Database : MEDLINE
Search on : liposarcoma [Words]
References found : 6688 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 669 go to page                         

  1 / 6688 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29377717
[Au] Autor:Haller J; David MP; Lee NE; Shalin SC; Gardner JM
[Ti] Title:Impact of Pathologist Involvement in Sarcoma and Rare Tumor Patient Support Groups on Facebook: A Survey of 542 Patients and Family Members.
[So] Source:Arch Pathol Lab Med;, 2018 Jan 29.
[Is] ISSN:1543-2165
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CONTEXT: - Patients with rare tumors have difficulty finding reliable information about their disease. Facebook patient support groups allow patients to educate one another. OBJECTIVE: - To investigate how these patients perceive the value of pathologists, both in Facebook groups and real-world patient care. DESIGN: - Survey links were posted in 12 Facebook patient groups: 6 with an active pathologist member (angiosarcoma, epithelioid hemangioendothelioma, epithelioid sarcoma, dermatofibrosarcoma protuberans [×2], and desmoid fibromatosis), and 6 without "active" pathologist involvement (aggressive angiomyxoma, chondrosarcoma, Ewing sarcoma, leiomyosarcoma, liposarcoma, and osteosarcoma). RESULTS: - A total of 542 people responded (403 were patients): 264 from groups with a pathologist, and 278 from groups without active pathologist involvement. Of groups with an active pathologist, respondents agreed the pathologist's posts helped them better understand their disease (107 of 119; 90%) and relieved some of their disease-related anxiety (92 of 119; 77%). And for these groups 98% (117 of 119) of respondents agreed that having a pathologist in their group was a good thing; 83% (192 of 232) wanted more pathologists involved. More respondents from groups with an active pathologist (219 of 236; 93%) than without one (215 of 252; 85%) agreed: "pathologists are an important part of the patient care team for patients with cancer and other rare tumors" ( P = .008). CONCLUSIONS: - This study is the first to evaluate the impact of pathologist interaction with Facebook patient support groups and to assess perceptions about the specialty of pathology from a large group of patients with rare tumors. Pathologist involvement in Facebook patient groups appears to positively influence patient perception of the importance of pathologists. We hope these data will encourage more pathologists to participate in Facebook patient support groups.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.5858/arpa.2017-0408-OA

  2 / 6688 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29522292
[Au] Autor:Ando SM; Moreno RA; Viana PCC; Yamauchi FI
[Ad] Address:Departamento de Radiologia, Hospital das Clínicas da Universidade de São Paulo HC-FMUSP, São Paulo, Brasil.
[Ti] Title:Extensive renal sinus lipomatosis in xanthogranulomatous pyelonephritis simulating liposarcoma.
[So] Source:Int Braz J Urol;44, 2018 Mar 09.
[Is] ISSN:1677-6119
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Renal replacement lipomatosis is a condition characterized by varying degrees of renal parenchymal atrophy and perirenal fibrofatty proliferation secondary to chronic inflammation such as xanthogranulomatous pyelonephritis. In severe cases, imaging findings can be misdiagnosed as retroperitoneal liposarcoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1590/S1677-5538.IBJU.2017.0509

  3 / 6688 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29520652
[Au] Autor:Ikoma N; Roland CL; Torres KE; Chiang YJ; Wang WL; Somaiah N; Mann GN; Hunt KK; Cormier JN; Feig BW
[Ad] Address:Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
[Ti] Title:Salvage Surgery for Recurrent Retroperitoneal Well-Differentiated Liposarcoma: Early Reoperation may not Provide Benefit.
[So] Source:Ann Surg Oncol;, 2018 Mar 08.
[Is] ISSN:1534-4681
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Current evidence regarding salvage resection for recurrent retroperitoneal (RP) sarcomas generally lacks detailed histology-specific analyses, but the aggressiveness of these tumors varies widely by histology. We investigated associations between timing and extent of salvage surgery and survival outcomes in patients with recurrent RP well-differentiated liposarcoma (WDLPS). METHODS: The University of Texas MD Anderson Cancer Center Surgical Oncology sarcoma database was reviewed to identify patients with RP WDLPS who underwent surgical resection for first recurrent disease (salvage surgery) in 1995-2015. Medical records were retrospectively reviewed to identify factors associated with overall survival and disease-free survival. RESULTS: We identified 52 patients who underwent salvage surgery for RP WDLPS for first local recurrence; 28 (54%) underwent salvage surgery within 6 months after recurrence. Concomitant organ resections were performed in 32 (62%) patients, 4 (13%) of whom had pathologic invasion of resected organs. After R0/R1 resections (n = 45), 38 (84%) experienced a second local recurrence. Multivariable analyses revealed that organ invasion at the primary surgery [hazard ratio (HR) 13.08; p = 0.005] and disease-free interval < 1 year (HR 3.64; p = 0.044) were associated with shorter overall survival. Recurrence-to-salvage interval < 6 months was associated with shorter disease-free survival (HR 2.18; p = 0.025). Concomitant organ resection was associated with a longer hospital stay: ≥ 14 days (odds ratio 21.58; p = 0.007). CONCLUSIONS: Early salvage surgery may not always be the best approach for recurrent RP WDLPS patients. Because organ invasion is rare among recurrent RP WDLPS patients and concomitant organ resection is associated with a longer hospital stay, preservation of uninvolved organs should be considered.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1245/s10434-018-6417-6

