Database : MEDLINE
Search on : mikulicz' and disease [Words]
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[PMID]: 29309109
[Au] Autor:Bozic K; Glisic B; Radic-Tasic O; Knezevic B
[Ti] Title:Case report of Mikulicz's disease: A modern concept of an old entity.
[So] Source:Vojnosanit Pregl;73(4):393-6, 2016 Apr.
[Is] ISSN:0042-8450
[Cp] Country of publication:Serbia
[La] Language:eng
[Ab] Abstract:Introduction: Modern knowlegde defines Mikulicz´s disease as a part of immunoglobulin G4-related disease. The main feature is the presence of lymphoplasmacytic infiltrates, immunoglobulin G4 plasma cells positivity, distinctive storiform fibrosis and moderate eosinophilia. Case Report: A 59-years old male presented with a mild keratoconjuctivitis sicca and enlarged lacrimal and salivary glands during the last two years. Althought clinical presentation of the patient was typical, earlier testing did not pinpoint Mikulicz ´s disease. By typical clinical presentation, elevated serum immunoglobulin G4 level and histopathological finding of lacrimal glands tissue we diagnosed Mikulicz´s disease successfully treated with corticosteroid therapy. Conclusion: We reported the first case of IgG4-related Mikulicz´s disease in Serbia. Our report highlights IgG4-related Mikulicz` s disease as an important differential diagnosis with Sjögren`s syndrome and lymphoproliferative disease in rheumatological practice.
[Mh] MeSH terms primary: Mikulicz´ Disease/diagnosis
[Mh] MeSH terms secundary: Diagnosis, Differential
Humans
Immunoglobulin G/blood
Immunoglobulin G/metabolism
Immunohistochemistry
Lacrimal Apparatus/immunology
Lymphoproliferative Disorders/diagnosis
Male
Middle Aged
Mikulicz' Disease/immunology
Plasma Cells/immunology
Serbia
Sjogren's Syndrome/diagnosis
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunoglobulin G)
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[Js] Journal subset:IM
[Da] Date of entry for processing:180109
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150118120B

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[PMID]: 28042654
[Au] Autor:Bhagwat NM; Tayde PS; Dalwadi PP; Sorabjee J; Varthakavi PK
[Ad] Address:Department of Endocrinology, B.Y.L Nair Charitable Hospital & Topiwala National Medical College, Mumbai-400008, India. bhagwatnik@yahoo.co.in.
[Ti] Title:Mikulicz's Disease with hypophysitis - a new IgG4-mediated disorder.
[So] Source:Endokrynol Pol;67(6):622-626, 2016.
[Is] ISSN:2299-8306
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:INTRODUCTION: We present a case of Mikulicz's Disease with hypophysitis. This is a rare clinical association as part of the group of IgG4- related diseases, a group of disorders which can have multiorgan involvement. METHODS: A 55-year-old male patient was diagnosed with Mikulicz's disease. He was treated with oral steroids for six months with complete resolution. After two years the patient presented with fatigue, generalised weakness, and weight loss of 11 kg over six months. On evaluation he was found to have panhypopituitarism. MRI pituitary revealed homogeneously enlarged, well enhancing pituitary with thickening of the stalk. Serum IgG4 levels were significantly elevated. The patient was treated with methyl prednisolone pulse therapy followed by oral steroids for three months. He developed diabetes insipidus after starting steroid therapy. There was a significant resolution in the enlargement of the pituitary and stalk thickening at three months. RESULTS: The clinical, biochemical, and radiological findings of hypophysitis associated with Mikulicz's disease are presented with a brief review of literature. CONCLUSIONS: IgG4-related diseases are rare and have recently been recognised as a cause of hypophysitis. They can have multiorgan involvement. A high index of suspicion is required for clinching this rare diagnosis, which can be confirmed by measurement of serum levels of IgG4. Steroid therapy can reverse the inflammatory changes in IgG4 hypophysitis. (Endokrynol Pol 2016; 67 (6): 622-626).
[Mh] MeSH terms primary: Autoimmune Hypophysitis/complications
Hypopituitarism/etiology
Mikulicz´ Disease/complications
Pituitary Gland/drug effects
[Mh] MeSH terms secundary: Anti-Inflammatory Agents/therapeutic use
Autoimmune Hypophysitis/diagnosis
Autoimmune Hypophysitis/drug therapy
Humans
Hypopituitarism/diagnosis
Hypopituitarism/drug therapy
Male
Methylprednisolone/therapeutic use
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Inflammatory Agents); X4W7ZR7023 (Methylprednisolone)
[Em] Entry month:1704
[Cu] Class update date: 170420
[Lr] Last revision date:170420
[Js] Journal subset:IM
[Da] Date of entry for processing:170103
[St] Status:MEDLINE
[do] DOI:10.5603/EP.2016.0071

