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[PMID]: 29313696
[Au] Autor:Mascagni P; Melandro F; Larghi Laureiro Z; Mennini G; Rossi M
[Ad] Address:Dipartimento di Chirurgia Generale e Specialistica, Azienda Ospedaliera Policlinico Umberto I, Italia.
[Ti] Title:Spontaneous hepatic rupture in a bodybuilder: a case report and review of the literature.
[So] Source:Rev Esp Enferm Dig;110, 2018 Jan 09.
[Is] ISSN:1130-0108
[Cp] Country of publication:Spain
[La] Language:eng
[Ab] Abstract:This article is the first description of a spontaneous hepatic rupture in a young bodybuilder with a history of clenbuterol and ephedrine alkaloid use. The patient presented with a sudden mid-epigastric pain and vomiting. Hemoglobin levels decreased a few hours later and a computed tomography scan was performed which revealed a rupture of the right liver capsule and hemoperitoneum. Two attempts at transarterial embolization did not control the bleeding and a right hemihepatectomy was performed. The pathological report identified a hepatic adenoma, a capsular tear and diffuse peliosis hepatis. The patient was discharged in a good condition after eleven days. Spontaneous hepatic ruptures are rare and life-threatening and are usually described in association with tumors, connective tissue diseases and gestosis. This article is a review of the available literature with regard to this condition, with a focus on its relation to peliosis hepatis and banned substance used by body image fanatics. The present case highlights the challenging diagnosis of this potentially fatal liver complication in a healthy appearing male, the risk associated with the online trade of performance enhancing drugs and its relation with peliosis hepatis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180109
[Lr] Last revision date:180109
[St] Status:Publisher
[do] DOI:10.17235/reed.2017.5103/2017

  2 / 514 MEDLINE  
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[PMID]: 29118875
[Au] Autor:Biswas S; Gogna S; Patel P
[Ad] Address:Department of Trauma and Acute Care Surgery, Forbes Hospital, Allegheny Health Network, PA 15146, USA.
[Ti] Title:A Fatal Case of Intra-Abdominal Hemorrhage Following Diagnostic Blind Percutaneous Liver Biopsy in a Patient With Peliosis Hepatis.
[So] Source:Gastroenterology Res;10(5):318-321, 2017 Oct.
[Is] ISSN:1918-2805
[Cp] Country of publication:Canada
[La] Language:eng
[Ab] Abstract:Peliosis hepatis (PH) is a rare vascular condition of the liver characterized by the presence of cystic blood filled cavities distributed randomly throughout the liver parenchyma. We describe a case of a 42-year-old previously healthy male patient, airlifted to us in a state of hemorrhagic shock after undergoing percutaneous diagnostic liver biopsy for lesions seen on CT scan. Repeat CT scan with IV contrast on presentation in our hospital showed intraperitoneal bleeding. Hepatic angiography failed to identify any specific bleeding source. A diagnostic laparoscopy was performed and approximate 9 L of hemoperitoneum was evacuated. The postoperative course was complicated with rapid hemodynamic deterioration, associated with acute hepatic failure progressively leading to multiorgan failure and death in spite of aggressive intensive care support. We suggest that PH should be considered as differential diagnosis of hypervascular hepatic lesions. It potentially can cause fatal acute non-traumatic liver hemorrhage.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171112
[Lr] Last revision date:171112
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.14740/gr873e

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[PMID]: 28990003
[Au] Autor:Tan CHN; Soon GST; Kow WCA
[Ad] Address:Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore.
[Ti] Title:Liver lesions detected in a hepatitis B core total antibody-positive patient masquerading as hepatocellular carcinoma: a rare case of peliosis hepatis and a review of the literature.
[So] Source:Ann Hepatobiliary Pancreat Surg;21(3):157-162, 2017 Aug.
[Is] ISSN:2508-5778
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Peliosis Hepatis (PH) is a rare vascular disorder of the liver, characterized by the presence of cystic blood-filled cavities distributed throughout the hepatic parenchyma. The pathogenesis of PH remains controversial. The preoperative diagnosis of PH is difficult, due to the non-specific imaging characteristics of PH and almost all cases are diagnosed on histology post resection. This study presents a case of PH masquerading as hepatocellular carcinoma (HCC). The patient is a 45-year old Chinese lady, who presented with transaminitis. She was found to be hepatitis B virus core total antibody-positive with an alpha-fetoprotein (AFP) of 29.4 ng/ml. Triphasic liver computed tomography showed several arterial hypervascular lesions and hypoenhancing lesions on the venous phase, particularly in the segments 6/7. Subsequently, a magnetic resonance imaging scan showed multiple lesions in the right hemiliver with an indeterminate enhancement patterns. Subsequently, she decided to undergo a resection procedure. Histopathology revealed findings consistent with PH with some unusual features. This case demonstrates a clinical conundrum, in which PH presented with a raised AFP, in a patient with risk factors for the development of HCC. The clinical suspicion of PH should be high in patients, who present with multiple hepatic lesions with variable enhancement patterns.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171013
[Lr] Last revision date:171013
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.14701/ahbps.2017.21.3.157

