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Search on : marchiafava-bignami and disease [Words]
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[PMID]: 29482459
[Au] Autor:Kesayan T; Heilman KM
[Ad] Address:a Department of Neurology , University of South Florida Morsani College of Medicine , Tampa , FL , USA.
[Ti] Title:Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease.
[So] Source:Neurocase;24(1):59-67, 2018 Feb.
[Is] ISSN:1465-3656
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Apraxic agraphia can be caused by left hemispheric cerebral lesions in the area that contains the spatial representations of the movements required to write, from a lesion in, or connections to, the frontal premotor cortex that converts these spatial representations to motor programs (Exner's area).  A right-handed woman with Marchiafava Bignami disease and lesions of the genu and splenium of her corpus callosum had apraxic agraphia without ideomotor apraxia of her left. A disconnection of Exner's area in the left hemisphere from the right hemisphere's premotor and motor areas may have led to her inability to write with her left hand.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1080/13554794.2018.1444780

  2 / 227 MEDLINE  
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[PMID]: 29465574
[Au] Autor:Tsai CY; Huang PK; Huang P
[Ad] Address:Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
[Ti] Title:Simultaneous acute Marchiafava-Bignami disease and central pontine myelinolysis: A case report of a challenging diagnosis.
[So] Source:Medicine (Baltimore);97(8):e9878, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Marchiafava-Bignami disease (MBD) is a rare disease characterized by demyelination of the corpus callosum. It is most commonly seen in patients with chronic alcoholism. The clinical diagnosis of MBD can be difficult due to its nonspecific manifestation. Central pontine myelinolysis (CPM) occurs mostly as a complication of severe and prolonged hyponatremia, especially when corrected too rapidly. However, CPM can be associated with chronic alcoholism and its clinical presentation can be heterogeneous. Because both MBD and CPM can have fatal outcomes, early recognition and treatment can result in a better prognosis. We present a very rare case of simultaneous acute Marchiafava-Bignami disease and central pontine myelinolysis in a patient with chronic alcoholism who was diagnosed unexpectedly using brain magnetic resonance imaging and improved after proper treatment. PATIENT CONCERNS: We presented a case of a 39-year-old patient who visited the hospital with general weakness and an altered neurologic condition after a week of vomiting. DIAGNOSIS: The patient was diagnosed with simultaneous acute Marchiafava-Bignami disease and central pontine myelinolysis using brain magnetic resonance imaging. INTERVENTION: Administration of a high dose of thiamine. OUTCOMES: The neurologic signs improved after a week of thiamine administration. LESSONS: This case suggests that Marchiafava-Bignami disease and central pontine myelinolysis might have a common pathogenesis, and brain magnetic resonance imaging is of crucial importance in chronic alcoholic patients presenting with nonspecific neurological deterioration. The appropriate administration of thiamine may prevent poor outcomes.
[Mh] MeSH terms primary: Marchiafava-Bignami Disease/complications
Marchiafava-Bignami Disease/diagnostic imaging
Myelinolysis, Central Pontine/complications
Myelinolysis, Central Pontine/diagnostic imaging
[Mh] MeSH terms secundary: Adult
Alcoholism/complications
Humans
Magnetic Resonance Imaging
Male
Marchiafava-Bignami Disease/drug therapy
Myelinolysis, Central Pontine/drug therapy
Thiamine/therapeutic use
Vitamin B Complex/therapeutic use
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:12001-76-2 (Vitamin B Complex); X66NSO3N35 (Thiamine)
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009878

