BOOI predicted improved storage symptoms in the long term after each surgery.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  5 / 92493 MEDLINE  
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[PMID]: 29524305
[Au] Autor:Fritz K; Salavastru C; Gyurova M
[Ad] Address:Dermatology and Laser Center, Landau in der Pfalz, Germany.
[Ti] Title:Clinical evaluation of simultaneously applied monopolar radiofrequency and targeted pressure energy as a new method for noninvasive treatment of cellulite in postpubertal women.
[So] Source:J Cosmet Dermatol;, 2018 Mar 09.
[Is] ISSN:1473-2165
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: This study investigates noninvasive cellulite treatments based on simultaneous application of monopolar radiofrequency (RF) and targeted pressure energy to evaluate efficacy and safety and to see whether simultaneous application has any benefits in noninvasive cellulite treatments. METHODS: Thirty women with cellulite (fibrous/adipose/aqueous types) received 4 gluteofemoral treatments (~24 minutes; ~1000 cm ) using a simultaneous application of RF and targeted pressure energy. Clinical improvement was assessed using a pentile grading scale and satisfaction questionnaires. Hip/thigh circumference was measured. Ultrasonography and thermography observed changes in dermal/subcutaneous tissue composition and in gluteofemoral thermal profile. Evaluation at 3 months posttreatment was compared against the baseline. RESULTS: The clinical improvement averaged 2.17 ± 0.95 (54% improvement). Cellulite was reduced in 93% of cases, while 73% of patients showed good/very good/excellent improvement, with most significant improvement seen in patients with moderately severe cellulite. Hips and thigh circumference decreased on average by 2.31 cm and 2.13 cm, respectively (P < .001). Patient satisfaction was very high, averaging 4.47 ± 0.57 points (1-5 scale). Ultrasonography revealed smoothing and thickening (+0.28 ± 0.15 mm) of the dermis and an average reduction of 1.96 ± 1.60 mm in fat thickness (P < .05). Subjects with significant cellulite reduction had a more homogenous thermal profile at follow-up as a result of therapy-induced diminution of topographic skin defects. No adverse events were recorded. CONCLUSION: The application is effective and safe for treating cellulite. The level of clinical improvement after 4 sessions is comparable to results reported after 6-20 sessions in studies on stand-alone RF/laser/targeted pressure energy devices. The technology is promising and deserves further attention and research.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1111/jocd.12525

  6 / 92493 MEDLINE  
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[PMID]: 29522303
[Au] Autor:Mosiejczuk H; Bak K; Szylinska A; Ptak M; Mikolajczyk A; Lubinska A; Turon A; Ciosek Z; Rotter I
[Ti] Title:[Effect of low -level laser therapy and exercise in reducing the symptoms of disease in patients with osteoarthritis of the knee].
[So] Source:Pomeranian J Life Sci;61(4):368-74, 2015.
[Is] ISSN:2450-4637
[Cp] Country of publication:Poland
[La] Language:pol
[Ab] Abstract:Introduction: Osteoarthritis is the most common disease of the joints contributing to the failure of movement. The disease mostly affects the older part of the population, and is associated with suffering and reduced quality of life. Knee osteoarthritis contributes to joint dysfunction of varying severity. These are common causes of chronic ailments limiting physical activity, which may even complicate the performance of activities of daily living. Low-level laser therapy is thought to have an analgesic effect, as well as a biomodulatory effect on the microcirculation. The aim of this study was to evaluate the effectiveness of low- -level laser therapy on pain relief and functional improvement in patients with osteoarthritis of the knee. The effects of laser therapy alone and in combination with exercise were compared. Materials and methods: 40 patients of mean age 65 years with knee osteoarthritis of both sexes were divided into two groups. Laser alone was used in group I (n = 20) and laser combined with kinesistherapy was used in group II (n = 20). All patients received the same dose of laser radiation, which was 3.0 J/cm², 10 Hz, 400 mW. In both groups a series of 10 treatments was performed daily. VAS, ranges of motion in the knee joint, and the strength of the quadriceps and biceps femoris muscles were used as the criteria of pain assessment in both groups. All measurements were taken before and after treatment. Results: Significant pain reduction: I (p = 0.00009, R = 0.68); II (p = 0.00002, R = 0.86), increased range of flexion in the knee: I (p = 0.000001, R = 0.90); II (p = 0.00002, R = 0.85), increased range of extension in the knee: I (p = 0.042, R = 0.87); II (p = 0.0004, R = 0.9) and increased strength of the quadriceps femoris muscle: I (p = 0.03, R = 0.77); II (p = 0.0002, R = 0.9) and the biceps femoris muscle: I (p = 0.04, R = 0.80); II (p = 0.0007, R = 0.91) were found in both groups after treatment. With the exception of flexion of the knee (p = 0.027; r = 0.17), there were no statistically significant differences in other analysed parameters between the use of laser alone and laser therapy combined with exercise. Conclusion: The use of laser in knee osteoarthritis reduces pain and improves the functional status of the patient. Laser therapy combined with kinesistherapy produces better therapeutic effects, and effectively improves the functional status of knee osteoarthritis. Exercise therapy applied in a series of 10 treatments is too short to significantly improve the functional status of the patient.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process

