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[PMID]: 24325556
[Au] Autor:Fernandes AI; Tralhão JG; Abrantes A; Hoti E; Alexandrino H; Oliveiros B; Ferreira M; Botelho MF; Sousa FC
[Ad] Address:Gastroenterology Department, Coimbra University Hospital, Coimbra, Portugal.
[Ti] Title:Functional hepatocellular regeneration in elderly patients undergoing hepatectomy.
[So] Source:Liver Int;35(4):1116-23, 2015 Apr.
[Is] ISSN:1478-3231
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND & AIMS: More than 50% of liver tumours occur in patients aged 65 years or more. Assessment of functional liver regeneration capacity is crucial to minimize postoperative liver failure. We aimed to study functional hepatocellular regeneration, through scintigraphic quantification of Mebrofenin hepatic extraction fraction (HEF), after partial hepatectomy, comparing elderly patients with younger ones. METHODS: One hundred and two patients undergoing partial hepatectomy for primary or secondary hepatic lesions were prospectively included and divided in two groups: Group A - 58 patients aged <65 years (33 men, 53.9 ± 8.7 years), Group B - 44 patients aged ≥65 years (32 men, 71 ± 5 years). Groups were comparable in several aspects except for the presence of cirrhosis (more common in Group B, all patients Child-Pugh score A) and the initial diagnosis (Group B - primary lesions, Group A - metastases). The scintigraphic evaluation of Mebrofenin-HEF was performed before surgery, on the 5th and 30th day post-hepatectomy. RESULTS: Mortality and morbidity were 3.4 and 12.1%, respectively, in Group A and 2.3 and 11.4% in Group B (n.s.). HEF values (%), T1/2 (min) and Tmax (min) showed no significant differences between the two groups: Group A (preoperative: HEF = 99.2 ± 1.5%, T1/2 = 36.7 ± 21.3, Tmax = 15 ± 6. Day 5: HEF = 96.3 ± 10.8%, T1/2 = 76.4 ± 75.9; Tmax = 13.3 ± 4.9. Day 30: HEF = 98.4 ± 5.5%, T1/2 = 38.6 ± 7.7, Tmax = 12.8 ± 3.6) and Group B (preoperative: HEF = 95.3 ± 13%, T1/2 = 38.1 ± 24.1; Tmax = 15.9 ± 9.4. Day 5: HEF = 98.4 ± 2.6%, T1/2 = 106.6 ± 131.7; Tmax = 15.1 ± 6.2. Day 30: HEF = 99 ± 2.1%, T1/2 = 40.5 ± 27; Tmax = 15.5 ± 6.7). CONCLUSION: Our results suggest that functional hepatocellular regeneration is early, fast and similar between elderly and younger patients. Thus, age alone, does not appear to represent an absolute contraindication to hepatectomy.
[Mh] MeSH terms primary: Hepatectomy
Liver Neoplasms/surgery
Liver Regeneration
[Mh] MeSH terms secundary: Adult
Age Factors
Aged
Aged, 80 and over
Female
Hepatectomy/adverse effects
Hepatectomy/mortality
Humans
Imino Acids
Liver Function Tests
Liver Neoplasms/mortality
Liver Neoplasms/physiopathology
Liver Neoplasms/radionuclide imaging
Male
Middle Aged
Organotechnetium Compounds
Patient Selection
Predictive Value of Tests
Prospective Studies
Radiopharmaceuticals
Risk Factors
Time Factors
Treatment Outcome
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Imino Acids); 0 (Organotechnetium Compounds); 0 (Radiopharmaceuticals); F2NQ468L52 (technetium Tc 99m mebrofenin)
[Em] Entry month:1512
[Cu] Class update date: 160612
[Lr] Last revision date:160612
[Js] Journal subset:IM
[Da] Date of entry for processing:150311
[St] Status:MEDLINE
[do] DOI:10.1111/liv.12433

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[PMID]: 25520158
[Au] Autor:Galán M; Farran L; Aliste L; Hormigo G; Aranda H; Bettonica C; Boladeras AM; Botargues JM; Calvo M; Creus G; De Lama ME; Gornals JB; Mast R; Miró M; Paúles MJ; Robles J; Virgili N; Borràs JM
[Ad] Address:Multidisciplinary Oesophagogastric Tumour Committee and Unit, Catalonian Institute of Oncology, IDIBELL, Barcelona, Spain, mnomen@iconcologia.net.
