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Search on : lymphangiosarcoma [Words]
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[PMID]: 29068520
[Au] Autor:Miyagawa T; Kadono T; Saigusa R; Yamada D; Masui Y; Fujita H; Asano Y; Sato S
[Ad] Address:Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
[Ti] Title:Lymphangiosarcoma of the hip arising in a congenital non-irradiated lymphangioma.
[So] Source:J Dtsch Dermatol Ges;, 2017 Oct 25.
[Is] ISSN:1610-0387
[Cp] Country of publication:Germany
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1710
[Cu] Class update date: 171025
[Lr] Last revision date:171025
[St] Status:Publisher
[do] DOI:10.1111/ddg.13356

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[PMID]: 29035997
[Au] Autor:Brittain JM; Nymark T; Hildebrandt MG; Hovgaard D; Andersen KF
[Ad] Address:From the *Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, Copenhagen; †Department of Orthopedic Surgery, Odense University Hospital, University of Southern Denmark, Odense; ‡Musculoskeletal Tumor Section, Department of Orthopedic Surgery, Rigshospitalet, University of Copenhagen, Copenhagen; and §Department of Nuclear Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
[Ti] Title:Stewart-Treves Syndrome on the Lower Extremity Associated to Idiopathic Chronic Lymphedema Visualized on FDG PET/CT.
[So] Source:Clin Nucl Med;42(12):e519-e522, 2017 Dec.
[Is] ISSN:1536-0229
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Angiosarcomas are highly malignant and rare tumors of vascular or lymphatic endothelial cell origin with a poor prognosis. Lymphangiosarcoma associated with chronic lymphedema is known as Stewart-Treves syndrome. Stewart-Treves syndrome is primarily described in patients with lymphedema of an upper extremity occurring after breast cancer surgery including radical axillary lymph node dissection and subsequent radiotherapy. It is rarely described in the presence of idiopathic chronic lymphedema of the lower extremities. We present a case of lymphangiosarcoma visualized on F-FDG PET/CT, where Stewart-Treves syndrome is secondary to probably a combination of idiopathic chronic lymphedema of the lower extremities and systemic immunosuppressive treatment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:In-Process
[do] DOI:10.1097/RLU.0000000000001856

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[PMID]: 28762232
[Au] Autor:Díaz-Flores L; Gutiérrez R; García-Suárez MP; Sáez FJ; Gutiérrez E; Valladares F; Carrasco JL; Díaz-Flores L; Madrid JF
[Ad] Address:Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, Tenerife, Spain. kayto54@gmail.com.
[Ti] Title:Morphofunctional basis of the different types of angiogenesis and formation of postnatal angiogenesis-related secondary structures.
[So] Source:Histol Histopathol;32(12):1239-1279, 2017 Dec.
[Is] ISSN:1699-5848
[Cp] Country of publication:Spain
[La] Language:eng
[Ab] Abstract:We review the morpho-functional basis of the different types of angiogenesis and report our observations, including the formation of angiogenesis-related secondary structures. First of all, we consider the following issues: a) conceptual differences between angiogenesis and vasculogenesis, b) incidence of angiogenesis in pre- and postnatal life, c) regions of vascular tree with angiogenic capacity, d) cells (endothelial cells, pericytes, CD34+ adventitial stromal cells of the microvasculature and inflammatory cells) and extracellular matrix components involved in angiogenesis, e) events associated with angiogenesis, f) different types of angiogenesis, including sprouting and intussusceptive angiogenesis, and other angiogenic or vascularization forms arising from endothelial precursor cells (postnatal vasculogenesis), vasculogenesis mimicry, vessel co-option and piecemeal angiogenesis. Subsequently, we consider the specific morpho-functional characteristics of each type of angiogenesis. In sprouting angiogenesis, we grouped the events in three phases: a) activation phase, which includes vasodilation and increased permeability, EC, pericyte and CD34+ adventitial stromal cell activation, and recruitment and activation of inflammatory cells, b) sprouting phase, encompassing EC migration (concept and characteristics of endothelial tip cells, tip cell selection, lateral inhibition, localized filopodia formation, basal lamina degradation and extracellular changes facilitating EC migration), EC proliferation (concept of endothelial stalk cells), pericyte mobilization, proliferation, recruitment and changes in CD34+ adventitial stromal cells and inflammatory cells, tubulogenesis, formation of a new basal lamina, and vascular anastomosis with capillary loop formation, and c) vascular remodelling and stabilization phase (concept of phalanx cells). Subsequently, the concept, incidence, events and mechanisms are considered in the other forms of angiogenesis. Finally, we contribute the formation of postnatal angiogenesis-related secondary structures: a) intravascular structures through piecemeal angiogenesis, including intravascular papillae in vessel tumours and pseudotumours (intravascular papillary endothelial hyperplasia, vascular transformation of the sinus in lymph nodes, papillary intralymphatic angioendothelioma or Dabska tumour, retiform hemangioendothelioma, hemangiosarcoma and lymphangiosarcoma), vascular septa in hemorrhoidal veins and intravascular projections in some tumours; b) arterial intimal thickening; c) intravascular tumours and pseudotumours (e.g. intravenous pyogenic granulomas and intravascular myopericytoma); d) vascular glomeruloid proliferations; and e) pseudopalisading necrosis in glioblastoma multiform.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1708
[Cu] Class update date: 171027
[Lr] Last revision date:171027
[St] Status:In-Process
[do] DOI:10.14670/HH-11-923

