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[PMID]: 28467571
[Au] Autor:Akpinar ÇK; Erdogan S; Cengiz N
[Ad] Address:Department of Neurology, Vezirköprü State Hospital, Samsun, Turkey. dr_ckakpinar@hotmail.com.
[Ti] Title:Lakozamid'e bagli gelisen bas agrisinda büyük oksipital sinir blokajina yanit. [Response of greater occipital nerve block in headache induced by lacosamide].
[So] Source:Agri;29(1):49-50, 2017 01.
[Is] ISSN:1300-0012
[Cp] Country of publication:Turkey
[La] Language:tur
[Pt] Publication type:LETTER; COMMENT
[Em] Entry month:1705
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process
[do] DOI:10.5505/agri.2015.57805

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[PMID]: 29444082
[Au] Autor:Khan MI; Su YK; Zou J; Yang LW; Chou RH; Yu C
[Ad] Address:National Tsing Hua University, Chemistry Department, Hsinchu, Taiwan.
[Ti] Title:S100B as an antagonist to block the interaction between S100A1 and the RAGE V domain.
[So] Source:PLoS One;13(2):e0190545, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Ca2+-binding human S100A1 protein is a type of S100 protein. S100A1 is a significant mediator during inflammation when Ca2+ binds to its EF-hand motifs. Receptors for advanced glycation end products (RAGE) correspond to 5 domains: the cytoplasmic, transmembrane, C2, C1, and V domains. The V domain of RAGE is one of the most important target proteins for S100A1. It binds to the hydrophobic surface and triggers signaling transduction cascades that induce cell growth, cell proliferation, and tumorigenesis. We used nuclear magnetic resonance (NMR) spectroscopy to characterize the interaction between S100A1 and the RAGE V domain. We found that S100B could interact with S100A1 via NMR 1H-15N HSQC titrations. We used the HADDOCK program to generate the following two binary complexes based on the NMR titration results: S100A1-RAGE V domain and S100A1-S100B. After overlapping these two complex structures, we found that S100B plays a crucial role in blocking the interaction site between RAGE V domain and S100A1. A cell proliferation assay WST-1 also supported our results. This report could potentially be useful for new protein development for cancer treatment.
[Mh] MeSH terms primary: Antigens, Neoplasm/metabolism
Mitogen-Activated Protein Kinases/metabolism
S100 Calcium Binding Protein beta Subunit/physiology
S100 Proteins/metabolism
[Mh] MeSH terms secundary: Calcium/metabolism
Humans
Hydrophobic and Hydrophilic Interactions
Nuclear Magnetic Resonance, Biomolecular
Protein Binding
Signal Transduction
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antigens, Neoplasm); 0 (S100 Calcium Binding Protein beta Subunit); 0 (S100 Proteins); 0 (S100A1 protein); 0 (S100B protein, human); EC 2.7.11.22 (MOK protein, human); EC 2.7.11.24 (Mitogen-Activated Protein Kinases); SY7Q814VUP (Calcium)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190545