[Ti] Title:Multidisciplinary cancer care may impact on the postoperative mortality and survival of patients with oesophageal and oesophagogastric junction cancer: a retrospective cohort study.
[So] Source:Clin Transl Oncol;17(3):247-56, 2015 Mar.
[Is] ISSN:1699-3055
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:BACKGROUND: Modern management of Oesophageal and oesophagogastric junction (OGJ) cancers requires a multidisciplinary approach, which was implemented at our health centre in 2005. This study aimed to assess the impact of this change on clinical outcomes. METHODS: A retrospective cohort study was conducted, covering all patients treated for oesophageal and OGJ cancer at the cancer centre established by the Bellvitge University Hospital and Catalonian Institute of Oncology, over two time periods, i.e. 2000-2004 and 2005-2008. Descriptive and multivariate analyses were performed using survival at 1 and 3 years as dependent variables. RESULTS: Between 1 January 2000 and 31 December 2008, 586 patients were included. Number of patients with unknown stage at diagnosis was significantly reduced. Preoperative strategies at the oesophageal location clearly increased in the recent period. A multidisciplinary approach resulted in a significant reduction in surgical mortality (11.8 vs. 2 %) in the period 2005-2008. Analysis restricted to patients undergoing surgery with curative intent indicated a significant increase in 1- and 3-year survival in the latter period (68.4 vs. 89.8 and 38.2 vs. 57.1 %, respectively). Multivariate analysis showed that variables associated with improved survival were: age; tumour stage; radical intent of treatment (surgery and radical combined chemoradiotherapy); and therapeutic strategy. CONCLUSION: Better selection of patients for therapy together with improved staging resulted in a significant improvement in 1- and 3-year survival in cases undergoing surgery with curative intent. These changes would support the adoption of a multidisciplinary approach to clinical decision-making in cases of oesophageal and OGJ cancer.
[Mh] MeSH terms primary: Esophageal Neoplasms/mortality
Esophagogastric Junction/pathology
Stomach Neoplasms/mortality
[Mh] MeSH terms secundary: Esophageal Neoplasms/surgery
Female
Humans
Male
Middle Aged
Postoperative Period
Retrospective Studies
Stomach Neoplasms/surgery
Survival Rate
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1605
[Cu] Class update date: 160612
[Lr] Last revision date:160612
[Js] Journal subset:IM
[Da] Date of entry for processing:150212
[St] Status:MEDLINE
[do] DOI:10.1007/s12094-014-1221-7

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[PMID]: 24140312
[Au] Autor:Olivieri C; Nanni L; De Gaetano AM; Manganaro L; Pintus C
[Ad] Address:Pediatric Surgery Unit, Policlinico "A. Gemelli", Rome, Italy. Electronic address: claudioolivieri@libero.it....
[Ti] Title:Complete Resolution of Retroperitoneal Lymphangioma with a Single Trial of OK-432 in an Infant.
[So] Source:Pediatr Neonatol;57(3):240-3, 2016 Jun.
[Is] ISSN:2212-1692
[Cp] Country of publication:Singapore
[La] Language:eng
[Ab] Abstract:Retroperitoneal lymphangioma is extremely rare. Although these neoplasms are benign, they can grow progressively with subsequent compression and infiltration of the adjacent structures. Surgical excision is demanding when the lesion surrounds vital structures and it is generally fraught with a high recurrence and morbidity rate. We report the case of a huge retroperitoneal lymphangioma in a newborn treated successfully with intracystic injection of OK-432.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 2164095 MEDLINE  
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[PMID]: 26518582
[Au] Autor:Lambregts DM; Lahaye MJ; Heijnen LA; Martens MH; Maas M; Beets GL; Beets-Tan RG
[Ad] Address:Department of Radiology, Maastricht University Medical Centre+, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands. doenja.lambregts@gmail.com....
[Ti] Title:MRI and diffusion-weighted MRI to diagnose a local tumour regrowth during long-term follow-up of rectal cancer patients treated with organ preservation after chemoradiotherapy.
[So] Source:Eur Radiol;26(7):2118-25, 2016 Jul.
