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Search on : malignant and atrophic and papulosis [Words]
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[PMID]: 29516548
[Au] Autor:Hu P; Mao Z; Liu C; Hu X; Kang H; Zhou F
[Ad] Address:Department of Critical Care Medicine, Chinese People's Liberation Army General Hospital, Beijing, China.
[Ti] Title:Malignant atrophic papulosis with motor aphasia and intestinal perforation: A case report and review of published works.
[So] Source:J Dermatol;, 2018 Mar 08.
[Is] ISSN:1346-8138
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Malignant atrophic papulosis (MAP) is a rare type of obliterating vasculopathy that can present as pure cutaneous lesions or a systemic entity affecting multiple organs. Systemic disease, such as gastrointestinal or central nervous system involvement, may predispose the patients to poorer or even fatal outcomes. We present a 30-year-old female patient with systemic manifestation of MAP 10 days after delivery of a full-term pregnancy who subsequently developed motor aphasia and intestinal perforation. The patient was administrated empirical treatment with an antiplatelet, anticoagulant, methylprednisolone sodium succinate and alprostadil. Antibiotics were administrated due to intestinal perforation and secondary sepsis. Despite all treatment, the patient died a week later. We summarized all the previous reports of MAP based on thorough review of previous published work. Overall, this is the first patient with MAP combined with motor aphasia and intestinal perforation and may provide insights for future studies on the treatment of this disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1111/1346-8138.14280

  2 / 215 MEDLINE  
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[PMID]: 29239824
[Au] Autor:Ye L; Lekgabe E; Tsui A; Gaillard F
[Ad] Address:Department of Radiology, the Royal Melbourne Hospital, Parkville, VIC, Australia. Electronic address: louie.ye@mh.org.au.
[Ti] Title:The evolution of cerebrovascular changes in Köhlmeier-Degos disease: An 11-year follow-up case report.
[So] Source:J Clin Neurosci;48:114-117, 2018 Feb.
[Is] ISSN:1532-2653
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:Köhlmeier-Degos disease is rare idiopathic vasculopathy, the exact pathogenesis of which remains unclear. Here, we review pertinent literatutre and present a case of a Köhlmeier-Degos disease with central nervous system involvement followed-up over 11 years with various neuroimaging modalities. Evolution of neurovascular and neuropathological changes over an extended time period has not been previously described.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180109
[Lr] Last revision date:180109
[St] Status:In-Process

  3 / 215 MEDLINE  
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[PMID]: 28691162
[Au] Autor:Wallace MP; Thomas JM; Meligonis G; Ha T
[Ad] Address:Department of Dermatology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.
[Ti] Title:Systemic lupus erythematosus, following prodromal idiopathic thrombocytopenic purpura, presenting with skin lesions resembling malignant atrophic papulosis.
[So] Source:Clin Exp Dermatol;42(7):774-776, 2017 Oct.
[Is] ISSN:1365-2230
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Systemic lupus erythematosus (SLE) is an autoimmune disease. Its incidence in the UK is approximately 1 per 10 000. Cutaneous involvement, encompassing acute, subacute and chronic disease, occurs in over two-thirds of cases, and can often be the first clue to diagnosis. We describe a highly unusual case of SLE occurring after prodromal idiopathic thrombocytopenic purpura (ITP) and presenting with skin lesions more typical of malignant atrophic papulosis, a rare and often fatal vasculopathy. Such a combination of rare features emphasizes the potential for complexity in this multisystem disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170919
[Lr] Last revision date:170919
[St] Status:In-Process
[do] DOI:10.1111/ced.13158

  4 / 215 MEDLINE  
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[PMID]: 28544089
[Au] Autor:Zouboulis CC; Theodoridis A; Brunner M; Magro CM
[Ad] Address:Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Theodore Fontane Medical University of Brandenburg, Dessau, Germany.
[Ti] Title:Benign atrophic papulosis (Köhlmeier-Degos disease): the wedge-shaped dermal necrosis can resolve with time.
[So] Source:J Eur Acad Dermatol Venereol;31(10):1753-1756, 2017 Oct.
[Is] ISSN:1468-3083
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Atrophic papulosis is a rare thrombo-occlusive disease, characterized by the appearance of multiple atrophic porcelain-white skin papules, with a surrounding erythematous rim, which are histologically consisting of wedge-shaped necrosis of the dermis. OBJECTIVE: It consists of two variants: (i) the benign atrophic papulosis (BAP) only involving the skin and (ii) the malignant atrophic papulosis (MAP) also involving several internal organs with a cumulative five-year survival rate of approx. 55%. While the probability of only having a BAP at onset is approximately 70%, increasing to 97% after 7 years of monosymptomatic cutaneous course, no close long-term follow-up of the development of the skin lesions has been reported. METHODS: We present a precise visual documentation of the evolution of the disseminated skin lesions in a female patient with BAP spanning over two decades. RESULTS: A considerable improvement and/or clinical resolution of the majority of the lesions disputing the scarring character of the atrophic porcelain-white skin papules has been detected. CONCLUSION: BAP not only exhibits an excellent prognosis, but resolution of lesions can also occur after a considerable period of time.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[St] Status:In-Process
[do] DOI:10.1111/jdv.14355