  3 / 328 MEDLINE  
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[PMID]: 27987516
[Au] Autor:Liu AC; Chen Y; Jia JS; Gao SY; Liu YY
[Ad] Address:Department of Kidney, Peking University People's Hospital, Beijing 100044, China.
[Ti] Title:[Non-Hodgkin's lymphoma mimicking Mikulicz disease: a case report].
[So] Source:Beijing Da Xue Xue Bao Yi Xue Ban;48(6):1074-1076, 2016 12 18.
[Is] ISSN:1671-167X
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:IgG4-related disease is a systemic disorder involving a spectrum of multiple indications, and various histopathological features are shared among different IgG4-related disease subtypes, which challenge diagnosis, although certain syndromes have organ-specific involvement. Among them, Mikulicz's disease affecting the salivary and lacrimal glands, distinguished by often elevated levels of serum IgG4, infiltration of IgG4 plasma cells into target tissues, and diffuse swelling, mass formation, or fibrosis of affected organs. However, there are several diseases, which could manifest as salivary gland swelling, mimicking Mikulicz's disease, such as Sjogren's syndrome, mumps virus infection, obstruction of parotid duct, non-Hodgkin's lymphoma (NHL), and so on. So differential diagnosis is important and essential as to the salivary gland swelling. In this paper, we analyzed a case of a 59-year-old male with symmetric salivary gland swelling. Mikulicz's disease was misdiagnosed at the beginning without biopsy. Prednisone treatment ever seemed to be effective and antibiotics had no effect. Besides salivary involvement, the patient also manifested as testicle swelling and severe pancytopenia with the development of the disease, which rarely appeared in Mikulicz's disease. Physical examination showed skin, sclera yellow dye, swollen submandibular, sublingual and lacrimal gland and splenomegaly. As a result, biopsy of right submandibular gland was made, and mucosa-associated lymphoid tissue lymphoma was confirmed by morphology and immunohistochemistry. Bone marrow biopsy also confirmed that lymphoma cells were found in the bone marrow. Finally, the diagnosis of mucosa-associated lymphoid tissue lymphoma (Phase IVE, Group A) was made on the patient, who was transferred to the hematology department for the treatment. NHL, especially, primary extranodal lymphoma usually involves the salivary gland, and painless swelling of the salivary gland is a common manifestation, similar with Mikulicz's disease. So although salivary gland swelling is often associated with autoimmune diseases such as Sjogren's syndrome and IgG4-related disease, the awareness and suspicion of a possibility of NHL are essential for rheumatologists. Biopsy is a necessary examination to decrease or avoid misdiagnosis.
[Mh] MeSH terms primary: Lymphoma, B-Cell, Marginal Zone/diagnosis
[Mh] MeSH terms secundary: Autoimmune Diseases/diagnosis
Biopsy
Bone Marrow Examination
Diagnosis, Differential
Edema/etiology
Fibrosis
Humans
Immunoglobulin G/immunology
Immunohistochemistry
Lacrimal Apparatus/immunology
Lacrimal Apparatus/pathology
Lymphoma, B-Cell, Marginal Zone/pathology
Lymphoma, B-Cell, Marginal Zone/physiopathology
Male
Middle Aged
Mikulicz' Disease/diagnosis
Pancytopenia/etiology
Salivary Glands/immunology
Salivary Glands/pathology
Splenomegaly/etiology
Submandibular Gland
Testis/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunoglobulin G)
[Em] Entry month:1708
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:161218
[St] Status:MEDLINE