  3 / 227 MEDLINE  
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[PMID]: 29384842
[Au] Autor:Dong X; Bai C; Nao J
[Ad] Address:Department of Neurology, Shengjing Hospital of China Medical University, Heping District, Shenyang, Liaoning, People's Republic of China.
[Ti] Title:Clinical and radiological features of Marchiafava-Bignami disease.
[So] Source:Medicine (Baltimore);97(5):e9626, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Marchiafava-Bignami disease (MBD) is a rare neurological disease usually associated with chronic alcoholism and characterized by demyelination and necrosis. Our aims were to describe the clinicoradiological features and identify factors that may affect the prognosis of patients with MBD.We examined clinical manifestations, laboratory results, and neuroradiological features of 9 patients with MBD. The patients were classified into 2 subgroups (favorable and poor outcome subgroups) based on the Modified Oxford Handicap Scale (MOSH). In addition, we compared the clinical and neuroimaging features between the 2 subgroups.Nine adult male patients (age of onset range 37-62 years, with a mean age of 47.00 ±â€Š14.50 years) were included in this study. According to MOSH, 4 patients were placed in the poor outcome subgroup (MOHS ≥ 3), 5 patients were placed in the favorable outcome subgroup (MOHS ≤ 2). Relatively high score of MAST-C (≥6) (P = .008), extracallosal lesions (P = .048), GCS (P = .026), cerebral lobe impairment (P = .048) was significantly more common in the poor outcome subgroup.Clinical manifestations of MBD are variable and lack specificity. Early diagnosis by relatively specific performance of bisymmetric lesions in corpus callosum of diffusion-weighted imaging (DWI) may affect the prognosis. The prognosis of patients with severe disturbance of consciousness, heavy alcohol consumption, extracallosal lesions, cerebral lobe impairment is probably unfavorable.
[Mh] MeSH terms primary: Marchiafava-Bignami Disease/diagnostic imaging
Marchiafava-Bignami Disease/therapy
[Mh] MeSH terms secundary: Adult
Alcohol Drinking/adverse effects
Alcohol Drinking/physiopathology
Alcohol Drinking/psychology
Biomarkers/blood
Brain/diagnostic imaging
Cognition
Diagnosis, Differential
Disability Evaluation
Disease Progression
Follow-Up Studies
Hospitalization
Humans
Magnetic Resonance Imaging
Male
Marchiafava-Bignami Disease/physiopathology
Marchiafava-Bignami Disease/psychology
Middle Aged
Prognosis
Retrospective Studies
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers)
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009626

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[PMID]: 29169770
[Au] Autor:Alghamdi S; Seddeq Y; Algahtani H; Shirah B
[Ad] Address:King Abdulaziz Medical City/King Saud bin Abdulaziz University for Health Sciences, P.O. Box: 12723, Jeddah 21483, Saudi Arabia. Electronic address: Ghamdisa4@ngha.med.sa.
[Ti] Title:Fatal serotonin syndrome in a patient with Marchiafava-Bignami disease: Combined neurological and psychiatric emergency.
[So] Source:Neurol Neurochir Pol;, 2017 Oct 31.
[Is] ISSN:0028-3843
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Marchiafava-Bignami disease (MBD) is a rare fatal neurological disorder characterized by demyelination, primary degeneration, and necrosis of the corpus callosum. Although MBD is mostly associated with chronic alcohol consumption and malnutrition, it has been reported in non-alcoholic patients. Serotonin syndrome is a rare but potentially fatal side effect of antidepressants that results from overstimulation of both central and peripheral serotonergic receptors. In this report, we present a case with fatal serotonin syndrome happening in a non-alcoholic patient with the chronic form of MBD. To our knowledge, this case is the first report of fatal serotonin syndrome due to citalopram in an MBD patient. The present report may indicate that citalopram and other SSRIs should not be used in patients with MBD. Our case is also among few reported cases in the literature where no cause was identified in a patient with no previous history of alcohol intake.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171124
[Lr] Last revision date:171124
[St] Status:Publisher

