Database : MEDLINE
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[PMID]: 25437583
[Au] Autor:Naitoh H; Fukasawa T; Fukuchi M; Kiriyama S; Tabe Y; Yamauchi H; Suzuki M; Yoshida T; Sakurai S; Kuwano H
[Ad] Address:1 Department of Surgery, Social Insurance Gunma Chuo General Hospital, Maebashi, Japan.
[Ti] Title:Intrahepatic biliary dilatation caused by a small simple hepatic cyst: report of a case.
[So] Source:Int Surg;99(6):753-6, 2014 Nov-Dec.
[Is] ISSN:0020-8868
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Abstract Biliary obstruction caused by small simple cysts is very rare. We present a case of biliary dilatation caused by a simple cyst with a 4-cm diameter. The patient was a 75-year-old woman referred to our hospital for evaluation of a cystic tumor associated with peripheral biliary duct dilatation in the left segment of the liver. Computed tomography and magnetic resonance imaging showed that the cyst probably communicated with the intrahepatic bile duct. Malignant tumors, including intrahepatic papillary neoplasms of the bile duct, could not be ruled out; therefore, we performed surgery with the patient's consent. Histopathologic examination of the resected liver showed that the cystic lesion was a simple cyst. The finding that even small simple cysts can obstruct the biliary tract is important for the management of cystic lesions of the liver.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Cu] Class update date: 141206
[Lr] Last revision date:141206
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.9738/INTSURG-D-13-00153.1

  2 / 1925031 MEDLINE  
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[PMID]: 25426945
[Au] Autor:Phillips-Howard PA; Laserson KF; Amek N; Beynon CM; Angell SY; Khagayi S; Byass P; Hamel MJ; van Eijk AM; Zielinski-Gutierrez E; Slutsker L; De Cock KM; Vulule J; Odhiambo FO
[Ad] Address:Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya....
[Ti] Title:Deaths Ascribed to Non-Communicable Diseases among Rural Kenyan Adults Are Proportionately Increasing: Evidence from a Health and Demographic Surveillance System, 2003-2010.
[So] Source:PLoS One;9(11):e114010, 2014.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Non-communicable diseases (NCDs) result in more deaths globally than other causes. Monitoring systems require strengthening to attribute the NCD burden and deaths in low and middle-income countries (LMICs). Data from health and demographic surveillance systems (HDSS) can contribute towards this goal. METHODS AND FINDINGS: Between 2003 and 2010, 15,228 deaths in adults aged 15 years (y) and older were identified retrospectively using the HDSS census and verbal autopsy in rural western Kenya, attributed into broad categories using InterVA-4 computer algorithms; 37% were ascribed to NCDs, 60% to communicable diseases (CDs), 3% to injuries, and <1% maternal causes. Median age at death for NCDs was 66y and 71y for females and males, respectively, with 43% (39% male, 48% female) of NCD deaths occurring prematurely among adults aged below 65y. NCD deaths were mainly attributed to cancers (35%) and cardio-vascular diseases (CVDs; 29%). The proportionate mortality from NCDs rose from 35% in 2003 to 45% in 2010 (χ2 linear trend 93.4; p<0.001). While overall annual mortality rates (MRs) for NCDs fell, cancer-specific MRs rose from 200 to 262 per 100,000 population, mainly due to increasing deaths in adults aged 65y and older, and to respiratory neoplasms in all age groups. The substantial fall in CD MRs resulted in similar MRs for CDs and NCDs among all adult females by 2010. NCD MRs for adults aged 15y to <65y fell from 409 to 183 per 100,000 among females and from 517 to 283 per 100,000 population among males. NCD MRs were higher among males than females aged both below, and at or above, 65y. CONCLUSIONS: NCDs constitute a significant proportion of deaths in rural western Kenya. Evidence of the increasing contribution of NCDs to overall mortality supports international recommendations to introduce or enhance prevention, screening, diagnosis and treatment programmes in LMICs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Cu] Class update date: 141206
[Lr] Last revision date:141206
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pone.0114010