  5 / 215 MEDLINE  
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[PMID]: 28392651
[Au] Autor:Jang MS; Park JB; Yang MH; Jang JY; Kim JH; Lee KH; Kim GT; Hwangbo H; Suh KS
[Ad] Address:Department of Dermatology, Kosin University College of Medicine, Busan, Korea.
[Ti] Title:Degos-Like Lesions Associated with Systemic Lupus Erythematosus.
[So] Source:Ann Dermatol;29(2):215-218, 2017 Apr.
[Is] ISSN:1013-9087
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Degos disease, also referred to as malignant atrophic papulosis, was first described in 1941 by Köhlmeier and was independently described by Degos in 1942. Degos disease is characterized by diffuse, papular skin eruptions with porcelain-white centers and slightly raised erythematous telangiectatic rims associated with bowel infarction. Although the etiology of Degos disease is unknown, autoimmune diseases, coagulation disorders, and vasculitis have all been considered as underlying pathogenic mechanisms. Approximately 15% of Degos disease have a benign course limited to the skin and no history of gastrointestinal or central nervous system (CNS) involvement. A 29-year-old female with history of systemic lupus erythematosus (SLE) presented with a 2-year history of asymptomatic lesions on the dorsum of all fingers and both knees. The patient had only skin lesions and no gastrointestinal or CNS vasculitis symptoms. Her skin lesions were umbilicated, atrophic porcelain-white lesions with a rim of erythema. On the basis of clinical, histologic, and laboratory findings, a diagnosis of Degos-like lesions associated with SLE was made. The patient had been treated for SLE for 7 years. Her treatment regimen was maintained over a 2 month follow-up period, and the skin lesions improved slightly with no development of new lesions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170413
[Lr] Last revision date:170413
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5021/ad.2017.29.2.215

  6 / 215 MEDLINE  
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[PMID]: 28244939
[Au] Autor:Kim E; Motaparthi K
[Ad] Address:*Department of Dermatology, University of Central Florida College of Medicine, Orlando, FL; and †Department of Dermatology, University of Florida College of Medicine, Gainesville, FL.
[Ti] Title:Benign Atrophic Papulosis (Degos Disease) With Lymphocytic Vasculitis and Lichen Sclerosus-Like Features.
[So] Source:Am J Dermatopathol;, 2017 Feb 14.
[Is] ISSN:1533-0311
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Degos disease manifests as 2 distinct clinical variants, malignant atrophic papulosis and benign atrophic papulosis, which are distinguished by the presence or absence of systemic disease. Both forms feature cutaneous involvement typified by erythematous papules with scar-like centers, and the classic histologic picture is described as wedge-shaped dermal necrosis overlying thrombotic vasculopathy. However, the histopathology of early lesions is distinct and more variable. A case of benign atrophic papulosis with lymphocytic vasculitis and lichen sclerosus-like features is described, and the spectrum of histologic findings in Degos disease is reviewed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 170228
[Lr] Last revision date:170228
[St] Status:Publisher
[do] DOI:10.1097/DAD.0000000000000847

  7 / 215 MEDLINE  
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[PMID]: 27717619
[Au] Autor:Oliver B; Boehm M; Rosing DR; Shapiro LS; Dempsey DT; Merkel PA; Lee CR; Cowen EW
[Ad] Address:National Institutes of Health, Bethesda, Maryland.
[Ti] Title:Diffuse atrophic papules and plaques, intermittent abdominal pain, paresthesias, and cardiac abnormalities in a 55-year-old woman.
[So] Source:J Am Acad Dermatol;75(6):1274-1277, 2016 Dec.
[Is] ISSN:1097-6787
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:KEY TEACHING POINTS.
[Mh] MeSH terms primary: Antibodies, Monoclonal, Humanized/therapeutic use
Malignant Atrophic Papulosis/diagnosis
Malignant Atrophic Papulosis/drug therapy
[Mh] MeSH terms secundary: Abdominal Pain/etiology
Anti-Arrhythmia Agents/therapeutic use
Atrial Fibrillation/drug therapy
Atrial Fibrillation/etiology
Factor Xa Inhibitors/therapeutic use
Female
Humans
Malignant Atrophic Papulosis/complications
Metoprolol/therapeutic use
Middle Aged
Paresthesia/etiology
Pyrazoles/therapeutic use
Pyridones/therapeutic use
Tricuspid Valve Insufficiency/etiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Arrhythmia Agents); 0 (Antibodies, Monoclonal, Humanized); 0 (Factor Xa Inhibitors); 0 (Pyrazoles); 0 (Pyridones); 3Z9Y7UWC1J (apixaban); A3ULP0F556 (eculizumab); GEB06NHM23 (Metoprolol)
[Em] Entry month:1704
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:161009
[St] Status:MEDLINE

