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[PMID]: 29186723
[Au] Autor:Cennamo G; Tebaldi S; Amoroso F; Arvanitis D; Breve M; Cennamo G
[Ad] Address:Eye Clinic, Department of Public Health, Federico II University, Naples, Italy.
[Ti] Title:Optical Coherence Tomography Angiography in Optic Nerve Drusen.
[So] Source:Ophthalmic Res;59(2):76-80, 2018.
[Is] ISSN:1423-0259
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:AIM: To determine the efficacy of optical coherence tomography angiography (OCT-A) in diagnosing optic nerve head flow impairment in patients with optic nerve drusen. METHODS: Patients affected by optic-nerve head drusen (ONHD) attending the Eye Clinic of the Federico II University of Naples were enrolled in this prospective case series between October 2015 and October 2016. Each patient underwent evaluation of best corrected visual acuity (BCVA), Goldman applanation tonometry, slit-lamp biomicroscopy, fundus examination, standard visual-field testing (perimetry), spectral domain (SD)-OCT and OCT-A. RESULTS: Thirteen patients (6 females and 7 males with a mean age of 22.05 ± 7.54 years) with ONHD (19 eyes) were enrolled. Mean BCVA was 0.16 ± 0.21 LogMar and mean intraocular pressure was 15.68 ± 1.66 mm Hg. The control group constituted 16 individuals (24 eyes). Both ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) parameters were lower in patients than in controls. Similarly, the flow index (U = 134, p = 0.021) and vessel density (U = 90, p = 0.001) were significantly lower in eyes affected by ONHD than in normal eyes. Visual-field parameters did not differ between the 2 groups. GCC parameters were significantly correlated with OCT-A parameters (p < 0.05). No correlation was found between RNFL and OCT-A parameters. CONCLUSIONS: Our data suggest that OCT-A could be an objective method, helpful in the analysis of flow changes in patients with ONHD.
[Mh] MeSH terms primary: Optic Disk Drusen/pathology
Optic Disk/pathology
[Mh] MeSH terms secundary: Adolescent
Adult
Female
Humans
Intraocular Pressure
Male
Nerve Fibers/pathology
Optic Disk/diagnostic imaging
Optic Disk Drusen/diagnostic imaging
Optic Disk Drusen/physiopathology
Prospective Studies
Retinal Ganglion Cells/pathology
Tomography, Optical Coherence
Visual Acuity
Visual Fields
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171130
[St] Status:MEDLINE
[do] DOI:10.1159/000481889

  2 / 576 MEDLINE  
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[PMID]: 28460051
[Au] Autor:Malmqvist L; Lindberg AW; Dahl VA; Jørgensen TM; Hamann S
[Ad] Address:Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.
[Ti] Title:Quantitatively Measured Anatomic Location and Volume of Optic Disc Drusen: An Enhanced Depth Imaging Optical Coherence Tomography Study.
[So] Source:Invest Ophthalmol Vis Sci;58(5):2491-2497, 2017 05 01.
[Is] ISSN:1552-5783
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Purpose: Optic disc drusen (ODD) are found in up to 2.4% of the population and are known to cause visual field defects. The purpose of the current study was to investigate how quantitatively estimated volume and anatomic location of ODD influence optic nerve function. Methods: Anatomic location, volume of ODD, and peripapillary retinal nerve fiber layer and macular ganglion cell layer thickness were assessed in 37 ODD patients using enhanced depth imaging optical coherence tomography. Volume of ODD was calculated by manual segmentation of ODD in 97 B-scans per eye. Anatomic characteristics were compared with optic nerve function using automated perimetric mean deviation (MD) and multifocal visual evoked potentials. Results: Increased age (P = 0.015); larger ODD volume (P = 0.002); and more superficial anatomic ODD location (P = 0.007) were found in patients with ODD visible by ophthalmoscopy compared to patients with buried ODD. In a multivariate analysis, a worsening of MD was significantly associated with larger ODD volume (P < 0.0001). No association was found between MD and weighted anatomic location, age, and visibility by ophthalmoscopy. Decreased ganglion cell layer thickness was significantly associated with worse MD (P = 0.025) and had a higher effect on MD when compared to retinal nerve fiber layer thickness. Conclusions: Large ODD volume is associated with optic nerve dysfunction. The worse visual field defects associated with visible ODD should only be ascribed to larger ODD volume and not to a more superficial anatomic ODD location.
