Database : MEDLINE
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[PMID]: 29216611
[Au] Autor:Biundo B
[Ad] Address:Professional Compounding Centers of America, Houston, Texas. bbiundo@pccarx.com.
[Ti] Title:Compounding Opportunities in Urology.
[So] Source:Int J Pharm Compd;21(5):358-362, 2017 Sep-Oct.
[Is] ISSN:1092-4221
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:There are a lot of options that pharmacists, including compounding pharmacists, can offer urologists to assist their patients. Compounding pharmacists are in a great position to offer unique, effective preparations for many of the conditions urologists treat on a daily basis. It would be well worth the time to learn a little about the conditions these specialists treat and become familiar with what you can offer.
[Mh] MeSH terms primary: Drug Compounding
Pharmacists
Urology
[Mh] MeSH terms secundary: Cystitis, Interstitial/drug therapy
Erectile Dysfunction/drug therapy
Humans
Infertility/drug therapy
Male
Pelvic Pain/drug therapy
Penile Induration/drug therapy
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[Js] Journal subset:IM
[Da] Date of entry for processing:171208
[St] Status:MEDLINE

  2 / 1689 MEDLINE  
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[PMID]: 29333517
[Au] Autor:Matz EL; Pearlman AM; Terlecki RP
[Ad] Address:Department of Urology, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
[Ti] Title:Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions.
[So] Source:Investig Clin Urol;59(1):61-65, 2018 Jan.
[Is] ISSN:2466-054X
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Purpose: Autologous platelet rich plasma (PRP) is used increasingly in a variety of settings. PRP injections have been used for decades to improve angiogenesis and wound healing. They have also been offered commercially in urology with little to no data on safety or efficacy. PRP could theoretically improve multiple urologic conditions, such as erectile dysfunction (ED), Peyronie's disease (PD), and stress urinary incontinence (SUI). A concern with PRP, however, is early washout, a situation potentially avoided by conversion to platelet rich fibrin matrix (PRFM). Before clinical trials can be performed, safety analysis is desirable. We reviewed an initial series of patients receiving PRFM for urologic pathology to assess safety and feasibility. Materials and Methods: Data were reviewed for patients treated with PRFM at our center from November 2012 to July 2017. Patients were observed immediately post-injection and at follow-up for complications and tolerability. Where applicable, International Index of Erectile Function (IIEF-5) scores were reviewed before and after injections for ED and/or PD. Pad use data was collected pre/post injection for SUI. Results: Seventeen patients were identified, with a mean receipt of 2.1 injections per patient. Post-procedural minor adverse events were seen in 3 men, consisting of mild pain at injection site and mild penile bruising. No patients experienced complications at follow-up. No decline was observed in men completing pre/post IIEF-5 evaluations. Conclusions: PRFM appears to be a safe and feasible treatment modality in patients with urologic disease. Further placebo-controlled trials are warranted.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180117
[Lr] Last revision date:180117
[St] Status:In-Data-Review
[do] DOI:10.4111/icu.2018.59.1.61

  3 / 1689 MEDLINE  
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[PMID]: 29230262
[Au] Autor:Touzani MA; Yddoussalah O
[Ad] Address:Université Mohammed 5, Faculté de Médecine et de Pharmacie de Rabat, Hopital Ibn Sina, Service d'Urologie B, Maroc.
[Ti] Title:Métastase caverneuse d'une tumeur de vessie. [Cavernous metastasis from blader tumor].
[So] Source:Pan Afr Med J;28:60, 2017.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:fre
[Ab] Abstract:The incidence of cavernous metastases after radical treatment for bladder tumor is exceptional and is approximately 1%. The mean time between surgery and the occurrence of metastases is 8 months. In some cases they occur after 10 years. Diagnosis is confirmed by biopsy, which shows their urothelial origin. Here we report the case of 56-year old patient, with a history of smoking, having undergone total cystoprostatectomy in January 2017, who presented 2 months later with induratio penis plastica with no other sign associated. Priapism and gangrene of the penis of infectious origin have been suspected but, given the patient's clinical condition, the more likely diagnosis was cavernous metastasis. On two occasions the patient refused biopsy: during two consultations at 15 days interval (A, B). The patient accepted to undergo biopsy during the 3 consultation (C, D). Biopsy confirmed the diagnosis of cavernous metastasis.
[Mh] MeSH terms primary: Cystectomy/methods
Penile Neoplasms/diagnosis
Prostatectomy/methods
Urinary Bladder Neoplasms/pathology
[Mh] MeSH terms secundary: Biopsy
Humans
Male
Middle Aged
Penile Induration/diagnosis
Penile Induration/etiology
Penile Neoplasms/pathology
Penile Neoplasms/secondary
Time Factors
Urinary Bladder Neoplasms/surgery
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171222
[Lr] Last revision date:171222
[Js] Journal subset:IM
[Da] Date of entry for processing:171213
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.60.13244

