Database : MEDLINE
Search on : necatoriasis [Words]
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[PMID]: 26672231
[Au] Autor:Zhao JH; Zhan XD; Li CP
[Ti] Title:[One case of Necator americanus infection found under gastroscope].
[So] Source:Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi;33(4):318, 2015 Aug.
[Is] ISSN:1000-7423
[Cp] Country of publication:China
[La] Language:chi
[Mh] MeSH terms primary: Gastroscopes
Necator americanus
Necatoriasis
[Mh] MeSH terms secundary: Animals
Humans
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1602
[Js] Journal subset:IM
[Da] Date of entry for processing:151217
[St] Status:MEDLINE

  2 / 360 MEDLINE  
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PubMed Central Full text
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[PMID]: 26318523
[Au] Autor:Rey-Burusco MF; Ibáñez-Shimabukuro M; Gabrielsen M; Franchini GR; Roe AJ; Griffiths K; Zhan B; Cooper A; Kennedy MW; Córsico B; Smith BO
[Ad] Address:Instituto de Investigaciones Bioquímicas de La Plata, CONICET-UNLP, Facultad de Ciencias Médicas, calles 60 y 120, 1900-La Plata, Argentina....
[Ti] Title:Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus.
[So] Source:Biochem J;471(3):403-14, 2015 Nov 1.
[Is] ISSN:1470-8728
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Fatty acid and retinol-binding proteins (FARs) comprise a family of unusual α-helix rich lipid-binding proteins found exclusively in nematodes. They are secreted into host tissues by parasites of plants, animals and humans. The structure of a FAR protein from the free-living nematode Caenorhabditis elegans is available, but this protein [C. elegans FAR-7 (Ce-FAR-7)] is from a subfamily of FARs that does not appear to be important at the host/parasite interface. We have therefore examined [Necator americanus FAR-1 (Na-FAR-1)] from the blood-feeding intestinal parasite of humans, N. americanus. The 3D structure of Na-FAR-1 in its ligand-free and ligand-bound forms, determined by NMR (nuclear magnetic resonance) spectroscopy and X-ray crystallography respectively, reveals an α-helical fold similar to Ce-FAR-7, but Na-FAR-1 possesses a larger and more complex internal ligand-binding cavity and an additional C-terminal α-helix. Titration of apo-Na-FAR-1 with oleic acid, analysed by NMR chemical shift perturbation, reveals that at least four distinct protein-ligand complexes can be formed. Na-FAR-1 and possibly other FARs may have a wider repertoire for hydrophobic ligand binding, as confirmed in the present study by our finding that a range of neutral and polar lipids co-purify with the bacterially expressed recombinant protein. Finally, we show by immunohistochemistry that Na-FAR-1 is present in adult worms with a tissue distribution indicative of possible roles in nutrient acquisition by the parasite and in reproduction in the male.
[Mh] MeSH terms primary: Host-Parasite Interactions
Necator americanus/metabolism
Necatoriasis/metabolism
Retinol-Binding Proteins/metabolism
[Mh] MeSH terms secundary: Animals
Binding Sites
Caenorhabditis elegans/metabolism
Caenorhabditis elegans/pathogenicity
Caenorhabditis elegans Proteins/chemistry
Caenorhabditis elegans Proteins/metabolism
Carrier Proteins/chemistry
Carrier Proteins/metabolism
Fatty Acids/chemistry
Fatty Acids/metabolism
Ligands
Necator americanus/chemistry
Necator americanus/pathogenicity
Necatoriasis/parasitology
Reproduction
Retinol-Binding Proteins/chemistry
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Caenorhabditis elegans Proteins); 0 (Carrier Proteins); 0 (FAR protein, C elegans); 0 (Fatty Acids); 0 (Ligands); 0 (Retinol-Binding Proteins)
[Em] Entry month:1601
[Cu] Class update date: 151222
[Lr] Last revision date:151222
[Js] Journal subset:IM
[Da] Date of entry for processing:151017
[St] Status:MEDLINE
[do] DOI:10.1042/BJ20150068