[Mh] MeSH terms primary: Optic Disk Drusen/diagnosis
Optic Disk/pathology
Tomography, Optical Coherence/methods
Visual Fields
[Mh] MeSH terms secundary: Adult
Evoked Potentials, Visual
Female
Humans
Male
Nerve Fibers/pathology
Ophthalmoscopy
Optic Disk Drusen/physiopathology
Prospective Studies
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1707
[Cu] Class update date: 180124
[Lr] Last revision date:180124
[Js] Journal subset:IM
[Da] Date of entry for processing:170502
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21608

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[PMID]: 29084401
[Au] Autor:Pojda-Wilczek D; Wycislo-Gawron P
[Ad] Address:Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
[Ti] Title:The Effect of a Decrease in Intraocular Pressure on Optic Nerve Function in Patients with Optic Nerve Drusen.
[So] Source:Ophthalmic Res;, 2017 Oct 31.
[Is] ISSN:1423-0259
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:PURPOSE: The aim of the study was to compare optic nerve function in eyes with brinzolamide-reduced intraocular pressure (IOP) and the fellow eyes of patients with optic disk drusen (ODD). METHODS: The study comprised 34 patients with bilateral ODD but no signs of any other ocular disease. The eyes with more advanced optic neuropathy were selected for treatment with an IOP-lowering drug, carbonic anhydrase inhibitor (brinzolamide); the fellow eyes served as the control. Static perimetry, pattern electroretinography (PERG), pattern visual-evoked potentials (PVEP), and retinal nerve fiber layer (RNFL) thickness were analyzed. The observation period was 12 months. RESULTS: The eyes with brinzolamide-reduced IOP exhibited a statistically significant decrease in the mean defect index of static visual field (p = 0.03), an increase in PERG N95 amplitude (from 2.94 to 4.41 µV; p = 0.0047), and RNFL thickness stabilization. A statistically significant decrease in RNFL thickness (from 83.21 to 79.85 µm; p = 0.0017) was found in the control eyes. CONCLUSIONS: A decrease in IOP in eyes with ODD results in improvement of retinal ganglion cell function and delays the progression of optic neuropathy. PERG should be performed in patients with ODD as it is a sensitive test for monitoring optic neuropathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[St] Status:Publisher
[do] DOI:10.1159/000481534

  4 / 576 MEDLINE  
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[PMID]: 28659124
[Au] Autor:Allegrini D; Penco S; Pece A; Autelitano A; Montesano G; Paci S; Montanari C; Maver A; Peterlin B; Damante G; Rossetti L
[Ad] Address:Eye Unit, Humanitas Gavazzeni Hospital, Humanitas University, Bergamo, Italy. davideallegrini@yahoo.it.
[Ti] Title:Cataract and optic disk drusen in a patient with glycogenosis and di George syndrome: clinical and molecular report.
[So] Source:BMC Ophthalmol;17(1):107, 2017 Jun 28.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: We report the ophthalmic findings of a patient with type Ia glycogen storage disease (GSD Ia), DiGeorge syndrome (DGS), cataract and optic nerve head drusen (ONHD). CASE PRESENTATION: A 26-year-old white woman, born at term by natural delivery presented with a post-natal diagnosis of GSD Ia. Genetic testing by array-comparative genomic hybridization (CGH) for DGS was required because of her low levels of serum calcium. The patient has been followed from birth, attending the day-hospital every six months at the San Paolo Hospital, Milan, outpatient clinic for metabolic diseases and previously at another eye center. During the last day-hospital visit, a complete eye examination showed ONHD and cataract in both eyes. Next Generation Sequencing (NGS) was subsequently done to check for any association between the eye problems and metabolic aspects. CONCLUSIONS: This is the first description of ocular changes in a patient with GSD Ia and DGS. Mutations explaining GSD Ia and DGS were found but no specific causative mutation for cataract and ONHD. The metabolic etiology of her lens changes is known, whereas the pathogenesis of ONHD is not clear. Although the presence of cataract and ONHD could be a coincidence; the case reported could suggest that hypocalcemia due to DGS could be the common biochemical pathway.