  4 / 1689 MEDLINE  
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[PMID]: 27770853
[Au] Autor:Trost LW; Munarriz R; Wang R; Morey A; Levine L
[Ad] Address:Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address: Trost.Landon@mayo.edu.
[Ti] Title:External Mechanical Devices and Vascular Surgery for Erectile Dysfunction.
[So] Source:J Sex Med;13(11):1579-1617, 2016 11.
[Is] ISSN:1743-6109
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: The field of sexual medicine is continuously advancing, with novel outcomes reported on a regular basis. Given the rapid evolution, updated guidelines are essential to inform practicing clinicians on best practices. AIM: To summarize the current literature and provide clinical guidelines on penile traction therapy, vacuum erection devices, and penile revascularization. METHODS: A consensus panel was held with leading sexual medicine experts during the 2015 International Consultation on Sexual Medicine (ICSM). Relevant literature was reviewed and graded based on Oxford criteria to develop evidence-based guideline and consensus statements. MAIN OUTCOME MEASURES: The development of clinically relevant guidelines. RESULTS: Penile traction therapy is a viable therapy to modestly improve penile length as a primary therapy, before penile prosthesis placement in men with decreased penile length or after surgery for Peyronie's disease. It also might have a role in the acute phase of Peyronie's disease but has inconsistent outcomes in the long-term phase. Vacuum erection devices are effective in creating an erection satisfactory for intercourse, even in difficult-to-treat populations. They also might be used in the post-prostatectomy setting to maintain penile length but have insufficient evidence as a penile rehabilitation therapy. For vasculogenic erectile dysfunction, men with suspected arterial insufficiency can be evaluated with penile Duplex Doppler ultrasonography and confirmatory angiography. Penile revascularization procedures have consistently demonstrated benefits in very select patient populations; however, inadequate data exists to suggest the superiority of one technique. Men with vascular risk factors are likely poor candidates for penile revascularization, although veno-occlusive dysfunction and age are less significant. Therapies for treating primary veno-occlusive dysfunction are not recommended and should be reserved for clinical trials. CONCLUSIONS: Since the prior ICSM meeting, multiple developments have occurred in external mechanical devices and penile revascularization for the treatment of erectile and sexual dysfunction. Sexual medicine clinicians are encouraged to review and incorporate recommendations as applicable to their scope of practice.
[Mh] MeSH terms primary: Erectile Dysfunction/therapy
Penile Induration/surgery
Vascular Surgical Procedures/methods
[Mh] MeSH terms secundary: Consensus
Erectile Dysfunction/etiology
Erectile Dysfunction/physiopathology
Humans
Male
Microsurgery/methods
Penile Erection/physiology
Penile Implantation/instrumentation
Penile Implantation/methods
Penile Prosthesis
Penis/blood supply
Penis/surgery
Prostatectomy/adverse effects
Referral and Consultation
Reperfusion/methods
Risk Factors
Sexual Behavior
Vacuum
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1706
[Cu] Class update date: 171207
[Lr] Last revision date:171207
[Js] Journal subset:IM
[Da] Date of entry for processing:161025
[St] Status:MEDLINE

