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[PMID]: 25374945
[Au] Autor:Negri G; Bandiera A; Ciriaco P; Melloni G; Carretta A; Cremona GI; Zannini P
[Ad] Address:Department of Thoracic Surgery, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy....
[Ti] Title:Solitary fibrous tumour of the pleura presenting as a spontaneous massive haemothorax.
[So] Source:Surg Res Pract;2014:139404, 2014.
[Is] ISSN:2356-7759
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Solitary fibrous tumours of the pleura are rare neoplasms. These tumours are generally asymptomatic and incidentally diagnosed. Symptoms, if present, are nonspecific such as cough, dyspnea, and chest pain. This report describes the case of a 38-year-old woman admitted to our department after the onset of a right massive spontaneous haemothorax requiring emergency surgical treatment. Intraoperatively a bleeding pleural mass was found to be the cause of the haemothorax. The tumour was successfully resected and the patient made an uneventful recovery. Histological examination revealed the mass to be a solitary fibrous tumour of the pleura.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Da] Date of entry for processing:141106
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2014/139404

  2 / 1921471 MEDLINE  
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SciELO Brazil full text
SciELO Public Health full text

[PMID]: 25372172
[Au] Autor:Coelho TL; Ferré F; Campos Neto OH; Acurcio Fde A; Cherchiglia ML; Andrade EI
[Ti] Title:Legal and health variations in drug litigation injunctions granted in Minas Gerais.
[So] Source:Rev Saude Publica;48(5):808-16, 2014 Oct.
[Is] ISSN:1518-8787
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:OBJECTIVE To investigate the factors related to the granting of preliminary court orders [injunctions] in drug litigations. METHODS A retrospective descriptive study of drug lawsuits in the State of Minas Gerais, Southeastern Brazil, was conducted from October 1999 to 2009. The database consists of 6,112 lawsuits, out of which 6,044 had motions for injunctions and 5,167 included the requisition of drugs. Those with more than one beneficiary were excluded, which totaled 5,072 examined suits. The variables for complete, partial, and suppressed motions were treated as dependent and assessed in relation to those that were independent - lawsuits (year, type, legal representation, defendant, court in which it was filed, adjudication time), drugs (level five of the anatomical therapeutic chemical classification), and diseases (chapter of the International Classification of Diseases). Statistical analyses were performed using the Chi-square test. RESULTS Out of the 5,072 lawsuits with injunctions, 4,184 (82.5%) had the injunctions granted. Granting varied from 95.8% of the total lawsuits in 2004 to 76.9% in 2008. Where there was legal representation, granting exceeded 80.0% and in lawsuits without representation, it did not exceed 66.9%. In public civil actions (89.1%), granting was higher relative to ordinary lawsuits (82.8%) and injunctions (80.1%). Federal courts granted only 68.6% of the injunctions, while the state courts granted 84.8%. Diseases of the digestive system and neoplasms received up to 87.0% in granting, while diseases of the nervous system, mental and behavioral disorders, and diseases of the skin and subcutaneous tissue received granting below 78.6% and showed a high proportion of suspended injunctions (10.9%). Injunctions involving paroxetine, somatropin, and ferrous sulfate drugs were all granted, while less than 54.0% of those involving escitalopram, sodium diclofenac, and nortriptyline were granted. CONCLUSIONS There are significant differences in the granting of injunctions, depending on the procedural and clinical variances. Important trends in the pattern of judicial action were observed, particularly, in the reduced granting [of injunctions] over the period.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 1921471 MEDLINE  
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[PMID]: 25372318
[Au] Autor:Hazan A; Katz MS; Leder H; Blace N; Szlechter M
[Ad] Address:*Albert Einstein College of Medicine; †Department of Ophthalmology, Montefiore Medical Center, Bronx, New York; and ‡Department of Ophthalmology, Jacobi Medical Center.
[Ti] Title:Choroidal metastases of choriocarcinoma.
[So] Source:Retin Cases Brief Rep;8(2):95-6, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: We present here a patient with choroidal metastases of choriocarcinoma; her clinical and pathologic findings are described. METHODS: Retrospective case study with fundus photographs. A 23-year-old woman presented with a dense vitritis, retinal detachment, and underlying chorioretinal lesions. Systemic workup revealed choriocarcinoma with disseminated metastases. RESULTS: This patient's underlying malignancy was unrecognized at initial presentation to ophthalmology. This case reaffirms the importance of thorough systemic investigation for atypical intraocular lesions. CONCLUSION: Adult intraocular neoplasms are most commonly metastases from distal primary malignancies. The same holds true for uveal malignancies. In many uveal malignancies, the intraocular lesion is a harbinger for an, as yet, undiscovered underlying systemic malignancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0000000000000012

