Database : MEDLINE
Search on : organophosphate and poisoning [Words]
References found : 2920 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 292 go to page                         

  1 / 2920 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29516527
[Au] Autor:Vanova N; Pejchal J; Herman D; Dlabkova A; Jun D
[Ad] Address:Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.
[Ti] Title:Oxidative stress in organophosphate poisoning: role of standard antidotal therapy.
[So] Source:J Appl Toxicol;, 2018 Mar 08.
[Is] ISSN:1099-1263
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Despite the main mechanism of organophosphate (OP) toxicity through inhibition of acetylcholinesterase (AChE) being well known over the years, some chronic adverse health effects indicate the involvement of additional pathways. Oxidative stress is among the most intensively studied. Overstimulation of cholinergic and glutamatergic nervous system is followed by intensified generation of reactive species and oxidative damage in many tissues. In this review, the role of oxidative stress in pathophysiology of OP poisoning and the influence of commonly used medical interventions on its levels are discussed. Current standardized therapy of OP intoxications comprises live-saving administration of the anticholinergic drug atropine accompanied by oxime AChE reactivator and diazepam. The capability of these antidotes to ameliorate OP-induced oxidative stress varies between both therapeutic groups and individual medications within the drug class. Regarding oxidative stress, atropine does not seem to have a significant effect on oxidative stress parameters in OP poisoning. In a case of AChE reactivators, pro-oxidative and antioxidative properties could be found. It is assumed that the ability of oximes to trigger oxidative stress is rather associated with their chemical structure than reactivation efficacy. The data indicating the potency of diazepam in preventing OP-induced oxidative stress are not available. Based on current knowledge on the mechanism of OP-mediated oxidative stress, alternative approaches (including antioxidants or multifunctional drugs) in therapy of OP poisoning are under consideration.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1002/jat.3605

  2 / 2920 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29230717
[Au] Autor:Blumenberg A; Benabbas R; deSouza IS; Conigliaro A; Paladino L; Warman E; Sinert R; Wiener SW
[Ad] Address:Department of Emergency Medicine, Downstate Medical Center, State University of New York, Albany, NY, USA.
[Ti] Title:Utility of 2-Pyridine Aldoxime Methyl Chloride (2-PAM) for Acute Organophosphate Poisoning: A Systematic Review and Meta-Analysis.
[So] Source:J Med Toxicol;, 2017 Dec 11.
[Is] ISSN:1937-6995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Organophosphates (OP) account for the majority of pesticide-related unintentional or intentional poisonings in lower- and middle-income countries. The therapeutic role of atropine is well-established for patients with acute OP poisoning. The benefit of adding 2-pyridine aldoxime methyl chloride (2-PAM), however, is controversial. We performed a systematic review and meta-analysis of available randomized controlled trials (RCT) to compare 2-PAM plus atropine in comparison to atropine alone for acute OP poisoning. We searched PubMed, EMBASE, and SCOPUS up to March 2017. The Cochrane review handbook was used to assess the risk of bias. Data were abstracted and risk ratios (RR) were calculated for mortality, rate of intubation, duration of intubation, intermediate syndrome, and complications such as hospital-acquired infections, dysrhythmias, and pulmonary edema. We found five studies comprising 586 patients with varying risks of bias. The risk of death (RR = 1.5, 95% CI 0.9-2.5); intubation (RR = 1.3, 95% CI 1.0-1.6); intermediate syndrome (RR = 1.6, 95% CI 1.0-2.6); complications (RR = 1.2, 95% CI 0.8-1.8); and the duration of intubation (mean difference 0.0, 95% CI - 1.6-1.6) were not significantly different between the atropine plus 2-PAM and atropine alone. Based on our meta-analysis of the available RCTs, 2-PAM was not shown to improve outcomes in patients with acute OP poisoning.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher
[do] DOI:10.1007/s13181-017-0636-2