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[PMID]: 28538886
[Au] Autor:Cabral ANF; Rocha RH; Amaral ACVD; Medeiros KB; Nogueira PSE; Diniz LM
[Ad] Address:Hospital Universitário Cassiano Antônio Moraes, da Universidade Federal do Espírito Santo (Hucam-Ufes) - Vitória (ES), Brazil.
[Ti] Title:Cutaneous angiosarcoma: report of three different and typical cases admitted in a unique dermatology clinic.
[So] Source:An Bras Dermatol;92(2):235-238, 2017 Mar-Apr.
[Is] ISSN:1806-4841
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Angiosarcoma is a rare and aggressive tumor with high rates of metastasis and relapse. It shows a particular predilection for the skin and superficial soft tissues. We report three distinct and typical cases of angiosarcoma that were diagnosed in a single dermatology clinic over the course of less than a year: i) Angiosarcoma in lower limb affected by chronic lymphedema, featuring Stewart-Treves syndrome; ii) a case of the most common type of angiosarcoma loated in the scalp and face of elderly man and; iii) a skin Angiosarcoma in previously irradiated breast. All lesions presented characteristic histopathological findings: irregular vascular proliferation that dissects the collagen bundles with atypical endothelial nuclei projection toward the lumen.
[Mh] MeSH terms primary: Head and Neck Neoplasms/pathology
Hemangiosarcoma/pathology
Scalp/pathology
Skin Neoplasms/pathology
[Mh] MeSH terms secundary: Adult
Aged, 80 and over
Breast/pathology
Female
Humans
Leg/pathology
Lymphangiosarcoma
Lymphedema/complications
Male
Middle Aged
Risk Factors
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1710
[Cu] Class update date: 171006
[Lr] Last revision date:171006
[Js] Journal subset:IM
[Da] Date of entry for processing:170525
[St] Status:MEDLINE

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[PMID]: 28263114
[Au] Autor:Lin D; Jennings SH
[Ti] Title:Pathology in Practice. Ventral abdominal lymphangiosarcoma.
[So] Source:J Am Vet Med Assoc;250(6):623-626, 2017 03 15.
[Is] ISSN:1943-569X
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 171004
[Lr] Last revision date:171004
[St] Status:In-Process
[do] DOI:10.2460/javma.250.6.623

