Database : MEDLINE
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  1 / 1833425 MEDLINE  
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[PMID]: 24889058
[Au] Autor:Hespel AM; Wilhite R; Hudson J
[Ad] Address:Clinical Sciences, Auburn University, Auburn, AL 36849.
[Ti] Title:Invited review-applications for 3d printers in veterinary medicine.
[So] Source:Vet Radiol Ultrasound;55(4):347-58, 2014 Jul.
[Is] ISSN:1740-8261
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Recent technological advances in 3D printing have resulted in increased use of this technology in human medicine, and decreasing cost is making it more affordable for veterinary use. Rapid prototyping is at its early stage in veterinary medicine but clinical, educational, and experimental possibilities exist. Techniques and applications, both current and future, are explored and illustrated in this article.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/vru.12176

  2 / 1833425 MEDLINE  
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[PMID]: 24907477
[Au] Autor:Sharma V; Thangaraj K; Jyothy A
[Ad] Address:Department of Biotechnology, University College of Science, Osmania University, Hyderabad, India. Electronic address: drvikasonline@gmail.com.
[Ti] Title:A novel androgen receptor gene mutation in a patient with congenital adrenal hyperplasia associated with penoscrotal hypospadias.
[So] Source:Transl Res;164(2):149-52, 2014 Aug.
[Is] ISSN:1878-1810
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Congenital adrenal hyperplasia (CAH) associated with penoscrotal hypospadias is a rare case of disorders of sex development. Here, we report clinical, genetic, biochemical, and molecular findings in a 2-year-old infant with CAH and penoscrotal hypospadias. Chromosomal analysis revealed 46,XX karyotype. Hormonal investigations indicated low levels of cortisol and elevated levels of testosterone, 17-hydroxyprogesterone, and androstenedione hormone. Molecular genetic testing of androgen receptor (AR) gene identified a novel homozygous missense mutation of single nucleotide transition G to A at position 2058 (GenBank accession number GU784855), resulting in amino acid interchange alanine to threonine at codon 566 in exon 2 (Ala566Thr) (GenBank Protein_id ADD26777.1). The nature of the mutation presented is in the highly conserved DNA-binding domain of the AR gene. The novel mutation identified in the rare genetic disorder provides additional support to the previously reported genotype-phenotype correlations, and our finding has expanded the spectrum of known mutations of the AR gene.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  3 / 1833425 MEDLINE  
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[PMID]: 24837849
[Au] Autor:Purdue E
[Ad] Address:Hospital for Special Surgery, New York, NY. Electronic address: purduee@hss.edu.
[Ti] Title:Aneurysmal bone cysts: denosumab extends its reach.
[So] Source:Transl Res;164(2):135-8, 2014 Aug.
[Is] ISSN:1878-1810
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  4 / 1833425 MEDLINE  
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[PMID]: 24746869
[Au] Autor:Belsito A; Costa D; Napoli C
[Ad] Address:U.O.C. Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), Regional Reference Laboratory of Transplant Immunology (LIT), Azienda Universitaria Policlinico (AOU), Second University of Naples, Naples, Italy. Electronic address: angela.belsito@unina2.it.
[Ti] Title:Blood group genotyping for patients with autoimmune hemolytic anemia.
[So] Source:Transl Res;164(2):177-8, 2014 Aug.
[Is] ISSN:1878-1810
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1407
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  5 / 1833425 MEDLINE  
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[PMID]: 24726460
[Au] Autor:Pelle DW; Ringler JW; Peacock JD; Kampfschulte K; Scholten DJ; Davis MM; Mitchell DS; Steensma MR
[Ad] Address:Laboratory of Musculoskeletal Oncology, Center for Skeletal Disease and Tumor Metastasis, Van Andel Institute, Grand Rapids, Mich; Department of Orthopaedic Surgery, Grand Rapids Medical Education Partners, Grand Rapids, Mich. Electronic address: Dominic.pelle@vai.org....
[Ti] Title:Targeting receptor-activator of nuclear kappaB ligand in aneurysmal bone cysts: verification of target and therapeutic response.
[So] Source:Transl Res;164(2):139-48, 2014 Aug.