  3 / 2920 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29299760
[Au] Autor:Blumenberg A; Benabbas R; de Souza I; Conigliaro A; Paladino L; Warman E; Sinert R; Wiener SW
[Ad] Address:Department of Emergency Medicine, SUNY Downstate Medical Center, Brooklyn, USA.
[Ti] Title:Correction to: Utility of 2-Pyridine Aldoxime Methyl Chloride (2-PAM) for Acute Organophosphate Poisoning: A Systematic Review and Meta-Analysis.
[So] Source:J Med Toxicol;, 2018 Jan 03.
[Is] ISSN:1937-6995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The names of coauthors Roshanak Benabbas and and Ian S. deSouza were given incorrectly (as "Roshnak Benabbas" and "Ian de Souza", respectively) in this article as originally published.
[Pt] Publication type:PUBLISHED ERRATUM
[Em] Entry month:1801
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.1007/s13181-017-0648-y

  4 / 2920 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28743514
[Au] Autor:Herbert J; Thiermann H; Worek F; Wille T
[Ad] Address:Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany.
[Ti] Title:Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning.
[So] Source:Toxicology;389:94-100, 2017 08 15.
[Is] ISSN:1879-3185
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Standard therapeutic options in organophosphate (OP) poisoning are limited to the administration of atropine and oximes, a regimen often lacking in efficacy and applicability. Treatment alternatives are needed, preferably covering a broad spectrum of OP intoxications. Although recent research yielded several promising compounds, e.g. bioscavengers, modulators of the muscarinic acetylcholine (ACh) receptor or bispyridinium non-oximes, these substances still need further evaluation, especially regarding effects on the potentially lethal respiratory symptoms of OP poisoning. Aim of this study was the development of an applicable and easy method to test the therapeutic efficiency of such substances. For this purpose, airway responsiveness in viable precision cut lung slices (PCLS) from rats was analysed. We showed that ACh-induced airway contractions were spontaneously reversible in non-poisoned PCLS, whereas in OP poisoned PCLS, contractions were irreversible. This effect could be antagonized by addition of the standard therapeutic atropine, thereby presenting a clear indication for treatment efficiency. Now, candidate therapeutic compounds can be evaluated, based on their ability to counteract the irreversible airway contraction in OP poisoned PCLS.
[Mh] MeSH terms primary: Antidotes/pharmacology
Atropine/pharmacology
Bronchoconstriction/drug effects
Bronchodilator Agents/pharmacology
Drug Discovery/methods
Lung/drug effects
Muscarinic Antagonists/pharmacology
Muscle Contraction/drug effects
Muscle, Smooth/drug effects
Nerve Agents/toxicity
Organophosphate Poisoning/drug therapy
Organophosphates/toxicity
[Mh] MeSH terms secundary: Acetylcholine/pharmacology
Animals
Dose-Response Relationship, Drug
Lung/physiopathology
Male
Muscle, Smooth/physiopathology
Organophosphate Poisoning/physiopathology
Rats, Wistar
Time Factors
Tissue Culture Techniques
Tissue Survival
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antidotes); 0 (Bronchodilator Agents); 0 (Muscarinic Antagonists); 0 (Nerve Agents); 0 (Organophosphates); 7C0697DR9I (Atropine); N9YNS0M02X (Acetylcholine)
[Em] Entry month:1709
[Cu] Class update date: 180122
[Lr] Last revision date:180122
[Js] Journal subset:IM
[Da] Date of entry for processing:170727
[St] Status:MEDLINE