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[PMID]: 25926209
[Au] Autor:Reyes-Leiva BA; De León JL; Castellanos F; Sandoval E; García-Martínez I
[Ad] Address:Department of Gastroenterology, Department of Internal Medicine, Roosevelt Hospital, Guatemala City, Guatemala....
[Ti] Title:Obscure overt gastrointestinal bleeding due to Necator americanus diagnosed by double-balloon enteroscopy.
[So] Source:Endoscopy;47 Suppl 1 UCTN:E57, 2015.
[Is] ISSN:1438-8812
[Cp] Country of publication:Germany
[La] Language:eng
[Mh] MeSH terms primary: Double-Balloon Enteroscopy
Gastrointestinal Hemorrhage/parasitology
Ileal Diseases/parasitology
Jejunal Diseases/parasitology
Necator americanus/isolation & purification
Necatoriasis/diagnosis
[Mh] MeSH terms secundary: Animals
Female
Humans
Middle Aged
Necatoriasis/complications
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1601
[Js] Journal subset:IM
[Da] Date of entry for processing:150430
[St] Status:MEDLINE
[do] DOI:10.1055/s-0034-1390723

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[PMID]: 25745677
[Ti] Title:Soil-transmitted helminthiases: number of children treated in 2013.
[So] Source:Wkly Epidemiol Rec;90(10):89-94, 2015 Mar 6.
[Is] ISSN:0049-8114
[Cp] Country of publication:Switzerland
[La] Language:eng; fre
[Mh] MeSH terms primary: Ancylostomiasis/prevention & control
Anthelmintics/therapeutic use
Ascariasis/prevention & control
Necatoriasis/prevention & control
Primary Prevention/statistics & numerical data
Trichuriasis/prevention & control
[Mh] MeSH terms secundary: Adolescent
Albendazole/therapeutic use
Ancylostoma
Ancylostomiasis/transmission
Animals
Ascariasis/transmission
Ascaris lumbricoides
Child
Child, Preschool
Databases, Factual/statistics & numerical data
Global Health
Humans
Infant
Mebendazole/therapeutic use
Necator americanus
Necatoriasis/transmission
Soil/parasitology
Trichuriasis/transmission
Trichuris
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthelmintics); 0 (Soil); 81G6I5V05I (Mebendazole); F4216019LN (Albendazole)
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:150306
[St] Status:MEDLINE

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Clinical Trials Registry
PubMed Central Full text
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[PMID]: 24795483
[Au] Autor:Cantacessi C; Giacomin P; Croese J; Zakrzewski M; Sotillo J; McCann L; Nolan MJ; Mitreva M; Krause L; Loukas A
[Ad] Address:Department of Veterinary Medicine, University of Cambridge, United Kingdom Australian Institute of Tropical Health and Medicine, Queensland Tropical Health Alliance Laboratory, James Cook University, Cairns....
[Ti] Title:Impact of experimental hookworm infection on the human gut microbiota.
[So] Source:J Infect Dis;210(9):1431-4, 2014 Nov 1.
[Is] ISSN:1537-6613
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The interactions between gastrointestinal parasitic helminths and commensal bacteria are likely to play a pivotal role in the establishment of host-parasite cross-talk, ultimately shaping the development of the intestinal immune system. However, little information is available on the impact of infections by gastrointestinal helminths on the bacterial communities inhabiting the human gut. We used 16S rRNA gene amplification and pyrosequencing to characterize, for the first time to our knowledge, the differences in composition and relative abundance of fecal microbial communities in human subjects prior to and following experimental infection with the blood-feeding intestinal hookworm, Necator americanus. Our data show that, although hookworm infection leads to a minor increase in microbial species richness, no detectable effect is observed on community structure, diversity or relative abundance of individual bacterial species.
[Mh] MeSH terms primary: Gastrointestinal Tract/microbiology
Microbiota
Necator americanus
Necatoriasis/microbiology
[Mh] MeSH terms secundary: Animals
Feces/microbiology
Feces/parasitology
Gastrointestinal Tract/immunology
Gastrointestinal Tract/parasitology
Humans
Microbiota/physiology
Necatoriasis/immunology
[Pt] Publication type:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1412
[Cu] Class update date: 150806
[Lr] Last revision date:150806
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:141014
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jiu256