[Is] ISSN:1432-1084
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To assess the value of MRI and diffusion-weighted imaging (DWI) for diagnosing local tumour regrowth during follow-up of organ preservation treatment after chemoradiotherapy for rectal cancer. METHODS: Seventy-two patients underwent organ preservation treatment (chemoradiotherapy + transanal endoscopic microsurgery or "wait-and-see") and were followed with MRI including DWI (1.5 T) every 3 -months during the first year and 6 months during following years. Two readers scored each MRI for local regrowth using a confidence level, first on standard MRI, then on standard MRI+DWI. Histology and clinical follow-up were the standard reference. Receiver operating characteristic curves were constructed and areas under the curve (AUC) and corresponding accuracy figures calculated on a per-scan basis. RESULTS: Four hundred and forty MRIs were assessed. Twelve patients developed local regrowth. AUC/sensitivity/specificity for standard MRI were 0.95/58 %/98 % (R1) and 0.96/58 % /100 % (R2). For standard MRI+DWI, these numbers were 0.86/75 %/97 % (R1) and 0.98/75 %/100 % (R2). After adding DWI, the number of equivocal scores decreased from 22 to 7 (R1) and from 40 to 20 (R2). CONCLUSIONS: Although there was no overall improvement in diagnostic performance in terms of AUC, adding DWI improved the sensitivity of MRI for diagnosing local tumour regrowth and lowered the rate of equivocal MRIs. KEY POINTS: • DWI improves sensitivity for detecting local tumour regrowth after organ preservation treatment. • In particular, DWI can aid in detecting small local recurrence. • DWI reduces the number of equivocal scores.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00330-015-4062-z

  5 / 2164095 MEDLINE  
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[PMID]: 26449562
[Au] Autor:Attyé A; Karkas A; Troprès I; Roustit M; Kastler A; Bettega G; Lamalle L; Renard F; Righini C; Krainik A
[Ad] Address:Department of Neuroradiology and MRI, Grenoble University Hospital - SFR RMN Neurosciences, Grenoble, France. aattye@chu-grenoble.fr....
[Ti] Title:Parotid gland tumours: MR tractography to assess contact with the facial nerve.
[So] Source:Eur Radiol;26(7):2233-41, 2016 Jul.
[Is] ISSN:1432-1084
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To assess the feasibility of intraparotid facial nerve (VIIn) tractographic reconstructions in estimating the presence of a contact between the VIIn and the tumour, in patients requiring surgical resection of parotid tumours. METHODS: Patients underwent MR scans with VIIn tractography calculated with the constrained spherical deconvolution model. The parameters of the diffusion sequence were: b-value of 1000 s/mm(2); 32 directions; voxel size: 2 mm isotropic; scan time: 9'31'. The potential contacts between VIIn branches and tumours were estimated with different initial fractional anisotropy (iFA) cut-offs compared to surgical data. Surgeons were blinded to the tractography reconstructions and identified both nerves and contact with tumours using nerve stimulation and reference photographs. RESULTS: Twenty-six patients were included in this study and the mean patient age was 55.2 years. Surgical direct assessment of VIIn allowed identifying 0.1 as the iFA threshold with the best sensitivity to detect tumour contact. In all patients with successful VIIn identification by tractography, surgeons confirmed nerve courses as well as lesion location in parotid glands. Mean VIIn branch FA values were significantly lower in cases with tumour contact (t-test; p ≤ 0.01). CONCLUSIONS: This study showed the feasibility of intraparotid VIIn tractography to identify nerve contact with parotid tumours. KEY POINTS: • Diffusion imaging is an efficient method for highlighting the intraparotid VIIn. • Visualization of the VIIn may help to better manage patients before surgery. • We bring new insights to future trials for patients with VIIn dysfunction. • We aimed to provide radio-anatomical references for further studies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00330-015-4049-9

  6 / 2164095 MEDLINE  
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[PMID]: 27157863
[Au] Autor:Santorelli ML; Hirshfield KM; Steinberg MB; Rhoads GG; Lin Y; Demissie K
[Ad] Address:Department of Epidemiology, School of Public Health, Rutgers, The State University of New Jersey, 683 Hoes Lane West, Piscataway. Electronic address: veziname@sph.rutgers.edu....
[Ti] Title:Hormonal therapy for breast cancer and diabetes incidence among postmenopausal women.
[So] Source:Ann Epidemiol;26(6):436-40, 2016 Jun.