  5 / 2920 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29332674
[Au] Autor:Baumert BO; Carnes MU; Hoppin JA; Jackson CL; Sandler DP; Freeman LB; Henneberger PK; Umbach DM; Shrestha S; Long S; London SJ
[Ad] Address:Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
[Ti] Title:Sleep apnea and pesticide exposure in a study of US farmers.
[So] Source:Sleep Health;4(1):20-26, 2018 Feb.
[Is] ISSN:2352-7226
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Carbamate and organophosphate pesticides inhibit acetylcholinesterase, and poisoning leads to respiratory depression. Thus, involvement in sleep apnea is plausible, but no data exist at lower levels of exposure. Other pesticides could impact sleep apnea by different mechanisms but have not been studied. Our study examines the associations between pesticide exposure and sleep apnea among pesticide applicators from a US farming population. PARTICIPANTS AND METHODS: We analyzed data from 1569 male pesticide applicators, mostly farmers, from an asthma case-control study nested within the prospective Agricultural Health Study. On questionnaires, participants reported use of specific pesticides and physician diagnosis plus prescribed treatments for sleep apnea. We used multivariable logistic regression to estimate associations between ever use of 63 pesticides and sleep apnea (234 cases, 1335 noncases). RESULTS: The most notable association was for carbofuran, a carbamate (100 exposed cases, odds ratio 1.83, 95% confidence interval 1.34-2.51, P=.0002). Carbofuran use began before reported onset of sleep apnea in all cases. DISCUSSION: This study adds to the known adverse health outcomes of exposure to carbofuran, a pesticide canceled in the United States in 2009 for most agricultural purposes but persists in the environment and remains in use in some other countries. CONCLUSIONS: We conducted the first epidemiological study investigating the association of pesticide exposure and sleep apnea. Our results in a male agricultural population suggests that exposure to carbofuran is positively associated with sleep apnea.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180119
[Lr] Last revision date:180119
[St] Status:In-Data-Review

  6 / 2920 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29317766
[Au] Autor:Jeon U; Park S; Park S; Lee EY; Gil HW
[Ad] Address:Department of Internal medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.
[Ti] Title:Clinical characteristics of stress cardiomyopathy in patients with acute poisoning.
[So] Source:Sci Rep;8(1):223, 2018 Jan 09.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Patients who attempt intentional suicide suffer from physical or emotional stress. This situation might be an important factor that causes takotsubo cardiomyopathy. We retrospectively investigated the clinical features of Takotsubo cardiomyopathy in patients with acute poisoning. This study included patients who were admitted from January 2010 to December 2015 because of intentional poisoning by ingestion. Among these patients, we selectively collected data of patients who underwent an echocardiogram. We divided the patients into three groups according to the echocardiogram; the non-cardiomyopathy group, the global hypokinesia group, and the takotsubo cardiomyopathy group. One hundred forty-seven patients were analyzed in this study. One hundred thirty-one patients had normal cardiac function without regional wall motion abnormality. Global hypokinesia was observed in five patients. The overall incidence of takotsubo cardiomyopathy was 7.5% (11/147). Levels of cardiac enzymes including CK-MB, Troponin T, a marker of cardiac muscle ischemia, were higher in the global hypokinesia group and the takotsubo cardiomyopathy group compared with the non-cardiomyopathy group. The most commonly consumed poison was organophosphate in the takotsubo cardiomyopathy group. In conclusion, takotsubo cardiomyopathy may be one of the cardiac complications in patients who attempt suicide by consuming a poison.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180119
[Lr] Last revision date:180119
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-017-18478-5