  3 / 39754 MEDLINE  
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[PMID]: 29520522
[Au] Autor:Zorrilla-Vaca A; Li J
[Ad] Address:Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Phipps 455, Baltimore, MD, USA. andres.zorrilla@correounivalle.edu.co.
[Ti] Title:The role of sciatic nerve block to complement femoral nerve block in total knee arthroplasty: a meta-analysis of randomized controlled trials.
[So] Source:J Anesth;, 2018 Mar 08.
[Is] ISSN:1438-8359
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Femoral nerve block (FNB) appears to have higher postoperative analgesic benefits compared with the patient-controlled analgesia (PCA) in total knee arthroplasty (TKA). However, the role of sciatic nerve block (SNB) as a complement to FNB remains controversial. We performed a meta-analysis assessing the benefits of the SNB as a complement to FNB, as well as comparing the efficacy of single-injection versus continuous SNB in TKA. METHODS: Our group conducted a systematic literature search in PubMed, EMBASE and Google Scholar. We retrieved randomized trials comparing either SNB versus placebo or continuous versus single-injection SNB. The intervention group was the use of SNB as a complement to FNB, while the control group was FNB alone. Pain score at rest and movement (at 4, 12, 24, 48 and 72 h), patient-controlled intravenous opioid consumption, length of hospital stay, and incidence of nausea were extracted from each study. Random-effects model was used for meta-analysis and standardized mean difference (SMD) was used as the effect size. RESULTS: Ten articles comprising 514 patients were included to compare the effects of SNB combined with FNB versus FNB alone. Interventional group was found to significantly reduce pain score at for 4 h (SMD = - 0.94, 95% CI - 1.42 to - 0.47, P < 0.001, I = 76.5%) compared with the control group. Pain score at rest was significantly reduced at movement for 12 h (SMD = - 0.29, 95% CI - 0.54 to - 0.04, P = 0.02, I = 0%). Opioid consumption was significantly reduced at 24 (SMD = - 0.60, 95% CI - 1.01 to - 0.17, P = 0.01, I = 69.1%) and 48 h (SMD = - 1.04, 95% CI - 1.46 to - 0.61, P < 0.001, I = 43.4%) after TKA using SNB as a complement to FNB. Three articles were additionally meta-analyzed to compare the efficacy of single-injection (n = 79) versus continuous SNB (n = 79), being the latter one significantly associated with less pain score at 24 (SMD = -0.77, 95% CI - 1.10 to - 0.45, P < 0.001, I = 0%) and 48 h (SMD = - 0.69, 95% CI - 1.01 to - 0.36, P < 0.001, I = 0%), but not at 12 h (SMD = - 0.34, 95% CI - 0.73 to - 0.06, P = 0.10, I = 0%). CONCLUSIONS: This meta-analysis provides evidence-based supports to the benefits of SNB as a complement to FNB in TKA. The combination sciatic-femoral nerve block appears to be the optimal choice for patients in high risk of postoperative opioids consumption or acute pain after TKA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1007/s00540-018-2480-1

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[PMID]: 29518270
[Au] Autor:Hu B; Mccollum M; Ravi V; Arpag S; Moiseev D; Castoro R; Mobley BC; Burnette BW; Siskind C; Day JW; Yawn R; Feely S; Li Y; Yan Q; Shy ME; Li J
[Ad] Address:Department of Neurology, Center for Human Genetic Research, and Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee.
[Ti] Title:Myelin Abnormality in CMT4J Recapitulates Features of Acquired Demyelination.
[So] Source:Ann Neurol;, 2018 Mar 08.
[Is] ISSN:1531-8249
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Charcot-Marie-Tooth type 4J (CMT4J) is a rare autosomal recessive neuropathy caused by mutations in FIG4 that result in loss of FIG4 protein. This study investigates the natural history and mechanisms of segmental demyelination in CMT4J. METHODS: Over the past 9 years, we have enrolled and studied a cohort of 12 CMT4J patients, including 6 novel FIG4 mutations. We evaluated these patients and related mouse models using morphological, electrophysiological and biochemical approaches. RESULTS: We found sensory motor demyelinating polyneuropathy consistently in all patients. This underlying myelin pathology was associated with non-uniform slowing of conduction velocities, conduction block, and temporal dispersion on nerve conduction studies (NCS), which resemble those features in acquired demyelinating peripheral nerve diseases. Segmental demyelination was also confirmed in mice without Fig4 (Fig4 ). The demyelination was associated with an increase of Schwann cell dedifferentiation and macrophages in spinal roots where nerve blood barriers are weak. Schwann cell dedifferentiation was induced by the increasing intracellular Ca . Suppression of Ca level by a chelator reduced dedifferentiation and demyelination of Schwann cells in vitro and in vivo. Interestingly, cell-specific knockout of Fig4 in mouse Schwann cells or neurons failed to cause segmental demyelination. INTERPRETATION: Myelin change in CMT4J recapitulates the features of acquired demyelinating neuropathies. This pathology is not Schwann cell autonomous. Instead, it relates to systemic processes involving interactions of multiple cell types and abnormally elevated intracellular Ca . Injection of a Ca chelator in Fig4 mice improved segmental demyelination, thereby providing a therapeutic strategy against demyelination. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1002/ana.25198