  6 / 395 MEDLINE  
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[PMID]: 27795793
[Au] Autor:Krich S; Mernissi FZ
[Ad] Address:Service de Dermatologie-Vénérologie, Centre Hospitalier Universitaire Hassan II, Fès, Maroc.
[Ti] Title:Syndrome de Stewart-Treves: complication rare de lymphÅ“dème chronique. [Stewart-Treves syndrome: a rare complication of chronic lymphedema].
[So] Source:Pan Afr Med J;24:196, 2016.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:fre
[Mh] MeSH terms primary: Hemangiosarcoma/diagnosis
Lymphangiosarcoma/diagnosis
Lymphedema/complications
[Mh] MeSH terms secundary: Adult
Diagnosis, Differential
Fatal Outcome
Hemangiosarcoma/etiology
Hemangiosarcoma/therapy
Humans
Lower Extremity/pathology
Lymphangiosarcoma/etiology
Lymphangiosarcoma/therapy
Lymphedema/diagnosis
Male
Palliative Care/methods
Prognosis
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1702
[Cu] Class update date: 170227
[Lr] Last revision date:170227
[Js] Journal subset:IM
[Da] Date of entry for processing:161101
[St] Status:MEDLINE

  7 / 395 MEDLINE  
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[PMID]: 27780597
[Au] Autor:Udager AM; Ishikawa MK; Lucas DR; McHugh JB; Patel RM
[Ad] Address:Department of Pathology, University of Michigan Health System, Ann Arbor, MI, United States.
[Ti] Title:MYC immunohistochemistry in angiosarcoma and atypical vascular lesions: practical considerations based on a single institutional experience.
[So] Source:Pathology;48(7):697-704, 2016 Dec.
[Is] ISSN:1465-3931
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Angiosarcoma (AS) is an uncommon vascular malignancy with an aggressive clinical course. Radiation-associated angiosarcoma (RAAS) and Stewart-Treves syndrome are associated with MYC gene amplification and protein overexpression, while other radiation-associated vascular lesions including atypical vascular lesions (AVL) are not associated with MYC overexpression. In contrast, de novo AS represent a group of molecularly heterogeneous tumours, for which MYC expression has not been extensively examined. In this study, MYC immunohistochemistry (IHC) was performed on representative whole tissue sections of a large retrospective cohort of de novo AS, RAAS, Stewart-Treves syndrome, and AVL and evaluated using a semi-quantitative scoring method. MYC is strongly expressed in the majority of RAAS and Stewart-Treves syndrome. De novo AS demonstrate variable MYC expression, with high-grade tumours showing significantly higher MYC expression than low-grade tumours. In contrast, MYC expression in AVL is predominantly negative but may occasionally show focal staining. These results indicate that unequivocal strong MYC IHC staining supports the diagnosis of RAAS. In rare cases of RAAS without strong MYC expression, however, particularly relatively low-grade tumours for which the differential diagnosis includes AVL, the distinction between these lesions should be made on morphological grounds using previously established criteria (i.e., significant atypia, deep invasion, infiltrative growth, etc.). Increased MYC expression in high-grade de novo AS suggests that MYC overexpression may play a role in the pathogenesis of these tumours, and MYC IHC may be a prognostic and/or therapeutic biomarker in a subset of these tumours.
[Mh] MeSH terms primary: Biomarkers, Tumor/analysis
Hemangiosarcoma/diagnosis
Lymphangiosarcoma/diagnosis
Neoplasms, Radiation-Induced/diagnosis
Proto-Oncogene Proteins c-myc/biosynthesis
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Female
Humans
Immunohistochemistry
Male
Middle Aged
Proto-Oncogene Proteins c-myc/analysis
Retrospective Studies
Tissue Array Analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers, Tumor); 0 (MYC protein, human); 0 (Proto-Oncogene Proteins c-myc)
[Em] Entry month:1703
[Cu] Class update date: 170330
[Lr] Last revision date:170330
[Js] Journal subset:IM
[Da] Date of entry for processing:161027
[St] Status:MEDLINE

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[PMID]: 27766300
[Au] Autor:Whitney K; Schapiro B; LaFond AA
[Ad] Address:Department of Dermatology, St Joseph Mercy Hospital, Ann Arbor, Michigan.
[Ti] Title:An unusual presentation of Stewart-Treves syndrome on the lower extremity.
[So] Source:JAAD Case Rep;2(5):397-399, 2016 Sep.
[Is] ISSN:2352-5126
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE