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[PMID]: 28588358
[Au] Autor:Vargas Canas A; Rivas M; Guerrero Torrealba R; Francisca Fajre Caamano M
[Ad] Address:Unidad de Neurología Hospital Santiago Oriente "Dr. Luis Tisné", Santiago, Chile.
[Ti] Title:Marchiafava-Bignami's Disease, as Etiologic Diagnosis of Athetosis.
[So] Source:Ann Neurosci;24(1):57-60, 2017 May.
[Is] ISSN:0972-7531
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:The Marchiafava-Bignami disease, characterized by demyelination and necrosis of the corpus callosum, has typically been associated with chronic alcohol intake, and clinically has various symptoms and signs. However, several cases have been reported without alcohol association, and these - according to several publications - have some common points, such as preference for female, related to malnutrition, and radiological involvement of the splenium of the corpus callosum. We report a case of a patient with the characteristics described above and whose clinical manifestation was Athetosis. The authors associate this manifestation with the somatotopic distribution of the corpus callosum, and contribute to the etiologic diagnosis of Athetosis as a manifestation of the Marchiafava-Bignami disease, which has not been reported in the medical literature according to our review of the database.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170611
[Lr] Last revision date:170611
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1159/000464424

  6 / 227 MEDLINE  
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[PMID]: 28488640
[Au] Autor:Xuehan LI; Zhiyu LV; Wang P; Chen X
[Ad] Address:Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
[Ti] Title:A rare case of Marchiafava-Bignami disease: Extracallosal lesions involving bilateral medipeduncle.
[So] Source:Neurol India;65(3):642-643, 2017 May-Jun.
[Is] ISSN:0028-3886
[Cp] Country of publication:India
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1705
[Cu] Class update date: 170510
[Lr] Last revision date:170510
[St] Status:In-Data-Review
[do] DOI:10.4103/neuroindia.NI_365_16

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[PMID]: 28225048
[Au] Autor:Fernandes LMP; Bezerra FR; Monteiro MC; Silva ML; de Oliveira FR; Lima RR; Fontes-Júnior EA; Maia CSF
[Ad] Address:Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.
[Ti] Title:Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava-Bignami disease.
[So] Source:Eur J Clin Nutr;71(5):580-586, 2017 May.
[Is] ISSN:1476-5640
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Ethanol is an important risk factor for the occurrence of several brain disorders that depend on the amount, period and frequency of its consumption. Chronic use of ethanol often leads to the development of neurodegenerative syndromes, which cause morphological and functional impairments such as foetal alcohol syndrome in newborns exposed to ethanol during pregnancy, Wernicke-Korsakoff Syndrome and, more rarely, Marchiafava-Bignami disease (MBD). MBD is characterized by primary degeneration of the corpus callosum, without inflammation and is associated with oxidative stress and hypovitaminosis, as well as altered mental status, to mention dementia, seizures, depression and so on. This review discusses MBD and poor nutrition as a risk factor for the development of such alcoholic syndrome, with focus on diagnosis, pathogenic aspects, signs and symptoms, as well as therapeutic perspectives. On the basis of the inclusion/exclusion criteria adopted, the performed search in scientific databases (Pubmed, Scielo and Google Scholar) resulted in 100 studies that are being presented and discussed in the present work. Review, case-control and cohort studies on alcoholism-associated hypovitaminosis, oxidative stress, MBD and ethanol metabolism pathways were admitted as relevant. We highlight that MBD is a poorly described, diagnosed, insidious and progressive condition, for which evidence suggests a synergism between ethanol-induced neurotoxic effects and hypovitaminosis B. Present treatment consists of vitamin B1(thiamine) supplementation. Nonetheless, other strategies such as the inclusion of antidepressants or steroidal anti-inflammatories as add-on therapies have been employed as an attempt to improve the damage. Indeed, both the diagnosis and treatment are difficult, and death occurs within few years.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1702
[Cu] Class update date: 170503
[Lr] Last revision date:170503
[St] Status:In-Process
[do] DOI:10.1038/ejcn.2016.267

