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[PMID]: 29221712
[Au] Autor:Bonura A; Di Blasi D; Barletta B; Butteroni C; Corinti S; Gervasi F; Melis MR; Uasuf C; Ragusa MA; Fabio C; Di Felice G; Colombo P
[Ad] Address:Istituto di Biomedicina ed Immunologia Molecolare "Alberto Monroy" del Consiglio Nazionale delle Ricerche, Palermo, Italy.
[Ti] Title:Modulating allergic response by engineering the major Parietaria allergens.
[So] Source:J Allergy Clin Immunol;141(3):1142-1144.e3, 2018 Mar.
[Is] ISSN:1097-6825
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

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[PMID]: 28831678
[Au] Autor:Arej N; Irani C; Abdelmassih Y; Slim E; Antoun J; Bejjani R; Schakal A; Waked N
[Ad] Address:Department of Ophthalmology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon. nicolas.arej@gmail.com.
[Ti] Title:Evaluation of allergic sensitization in Lebanese patients with allergic conjunctivitis.
[So] Source:Int Ophthalmol;, 2017 Aug 22.
[Is] ISSN:1573-2630
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:PURPOSE: To describe the profile of patients with allergic conjunctivitis (AC) regarding their demographics, symptomatology and specific allergen sensitization, in a Lebanese tertiary hospital. METHODS: Cross-sectional study conducted at the Hôtel-Dieu de France hospital (Beirut, Lebanon) during a period of 18 months. Patients with seasonal or perennial AC presenting for ophthalmic consultation had measurements of total and specific IgE. A matching group of patients with AC seen at the allergist office during the same period underwent skin prick tests (SPTs). RESULTS: Forty-four patients were enrolled for blood work by their ophthalmologists. Seasonal and perennial forms were almost equivalent. In total, 56.8% had positive specific IgE, with higher prevalence in patients with seasonal AC (p = 0.002), other associated allergies particularly allergic rhinitis (p = 0.002) or a family history of allergy (p = 0.005). Ocular surface severity scales were not shown as predictors. High levels of total IgE were commonly detected in those with positive specific IgE. Thirty-eight patients were assessed with SPT, and all had a positive result for at least one allergen. Dust mites were found to be the most frequent allergens based upon both specific IgE (72%) and SPT (92%), followed by Parietaria and other pollens. CONCLUSION: In our study, dust mites mono- or co-sensitization is present in the majority of patients with AC, with odds of positivity being higher using SPT than specific IgE. The latter are found more readily in seasonal AC and in the presence of personal and family history of allergy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170823
[Lr] Last revision date:170823
[St] Status:Publisher
[do] DOI:10.1007/s10792-017-0696-y

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[PMID]: 28417623
[Au] Autor:Ciprandi G; Comite P; Ferrero F; Mussap M
[Ad] Address:Allergy Department, Istituto di Ricovero e Cura a Carattere Scientifico - Azienda Ospedaliera-Universitaria (IRCCS-AOU), San Martino, Genoa, Italy.
[Ti] Title:A Real Life Comparison between Allergenic Extracts and Allergenic Molecules.
[So] Source:Iran J Allergy Asthma Immunol;16(1):39-44, 2017 Feb.
[Is] ISSN:1735-1502
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:Serum IgE assay is a mainstay step in the allergy work up. Allergenic extracts and molecular components are available at present. This real life study compared the serum specific IgE levels against allergenic extracts with allergenic molecules in patients allergic to Parietaria, Betulaceae, and mites. This retrospective real life study included 489 subjects with respiratory allergy. Inclusion criteria were 1) documented diagnosis of allergic rhinitis (AR) and/or allergic asthma, and 2) documented allergy to Parietaria judaica (Par j) 2 (216 patients: 112 females, mean age 42 years), or to Betula verrucosa (Bet v) 1 (62 patients: 35 females, mean age 3 years), or Dermatophagoides pteronyssinus (Der p) 1 (211 patients: 107 females, mean age 34 years); and mono-allergy. Serum IgE, specific both for total/crude allergen extracts and individual purified/recombinant allergens, were assessed by ImmunoCap system. The serum IgE levels to birch extract were very strongly (R2=0.96) related to IgE to Bet v 1. There was a strong (R2=0.71) correlation between Dermatophagoides pteronyssinus IgE and Der p 1. A very strong (R2=0.87) correlation also existed between Parietaria extract IgE and Par j 2 IgE levels. However, there was discrepancy between percentages of positivity between allergenic extracts and molecules. Therefore, allergen molecular diagnostics may represent a useful way in allergy work up, but deserves caution in particular circumstances.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170418
[Lr] Last revision date:170418
[St] Status:In-Data-Review