[Mh] MeSH terms primary: Cataract/etiology
DiGeorge Syndrome/complications
Glycogen Storage Disease/complications
Optic Disk Drusen/etiology
Visual Fields
[Mh] MeSH terms secundary: Adult
Cataract/diagnosis
Comparative Genomic Hybridization
DiGeorge Syndrome/diagnosis
Female
Glycogen Storage Disease/diagnosis
High-Throughput Nucleotide Sequencing
Humans
Optic Disk Drusen/diagnosis
Tomography, Optical Coherence
Visual Acuity
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171004
[Lr] Last revision date:171004
[Js] Journal subset:IM
[Da] Date of entry for processing:170630
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0499-y

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[PMID]: 28564702
[Au] Autor:Garg A; Blumberg DM; Al-Aswad LA; Oll M; Yzer S; Forbes M; Allikmets RL; Bearelly S
[Ad] Address:Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York, United States.
[Ti] Title:Associations Between ß-Peripapillary Atrophy and Reticular Pseudodrusen in Early Age-Related Macular Degeneration.
[So] Source:Invest Ophthalmol Vis Sci;58(5):2810-2815, 2017 May 01.
[Is] ISSN:1552-5783
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Purpose: Choroidal thinning has been associated with reticular pseudodrusen (RPD) and ß-peripapillary atrophy (ß-PPA), which have been linked to normal-tension glaucoma (NTG). This analysis sought to determine whether RPD are independently associated with ß-PPA in early AMD patients. Secondary outcomes included the association of RPD and preexisting diagnosis of glaucoma, cup-to-disc ratio (CDR), subfoveal choroidal thickness (SFCT), and IOP. Methods: This prospective cross-sectional study examined 78 age- and sex-matched early AMD patients: 43 RPD patients (63 eyes) and 35 non-RPD patients (64 eyes). Exclusion criteria included advanced AMD, high myopia, and vitreoretinal conditions/surgery. RPD and non-RPD groups were identified by confocal scanning laser ophthalmoscopy. ß-PPA as well as CDR were graded on digital, nonstereoscopic fundus photos. SFCT was measured on spectral-domain optical coherence tomography for 69 patients (35 RPD and 34 non-RPD). IOP and glaucoma diagnosis were extracted from charts. Results: ß-PPA had a greater prevalence in RPD than non-RPD (44% vs. 19%, P = 0.002); however, this relationship was not significant when SFCT was added to the model (P = 0.150). A preexisting diagnosis of glaucoma (P = 0.156), CDR (P = 0.176), and IOP (P = 0.98) was not different between groups. Conclusions: RPD in early AMD are associated with presence of ß-PPA, but choroidal thickness is a confounder in this relationship. Because ß-PPA is a common finding in NTG, focusing on a potential shared pathway between RPD and NTG could improve the understanding of pathophysiology and expand therapies for each condition.
[Mh] MeSH terms primary: Geographic Atrophy/diagnosis
Glaucoma/diagnosis
Optic Atrophy/diagnosis
Retinal Drusen/diagnosis
[Mh] MeSH terms secundary: Aged
Aged, 80 and over
Choroidal Neovascularization/pathology
Cross-Sectional Studies
Female
Fluorescein Angiography
Humans
Intraocular Pressure
Male
Ophthalmoscopy
Optic Disk/pathology
Prospective Studies
Tomography, Optical Coherence/methods
Visual Acuity
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170717
[Lr] Last revision date:170717
[Js] Journal subset:IM
[Da] Date of entry for processing:170601
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20343

  6 / 576 MEDLINE  
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[PMID]: 28141766
[Au] Autor:Chien JL; Sioufi K; Surakiatchanukul T; Shields JA; Shields CL
[Ad] Address:Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
[Ti] Title:Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes.
