Database : MEDLINE
Search on : pestivirus and infections [Words]
References found : 709 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 71 go to page                         

  1 / 709 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29325885
[Au] Autor:Loddo R; Francesconi V; Laurini E; Boccardo S; Aulic S; Fermeglia M; Pricl S; Tonelli M
[Ad] Address:Department of Biomedical Sciences and Technology, University of Cagliari, Cittadella Universitaria, 09042 Monserrato CA, Italy. Electronic address: rloddo@unica.it.
[Ti] Title:9-Aminoacridine-based agents impair the bovine viral diarrhea virus (BVDV) replication targeting the RNA-dependent RNA polymerase (RdRp).
[So] Source:Bioorg Med Chem;26(4):855-868, 2018 Feb 15.
[Is] ISSN:1464-3391
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Bovine viral diarrhea virus (BVDV) infection is still a plague that causes important livestock pandemics. Despite the availability of vaccines against BVDV, and the implementation of massive eradication or control programs, this virus still constitutes a serious agronomic burden. Therefore, the alternative approach to combat Pestivirus infections, based on the development of antiviral agents that specifically inhibit the replication of these viruses, is of preeminent actuality and importance. Capitalizing from a long-standing experience in antiviral drug design and development, in this work we present and characterize a series of small molecules based on the 9-aminoacridine scaffold that exhibit potent anti-BVDV activity coupled with low cytotoxicity. The relevant viral protein target - the RNA-dependent RNA polymerase - the binding mode, and the mechanism of action of these new antivirals have been determined by a combination of in vitro (i.e., enzymatic inhibition, isothermal titration calorimetry and site-directed mutagenesis assays) and computational experiments. The overall results obtained confirm that these acridine-based derivatives are promising compounds in the treatment of BVDV infections and, based on the reported structure-activity relationship, can be selected as a starting point for the design of a new generation of improved, safe and selective anti-BVDV agents.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:In-Data-Review

  2 / 709 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29329686
[Au] Autor:Ebranati E; Lauzi S; Cerutti F; Caruso C; Masoero L; Moreno A; De Mia GM; Peletto S; Zehender G; Luzzago C
[Ad] Address:Department of Clinical Sciences "Luigi Sacco", Section of Infectious Diseases, University of Milan, Via G.B. Grassi 74, 20157 Milan, Italy; CRC-Coordinated Research Center "EpiSoMI", University of Milan, Milano, Italy.
[Ti] Title:Highlighting priority areas for bovine viral diarrhea control in Italy: A phylogeographic approach.
[So] Source:Infect Genet Evol;58:258-268, 2018 Mar.
[Is] ISSN:1567-7257
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The prevalence and genetic diversity of bovine viral diarrhea virus (BVDV) in a geographic area are largely influenced by live animal trade and management practices. Despite control and eradication programs currently underway in several European countries, the risk of BVDV spread within and among countries is still present. BVDV-1 is the predominant type circulating in European cattle population. In this study, a phylogeographic analysis was applied to the BVDV-1 highest prevalent subtypes in Italy to reconstruct the origin and spatial-temporal distribution and to trace main viral flows between different locations to highlight priority areas for BVDV control. A comprehensive dataset of BVDV-1b (n = 173) and 1e (n = 172) 5' UTR sequences was analysed, including both novel and published sequences from Italy and from European countries bordering and/or with commercial cattle flows with Italy. A common phylogeographic pattern was observed for BVDV-1b and 1e subtypes: interspersion from multiple Italian areas and European countries was widespread until the end of the last century, whereas significant local clusters were observed starting from 2000. These findings support a continuous viral flow among different areas over long time scales with no evidence of significant geographical structure, while local transmission networks are limited to more recent years. Northern Italy has been confirmed as the area of origin of the main clades of both BVDV subtypes at national level, acting both as a crucial area for introduction and a maintenance source for other areas. Piedmont, Central and Southern Italian regions contributed to limited geographical distribution and local BVDV-1b and 1e persistence. On the whole, priority control measures for BVDV-1b and 1e in Italy should be focused on: i) implementation of BVDV systematic control in all Northern Italian regions to break the viral flow from larger to smaller animal populations; and ii) breaking the dynamics of infections in regions with self-maintenance of BVDV by voluntary control programs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:In-Data-Review

