Database : MEDLINE
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[PMID]: 29524776
[Au] Autor:Gonçalves R; Brigagão JIM; Soares GCF
[Ad] Address:University of São Paulo, 1000 Av. Arlindo Bettio, São Paulo City, Brazil. Electronic address: roselane@usp.br.
[Ti] Title:Study circles in hospitals' obstetrics centers as a teaching-learning strategy in midwifery education.
[So] Source:Midwifery;61:42-44, 2018 Feb 15.
[Is] ISSN:1532-3099
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:We describe the experience of study circles on the theme 'good obstetrics practices backed by scientific evidence' and argue that they prepared midwifery students to dialogue with hospital staff and empowered them in the process of negotiating the implementation of practices put forward by the International Confederation of Midwives (ICM). We conclude that study circles are an efficient strategy of preparing midwifery students to be active participants in the maternity care team and lead discussions of evidenced-based practice.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 181838 MEDLINE  
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[PMID]: 29524725
[Au] Autor:Vaughan MH; Kim-Fine S; Hullfish KL; Smith TM; Siddiqui NY; Trowbridge ER
[Ad] Address:Department of Obstetrics & Gynecology, Division of Urogynecology and Reconstructive Pelvic Surgery, Duke University Medical Center, Durham, NC. Electronic address: monique.vaughan@duke.edu.
[Ti] Title:Validation of the Simulated Vaginal Hysterectomy Trainer (Simvaht).
[So] Source:J Minim Invasive Gynecol;, 2018 Mar 07.
[Is] ISSN:1553-4669
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:STUDY OBJECTIVE: To establish construct validity of the simulated vaginal hysterectomy trainer (SimVaHT). DESIGN: Cross-sectional validation study (Canadian Task Force classification II-2). SETTING: Single academic medical center in the United States. SUBJECTS: Fourteen residents in Obstetrics and Gynecology (four PGY-1, four PGY-2, three PGY-3 and three PGY-4). PGY-1 and PGY-2 residents were grouped to form the "junior level" cohort, while PGY-3 and PGY-4 residents comprised the "senior level" cohort. INTERVENTIONS: Each participant underwent surgical skill simulation by performing a simulated vaginal hysterectomy on a practical, inexpensive vaginal hysterectomy trainer. MEASUREMENTS AND MAIN RESULTS: The primary outcome was resident surgical skill as assessed by the Objective Structured Assessment of Technical Skills Global Rating Scale (GRS). All Obstetrics and Gynecology residents were videotaped performing a simulated vaginal hysterectomy on the SimVaHT. The tapes were reviewed independently by two blinded urogynecology experts, each of whom provided a GRS score. The primary outcome was overall GRS scores. Secondary outcome was time to complete the exercise. GRS scores were compared between junior and senior level residents. Senior level residents scored significantly higher on the GRS overall compared to junior level residents (p=0.008). CONCLUSION: Construct validity was demonstrated for the simulated vaginal hysterectomy trainer (SimVaHT). The SimVaHT is a practical and inexpensive tool that may improve resident vaginal surgical skills prior to their first case in the operating room.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 181838 MEDLINE  
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[PMID]: 29524677
[Au] Autor:Stanley C; Secter M; Chauvin S; Selk A
[Ad] Address:Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, M5S 1A8.
[Ti] Title:HPV Vaccination in Male Physicians: a survey of gynecologists and otolaryngology surgeons' attitudes towards vaccination in themselves and their patients.
[So] Source:Papillomavirus Res;, 2018 Mar 07.
