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[PMID]: 29506510
[Au] Autor:Guo J; Tang W; Ye X; Wu H; Xu G; Liu W; Zhang Y
[Ad] Address:Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China.
[Ti] Title:Predictive multi-imaging biomarkers relevant for visual acuity in idiopathic macular telangiectasis type 1.
[So] Source:BMC Ophthalmol;18(1):69, 2018 Mar 05.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: To evaluate the structural changes associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities. METHODS: A retrospective study of 14 patients with MT type 1 and of 10 eyes from 10 healthy individuals as age-matched controls was conducted. The medical records of patients who had undergone colour fundus photography, spectral domain optical coherence tomography (OCT), fluorescein angiography and OCT angiography were reviewed. Central macular thickness (CMT), the areas of macular oedema and ellipsoid zone (EZ) disruption, EZ length, disorganization of the retinal inner layers (DRIL) and external limiting membrane (ELM) disruption, as measured by spectral domain OCT; and vascular density and the foveal avascular zones (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as measured by OCT angiography, were assessed in MT type 1 eyes and correlated with VA. RESULTS: The mean baseline best-corrected VA of MT type 1 eyes was 0.45 ± 0.28. The mean CMT was 385.19 ± 75.21 µm in MT type 1 eyes and 252.43 ± 15.77 µm in contralateral eyes (Z = - 4.113, p < 0.001). The mean vessel density of the DCP was lower in MT type 1 eyes (47.25 ± 4.69%) than in contralateral eyes (53.93 ± 2.94%) and normal eyes (59.37 ± 2.50%) (Z = - 3.492, - 4.099; p < 0.001, < 0.001). The baseline logMAR VA was correlated with CMT (r = 0.682, p = 0.007), SCP density (r = - 0.652, p = 0.012), DCP density (r = - 0.700, p = 0.005), total area of EZ disruption (r = 0.649, p = 0.012); and total lengths of EZ (r = 0.681, p = 0.007), ELM (r = 0.699, p = 0.005) and DRIL (r = 0.707, p = 0.005) disruption in the 1-mm-diameter foveal region in MT type 1 eyes. CONCLUSIONS: Decreased DCP density and the presence of DRIL may be predictive biomarkers of VA in MT type 1. CMT, SCP density, total area of EZ disruption, and lengths of EZ and ELM disruption within the 1-mm-diameter central region were strongly associated with VA.
[Mh] MeSH terms primary: Computed Tomography Angiography
Fluorescein Angiography
Retinal Telangiectasis/diagnostic imaging
Tomography, Optical Coherence
Visual Acuity/physiology
[Mh] MeSH terms secundary: Adult
Aged
Biomarkers
Female
Humans
Macular Edema/diagnostic imaging
Male
Middle Aged
Multimodal Imaging
Retinal Telangiectasis/physiopathology
Retinal Vessels/diagnostic imaging
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180307
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0737-y

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[PMID]: 29405040
[Au] Autor:Wahab A; Jan SA; Rauf A; Rehman ZU; Khan Z; Ahmed A; Syed F; Safi SZ; Khan H; Imran M
[Ad] Address:Department of Chemistry, Islamia College University, Peshawar-25120 KP, Pakistan.
[Ti] Title:Phytochemical composition, biological potential and enzyme inhibition activity of Scandix pecten-veneris L.
[So] Source:J Zhejiang Univ Sci B;19(2):120-129, 2018 Feb..