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[PMID]: 27987266
[Au] Autor:Logan C; Asadi H; Kok HK; Looby ST; Brennan P; O'Hare A; Thornton J
[Ad] Address:Neuroradiology and Neurointerventional Service, Department of Radiology, Beaumont Hospital, Beaumont, Ireland.
[Ti] Title:Neuroimaging of chronic alcohol misuse.
[So] Source:J Med Imaging Radiat Oncol;61(4):435-440, 2017 Aug.
[Is] ISSN:1754-9485
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:Alcohol is one of the most commonly abused substances worldwide. It results in a wide range of diseases and disorders affecting many organ systems. Alcohol-related nutritional deficiencies and electrolyte disturbance leave chronic abusers at risk of a range of demyelinating conditions to which the radiologist and clinician should always be alert. These include Wernicke's encephalopathy, Korsakoff's syndrome, Marchiafava-Bignami disease and osmotic demyelination. Cerebral volume loss is also a commonly encountered neuroimaging phenomenon in chronic alcohol abusers. Neuroimaging with CT and MR, with a focus on FLAIR and diffusion-weighted MR sequences, play an important role in the diagnosis and often monitoring of these conditions. We present an educational review of these entities in terms of their clinical features, neuropathology and imaging features along with a case example of each condition.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1612
[Cu] Class update date: 170807
[Lr] Last revision date:170807
[St] Status:In-Process
[do] DOI:10.1111/1754-9485.12572

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[PMID]: 27881585
[Au] Autor:Canepa C; Arias L
[Ad] Address:Department of Stroke and Neurology, James Paget University Hospital, Great Yarmouth, Norfolk, UK.
[Ti] Title:Partial interhemispheric disconnection syndrome (P-IHDS) secondary to Marchiafava-Bignami disease type B (MBD-B).
[So] Source:BMJ Case Rep;2016, 2016 Nov 23.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A 53-year-old man with a 35-year history of excessive alcohol intake presents to our neurology department with 4-year history of progressive neurocognitive deterioration and disconnection syndrome. MRI head demonstrates extensive demyelination of the corpus callosum (and of extracallosal sites as well), leading to a diagnosis of Marchiafava-Bignami disease. He was given treatment with vitamin B complex (including folate) and was assessed and managed by psychology, occupational therapy and physiotherapy with initial signs of improvement.
[Mh] MeSH terms primary: Alcoholism/complications
Cognition Disorders/complications
Cognition Disorders/diagnosis
Corpus Callosum/pathology
Marchiafava-Bignami Disease/complications
Marchiafava-Bignami Disease/diagnosis
[Mh] MeSH terms secundary: Alcoholism/diagnosis
Alcoholism/pathology
Alcoholism/therapy
Brain/pathology
Cognition Disorders/therapy
Corpus Callosum/diagnostic imaging
Diagnosis, Differential
Humans
Magnetic Resonance Imaging
Male
Marchiafava-Bignami Disease/therapy
Middle Aged
Occupational Therapy
Physical Therapy Modalities
Syndrome
Vitamin B Complex/therapeutic use
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:12001-76-2 (Vitamin B Complex)
[Em] Entry month:1703
[Cu] Class update date: 170317
[Lr] Last revision date:170317
[Js] Journal subset:IM
[Da] Date of entry for processing:161125
[St] Status:MEDLINE

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[PMID]: 27668107
[Au] Autor:Boloursaz S; Nekooei S; Seilanian Toosi F; Rezaei-Dalouei H; Davachi B; Kazemi S; Abbasi B
[Ad] Address:Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
[Ti] Title:Marchiafava-Bignami and Alcohol Related Acute Polyneuropathy: The Cooccurrence of Two Rare Entities.
[So] Source:Case Rep Neurol Med;2016:5848572, 2016.
[Is] ISSN:2090-6668
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Objectives. The aim of this article is to represent the first reported case with cooccurrence of two rare alcohol related complications. Case Report. We report a 38-year-old man with chronic alcoholism who presented with both cranial and peripheral nerve palsy. On MRI examination characteristic findings of Marchiafava-Bignami disease were recognized. Discussion. Marchiafava-Bignami disease (MBD) is a rare complication of long-term, heavy alcohol abuse that has characteristic MRI findings. Acute alcohol related polyneuropathy (AARP) is another rare and not-well-understood complication of chronic alcohol abuse. We could not find any previous report of the cooccurrence of these two complications in the literature.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1609
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Da] Date of entry for processing:160927
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2016/5848572


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