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[PMID]: 28270216
[Au] Autor:Miraglia Del Giudice M; Indolfi C; Capasso M; Maiello N; Decimo F; Ciprandi G
[Ad] Address:Department of Woman, Child and General and Specialized Surgery, Second University of Naples, Naples, Italy.
[Ti] Title:Bifidobacterium mixture (B longum BB536, B infantis M-63, B breve M-16V) treatment in children with seasonal allergic rhinitis and intermittent asthma.
[So] Source:Ital J Pediatr;43(1):25, 2017 Mar 07.
[Is] ISSN:1824-7288
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Allergic rhinitis (AR) and allergic asthma are caused by an IgE-mediated inflammatory reaction. Probiotics may exert anti-inflammatory and immune-modulatory activity. Thus, this study aimed at investigating whether a Bifidobacteria mixture could be able to relieve nasal symptoms, and affect quality of life (QoL) in children with AR and intermittent asthma due to Parietaria allergy. MATERIALS AND METHODS: The present study was conducted as placebo-controlled, double-blinded, and randomized. Globally, 40 children (18 males; mean age 9 ± 2.2 years) were enrolled. They were treated with probiotics or placebo: 1 sachet/day for 4 weeks. AR symptoms, and QoL were assessed at baseline and after treatment. Use of rescue medications, such as cetirizine syrup and salbutamol spray, was also permitted and recorded. RESULTS: Children treated with probiotic mixture achieved a significant improvement of symptoms (p < 0.005), and QoL ((p < 0.001). Placebo group had worsening of symptoms (p < 0.005) and QoL (p < 0.001). The use of rescue medications was overlapping in the two groups. The intergroup analysis showed that probiotic mixture was significantly superior than placebo for all parameters. CONCLUSIONS: The current study demonstrated that a Bifidobacteria mixture was able of significantly improving AR symptoms and QoL in children with pollen-induced AR and intermittent asthma. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov ID NCT02807064 .
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 170511
[Lr] Last revision date:170511
[St] Status:In-Process
[do] DOI:10.1186/s13052-017-0340-5

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[PMID]: 28120599
[Au] Autor:Ariano R; Cecchi L; Voltolini S; Quercia O; Scopano E; Ciprandi G; AAIITO Study group on Pollen Allergy
[Ad] Address:ASL n. 1 Imperia, Italy.
[Ti] Title: pollination duration: myth or fact?
[So] Source:Eur Ann Allergy Clin Immunol;49(1):6-10, 2017 Jan.
[Is] ISSN:1764-1489
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Even though the Parietaria pollen season may be rather long, it is commonly thought that Parietaria pollen is a perennial allergen present along the whole year. This study aimed at investigating the duration of Parietaria pollen season during a 10-year period in Italy, analysing also the annual pollen quantity and the differences among geographical areas. Pollen count was assessed daily for 10 years. Globally, ten Italian centers measured Parietaria pollen count. Start date, peak date, end date, duration (days), peak value, and seasonal pollen index were evaluated in each center. Ten-year Parietaria pollen count demonstrates that the pollen season usually lasted for 6-7 months in Italy. There are important differences among centres, mainly attributable to geoclimatic factors. This study demonstrates that Parietaria pollen season lasts about 6-7 months with two peaks (mainly in spring and lower in autumn) in Italy with important geographical variations. This information may have clinical relevance in managing patients allergic to Parietaria.
[Mh] MeSH terms primary: Parietaria/immunology
Pollination
[Mh] MeSH terms secundary: Humans
Retrospective Studies
Seasons
Time Factors
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170912
[Lr] Last revision date:170912
[Js] Journal subset:IM
[Da] Date of entry for processing:170126
[St] Status:MEDLINE