[So] Source:Curr Opin Ophthalmol;28(3):228-237, 2017 May.
[Is] ISSN:1531-7021
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE OF REVIEW: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus. RECENT FINDINGS: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. The prevalence of choroidal nevus in postequatorial region in United States adults (≥40 years old) is approximately 5%. Choroidal nevus is associated with higher lifetime unopposed estrogen and greater BMI. In population-based evaluation, the mean nevus basal dimension is approximately 1.25 mm. Giant nevus (basal dimension ≥10 mm) carries greater risk for malignant transformation. Imaging modalities for evaluation of choroidal nevus include ultrasonography, fundus autofluorescence, and optical coherence tomography (OCT). Fluorescein angiography is occasionally employed to detect multifocal pinpoint leaks or choroidal neovascular membrane. Recently, OCT angiography demonstrated nevus with minimal overlying macular microvascular changes compared with melanoma. Cytogenetically, GNA11 or GNAQ mutations have been documented in uveal melanoma in 83% and in some cutaneous nevus subtypes. Further mutations lead to the development of melanoma at a rate of one of 8845 cases. Risk factors for transformation of nevus into melanoma are recalled by the mnemonic 'To find small ocular melanoma using helpful hints daily' representing thickness (T) more than 2 mm, subretinal fluid (F), symptoms (S) of flashes/floaters/blurred vision, orange (O) lipofuscin pigment, margin (M) less than 3 mm from optic disk, ultrasonographic hollowness (UH), halo (H) absence, and drusen (D) absence. The presence of three or more risk factors implies more than 50% chance for transformation to melanoma within 5 years. A new, online ocular oncology reading center can help judge nevus risk. SUMMARY: Choroidal nevus is a common intraocular lesion, found predominantly in Whites. This mass carries a small risk (<1%) for malignant transformation. Patients with at least three risk factors should be evaluated for possible melanoma at an experienced ocular oncology center.
[Mh] MeSH terms primary: Choroid Neoplasms
Nevus, Pigmented
[Mh] MeSH terms secundary: Choroid Neoplasms/diagnosis
Choroid Neoplasms/epidemiology
Choroid Neoplasms/genetics
Cytogenetics
Fluorescein Angiography
GTP-Binding Protein alpha Subunits/genetics
GTP-Binding Protein alpha Subunits, Gq-G11/genetics
Humans
Nevus, Pigmented/diagnosis
Nevus, Pigmented/epidemiology
Nevus, Pigmented/genetics
Prevalence
Prognosis
Risk Factors
United States/epidemiology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (GNA11 protein, human); 0 (GNAQ protein, human); 0 (GTP-Binding Protein alpha Subunits); EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gq-G11)
[Em] Entry month:1704
[Cu] Class update date: 170418
[Lr] Last revision date:170418
[Js] Journal subset:IM
[Da] Date of entry for processing:170201
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000361

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[PMID]: 28139892
[Au] Autor:Malmqvist L; de Santiago L; Boquete L; Hamann S
[Ad] Address:Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.
[Ti] Title:Multifocal visual evoked potentials for quantifying optic nerve dysfunction in patients with optic disc drusen.
[So] Source:Acta Ophthalmol;95(4):357-362, 2017 Jun.