[Is] ISSN:2405-8521
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Attitudes and barriers towards HPV vaccination were explored in a population of male surgeons in Gynecology and Otolaryngology in Ontario, Canada. MATERIALS/METHODS: An internet-based survey was distributed to male residents and physicians affiliated with the departments of Obstetrics and Gynecology, and Otolaryngology at six Ontario universities. The survey consisted of 16 questions (3 demographic, 3 workplace exposure, 6 regarding personal vaccination, and 3 regarding patient vaccination). Subgroup analyses examined differences between residents versus staff physicians and gynecologists versus otolaryngologists. RESULTS: Most respondents (51/63, 81.0%) had not been vaccinated against HPV, yet would consider vaccination in the future (41/51, 80.4%). Significantly more residents would consider vaccination compared to staff physicians (p=0.03). Personal protection from benign HPV disease was the most common motivating factor (25/59, 42.4%) among participants. A notable barrier to vaccination was "age over recommendations" (9/44, 20.4%). Most participants would recommend the HPV vaccine to both male patients (49/62, 79.0%) and male partners of female patients (47/62, 75.8%). CONCLUSIONS: This study demonstrates male gynecologists and otolaryngologists had largely favorable attitudes towards HPV vaccination though few had received vaccination. These findings may be used to increase HPV vaccine uptake among male health care professionals and their patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 181838 MEDLINE  
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[PMID]: 29524609
[Au] Autor:Yuk JS; Shin JY; Moon HS; Lee JH
[Ad] Address:Department of Obstetrics and Gynecology, Gyeongsang National University Changwon Hospital, School of Medicine, Gyeongsang National University, Changwon, Gyeongnam, Republic of Korea.
[Ti] Title:The incidence of unexpected uterine malignancy in women undergoing hysteroscopic myomectomy or polypectomy: A national population-based study.
[So] Source:Eur J Obstet Gynecol Reprod Biol;224:12-16, 2018 Mar 03.
[Is] ISSN:1872-7654
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The objective of this study was to investigate the incidence of unexpected uterine malignancy (UUM) diagnosed after hysteroscopic surgery for presumed submucosal leiomyomas or endometrial polyps. STUDY DESIGN: From the Korean national health insurance database between January 1, 2009 and December 31, 2015, we analyzed inpatient sample data that were extracted by a stratified random sampling (gender and age) method. We extracted women with or without UUM that was diagnosed after hysteroscopic surgery using diagnosis codes and procedure codes. RESULTS: A total of 11,866 women who underwent hysteroscopic surgery were extracted from 4,476,495 women. The mean age of the patients who underwent hysteroscopic surgery was 37.8 ±â€¯0.1 years. A hysteroscopic myomectomy or polypectomy was performed in 3498 and 8368 women, respectively. The incidence of UUM diagnosed after hysteroscopic myomectomy or polypectomy was 0.86% and 1.11%, respectively. The logistic regression analysis showed that the risk of UUM increased with age (Odds Ratio (OR), 1.61; 95% Confidence Interval (CI), 1.47-1.77; P < 0.001) and did not indicate hysteroscopic myomectomy or polypectomy (OR, 1.21; 95% CI, 0.93-1.55; P = 0.151). CONCLUSIONS: The incidence of UUM diagnosed after hysteroscopic myomectomy (0.86%) or polypectomy (1.11%) was higher than that of UUM diagnosed after hysterectomy (0.19%) or myomectomy (0.12%) for presumed benign leiomyoma. The incidence of UUM increased over the age of 50.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  5 / 181838 MEDLINE  
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[PMID]: 29432972
[Au] Autor:Zhou J; Zhang WW; Zhang QH; He ZY; Sun JY; Chen QH; Wu SG
[Ad] Address:Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People's Republic of China.
[Ti] Title:The effect of lymphadenectomy in advanced ovarian cancer according to residual tumor status: A population-based study.
[So] Source:Int J Surg;52:11-15, 2018 Feb 09.
[Is] ISSN:1743-9159
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: We investigated the effect of lymphadenectomy on the survival outcomes of patients with advanced epithelial ovarian cancer in the Surveillance, Epidemiology, and End Results database according to residual disease status. METHODS: We evaluated 3048 patients with International Federation of Gynecology and Obstetrics stage-IIIC-IV epithelial ovarian cancer. We assessed the effect of lymphadenectomy stratified by residual disease size on cause-specific survival (CSS). RESULTS: A total of 1904 (62.5%) patients received lymphadenectomy, and 1355 (71.2%) patients had nodal metastases. Lymph-node status had no significant association with residual tumor size in the lymphadenectomy group. In multivariate analysis, lymphadenectomy was associated with a significantly better CSS and was an independent prognostic factor for CSS. Patients with >10 lymph nodes removed had better CSS compared with non-lymphadenectomy and 1-10 lymph nodes removed groups. Lymphadenectomy was associated with a significantly better CSS in patients with no gross residual tumor, but not in patients with residual tumor ≤1 cm or >1 cm. CONCLUSIONS: Lymphadenectomy is significantly associated with a better survival outcome in patients advanced ovarian cancer, but its positive effect diminishes as residual tumor size increases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  6 / 181838 MEDLINE  
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[PMID]: 29523947
[Au] Autor:Safiri S; Ashrafi-Asgarabad A
[Ad] Address:Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran.