  4 / 1921471 MEDLINE  
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[PMID]: 25372415
[Au] Autor:Liszka L; Mrowiec S; Pajak J; Kostrzab-Zdebel A; Lampe P; Kajor M
[Ad] Address:Lukasz Liszka MD, Department of Pathomorphology in Katowice, Medical University of Silesia, Medyków 18, 40-754 Katowice, Poland, tel./fax +48 32 25 25 080, e-mail: lliszka@mp.pl.
[Ti] Title:Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas.
[So] Source:Pol J Pathol;65(3):182-93, 2014 Nov.
[Is] ISSN:1233-9687
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Solid-pseudopapillary neoplasms (SPN) are rare tumours of the pancreas. Distant metastases and/or local recurrence following surgical resection occur in 10% to 15% of patients with SPN. In the present study, we aimed to systematically examine the usefulness of virtually all histopathological features of SPN which were previously considered potential risk factors of clinically aggressive behaviour of SPN following surgical resection. Seventeen SPN were included. None of the cases had an undifferentiated component. Follow-up data were available for 14 patients (median 52 months). One patient developed liver metastasis 17 months after resection of the primary tumour and fulfilled the criteria of a clinically aggressive disease. None of the histopathological features allowed identification of that case with an adequate diagnostic yield. At present, histopathological examination cannot identify patients who may develop tumour recurrence following resection of the primary lesion. A close follow-up should be offered to all patients treated for SPN.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 1921471 MEDLINE  
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[PMID]: 25373373
[Au] Autor:Kimura Y; Matsumoto H; Oosawa M; Fujita M; Tarumi K; Kamada T; Shiotani A; Haruma K
[Ad] Address:Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School.
[Ti] Title:Relationship between visceral fat and development of colorectal neoplasms using computed tomographic colonography and adipocytokine levels.
[So] Source:Nihon Shokakibyo Gakkai Zasshi;111(11):2121-30, 2014 Nov.
[Is] ISSN:0446-6586
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:We evaluated the relationship between colorectal neoplasms and visceral obesity using computed tomographic colonography and adipocytokine levels. We included 123 patients and classified them into four groups as per computed tomographic colonography: no lesion (NL; n=40), adenomatous polyp (polyp; n=41), early colorectal cancer (eCRC; n=21), and advanced CRC (aCRC; n=21). We also measured the patients' serum metabolic markers and adipocytokine levels. The visceral adiposity index in the polyp and eCRC groups was significantly higher than that in the NL group. Visceral obesity is an important risk factor for the development of colonic polyps. Computed tomographic colonography could be a useful examination technique not only for diagnosis of colorectal neoplasms but also for simultaneous evaluation of visceral obesity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 1921471 MEDLINE  
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[PMID]: 25374730
[Au] Autor:Caballero T; Caba-Molina M; Salmerón J; Gómez-Morales M
[Ad] Address:Pathology Department, San Cecilio University Hospital and School of Medicine, University of Granada, Avenida de Madrid 11, 18012 Granada, Spain ; Networked Biomedical Research Center for Hepatic and Digestive Diseases (CIBERehd), Carlos III Institute of Health, Spain....
[Ti] Title:Nonalcoholic steatohepatitis in a patient with ataxia-telangiectasia.
[So] Source:Case Reports Hepatol;2014:761250, 2014.
[Is] ISSN:2090-6587
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Ataxia-telangiectasia (A-T) is a rare disease characterized by neurodegenerative alterations, telangiectasia, primary immunodeficiency, extreme sensitivity to radiation, and susceptibility to neoplasms. A-T patients have inactivation of ataxia-telangiectasia-mutated (ATM) protein, which controls DNA double-strand break repair and is involved in oxidative stress response, among other functions; dysfunctional control of reactive oxygen species may be responsible for many of the clinical manifestations of this disease. To the best of our knowledge, hepatic lesions of steatohepatitis have not previously been reported in A-T patients. The present study reports the case of a 22-year-old man diagnosed with A-T at the age of 6 years who was referred to our Digestive Disease Unit with a three-year history of hyperlipidemia and liver test alterations. Core liver biopsy showed similar lesions to those observed in nonalcoholic steatohepatitis. Immunohistochemical staining disclosed the absence of ATM protein in hepatocyte nuclei. We suggest that the liver injury may be mainly attributable to the oxidative stress associated with ATM protein deficiency, although other factors may have made a contribution. We propose the inclusion of A-T among the causes of nonalcoholic steatohepatitis, which may respond to antioxidant therapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Da] Date of entry for processing:141106
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2014/761250