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[PMID]: 28721347
[Au] Autor:Butt MO; Luck NH; Hassan SM; Abbas Z; Mubarak M
[Ad] Address:Departments of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi - 74200, Pakistan.
[Ti] Title:Peliosis Hepatis Complicating Pregnancy: A Rare Entity.
[So] Source:J Transl Int Med;5(2):132-134, 2017 Jun.
[Is] ISSN:2450-131X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Peliosis hepatis (PH) is a rare, benign condition of the liver characterized by the presence of blood-filled lacunar spaces in the parenchyma. It usually has a chronic presentation and is a rare cause of portal hypertension reported in adult patients. Its etiology is diverse and ranges from infectious agents to tumors to toxic substances and anabolic steroids; however, the cause remains unclear in 25-50% of patients. Similarly, the symptomatology and imaging findings are diverse. Biopsy is the definitive test to diagnose the condition. Herein, we present a case of a young female presenting in her seventh month of gestational amenorrhea with signs of portal hypertension and subsequently diagnosed to have PH. She was managed conservatively and delivered her baby normally. Later, she presented with spontaneous bacterial peritonitis and hepatic encephalopathy and developed hepatorenal syndrome. She later succumbed to her illness. The condition should be kept in the differential diagnosis of the atypical liver masses and liver diseases causing portal hypertension.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170723
[Lr] Last revision date:170723
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1515/jtim-2017-0023

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[PMID]: 28430541
[Au] Autor:Elsayes KM; Shaaban AM; Rothan SM; Javadi S; Madrazo BL; Castillo RP; Casillas VJ; Menias CO
[Ad] Address:From the Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030 (K.M.E., S.J.); Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (A.M.S.); Department of Diagnostic and Interventional Imaging, McGove
[Ti] Title:A Comprehensive Approach to Hepatic Vascular Disease.
[So] Source:Radiographics;37(3):813-836, 2017 May-Jun.
[Is] ISSN:1527-1323
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The liver has a complex vascular supply, which involves the inflow of oxygenated blood through the hepatic artery (systemic circulation) and deoxygenated blood through the portal vein (portal circulation), as well as the outflow of deoxygenated blood through the hepatic veins to the inferior vena cava. A spectrum of vascular variants can involve the liver. Some of these variants may result in areas of enhancement that can mimic more serious pathologic conditions. In this article, the authors discuss a spectrum of variants and pathologic conditions that may involve the liver vasculature. These include variants, anomalies, and diseases involving the portal vein, such as rudimentary portal vein, thrombosis, cavernous transformation, thrombotic angiitis, thrombophlebitis, transient hepatic attenuation difference or transient hepatic intensity difference, portal venous aneurysm, and portal vein gas. The hepatic artery can be involved by various diseases, including thrombosis, stenosis, and aneurysm or pseudoaneurysm. Unusual "third inflow" sources of venous inflow are also discussed, including aberrant right gastric vein, aberrant left gastric vein, epigastric-paraumbilical veins, and cholecystic vein. A spectrum of variants and diseases involving the inferior vena cava and hepatic veins, including thrombosis, Budd-Chiari syndrome, veno-occlusive disease, stenosis, torsion, congestive hepatopathy, and peliosis hepatis, are discussed. Vascular shunts are illustrated, including portosystemic shunts (intra- and extrahepatic), arterioportal shunt, shunts of hereditary hemorrhagic telangiectasia, and acquired arteriovenous fistula. Familiarity with the pathogenesis and imaging features of these vascular entities can aid radiologic diagnoses and guide appropriate patient management. RSNA, 2017.
[Mh] MeSH terms primary: Hepatic Artery/diagnostic imaging
Hepatic Artery/pathology
Liver Diseases/diagnostic imaging
Liver Diseases/pathology
Liver/blood supply
Portal System/diagnostic imaging
Portal System/pathology
[Mh] MeSH terms secundary: Humans
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 171113
[Lr] Last revision date:171113
[Js] Journal subset:IM
[Da] Date of entry for processing:170422
[St] Status:MEDLINE
[do] DOI:10.1148/rg.2017160161

