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[PMID]: 25707990
[Au] Autor:Mair KH; Koinig H; Gerner W; Höhne A; Bretthauer J; Kroll JJ; Roof MB; Saalmüller A; Stadler K; Libanova R
[Ad] Address:Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria....
[Ti] Title:Carbopol improves the early cellular immune responses induced by the modified-life vaccine Ingelvac PRRS(®) MLV.
[So] Source:Vet Microbiol;176(3-4):352-7, 2015 Apr 17.
[Is] ISSN:1873-2542
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Adjuvants enhance both the magnitude and duration of immune responses, therefore representing a central component of vaccines. The nature of the adjuvant can determine the particular type of immune response, which may be skewed toward cytotoxic T cell (CTL) responses, antibody responses, or particular classes of T helper (Th) responses and antibody isotypes. Traditionally, adjuvants have been added to intrinsically poor immunogenic vaccines, such as those using whole killed organisms or subunit vaccines. Here, we have compared cellular immune responses induced by the immunogenic modified life-attenuated vaccine Ingelvac PRRS(®) MLV when administered alone or in combination with carbopol, a widely used adjuvant in veterinary medicine. Using functional readouts (IFN-γ ELISpot and cell proliferation) and analyzing phenotypical hallmarks of CD4T cell differentiation, we show that carbopol improves cellular immunity by inducing early IFN-γ-producing cells and by preferentially driving T cell differentiation to effector phenotypes. Our data suggest that adjuvants may enhance and modulate life-attenuated - not only subunit/inactivated - vaccines.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 1870748 MEDLINE  
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[PMID]: 25770072
[Au] Autor:Reuss SM; Chesen AB
[Ad] Address:Department of Large Animal Clinical Sciences, University of Florida's College of Veterinary Medicine, Gainesville, FL 32610, USA. Electronic address: sreuss@ufl.edu.
[Ti] Title:Updates on respiratory medicine and surgery.
[So] Source:Vet Clin North Am Equine Pract;31(1):xv-xvi, 2015 Apr.
[Is] ISSN:1558-4224
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:EDITORIAL
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 1870748 MEDLINE  
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[PMID]: 25458986
[Au] Autor:Lahlimi FZ; Tazi I; Sifsalam M; Bouchtia M; Mahmal L
[Ad] Address:Service d'hématologie, CHU Mohammed VI, université Cadi Ayyad, Marrakech, Maroc. Electronic address: fatizahra02@hotmail.com....
[Ti] Title:Évaluation de la pratique transfusionnelle : enquête au sein du personnel infirmier du centre d'oncologie-hématologie du CHU Mohammed VI de Marrakech, Maroc. [Assessment of transfusion practice: Assessing nurses' knowledge in transfusion medicine at Mohamed VI Hematology and Oncology Center of Marrakesh, Morocco].
[So] Source:Transfus Clin Biol;22(1):12-6, 2015 Mar.
[Is] ISSN:1953-8022
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:UNLABELLED: Blood transfusion is a complex activity, involving many actors. It is a high-risk activity which could not be controlled without the use of specific methods. Health care workers beliefs and organizational factors are two major issues for the blood transfusion safety. PURPOSE: In our medical center, transfusion medicine care practices were evaluated by testing the nursing staff with a list of questions. We carried out a cross-sectional study. The information was gathered by using an anonymous questionnaire. The latter was developed by foreign teams and adapted to the local context. Forty-two nurses have participated to study. Only 25% have appropriate knowledge and practice with no negative consequences for the patient safety. In our sample, poor knowledge and practice concerned mainly (1) pre-transfusion compatibility check when receiving blood units (30%); (2) delay in preservation of blood unit in the ward (65%); and (3) recognition of abnormal reactions after transfusion (40%). These results showed on which topics the teaching program should emphasize so as to improve the quality of blood transfusion in the medical centers according to legal obligations.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 1870748 MEDLINE  
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[PMID]: 25770252
[Au] Autor:Freyne B; Marchant A; Curtis N
[Ti] Title:BCG-associated heterologous immunity, a historical perspective: intervention studies in animal models of infectious diseases.
[So] Source:Trans R Soc Trop Med Hyg;109(4):287, 2015 Apr.
[Is] ISSN:1878-3503
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/trstmh/trv021