  7 / 92493 MEDLINE  
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[PMID]: 29504391
[Au] Autor:Li YJ; Yang CX; Yan XP
[Ad] Address:College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing , Nankai University , Tianjin 300071 , China.
[Ti] Title:Biomimetic Persistent Luminescent Nanoplatform for Autofluorescence-Free Metastasis Tracking and Chemophotodynamic Therapy.
[So] Source:Anal Chem;, 2018 Mar 09.
[Is] ISSN:1520-6882
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Metastasis is the main cause of death in people with cancer. Early diagnosis and targeted therapy for metastasis is crucial for the survival of the cancer patients. However, metastasis is hard to trace for its small size, dispersed distribution and unvascularized anatomy. Here we report a biomimetic persistent luminescent nanoplatform for noninvasive high-sensitive diagnosis and 808 nm laser controlled photodynamics assisted chemotherapy of metastasis. The nanoplatform is composed of a photosensitizer functionalized persistent luminescent nanoparticle core, a doxorubicin loaded hollow silica interlayer and a cancer cell membrane shell for effective metastasis theranostic. The cancer cell membrane shell prevents drug leakage and endows the nanoplatform with targeting ability to metastasis. The reactivatable persistent luminescence of persistent luminescent nanoparticles not only enables long-term in vivo metastasis tracking, but also provides internal light source for singlet oxygen generation to kill cancer cells and further break the membrane shell for drug release. This work provides a promising strategy to develop persistent luminescence imaging guided theranostic nanoplatforms for early metastasis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1021/acs.analchem.8b00311

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[PMID]: 29492713
[Au] Autor:Becorpi A; Campisciano G; Zanotta N; Tredici Z; Guaschino S; Petraglia F; Pieralli A; Sisti G; De Seta F; Comar M
[Ad] Address:Section of Gynecology and Obstetrics, Department of Woman and Child Health, Careggi University Hospital, Largo Brambilla 3, 50144, Florence, Italy.
[Ti] Title:Fractional CO laser for genitourinary syndrome of menopause in breast cancer survivors: clinical, immunological, and microbiological aspects.
[So] Source:Lasers Med Sci;, 2018 Mar 01.
[Is] ISSN:1435-604X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The composition of vaginal microbiome in menopause and cancer survivor women changes dramatically leading to genitourinary syndrome of menopause (GSM) in up to 70% of patients. Recent reports suggest that laser therapy may be valuable as a not hormonal therapeutic modality. The aim of the present study was to evaluate the effects of fractional CO laser treatment on the vaginal secretory pathway of a large panel of immune mediators, usually implicated in tissue remodeling and inflammation, and on microbiome composition in postmenopausal breast cancer survivors. The Ion Torrent PGM platform and the Luminex Bio-Plex platform were used for microbiome and immune factor analysis. The significant reduction of clinical symptoms and the non-significant changes in vaginal microbiome support the efficacy and safety of laser treatment. Moreover, the high remodeling status in vaginal epithelium is demonstrated by the significant changes in inflammatory and modulatory cytokine patterns. Laser therapy can be used for the treatment of GSM symptoms and does not show any adverse effects. However, further studies will be needed to clarify its long-term efficacy and other effects.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s10103-018-2471-3