  5 / 1689 MEDLINE  
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[PMID]: 28460995
[Au] Autor:Margolin EJ; Mlynarczyk CM; Mulhall JP; Stember DS; Stahl PJ
[Ad] Address:Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA. Electronic address: ejm2182@columbia.edu.
[Ti] Title:Three-Dimensional Photography for Quantitative Assessment of Penile Volume-Loss Deformities in Peyronie's Disease.
[So] Source:J Sex Med;14(6):829-833, 2017 Jun.
[Is] ISSN:1743-6109
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Non-curvature penile deformities are prevalent and bothersome manifestations of Peyronie's disease (PD), but the quantitative metrics that are currently used to describe these deformities are inadequate and non-standardized, presenting a barrier to clinical research and patient care. AIM: To introduce erect penile volume (EPV) and percentage of erect penile volume loss (percent EPVL) as novel metrics that provide detailed quantitative information about non-curvature penile deformities and to study the feasibility and reliability of three-dimensional (3D) photography for measurement of quantitative penile parameters. METHODS: We constructed seven penis models simulating deformities found in PD. The 3D photographs of each model were captured in triplicate by four observers using a 3D camera. Computer software was used to generate automated measurements of EPV, percent EPVL, penile length, minimum circumference, maximum circumference, and angle of curvature. The automated measurements were statistically compared with measurements obtained using water-displacement experiments, a tape measure, and a goniometer. OUTCOMES: Accuracy of 3D photography for average measurements of all parameters compared with manual measurements; inter-test, intra-observer, and inter-observer reliabilities of EPV and percent EPVL measurements as assessed by the intraclass correlation coefficient. RESULTS: The 3D images were captured in a median of 52 seconds (interquartile range = 45-61). On average, 3D photography was accurate to within 0.3% for measurement of penile length. It overestimated maximum and minimum circumferences by averages of 4.2% and 1.6%, respectively; overestimated EPV by an average of 7.1%; and underestimated percent EPVL by an average of 1.9%. All inter-test, inter-observer, and intra-observer intraclass correlation coefficients for EPV and percent EPVL measurements were greater than 0.75, reflective of excellent methodologic reliability. CLINICAL TRANSLATION: By providing highly descriptive and reliable measurements of penile parameters, 3D photography can empower researchers to better study volume-loss deformities in PD and enable clinicians to offer improved clinical assessment, communication, and documentation. STRENGTHS AND LIMITATIONS: This is the first study to apply 3D photography to the assessment of PD and to accurately measure the novel parameters of EPV and percent EPVL. This proof-of-concept study is limited by the lack of data in human subjects, which could present additional challenges in obtaining reliable measurements. CONCLUSION: EPV and percent EPVL are novel metrics that can be quickly, accurately, and reliably measured using computational analysis of 3D photographs and can be useful in describing non-curvature volume-loss deformities resulting from PD. Margolin EJ, Mlynarczyk CM, Muhall JP, et al. Three-Dimensional Photography for Quantitative Assessment of Penile Volume-Loss Deformities in Peyronie's Disease. J Sex Med 2017;14:829-833.
[Mh] MeSH terms primary: Image Processing, Computer-Assisted/methods
Penile Induration/pathology
Photography/methods
[Mh] MeSH terms secundary: Humans
Male
Prevalence
Reproducibility of Results
Time Factors
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171128
[Lr] Last revision date:171128
[Js] Journal subset:IM
[Da] Date of entry for processing:170503
[St] Status:MEDLINE

  6 / 1689 MEDLINE  
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[PMID]: 29110729
[Au] Autor:Efared B; Ebang GA; Tahirou S; Tahiri L; Sidibé IS; Erregad F; Sow A; Hammas N; Farih MH; Chbani L; El Fatemi H
[Ad] Address:Department of Pathology, Hassan II University Hospital, Fès, Morocco. befared2013@gmail.com.
[Ti] Title:Penile metastasis from rectal adenocarcinoma: a case report.
[So] Source:BMC Res Notes;10(1):564, 2017 Nov 06.
[Is] ISSN:1756-0500
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Despite its rich vasculature, the penis is rarely involved by metastasis. Since the first description of penile metastasis in 1870, fewer than 500 cases have been reported in the literature. The pelvic organs are the main source of primary tumors that metastasize to the penis. CASE PRESENTATION: We report a case of a 46-year-old Arabic man who presented with erectile dysfunction and painful induration of the penile root. Eight months ago, he had undergone abdomino-perineal resection for rectal adenocarcinoma after neo-adjuvant chemotherapy. The histological evaluation of the resected specimen disclosed a ypT3N0 tumor with a poor therapeutic response (around 5%). An adjuvant chemotherapy by XELOX (oxaliplatin plus capecitabine) regimen has been prescribed for the patient. The magnetic resonance imaging (MRI) showed tumoral infiltration of penile structures and a biopsy of the corpora cavernosa was performed. The histological examination disclosed a penile metastasis from the patient's previous rectal adenocarcinoma. The patient is still alive and continues his adjuvant therapy. CONCLUSION: Penile secondary tumors are very rare and usually occur in patients with advanced tumor stages. A diagnosis of penile metastasis should be considered in patients with a history of malignancies who present with genitourinary symptoms. These patients have a dismal prognosis as they often die in the year after the diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[St] Status:In-Process
[do] DOI:10.1186/s13104-017-2901-5