  7 / 1921471 MEDLINE  
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[PMID]: 25307456
[Au] Autor:Kreher S; Ochsenreither S; Trappe RU; Pabinger I; Bergmann F; Petrides PE; Koschmieder S; Matzdorff A; Tiede A; Griesshammer M; Riess H
[Ad] Address:Department of Hematology and Oncology, Charite Berlin, Berlin, Hindenburgdamm 30, 12200, Berlin, Germany, stephan.kreher@charite.de.
[Ti] Title:Prophylaxis and management of venous thromboembolism in patients with myeloproliferative neoplasms: consensus statement of the Haemostasis Working Party of the German Society of Hematology and Oncology (DGHO), the Austrian Society of Hematology and Oncology (ÖGHO) and Society of Thrombosis and Haemostasis Research (GTH e.V.).
[So] Source:Ann Hematol;93(12):1953-63, 2014 Dec.
[Is] ISSN:1432-0584
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) like polycythemia vera and essential thrombocythemia are at increased risk of arterial and venous thrombosis. Strategies of prevention may consist of platelet aggregation inhibitors and/or cytoreductive agents depending on the underlying disease and the individual risk. Clinical evidence for management of acute venous thromboembolic events in MPN patients is limited. Modality and duration of therapeutic anticoagulation after venous thrombosis has to be evaluated critically with special regard to the increased risk for spontaneous bleeding events associated with the underlying diseases. Both for therapy of the acute event and for secondary prophylaxis, low-molecular-weight heparins should preferentially be used. A prolongation of the therapeutic anticoagulation beyond the usual 3 to 6 months can only be recommended in high-risk settings and after careful evaluation of potential risks and benefits for the individual patient. New direct oral anticoagulants (NOAC) should not preferentially be used due to lack of clinical experience in patients with MPN and potential drug interactions (e.g. with JAK inhibitors). Consequent treatment of the underlying myeloproliferative disease and periodical evaluation of the response to therapy is crucial for optimal secondary prophylaxis of thromboembolic events in those patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00277-014-2224-8