[Is] ISSN:1873-2585
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: The purpose of this study was to evaluate associations between hormonal therapy for breast cancer and subsequent diabetes incidence. METHODS: The Surveillance, Epidemiology and End Results-Medicare linked data were used. Stage I-III breast cancer patients 65 years or older who filled at least two prescriptions for an aromatase inhibitor (AI) or tamoxifen by the end of 2008, and within 12 months of breast cancer diagnosis, were selected. Women without cancer from a 5% random sample of Medicare beneficiaries were frequency matched to patients by age group, and new onset diabetes was monitored for 24 months postbaseline in both groups of women. RESULTS: Cox-proportional hazards analysis failed to show an association between AI use and subsequent diabetes onset after adjusting for age, race, and comorbidity (hazard ratio: 0.99; 95% confidence interval: 0.84-1.18). This study also failed to show an association between tamoxifen use and diabetes onset (hazard ratio: 0.79; 95% confidence interval: 0.54-1.17). CONCLUSIONS: Study findings provide evidence that postmenopausal AI and tamoxifen users do not experience an increased risk of diabetes in the 2 years after treatment initiation. Whether these findings will hold with longer duration follow-up deserves a closer look.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 27274897
[Au] Autor:Akay E; Kala M; Karaman H
[Ad] Address:Clinic of Pathology, Kayseri Education and Training Hospital, Kayseri, Turkey.
[Ti] Title:Gastric metastasis of renal cell carcinoma 20 years after radical nephrectomy.
[So] Source:Turk J Urol;42(2):104-7, 2016 Jun.
[Is] ISSN:2149-3235
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:Renal cell carcinomas account for 2-3% of malignant neoplasms in adults. The lung, soft tissues and bone represent the most frequent sites of distant metastasis in renal cell carcinoma. Gastric metastasis is rare. Our case was a 72-year-old man with complaints of fatigue and loss of appetite. In history, he had unergone radical nephrectomy due to renal cell carcinoma in 1993. A polypoid lesion was observed in upper gastrointestinal endoscopy. Histopathology of gastric biopsy specimen was reported as renal cell carcinoma. In English literature, there are 50 cases diagnosed as gastric metastasis from renal cell carcinoma. To date, there are only 4 cases with extremely late gastric metastasis of renal cell carcinoma. Herein, we present a rare case which underwent radical nephrectomy due to renal cell carcinoma and found to have gastric metastasis at 20. year of his follow-up.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 160610
[Lr] Last revision date:160610
[Da] Date of entry for processing:160609
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5152/tud.2016.34022

  8 / 2164095 MEDLINE  
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[PMID]: 27275284
[Au] Autor:El Din AA; Badawi MA; Aal SE; Ibrahim NA; Morsy FA; Shaffie NM
[Ad] Address:Pathology Department, National Research Centre, Cairo, Egypt....
[Ti] Title:DNA Cytometry and Nuclear Morphometry in Ovarian Benign, Borderline and Malignant Tumors.
[So] Source:Open Access Maced J Med Sci;3(4):537-44, 2015 Dec 15.
[Is] ISSN:1857-9655
[Cp] Country of publication:Macedonia
[La] Language:eng
[Ab] Abstract:BACKDROUND: Ovarian carcinoma is a leading cause of death in gynecological malignancy. Ovarian surface epithelial serous and mucinous tumours are classified as benign, borderline, and malignant. The identification of borderline tumours most likely to act aggressively remains an important clinical issue. AIM: This work aimed to study DNA ploidy and nuclear area in ovarian serous and mucinous; benign, borderline and malignant tumours. MATERIAL AND METHODS: This study included forty ovarian (23 serous and 17 mucinous) tumours. Paraffin blocks were sectioned; stained with haematoxylin and eosin for histopathologic and morphometric studies and with blue feulgen for DNA analysis. RESULTS: All four serous and six out of nine mucinous benign tumours were diploid. All eight serous and five mucinous malignant tumours were aneuploid. Nine of eleven (81.8%) serous and all three mucinous borderline tumours were aneuploid. There were highly significant differences in mean aneuploid cells percentage between serous benign (1.5%), borderline (45.6%) and malignant (74.5%) (p = 0.0001) and between mucinous benign (13.2%) and both borderline (63.7%) and malignant (68.4%) groups (p = 0.0001). There were significant differences in nuclear area between serous benign (26.191%), borderline (45.619%) and malignant (67.634 %) and a significant positive correlation between mean percentage aneuploid value and mean nuclear area in all serous and mucinous groups. CONCLUSION: We suggest that DNA ploidy and nuclear area combined, may be adjuncts to histopathology; in ovarian serous and mucinous benign, borderline and malignant neoplasms; identifying the aggressive borderline tumours.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 160610
[Lr] Last revision date:160610
[Da] Date of entry for processing:160609
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3889/oamjms.2015.104

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[PMID]: 27275246
[Au] Autor:Shakib MC; Gabrial SG; Gabrial GN
[Ad] Address:National Research Centre, Nutrition and Food Science Department, El Buhouth St., Dokki, Cairo 12311, Egypt.