[Ti] Title:Does she have adnexal torsion? Prediction of adnexal torsion in reproductive age women: methodological issues.
[So] Source:Arch Gynecol Obstet;, 2018 Mar 09.
[Is] ISSN:1432-0711
[Cp] Country of publication:Germany
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s00404-018-4736-2

  7 / 181838 MEDLINE  
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[PMID]: 29523603
[Au] Autor:Ng YHG; Ee TX; Kanagalingam D; Tan HK
[Ad] Address:Singapore General Hospital, Singapore.
[Ti] Title:Resolution of severe fetal distress following treatment of maternal diabetic ketoacidosis.
[So] Source:BMJ Case Rep;2018, 2018 Mar 09.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Diabetic ketoacidosis (DKA) during pregnancy is a serious metabolic complication of diabetes with high mortality and morbidity if not detected and treated immediately. We report a case of a woman with type 1 diabetes mellitus who had poorly controlled diabetes in the first half of pregnancy and developed DKA at 29 weeks gestation. At presentation, she had a pathological fetal heart tracing but delivery was delayed for maternal stabilisation and reversal of acidosis. Once hyperglycaemia, acidosis and maternal stabilisation were achieved, fetal compromise resolved and delivery was no longer indicated. The patient was subsequently discharged home. She delivered vaginally a 2400 g baby at 34 weeks gestation after presenting with spontaneous rupture of membranes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process

  8 / 181838 MEDLINE  
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[PMID]: 29523392
[Au] Autor:Prefumo F; Rossi AC
[Ad] Address:Department of Obstetrics and Gynaecology, University of Brescia, Brescia, Italy. Electronic address: federico.prefumo@gmail.com.
[Ti] Title:Endometriosis, endometrioma, and ART results: Current understanding and recommended practices.
[So] Source:Best Pract Res Clin Obstet Gynaecol;, 2018 Feb 15.
[Is] ISSN:1532-1932
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Endometriosis and infertility are linked in a complex relationship, and a number of different pathogenetic mechanisms may associate the two. Endometriosis is diagnosed in 6-8% of women undergoing ART. Women with endometriosis appear to have similar ART outcomes compared to controls in terms of live birth rates, despite a lower oocyte quality. Laparoscopy should not be routinely performed before ART with the only aim to diagnose mild or moderate endometriosis, but if the latter is found, surgical removal can be considered, as it might improve pregnancy rates. In case of more severe forms of the disease (endometrioma and deep infiltrating endometriosis), the benefits of surgery before ART are uncertain and must be balanced against risks. Management decisions should be individualized based on patient choice, age, associated symptoms, and the risk of repeat surgery.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  9 / 181838 MEDLINE  
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[PMID]: 29523262
[Au] Autor:Louis JM; Koch MA; Reddy UM; Silver RM; Parker CB; Facco FL; Redline S; Nhan-Chang CL; Chung JH; Pien GW; Basner RC; Grobman WA; Wing DA; Simhan HN; Haas DM; Mercer BM; Parry S; Mobley D; Carper B; Saade GR; Schubert FP; Zee PC
[Ad] Address:Case Western Reserve University, Cleveland, OH. Electronic address: jlouis1@health.usf.edu.
[Ti] Title:Predictors of sleep-disordered breathing in pregnancy.
[So] Source:Am J Obstet Gynecol;, 2018 Feb 02.
