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[PMID]: 25827535
[Au] Autor:Cornejo KM; Lu M; Yang P; Wu S; Cai C; Zhong WD; Olumi A; Young RH; Wu CL
[Ad] Address:James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA; Department of Pathology, Harvard Medical School, Boston, MA....
[Ti] Title:Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma.
[So] Source:Hum Pathol;46(6):820-6, 2015 Jun.
[Is] ISSN:1532-8392
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Succinate dehydrogenase B (SDHB) is a mitochondrial enzyme complex subunit. Loss of SDHB protein expression has been found to correlate with SDHx gene mutations. Little is known about its expression in subtypes of renal cell carcinoma (RCC) and whether it is a prognostic indicator. Four hundred fifty renal epithelial neoplasms were analyzed for SDHB, comprising clear cell RCC (CCRCC) (n = 240), papillary RCC (n = 84), chromophobe RCC (n = 49), renal oncocytoma (n = 47), clear cell papillary RCC (CCPRCC) (n = 19), and von Hippel-Lindau (VHL)-associated CCPRCC-like tumors (n = 11). Succinate dehydrogenase B expression was graded based upon staining intensity using a 4-tiered system (0-3+), in which 3+ was strongest and complete absence was 0. Neoplasms were further categorized based upon staining extent into SDHB weak (1+-2+) and strong (3+). Succinate dehydrogenase B was strongly preserved in 131 (55%) of 240 CCRCCs, 84 (100%) of 84 papillary RCCs, 49 (100%) of 49 chromophobe RCCs, 1 (5%) of 19 CCPRCC, 5 (45%) of 11 VHL-associated CCPRCC-like tumors, and 47 (100%) of 47 renal oncocytomas. The remaining 109 CCRCCs, 18 CCPRCCs, and 6 VHL-associated CCPRCC-like tumors had weak but preserved SDHB. Succinate dehydrogenase B expression in CCRCCs with high International Society of Urological Pathology nucleolar grade (G3-G4) correlated significantly with survival (log-rank, P = .0004). Succinate dehydrogenase B is variably expressed in RCCs with clear cell morphology and strongly preserved in most other neoplasms. Therefore, weak staining, particularly in clear neoplasms, should not be misinterpreted as negative. Finally, SDHB expression in CCRCCs with high nucleolar grade (G3-G4) is significantly associated with survival, indicating it may be both a diagnostic and prognostic marker in RCC.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 1966281 MEDLINE  
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[PMID]: 25949851
[Au] Autor:Moore KA; Bohnstedt BN; Shah SU; Abdulkader MM; Bonnin JM; Ackerman LL; Shaikh KA; Kralik SF; Shah MV
[Ad] Address:Goodman Campbell Brain and Spine, Department of Neurological Surgery, Indiana University School of Medicine, 355 W. 16 Street, Suite 5100, Indianapolis, IN, USA....
[Ti] Title:Intracranial chordoma presenting as acute hemorrhage in a child: Case report and literature review.
[So] Source:Surg Neurol Int;6:63, 2015.
[Is] ISSN:2229-5097
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:BACKGROUND: Chordomas are rare, slow-growing malignant neoplasms derived from remnants of the embryological notochord. Pediatric cases comprise only 5% of all chordomas, but more than half of the reported pediatric chordomas are intracranial. For patients of all ages, intracranial chordomas typically present with symptoms such as headaches and progressive neurological deficits occurring over several weeks to many years as they compress or invade local structures. There are only reports of these tumors presenting acutely with intracranial hemorrhage in adult patients. CASE DESCRIPTION: A 10-year-old boy presented with acute onset of headache, emesis, and diplopia. Head computed tomography and magnetic resonance imaging of brain were suspicious for a hemorrhagic mass located in the left petroclival region, compressing the ventral pons. The mass was surgically resected and demonstrated acute intratumoral hemorrhage. Pathologic examination was consistent with chordoma. CONCLUSION: There are few previous reports of petroclival chordomas causing acute intracranial hemorrhage. To the authors' knowledge, this is the first case of a petroclival chordoma presenting as acute intracranial hemorrhage in a pediatric patient. Although uncommon, it is important to consider chordoma when evaluating a patient of any age presenting with a hemorrhagic lesion of the clivus.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Da] Date of entry for processing:150507
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/2152-7806.155445