  3 / 709 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29031833
[Au] Autor:Pascual MJ; Merwaiss F; Leal E; Quintana ME; Capozzo AV; Cavasotto CN; Bollini M; Alvarez DE
[Ad] Address:Instituto de Investigaciones Biotecnolgicas, CONICET, Universidad Nacional de San Martn, Argentina.
[Ti] Title:Structure-based drug design for envelope protein E2 uncovers a new class of bovine viral diarrhea inhibitors that block virus entry.
[So] Source:Antiviral Res;, 2017 Oct 12.
[Is] ISSN:1872-9096
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Antiviral targeting of virus envelope proteins is an effective strategy for therapeutic intervention of viral infections. Here, we took a computer-guided approach with the aim of identifying new antivirals against the envelope protein E2 of bovine viral diarrhea virus (BVDV). BVDV is an enveloped virus with an RNA genome responsible for major economic losses of the cattle industry worldwide. Based on the crystal structure of the envelope protein E2, we defined a binding site at the interface of the two most distal domains from the virus membrane and pursued a hierarchical docking-based virtual screening search to identify small-molecule ligands of E2. Phenyl thiophene carboxamide derivative 12 (PTC12) emerged as a specific inhibitor of BVDV replication from in vitro antiviral activity screening of candidate molecules, displaying an IC of 0.30M against the reference NADL strain of the virus. Using reverse genetics we constructed a recombinant BVDV expressing GFP that served as a sensitive reporter for the study of the mechanism of action of antiviral compounds. Time of drug addition assays showed that PTC12 inhibited an early step of infection. The mechanism of action was further dissected to find that the compound specifically acted at the internalization step of virus entry. Interestingly, we demonstrated that similar to PTC12, the benzimidazole derivative 03 (BI03) selected in the virtual screen also inhibited internalization of BVDV. Furthermore, docking analysis of PTC12 and BI03 into the binding site revealed common interactions with amino acid residues in E2 suggesting that both compounds could share the same molecular target. In conclusion, starting from a targeted design strategy of antivirals against E2 we identified PTC12 as a potent inhibitor of BVDV entry. The compound can be valuable in the design of antiviral strategies in combination with already well-characterized polymerase inhibitors of BVDV.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171016
[Lr] Last revision date:171016
[St] Status:Publisher

  4 / 709 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28795249
[Au] Autor:Falkenberg SM; Bauermann FV; Ridpath JF
[Ad] Address:Ruminant Disease and Immunology Research Unit, National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, IA, 50010, USA. Shollie.Falkenberg@ars.usda.gov.
[Ti] Title:Characterization of thymus-associated lymphoid depletion in bovine calves acutely or persistently infected with bovine viral diarrhea virus 1, bovine viral diarrhea virus 2 or HoBi-like pestivirus.
[So] Source:Arch Virol;162(11):3473-3480, 2017 Nov.
[Is] ISSN:1432-8798
[Cp] Country of publication:Austria
[La] Language:eng
[Ab] Abstract:Nave pregnant cattle exposed to pestiviruses between 40-125days of gestation can give birth to persistently infected (PI) calves. Clinical presentation and survivability, in PI cattle, is highly variable even with the same pestivirus strain whereas the clinical presentation in acute infections is more uniform with severity of symptoms being primarily a function of virulence of the infecting virus. The aim of this study was to compare thymic depletion, as measured by comparing the area of the thymic cortex to the medulla (corticomedullary ratio), in acute and persistent infections of the same pestivirus isolate. The same general trends were observed with each pestivirus isolate. Thymic depletion was observed in both acutely and persistently infected calves. The average thymic depletion observed in acutely infected calves was greater than that in age matched PI calves. PI calves, regardless of infecting virus, revealed a greater variability in amount of depletion compared to acutely infected calves. A trend was observed between survivability and depletion of the thymus, with PI calves surviving less than 5weeks having lower corticomedullary ratios and greater depletion. This is the first study to compare PI and acutely infected calves with the same isolates as well as to evaluate PI calves based on survivability. Further, this study identified a quantifiable phenotype associated with potential survivability.
[Mh] MeSH terms primary: Diarrhea Virus 1, Bovine Viral
Diarrhea Virus 2, Bovine Viral
Lymphocytes/pathology
Pestivirus Infections/veterinary
Pestivirus/classification
Thymus Gland/cytology
[Mh] MeSH terms secundary: Animals
Cattle
Diarrhea Virus 1, Bovine Viral/pathogenicity
Diarrhea Virus 2, Bovine Viral/pathogenicity
Pestivirus/pathogenicity
Pestivirus Infections/pathology
Pestivirus Infections/virology
Thymus Gland/pathology
Thymus Gland/virology
Virulence
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171027
[Lr] Last revision date:171027
[Js] Journal subset:IM
[Da] Date of entry for processing:170811
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3523-x