[Ti] Title:Beetroot-Carrot Juice Intake either Alone or in Combination with Antileukemic Drug 'Chlorambucil' As A Potential Treatment for Chronic Lymphocytic Leukemia.
[So] Source:Open Access Maced J Med Sci;3(2):331-6, 2015 Jun 15.
[Is] ISSN:1857-9655
[Cp] Country of publication:Macedonia
[La] Language:eng
[Ab] Abstract:Chronic lymphocytic leukemia (CLL) is one of the chronic lymphoproliferative disorders (lymphoid neoplasms). It is characterized by a progressive accumulation of functionally incompetent lymphocytes. Patients with leukemia often seek unconventional treatments not prescribed by hematologist in order to improve their cancer treatment outcome or to manage symptoms. In the present report, a 76-year-old patient was diagnosed with B-cell chronic lymphocytic leukemia (B-CLL). Beetroot-carrot juice is used as a complementary and or/alternative therapy used in conjunction with conventional leukemic treatment (chlorambucil) that has been a standard first-line chemotherapeutic agent for patients with CLL and known to have serious and undesirable side-effects. After one month and 15 days of administration of beetroot-carrot juice therapy, the patient had improved appetite, a sense of general well-being and increased vigor daily activities. Furthermore, beetroot-carrot juice was used as an adjuvant to chlorambucil resulted in a substantial reduction in leukocytes and lymphocytes count in peripheral blood and improvement in the relevant biochemical parameters. Beetroot-carrot juice can be used as an effective treatment for CLL alone or in combination with chlorambucil when taken orally with regular diet on daily basis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 160610
[Lr] Last revision date:160610
[Da] Date of entry for processing:160609
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3889/oamjms.2015.056

  10 / 2164095 MEDLINE  
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[PMID]: 27275364
[Au] Autor:Jeong JH; Cho IH; Chun KA; Kong EJ; Kwon SD; Kim JH
[Ad] Address:Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea....
[Ti] Title:Correlation Between Apparent Diffusion Coefficients and Standardized Uptake Values in Hybrid (18)F-FDG PET/MR: Preliminary Results in Rectal Cancer.
[So] Source:Nucl Med Mol Imaging;50(2):150-6, 2016 Jun.
[Is] ISSN:1869-3474
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: Fluorine-18-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI) share the same role in clinical oncology and it is feasible to obtain the standardized uptake value (SUV) and apparent diffusion coefficient (ADC) simultaneously by emerging the hybrid positron emission tomography/magnetic resonance (PET/MR). This study investigated the correlation between the ADCs of rectal cancer lesions and their SUVs derived from hybrid PET/MR. METHODS: Nine patients with histologically proven rectal adenocarcinoma (5 men, 4 women; mean age, 70 ± 15.91 years) underwent torso (18)F-FDG PET/CT and regional hybrid (18)F-FDG PET/MR sequentially. A fixed threshold value of 40 % of maximum uptake was used to determine tumor volume of interest (VOI) on PET image; SUVmax, SUVpeak, and SUVmean were calculated automatically. A single freehand region of interest (ROI) was drawn on high b-value (b1000) DWI image and copied to corresponding ADC map to determine the ADCmean of rectal cancer lesion. Spearman's rank correlation coefficient (ρ) was calculated to determine the correlation between SUVs and ADC values. RESULTS: SUVmax, SUVpeak, and SUVmean derived by hybrid PET/MR were 12.35 ± 4.66 (mean ± standard deviation), 9.66 ± 3.15 and 7.41 ± 2.54, respectively. The ADCmean value of rectal cancer lesions was 1.02 ± 0.08 × 10(-3)mm(2)/s. ADCmean was significantly and inversely correlated with SUV values (SUVmax, ρ = -0.95, p < 0.001; SUVpeak, ρ = -0.93, p < 0.001; SUVmean, ρ = -0.91, p = 0.001). CONCLUSIONS: This preliminary hybrid PET/MR study demonstrates a significant inverse correlation exists between metabolic activity on (18)F-FDG PET and water diffusion on DWI in rectal cancer.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 160610
[Lr] Last revision date:160610
[Da] Date of entry for processing:160609
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1007/s13139-015-0390-9


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