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[PMID]: 29431744
[Au] Autor:He X; Zhang L; Queme LF; Liu X; Lu A; Waclaw RR; Dong X; Zhou W; Kidd G; Yoon SO; Buonanno A; Rubin JB; Xin M; Nave KA; Trapp BD; Jankowski MP; Lu QR
[Ad] Address:Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
[Ti] Title:A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration.
[So] Source:Nat Med;24(3):338-351, 2018 Mar.
[Is] ISSN:1546-170X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Deficits in Schwann cell-mediated remyelination impair functional restoration after nerve damage, contributing to peripheral neuropathies. The mechanisms mediating block of remyelination remain elusive. Here, through small-molecule screening focusing on epigenetic modulators, we identified histone deacetylase 3 (HDAC3; a histone-modifying enzyme) as a potent inhibitor of peripheral myelinogenesis. Inhibition of HDAC3 enhanced myelin growth and regeneration and improved functional recovery after peripheral nerve injury in mice. HDAC3 antagonizes the myelinogenic neuregulin-PI3K-AKT signaling axis. Moreover, genome-wide profiling analyses revealed that HDAC3 represses promyelinating programs through epigenetic silencing while coordinating with p300 histone acetyltransferase to activate myelination-inhibitory programs that include the HIPPO signaling effector TEAD4 to inhibit myelin growth. Schwann cell-specific deletion of either Hdac3 or Tead4 in mice resulted in an elevation of myelin thickness in sciatic nerves. Thus, our findings identify the HDAC3-TEAD4 network as a dual-function switch of cell-intrinsic inhibitory machinery that counters myelinogenic signals and maintains peripheral myelin homeostasis, highlighting the therapeutic potential of transient HDAC3 inhibition for improving peripheral myelin repair.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1038/nm.4483

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[PMID]: 29392356
[Au] Autor:Ibrahim M; Elnabtity AM; Keera A
[Ad] Address:Department of Anesthesiology, Faculty of Medicine, Zagazig University, Sharkia, Egypt. mibrahim72@hotmail.com.
[Ti] Title:Wirksamkeit einer externen Nasenblockade nach Nasenoperation : Eine randomisierte, kontrollierte Studie. Efficacy of external nasal nerve block following nasal surgery : A randomized, controlled trial.
[So] Source:Anaesthesist;67(3):188-197, 2018 Mar.
[Is] ISSN:1432-055X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: Pain is the major determinant factor which affects the quality of recovery and postoperative agitation following nasal surgery with the patient under general anesthesia. Our objectives were to test the hypothesis that an external nasal nerve block will decrease pain intensity, decrease drug consumption, decrease the incidence of postoperative emergence agitation and improve quality of recovery. MATERIAL AND METHODS: In this study 100 adult patients who were scheduled for elective external nasal surgery with the patient under general anesthesia and nasal packing on each side, received external nasal nerve blocks postoperatively for 24 h with saline (group I) or 2% xylocaine (group II) with 1:200,000 epinephrine. Postoperative pain was measured at the postanesthesia care unit (PACU) utilizing a visual analog scale (VAS). Narcotics consumption was also measured. Emergence agitation and quality of recovery were also assessed. RESULTS: Pain scores were statistically significant between both groups. Requirements of equivalent morphine doses in the PACU were lower in group II (block) than group I (control) with a significant P value <0.001. Group II (block) patients required significantly less intraoperative fentanyl than group I (control) patients (p = 0.001). Group II (block) showed higher scores in pain dimension of QoR-40 in comparison with group I (P <0.001). The incidence of emergence agitation was lower in group II (block) than in group I (control, 24% vs. 48%, P = 0.012). CONCLUSION: External nasal nerve block is an effective technique for reducing postoperative pain, drug consumption and quality of recovery. It also reduces emergence agitation. The effects are mainly due to profound analgesia and effective pain control that lead to decreased drug usage and reduced discomfort.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1007/s00101-018-0410-0

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[PMID]: 29381630
[Au] Autor:Zdilla MJ; Koons AW; Russell ML; Mangus KR; Bliss KN
[Ad] Address:Department of Natural Sciences and Mathematics.
[Ti] Title:The Infraorbital Foramen Is Located Midway Between the Nasospinale and Jugale: Considerations for Infraorbital Nerve Block and Maxillofacial Surgery.
[So] Source:J Craniofac Surg;29(2):523-527, 2018 Mar.
[Is] ISSN:1536-3732
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Identification of the infraorbital foramen is important in infraorbital nerve block and the prevention of iatrogenic injury of the infraorbital nerve in maxillofacial surgeries. This study assessed the location of 887 infraorbital foramina from 518 adult crania of varied sex and population. The study assessed the midpoint of a line segment spanning from nasospinale to jugale (NS-J) relative to the infraorbital foramen. The mean distance of the NS-J midpoint from the infraorbital foramen was 2.1 ±â€Š1.9 mm (mean ±â€ŠSD) with a mode of 0 mm (266:887; 30%). The NS-J midpoint was located in the same plane or inferior to the infraorbital foramen in 98.4% of sides (873:887). There were no significant differences between sexes, populations, or sides with regard to the NS-J midpoint to infraorbital foramen distance. The NS-J midpoint can be used to locate the infraorbital foramen in both females and males of varied populations regardless of craniofacial diversity. The results of this study will aid in infraorbital nerve block procedures and maxillofacial surgery.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1097/SCS.0000000000004186