  3 / 1966281 MEDLINE  
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[PMID]: 25948994
[Au] Autor:Rastogi V; Sharma R; Misra SR; Yadav L
[Ad] Address:Department of Oral Pathology, Kalka Dental College and Hospital, Meerut, Uttar Pradesh, India....
[Ti] Title:Diagnostic procedures for autoimmune vesiculobullous diseases: A review.
[So] Source:J Oral Maxillofac Pathol;18(3):390-7, 2014 Sep-Dec.
[Is] ISSN:0973-029X
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Oral soft tissues are affected by numerous pathologic conditions of variable etiology and hence their appropriate management relies on their accurate diagnosis. Clinical identification of intact vesicle and bulla in the oral cavity is really a challenge due to the regular irritation and the friable nature of oral mucosa. Rupture of these lesions leads to erosions or ulcerations on the surface, hence making the diagnosis of vesiculobullous (VB) lesions is even more difficult due to the fact that the differential diagnosis along with VB lesions will also include ulcerative, immunological-mediated diseases, and neoplasms and systemic diseases. Hence, knowledge of the clinical presentation of these disorders and the relevant diagnostic procedures is important not just for dermatologists, but also for general practitioners and dentists. In this article, the various procedures have been explained that can be used for the diagnostic purpose of VB lesions.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1505
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Da] Date of entry for processing:150507
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/0973-029X.151324

  4 / 1966281 MEDLINE  
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[PMID]: 25948992
[Au] Autor:Satpathy Y; Spadigam AE; Dhupar A; Syed S
[Ad] Address:Department of Oral and Maxillofacial Pathology, Goa Dental College and Hospital, Bambolim, Goa, India....
[Ti] Title:Epithelial and stromal patterns of pleomorphic adenoma of minor salivary glands: A histopathological and histochemical study.
[So] Source:J Oral Maxillofac Pathol;18(3):379-85, 2014 Sep-Dec.
[Is] ISSN:0973-029X
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:BACKGROUND: Pleomorphic adenoma (PA) accounts for 45-74% of all the salivary gland neoplasms, of which 40-70% are present in minor salivary glands. Studies have depicted variations in histological typing and classification of these tumors. Its pleomorphism is attributed to the cytological differentiations of the epithelial components and the diverse stromal components. Biochemical investigations of saliva have revealed "mucins" to be its main component. Mucins reflect in their composition, the functional state of the mucosa, both in health and disease. Many reviews on histochemical classification and identification have been put forward to explain the intricacies of mucins; however, no attempts have been made to classify salivary gland tumors based on their mucin profiles and assess its prognostic significance. Thus, this study was executed to analyze the clinical, histopathological and histochemical behavior of PA of minor salivary glands and decipher a correlation. MATERIALS AND METHODS: Twenty-six diagnosed cases of PA of minor salivary glands and five controls of normal minor salivary glands of the hard palate were included in the study. Blocks were retrieved, sectioned and stained with hematoxylin and eosin (H and E) stain as well as combined Alcian blue (AB)-periodic acid-Schiff (PAS) stains. RESULTS: The stained slides revealed an array of epithelial and stromal patterns and varying heterogeneity of mucin expression of normal and neoplastic minor salivary glands. CONCLUSION: The study elucidated the role of mucins in tumorigenesis and its prognostic implications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Da] Date of entry for processing:150507
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/0973-029X.151319