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[PMID]: 27795505
[Au] Autor:Nanke Y; Kobashigawa T; Yago T; Kawamoto M; Yamanaka H; Kotake S
[Ad] Address:Institute of Rheumatology, Tokyo Women's Medical University.
[Ti] Title:Detection of IFN-γ+IL-17+ cells in salivary glands of patients with Sjögren's syndrome and Mikulicz's disease: Potential role of Th17•Th1 in the pathogenesis of autoimmune diseases.
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;39(5):473-477, 2016.
[Is] ISSN:1349-7413
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:  Objective: Th17 cells, which mainly produce interleukin (IL)-17, have been suggested to play a critical role in the pathogenesis of autoimmune diseases. The plasticity of Th17 cells, in which these cells shift to a Th1 phenotype in the presence of IL-12, has recently been reported. However, the role of IL-17 in Sjögren's syndrome (SS) and Mikulicz's disease (MD) currently remains unknown. PATIENTS AND METHODS: The submandibular salivary gland and lymph node of a MD patient and the salivary glands of 15 SS patients were collected. IFN-γ+ cells, IL-17+ cells, and IFN-γ+IL-17+ cells were detected by immunohistochemical staining. RESULTS: IFN-γ+ cells, IL-17+ cells, and IFN-γ+IL-17+ cells were detected in the submandibular salivary gland and lymph node of the MD patient and salivary glands of the 15 SS patients. DISCUSSION: IFN-γ+IL-17+cells in the salivary glands of patients were speculated to be Th1/Th17 cells in the present study. Th1/Th17 cells are known to be derived from Th17 cells and differentiate into Th1 cells, and IL-17-derived Th1 cells have been suggested to induce the deterioration of juvenile idiopathic arthritis (JIA). Thus, Th1/Th17 cells may play an important role in the pathogenesis of SS and MD. CONCLUSION: IFN-γ+, IFN-γ+IL-17+, and IL-17+ cells were detected in the submandibular salivary gland and lymph node of a MD patient and the salivary glands of 15 SS patients.
[Mh] MeSH terms primary: Cell Plasticity/immunology
Mikulicz´ Disease/immunology
Salivary Glands/cytology
Salivary Glands/immunology
Sjogren´s Syndrome/immunology
Th1 Cells/immunology
Th17 Cells/immunology
[Mh] MeSH terms secundary: Adult
Aged
Arthritis, Juvenile/immunology
Arthritis, Juvenile/pathology
Cell Differentiation
Female
Humans
Immunohistochemistry
Interferon-gamma/biosynthesis
Interleukin-12/immunology
Interleukin-17/biosynthesis
Lymph Nodes/cytology
Lymph Nodes/immunology
Middle Aged
Mikulicz' Disease/pathology
Sjogren's Syndrome/pathology
Th17 Cells/cytology
Th17 Cells/metabolism
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Interleukin-17); 187348-17-0 (Interleukin-12); 82115-62-6 (Interferon-gamma)
[Em] Entry month:1703
[Cu] Class update date: 170323
[Lr] Last revision date:170323
[Js] Journal subset:IM
[Da] Date of entry for processing:161101
[St] Status:MEDLINE

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[PMID]: 27631251
[Au] Autor:Chuang TL; Hsu BB; Chi CL; Wang YF
[Ad] Address:aDepartment of Nuclear Medicine bDepartment of Allergy, Immunology and Rheumatology cDepartment of Pathology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi dSchool of Medicine, Tzu Chi University, Hualien, Taiwan, R.O.C.
[Ti] Title:Gallium SPECT/CT in evaluation of IgG4-related disease: A case report and literature review.
[So] Source:Medicine (Baltimore);95(37):e4865, 2016 Sep.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The clinical picture of IgG4-related sclerosing disease (IgG4-RSD) may mimic lymphoma, and should be in the differential diagnosis of patients with this clinical picture. CASE SUMMARY: A 32-year-old female had recurrent swelling of both eyelids for more than 15 years. Examination revealed elastic, firm, swollen lacrimal glands about 2-3 cm in diameter that was not painful. Head and orbits magnetic resonance imaging (MRI) showed mass lesions over the bilateral lacrimal glands, submandibular glands, and left foramen of ovale. The differential diagnosis included lymphoid tissue, inflammatory masses, and lymphoma. Gallium single-photon emission computed tomography/computed tomography (SPECT/CT) showed uptake in the bilateral lacrimal glands, right parotid and bilateral submandibular glands, bilateral perirenal region, mediastinal, prevertebral, paraaortic, lumbar, bilateral pelvic (including internal iliac chain) lymph nodes, anterior aspect of right 3rd rib, and lateral aspect of left 6th rib. CT showed multiple enlarged lymph nodes in the mediastinum, right pulmonary hilum, prevertebral space of the thoracolumbar spine, retroperitoneal paraaortic area, bilateral parailiac areas, and bilateral perirenal spaces. Antinuclear and anti-SSA/SSB antibodies were negative, and the serum IgG4 level was 740 mg/dL (normal, 8-140 mg/dL). Right parotid gland biopsy showed abundant IgG4-positive plasma cells. Mikulicz disease (IgG4-related sclerosing disease) was diagnosed and she received glucocorticoid treatment. Follow-up CT and MRI showed with resolved eyelid swelling and perirenal mass lesions. Follow-up gallium scan was normal. CONCLUSION: Gallium SPECT/CT can be a useful tool for initial and follow-up evaluation of IgG4-RSD.
[Mh] MeSH terms primary: Mikulicz´ Disease/diagnostic imaging
Single Photon Emission Computed Tomography Computed Tomography
[Mh] MeSH terms secundary: Adult
Female
Humans
Immunoglobulin G/blood
Mikulicz' Disease/blood
Mikulicz' Disease/immunology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Immunoglobulin G)
[Em] Entry month:1702
[Cu] Class update date: 170428
[Lr] Last revision date:170428
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:160916
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004865