[Is] ISSN:1862-1783
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Scandix pecten-veneris L. is a less studied wild edible herb and is considered an extinct plant species in many parts of the world. This study was designed to evaluate its phytochemical composition and biological potential of S. pecten-veneris L. METHODS: Phytochemicals including alkaloids, flavonoids, polyphenols, and tannins were determined in extracts of S. pecten-veneris. Antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), while reducing power was tested by ferric reducing/antioxidant power (FRAP) assay. Antimicrobial activity against seven bacterial and four fungal strains was evaluated using agar well diffusion assay. Enzymes inhibition study was performed for urease, phosphodiesterase-I, and catalase-II. RESULTS: S. pecten-veneris showed moderate antiradical activity and reducing potential of hydroxyl radicals to about 20% of the initial value. The antioxidant activity of various extracts of S. pecten-veneris showed a linear correlation with total phenolic contents in the order of water>n-butanol>chloroform>ethyl acetate>methanol extracts. S. pecten-veneris leaves showed the highest inhibitory activity against Staphylococcus aureus while the highest antifungal activity was observed against Candida albicans. The plant extract was most potent against urease enzymes but showed moderate activity against phosphodiestrase-I and carbonic anhydrase-II. CONCLUSIONS: Our data demonstrate that in addition to its culinary uses, S. pecten-veneris has good medicinal potential and hence could be used for treating some specific health ailments.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1631/jzus.B1600443

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[PMID]: 29183023
[Au] Autor:Demirel S; Degirmenci MFK; Bilici S; Yanik Ö; Batioglu F; Özmert E; Alp N
[Ad] Address:Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.
[Ti] Title:The Recovery of Microvascular Status Evaluated by Optical Coherence Tomography Angiography in Patients after Successful Macular Hole Surgery.
[So] Source:Ophthalmic Res;59(1):53-57, 2018.
[Is] ISSN:1423-0259
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:PURPOSE: The aim of this study was to evaluate the optical coherence tomography angiography (OCTA) features of patients who underwent successful macular hole (MH) surgery. METHODS: Nineteen patients who underwent surgery in a single eye due to MH and 13 healthy subjects as a control group were included in the study. Vascular densities, flow indexes, and the foveal avascular zone (FAZ) area in superficial and deep retinal capillary plexuses were evaluated by OCTA in the right eyes of the control group, and both the surgical and healthy fellow eyes of the patients. RESULTS: The mean vascular densities of the superficial and deep capillary plexuses were significantly lower in the surgical eyes than in the control group (44.1 vs. 49.6%, p = 0.002, and 47.3 vs. 59.1%, p = 0.009, respectively). The mean superficial and deep capillary flow indexes were significantly lower in the surgical eyes than in the control group (0.85 vs. 1.35, p = 0.003, and 0.57 vs. 1.45, p = 0.001, respectively), while the mean superficial and deep FAZ area were significantly greater in the surgical eyes in comparison to the control group (0.55 vs. 0.32, p < 0.001, and 0.64 vs. 0.37, p = 0.001, respectively). There was no difference between the flow indexes of both layers of the healthy fellow eyes and the control group. CONCLUSIONS: These preliminary results may be an explanation for unsatisfactory visual gain after surgery, despite the successful anatomical closure of the MH.
[Mh] MeSH terms primary: Fovea Centralis/blood supply
Microvessels/diagnostic imaging
Retinal Perforations/pathology
Retinal Vessels/diagnostic imaging
[Mh] MeSH terms secundary: Aged
Case-Control Studies
Female
Fluorescein Angiography/methods
Fovea Centralis/diagnostic imaging
Humans
Macula Lutea/blood supply
Male
Middle Aged
Retinal Perforations/surgery
Retrospective Studies
Tomography, Optical Coherence/methods
Visual Acuity
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171129
[St] Status:MEDLINE
[do] DOI:10.1159/000484092

  4 / 12913 MEDLINE  
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[PMID]: 29403335
[Au] Autor:Wong SH; Turbin RE; Frohman LP
[Ad] Address:Institute of Ophthalmology & Visual Science, Rutgers New Jersey Medical School, Newark.
[Ti] Title:Takayasu arteritis-related photic and postprandial amaurosis.
[So] Source:Digit J Ophthalmol;23(4):13-14, 2017.
[Is] ISSN:1542-8958
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We report the case of a 66-year-old man with Takayasu arteritis who developed photic and postprandial amaurosis occurring at a corticosteroid dose <40 mg per day, despite concurrent methotrexate. The amaurosis resolved with correction of anemia by packed red blood cell transfusion. Marginal retinal perfusion in Takayasu arteritis may precipitate symptomatic hypoxia as a result of eating a meal or exposing the eye to bright lights. Correction of anemia improves oxygen delivery to the hypoxic retina and relieves recurrent amaurosis.