  6 / 514 MEDLINE  
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[PMID]: 28379599
[Au] Autor:Solimini R; Rotolo MC; Mastrobattista L; Mortali C; Minutillo A; Pichini S; Pacifici R; Palmi I
[Ad] Address:Department of Therapeutic Research and Medicines Evaluation, Drug Abuse and Doping Unit, Istituto Superiore di Sanità, Rome, Italy. renata.solimini@iss.it.
[Ti] Title:Hepatotoxicity associated with illicit use of anabolic androgenic steroids in doping.
[So] Source:Eur Rev Med Pharmacol Sci;21(1 Suppl):7-16, 2017 Mar.
[Is] ISSN:2284-0729
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Anabolic Androgenic Steroids (AAS) abuse and misuse is nowadays a harmful habit involving both professional or recreational athletes, as well as general population. AAS are also frequently present in over-the-counter dietary supplements without being declared in the list of ingredients, leaving consumers unaware of the risks of adverse effects. Indeed, health risks of AAS consumption in pharmaceutical preparations or dietary complements seem still underestimated and under-reported. The variety of complications due to AAS misuse involves cardiovascular, central nervous, musculoskeletal and genitourinary systems of both males and females; psychiatric and behavioral effects, damages to metabolic system, skin and mainly liver. For instance, relevant concern has been raised by the AAS hepatotoxicity including adenoma, hepatocellular carcinoma, cholestasis, and peliosis hepatis. The present review reports the information available on the hepatotoxic effects of AAS use in professional and amateur athletes.
[Mh] MeSH terms primary: Anabolic Agents/adverse effects
Carcinoma, Hepatocellular/chemically induced
Chemical and Drug Induced Liver Injury
Doping in Sports
[Mh] MeSH terms secundary: Athletes
Humans
Liver Neoplasms
Steroids
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Anabolic Agents); 0 (Steroids)
[Em] Entry month:1707
[Cu] Class update date: 170726
[Lr] Last revision date:170726
[Js] Journal subset:IM
[Da] Date of entry for processing:170406
[St] Status:MEDLINE

  7 / 514 MEDLINE  
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[PMID]: 28353584
[Au] Autor:Dai YN; Ren ZZ; Song WY; Huang HJ; Yang DH; Wang MS; Huang YC; Chen MJ; Zhang JJ; Tong YX; Pan HY
[Ad] Address:aDepartment of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College bDepartment of Infectious Diseases, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, China.
[Ti] Title:Peliosis hepatis: 2 case reports of a rare liver disorder and its differential diagnosis.
[So] Source:Medicine (Baltimore);96(13):e6471, 2017 Mar.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Peliosis hepatis (PH) is a rare tumor-like liver lesion composed of multiple blood-filled cavities within the liver parenchyma. It is hard to differentiate PH from other liver lesions by imaging, such as carcinoma, metastases, or abscess. PATIENT CONCERNS: Here, we reported 2 cases that presented with liver lesions under ultrasound and computed tomography (CT) scanning, without any history of liver diseases or drug usage traced back. DIAGNOSES: Liver biopsy and laparoscopy were processed, and the lesions were eventually diagnosed as PH by histopathology, which microscopically presented with multiple sinusoidal dilatations with blood-filled cystic spaces. INTERVENTIONS: After the liver biopsy or laparoscopy, the patients were discharged and followed up in the clinic. OUTCOMES: Both patients were followed up for at least 1 year with good recovery. LESSONS: PH should always be recognized in the differentiation of liver lesions, particularly indistinctive lesion(s) without any history of liver-related diseases.
[Mh] MeSH terms primary: Peliosis Hepatis/diagnostic imaging
[Mh] MeSH terms secundary: Diagnosis, Differential
Female
Humans
Liver/pathology
Male
Middle Aged
Peliosis Hepatis/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170413
[Lr] Last revision date:170413
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170330
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006471

  8 / 514 MEDLINE  
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[PMID]: 28180205
[Au] Autor:Loizides A; Glodny B; Zoller H; Zelger BG; Junker D; Henninger B; Putzer D; Gruber H
[Ad] Address:Department of Radiology, Medical University Innsbruck, Innsbruck, Austria. alexander.loizides@i-med.ac.at.
[Ti] Title:Contrast enhanced ultrasound of a rare case of Peliosis hepatis.
[So] Source:Med Ultrason;19(1):114-116, 2017 Jan 31.
[Is] ISSN:2066-8643
[Cp] Country of publication:Romania
[La] Language:eng
[Ab] Abstract:Peliosis hepatis is a rare benign disorder of the liver, histologically characterized by blood-filled cystic cavities of various sizes and irregular shapes, communicating with the hepatic sinusoids. Only a few cases of peliosis hepatis have been described using contrast enhanced ultrasound showing admittedly various dynamic enhancement patterns. We present a case of peliosis hepatis with a typical target-sign enhancement depicted by means of contrast enhanced ultrasound.
[Mh] MeSH terms primary: Contrast Media
Image Enhancement/methods
Peliosis Hepatis/diagnostic imaging
Ultrasonography, Interventional/methods
[Mh] MeSH terms secundary: Aged
Biopsy
Diagnosis, Differential
Female
Humans
Liver/blood supply
Liver/diagnostic imaging
Liver/pathology
Magnetic Resonance Imaging
Peliosis Hepatis/pathology
[Pt] Publication type:CASE REPORTS
[Nm] Name of substance:0 (Contrast Media)
[Em] Entry month:1709
[Cu] Class update date: 170913
[Lr] Last revision date:170913
[Js] Journal subset:IM
[Da] Date of entry for processing:170210
[St] Status:MEDLINE
[do] DOI:10.11152/mu-940