  9 / 395 MEDLINE  
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[PMID]: 27537557
[Au] Autor:Sasajima J; Uehara J; Goto T; Fujibayashi S; Koizumi K; Mizukami Y; Ishida-Yamamoto A; Fujiya M; Okumura T
[Ad] Address:aDivision of Gastroenterology and Hematology/Oncology, Department of Medicine bDepartment of Dermatology, Asahikawa Medical University, Hokkaido cGastroenterology Medicine Center, Shonan Kamakura General Hospital, Kanagawa dCenter for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.
[Ti] Title:Pancreatic metastasis of angiosarcoma (Stewart-Treves syndrome) diagnosed using endoscopic ultrasound-guided fine needle aspiration: A case report.
[So] Source:Medicine (Baltimore);95(33):e4316, 2016 Aug.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Pancreatic involvement of angiosarcoma is extremely rare. METHODS: We herein report a rare case of angiosarcoma associated with chronic lymphedema (Stewart-Treves syndrome) with pancreatic metastasis that was diagnosed using endoscopic ultrasound (EUS)/fine needle aspiration (FNA). RESULTS: A 43-year-old woman with a history of radical hysterectomy with bilateral inguinal lymphadenectomy and chemoradiotherapy for cervical cancer 15 years prior noticed the presence of erythematous indurative plaques on her right femoral region, where chronic lymphedema had developed. Contrast-enhanced computed tomography (CT) revealed not only multiple nodules in the subcutaneous tissue of the right femoral region but also a 25 mm × 20 mm solid mass in the region of the pancreatic tail. A histological analysis of the specimens obtained using EUS/FNA revealed angiosarcoma that was immunohistochemically positive for platelet/endothelial cell adhesion molecule-1 but negative for cytokeratin. The patient was diagnosed as Stewart-Treves syndrome that had metastasized to the pancreas. Chemotherapy was performed, but the patient died 14 months after her diagnosis. CONCLUSION: Unfortunately, this patient was not followed up, even though she had chronic lymphedema of the right femoral region due to the repeated occurrence of phlegmon. To improve the survival rate of this fatal secondary malignant complication of radical lymphadenectomy, an early diagnosis with consecutive and long-term clinical follow-up and close monitoring for Stewart-Treves syndrome is therefore important.
[Mh] MeSH terms primary: Hemangiosarcoma/diagnosis
Lymphangiosarcoma/diagnosis
Pancreatic Neoplasms/secondary
[Mh] MeSH terms secundary: Adult
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Female
Hemangiosarcoma/pathology
Humans
Lymphangiosarcoma/pathology
Pancreas/diagnostic imaging
Pancreas/pathology
Pancreatic Neoplasms/diagnostic imaging
Tomography, X-Ray Computed
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1702
[Cu] Class update date: 170403
[Lr] Last revision date:170403
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:160819
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004316

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[PMID]: 27318054
[Au] Autor:Joh JH; Lee BB; Chun YS; Chung WK; Lee HY
[Ad] Address:Department of Surgery, Kyung Hee University School of Medicine, Seoul, Korea. Electronic address: jhjoh@khu.ac.kr.
[Ti] Title:Angiosarcoma after excisional surgery for chronic lymphedema.
[So] Source:J Vasc Surg Venous Lymphat Disord;4(3):336-9, 2016 Jul.
[Is] ISSN:2213-3348
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Angiosarcoma is a rare soft tissue sarcoma of endothelial cell origin. It can arise from the endothelium of lymphatics (lymphangiosarcoma) or blood vessels (hemangiosarcoma). Chronic lymphedema of any origin is associated with its development. Few cases have been reported after surgical procedures for lymphedema. Here, we report one case of angiosarcoma that developed 15 months after excisional surgery for lymphedema. In spite of radical surgery and adjuvant chemoradiotherapy, the patient died of multiple lung metastases and pleural effusion 13 months later.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 171016
[Lr] Last revision date:171016
[Js] Journal subset:IM
[St] Status:In-Process


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