[Mh] MeSH terms primary: Blindness/etiology
Postprandial Period
Takayasu Arteritis/complications
[Mh] MeSH terms secundary: Aged
Axillary Artery/diagnostic imaging
Blindness/diagnosis
Blindness/physiopathology
Diagnosis, Differential
Fluorescein Angiography/methods
Fundus Oculi
Humans
Magnetic Resonance Angiography
Male
Retinal Vessels/diagnostic imaging
Subclavian Artery/diagnostic imaging
Takayasu Arteritis/diagnosis
Visual Acuity
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:180207
[St] Status:MEDLINE
[do] DOI:10.5693/djo.02.2017.09.002

  5 / 12913 MEDLINE  
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[PMID]: 28457994
[Au] Autor:Kady N; Yan Y; Salazar T; Wang Q; Chakravarthy H; Huang C; Beli E; Navitskaya S; Grant M; Busik J
[Ad] Address:Department of Physiology, Michigan State University, East Lansing, MI, USA.
[Ti] Title:Increase in acid sphingomyelinase level in human retinal endothelial cells and CD34 circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes.
[So] Source:J Clin Lipidol;11(3):694-703, 2017 May - Jun.
[Is] ISSN:1933-2874
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Diabetic retinopathy is a microvascular disease that results from retinal vascular degeneration and defective repair due to diabetes-induced endothelial progenitor dysfunction. OBJECTIVE: Understanding key molecular factors involved in vascular degeneration and repair is paramount for developing effective diabetic retinopathy treatment strategies. We propose that diabetes-induced activation of acid sphingomyelinase (ASM) plays essential role in retinal endothelial and CD34 circulating angiogenic cell (CAC) dysfunction in diabetes. METHODS: Human retinal endothelial cells (HRECs) isolated from control and diabetic donor tissue and human CD34 CACs from control and diabetic patients were used in this study. ASM messenger RNA and protein expression were assessed by quantitative polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. To evaluate the effect of diabetes-induced ASM on HRECs and CD34 CACs function, tube formation, CAC incorporation into endothelial tubes, and diurnal release of CD34 CACs in diabetic individuals were determined. RESULTS: ASM expression level was significantly increased in HRECs isolated from diabetic compared with control donor tissue, as well as CD34 CACs and plasma of diabetic patients. A significant decrease in tube area was observed in HRECs from diabetic donors compared with control HRECs. The tube formation deficiency was associated with increased expression of ASM in diabetic HRECs. Moreover, diabetic CD34 CACs with high ASM showed defective incorporation into endothelial tubes. Diurnal release of CD34 CACs was disrupted with the rhythmicity lost in diabetic patients. CONCLUSION: Collectively, these findings support that diabetes-induced ASM upregulation has a marked detrimental effect on both retinal endothelial cells and CACs.
[Mh] MeSH terms primary: Diabetic Retinopathy/enzymology
Endothelial Cells/metabolism
Neovascularization, Pathologic/pathology
Retina/pathology
Retinal Vessels/physiopathology
Sphingomyelin Phosphodiesterase/metabolism
[Mh] MeSH terms secundary: Aged
Antigens, CD34/metabolism
Circadian Rhythm
Diabetic Retinopathy/blood
Diabetic Retinopathy/pathology
Diabetic Retinopathy/physiopathology
Endothelial Cells/pathology
Female
Gene Expression Regulation, Enzymologic
Humans
Male
Middle Aged
Retinal Vessels/metabolism
Sphingomyelin Phosphodiesterase/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antigens, CD34); EC 3.1.4.- (acid sphingomyelinase-1); EC 3.1.4.12 (Sphingomyelin Phosphodiesterase)
[Em] Entry month:1712
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:170502
[St] Status:MEDLINE

  6 / 12913 MEDLINE  
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[PMID]: 29351793
[Au] Autor:Jiang Y; Brenner JE; Foster WJ
[Ad] Address:Department of Ophthalmology, Temple University, 3401 N Broad Street, 6th Floor Parkinson Pavilion, Philadelphia, PA, 19140, USA.