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[PMID]: 27311268
[Au] Autor:Goto H; Takahira M; Azumi A; Japanese Study Group for IgG4-Related Ophthalmic Disease
[Ti] Title:[Diagnostic Criteria for IgG4-related Ophthalmic Disease].
[So] Source:Nippon Ganka Gakkai Zasshi;120(5):365-8, 2016 May.
[Is] ISSN:0029-0203
[Cp] Country of publication:Japan
[La] Language:jpn
[Mh] MeSH terms primary: Eye Diseases/diagnosis
Immunoglobulin G
[Mh] MeSH terms secundary: Humans
Immunoglobulin G/analysis
Mikulicz' Disease/diagnosis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunoglobulin G)
[Em] Entry month:1607
[Cu] Class update date: 160617
[Lr] Last revision date:160617
[Js] Journal subset:IM
[Da] Date of entry for processing:160618
[St] Status:MEDLINE

  7 / 328 MEDLINE  
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[PMID]: 26849056
[Au] Autor:Li J; Ge X; Wang X; Liu X; Ma J
[Ad] Address:Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
[Ti] Title:Complement System in the Pathogenesis of Benign Lymphoepithelial Lesions of the Lacrimal Gland.
[So] Source:PLoS One;11(2):e0148290, 2016.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: We aimed to examine the potential involvement of local complement system gene expression in the pathogenesis of benign lymphoepithelial lesions (BLEL) of the lacrimal gland. METHODS: We collected data from 9 consecutive pathologically confirmed patients with BLEL of the lacrimal gland and 9 cases with orbital cavernous hemangioma as a control group, and adopted whole genome microarray to screen complement system-related differential genes, followed by RT-PCR verification and in-depth enrichment analysis (Gene Ontology analysis) of the gene sets. RESULTS: The expression of 14 complement system-related genes in the pathologic tissue, including C2, C3, ITGB2, CR2, C1QB, CR1, ITGAX, CFP, C1QA, C4B|C4A, FANCA, C1QC, C3AR1 and CFHR4, were significantly upregulated while 7 other complement system-related genes, C5, CFI, CFHR1|CFH, CFH, CD55, CR1L and CFD were significantly downregulated in the lacrimal glands of BLEL patients. The microarray results were consistent with RT-PCR analysis results. Immunohistochemistry analysis of C3c and C1q complement component proteins in the resected tissue were positive in BLEL patients, while the control group had negative expression of these proteins. Gene ontology (GO) analysis revealed that activation of the genes of complement system-mediated signaling pathways were the most enriched differential gene group in BLEL patients. CONCLUSIONS: Local expression of complement components is prominently abnormal in BLEL, and may well play a role in its pathogenesis.
[Mh] MeSH terms primary: Complement System Proteins/genetics
Gene Expression Regulation
Lacrimal Apparatus/metabolism
Mikulicz´ Disease/etiology
Mikulicz´ Disease/genetics
[Mh] MeSH terms secundary: Adult
Female
Humans
Lacrimal Apparatus/pathology
Male
Middle Aged
Mikulicz' Disease/pathology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:9007-36-7 (Complement System Proteins)
[Em] Entry month:1607
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Js] Journal subset:IM
[Da] Date of entry for processing:160206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0148290