  9 / 514 MEDLINE  
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[PMID]: 27783341
[Au] Autor:Iwata T; Adachi K; Takahashi M
[Ad] Address:Department of Gastroenterology, Ebara Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tokyo, Japan.
[Ti] Title:Peliosis Hepatis Mimicking Malignant Hypervascular Tumors.
[So] Source:J Gastrointest Surg;21(6):1095-1098, 2017 Jun.
[Is] ISSN:1873-4626
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Peliosis hepatis is an uncommon vascular condition characterized by multiple, randomly distributed, blood-filled, and cyst-like cavities throughout the liver. The unique clinical nature consisting of an asymptomatic, benign, and incidental finding sometimes conceals itself even until autopsy. However, the exact pathomechanism remains as yet unproven. METHOD: We encountered the patient with multiple hypervascular masses in the whole liver and investigated the clinicopathological features underlying this condition. RESULTS: Detailed herein is a case of peliosis hepatis on the basis of our findings. Our patient illustrated a lethal instance which mimicked a malignancy although it is usually an indolent finding. CONCLUSION: Peliosis hepatis should always be borne in mind as a differential diagnosis of atypical hypervascular hepatic lesion, especially in patients with clinical conditions described in the text.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 171104
[Lr] Last revision date:171104
[St] Status:In-Process
[do] DOI:10.1007/s11605-016-3298-5

  10 / 514 MEDLINE  
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[PMID]: 27599419
[Au] Autor:Tsukamoto Y; Kiyasu J; Utsunomiya H; Nakashima Y; Choi I; Suehiro Y; Aratake Y; Abe Y
[Ad] Address:Department of Hematology, National Kyushu Cancer Center, National Hospital Organization.
[Ti] Title:Danazol-induced peliosis hepatis accompanied by disseminated intravascular coagulation in a patient with myelodysplastic syndrome transformed from aplastic anemia.
[So] Source:Rinsho Ketsueki;57(8):1026-31, 2016 08.
[Is] ISSN:0485-1439
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:Peliosis hepatis (PH) is a condition involving benign tumors pathologically characterized by multiple blood-filled cavities, mostly affecting the liver and spleen. Androgenic-steroids are widely used in patients with bone marrow failure syndromes (e.g.: aplastic anemia) and these patients are at increased risk of developing PH. Although patients with PH are generally asymptomatic, PH can progress to liver failure and even fatal spontaneous intraabdominal hemorrhage. Therefore, early diagnosis is critical in order to prevent life-threatening complications of PH. We herein report a patient with PH which had been treated with danazol, who presented with liver dysfunction and multiple hepatic lesions on imaging studies at the time of diagnosis. Although the patient presented with disseminated intravascular coagulation (DIC), a bone marrow biopsy revealed no evidence of leukemic transformation. The patient was diagnosed as having danazol-induced PH, and these abnormalities spontaneously resolved after the discontinuation of danazol. PH is one of the most important complications of long-term administration of androgenic-steroids. Although the mechanisms remain unclear, the multiple blood-filled cavities characteristic of PH may be responsible for the development of DIC. Therefore, monitoring of coagulation markers might also be a key strategy for early diagnosis of PH.
[Mh] MeSH terms primary: Anemia, Aplastic/etiology
Bone Marrow Diseases/etiology
Danazol/adverse effects
Disseminated Intravascular Coagulation/etiology
Hemoglobinuria, Paroxysmal/etiology
Peliosis Hepatis/chemically induced
[Mh] MeSH terms secundary: Aged, 80 and over
Female
Humans
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:N29QWW3BUO (Danazol)
[Em] Entry month:1702
[Cu] Class update date: 171018
[Lr] Last revision date:171018
[Js] Journal subset:IM
[Da] Date of entry for processing:160908
[St] Status:MEDLINE
[do] DOI:10.11406/rinketsu.57.1026


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