[Ti] Title:Retinal complications of gout: a case report and review of the literature.
[So] Source:BMC Ophthalmol;18(1):11, 2018 Jan 19.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: There have been few reported findings of posterior segment complications of gout. While exudative lesions, an increased risk of macular degeneration, and vascular occlusions have been previously reported, to our knowledge, refractile macular lesions have not been reported in a patient with chronic uncontrolled gout. CASE PRESENTATION: Highly refractile, crystal-like lesions were found in the macula of a 62 year old male patient with chronically uncontrolled gout. The lesions appeared at the termination of retinal arterioles and were located at the level of the retinal pigment epithelium. The lesions did not stain with fluorescein and were associated with larger areas geographic atrophy. Review of the patient's blood tests revealed well-controlled vasculopathic risk factors. Fundus appearance and best-corrected visual acuity remained stable over 12 months of follow-up during which the uric acid levels were well controlled. CONCLUSION: Retinopathy may be associated with chronically uncontrolled gout and patients with visual complaints should undergo a dilated examination in addition to the typical anterior segment slit-lamp exam.
[Mh] MeSH terms primary: Anterior Eye Segment/diagnostic imaging
Gout/complications
Macula Lutea/diagnostic imaging
Retinal Diseases/etiology
Retinal Vessels/diagnostic imaging
[Mh] MeSH terms secundary: Fluorescein Angiography/methods
Fundus Oculi
Gout/blood
Humans
Male
Middle Aged
Retinal Diseases/diagnosis
Tomography, Optical Coherence/methods
Uric Acid/blood
Visual Acuity
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:268B43MJ25 (Uric Acid)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:180121
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0669-6

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[PMID]: 28744554
[Au] Autor:Wei Y; Jiang H; Shi Y; Qu D; Gregori G; Zheng F; Rundek T; Wang J
[Ad] Address:Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
[Ti] Title:Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3804-3817, 2017 07 01.
[Is] ISSN:1552-5783
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Purpose: To characterize age-related alterations in the retinal microcirculation, microvascular network, and microstructure in healthy subjects. Methods: Seventy-four healthy subjects aged from 18 to 82 years were recruited and divided into four age groups (G1 with age <35 years, G2 with age 35 ∼ 49 years, G3 with age 50 ∼ 64 years, and G4 with age ≥65 years). Custom ultra-high resolution optical coherence tomography (UHR-OCT) was used to acquire six intraretinal layers of the macula. OCT angiography (OCTA) was used to image the retinal microvascular network. The retinal blood flow velocity (BFV) was measured using a Retinal Function Imager (RFI). Results: Compared to G1, G2 had significant thinning of the retinal nerve fiber layer (RNFL) (P < 0.05), while G3 had thinning of the RNFL and ganglion cell and inner plexiform layer (GCIPL) (P < 0.05), in addition to thickening of the outer plexiform layer (OPL) and photoreceptor layer (PR) (P < 0.05). G4 had loss in retinal vessel density, thinning in RNFL and GCIPL, and decrease in venular BFV, in addition to thickening of the OPL and PR (P < 0.05). Age was negatively related to retinal vessel densities, the inner retinal layers, and venular BFV (P < 0.05). By contrast, age was positively related to OPL and PR (P < 0.05). Conclusions: During aging, decreases in retinal vessel density, inner retinal layer thickness, and venular BFV were evident and impacted each other as observed by simultaneous changes in multiple retinal components.