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[PMID]: 24968666
[Au] Autor:Phuphisut O; Yoonuan T; Sanguankiat S; Chaisiri K; Maipanich W; Pubampen S; Komalamisra C; Adisakwattana P
[Ti] Title:Triplex polymerase chain reaction assay for detection of major soil-transmitted helminths, Ascaris lumbricoides, Trichuris trichiura, Necator americanus, in fecal samples.
[So] Source:Southeast Asian J Trop Med Public Health;45(2):267-75, 2014 Mar.
[Is] ISSN:0125-1562
[Cp] Country of publication:Thailand
[La] Language:eng
[Ab] Abstract:Ascaris lumbricoides, Trichuris trichiura, and Necator americanus are medically important soil-transmitted helminths (STHs) occurring frequently worldwide including Thailand. Fecal examination using a microscope has been recommended as the gold standard for diagnosis of STH infections, but suffers from low sensitivity. Recently, highly sensitive and specific assays, such as multiplex quantitative PCR, has been established, but the high cost and need for special instruments are still barriers limiting their applications in routine diagnosis. Therefore, a conventional multiplex PCR assay, with its lower cost and greater simplicity, was developed, for the simultaneous detection of STHs in fecal samples. The multiplex PCR assay was species-specific to the three STHs, and could detect one copy of DNA target. Compared with microscopic examination of fecal samples, sensitivity and specificity of the multiplex PCR was 87% and 83%, respectively. This multiplex PCR assay provides an alternative method for routine diagnosis of STHs infection, and might be applied for epidemiological studies of STHs in endemic areas.
[Mh] MeSH terms primary: Ascariasis/diagnosis
Multiplex Polymerase Chain Reaction
Necatoriasis/diagnosis
Soil/parasitology
Trichuriasis/diagnosis
[Mh] MeSH terms secundary: Animals
Ascariasis/parasitology
Ascaris lumbricoides/isolation & purification
Feces/parasitology
Humans
Necator americanus/isolation & purification
Necatoriasis/pathology
Sensitivity and Specificity
Thailand
Trichuriasis/parasitology
Trichuris/isolation & purification
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Soil)
[Em] Entry month:1407
[Js] Journal subset:IM
[Da] Date of entry for processing:140627
[St] Status:MEDLINE

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[PMID]: 24797001
[Ti] Title:Image of the month: Hookworm infection observed via a narrow-band imaging system.
[So] Source:Am J Gastroenterol;109(5):626, 2014 May.
[Is] ISSN:1572-0241
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Duodenoscopy
Narrow Band Imaging
Necator americanus/isolation & purification
Necatoriasis/diagnosis
[Mh] MeSH terms secundary: Adult
Animals
Humans
Male
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1406
[Js] Journal subset:IM
[Da] Date of entry for processing:140506
[St] Status:MEDLINE
[do] DOI:10.1038/ajg.2014.96

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[PMID]: 24631931
[Au] Autor:Mason L; Tribolet L; Simon A; von Gnielinski N; Nienaber L; Taylor P; Willis C; Jones MK; Sternberg PW; Gasser RB; Loukas A; Hofmann A
[Ad] Address:Structural Chemistry Program, Eskitis Institute, Griffith University, Brisbane, Queensland, Australia....
[Ti] Title:Probing the equatorial groove of the hookworm protein and vaccine candidate antigen, Na-ASP-2.
[So] Source:Int J Biochem Cell Biol;50:146-55, 2014 May.
[Is] ISSN:1878-5875
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Hookworm activation-associated secreted proteins can be structurally classified into at least three different groups. The hallmark feature of Group 1 activation-associated secreted proteins is a prominent equatorial groove, which is inferred to form a ligand binding site. Furthermore, a conserved tandem histidine motif is located in the centre of the groove and believed to provide or support a yet to be determined catalytic activity. Here, we report three-dimensional crystal structures of Na-ASP-2, an L3-secreted activation-associated secreted protein from the human hookworm Necator americanus, which demonstrate transition metal binding ability of the conserved tandem histidine motif. We further identified moderate phosphohydrolase activity of recombinant Na-ASP-2, which relates to the tandem histidine motif. By panning a random 12-mer peptide phage library, we identified a peptide with high similarity to the human calcium-activated potassium channel SK3, and confirm binding of the synthetic peptide to recombinant Na-ASP-2 by differential scanning fluorimetry. Potential binding modes of the peptide to Na-ASP-2 were studied by molecular dynamics simulations which clearly identify a preferred topology of the Na-ASP-2:SK3 peptide complex.
[Mh] MeSH terms primary: Antigens, Helminth/chemistry
Helminth Proteins/chemistry
Necator americanus/metabolism
Necatoriasis/parasitology
Vaccines/chemistry
[Mh] MeSH terms secundary: Animals
Antigens, Helminth/immunology
Antigens, Helminth/metabolism
Binding Sites
Crystallography, X-Ray
Helminth Proteins/immunology
Helminth Proteins/metabolism
Models, Molecular
Necator americanus/chemistry
Necator americanus/isolation & purification
Phosphoric Monoester Hydrolases/chemistry
Phosphoric Monoester Hydrolases/metabolism
Protein Structure, Tertiary
Vaccines/immunology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antigens, Helminth); 0 (Helminth Proteins); 0 (Vaccines); EC 3.1.3.- (Phosphoric Monoester Hydrolases)
[Em] Entry month:1507
[Js] Journal subset:IM
[Da] Date of entry for processing:140415
[St] Status:MEDLINE