  7 / 2920 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29332594
[Au] Autor:Soukup O; Korabecny J; Malinak D; Nepovimova E; Pham NL; Musilek K; Hrabinova M; Hepnarova V; Dolezal R; Pavek P; Jost P; Kobrlova T; Jankockova J; Gorecki L; Psotka M; Nguyen TD; Box K; Outhwaite B; Ceckova M; Sofr A; Jun D; Kuca K
[Ad] Address:Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove. Czech Republic.
[Ti] Title:In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning - a new hope or a blind alley?
[So] Source:Med Chem;, 2018 Jan 11.
[Is] ISSN:1875-6638
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: In the last decade, the concept of uncharged reactivators potentially able to penetrate the CNS has been introduced as an alternative to the classic charged oxime reactivators. However, this concept brings with it several associated drawbacks such as higher lipophilicity, difficulty in administration, lower affinity to cholinesterases, and higher toxicity risk. OBJECTIVE: In this study we compare data obtained for a set of five classic charged reactivators and a set of three recently published uncharged oximes supplemented by two novel ones. METHODS: This time, we used only in silico prediction and in vitro approaches. RESULTS: Our data showed that uncharged oximes have low affinity for cholinesterases, do not possess high reactivation potency, and certainly represent a greater toxicity risk due to higher lipophilicity. We assume that balanced physicochemical properties will be required for the successful treatment of OP poisoning. Nevertheless, the compound meeting such criteria and pinpointed in silico (K1280) failed in this particular case. CONCLUSION: From the presented data, it is clear that the concept of uncharged reactivators will have to be modified, at least to improve the bioavailability and to satisfy requirements for in vivo administration.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180115
[Lr] Last revision date:180115
[St] Status:Publisher
[do] DOI:10.2174/1573406414666180112105657

  8 / 2920 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29233034
[Au] Autor:Lee SB; Kang C; Kim DH; Kim T; Lee SH; Jeong JH; Kim SC; Rhee DY; Lim D
[Ad] Address:1 Department of Emergency Medicine, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
[Ti] Title:Base deficit is a predictor of mortality in organophosphate insecticide poisoning.
[So] Source:Hum Exp Toxicol;37(2):118-124, 2018 Feb.
[Is] ISSN:1477-0903
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Organophosphate insecticide (OPI) self-poisoning is a major medical problem in many countries. Several studies have demonstrated that the base deficit (BD) is a prognostic tool that is correlated with the severity of injury and predicted mortality, particularly in trauma patients. Here, we aimed to investigate the prognostic significance of BD in OPI poisoning. METHODS: This retrospective observational study was conducted between January 1, 2006, and January 31, 2015, at a single emergency department (ED). The BD values were divided into quartiles according to the number of patients: 3 mEq/L or less, 3-5.9 mEq/L, 6-9.9 mEq/L, and 10 mEq/L or greater. Survival at 30 days from ED admission was estimated using the Kaplan-Meier survival analysis. RESULTS: Among 154 patients, 31 died, yielding a mortality of 20.1%. The highest BD quartile (≥ 10 mEq/L) and the 6-9.9 mEq/L group were associated with an increased risk of 30-day mortality. Patients with a BD of 10 mEq/L or greater had a 5.85-fold higher risk of 30-day mortality and patients with a BD of 6-9.9 mEq/L had a 5.40-fold higher risk of 30-day mortality compared to patients with a BD of 3 mEq/L or less. The area under the curves of the BD and the Acute Physiology and Chronic Health Evaluation II score for mortality were 0.748 (95% confidence interval (CI), 0.660-0.835) and 0.852 (95% CI, 0.789-0.915), respectively. CONCLUSIONS: This study showed that the BD is a predictor of 30-day mortality in patients with OPI poisoning.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180111
[Lr] Last revision date:180111
[St] Status:In-Process
[do] DOI:10.1177/0960327117694073