  8 / 1921471 MEDLINE  
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[PMID]: 24985089
[Au] Autor:Andrade-Campos MM; Montes-Limón AE; Soro-Alcubierre G; Grasa JM; Lopez-Gómez L; Baringo T; Giraldo P
[Ad] Address:Department of Haematology, Miguel Servet University Hospital, Zaragoza, Spain.
[Ti] Title:Long-term efficacy of (90)Y ibritumomab tiuxetan therapy in follicular non-Hodgkin lymphoma and health-related quality of life.
[So] Source:Ann Hematol;93(12):1985-92, 2014 Dec.
[Is] ISSN:1432-0584
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The aim of this study was to analyze the outcomes of 37 follicular lymphoma (FL) patients treated with (90)ytrium ibritumomab tiuxetan (90Y-IT), outside of clinical trial, according to protocol ISCRTN36210045, after ≥5 years follow-up to February 2014. Health-related quality of life (HRQoL) was evaluated with the SF-36, Spanish version, and compared with the general population of Spain. Patients had a mean age of 61.9 (range, 30-85) years and included 18 males. FLIPI, low: 25 (67.6 %), intermedium 9 (24.3 %), and low 3 (8.1 %). Previous therapy schedules >2: 48.6 % The median follow-up was 66 months, mean Time to Relapse (TTR) 71.3 months (58.8-83.8) median not reached. Thirty-four patients achieved complete response (91.8 %), and three no response. Mean overall survival: 82.3 months (71.6-92.9). Four patients presented with concomitant tumors (colon, breast, prostate, lung) after radioimmunotherapy, and three developed second primary neoplasms (esophagus, renal, and myelodysplastic syndrome in a relapsed patient who received fludarabine). Four of 10 deaths were related to lymphoma progression. Hematological toxicities were mild and easily managed. No patients required hospitalization. Negative scores were obtained in the physical and emotional roles items; however, the perception of general health and vitality were better than in the general population, with the best outcomes in non-relapsed patients. Radioimmunotherapy with 90Y-IT was safe and effective as long-term therapy in patients with FL. Early use of radioimmunotherapy could offer good, sustained responses with low toxicity over the long term and acceptable HRQoL.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00277-014-2145-6

  9 / 1921471 MEDLINE  
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[PMID]: 25374908
[Au] Autor:Ronny FM; Sarungbam J; Zhong X; Yusuf Y; Yang X; Zhong M
[Ad] Address:Department of Pathology, New York Medical College, Westchester Medical Center Valhalla, NY, USA....
[Ti] Title:Glomerular sparing pattern in primary kidney neoplasms: clinical, morphological and immunohistochemical study.
[So] Source:Am J Clin Exp Urol;2(1):76-81, 2014.
[Is] ISSN:2330-1910
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Glomerular sparing (GS) is defined as a unique growth pattern in which tumor cells replace the majority of renal tubes and overrun intact glomeruli. This phenomenon has been well recognized by pathologists as a typical infiltrative pattern and some studies suggested it was an independent risk factor. Here, we study the clinical, pathological, and immunohistochemical features of primary kidney neoplasms with glomerular sparing pattern. We searched the archives of our pathology department for nephrectomy specimens and reviewed all pathology reports from 2009-2013. We selected cases with tumor and collected clinicopathological information, focusing on re-evaluation of cases with glomerular sparing pattern. To facilitate our study we performed immunohistochemical stains of PAX-8, p63, and InI-1 on selected cases. We selected a total of 204 nephrectomy cases in this study, including 163 cases of renal cell carcinoma; 37 cases of urothelial carcinoma; 4 cases from other categories (Wilms tumor, primary diffuse large B-cell lymphoma, angiolipoma, rhabdoid tumor). Finally, we identified 7 cases of primary kidney tumors with glomerular sparing pattern: 2 cases of clear cell renal cell carcinomas (ccRCC), 1 case of collecting duct carcinoma, 2 cases of urothelial carcinoma (UC), 1 case of diffuse large B-cell lymphoma and 1 case of malignant rhabdoid tumor. The primary kidney tumors with glomerular sparing pattern are rare and incidence in our study is <4% (7/204). There is no specificity for any tumor type, but more commonly seen in high grade UC rather than RCC. It can also be seen in rare neoplasms such as collecting duct carcinoma, lymphoma and malignant rhabdoid tumor. These GS cases need to be recognized as they are often associated with high grade, high stage, large tumor size, and worse prognosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Da] Date of entry for processing:141106
[St] Status:PubMed-not-MEDLINE

  10 / 1921471 MEDLINE  
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[PMID]: 25374985
[Ti] Title:Proceedings of the North American Society of Head and Neck Pathology Companion Meeting, March 2, 2014, San Diego, California.
[So] Source:Head Neck Pathol;8(1):1-131, 2014 Mar.
[Is] ISSN:1936-0568
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Head and Neck Neoplasms
Medical Oncology
[Mh] MeSH terms secundary: Animals
Humans
[Pt] Publication type:CONGRESSES; OVERALL
[Em] Entry month:1411
[Js] Journal subset:IM
[Da] Date of entry for processing:141105
[St] Status:MEDLINE


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