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[PMID]: 27980704
[Au] Autor:Gelardi M; Guglielmi AV; Iannuzzi L; Quaranta VN; Quaranta N; Landi M; Correale M; Sonnante A; Rossini M; Mariggiò MA; Canonica GW; Passalacqua G
[Ad] Address:Section of Otolaryngology, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari, Bari, Italy.
[Ti] Title:Local allergic rhinitis: entopy or spontaneous response?
[So] Source:World Allergy Organ J;9(1):39, 2016.
[Is] ISSN:1939-4551
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The existence of a local allergic rhintis was proposed on the basis of the detection of nasal IgE in the absence of a systemic sensitization. Nevertheless, the significance of this phenomenon remains still unclear. We assessed the presence of mucosal nasal IgE in patients with ascertained allergic rhinitis, nonallergic rhinitis with inflammation and in healthy controls. METHODS: Consecutive patients with a well ascertained diagnosis (clinical history, skin prick test, specific IgE assay, nasal endoscopy, nasal cytology) underwent an immunoenzymatic measurement of specific IgE to grass, cypress, parietaria and olive in nasal scrapings. RESULTS: Fifteen patients with allergic rhinitis, 12 with non allergic rhinitis and 14 healthy subjects were studied. The patients with allergic and nonallergic rhinitis had higher nasal symptoms as compared to control subjects. Systemic sensitizatition (assessed by skin test and CAP-RAST) was obviously more frequent in allergic rhinitis, than in the other two groups. Allergen-specific nasal IgE could be detected in all groups (86,7, 33,3, and 50 % positive, respectively), even more frequently in the control group than in nonallergic rhinitis patients. No difference among allergens was identified. Out of the 26 non-allergic patients (non allergic rhinitis + controls) nasal IgE were positive in 11(42 %). DISCUSSION: According to the results, the presence of nasal IgE against allergens seems to be a non-specific phenomenon, since they can be detected also in non allergic rhinitis and in healthy subjects. CONCLUSION: It can be hypothesized that the nasal IgE production represents a form of spontaneous immune response.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1612
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE

  7 / 568 MEDLINE  
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[PMID]: 27788883
[Au] Autor:Tiotiu A; Brazdova A; Longé C; Gallet P; Morisset M; Leduc V; Hilger C; Broussard C; Couderc R; Sutra JP; Sénéchal H; Poncet P
[Ad] Address:Pneumology-Allergology Department, University Hospital, Nancy, France.
[Ti] Title:Urtica dioica pollen allergy: Clinical, biological, and allergomics analysis.
[So] Source:Ann Allergy Asthma Immunol;117(5):527-534, 2016 Nov.
[Is] ISSN:1534-4436
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The most emblematic members of Urticaceae at allergic risk level are wall pellitories (Parietaria), whereas nettle (Urtica) pollen is considered as poorly allergenic. No allergen from nettle pollen has yet been characterized, whereas 4 are listed for Parietaria pollen by the International Union of Immunological Societies. Clinical and biological profiles of 2 adult men who developed symptoms against nettle pollen and/or leaves were studied. OBJECTIVE: To characterize the allergic reaction and identify the potential nettle pollen sensitizing allergens. METHODS: IgE-mediated reaction to nettle pollen extract was evaluated by skin prick test, immunoassay, nasal provocation, and basophil activation test. To characterize specific nettle pollen allergens, an allergomic (IgE immunoproteomic) analysis was performed combining 1- and 2-dimensional electrophoresis, IgE immunoblots of nettle pollen extract, identification of allergens by mass spectrometry, and database queries. RESULTS: The results of biological and immunochemical analyses revealed that the allergic rhinitis was due to Urtica dioica pollen in both patients. The allergomic analysis of nettle pollen extract allowed the characterization of 4 basic protein allergens: a thaumatin-like protein (osmotin) with a relative molecular mass of 27 to 29 kDa, a pectinesterase (relative molecular mass, 40 kDa), and 2 other basic proteins with relative molecular masses of 14 to 16 kDa and 43 kDa. There is no or only very weak allergen associations between pellitory and nettle pollen. CONCLUSION: Exposure to nettle pollen can be responsible of allergic symptoms, and several allergens were characterized. Unravelling the allergens of this underestimated allergy might help to improve diagnosis and care for patients, to predict cross-reactivities and design adapted specific immunotherapy.
[Mh] MeSH terms primary: Allergens/immunology
Conjunctivitis/immunology
Pollen/immunology
Rhinitis, Allergic, Seasonal/immunology
Urtica dioica/immunology
[Mh] MeSH terms secundary: Conjunctivitis/blood
Humans
Immunoglobulin E/immunology
Male
Middle Aged
Nasal Provocation Tests
Rhinitis, Allergic, Seasonal/blood
Skin Tests
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Entry month:1708
[Cu] Class update date: 170802
[Lr] Last revision date:170802
[Js] Journal subset:IM
[Da] Date of entry for processing:161030
[St] Status:MEDLINE