  9 / 2920 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29307370
[Au] Autor:Gundogan K; Donmez-Altuntas H; Hamurcu Z; Akbudak IH; Sungur M; Bitgen N; Baskol G; Bayram F
[Ad] Address:Intensive Care Unit, Department of Internal Medicine, Medical Faculty, Erciyes University, Kayseri, Turkey.
[Ti] Title:Evaluation of chromosomal DNA damage, cytotoxicity, cytostasis, oxidative DNA damage and their relationship with endocrine hormones in patients with acute organophosphate poisoning.
[So] Source:Mutat Res;825:1-7, 2018 Jan.
[Is] ISSN:1873-135X
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Pesticides are commonly used compounds in agriculture. Especially, organophosphates (OPs) are among the extensively used pesticides. Therefore, OPs poisoning is common, especially in underdeveloped and developing countries. Primary aim of this study was to research the effects of acute OPs poisoning on genome instability in the individuals' lymphocytes with acute OPs poisoning both by using the cytokinesis-block micronucleus cytome (CBMN-cyt) assay to examine chromosome/genome damage, cell proliferation index and cell death rate and by using the plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels to determine oxidative DNA damage. Secondary aim of this study was also to assess whether a relation exists between endocrine hormones and the genome damage in acute OPs poisoning. In the study, blood samples were analysed of 13 patients before and after treatment admitted to the Department of Intensive Care Unit with acute OPs poisoning and of 13 healthy subjects of similar age and sex. The present study demonstrates that genome damage (micronucleus; MN and nucleoplasmic bridges; NPBs frequencies), apoptotic and necrotic cell frequencies increased in lymphocytes of patients with acute OPs poisoning before treatment and decreased after treatment. The present study also show that CBMN cyt assay parameters and 8-OHdG levels could be affected by some endocrine hormones such as E2, fT3, fT4, GH, IGF-1, FSH, LH, TSH, PRL, but not be related to ACTH and tT levels in acute OPs poisoning. In conclusion, it is believed that this is the first study to evaluate the chromosomal/oxidative DNA damage, cell proliferation, cell death and their associations with endocrine hormones in acute OPs poisoning. These preliminary findings need to be supported by further studies with larger sample sizes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180108
[Lr] Last revision date:180108
[St] Status:In-Data-Review

  10 / 2920 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29217407
[Au] Autor:Alahakoon C; Dassanayake TL; Gawarammana IB; Weerasinghe VS
[Ad] Address:Department of Physiology, University of Peradeniya, Peradeniya, 20400, Sri Lanka; South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, 20400, Sri Lanka. Electronic address: alahakoonchanika@gmail.com.
[Ti] Title:Can we predict intermediate syndrome? A review.
[So] Source:Neurotoxicology;, 2017 Dec 05.
[Is] ISSN:1872-9711
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Ingestion of organophosphorus insecticides (OPI) is a common method of deliberate self harm in the developing world. Deaths mainly follow as a result of the respiratory failure associated with both cholinergic crisis and the intermediate syndrome. Even though death can be prevented by early mechanical ventilation of these patients, limited studies are available regarding the prediction of intermediate syndrome and subsequent respiratory failure. OBJECTIVE: To systematically review articles that are published with regard to possible prediction of intermediate syndrome using clinical, biochemical and electrophysiological parameters. METHODS: A systematic review on literature published in English language was done in the PubMed database without a date limitation. Two sets of search terms were used. The first set consisted of MeSH Terms "organophosphates", "organophosphate poisoning", "op poisoning" "organophosphate insecticide poisoning" and "organophosphorus". The second set included the MeSH Terms "Intermediate syndrome", "proximal muscle weakness", "cranial nerve palsies", "respiratory depression" and "neck muscle weakness". Articles containing at least one word from each set were reviewed. RESULTS: At least one MeSH term from each set was incorporated in 179 articles. Of these, 69 were rejected as they were not related to organophosphate poisoning or intermediate syndrome. PREDICTION OF IMS: Clinical prediction is mostly based on ICU scoring systems. Biochemical markers such as reduced levels of serum and erythrocyte acetylcholine esterase have been studied many times. Both clinical and biochemical markers show a modest relationship in predicting IMS. Single fibre electromyography show promising results as it directly assesses neuromuscular junction. CONCLUSION: The intermediate syndrome which follows organophosphate poisoning still remains a significant problem with its high morbidity. Clinical and biochemical markers show modest results in predicting IMS. Neurophysiological markers such as single fibre EMG should be studied further as they measure activity of affected nicotinic receptors directly.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 171212
[Lr] Last revision date:171212
[St] Status:Publisher


page 1 of 292 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information