  5 / 709 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28786787
[Au] Autor:Smith DB; Meyers G; Bukh J; Gould EA; Monath T; Scott Muerhoff A; Pletnev A; Rico-Hesse R; Stapleton JT; Simmonds P; Becher P
[Ad] Address:1​Centre for Immunity, Infection and Evolution, University of Edinburgh, Scotland, UK 2​Nuffield Department of Medicine, University of Oxford, UK.
[Ti] Title:Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae.
[So] Source:J Gen Virol;98(8):2106-2112, 2017 Aug.
[Is] ISSN:1465-2099
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:We propose the creation of seven new species in the genus Pestivirus (family Flaviviridae) in addition to the four existing species, and naming species in a host-independent manner using the format Pestivirus X. Only the virus species names would change; virus isolates would still be referred to by their original names. The original species would be re-designated as Pestivirus A (original designation Bovine viral diarrhea virus 1), Pestivirus B (Bovine viral diarrhea virus 2), Pestivirus C (Classical swine fever virus) and Pestivirus D (Border disease virus). The seven new species (and example isolates) would be Pestivirus E (pronghorn pestivirus), Pestivirus F (Bungowannah virus), Pestivirus G (giraffe pestivirus), Pestivirus H (Hobi-like pestivirus), Pestivirus I (Aydin-like pestivirus), Pestivirus J (rat pestivirus) and Pestivirus K (atypical porcine pestivirus). A bat-derived virus and pestiviruses identified from sheep and goat (Tunisian sheep pestiviruses), which lack complete coding region sequences, may represent two additional species.
[Mh] MeSH terms primary: Pestivirus Infections/veterinary
Pestivirus/classification
Pestivirus/isolation & purification
[Mh] MeSH terms secundary: Animals
Cattle
Goats
Pestivirus/genetics
Pestivirus/physiology
Pestivirus Infections/virology
Phylogeny
Rats
Sheep
Swine
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:170809
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000873

  6 / 709 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28768435
[Au] Autor:Galabov AS; Mukova L; Abashev YP; Wassilewa L; Tzvetkov P; Minkov V; Barinskiy IF; Rice CM; Ouzounov S; Sidzhakova D
[Ad] Address:1 The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
[Ti] Title:Cycluridine: A novel antiviral effective against flaviviruses.
[So] Source:Antivir Chem Chemother;25(2):58-67, 2017 Aug.
[Is] ISSN:2040-2066
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This review describes the contemporary state of research for antivirals effective against flaviviruses, especially focusing on inhibitors of the pestivirus causative agent of bovine viral diarrhoea virus. We highlight cycluridine, an originally synthesized Mannich's base [a tetrahydro-2(1H)-pyrimidinones derivative], as a highly effective antiviral possessing a strong inhibitory effect on bovine viral diarrhoea virus replication. Cycluridine was active against replication of a wide variety of bovine viral diarrhoea virus strains in cell cultures. The drug-sensitive period in the bovine viral diarrhoea virus replication cycle included the latent period and the exponential phase; a 90-min delay in the peak of viral RNA synthesis was observed. Cycluridine administered orally manifested a pronounced protective effect in calves with natural mucosal disease/viral diarrhoea and calves experimentally infected with bovine viral diarrhoea virus. Its magnitude of activity and selectivity places cycluridine in the lead among all known substances with anti- bovine viral diarrhoea virus activity. Additionally, cycluridine applied subcutaneously showed anti-tick-born encephalitis virus activity, manifesting a marked protective effect in mice infected with tick-born encephalitis virus. Cycluridine could be a prospective antiviral in veterinary and medical practice for the treatment of bovine viral diarrhoea virus and other flavivirus infections.
[Mh] MeSH terms primary: Antiviral Agents/pharmacology
Flavivirus/drug effects
Uridine/pharmacology
[Mh] MeSH terms secundary: Animals
Antiviral Agents/chemistry
Antiviral Agents/therapeutic use
Flavivirus/physiology
Flavivirus Infections/drug therapy
Humans
Uridine/chemistry
Uridine/therapeutic use
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Antiviral Agents); WHI7HQ7H85 (Uridine)
[Em] Entry month:1708
[Cu] Class update date: 170811
[Lr] Last revision date:170811
[Js] Journal subset:IM
[Da] Date of entry for processing:170804
[St] Status:MEDLINE
[do] DOI:10.1177/2040206617723442