  9 / 92493 MEDLINE  
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[PMID]: 29376616
[Au] Autor:Apolikhin OI; Moskvin SV
[Ad] Address:N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology branch of NMRRC of Minzdrav of Russia, Moscow, Russia.
[Ti] Title:[Laser therapy for mens infertility. Part 2. Systematic review of clinical trials].
[So] Source:Urologiia;(6):164-171, 2017 Dec.
[Is] ISSN:1728-2985
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Male infertility is a multifactorial syndrome associated with a wide range of pathological conditions affecting both the sexual and other body systems: endocrine, nervous, blood, and immune. Laser therapy is a form of modern physiotherapy that applies low-intensity laser irradiation (LILI) in various parts of the body. It is widely used in all areas of modern medicine due to its high efficiency, ease of use, the absence of contraindications and side effects. The authors reviewed the results of 171 studies investigating laser therapy, of which 93 were experimental (20 in Russian and 73 international publications), four clinical and experimental (all in Russian), 74 clinical (73 in Russian and 1 in English).Along with domestic literature, publications in Russian from Belarus, Georgia, Kyrgyzstan, Uzbekistan, and Ukraine were also reviewed. The review suggests that laser therapy should be used as much as possible in the management of male infertility not just due to high effectiveness, but also because of the lack of alternatives. For local application, optimal laser irradiation regimens are pulsed LILI of red (635 nm) and infrared (904 nm) spectra. For intravenous laser blood irradiation, the authors recommend alternating a continuous LILI with a wavelength of 635 nm (red spectrum) and 365 nm (ultraviolet spectrum).
[Mh] MeSH terms primary: Infertility, Male/radiotherapy
Low-Level Light Therapy/methods
[Mh] MeSH terms secundary: Clinical Trials as Topic
Humans
Infertility, Male/pathology
Infertility, Male/physiopathology
Male
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180130
[St] Status:MEDLINE

  10 / 92493 MEDLINE  
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[PMID]: 29376601
[Au] Autor:Orlov IN; Popov SV; Martov AG; Gallyamov EA; Malevich SM; Sushina IV; Grin EA; Sanzharov AE; Novikov AB; Sergeev VP; Kochkin AD
[Ad] Address:St. Lukes Clinical Hospital, St. Petersburg, Russia.
[Ti] Title:[Comparative assessment of treatments for prostate adenoma greater than 100 cm3].
[So] Source:Urologiia;(6):82-86, 2017 Dec.
[Is] ISSN:1728-2985
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:AIM: To compare holmium laser enucleation of the prostate (HoLEP) and endovideosurgical (EVS) adenomectomy in the treatment of prostate adenoma. MATERIALS AND METHODS: We compared treatment results of 180 patients with prostate adenomas greater than 100 cm3 who underwent EVS adenomectomy (n=90) and laser enucleation of the prostate (n=90). The analysis included the following parameters: duration of catheterization, length of postoperative hospital stay, I-PSS score, maximum urinary flow rate measured by uroflowmetry and complications according to Clavien-Dindo grading systems. RESULTS: There were no significant differences in patient age, preoperative prostate size, glandular tissue weight, and operative time. The duration of catheterization (p=0.0008) and length of postoperative hospital stay (p<0.0001) were significantly shorter in the HoLEP group. Both groups showed a statistically significant improvement in functional performance at three months post-surgery. Complications in the HoLEP and EVS adenomectomy group occurred in 18 (20%) and 23 (25.55%) patients, respectively (p>0.99). CONCLUSION: The two methods mentioned above are widely used in the treatment of prostate adenoma. However, holmium laser enucleation of the prostate shows similar short-term functional results and complication rates compared with EVS adenomectomy for prostate adenomas greater than 100 cm3. The patients of the HoLEP group had better results regarding the duration of catheterization and length of postoperative hospital stay. Therefore, laser enucleation is the preferred surgical modality for prostate adenomas greater than 100 cm3.
[Mh] MeSH terms primary: Laser Therapy/methods
Length of Stay
Prostate/surgery
Prostatic Hyperplasia/surgery
Video-Assisted Surgery/methods
[Mh] MeSH terms secundary: Aged
Humans
Male
Prostate/pathology
Prostatic Hyperplasia/pathology
[Pt] Publication type:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180130
[St] Status:MEDLINE


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