  5 / 1966281 MEDLINE  
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[PMID]: 25765070
[Au] Autor:Rizvi NA; Hellmann MD; Snyder A; Kvistborg P; Makarov V; Havel JJ; Lee W; Yuan J; Wong P; Ho TS; Miller ML; Rekhtman N; Moreira AL; Ibrahim F; Bruggeman C; Gasmi B; Zappasodi R; Maeda Y; Sander C; Garon EB; Merghoub T; Wolchok JD; Schumacher TN; Chan TA
[Ad] Address:Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY, 10065, USA. chant@mskcc.org....
[Ti] Title:Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.
[So] Source:Science;348(6230):124-8, 2015 Apr 3.
[Is] ISSN:1095-9203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are revolutionizing cancer treatment. To unravel the genomic determinants of response to this therapy, we used whole-exome sequencing of non-small cell lung cancers treated with pembrolizumab, an antibody targeting programmed cell death-1 (PD-1). In two independent cohorts, higher nonsynonymous mutation burden in tumors was associated with improved objective response, durable clinical benefit, and progression-free survival. Efficacy also correlated with the molecular smoking signature, higher neoantigen burden, and DNA repair pathway mutations; each factor was also associated with mutation burden. In one responder, neoantigen-specific CD8+ T cell responses paralleled tumor regression, suggesting that anti-PD-1 therapy enhances neoantigen-specific T cell reactivity. Our results suggest that the genomic landscape of lung cancers shapes response to anti-PD-1 therapy.
[Mh] MeSH terms primary: Antibodies, Monoclonal, Humanized/therapeutic use
Antineoplastic Agents/therapeutic use
Carcinoma, Non-Small-Cell Lung/drug therapy
Carcinoma, Non-Small-Cell Lung/genetics
Drug Resistance, Neoplasm/genetics
Lung Neoplasms/drug therapy
Lung Neoplasms/genetics
Programmed Cell Death 1 Receptor/antagonists & inhibitors
[Mh] MeSH terms secundary: CD8-Positive T-Lymphocytes/immunology
Carcinoma, Non-Small-Cell Lung/immunology
Cohort Studies
DNA Repair/genetics
Disease-Free Survival
Humans
Lung Neoplasms/immunology
Mutation
Smoking/genetics
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antibodies, Monoclonal, Humanized); 0 (Antineoplastic Agents); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); DPT0O3T46P (pembrolizumab)
[Em] Entry month:1504
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[Da] Date of entry for processing:150403
[St] Status:MEDLINE
[do] DOI:10.1126/science.aaa1348

  6 / 1966281 MEDLINE  
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[PMID]: 25609723
[Au] Autor:Bouvet P; Sautereau J; Le Coustumier A; Mory F; Bouchier C; Popoff MR
[Ad] Address:Institut Pasteur, Centre National de Référence des Bactéries Anaérobies et du Botulisme, Paris, France philippe.bouvet@pasteur.fr....
[Ti] Title:Foot infection by Clostridium sordellii: case report and review of 15 cases in France.
[So] Source:J Clin Microbiol;53(4):1423-7, 2015 Apr.
[Is] ISSN:1098-660X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We report a case of foot infection by Clostridium sordellii and review 15 human infections registered at a Reference Center in France during the period 1998 to 2011. All strains were found nontoxigenic, lacking the lethal toxin gene coding for TcsL. Like Clostridium septicum, several C. sordellii infections were associated with intestinal neoplasms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1128/JCM.03414-14