  4 / 6688 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29203756
[Au] Autor:Kononenko M; Vynnychenko I; Moskalenko Y; Vynnychenko O
[Ad] Address:Department Of Surgery And Oncology, Sumy State University, Sumy, Ukraine.
[Ti] Title:12 years of fighting liposarcoma: a case report.
[So] Source:Wiad Lek;70(5):995-997, 2017.
[Is] ISSN:0043-5147
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:The proportion of liposarcoma in the structure of cancer incidence is from 10 to 35% of all mesenchymal tumors. This clinical observation describes an 12-year struggle with myxoid liposarcoma of the left upper arm, during which 17 surgeries were performed due to local recurrences, 17 radiation therapy courses and 5 chemotherapy courses were conducted. Clinical observation shows the whole complexity of myxoid liposarcoma treatment. The effectiveness of therapeutic management is determined by persistent surgery, and also by the lack of expression of Pgp, glutathione-S-transferase, metallothionein and mutant p53 in tumor structure.
[Mh] MeSH terms primary: Arm/pathology
Liposarcoma, Myxoid/therapy
Neoplasm Recurrence, Local/therapy
[Mh] MeSH terms secundary: Adult
Combined Modality Therapy
Humans
Liposarcoma, Myxoid/drug therapy
Liposarcoma, Myxoid/radiotherapy
Liposarcoma, Myxoid/surgery
Male
Neoplasm Recurrence, Local/drug therapy
Neoplasm Recurrence, Local/radiotherapy
Neoplasm Recurrence, Local/surgery
Neoplasm Staging
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171206
[St] Status:MEDLINE

  5 / 6688 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29517205
[Au] Autor:Harazin-Lechowska A; Ambroziak-Lackowska B; Rys J; Kruczak A; Gruchala A; Jaszcz-Gruchala A; Danda D; Przewoznik M; Halaszka K
[Ti] Title:The role of histology, grading, location of tumour and ploidy in evaluation of outcome in patients with liposarcoma.
[So] Source:Pol J Pathol;68(4):343-351, 2017.
[Is] ISSN:1233-9687
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Department of Tumour Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Kraków, Poland The review of literature indicates that several clinico-morphological factors such as location of the primary tumour as well as its size, histologic subtype, and grade or even selected molecular changes may significantly affect survival of liposarcoma (LPS) patients. Data concerning prognostic importance of DNA ploidy status in LPS cells are extremely limited and results of flow cytometry (FCM) studies have never been compiled with the current classification of malignant adipocytic tumours. Based on evaluation of material from 54 liposarcomas which was available for both histological and FCM analysis, we distinguished four prognostic groups of patients. The best prognosis was noticed for diploid and grade G1 well-differentiated or myxoid liposarcomas localised on extremities. None of the patients with lipoma-like WDLPS and myxoid liposarcoma grade 1 metastasised, while metastases were observed among patients with dedifferentiated LPS (70% of 5-year MFS) and cellular myxoid or round cell liposarcoma (20% of 5-year MFS, only). The metastasis-free survival curves for the above mentioned groups of patients differed significantly (p = 0.00001).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review