  7 / 1689 MEDLINE  
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[PMID]: 29080947
[Au] Autor:Svensøy JN; Travers V; Osther PJS
[Ad] Address:Lege Svensøy, Oslo, Norway. JohannesSvensoy@gmail.com.
[Ti] Title:Complications of penile self-injections: investigation of 680 patients with complications following penile self-injections with mineral oil.
[So] Source:World J Urol;, 2017 Oct 28.
[Is] ISSN:1433-8726
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Penile implants and injection of foreign materials have been described in texts like Kama Sutra for more than 1500 years, and are still being practiced around the world. The extent of this practice is unknown, and the documentation available today only scratches the surface. This study investigates and documents the complications after penile self-injections at the Mae Tao Clinic. To our knowledge, this study represents the largest series of patients representing complications to penile self-injections. STUDY DESIGN: Retrospective study. METHODS: We investigated data on 680 patients admitted with penile self-injections during a 5-year period. Data were studied for general patient data, symptoms, time of injection, and treatment. RESULTS: Age at admittance ranged from 17 to 68 with a mean age of 32 years. Time between injection and presentation was registered with a mean of 36.7 months, over half presented with complications within 1 year. Most frequent complications were penile pain (84%), swelling (82.5%), induration (42.9%), purulent secretion (21.8%), and ulceration (12.8%). Of the 680 patients, 507 (74.6%) underwent surgical treatment (503 excision and 4 circumcision), while 173 (25.4%) were treated conservatively. CONCLUSION: Our data suggest that penile self-injections with mineral oil are more prevalent in certain areas than previously acknowledged. In 5 years, more than 680 patients presented with complications to penile self-injections, of which 75% needed surgical intervention, mainly in the form of radical excision of the lesions followed by skin grafting. Preventive measures to this physically and psychologically devastating problem are highly warranted.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171029
[Lr] Last revision date:171029
[St] Status:Publisher
[do] DOI:10.1007/s00345-017-2110-9

  8 / 1689 MEDLINE  
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[PMID]: 28952696
[Au] Autor:Kotov SV; Yusufov AG; Semenov MK
[Ad] Address:N.I. Pirogov RNRMU of Minzdrav of Russia, Moscow, Russia.
[Ti] Title:[Buccal mucosa transplant the concept of ideal graft in surgical management of peyronies disease].
[So] Source:Urologiia;(4):68-72, 2017 Sep.
[Is] ISSN:1728-2985
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:INTRODUCTION: Surgical techniques in managing Peyronies disease include plication corporoplasty, plaque incision, grafting and penile prosthesis implantation. The question of an ideal transplant for corporoplasty remains open. AIM: To evaluate the effectiveness of the substitution corporoplasty using buccal mucosa transplant (BMT) in treating Peyronies disease. MATERIALS AND METHODS: From January 2011 to February 2016, 28 patients with stable stage Peyronies disease underwent substitution coroproplasty using BMT (incision and grafting). The mean age of patients was 54.8+/-6.2 years. All patients completed an IIEF-5 questionnaire and underwent a standard preoperative examination: anamnesis, physical examination, penile duplex pharmaco-ultrasonography and penile fixation photography to assess the type and angle of curvature. The average angle of penile curvature was 82.8 (45-120). All patients underwent incision and grafting using BMT; in 5 patients additionally the plication of the penile tunica albuginea was performed. Follow-up examinations were concluded at 3, 6 and 12 months and more after surgery. RESULTS: Median follow-up was 30 months. Postoperative penile straightening was achieved in 93% of patients. The duplex peak systolic velocity of the right and left cavernosal arteries improved from 42.59 to 45.64 cm/s and from 34.55 to 43.48 cm/s, respectively (p less or equal 0.05). CONCLUSION: Penile corproroplasty using BMT is a safe and effective method of treating patients with Peyronies disease. Follow-up clinical and instrumental examination showed no impairment of the erectile function or penile hemodynamics.
[Mh] MeSH terms primary: Mouth Mucosa/transplantation
Penile Induration/surgery
[Mh] MeSH terms secundary: Humans
Male
Middle Aged
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[Js] Journal subset:IM
[Da] Date of entry for processing:170928
[St] Status:MEDLINE

