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[PMID]: 23998685
[Au] Autor:Gornik KR; Pirie CG; Duker JS; Boudrieau RJ
[Ad] Address:Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA, 01536, USA.
[Ti] Title:Canine multifocal retinopathy caused by a BEST1 mutation in a Boerboel.
[So] Source:Vet Ophthalmol;17(5):368-72, 2014 Sep.
[Is] ISSN:1463-5224
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A 7-month-old male intact Boerboel presented to the Cummings School of Veterinary Medicine at Tufts University for the evaluation of ocular discharge. Bilateral multifocal serous retinal detachments were noted on fundus examination as an incidental finding. Genetic testing confirmed the dog to be homozygous for a mutation in the BEST1 gene, where a C73 T/R25 X change results in premature termination codon. Further testing, including electroretinography and optical coherence tomography (OCT), demonstrated that there was no evidence of retinal photoreceptor dysfunction and confirmed that observed lesions were characteristic of canine multifocal retinopathy. No progression of the lesions was noted 3 months after the initial examination. To the authors' knowledge, this is the first report of canine multifocal retinopathy in the Boerboel breed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/vop.12095

  2 / 1845494 MEDLINE  
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[PMID]: 25194455
[Au] Autor:Kothapalli SV; Oddo L; Paradossi G; Brodin LÅ; Grishenkov D
[Ad] Address:Department of Medical Engineering, School of Technology and Health, KTH, Royal Institute of Technology, Sweden....
[Ti] Title:Assessment of the Viscoelastic and Oscillation Properties of a Nano-engineered Multimodality Contrast Agent.
[So] Source:Ultrasound Med Biol;40(10):2476-87, 2014 Oct.
[Is] ISSN:1879-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Combinations of microbubbles (MBs) and superparamagnetic iron oxide nanoparticles (SPIONs) are used to fabricate dual contrast agents for ultrasound and MRI. This study examines the viscoelastic and oscillation characteristics of two MB types that are manufactured with SPIONs and either anchored chemically on the surface (MBs-chem) or physically embedded (MBs-phys) into a polymer shell. A linearized Church model was employed to simultaneously fit attenuation coefficients and phase velocity spectra that were acquired experimentally. The model predicted lower viscoelastic modulus values, undamped resonance frequencies and total damping ratios for MBs-chem. MBs-chem had a resonance frequency of approximately 13 MHz and a damping ratio of approximately 0.9; thus, MBs-chem can potentially be used as a conventional ultrasound contrast agent with the combined functionality of MRI detection. In contrast, MBs-phys had a resonance frequency and damping of 28 MHz and 1.2, respectively, and requires further modification of clinically available contrast pulse sequences to be visualized.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 1845494 MEDLINE  
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[PMID]: 25194454
[Au] Autor:Bártová P; Kraft O; Bernátek J; Havel M; Ressner P; Langová K; Herzig R; Skoloudík D
[Ad] Address:Department of Neurology, Ostrava University and University Hospital, Ostrava, Czech Republic. Electronic address: petrabartova@seznam.cz....
[Ti] Title:Transcranial Sonography and (123)I-FP-CIT Single Photon Emission Computed Tomography in Movement Disorders.
[So] Source:Ultrasound Med Biol;40(10):2365-71, 2014 Oct.
[Is] ISSN:1879-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Diagnosis of Parkinson's disease (PD) can be difficult in the early stages of the disease. The aim of the study described here was to assess the correlation between transcranial sonography (TCS) and (123)I-FP-CIT ([(123)I]ioflupane, N-ω-fluoropropyl-2ß-carbomethoxy-3ß-(4-[(123)I]iodophenyl)nortropane) SPECT (single photon emission computed tomography) findings and the diagnosis of PD. A total of 49 patients were enrolled in the study: 29 patients with PD, 7 patients with other parkinsonian syndromes, 11 patients with essential tremor and 2 with psychogenic movement disorder. Substantia nigra echogenicity was measured using TCS. SPECT was performed using DaTSCAN ([(123)I]ioflupane). TCS and SPECT findings were correlated in 84% of patients, with κ = 0.62 (95% confidence interval: 0.38-0.86). TCS-measured substantia nigra echogenicity and SPECT-measured striatal binding ratio were negatively correlated (r = -0.326, p = 0.003). TCS/SPECT sensitivity, specificity and positive and negative predictive values for the diagnosis of PD were 89.7%/96.6%, 60.0%/70.0%, 76.5%/82.4% and 80.0%/93.3%, respectively. Both positive TCS and SPECT findings correlated significantly with the diagnosis of PD (κ = 0.52, 95% confidence interval: 0.27-0.76, and κ = 0.69, 95% confidence interval: 0.49-0.90, respectively).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 1845494 MEDLINE  
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[PMID]: 25130453
[Au] Autor:Ten Cate DF; Luime JJ; Hazes JM; Kleinrensink GJ; Jacobs JW
[Ad] Address:Department of Rheumatology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: d.tencate@erasmusmc.nl....
[Ti] Title:Is the Frequent Sonographic Anechoic Area Distally in Metacarpophalangeal Joints a Sign of Arthritis?