  6 / 6688 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29368794
[Au] Autor:Jing W; Lan T; Chen H; Zhang Z; Chen M; Peng R; He X; Zhang H
[Ad] Address:Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.
[Ti] Title:Amplification of FRS2 in atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma: a clinicopathological and genetic study of 146 cases.
[So] Source:Histopathology;, 2018 Jan 25.
[Is] ISSN:1365-2559
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:AIMS: The aim of this study was to evaluate the frequency of FRS2 amplification and its relationship with the clinicopathological features of atypical lipomatous tumour (ALT)/well-differentiated liposarcoma (WDL)/de-differentiated liposarcoma (DDL). METHODS AND RESULTS: FRS2 and MDM2 fluorescence in-situ hybridisation (FISH) was performed on 146 tumours (70 ALT/WDLs and 76 DDLs). One hundred and eight control samples were included for FRS2 analysis. FRS2 amplification was detected in 136 of 146 (93.2%) ALT/WDL/DDLs, including 63 ALT/WDLs and 73 DDLs. A higher FRS2/CEP12 ratio was observed in DDLs than in ALT/WDLs (P = 0.0005). The FRS2/CEP12 ratio of peripheral tumours was lower than that of central tumours (P = 0.00004). All the ALT/WDL/DDLs showed MDM2 amplification (100%). The MDM2 /FRS2 series included seven ALT/WDLs and three DDLs. Four of seven (57.1%) MDM2 /FRS2 ALT/WDLs occurred in peripheral sites, slightly higher than the percentage of MDM2 /FRS2 ALT/WDLs (28 of 63, 44.4%). All the three MDM2 /FRS2 DDLs (100%) were peripheral tumours, a much higher proportion than that of MDM2 /FRS2 DDLs (10 of 73, 13.7%). A high percentage of homologous pleomorphic liposarcoma-like DDLs (two of three) were observed in the MDM2 /FRS2 group. In the control group all the parosteal osteosarcomas (five of five, 100%) were FRS2 amplified, whereas the remaining 103 samples were FRS2 non-amplified. CONCLUSIONS: These findings suggest that FRS2 is amplified consistently in ALT/WDL/DDLs and offer another avenue for the investigation of the biology of this tumour group. MDM2 /FRS2 cases seem to be associated with certain clinicopathological features, and further investigation is needed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1111/his.13473

  7 / 6688 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29362359
[Au] Autor:Naumann M; Pal A; Goswami A; Lojewski X; Japtok J; Vehlow A; Naujock M; Günther R; Jin M; Stanslowsky N; Reinhardt P; Sterneckert J; Frickenhaus M; Pan-Montojo F; Storkebaum E; Poser I; Freischmidt A; Weishaupt JH; Holzmann K; Troost D; Ludolph AC; Boeckers TM; Liebau S; Petri S; Cordes N; Hyman AA; Wegner F; Grill SW; Weis J; Storch A; Hermann A
[Ad] Address:Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany.
[Ti] Title:Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.
[So] Source:Nat Commun;9(1):335, 2018 01 23.
[Is] ISSN:2041-1723
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS. Proper shuttling between the nucleus and cytoplasm is essential for physiological cell function. However, the initial event in the pathophysiology of FUS-ALS remains enigmatic. Using human induced pluripotent stem cell (hiPSCs)-derived motor neurons (MNs), we show that impairment of poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response (DDR) signaling due to mutations in the FUS nuclear localization sequence (NLS) induces additional cytoplasmic FUS mislocalization which in turn results in neurodegeneration and FUS aggregate formation. Our work suggests that a key pathophysiologic event in ALS is upstream of aggregate formation. Targeting DDR signaling could lead to novel therapeutic routes for ameliorating ALS.
[Mh] MeSH terms primary: Amyotrophic Lateral Sclerosis/metabolism
DNA Damage
Motor Neurons/metabolism
Mutation
Protein Aggregation, Pathological/metabolism
RNA-Binding Protein FUS/metabolism
[Mh] MeSH terms secundary: Active Transport, Cell Nucleus/genetics
Aged
Aged, 80 and over
Amyotrophic Lateral Sclerosis/genetics
Amyotrophic Lateral Sclerosis/pathology
Cell Differentiation
Cell Nucleus/metabolism
Cytoplasm/metabolism
Female
Gene Expression
Humans
Induced Pluripotent Stem Cells/metabolism
Induced Pluripotent Stem Cells/pathology
Male
Middle Aged
Motor Neurons/pathology
Nuclear Localization Signals/genetics
Nuclear Localization Signals/metabolism
Poly (ADP-Ribose) Polymerase-1/genetics
Poly (ADP-Ribose) Polymerase-1/metabolism
Protein Aggregation, Pathological/genetics
Protein Aggregation, Pathological/pathology
RNA-Binding Protein FUS/genetics
Signal Transduction
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Nuclear Localization Signals); 0 (RNA-Binding Protein FUS); EC 2.4.2.30 (PARP1 protein, human); EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1)
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:180125
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02299-1