  7 / 1966281 MEDLINE  
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[PMID]: 25785758
[Au] Autor:Deckard NA; Harrow BR; Barnett SL; Batra PS
[Ad] Address:Division of Otolaryngology-Head and Neck Surgery, Cooper University Hospital, Camden, New Jersey, USA.
[Ti] Title:Comparative analysis of quality-of-life metrics after endoscopic surgery for sinonasal neoplasms.
[So] Source:Am J Rhinol Allergy;29(2):151-5, 2015 Mar-Apr.
[Is] ISSN:1945-8932
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The objective of this study was to evaluate the postoperative quality of life (QOL) after endoscopic resection of sinus and skull base neoplasms using validated outcomes measures and to perform correlation of the various metrics to better discern their efficacy. Prospective QOL data collection and retrospective chart review were performed. METHODS: QOL data were collected using the 20-item Sino-Nasal Outcome Test (SNOT-20), Anterior Skull Base Questionnaire (ASBQ), European Quality-of-Life-5 Dimension (EQ-5D) questionnaire, and Lund-Kennedy endoscopic (LKE) score in 71 patients with sinonasal and skull base tumors. RESULTS: The mean age was 53 years and mean follow-up was 14.5 months at the time QOL data were collected. Benign and malignant tumors represented 39 (54.9%) and 32 (45.1%) cases, respectively. Twenty malignancies (62.5%) were stage T3 or T4, and 23 required postoperative chemotherapy and radiation (CRT). Factors indicating worsened postoperative QOL included malignant histopathology, T3 or T4 tumors, and the use of postoperative CRT (p < 0.05). There was a strong correlation of ASBQ with EQ-5D and SNOT-20 scores (r < -0.5) and a moderate correlation between the SNOT-20 and EQ-5D (r > 0.3), and the LKE had moderate correlation with SNOT-20 (r > 0.3) and weak correlation to the ASBQ (r > -0.3) and EQ-5D (r < 0.3). CONCLUSION: Patients who have undergone endoscopic resection of sinonasal tumors have quantifiable QOL changes as measured by various validated metrics. This study shows that concurrent use of these instruments may better discern QOL outcomes after endoscopic tumor surgery.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.2500/ajra.2015.29.4137

  8 / 1966281 MEDLINE  
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[PMID]: 25668818
[Au] Autor:Sabbieti MG; Agas D; Capitani M; Marchetti L; Concetti A; Vullo C; Catone G; Gabai V; Shifrin V; Sherman MY; Shneider A; Venanzi FM
[Ad] Address:School of Biosciences and Veterinary Medicine, University of Camerino, Camerino (Italy)....
[Ti] Title:Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent.
[So] Source:Oncotarget;6(6):3590-9, 2015 Feb 28.
[Is] ISSN:1949-2553
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We recently reported that a DNA plasmid coding p62-SQSTM1 acts as an effective anti tumor vaccine against both transplantable mouse tumors and canine spontaneous mammary neoplasms. Here we report the unexpected finding that intramuscular delivery of p62 DNA exerts a powerful anti-osteoporotic activity in a mouse model of inflammatory bone loss (i.e, ovariectomy) by combining bone-sparing and osteo-synthetic effects. Notably, the suppression of osteoporosis by p62DNA was associated with a sharp down-regulation of master inflammatory cytokines, and up-regulation of endogenous p62 protein by bone-marrow stromal cells. The present data provide a solid rational to apply p62 DNA vaccine as a safe, new therapeutic for treatment of inflammatory related bone loss diseases.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1503
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[St] Status:In-Process