[So] Source:Ultrasound Med Biol;40(10):2537-41, 2014 Oct.
[Is] ISSN:1879-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In clinical practice, ultrasonography (US) often reveals, in the dorsal scan, a small anechoic area distally in both inflamed and clinically non-inflamed metacarpophalangeal joints. This "distal anechogenicity in the metacarpophalangeal joint" (DAEM) might thus be scored false positively as arthritis. We aimed to investigate whether the DAEM is a sign of arthritis. We evaluated the prevalence of DAEMs in 24 non-arthritic subjects. We then compared the dimensions of the DAEM in 10 non-arthritic subjects with a DAEM and 7 consecutive rheumatoid arthritis (RA) outpatients, using 2-D and 3-D ultrasound. Furthermore, we dissected two fresh-frozen postmortem hand specimens after US. A DAEM was observed in the metacarpophalangeal 2 (MCP2) joints of 54% of the 24 non-selected non-arthritic individuals; in none of those did the joint exhibit a power Doppler signal. A DAEM was observed in 86% of the 7 RA patients. Dimensions of DAEMs did not statistically significantly differ between these groups. At 3-D imaging and dissection, the DAEM was found to be an extension of the metacarpophalangeal joint capsule. In conclusion, DAEMs occur frequently and are not a sign of arthritis, but are distal joint recesses. This should be taken into account when using current sensitive ultrasonographic scoring systems grading arthritis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 1845494 MEDLINE  
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[PMID]: 25130452
[Au] Autor:Yoshii Y; Ishii T; Etou F; Sakai S; Tanaka T; Ochiai N
[Ad] Address:Department of Orthopaedic Surgery, Endowed Department of Human Resources Development for Community Medicine, Tokyo Medical University Ibaraki Medical Center, Ami, Japan. Electronic address: yy12721@yahoo.co.jp....
[Ti] Title:Reliability of automatic vibratory equipment for ultrasonic strain measurement of the median nerve.
[So] Source:Ultrasound Med Biol;40(10):2352-7, 2014 Oct.
[Is] ISSN:1879-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The objective of this study was to test the reliability of ultrasonic median nerve strain measurements using automatic vibratory equipment. Strain ratios of the median nerve in the carpal tunnel model and the reference coupler were measured at three different settings of the transducer: 0, +2 and +4 mm (+ = compressing the model down 2-4 mm initially). After measurement of the carpal tunnel model, a +4-mm setting was chosen for in vivo measurement. The median nerve strains of 30 wrists were measured by two examiners using the equipment. Intra- and inter-examiner correlation coefficients (CCs) for the strain ratios were calculated. The closest ratio was found in the +4-mm placement (strain ratio: 0.73, Young's modulus ratio: 0.79). The intra-examiner CC was 0.91 (p < 0.01), and the inter-examiner CCs were 0.72-0.78 (p < 0.01). The automatic vibratory equipment was useful in quantifying median nerve strain at the wrist.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 1845494 MEDLINE  
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[PMID]: 25130451
[Au] Autor:Wei H; Shi L; Zhang J; Xia Y; Cuan J; Zhang Y; Li W; Yan A; Jiang X; Lang MF; Sun J
[Ad] Address:Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address: hongquanwei@163.com....
[Ti] Title:High-intensity focused ultrasound leads to histopathologic changes of the inferior turbinate mucosa with allergic inflammation.
[So] Source:Ultrasound Med Biol;40(10):2425-30, 2014 Oct.
[Is] ISSN:1879-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This study was aimed at understanding the histopathologic changes that occur in the nasal mucosa of patients with perennial allergic rhinitis after high-intensity focused ultrasound (HIFU) treatment. Biopsy specimens of the inferior turbinate mucosa were taken from 11 PAR patients before, immediately after and 1 y after HIFU treatment. Morphometric analysis revealed that the density of eosinophils and other inflammatory cells increased immediately after treatment and then were decreased significantly 1 y post-treatment. Submucosal glands were swollen and venous sinusoids were dilated, but there was no statistically significant change in their density, immediately after treatment. However, both glands and venous sinusoids significantly decreased in number 1 y after HIFU treatment. The ciliated epithelium or basement membrane of the nasal mucosa was well preserved at all stages. In conclusion, HIFU is a tolerable and effective treatment to reduce inflammation of the inferior turbinate mucosa in patients with perennial allergic rhinitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 1845494 MEDLINE  
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[PMID]: 25130450
[Au] Autor:Arbeille P; Provost R; Zuj K; Dimouro D; Georgescu M
[Ad] Address:UMPS-CERCOM (Unite Medecine Physiologie Spatiales), Medecine Nucleaire et Ultrasons, Hopital Universitaire Trousseau, Tours, France. Electronic address: arbeille@med.univ-tours.fr....
[Ti] Title:Teles-operated Echocardiography Using a Robotic Arm and an Internet Connection.
[So] Source:Ultrasound Med Biol;40(10):2521-9, 2014 Oct.