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[PMID]: 26156745
[Au] Autor:Piao Y; Wang C; Yu W; Mao M; Yue C; Liu H; Zhang L
[Ad] Address:Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
[Ti] Title:Concomitant occurrence of Mikulicz's disease and immunoglobulin G4-related chronic rhinosinusitis: a clinicopathological study of 12 cases.
[So] Source:Histopathology;68(4):502-12, 2016 Mar.
[Is] ISSN:1365-2559
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:AIMS: Concomitant occurrence of Mikulicz's disease (MD) and immunoglobulin (Ig)G4-related chronic rhinosinusitis (IgG4-related CRS) is extremely rare. We evaluated the clinicopathological features of MD patients with concomitant IgG4-related CRS (CRS-MD). METHODS AND RESULTS: Twelve CRS-MD patients were evaluated clinically and biopsy samples were taken from the lacrimal/salivary glands (n = 12) and nasal mucosa (n = 7) for assessment of IgG4-positive cells, using immunohistochemical techniques. Similarly, nine MD patients and 10 patients with common CRS were evaluated as controls. CRS-MD patients had higher serum IgG and IgG4 concentrations than MD patients (P < 0.05 for both). Lymphoplasmacytic infiltration, lymphoid follicle formation and sclerosis was prominent in the lacrimal/salivary glands in both groups; however, the magnitude of IgG4-positive plasma cells infiltration in the CRS-MD group was significantly higher compared to the MD group (P = 0.004). Similarly, evaluation of nasal mucosa revealed greater lymphocyte, plasma cell and eosinophil infiltration and lymphoid follicle formation, together with significantly higher IgG4-positive plasma cell infiltration in the CRS-MD group compared to the common CRS group (P = 0.004). CONCLUSIONS: Concomitant MD and IgG4-related CRS were characterized by a combination of IgG4-positive plasma cells infiltration in the lacrimal/salivary glands and the nasal mucosa and increased serum IgG4.
[Mh] MeSH terms primary: Mikulicz´ Disease/complications
Rhinitis/complications
Sinusitis/complications
[Mh] MeSH terms secundary: Adult
Aged
Chronic Disease
Female
Humans
Immunoglobulin G
Male
Middle Aged
Mikulicz' Disease/immunology
Mikulicz' Disease/pathology
Retrospective Studies
Rhinitis/immunology
Rhinitis/pathology
Sinusitis/immunology
Sinusitis/pathology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunoglobulin G)
[Em] Entry month:1611
[Cu] Class update date: 161230
[Lr] Last revision date:161230
[Js] Journal subset:IM
[Da] Date of entry for processing:150710
[St] Status:MEDLINE
[do] DOI:10.1111/his.12775

  9 / 328 MEDLINE  
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[PMID]: 26608265
[Au] Autor:Sarkar A; Pitchumoni CS
[Ti] Title:The protean manifestations of IgG4-RD in gastrointestinal disorders.
[So] Source:Dis Mon;61(12):493-515, 2015 Dec.
[Is] ISSN:1557-8194
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Gastrointestinal Diseases/diagnosis
Gastrointestinal Diseases/immunology
Gastrointestinal Tract/immunology
Immunoglobulin G/immunology
[Mh] MeSH terms secundary: Autoimmune Diseases/diagnosis
Autoimmune Diseases/immunology
Biliary Tract Diseases/diagnosis
Biliary Tract Diseases/immunology
Gastrointestinal Diseases/therapy
Gastrointestinal Tract/pathology
Humans
Immunoglobulin G/metabolism
Immunosuppressive Agents/therapeutic use
Liver Diseases/diagnosis
Liver Diseases/immunology
Mikulicz' Disease/diagnosis
Mikulicz' Disease/immunology
Pancreatitis/diagnosis
Pancreatitis/immunology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Immunoglobulin G); 0 (Immunosuppressive Agents)
[Em] Entry month:1605
[Cu] Class update date: 151221
[Lr] Last revision date:151221
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:151127
[St] Status:MEDLINE

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[PMID]: 26587853
[Au] Autor:Udell J
[Ti] Title:IgG4-Related Disease: Treatment and Insight Into Pathophysiology: Video of the Lecture by John Stone MD, MPH.
[So] Source:J Clin Rheumatol;21(8):426, 2015 Dec.
[Is] ISSN:1536-7355
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Glucocorticoids/therapeutic use
Immunoglobulin G/immunology
Rituximab/therapeutic use
[Mh] MeSH terms secundary: Humans
Immune System/immunology
Immune System/physiopathology
Immunohistochemistry
Immunologic Factors/therapeutic use
Mikulicz' Disease/diagnosis
Mikulicz' Disease/drug therapy
Mikulicz' Disease/immunology
Mikulicz' Disease/physiopathology
Submandibular Gland/immunology
Submandibular Gland/pathology
Tomography, X-Ray Computed/methods
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; LECTURES; VIDEO-AUDIO MEDIA
[Nm] Name of substance:0 (Glucocorticoids); 0 (Immunoglobulin G); 0 (Immunologic Factors); 4F4X42SYQ6 (Rituximab)
[Em] Entry month:1609
[Cu] Class update date: 151121
[Lr] Last revision date:151121
[Js] Journal subset:IM
[Da] Date of entry for processing:151121
[St] Status:MEDLINE
[do] DOI:10.1097/RHU.0000000000000331


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