[Mh] MeSH terms primary: Aging/physiology
Blood Flow Velocity/physiology
Capillaries/physiology
Microcirculation/physiology
Retinal Vessels/physiology
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Capillaries/anatomy & histology
Computed Tomography Angiography
Female
Fractals
Healthy Volunteers
Humans
Male
Middle Aged
Nerve Fibers/physiology
Retinal Ganglion Cells/cytology
Retinal Ganglion Cells/physiology
Retinal Vessels/anatomy & histology
Tomography, Optical Coherence
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1708
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[Js] Journal subset:IM
[Da] Date of entry for processing:170727
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21460

  8 / 12913 MEDLINE  
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[PMID]: 28469098
[Au] Autor:Fang XJ; Yu M; Wu Y; Zhang ZH; Wang WW; Wang ZX; Yuan Y
[Ad] Address:Department of Neurology, Peking University First Hospital, Beijing 100034, China.
[Ti] Title:Study of Enhanced Depth Imaging Optical Coherence Tomography in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.
[So] Source:Chin Med J (Engl);130(9):1042-1048, 2017 May 05.
[Is] ISSN:0366-6999
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small artery disease caused by NOTCH3 gene mutation. We performed enhanced depth imaging optical coherence tomography (EDI-OCT) to evaluate the retinal vessel changes in CADASIL patients and assessed their consonance with brain magnetic resonance imaging (MRI) findings. METHODS: Of 27 genetically confirmed patients and an equal number of controls were recruited at the Peking University First Hospital from January 2015 to August 2016. All patients underwent 7T-MRI of the brain. Fazekas score, number of small infarcts and microbleeds were evaluated. All patients and controls underwent EDI-OCT to measure subfoveal choroidal thickness (SFCT), inner and outer diameters as well as arterial and venous wall thickness, and arterial venous ratio of the inner (AVRin) and outer diameters (AVRout). The relation between retinal vessel changes and Fazekas scores, numbers of small infarcts, or microbleeds was analyzed. Paired t-test was used to compare the SFCT and retinal vessel measurement data between patients and controls. Spearman's correlation was used to investigate the correlation between retinal vessel changes and MRI lesions. RESULTS: In CADASIL patients, mean SFCT (268.37 ± 46.50 µm) and mean arterial inner diameter (93.46 ± 9.70 µm) were significantly lower than that in controls (P < 0.001,P = 0.048, respectively). Mean arterial outer diameter (131.74 ± 10.87 µm), venous inner (128.99 ± 13.62 µm) and outer diameter (164.82 ± 14.77 µm), and mean arterial (19.13 ± 1.85 µm) and venous (17.91 ± 2.76 µm) wall thickness were significantly higher than that in controls (P = 0.023,P = 0.004,P < 0.001,P < 0.001, respectively). Arterial inner diameter (rs= -0.39, P= 0.044), AVRin (rs= -0.65,P < 0.001), and AVRout (rs= -0.56, P= 0.002) showed a negative correlation with the number of small infarcts. Venous inner diameter (rs = 0.46, P= 0.016) showed a positive correlation with the number of small infarcts. Venous inner diameter (rs = 0.59, P= 0.002), outer diameter (rs = 0.47, P= 0.017), showed a positive correlation with the number of cerebral microbleeds (CMBs). AVRin (rs= -0.52, P= 0.007) and AVRout (rs= -0.40, P= 0.048) showed a negative correlation with the number of CMBs. CONCLUSIONS: Measurement of retinal vessels using EDI-OCT correlates moderately well with MRI parameters. EDI-OCT might be a useful evaluation tool for CADASIL patients.
[Mh] MeSH terms primary: Leukoencephalopathies/pathology
Magnetic Resonance Imaging/methods
Tomography, Optical Coherence/methods
[Mh] MeSH terms secundary: Adult
Brain/metabolism
CADASIL
Cerebral Infarction/pathology
Female
Humans
Male
Middle Aged
Mutation
Receptor, Notch3/genetics
Retinal Vessels/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Receptor, Notch3)
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.204935

  9 / 12913 MEDLINE  
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[PMID]: 29288664
[Au] Autor:Wu J; Wang R; Yang D; Tang W; Chen Z; Sun Q; Liu L; Zang R
[Ad] Address:Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
[Ti] Title:Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway.