  8 / 215 MEDLINE  
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[PMID]: 27503064
[Au] Autor:Hiernickel C; Goetze S; Schliemann S; Elsner P
[Ad] Address:Department of Dermatology, University Hospital Jena, Jena, Germany.
[Ti] Title:A dramatic case of malignant atrophic papulosis (Köhlmeier-Degos disease) with fatal outcome.
[So] Source:J Dtsch Dermatol Ges;14(8):839-40, 2016 Aug.
[Is] ISSN:1610-0387
[Cp] Country of publication:Germany
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1608
[Cu] Class update date: 161219
[Lr] Last revision date:161219
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1111/ddg.12698

  9 / 215 MEDLINE  
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[PMID]: 24981687
[Au] Autor:Flühler C; Stinco G; di Meo N; Bonin S; Degrassi F; Bussani R; Cova MA; Trevisan G
[Ad] Address:Insitute of Dermatology and Venereology, Ospedale Maggiore di Trieste, University of Trieste, Trieste, Italy.
[Ti] Title:Malignant form of atrophic papulosis with lethal abdominal involvement.
[So] Source:J Eur Acad Dermatol Venereol;30(1):126-8, 2016 Jan.
[Is] ISSN:1468-3083
[Cp] Country of publication:England
[La] Language:eng
[Mh] MeSH terms primary: Malignant Atrophic Papulosis/diagnosis
[Mh] MeSH terms secundary: Diagnosis, Differential
Fatal Outcome
Female
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS; LETTER
[Em] Entry month:1612
[Cu] Class update date: 161230
[Lr] Last revision date:161230
[Js] Journal subset:IM
[Da] Date of entry for processing:140702
[St] Status:MEDLINE
[do] DOI:10.1111/jdv.12612

  10 / 215 MEDLINE  
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[PMID]: 26850015
[Au] Autor:Xiong J; Chen H; Jiang Y; Xu X; Zhang W; Zeng X; Sun J
[Ad] Address:Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
[Ti] Title:[Lymphomatoid papulosis: a clinicopathologic study of 22 cases].
[So] Source:Zhonghua Yi Xue Za Zhi;95(46):3750-2, 2015 Dec 08.
[Is] ISSN:0376-2491
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To investigate the clinical presentation, histopathological features, progression, and treatment of lymphomatoid papulosis (LyP). METHODS: A retrospective review was performed on clinicopathological data of 22 patients diagnosed with LyP from June 2010 to March 2015 in Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College. RESULT: The mean age of the 22 LyP patients was 39 years (range: 7-83 years). The male-to-female ratio was 1:1. The areas predominantly affected were the trunks, followed by limbs and face. Most lesions presented as recurrent eruption of erythema, papule, nodules, ulcer, necrosis and crusting. Some of them leaved hyperpigmentation or atrophic scars on healing. Histopathologically, LyP were devided into types A, B, C, D and E, with 12, 1, 1, 3, and 4 cases in each type, respectively, and one case of mixed type B and C. One of the patients was also diagnosed with primary cutaneous anaplastic large-cell lymphoma besides the diagnosis of LyP. Among the 15 patients with follow-up information available, 11 patients were treated with regimens including oral corticosteroids, methotrexate, tripchlorolide, intramuscular injection of interferon, phototherapy, and topical corticosteroids. The mean follow-up time was 22 (1-54) months.All the patients were alive at the end of the follow-up period. CONCLUSIONS: LyP is a low-grade malignant T-cell lymphoma with a benign clinical course but histologically malignant features. Multi-agent chemotherapy is unnecessary. Patients with LyP are likely to have an favorable prognosis.
[Mh] MeSH terms primary: Lymphomatoid Papulosis
Skin Neoplasms
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Asian Continental Ancestry Group
Beijing
Child
Disease Progression
Female
Humans
Male
Middle Aged
Prognosis
Retrospective Studies
Young Adult
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1604
[Cu] Class update date: 160206
[Lr] Last revision date:160206
[Js] Journal subset:IM
[Da] Date of entry for processing:160207
[St] Status:MEDLINE


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