  8 / 6688 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29503824
[Au] Autor:Cannavale G; Francone M; Galea N; Vullo F; Molisso A; Carbone I; Catalano C
[Ad] Address:Department of Radiological, Oncological and Anatomo-Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
[Ti] Title:Fatty Images of the Heart: Spectrum of Normal and Pathological Findings by Computed Tomography and Cardiac Magnetic Resonance Imaging.
[So] Source:Biomed Res Int;2018:5610347, 2018.
[Is] ISSN:2314-6141
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Ectopic cardiac fatty images are not rarely detected incidentally by computed tomography and cardiac magnetic resonance, or by exams focused on the heart as in general thoracic imaging evaluations. A correct interpretation of these findings is essential in order to recognize their normal or pathological meaning, focusing on the eventually associated clinical implications. The development of techniques such as computed tomography and cardiac magnetic resonance allowed a detailed detection and evaluation of adipose tissue within the heart. This pictorial review illustrates the most common characteristics of cardiac fatty images by computed tomography and cardiac magnetic resonance, in a spectrum of normal and pathological conditions ranging from physiological adipose images to diseases presenting with cardiac fatty foci. Physiologic intramyocardial adipose tissue may normally be present in healthy adults, being not related to cardiac affections and without any clinical consequence. However cardiac fatty images may also be the expression of various diseases, comprehending arrhythmogenic right ventricular dysplasia, postmyocardial infarction lipomatous metaplasia, dilated cardiomyopathy, and lipomatous hypertrophy of the interatrial septum. Fatty neoplasms of the heart as lipoma and liposarcoma are also described.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1155/2018/5610347

  9 / 6688 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29429160
[Au] Autor:Zhao M; Wang YB; Yan YJ; Wang W; Ru GQ; He XL
[Ad] Address:Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
[Ti] Title:[Clinicopathologic features of atypical spindle cell lipomatous tumor].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(2):99-104, 2018 Feb 08.
[Is] ISSN:0529-5807
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To investigate the clinicopathologic characteristics, immunophenotype, differential and diagnostic features of atypical spindle cell lipomatous tumor (ASLT). Three cases of ASLT were collected from January 2010 to March 2017 at Zhejiang Provincial People's Hospital. The clinical and imaging features, histomorphology, immunophenotype and prognosis were analyzed. Fluorescence in situ hybridization (FISH) was used to detect MDM2 gene amplification, and relevant literature was reviewed. All three patients were adult males, aged 38, 43 and 54 years, respectively. One tumor originated in the subcutaneous soft tissue in the head and neck, one was located in the left primary bronchus and one in the latissimus dorsi muscle. Grossly, all three tumors were circumscribed and ranged from 4.0 to 5.8 cm in size. Microscopically, all showed a focally infiltrative front. These tumors were composed of variable proportions of spindle-shaped and adipocytic cells in a background of variable fibrous and edematous matrix. Scattered lipoblasts were easily seen. One tumor was composed predominately of spindle tumor cells, one of adipocytic cells, and one of equally mixed cell populations. The spindle tumor cells were generally bland-appearing with focal nuclear enlargement and hyperchromasia noted in one case. Mitosis was not seen in neither the spindle cells nor the adipocytic cells. By immunohistochemistry, diffuse and strong reactivity to CD34 of the spindle cells was noted in all cases, definite loss of Rb expression was noted in one of three cases, and S-100 protein was expressed only in the adipocytic cells. INI-1 was intact and Ki-67 index was 1% to 3%. All other markers including CDK4, MDM2, STAT6, SOX10, CD99, bcl-2, ß-catenin, CD117, GFAP, CK, EMA, SMA and desmin were negative. FISH of MDM2 was done in two cases, and both showed no amplification. The ASLT in the head and neck had two recurrences during 17 months of follow-up, whereas the tumor in the latissimus dorsi was free of disease during 33 months of follow-up. ASLT is a rare subtype of low-grade adipocytic neoplasm and is distinctive from atypical lipomatous tumor/well-differentiated liposarcoma. The histomorpholgy of ASLT has significant heterogeneity and forms a continuous spectrum. ASLT needs to be distinguished from a series of benign and malignant soft tissue tumors.
[Mh] MeSH terms primary: Bronchial Neoplasms/pathology
Head and Neck Neoplasms/pathology
Lipoma/pathology
Muscle Neoplasms/pathology
[Mh] MeSH terms secundary: Adult
Bronchial Neoplasms/chemistry
Head and Neck Neoplasms/chemistry
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lipoma/chemistry
Liposarcoma/chemistry
Liposarcoma/pathology
Male
Middle Aged
Muscle Neoplasms/chemistry
Neoplasm Recurrence, Local
S100 Proteins/analysis
STAT6 Transcription Factor/analysis
Superficial Back Muscles
beta Catenin/analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (CTNNB1 protein, human); 0 (S100 Proteins); 0 (STAT6 Transcription Factor); 0 (STAT6 protein, human); 0 (beta Catenin)
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.02.004