[Is] ISSN:1879-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The objective was to design and validate a method of tele-operated echocardiography. The method was tested in a hospital facility with an expert sonographer located in a room 10 m away from the patient. An ultrasound probe, fixed to a motorized probe holder, was located on the patient by a non-sonographer and was remotely controlled by the expert sonographer via an Internet connection. Scans were performed on 41 cardiac patients. The quality of the cardiac views obtained using tele-echocardiography was lower than that of reference echocardiography, but generated similar measurements in 93%-100% of the cases. Bland-Altman plots and statistical comparison of tele- and reference echocardiography measures revealed no differences (p > 0.05). Of the 71 valve leaks or aortic stenoses present, 61 (86%) were detected using tele-echocardiography. These results indicate that tele-echocardiography provided reliable diagnoses and acceptable measurements in 86% and 93% of cases, respectively, with no false-positive diagnoses being reported.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 1845494 MEDLINE  
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[PMID]: 25130449
[Au] Autor:Kilroy JP; Klibanov AL; Wamhoff BR; Bowles DK; Hossack JA
[Ad] Address:Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA....
[Ti] Title:Localized in Vivo Model Drug Delivery with Intravascular Ultrasound and Microbubbles.
[So] Source:Ultrasound Med Biol;40(10):2458-67, 2014 Oct.
[Is] ISSN:1879-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:An intravascular ultrasound (IVUS) and microbubble drug delivery system was evaluated in both ex vivo and in vivo swine vessel models. Microbubbles with the fluorophore DiI embedded in the shell as a model drug were infused into ex vivo swine arteries at a physiologic flow rate (105 mL/min) while a 5-MHz IVUS transducer applied ultrasound. Ultrasound pulse sequences consisted of acoustic radiation force pulses to displace DiI-loaded microbubbles from the vessel lumen to the wall, followed by higher-intensity delivery pulses to release DiI into the vessel wall. Insonation with both the acoustic radiation force pulse and the delivery pulse increased DiI deposition 10-fold compared with deposition with the delivery pulse alone. Localized delivery of DiI was then demonstrated in an in vivo swine model. The theoretical transducer beam width predicted the measured angular extent of delivery to within 11%. These results indicate that low-frequency IVUS catheters are a viable method for achieving localized drug delivery with microbubbles.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 1845494 MEDLINE  
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[PMID]: 25130448
[Au] Autor:Kumagai H; Yokoyama K; Katsuyama K; Hara S; Yamamoto H; Yamagata T; Taniguchi N; Hirota N; Itoh K
[Ad] Address:Department of Pediatrics, Jichi Medical University, Tochigi, Japan. Electronic address: h-kumagai@jichi.ac.jp....
[Ti] Title:A New Method for Measuring the Speed of Sound in Rat Liver ex Vivo Using an Ultrasound System: Correlation of Sound Speed with Fat Deposition.
[So] Source:Ultrasound Med Biol;40(10):2499-507, 2014 Oct.
[Is] ISSN:1879-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The speed of sound correlates well with the fat content of the liver. Therefore, non-invasive quantification of sound speed in the liver might be of diagnostic value. Here we describe a new non-invasive method that would be clinically applicable for measurement of sound speed in the liver. Sprague-Dawley rats were divided into two groups: a control group and a fatty liver group prepared by keeping the rats on a choline-deficient diet for 6 wk. The livers were subjected to pathologic and biochemical analysis; the speed of sound through the liver tissue was measured using our proposed method and a pulser-receiver as standard. Our results indicated that use of the proposed method makes it feasible to diagnose fatty liver with good accuracy on the basis of sound speed. This approach would have considerable potential for non-invasive diagnosis of fatty liver and would be a valuable adjunct to conventional liver diagnostic procedures.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 1845494 MEDLINE  
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[PMID]: 25130447
[Au] Autor:Buschschlüter S; Koch C; von Eicken J; Höh H
[Ad] Address:Physikalisch-Technische Bundesanstalt, Braunschweig, Germany. Electronic address: steffen.buschschlueter@ptb.de....
[Ti] Title:Computation of the Temperature Rise at the Corneal Endothelium during Cataract Surgery by Modeling of Heat Generation Inside the Anterior Chamber.
[So] Source:Ultrasound Med Biol;40(10):2431-44, 2014 Oct.
[Is] ISSN:1879-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The corneal endothelium sustaining the transparency of the cornea is a vulnerable cell layer. Thermal exposure during phacoemulsification is considered to be a potential cause of post-operative cell loss. Knowledge of the temperature rise and particularly of its dependence on region and system settings could deliver useful information about a potential correlation with cell damage. However, there exists a lack of understanding of the process and location of heat generation. Analytical calculations and experiments enabled the quantification of different mechanisms acting as heat sources during phacoemulsification. Heat generation caused by viscous friction was estimated using both an analytical approach and a numerical simulation. In contrast to absorption of sound and self-heating of the probe, this effect was ascertained to be the main heat source. Calorimetric measurement of the power input verified this modeling. On the basis of these results, the local temperature distribution inside a porcine eye was computed time dependently using the finite-element method. Two different amplitude settings were compared with respect to the temperature increase at the corneal endothelium. Various conclusions on the mitigation of thermal exposure during treatment can be drawn from this finite-element simulation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review


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