[Is] ISSN:1755-3768
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: To explore the applicability of multifocal visual evoked potentials (mfVEPs) for research and clinical diagnosis in patients with optic disc drusen (ODD). This is the first assessment of mfVEP amplitude in patients with ODD. METHODS: MfVEP amplitude and latency from 33 patients with ODD and 22 control subjects were examined. Mean amplitude, mean inner ring (IR) amplitude (0.87-5.67° of visual field) and mean outer ring amplitude (5.68-24° of visual field) were calculated using signal-to-noise ratio (SNR) and peak-to-peak analysis. Monocular latency was calculated using second peak analysis, while latency asymmetry was calculated using cross-correlation analysis. RESULTS: Compared to normals, significantly decreased mean overall amplitude (p < 0.001), IR amplitude (p < 0.001) and outer ring amplitude (p < 0.001) were found in ODD patients when using SNR. An overall monocular latency delay of 7 ms was seen in ODD patients (p = 0.001). A significant correlation between amplitude and automated perimetric mean deviation as well as retinal nerve fibre layer thickness was found (respectively, p < 0.001 and p = 0.003). The overall highest correlation was found in this order: outer ring, full eye and IR. In the control group, SNR intersubject variability was 17.6% and second peak latency intersubject variability was 2.8%. CONCLUSION: Decreased mfVEP amplitude in patients with ODD suggests a direct mechanical compression of the optic nerve axons. Our results suggest that mfVEP amplitude is applicable for the assessment of optic nerve dysfunction in patients with ODD.
[Mh] MeSH terms primary: Evoked Potentials, Visual/physiology
Optic Disk Drusen/diagnosis
Optic Nerve/physiopathology
Visual Fields
[Mh] MeSH terms secundary: Adult
Aged
Female
Follow-Up Studies
Humans
Male
Middle Aged
Optic Disk Drusen/physiopathology
Optic Nerve/pathology
Reproducibility of Results
Retrospective Studies
Tomography, Optical Coherence/methods
Visual Field Tests
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170929
[Lr] Last revision date:170929
[Js] Journal subset:IM
[Da] Date of entry for processing:170201
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13347

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[PMID]: 28088509
[Au] Autor:Serra R; Coscas F; Messaoudi N; Srour M; Souied E
[Ad] Address:Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France; Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy.
[Ti] Title:Choroidal Neovascularization in Malattia Leventinese Diagnosed Using Optical Coherence Tomography Angiography.
[So] Source:Am J Ophthalmol;176:108-117, 2017 Apr.
[Is] ISSN:1879-1891
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To compare optical coherence tomography angiography (OCT-A) with traditional multimodal imaging in patients with Malattia Leventinese. DESIGN: Retrospective case series. METHODS: Eight eyes of 4 consecutive patients with Malattia Leventinese were retrospectively studied. All patients underwent a complete ophthalmologic examination including color fundus photography, fluorescein and indocyanine green angiographies, spectral-domain optical coherence tomography, and optical coherence tomography angiography. RESULTS: The choriocapillaris segmentation of OCT-A revealed the presence of a hyperflow signal corresponding to active choroidal neovascularization in 3 eyes and inactive choroidal neovascularization in 1 eye. Traditional multimodal imaging did not show each vascular layer and any leakage in these cases. CONCLUSION: OCT-A, unlike traditional multimodal imaging, helps diagnose choroidal neovascularization in patients with Malattia Leventinese suffering from metamorphopsia and reduced visual acuity.
[Mh] MeSH terms primary: Choroid/diagnostic imaging
Choroidal Neovascularization/diagnosis
Fluorescein Angiography/methods
Retina/diagnostic imaging
Tomography, Optical Coherence/methods
[Mh] MeSH terms secundary: Choroidal Neovascularization/etiology
Female
Fundus Oculi
Humans
Male
Middle Aged
Optic Disk Drusen/complications
Optic Disk Drusen/congenital
Optic Disk Drusen/diagnosis
Reproducibility of Results
Retrospective Studies
Visual Acuity
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170508
[Lr] Last revision date:170508
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170116
[St] Status:MEDLINE

  9 / 576 MEDLINE  
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[PMID]: 28084042
[Au] Autor:Lee KM; Woo SJ; Hwang JM
[Ad] Address:Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
[Ti] Title:Differentiation between optic disc drusen and optic disc oedema using fundus photography.
[So] Source:Acta Ophthalmol;95(4):e329-e335, 2017 Jun.