[Is] ISSN:1878-1810
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Aneurysmal bone cyst (ABC) is a benign tumor of bone presenting as a cystic, expansile lesion in both the axial and appendicular skeleton. Axial lesions demand special consideration, because treatment-related morbidity can be devastating. In similar lesions, such as giant cell tumor of bone (GCTB), the receptor-activator of nuclear kappaB ligand (RANKL)-receptor-activator of nuclear kappaB (RANK) signaling axis is essential to tumor progression. Although ABC and GCTB are distinct entities, they both contain abundant multinucleated giant cells and are osteolytic characteristically. We hypothesize that ABCs express both RANKL and RANK similarly in a cell-type specific manner, and that targeted RANKL therapy will mitigate ABC tumor progression. Cellular expression of RANKL and RANK was determined in freshly harvested ABC samples using laser confocal microscopy. A consistent cell-type-specific pattern was observed: fibroblastlike stromal cells expressed RANKL strongly whereas monocyte/macrophage precursor and multinucleated giant cells expressed RANK. Relative RANKL expression was determined by quantitative real-time polymerase chain reaction in ABC and GCTB tissue samples; no difference in relative expression was observed (P > 0.05). In addition, we review the case of a 5-year-old boy with a large, aggressive sacral ABC. After 3 months of targeted RANKL inhibition with denosumab, magnetic resonance imaging demonstrated tumor shrinkage, bone reconstitution, and healing of a pathologic fracture. Ambulation, and bowel and bladder function were restored at 6 months. Denosumab treatment was well tolerated. Post hoc analysis demonstrated strong RANKL expression in the pretreatment tumor sample. These findings demonstrate that RANKL-RANK signal activation is essential to ABC tumor progression. RANKL-targeted therapy may be an effective alternative to surgery in select ABC presentations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  6 / 1833425 MEDLINE  
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[PMID]: 24631063
[Au] Autor:Rathore K; Alexander M; Cekanova M
[Ad] Address:Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee.
[Ti] Title:Piroxicam inhibits Masitinib-induced cyclooxygenase 2 expression in oral squamous cell carcinoma cells in vitro.
[So] Source:Transl Res;164(2):158-68, 2014 Aug.
[Is] ISSN:1878-1810
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Development and characterization of animal models for human cancers is important for the improvement of diagnosis and therapy. The oral squamous cell carcinoma (OSCC) of domestic animals resembles human OSCC in many aspects; thus, cell lines derived from OSCC of cats and dogs are a valuable model for human OSCC. We characterized 1 feline OSCC (FeOSCC-Sidney) and 1 canine OSCC (K9OSCC-Abby) cell line and compared their characteristics with human OSCC cell line hSCC-25. We calculated the doubling time of the new OSCC cell lines and evaluated the expression profiles of cancer-related markers and cell-cycle proteins such as c-kit, platelet-derived growth factor receptor, vascular endothelial growth factor receptor, epidermal growth factor receptor, cyclooxygenase (COX)-1, COX-2, and p27 by immunocytochemistry and Western blot analysis. We evaluated the effects of novel receptor tyrosine kinase inhibitor (Masitinib, AB1010) and the nonsteroidal anti-inflammatory drug piroxicam on the previously mentioned OSCC cells. Interestingly, AB1010 increased expression levels of COX-2 in all tested OSCCs. Cotreatment of piroxicam with Masitinib significantly inhibited cell proliferation of OSCC as compared to either drug alone through the c-kit and AKT signaling pathways. Piroxicam inhibited Masitinib-induced COX-2 expression in all tested OSCCs. Therefore, targeting these two signaling pathways simultaneously was more efficient for inhibition of OSCCs across these species.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  7 / 1833425 MEDLINE  
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[PMID]: 24530607
[Au] Autor:Priyadarshini M; Thomas A; Reisetter AC; Scholtens DM; Wolever TM; Josefson JL; Layden BT
[Ad] Address:Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL....
[Ti] Title:Maternal short-chain fatty acids are associated with metabolic parameters in mothers and newborns.
[So] Source:Transl Res;164(2):153-7, 2014 Aug.