  5 / 1870748 MEDLINE  
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[PMID]: 25770251
[Au] Autor:Parajuli RP; Fujiwara T; Umezaki M; Konishi S; Takane E; Maharjan M; Tachibana K; Jiang HW; Pahari K; Watanabe C
[Ti] Title:Prevalence and risk factors of soil-transmitted helminth infection in Nepal.
[So] Source:Trans R Soc Trop Med Hyg;109(4):286, 2015 Apr.
[Is] ISSN:1878-3503
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/trstmh/trv013

  6 / 1870748 MEDLINE  
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[PMID]: 25770250
[Au] Autor:Frater J
[Ad] Address:Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, John Radcliffe Hospital, Oxford, UK; Institute for Emerging Infections, The Oxford Martin School, Oxford, UK; Oxford National Institute of Health Research Biomedical Research Centre, Oxford, UK john.frater@ndm.ox.ac.uk.
[Ti] Title:Thirty years of treating HIV-1 infection: where next?
[So] Source:Trans R Soc Trop Med Hyg;109(4):229-30, 2015 Apr.
[Is] ISSN:1878-3503
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:EDITORIAL
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/trstmh/trv010

  7 / 1870748 MEDLINE  
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[PMID]: 25732755
[Au] Autor:Walsh MS; Hope E; Isaia L; Righarts A; Niupulusu T; Temese SV; Iosefa-Siitia L; Auvaa L; Tapelu SA; Motu MF; Edwards C; Wernick M; Huston WM; Suaalii-Sauni T; Hill PC
[Ad] Address:Centre for International Health, University of Otago, Dunedin, New Zealand....
[Ti] Title:Prevalence of Chlamydia trachomatis infection in Samoan women aged 18 to 29 and assessment of possible risk factors: a community-based study.
[So] Source:Trans R Soc Trop Med Hyg;109(4):245-51, 2015 Apr.
[Is] ISSN:1878-3503
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Knowledge about genital Chlamydia trachomatis (CT) infections in the Pacific is limited. In this study we investigated CT infection in Samoan women. METHODS: We recruited women having unprotected sex aged 18 to 29 years from 41 Samoan villages. They completed a questionnaire and provided a urine sample for CT testing by PCR. Associations between CT infection and possible risk factors were explored using logistic regression. RESULTS: Altogether, 239 women were recruited; 86 (36.0%; weighted estimate of prevalence: 41.9%; 95% CI: 33.4-50.5%) were positive for CT infection. A higher proportion of women aged 18 to 24 were positive (54/145; 37.2%) than those aged 25 to 29 (32/94; 34.0%; p=0.20). Being single (OR 1.92; 95% CI: 1.02-3.63) and having two or more lifetime sexual partners (OR 3.02; 95% CI: 1.19-7.67) were associated with CT infection; 27.6% of those with one lifetime partner were positive. Participants who had a previous pregnancy were less likely to be positive (OR 0.49; 95% CI: 0.27-0.87). Primiparous and multiparous women were less likely to be positive than nulliparous women (OR 0.54; 95% CI: 0.30-0.99 and OR 0.46; 95% CI: 0.24-0.89, respectively). CONCLUSIONS: The prevalence of CT infection in these Samoan women is very high. Further studies, including investigating the prevalence of CT infection in men, and strategies for sustainable control are needed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/trstmh/trv014

  8 / 1870748 MEDLINE  
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[PMID]: 25673628
[Au] Autor:Stanton MC; Smith EL; Martindale S; Mkwanda SZ; Kelly-Hope LA
[Ad] Address:Centre for Neglected Tropical Diseases, Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK michelle.stanton@lstmed.ac.uk....
[Ti] Title:Exploring hydrocoele surgery accessibility and impact in a lymphatic filariasis endemic area of southern Malawi.
[So] Source:Trans R Soc Trop Med Hyg;109(4):252-61, 2015 Apr.
[Is] ISSN:1878-3503
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Hydrocoele surgery is the recommended treatment for the common clinical manifestation of lymphatic filariasis in men. This study determined the geographical differences in surgery accessibility, and improvements in the quality of life of patients in Chikwawa district, Malawi. METHODS: Surgery records from Chikwawa District Hospital (CDH), between 2008 and 2013, were used to map surgery rates by village, spatial dependence by census enumeration area and relationship of distance (kilometres) to CDH. A subset of patients were selected to quantify and compare their physical and socio-economic well-being and level of disability pre- and post-surgery using a standardised questionnaire. RESULTS: A total of 476 hydrocoele surgical cases were identified with 260 cases geo-referenced and mapped. A significant negative relationship between village-level surgery rates and distance to CDH (r=-0.137; 95% CI: -0.47 to -0.26) was found, and clusters of enumeration areas with high surgery rates identified around the CDH. Significant improvements in patients' ability to walk and work were found and the overall level of disability was reduced post-surgery. CONCLUSIONS: Hydrocoele surgery positively impacted on patients, improving their physical and socio-economic output. Surgical services need to scale-up and expand to reach cases that have less access to the best treatment currently available.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/trstmh/trv009