[Is] ISSN:1755-3768
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: To describe a funduscopic sign that can be used to differentiate between optic disc drusen (ODD) and optic disc oedema (ODE). METHODS: A total of 73 eyes from 73 consecutive subjects with disc margin blurring who had been evaluated using spectral-domain optical coherence tomography (SD-OCT) were included. Final diagnosis was made by SD-OCT; ODD was defined by direct visualization of ODD, while ODE was defined by documentation of retinal nerve fibre layer oedema (nasal retinal nerve fibre layer thickness >78.0 µm). Peripapillary retina was selected as a two-disc-diameter-sized square image from the fundus photograph. Using MATLAB software, colour photographs were converted to indexed image of eight colours. Presence of a smooth contour strip between the nasal disc margin and juxtapapillary retina was defined as a halo. Whether the halo could predict the ODD was analysed retrospectively. RESULTS: The halo sign was detected in 45 eyes (100%) with ODD including one eye with both ODD and ODE. No eyes with ODE alone showed the halo sign. The halo sign implied the presence of ODD (Cohen's kappa = 1.000, p < 0.001) and the absence of ODE (Cohen's kappa = 0.971, p < 0.001). The halo sign showed a good interobserver reliability [ICC (2, 1) = 0.944, 95% confidence interval 0.912-0.964]. SD-OCT images showed that halos represented retinal elevations above ODD. CONCLUSIONS: In the patients with blurred disc margin, the presence of a halo strongly suggested underlying ODD rather than ODE.
[Mh] MeSH terms primary: Nerve Fibers/pathology
Optic Disk Drusen/diagnosis
Optic Disk/pathology
Papilledema/diagnosis
Photography/methods
Retinal Ganglion Cells/pathology
Tomography, Optical Coherence/methods
[Mh] MeSH terms secundary: Adult
Diagnosis, Differential
Female
Follow-Up Studies
Humans
Male
Middle Aged
Reproducibility of Results
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170929
[Lr] Last revision date:170929
[Js] Journal subset:IM
[Da] Date of entry for processing:170114
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13338

  10 / 576 MEDLINE  
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[PMID]: 27996202
[Au] Autor:Malmqvist L; Lund-Andersen H; Hamann S
[Ad] Address:Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.
[Ti] Title:Long-term evolution of superficial optic disc drusen.
[So] Source:Acta Ophthalmol;95(4):352-356, 2017 Jun.
[Is] ISSN:1755-3768
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: Optic disc drusen (ODD) is hyaline deposits in the optic nerve head seen in 1-2% of the population. Long-term evolution of ODD anatomy and visual field defects in ODD patients is a key factor for learning more about pathophysiology and prognosis of the condition. With a median follow-up period of 56 years, this is the first study that evaluates superficial optic disc anatomy and visual fields in patients with ODD over a life span. METHODS: Observational case series investigating progression of superficial optic disc anatomy and visual fields in ODD patients. Eight patients with hereditary ODD were included. RESULTS: Mean age at initial and follow-up examination was, respectively, 16.8 and 73.3 years. The median follow-up time was 56 years. A minimal or non-existing change in superficial ODD anatomy (size and number) was seen in 10 of 12 eyes. There was a tendency towards more anatomical change in subjects younger at first examination. A 27% decrease in Goldmann perimetric visual field area (cm ) was found between initial and follow-up examinations. CONCLUSION: Minimal or no change in superficial optic disc anatomy and visual fields in ODD patients oldest at the initial examination suggests that anatomical progression of ODD in patients with hereditary ODD happens primarily before adulthood.
[Mh] MeSH terms primary: Forecasting
Ophthalmoscopy/methods
Optic Disk Drusen/diagnosis
Optic Disk/pathology
Visual Acuity
Visual Fields
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Disease Progression
Female
Follow-Up Studies
Humans
Male
Middle Aged
Optic Disk Drusen/physiopathology
Young Adult
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Entry month:1709
[Cu] Class update date: 170929
[Lr] Last revision date:170929
[Js] Journal subset:IM
[Da] Date of entry for processing:161221
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13315


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