  7 / 709 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28758367
[Au] Autor:Silveira S; Baumbach LF; Weber MN; Msena ACS; da Silva MS; Cibulski SP; Borba MR; Maia RD; Coimbra VCS; de Moraes GM; Ridpath JF; Canal CW
[Ad] Address:Laboratrio de Virologia, Faculdade de Veterinria, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
[Ti] Title:HoBi-like is the most prevalent ruminant pestivirus in Northeastern Brazil.
[So] Source:Transbound Emerg Dis;, 2017 Jul 30.
[Is] ISSN:1865-1682
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The ruminant pestiviral species BVDV-1, BVDV-2 and BDV, along with the putative species HoBi-like, may cause substantial economic losses in cattle, sheep and goats. Brazil's large size, variable biomes and wide range of ruminant animal production within different geographic regions suggest that the presence and prevalence of ruminant pestivirus may differ by regions within Brazil. This study investigated the genetic diversity of ruminant pestiviruses and determined the frequency of active infections within two states of the Northeast Region of Brazil, Maranho and Rio Grande do Norte. Serum samples from 16,621 cattle and 2,672 small ruminants from 569 different herds residing in this region were tested by RT-PCR followed by DNA sequencing. Seventeen positive cattle were detected (0.1%) from fifteen different herds (2.64%). All isolates were classified as HoBi-like pestiviruses based on phylogenetic analysis. All small ruminant samples tested negative. The findings presented herein suggest that the Northeast Region of Brazil has a uniquely high prevalence of HoBi-like viruses. The increasing reports of HoBi-like viruses detected in cattle in the field suggest that natural infection with these viruses may be more widespread than previously thought. The identification of HoBi-like viruses as the most prevalent type of ruminant pestivirus circulating in the Northeast Region of Brazil indicates the need for both continued monitoring and determination of the extent of economic losses associated with HoBi-like virus infections. In addition, it must be taken into account in the choice of diagnostic tests and in vaccine formulations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170731
[Lr] Last revision date:170731
[St] Status:Publisher
[do] DOI:10.1111/tbed.12689

  8 / 709 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28688346
[Au] Autor:Falkenberg SM; Dassanayake RP; Neill JD; Ridpath JF
[Ad] Address:Ruminant Disease and Immunology Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, United States. Electronic address: Shollie.Falkenberg@ars.usda.gov.
[Ti] Title:Improved detection of bovine viral diarrhea virus in bovine lymphoid cell lines using PrimeFlow RNA assay.
[So] Source:Virology;509:260-265, 2017 Sep.
[Is] ISSN:1096-0341
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Bovine viral diarrhea virus (BVDV) infections, whether as acute, persistent or contributing to co-infections, result in significant losses for cattle producers. Although, BVDV can be identified readily by real-time PCR and ELISA, detection and quantification of viral infection at the single cell level is extremely difficult. Detection at the single lymphoid cell level is important due to the immunomodulation that accompanies BVDV infection. A novel PrimeFlow RNA assay using in-situ detection of BVDV was evaluated. The model used to develop this technique included three BL-3 cell lines with different infection statuses, one not infected with BVDV, one infected with BVDV and one dual infected with BVDV and bovine leukosis virus. Using RNA probes specific for the BVDV-2a N -E coding region, BVDV RNA was detected from both contaminated BL-3 cell lines by flow cytometry and fluorescent microscopy. This is the first report on in-situ detection of BVDV at the single-cell level.
[Mh] MeSH terms primary: Diarrhea Viruses, Bovine Viral/isolation & purification
Flow Cytometry/methods
Lymphocytes/virology
Microscopy, Fluorescence/methods
RNA, Viral/analysis
Single-Cell Analysis/methods
[Mh] MeSH terms secundary: Animals
Cattle
Diarrhea Viruses, Bovine Viral/genetics
Virology/methods
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (RNA, Viral)
[Em] Entry month:1707
[Cu] Class update date: 170721
[Lr] Last revision date:170721
[Js] Journal subset:IM
[Da] Date of entry for processing:170709
[St] Status:MEDLINE