  3 / 1925031 MEDLINE  
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[PMID]: 24613510
[Au] Autor:Pannunzio NR; Li S; Watanabe G; Lieber MR
[Ad] Address:Departments of Pathology, Biochemistry & Molecular Biology, Molecular Microbiology & Immunology, and Section of Molecular & Computational Biology, USC Norris Comprehensive Cancer Center, Rm. 5428, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, MC9176, Los ...
[Ti] Title:Non-homologous end joining often uses microhomology: implications for alternative end joining.
[So] Source:DNA Repair (Amst);17:74-80, 2014 May.
[Is] ISSN:1568-7856
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Artemis and PALF (also called APLF) appear to be among the primary nucleases involved in non-homologous end joining (NHEJ) and responsible for most nucleolytic end processing in NHEJ. About 60% of NHEJ events show an alignment of the DNA ends that use 1 or 2bp of microhomology (MH) between the two DNA termini. Thus, MH is a common feature of NHEJ. For most naturally occurring human chromosomal deletions (e.g., after oxidative damage or radiation) and translocations, such as those seen in human neoplasms and as well as inherited chromosomal structural variations, MH usage occurs at a frequency that is typical of NHEJ, and does not suggest major involvement of alternative pathways that require more extensive MH. Though we mainly focus on human NHEJ at double-strand breaks, comparison on these points to other eukaryotes, primarily S. cerevisiae, is informative.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1405
[Cu] Class update date: 141206
[Lr] Last revision date:141206
[Js] Journal subset:IM
[St] Status:In-Process

  4 / 1925031 MEDLINE  
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[PMID]: 25439443
[Au] Autor:van Sprundel RG; van den Ingh TS; Guscetti F; Kershaw O; van Wolferen ME; Rothuizen J; Spee B
[Ad] Address:Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands....
[Ti] Title:Classification of primary hepatic tumours in the cat.
[So] Source:Vet J;202(2):255-66, 2014 Nov.
[Is] ISSN:1532-2971
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Hepatic tumours in dogs have recently been re-classified to follow a revised human classification system that takes account of identified hepatic progenitor cells. This study investigated the presence and relative frequency of morphological types of feline primary hepatic neoplasms and aimed to determine whether a similar new classification scheme could be applied in cats. Feline primary liver tumours (n = 61) were examined histologically and with a series of immunohistochemical markers. Six cases of nodular hyperplasia and 21 tumours of hepatocellular origin were diagnosed. The latter were subdivided into hepatocellular tumours that were well differentiated and had no evidence of metastases (n = 18) and tumours that showed poorly differentiated areas with marked cellular and nuclear pleomorphism and had intrahepatic and, or, distant metastases (n = 3). These malignant feline hepatocellular tumours maintained their hepatocellular characteristics (HepPar-1, MRP2, pCEA positive) and were negative, or only <5% positive, for K19. Twenty-five cholangiocellular tumours were diagnosed and all had intrahepatic and, or, distant metastases. Eight NSE positive small cell carcinomas (carcinoids) were diagnosed and subdivided into small cell carcinomas with HPC characteristics (K19 positive) and neuroendocrine carcinomas (K19 negative). In addition, one squamous cell carcinoma originating from the distal part of the choledochal duct was recognised. Feline primary hepatic neoplasms can be sub-divided into benign and malignant hepatocellular tumours, cholangiocellular carcinomas, small cell carcinomas with HPC characteristics, neuroendocrine carcinomas and squamous cell carcinomas. The marked species difference justifies a specific classification for feline primary hepatic neoplasms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 1925031 MEDLINE  
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[PMID]: 25473751
[Au] Autor:Dessauvagie BF; Lai PH; Oost E; Thomas A; Stewart CJ
[Ad] Address:Department of Histopathology (B.F.D., P.H.L., C.J.R.S.), SJOG Pathology Department Anatomical Pathology, Division of Tissue Pathology (B.F.D., E.O., A.T.), PathWest Laboratory Medicine, QE II Medical Center, Nedlands, Perth Schools of Pathology and Laboratory Medicine (A.T.) Women's and Infants' Health (C.J.R.S.), University of Western Australia, WA, Australia.
[Ti] Title:Medial hypertrophy of the ovarian vein: a novel type of vascular pathology associated with a primary ovarian carcinoid tumor.
[So] Source:Int J Gynecol Pathol;34(1):36-9, 2015 Jan.
[Is] ISSN:1538-7151
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Primary carcinoid tumors of the ovary are rare accounting for only 1% of neoplasms that are associated with the carcinoid syndrome. However, the carcinoid syndrome can occur in the absence of hepatic metastases due to the release of vasoactive peptides directly into the systemic circulation via the ovarian vein. We present a 69-yr-old woman presenting with carcinoid valvular disease and congestive cardiac failure who was found to have a primary left ovarian carcinoid tumor. At operation it was noted that the left ovarian vein had an unusually firm and thickened appearance, and histologic examination revealed marked fibromuscular medial hypertrophy with luminal compression. There was no associated vascular elastosis. This ovarian venous alteration appears to represent a novel addition to the spectrum of cardiovascular injuries associated with carcinoid tumors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/PGP.0000000000000114