  9 / 1870748 MEDLINE  
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[PMID]: 25634640
[Au] Autor:Heringer M; Nogueira RM; de Filippis AM; Lima MR; Faria NR; Nunes PC; Nogueira FB; Dos Santos FB
[Ad] Address:Flavivirus Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Av Brasil 4365, Manguinhos, Rio de Janeiro, RJ, 21045-360, Brazil....
[Ti] Title:Impact of the emergence and re-emergence of different dengue viruses' serotypes in Rio de Janeiro, Brazil, 2010 to 2012.
[So] Source:Trans R Soc Trop Med Hyg;109(4):268-74, 2015 Apr.
[Is] ISSN:1878-3503
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Rio de Janeiro (RJ) has been of major importance for the epidemiology of dengue viruses (DENVs) in Brazil. After the DENV 1-4 introductions in 1986, 1990, 2000 and 2011, respectively, the state has suffered explosive epidemics. We aimed to describe laboratorial, epidemiological and clinical aspects due to the emergence and re-emergence of distinct DENV in a 2-year period. METHODS: Suspected dengue cases (n=2833), including 190 fatal cases, were submitted to virus isolation, RT-PCR and non-structural 1 (NS1) antigen capture ELISA, IgM antibody-capture (MAC)-ELISA and IgG-ELISA. RESULTS: Case confirmation was 47.5%. MAC-ELISA confirmed 32.6% of the cases, RT-PCR confirmed 56.3%; DENV was recovered in 33.1% of samples inoculated and NS1 ELISA confirmed 27.5% of the cases. DENV-2 was prevalent in 2010, DENV-1 in 2011 and DENV-4 in 2012. Individuals infected by DENV-3 and over 65 years-old, and children 15 years-old and under infected by DENV-2 had a significantly higher risk of developing a severe disease. Fatal cases confirmed (n=67) were due to DENV-1 (26.8%), DENV-2 (14.9%), DENV-3 (2.9%) and DENV-4 (7.4%). CONCLUSIONS: It has been shown here that viral emergences or re-emergences may play different roles in the disease epidemiology, especially when many serotypes co-circulate.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/trstmh/trv006

  10 / 1870748 MEDLINE  
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[PMID]: 25618132
[Au] Autor:George S; Kaliappan SP; Kattula D; Roy S; Geldhof P; Kang G; Vercruysse J; Levecke B
[Ad] Address:Department of Virology, Parasitology and Immunology, Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India....
[Ti] Title:Identification of Ancylostoma ceylanicum in children from a tribal community in Tamil Nadu, India using a semi-nested PCR-RFLP tool.
[So] Source:Trans R Soc Trop Med Hyg;109(4):283-5, 2015 Apr.
[Is] ISSN:1878-3503
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: It is generally assumed that hookworm infections in humans are caused by Necator americanus and Ancylostoma duodenale. However, previous studies have also reported the presence of the animal hookworm A. ceylanicum in human stools. METHODS: We determined hookworm infections in children in a tribal community in Tamil Nadu, India, using a semi-nested PCR-RFLP approach. RESULTS: The results indicate that human species account for a majority of the hookworm infections (N. americanus 39/41 [95%]; A. duodenale 6/41 [15%]), whereas the animal hookworm A. ceylanicum only accounts for a minority of the infections (5%; 2/41). CONCLUSIONS: The results emphasize the need to consider zoonotic ancylostomiasis while developing strategies to control hookworm infections.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/trstmh/trv001


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