  9 / 709 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28532992
[Au] Autor:Byrne AW; Guelbenzu-Gonzalo M; Strain SAJ; McBride S; Graham J; Lahuerta-Marin A; Harwood R; Graham DA; McDowell S
[Ad] Address:Agri-Food and Biosciences Institute, Veterinary Science Division, Stormont, Belfast BT43SD, United Kingdom; School of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom. Electronic address: andrew.byrne@afbini.gov.uk.
[Ti] Title:Assessment of concurrent infection with bovine viral diarrhoea virus (BVDV) and Mycobacterium bovis: A herd-level risk factor analysis from Northern Ireland.
[So] Source:Prev Vet Med;141:38-47, 2017 Jun 01.
[Is] ISSN:1873-1716
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Bovine viral diarrhoea virus (BVDV) is a significant pathogen of cattle, leading to severe economic and animal-welfare impacts. Furthermore, the pathogen has been associated with impacting the progression or spread of other pathogens (e.g. Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB)). During this study we investigated (i) risk factors for BVDV at a herd-level and (ii) whether there was any association between BVDV and herd-level bTB risk. The data for this study were gathered from a voluntary BVDV control programme in Northern Ireland (2013-2015) based on the identification of virus positive animals through tissue tag testing of calves. We assigned a herd-level BVDV status to 2827 participating herds, where a herd was assumed "infected" if one or more animals tested positive for BVDV. Two model suites were developed. Firstly, we assessed risk factors for BVDV herd status using multivariable logit random-effects modelling, aggregating to the calendar year level (2013-2015; n=4828; model 1). Secondly, we aggregated data across the three years of the study to give an overall status for the whole study period (n=2827; logistic model 2). Risk factors included year, herd-type, herd size, number of births, inward trade moves, calf mortality, and region. Furthermore, the herd-level bovine tuberculosis status (based on the single intradermal comparative cervical tuberculin (SICCT) test outcomes, or confirmation at post-mortem), or the size of bTB breakdowns (number of SICCT test positive animals), of herds was also investigated to assess whether there was an association (co-infection) with herd BVDV status. The final models suggested that BVDV herd status was positively associated with increased levels of calf mortality, herd size, number of births, the number of BVDV tests undertaken and the number of animals introduced to the herd. There was a significant univariable positive association between BVDV status, and SICCT breakdown risk, breakdown size and confirmed bTB status in model 2. However, there was no evidence of significant associations between bTB status (using SICTT status, confirmed status or herd breakdown size) and BVDV status in final multivariable models when controlling for other significant confounders. These results provide information for action for the future control and eradication of BVDV in Northern Ireland, though these data provide little support for the hypothesised association between BVDV and bTB status at herd-level. Further animal-level analyses are necessary to investigate whether there is support for a BVD-bTB co-infection association, including the impact of co-infection on the severity of infection.
[Mh] MeSH terms primary: Bovine Virus Diarrhea-Mucosal Disease/complications
Cattle Diseases
Coinfection/veterinary
Tuberculosis, Bovine/complications
[Mh] MeSH terms secundary: Animals
Cattle
Cattle Diseases/microbiology
Cattle Diseases/virology
Coinfection/microbiology
Coinfection/virology
Dairying
Diarrhea Viruses, Bovine Viral
Female
Ireland
Male
Mycobacterium bovis
Risk Factors
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170926
[Lr] Last revision date:170926
[Js] Journal subset:IM
[Da] Date of entry for processing:170524
[St] Status:MEDLINE

  10 / 709 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 28474402
[Au] Autor:Gmez-Romero N; Basurto-Alcntara FJ; Verdugo-Rodrguez A; Lagunes-Quintanilla R; Bauermann FV; Ridpath JF
[Ad] Address:Laboratorio de Vacunologa y Constatacin, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autnoma de Mxico (UNAM), Ciudad de Mxico, Mxico.
[Ti] Title:Detection of border disease virus in Mexican cattle.
[So] Source:Transbound Emerg Dis;, 2017 May 04.
[Is] ISSN:1865-1682
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The genus Pestivirus within Flaviviridae is comprised of four recognized species, namely, bovine viral diarrhoea virus 1 (BVDV-1), bovine viral diarrhoea virus 2 (BVDV-2), border disease virus (BDV) and classical swine fever virus (CSFV). BDV, while primarily infecting sheep and goats, has also been reported in cattle and wild animals. Infections of sheep and goats result in economic loss due to abortions and the birth of persistently infected animals that have poor production and reduced life expectancy. In this study, we report the detection of BDV in cattle serum collected as part of pestivirus surveillance programme from six regions of Mexico, where a 67.1% of BVDV seroprevalence was calculated previously. Phylogenetic analyses based on comparison of the 5'UTR region typed the Mexican strains as BDV-1. Border disease (BD) is listed as an exotic disease in Mexico, and the origin of BDV found in these cattle is unclear. This is the first identification of BDV in Mexican cattle.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170505
[Lr] Last revision date:170505
[St] Status:Publisher
[do] DOI:10.1111/tbed.12641


page 1 of 71 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information