  10 / 6688 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29429159
[Au] Autor:Liu L; Wang LH; Ren YB; Rao XS; Yang SM
[Ad] Address:Department of Pathology, Peking University International Hospital, Beijing 102206, China.
[Ti] Title:[Retroperitoneal dedifferentiated liposarcoma with rhabdomyoblastic differentiation: a clinicopathological analysis].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(2):94-98, 2018 Feb 08.
[Is] ISSN:0529-5807
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To investigate the clinicopathological features, differential diagnosis, treatment and prognosis of dedifferentiated liposarcoma with rhabdomyoblastic differentiation. Six cases of retroperitoneal dedifferentiated liposarcoma with rhabdomyoblastic features were collected from December 2014 to August 2017 at Peking University International Hospital. The clinical manifestations, histomorphology, immunophenotype, treatment and follow-up data were analyzed, and relevant literature reviewed. The six patients included two males and four females, with age range of 47 to 66 years (mean 56 years). One case was primary and the five cases were recurred; four cases received radiotherapy and/or chemotherapy. The tumor diameters were 10 to 30 cm. Microscopically, the dedifferentiated areas were well demarcated from the well-differentiated areas, and resembled malignant fibrous histiocytoma, fibrosarcoma or solitary fibrous tumor with obvious mitotic figures or necrosis. Rhabdomyoblastic cells made up 10% to 30% of dedifferentiated area, and were scattered or focally distributed, being rounded, band-like or spindled, mostly with abundant eosinophilic cytoplasm. No striated structure was found, and the nucleis were rounded, oval or irregular shape with central or eccentric prominent nucleoli. Rare rhabdomyoblastic cells were lymphocytoid. The tumors encroached the muscular layer of intestinal wall in two cases and perirenal adipose tissue in one case. By immunohistochemical staining, the rhabdomyoblastic cells of all cases were all positive for desmin, myogenin, myoD1 and SMA; S-100 protein was expressed in one case (1/6). Well-differentiated area in two cases and dedifferentiated areas in all six cases were positive for MDM2, CDK4 and p16. After resection of the tumor and adjacent organs, one case recurred three months later, but there was no distant metastasis. Dedifferentiated liposarcoma with rhabdomyoblastic differentiation is a rare dedifferentiated liposarcoma. Pathological diagnosis is based on morphology, with supplementary immunohistochemical or molecular evaluation for further differential diagnosis. Multiple relapses may occur after surgical ablation plus adjuvant therapy.
[Mh] MeSH terms primary: Liposarcoma/pathology
Retroperitoneal Neoplasms/pathology
[Mh] MeSH terms secundary: Aged
Cell Count
Cell Differentiation
Diagnosis, Differential
Female
Fibrosarcoma/pathology
Histiocytoma, Malignant Fibrous/pathology
Humans
Immunophenotyping
Liposarcoma/therapy
Male
Middle Aged
Neoplasm Recurrence, Local
Prognosis
Retroperitoneal Neoplasms/therapy
Solitary Fibrous Tumors/pathology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.02.003


page 1 of 669 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information