[So] Source:Biochem Biophys Res Commun;495(4):2462-2468, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Retinal ischemia/reperfusion injury (IRI) plays a crucial role in the pathophysiology of various ocular diseases. Our previous study have shown that postconditioning with inhaled hydrogen (H ) (HPC) can protect retinal ganglion cells (RGCs) in a rat model of retinal IRI. Our further study aims to investigate potential mechanisms underlying HPC-induced protection. Retinal IRI was performed on the right eyes of rats and was followed by inhalation of 67% H mixed with 33% oxygen immediately after ischemia for 1 h daily for one week. RGC density was counted using haematoxylin and eosin (HE) staining, retrograde labelling with cholera toxin beta (CTB) and TUNEL staining, respectively. Visual function was assessed using flash visual evoked potentials (FVEP) and pupillary light reflex (PLR). The phosphorylated Akt was analysed by RT-PCR and western blot. The results showed that administration of HPC significantly inhibited the apoptosis of RGCs and protected the visual function. Simultaneously, HPC treatment markedly increased the phosphorylations of Akt. Blockade of PI3K activity by inhibitors (LY294002) dramatically abolished its anti-apoptotic effect and lowered both visual function and Akt phosphorylation levels. Taken together, our results demonstrate that HPC appears to confer neuroprotection against retinal IRI via the PI3K/Akt pathway.
[Mh] MeSH terms primary: Hydrogen/administration & dosage
Phosphatidylinositol 3-Kinases/metabolism
Proto-Oncogene Proteins c-akt/metabolism
Reperfusion Injury/drug therapy
Reperfusion Injury/metabolism
Retinal Ganglion Cells/metabolism
Retinal Vessels/drug effects
[Mh] MeSH terms secundary: Administration, Inhalation
Animals
Cell Survival
Male
Rats, Sprague-Dawley
Reperfusion Injury/pathology
Retinal Ganglion Cells/drug effects
Retinal Ganglion Cells/pathology
Retinal Vessels/pathology
Signal Transduction/drug effects
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:7YNJ3PO35Z (Hydrogen); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[Js] Journal subset:IM
[Da] Date of entry for processing:171231
[St] Status:MEDLINE

  10 / 12913 MEDLINE  
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[PMID]: 29443780
[Au] Autor:Lyu S; Zhang M; Wang RK; Gao Y; Zhang Q; Min X
[Ad] Address:Department of Ophthalmology, West China Hospital of Sichuan University, Wuhou District, Chengdu, Sichuan, China.
[Ti] Title:Analysis of the characteristics of optical coherence tomography angiography for retinal cavernous hemangioma: A case report.
[So] Source:Medicine (Baltimore);97(7):e9940, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Retinal cavernous hemangioma is a rare congenital vascular malformation with typical fundus changes. Optical coherence tomography angiography (OCTA), which is in rise in the recent years, is a rapid and noninvasive technology to assist in obtaining information regarding the blood flow changes in the fundus lesions from different layers without injecting a contrast agent. PATIENT CONCERNS: A 40-year-old male patient with visual occlusion in the right eye for >1 month was reported. DIAGNOSES: Retinal cavernous hemangioma was diagnosed by fundus examination, fluorescein angiography (FA) and OCTA, and the characteristics of OCTA images were analyzed. INTERVENTIONS: The lesion occurred outside the macula, the central vision remained basically normal, and no significant complications were noted in this patient. Therefore, we preferred to regularly follow-up without therapeutic intervention. CONCLUSIONS: OCTA can display fundus blood flow and vascular lesions noninvasively and rapidly. On OCTA, retinal cavernous hemangiomas showed characteristic changes and have good correspondence with fundus imaging and FA examinations. Moreover, OCTA remains more sensitive to vascular abnormalities, and imaging remains clearer, providing new diagnosis and follow-up route for this disease.
[Mh] MeSH terms primary: Fluorescein Angiography
Hemangioma, Cavernous/diagnostic imaging
Retinal Neoplasms/diagnostic imaging
Retinal Vessels/diagnostic imaging
Tomography, Optical Coherence
[Mh] MeSH terms secundary: Adult
Humans
Male
Regional Blood Flow
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009940


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