  8 / 39754 MEDLINE  
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[PMID]: 29315474
[Au] Autor:Herrick MD; Liu H; Davis M; Bell JE; Sites BD
[Ad] Address:Department of Anesthesiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
[Ti] Title:Regional anesthesia decreases complications and resource utilization in shoulder arthroplasty patients.
[So] Source:Acta Anaesthesiol Scand;62(4):540-547, 2018 Apr.
[Is] ISSN:1399-6576
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Regional anesthesia can be used as part of the anesthetic to optimize anesthesia and analgesia during shoulder arthroplasty, but little is known about the overall effect that regional anesthesia has on perioperative outcomes and resource utilization. We hypothesized that regional anesthesia may decrease complication rates and resource utilization in shoulder arthroplasty patients. METHODS: We examined administrative data from 588 US hospitals from 2010 to 2015. Logistic regression was used to examine the relationship between type of anesthesia and perioperative complications. RESULTS: Among patients who underwent shoulder arthroplasty, 79.1% (53,243) had general anesthesia alone, 17.8% (12,011) had general anesthesia and a nerve block, and 3.1% (2062) had a nerve block alone. Overall, the complication rate was 13.3% and 30-day mortality was 1.2 per 1000 (95% CI 0.9, 1.4). In adjusted analyses, patients who had general anesthesia alone (compared to general anesthesia and nerve block) had a 16% increase in all cause infectious complications (OR 1.16, 95% CI: 1.03, 1.31) and were 2.6 times more likely to develop pulmonary complications (OR 2.6, 95% CI: 1.14, 5.78). General anesthesia alone (relative to either block only or general anesthesia and block) was associated with substantial increases in the likelihood of blood transfusions, intensive care unit transfers, and prolonged length of stay. CONCLUSION: Patients receiving regional anesthesia for shoulder arthroplasty may have a reduction in perioperative complications, the need for intensive care unit transfers, blood transfusions, and prolonged hospital stays.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1111/aas.13063

  9 / 39754 MEDLINE  
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[PMID]: 29268648
[Au] Autor:Czarnetzki C; Rehberg B; Walder B
[Ad] Address:1 Service d'Anesthésiologie, Département d'Anesthésiologie, Soins Intensifs et Pharmacologie clinique, Hôpitaux Universitaires de Genève, Genf.
[Ti] Title:Moderne Anästhesie.
[So] Source:Ther Umsch;74(7):339-343, 2017.
[Is] ISSN:0040-5930
[Cp] Country of publication:Switzerland
[La] Language:ger
[Mh] MeSH terms primary: Anesthesia/methods
Anesthesia/trends
Anesthetics/administration & dosage
Monitoring, Intraoperative/methods
Nerve Block/methods
Pain, Postoperative/prevention & control
[Mh] MeSH terms secundary: Evidence-Based Medicine
Humans
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Anesthetics)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171223
[St] Status:MEDLINE
[do] DOI:10.1024/0040-5930/a000924

  10 / 39754 MEDLINE  
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[PMID]: 29268645
[Au] Autor:Kaviani R; Eichenberger U
[Ad] Address:1 Departement für Anästhesiologie, operative Intensivbehandlung, präklinische Notfallmedizin und Schmerztherapie, Universitätsspital Basel, Universität Basel, Basel.
[Ti] Title:Periphere Regionalanästhesie zur perioperativen Analgesie.
[So] Source:Ther Umsch;74(7):377-383, 2017.
[Is] ISSN:0040-5930
[Cp] Country of publication:Switzerland
[La] Language:ger
[Mh] MeSH terms primary: Anesthesia, Conduction/methods
Anesthetics, Local/administration & dosage
Nerve Block/methods
Pain, Postoperative/prevention & control
Patient Satisfaction
Perioperative Care/methods
Ultrasonography, Interventional/methods
[Mh] MeSH terms secundary: Evidence-Based Medicine
Humans
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Anesthetics, Local)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171223
[St] Status:MEDLINE
[do] DOI:10.1024/0040-5930/a000929


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