  6 / 1925031 MEDLINE  
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[PMID]: 25473750
[Au] Autor:Muller KE; Tafe LJ; Gonzalez JL; West LA; Schned AR
[Ad] Address:Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.
[Ti] Title:Ovarian Strumal Carcinoid Producing Peptide YY Associated With Severe Constipation: A Case Report and Review of the Literature.
[So] Source:Int J Gynecol Pathol;34(1):30-5, 2015 Jan.
[Is] ISSN:1538-7151
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Primary carcinoid tumors are rare neoplasms of the ovary. Of the 4 histologic subtypes, ovarian carcinoid tumors with insular patterns produce carcinoid syndrome in approximately one third of cases, versus strumal and trabecular carcinoids which very rarely cause typical carcinoid syndrome. A unique presentation of ovarian carcinoid tumors with concurrent severe constipation has been reported, which is thought to represent a new carcinoid syndrome. The proposed mechanism is the production of peptide YY by the tumor, a gastrointestinal hormone responsible for decreasing gut motility. We report a case of a 34-yr-old white woman who presented with constipation and weight loss for 1 yr, and was found to have a unilateral ovarian strumal carcinoid, which produced peptide YY as demonstrated by immunohistochemistry. The 13 previous case reports of ovarian carcinoids with constipation are reviewed and the clinicopathologic features are discussed. This report and literature review further solidifies this entity as a new type of carcinoid syndrome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/PGP.0000000000000117

  7 / 1925031 MEDLINE  
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[PMID]: 25473748
[Au] Autor:Desouki MM; Khabele D; Crispens MA; Fadare O
[Ad] Address:Departments of Pathology, Microbiology and Immunology (M.M.D., O.F.) Obstetrics and Gynecology (D.K., M.A.C., O.F.), Division of Gynecologic Oncology, Vanderbilt University Medical Center, Nashville, Tennessee.
[Ti] Title:Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision?
[So] Source:Int J Gynecol Pathol;34(1):19-24, 2015 Jan.
[Is] ISSN:1538-7151
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Ovarian mucinous tumors with mural nodules are rare surface epithelial-stromal tumors. The mural nodules are divergent neoplasms that may be benign or malignant. The latter may be in the form of a sarcoma, carcinosarcoma, anaplastic carcinoma, or a variety of other recognized histotypes of carcinoma, which raises the question of whether malignant mural nodules represent a form of dedifferentiation in ovarian mucinous tumors or whether they represent collision tumors. We recently reported the K-RAS gene mutation status in a case of ovarian mucinous adenocarcinoma with mural nodule of high-grade sarcoma. The mucinous and sarcomatous components revealed a mutation in codon 12 of the K-RAS gene of a different nucleotide substitution, indicating that these 2 tumor components were different clones of the same tumor. Herein, we are reporting another case of a 20-yr-old woman who presented with 22 cm pelvic mass, omental caking, and ascites. A diagnosis of invasive mucinous carcinoma with mural nodules of anaplastic carcinoma was rendered. K-RAS gene mutation studies revealed p.G12V, c.35G>T mutation in the 2 components of the tumor, which is the most common mutation reported in mucinous tumors of the ovary. The fact that sarcomatous or anaplastic carcinomatous mural nodules in ovarian mucinous tumors display the same K-RAS mutations as their underlying mucinous neoplasms provides supportive evidence that at least some malignant mural nodules represent a form of dedifferentiation in ovarian mucinous tumors, rather than a collision of 2 divergent tumor types.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/PGP.0000000000000105