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[PMID]: 24493672
[Au] Autor:Gunawardena S; Gunawardena NK; Kahathuduwa G; Karunaweera ND; de Silva NR; Ranasinghe UB; Samarasekara SD; Nagodavithana KC; Rao RU; Rebollo MP; Weil GJ
[Ad] Address:Department of Parasitology, Faculty of Medicine, University of Colombo, Sri Lanka; Department of Parasitology, Faculty of Medicine, University of Kelaniya, Sri Lanka; Anti Filariasis Campaign, Ministry of Health, Sri Lanka; Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St. Louis, Missouri; Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, United Kingdom.
[Ti] Title:Integrated school-based surveillance for soil-transmitted helminth infections and lymphatic filariasis in Gampaha district, Sri Lanka.
[So] Source:Am J Trop Med Hyg;90(4):661-6, 2014 Apr.
[Is] ISSN:1476-1645
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We explored the practicality of integrating surveillance for soil-transmitted helminthiasis (STH, assessed by Kato-Katz) with transmission assessment surveys for lymphatic filariasis (LF) in two evaluation units (EUs) in Gampaha district, Sri Lanka (population 2.3 million). The surveys were performed 6 years after five annual rounds of mass drug administration with diethylcarbamazine and albendazole. Each transmission assessment survey tested children (N = 1,462 inland EU; 1,642 coastal EU) sampled from 30 primary schools. Low filarial antigenemia rates (0% and 0.1% for the inland and coastal EUs) suggest that LF transmission is very low in this district. The STH rates and stool sample participation rates were 0.8% and 61% (inland) and 2.8% and 58% (coastal). Most STH detected were low or moderate intensity Trichuris trichiura infections. The added cost of including STH testing was ∼$5,000 per EU. These results suggest that it is feasible to integrate school-based surveillance for STH and LF.
[Mh] MeSH terms primary: Antigens, Helminth/immunology
Elephantiasis, Filarial/epidemiology
Epidemiological Monitoring
Helminthiasis/epidemiology
School Health Services
[Mh] MeSH terms secundary: Animals
Ascariasis/epidemiology
Ascariasis/immunology
Ascariasis/transmission
Ascaris lumbricoides/immunology
Child
Elephantiasis, Filarial/immunology
Elephantiasis, Filarial/transmission
Feasibility Studies
Feces/parasitology
Helminthiasis/immunology
Helminthiasis/transmission
Humans
Necator americanus/immunology
Necatoriasis/epidemiology
Necatoriasis/immunology
Necatoriasis/transmission
Parasite Egg Count
School Health Services/economics
Soil/parasitology
Sri Lanka/epidemiology
Trichuriasis/epidemiology
Trichuriasis/immunology
Trichuriasis/transmission
Trichuris/immunology
Wuchereria bancrofti/immunology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antigens, Helminth); 0 (Soil)
[Em] Entry month:1405
[Cu] Class update date: 150515
[Lr] Last revision date:150515
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:140403
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.13-0641

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[PMID]: 24676818
[Au] Autor:Inoue K; Ozaka S; Okamoto K; Ogawa R; Mizukami K; Okimoto T; Kodama M; Kobayashi T; Eshita Y; Hasegawa H; Murakami K
[Ad] Address:Department of Gastroenterology, Almeida Hospital, Oita, Japan....
[Ti] Title:Multiple infections with helminths--whipworm, hookworm, and roundworm.
[So] Source:Endoscopy;46 Suppl 1 UCTN:E117-8, 2014.
[Is] ISSN:1438-8812
[Cp] Country of publication:Germany
[La] Language:eng
[Mh] MeSH terms primary: Ascariasis/complications
Ascaris lumbricoides
Coinfection/parasitology
Necator americanus
Necatoriasis/complications
Trichuriasis/complications
Trichuris
[Mh] MeSH terms secundary: Aged, 80 and over
Anemia/etiology
Animals
Ascariasis/diagnosis
Endoscopy, Gastrointestinal
Female
Humans
Necatoriasis/diagnosis
Trichuriasis/diagnosis
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Entry month:1411
[Js] Journal subset:IM
[Da] Date of entry for processing:140328
[St] Status:MEDLINE
[do] DOI:10.1055/s-0034-1364887


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