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[PMID]: 27619025
[Au] Autor:Katotomichelakis M; Danielides G; Iliou T; Anastassopoulos G; Nikolaidis C; Kirodymos E; Giotakis E; Constantinidis TC
[Ad] Address:Department of Otorhinolaryngology, Medical School, Democritus University of Thrace, Alexandroupolis, Evros, Greece. Electronic address: katotomihelakism@yahoo.gr.
[Ti] Title:Allergic sensitization prevalence in a children and adolescent population of northeastern Greece region.
[So] Source:Int J Pediatr Otorhinolaryngol;89:33-7, 2016 Oct.
[Is] ISSN:1872-8464
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To evaluate the prevalence of allergic sensitization in a childhood and adolescent population, to explore age- and gender-specific variations and finally to discover co-sensitivities among allergens. METHODS: A two-stage cross-sectional survey among school-aged children. The two stages of the study involved enrollment of schools and then skin prick testing (SPT) within schools. A total of 675 school children were included in the study. Of those, 231 were diagnosed with allergic rhinitis (AR), according to the medical history as provided by parental-completed questionnaires and positive SPT results. The antigen panel consisted of common allergens and more specifically house dust mites-HDM (Dermatophagoides farinae and Dermatophagoides pteronyssinus), grass mix, trees (olive, cypress and pine), weeds (Parietaria spp.), cat and dog epithelium and moulds (Alternaria spp., Cladosporium spp.). The SPT sensitivity was graded according to SPT-USA Standards. RESULTS: The overall prevalence rate of AR was 34.22%. In total, 93 school children (40.3%) were mono- and 138 (59.7%) were poly-sensitized. Overall, the most prevalent sensitizations in decreasing order were to HDM (59.74%), to grasses (48.9%), to Alternaria (34.6%) and to olive (14.71%). There were no age- and sex-specific differences, except for Alternaria mould that showed a significant prevalence among primary school-aged children and predominance in the female gender, by contrast to grass pollen allergy that was predominant to males. A 32% of SPT-positive individuals were not aware of their allergy, with no statistically significant differences between ages. Co-sensitivities were detected for grass pollens and pine and olive trees, for Alternaria and Cladosporium moulds, for cypress and pine trees, and finally for dog and cat danders. CONCLUSIONS: Given data among school-aged children should be a baseline from which to monitor disease trends and is considered important for the optimal management of AR patients.
[Mh] MeSH terms primary: Asthma/epidemiology
Rhinitis, Allergic/epidemiology
[Mh] MeSH terms secundary: Adolescent
Allergens/immunology
Alternaria/immunology
Animals
Cats
Child
Cladosporium/immunology
Comorbidity
Cross-Sectional Studies
Cupressus/immunology
Dogs
Female
Greece/epidemiology
Humans
Hypersensitivity/epidemiology
Hypersensitivity/immunology
Male
Olea/immunology
Parietaria/immunology
Pinus/immunology
Poaceae/immunology
Pollen/immunology
Prevalence
Pyroglyphidae/immunology
Rhinitis, Allergic/immunology
Skin Tests
Surveys and Questionnaires
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Allergens)
[Em] Entry month:1703
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:160914
[St] Status:MEDLINE

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[PMID]: 27425174
[Au] Autor:Liccardi G; Baldi G; Berra A; Ciccarelli A; Cutajar M; D'Amato M; D'Angelo R; Gargano D; Giannattasio D; Leone G; Lo Schiavo M; Madonna F; Montera C; Monti R; Parente R; Pedicini A; Pio A; Russo M; Salzillo A; Stanziola A; Vatrella A; Manzi F; Bilò MB; Italian Association of Hospital and Territorial Allergologists (AAIITO - Campania Region)
[Ad] Address:Department of Pulmonology, Haematology and Oncology, Division of Pulmonology and Allergology, High Speciality "A. Cardarelli" Hospital, Naples, Italy. Phone: +39 081 747 3335-4-3 Fax: + 39 081 747 3331 E-mail: gennaro.liccardi@tin.it.
[Ti] Title:Allergy in urban elderly population living in Campania region (Southern Italy). A multicenter study.
[So] Source:Eur Ann Allergy Clin Immunol;48(4):156-60, 2016 Jul.
[Is] ISSN:1764-1489
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Given the increasing life expectancy observed in Western countries, there is a marked interest to know more about how aging could influence respiratory health. The aim of our study was to assess the prevalence, clinical characteristics and age of onset of allergic sensitization and clinical symptoms in a sample of atopic elders living in Campania region area (Southern Italy). Fourteen Allergy units or Centres examined a total of 462 patients. In this context 215 (46.53%) had positive skin prick tests (SPTs) to at least one allergen and were diagnosed with respiratory allergy. Parietaria represents the most common sensitizing agent in elders living in Campania region, followed by dust mites, grass pollen and Olea europaea. A relatively high percentage of atopic subjects suffered from respiratory symptoms at a fairly advanced age, namely 8.3% at 60-64 years, 10.2% at 65-70 and 5.7% at > 70 years. In conclusion, the prevalence and clinical significance of airway allergic sensitization in the elderly living in Campania region is more significant than expected in latter stages of life. Physicians should not neglect the role of atopy as a risk factor for the onset of allergic respiratory symptoms even in elderly patients.
[Mh] MeSH terms primary: Respiratory Hypersensitivity/epidemiology
Urban Health
[Mh] MeSH terms secundary: Adult
Age Distribution
Age of Onset
Aged
Cross-Sectional Studies
Humans
Intradermal Tests
Italy/epidemiology
Middle Aged
Prevalence
Respiratory Hypersensitivity/diagnosis
Risk Factors
[Pt] Publication type:LETTER; MULTICENTER STUDY
[Em] Entry month:1701
[Cu] Class update date: 170117
[Lr] Last revision date:170117
[Js] Journal subset:IM
[Da] Date of entry for processing:160719
[St] Status:MEDLINE