  8 / 1925031 MEDLINE  
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[PMID]: 25467031
[Au] Autor:Antar A; Ishak RS; Otrock ZK; El-Majzoub N; Ghosn S; Mahfouz R; Taher AT
[Ad] Address:Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon....
[Ti] Title:Successful treatment of hydroxyurea-associated chronic leg ulcers associated with squamous cell carcinoma.
[So] Source:Hematol Oncol Stem Cell Ther;7(4):166-9, 2014 Dec.
[Is] ISSN:1658-3876
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Hydroxyurea (HU) is an antineoplastic drug used in the treatment of chronic myeloproliferative neoplasms (MPNs). HU is associated with cutaneous adverse effects, whereas severe complications such as leg ulcers and non-melanoma skin cancers (NMSCs) are rare and only observed after long-term treatment. We herein report a patient with essential thrombocythemia (ET) treated chronically with HU, and who developed refractory bilateral leg ulcers complicated by squamous cell carcinoma (SCC) over both heels. The patient was successfully managed by multiple debridement stages and skin grafting surgeries.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 1925031 MEDLINE  
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[PMID]: 25479752
[Au] Autor:Sánchez-Aguilera A; Arranz L; Martín-Pérez D; García-García A; Stavropoulou V; Kubovcakova L; Isern J; Martín-Salamanca S; Langa X; Skoda RC; Schwaller J; Méndez-Ferrer S
[Ad] Address:Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain. Electronic address: abel.sanchez-aguilera@cnic.es....
[Ti] Title:Estrogen Signaling Selectively Induces Apoptosis of Hematopoietic Progenitors and Myeloid Neoplasms without Harming Steady-State Hematopoiesis.
[So] Source:Cell Stem Cell;15(6):791-804, 2014 Dec 4.
[Is] ISSN:1875-9777
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Estrogens are potent regulators of mature hematopoietic cells; however, their effects on primitive and malignant hematopoietic cells remain unclear. Using genetic and pharmacological approaches, we observed differential expression and function of estrogen receptors (ERs) in hematopoietic stem cell (HSC) and progenitor subsets. ERα activation with the selective ER modulator (SERM) tamoxifen induced apoptosis in short-term HSCs and multipotent progenitors. In contrast, tamoxifen induced proliferation of quiescent long-term HSCs, altered the expression of self-renewal genes, and compromised hematopoietic reconstitution after myelotoxic stress, which was reversible. In mice, tamoxifen treatment blocked development of JAK2(V617F)-induced myeloproliferative neoplasm in vivo, induced apoptosis of human JAK2(V617F+) HSPCs in a xenograft model, and sensitized MLL-AF9(+) leukemias to chemotherapy. Apoptosis was selectively observed in mutant cells, and tamoxifen treatment only had a minor impact on steady-state hematopoiesis in disease-free animals. Together, these results uncover specific regulation of hematopoietic progenitors by estrogens and potential antileukemic properties of SERMs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 1925031 MEDLINE  
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[PMID]: 25179152
[Au] Autor:Mason EJ; Grell JA; West SA; Conover CA
[Ad] Address:Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic, 200 First Street SW, 5-194 Joseph, Rochester, MN55905, USA. Electronic address: Emily.mason.1@vanderbilt.edu....
[Ti] Title:Motor and memory testing of long-lived pregnancy-associated plasma protein-A knock-out mice.
[So] Source:Growth Horm IGF Res;24(6):251-5, 2014 Dec.
[Is] ISSN:1532-2238
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:UNLABELLED: Mice deficient in pregnancy-associated plasma protein-A (PAPP-A), an IGF binding protein protease, have been shown to be resistant to experimentally induced atherosclerosis and diabetic nephropathy, and, in the laboratory environment, live 30-40% longer than wild-type littermates in association with delayed incidence and occurrence of age-related neoplasms and degenerative diseases. OBJECTIVE: PAPP-A is highly expressed in the cerebellum and hippocampus of the mouse brain. Therefore, the studies presented here were aimed at determining motor behavior, learning and retention in PAPP-A knock-out (KO) mice compared to wild-type (WT) littermates with age. DESIGN: Balance and coordination were assessed using an accelerating rotarod; learning and memory were assessed in a Stone T-maze. RESULTS: Time on the rotarod decreased with age but there was no significant difference between PAPP-A KO and WT mice at any of the testing ages. Latency to reach the goal box and number of errors committed in the Stone T-maze did not change with age and there were no significant differences between PAPP-A KO and WT mice. CONCLUSION: Lack of PAPP-A in mice did not impact central regulation of coordination, learning or memory.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Cu] Class update date: 141205
[Lr] Last revision date:141205
[Js] Journal subset:IM
[St] Status:In-Data-Review


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