[Is] ISSN:1878-1810
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:During the course of pregnancy, dynamic remodeling of the gut microbiota occurs and contributes to maternal metabolic changes through an undefined mechanism. Because short chain fatty acids (SCFAs) are a major product of gut microbiome fermentation, we investigated whether serum SCFA levels during pregnancy are related to key metabolic parameters in mothers and newborns. In this prospective study, 20 pregnant women without gestational diabetes were evaluated at 36-38 weeks of gestation, and their newborns were assessed after parturition. In this cohort, which included normal (n = 10) and obese (n = 10) subjects based on prepregnancy body mass index, serum levels of SCFAs (acetate, propionate, and butyrate), maternal adipokines, maternal glucose, and C-peptide were measured at 36-38 weeks of gestation. Maternal weight gain and newborn anthropometrics were also determined. Data were analyzed using linear regression to test for associations, adjusting for prepregnancy obesity. In this cohort, serum acetate levels were associated with maternal weight gain and maternal adiponectin levels. In addition, serum propionate correlated negatively with maternal leptin levels, newborn length, and body weight. Taken together, this study observed that novel relationships exist among maternal SCFA levels and multiple interrelated maternal/newborn metabolic parameters.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  8 / 1833425 MEDLINE  
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[PMID]: 24462762
[Au] Autor:Lu CY; Huang CW; Hu HM; Tsai HL; Huang CM; Yu FJ; Huang MY; Chang SF; Huang ML; Wang JY
[Ad] Address:Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan....
[Ti] Title:Prognostic advantage of irinotecan dose escalation according to uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping in patients with metastatic colorectal cancer treated with bevacizumab combined with 5-fluorouracil/leucovorin with irinotecan in a first-line setting.
[So] Source:Transl Res;164(2):169-76, 2014 Aug.
[Is] ISSN:1878-1810
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This study compared the clinical responses of patients with metastatic colorectal cancer (mCRC) with 5-fluorouracil/leucovorin with irinotecan (FOLFIRI) plus bevacizumab therapy either with or without uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping and irinotecan dose escalation. Of 107 total patients with mCRC, 79 were classified as the study group and 28 as the control group. The study group received irinotecan dose escalation based on UGT1A1 genotyping whereas the control group did not. Clinicopathologic features, response rates, and survival were compared for the 2 groups. The clinical response rate of patients with mCRC treated with FOLFIRI plus bevacizumab under UGT1A1 genotyping and irinotecan dose escalation was significantly better than that of those without these prospective tests and dose escalation (P = 0.028). Both progression-free survival (PFS) and overall survival were significantly greater in clinical responders than nonresponders (both, P < 0.001), and PFS was significantly greater among the study group patients than among the control group patients, with a median PFS of 12.2 months vs 9.4 months (P = 0.025). Grade 3/4 adverse events were not significantly different between the 2 groups (P = 0.189). Patients with mCRC undergoing UGT1A1 genotyping may receive escalated doses of irinotecan to obtain a better clinical response/outcome with comparable toxicities.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  9 / 1833425 MEDLINE  
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[PMID]: 25041152
[Au] Autor:Vergara-Lluri ME; Zhang H; Iqbal JZ
[Ad] Address:West Los Angeles Veterans Administration Hospital, Los Angeles, CA.
[Ti] Title:Integrated coagulation consultation for transfusion medicine.
[So] Source:Transfusion;54(7):1902-3, 2014 Jul.
[Is] ISSN:1537-2995
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/trf.12664

  10 / 1833425 MEDLINE  
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[PMID]: 24689786
[Au] Autor:Eichbaum Q; Shan H; Goncalez TT; Duits AJ; Knox P; Reilly J; Andrews D
[Ad] Address:Transfusion Medicine Division, Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee.
[Ti] Title:Global health and transfusion medicine: education and training in developing countries.
[So] Source:Transfusion;54(7):1893-8, 2014 Jul.
[Is] ISSN:1537-2995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Education and training in transfusion medicine have improved over the past decade in developing countries but are still generally deficient for the purpose of maintaining the safety of the global blood supply. In 2009, the World Health Organization global database on blood safety indicated that only 72% of countries in the world were able to meet their training needs necessary for maintaining the safety of their local blood supply. Educational approaches in transfusion medicine vary widely between continents and world regions. In this article, we summarize a session on global health education and training in developing countries that took place at the 2012 AABB conference. The panel consisted of transfusion representatives from South America (Brazil), Asia (China), Africa (South Africa), and the Caribbean (Curaçao), as well as a description of capacitation issues in postearthquake Haiti and the pivotal role of the US President's Emergency Plan for AIDS Relief (PEPFAR) in transfusion training and education in Africa. We present here summaries of each of these panel presentations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/trf.12609


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