  9 / 1966281 MEDLINE  
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[PMID]: 25780062
[Au] Autor:Betof AS; Lascola CD; Weitzel D; Landon C; Scarbrough PM; Devi GR; Palmer G; Jones LW; Dewhirst MW
[Ad] Address:Duke Cancer Institute, Duke University Medical Center, Durham, NC (ASB, CDL, DW, CL, PMS, GRD, GP, MWD); Department of Internal Medicine, Massachusetts General Hospital, Boston, MA (ASB); Memorial Sloan Kettering Cancer Center, New York, NY (LWJ)....
[Ti] Title:Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.
[So] Source:J Natl Cancer Inst;107(5), 2015 May.
[Is] ISSN:1460-2105
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Exercise has been shown to improve postischemia perfusion of normal tissues; we investigated whether these effects extend to solid tumors. Estrogen receptor-negative (ER-, 4T1) and ER+ (E0771) tumor cells were implanted orthotopically into syngeneic mice (BALB/c, N = 11-12 per group) randomly assigned to exercise or sedentary control. Tumor growth, perfusion, hypoxia, and components of the angiogenic and apoptotic cascades were assessed by MRI, immunohistochemistry, western blotting, and quantitative polymerase chain reaction and analyzed with one-way and repeated measures analysis of variance and linear regression. All statistical tests were two-sided. Exercise statistically significantly reduced tumor growth and was associated with a 1.4-fold increase in apoptosis (sedentary vs exercise: 1544 cells/mm(2), 95% CI = 1223 to 1865 vs 2168 cells/mm(2), 95% CI = 1620 to 2717; P = .048), increased microvessel density (P = .004), vessel maturity (P = .006) and perfusion, and reduced intratumoral hypoxia (P = .012), compared with sedentary controls. We also tested whether exercise could improve chemotherapy (cyclophosphamide) efficacy. Exercise plus chemotherapy prolonged growth delay compared with chemotherapy alone (P < .001) in the orthotopic 4T1 model (n = 17 per group). Exercise is a potential novel adjuvant treatment of breast cancer.
[Mh] MeSH terms primary: Cell Hypoxia/drug effects
Exercise
Mammary Neoplasms, Experimental/blood supply
Mammary Neoplasms, Experimental/drug therapy
Neovascularization, Pathologic/drug therapy
[Mh] MeSH terms secundary: Analysis of Variance
Animals
Antineoplastic Agents, Alkylating/pharmacology
Apoptosis/drug effects
Cell Line, Tumor
Cell Proliferation/drug effects
Cyclophosphamide/pharmacology
Female
Humans
Linear Models
Mammary Neoplasms, Experimental/chemistry
Mammary Neoplasms, Experimental/prevention & control
Mice
Mice, Inbred BALB C
Microcirculation/drug effects
Neoplasm Transplantation
Random Allocation
Receptors, Estrogen/analysis
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Name of substance:0 (Antineoplastic Agents, Alkylating); 0 (Receptors, Estrogen); 8N3DW7272P (Cyclophosphamide)
[Em] Entry month:1504
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[Da] Date of entry for processing:150317
[St] Status:MEDLINE

  10 / 1966281 MEDLINE  
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[PMID]: 25671300
[Au] Autor:Kaemmerer D; Reimann C; Specht E; Wirtz RM; Sayeg M; Baum RP; Schulz S; Lupp A
[Ad] Address:Department of General and Visceral Surgery, Zentralklinik Bad Berka, Bad Berka, Germany....
[Ti] Title:Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms.
[So] Source:Oncotarget;6(5):3346-58, 2015 Feb 20.
[Is] ISSN:1949-2553
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: For many tumors, the overexpression of the chemokine receptor CXCR4 is associated with increased malignancy and poor patient outcomes. However, comprehensive data for neuroendocrine neoplasms of the lung are still lacking. METHODS: CXCR4 expression was evaluated in a panel of bronchopulmonary neuroendocrine neoplasms (BP-NEN) comprising typical carcinoids (n = 26), atypical carcinoids (n = 30), and small cell lung cancers (SCLC, n = 34). Samples were analyzed by immunohistochemistry using the novel monoclonal rabbit anti-human CXCR4 antibody UMB-2 and by qRT-PCR. The expression was correlated with clinical data and overall patient survival. RESULTS: CXCR4 was predominantly localized at the plasma membrane of the tumor cells. CXCR4 was expressed with a high intensity in almost all of the 30 SCLC samples. In contrast, it was detected infrequently and with low intensity in the typical carcinoid and atypical carcinoid samples. There was a significant correlation between the immunohistochemistry and qRT-PCR data. Additionally, there was a significant negative relationship between CXCR4 expression and overall survival. CONCLUSIONS: With increasing malignancy, BP-NEN clearly differ in the extent of CXCR4 expression. As in other tumor entities, CXCR4 overexpression significantly correlates with negative patient outcome. Due to its particular high expression rate in SCLC, CXCR4 may serve as a promising new target for diagnostic and pharmacological intervention as well as for peptide receptor-based radionuclide therapy.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1503
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[St] Status:In-Process


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