  10 / 568 MEDLINE  
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[PMID]: 27349826
[Au] Autor:Bardei F; Bouziane H; Kadiri M; Rkiek B; Tebay A; Saoud A
[Ad] Address:Laboratoire écologie, biodiversité et environnement, faculté des sciences, université Abdelmalek Essaâdi, Mhannech II, BP 2121, Tétouan, Maroc. Electronic address: fadouasvt@hotmail.com.
[Ti] Title:Profils de sensibilisation cutanée aux allergènes respiratoires des patients de la ville de Tétouan (Nord Ouest du Maroc). [Skin sensitisation profiles to inhalant allergens for patients in Tétouan city (North West of Morocco)].
[So] Source:Rev Pneumol Clin;72(4):221-7, 2016 Aug.
[Is] ISSN:0761-8417
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:The prevalence of respiratory allergies is increasing and is a serious global health problem. The objective of the study was to determine the prevalence of skin sensitization to inhalant allergens in patients consulting for respiratory allergy, to identify the main allergens involved and to evaluate the profile of skin prick-test reactivity related to sex, age and season. This retrospective study included 379 patients consulting during 2009-2012 in three private medical offices of Tetouan. Of the 379 patients, 39.6% were monosensitized and 60.4% polysensitized. The percentages of polysensitized patients were higher in patients exhibiting rhinoconjunctivitis and astma-rhinoconjunctivitis than in subjects with asthma. The prevalence of symptoms according to sex showed no significant difference (P=0.64). Regarding age, a significant difference was observed in the case of rhinoconjunctivitis (P<0.01), while asthma and asthma-rhinoconjunctivitis showed no significant difference. Sensitization to house dust mites was the most frequent followed by grasses, olives and Parietaria. The multiple correspondence analyses (ACM) showed that patients under 20-years of age with asthma and asthma-rhinoconjunctivitis profile are more associated with sensitization to mites during the spring and autumn. The 20-49-year age group was represented mainly by polysensitized patients with rhinoconjunctivitis. Sensitization to mites ranks first in Tetouan followed by the percentage of sensitized patients to grass pollen and olive. The ACM showed that the house dust mite asthma seems to affect more children and adolescents while the 20-49 year age of polysensitized group suffers significantly rhinoconjunctivitis.
[Mh] MeSH terms primary: Allergens/immunology
Asthma/epidemiology
Dermatitis, Allergic Contact/epidemiology
Rhinitis, Allergic/epidemiology
[Mh] MeSH terms secundary: Adolescent
Adult
Animals
Asthma/complications
Asthma/immunology
Child
Dermatitis, Allergic Contact/etiology
Dermatitis, Allergic Contact/immunology
Female
Humans
Inhalation Exposure/statistics & numerical data
Male
Middle Aged
Morocco/epidemiology
Prevalence
Retrospective Studies
Rhinitis, Allergic/complications
Rhinitis, Allergic/etiology
Rhinitis, Allergic/immunology
Skin Tests
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Allergens)
[Em] Entry month:1705
[Cu] Class update date: 170501
[Lr] Last revision date:170501
[Js] Journal subset:IM
[Da] Date of entry for processing:160629
[St] Status:MEDLINE


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