  9 / 1689 MEDLINE  
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[PMID]: 28879693
[Au] Autor:Gabrielson AT; Alzweri LM; Hellstrom WJ
[Ad] Address:Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
[Ti] Title:Collagenase Clostridium Histolyticum in the Treatment of Peyronie's Disease: Review of a Minimally Invasive Treatment Option.
[So] Source:World J Mens Health;, 2017 09 06.
[Is] ISSN:2287-4208
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Peyronie's disease (PD) is an inflammatory disorder characterized by an abnormal collagen deposition in the tunica albuginea of the penis, leading to fibrous and non-compliant plaques that can impede normal erection. Although pharmacological treatments are available, only intralesional injection therapy and surgical reconstruction have demonstrated tangible clinical efficacy in the management of this condition. Intralesional injection of collagenase clostridium histolyticum (CCH) has come to the forefront of minimally invasive treatment of PD. In this review, the authors provide an update on the safety, efficacy, and indications for CCH. The efficacy of CCH will be assessed on the basis of improvement in the severity of penile fibrosis, curvature, and pain. Numerous well-designed clinical trials and post-approval studies involving more than 1,500 patients have consistently demonstrated the efficacy and tolerability of CCH in the treatment of PD. CCH significantly decreases penile curvature and plaque consistency, as well as improves quality of life. Post-approval studies continue to demonstrate the efficacy of CCH despite broader inclusion criteria for treatment, such as the case with acute phase disease and atypical plaque deformities (i.e., ventral plaques, hourglass narrowing). CCH continues to be the gold standard for non-surgical management of stable phase PD, in the absence of strong evidence supporting oral therapy agents and ongoing evaluation of extracorporeal shockwave therapy. However, recent studies are beginning to provide precedent for the use of CCH in the management of acute phase and atypical PD.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1709
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[St] Status:Publisher
[do] DOI:10.5534/wjmh.17033

  10 / 1689 MEDLINE  
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[PMID]: 28727375
[Au] Autor:Ozkuvanci Ü; Ziylan O; Dönmez MI; Yucel OB; Oktar T; Ander H; Nane I
[Ad] Address:Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
[Ti] Title:An unanswered question in pediatric urology: the post pubertal persistence of prepubertal congenital penile curvature correction by tunical plication.
[So] Source:Int Braz J Urol;43(5):925-931, 2017 Sep-Oct.
[Is] ISSN:1677-6119
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of this study is to analyze post pubertal results of pre pubertal tunica albuginea plication with non-absorbable sutures in the correction of CPC. MATERIALS AND METHODS: The files of patients who underwent tunica albuginea plication without incision (dorsal/lateral) were retrospectively reviewed. Patients younger than 13 years of age at the time of operation and older than 14 years of age in November 2015 were included. Patients with a penile curvature of less than 30 degrees & more than 45 degrees and penile/urethral anomalies were excluded. All of the patients underwent surgery followed by circumcision. RESULTS: The mean age of patients at the time of the operation was 9.7 years (range, 6-13 years). The mean degree of ventral penile curvature measured during the operation was 39 degrees while it was 41 degrees in the lateral curvatures. All of the patients were curvature-free at the end of the operation. At the time of the follow-up examination, the mean age was 16.7 years (range, 14-25 years). Six patients had a straight (0-10 degrees) penis during erection and seven patients had recurrent penile curvatures ranging from 30 to 50 degrees. CONCLUSION: Pre pubertal tunica albuginea plication of congenital penile curvature (30-45 degrees) with non-absorbable sutures performed without incision is a minimal invasive method especially when performed during circumcision. However, recurrence might be observed in half of the patients after puberty.
[Mh] MeSH terms primary: Penile Diseases/congenital
Penile Diseases/surgery
Penis/abnormalities
Penis/surgery
Urologic Surgical Procedures, Male/methods
[Mh] MeSH terms secundary: Adolescent
Humans
Male
Retrospective Studies
Suture Techniques
Time Factors
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171117
[Lr] Last revision date:171117
[Js] Journal subset:IM
[Da] Date of entry for processing:170721
[St] Status:MEDLINE
[do] DOI:10.1590/S1677-5538.IBJU.2017.0055


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