[Is] ISSN:1097-6868
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Sleep-disordered breathing (SDB) is common in pregnancy, but there are limited data on predictors. OBJECTIVES: The objective of this study was to develop predictive models of sleep-disordered breathing during pregnancy. STUDY DESIGN: Nulliparous women completed validated questionnaires to assess for symptoms related to snoring, fatigue, excessive daytime sleepiness, insomnia, and restless leg syndrome. The questionnaires included questions regarding the timing of sleep and sleep duration, work schedules (eg, shift work, night work), sleep positions, and previously diagnosed sleep disorders. Frequent snoring was defined as self-reported snoring ≥3 days per week. Participants underwent in-home portable sleep studies for sleep-disordered breathing assessment in early (6-15 weeks gestation) and mid pregnancy (22-31 weeks gestation). Sleep-disordered breathing was characterized by an apnea hypopnea index that included all apneas, plus hypopneas with ≥3% oxygen desaturation. For primary analyses, an apnea hypopnea index ≥5 events per hour was used to define sleep-disordered breathing. Odds ratios and 95% confidence intervals were calculated for predictor variables. Predictive ability of the logistic models was estimated with area under the receiver-operating-characteristic curves, along with sensitivities, specificities, and positive and negative predictive values and likelihood ratios. RESULTS: Among 3705 women who were enrolled, data were available for 3264 and 2512 women in early and mid pregnancy, respectively. The corresponding prevalence of sleep-disordered breathing was 3.6% and 8.3%, respectively. At each time point in gestation, frequent snoring, chronic hypertension, greater maternal age, body mass index, neck circumference, and systolic blood pressure were associated most strongly with an increased risk of sleep-disordered breathing. Logistic regression models that included current age, body mass index, and frequent snoring predicted sleep-disordered breathing in early pregnancy, sleep-disordered breathing in mid pregnancy, and new onset sleep-disordered breathing in mid pregnancy with 10-fold cross-validated area under the receiver-operating-characteristic curves of 0.870, 0.838, and 0.809. We provide a supplement with expanded tables, integrated predictiveness, classification curves, and an predicted probability calculator. CONCLUSION: Among nulliparous pregnant women, logistic regression models with just 3 variables (ie, age, body mass index, and frequent snoring) achieved good prediction of prevalent and incident sleep-disordered breathing. These results can help with screening for sleep-disordered breathing in the clinical setting and for future clinical treatment trials.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  10 / 181838 MEDLINE  
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[PMID]: 29523224
[Au] Autor:Ye C; Hu Y; Wang J
[Ad] Address:Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
[Ti] Title:MicroRNA-377 targets zinc finger E-box-binding homeobox 2 to inhibit cell proliferation and invasion of cervical cancer.
[So] Source:Oncol Res;, 2018 Mar 09.
[Is] ISSN:1555-3906
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A large number of microRNAs (miRNAs) are aberrantly expressed in cervical cancer and play crucial roles in the onset and progression of cervical cancer by acting as either oncogene or tumor suppressor. Therefore, investigation on the expression, biological roles and underlying mechanisms of miRNAs in cervical cancer might provide valuable therapeutic targets in the treatment for patients with this disease. In this study, miRNA377 (miR-377) was downregulated in cervical cancer tissues and cell lines. Decreased miR-377 expression was strongly correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis and distant metastasis in patients with cervical cancer. Enhanced expression of miR-377 prohibited cell proliferation and invasion in cervical cancer. Bioinformatics analysis predicted that zinc finger E-box-binding homeobox 2 (ZEB2) was a potential target of miR-377. Subsequent experiments confirmed that ZEB2 is a direct target gene of miR-377 in cervical cancer. In addition, ZEB2 was overexpressed in cervical cancer tissues and was inversely related with miR-377 level. Furthermore, the suppressive effects of miR-377 on cervical cancer proliferation and invasion were rescued by restored ZEB2 expression. Overall, our findings indicated that miR-377 decreases proliferation and invasion of cervical cancer cells by directly targeting ZEB2 and provides novel evidence of miR-377 as a novel therapeutic strategy for the therapy of patients with this malignancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.3727/096504018X15201124340860


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