Database : MEDLINE
Search on : pharyngitis [Words]
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[PMID]: 29452197
[Au] Autor:Wijesundara NM; Rupasinghe HPV
[Ad] Address:Department of Biology, Faculty of Science, Dalhousie University, Halifax, NS, Canada; Department of Animal Science, Faculty of Animal Science and Export Agriculture, Uva Wellassa University, Badulla, Sri Lanka.
[Ti] Title:Essential oils from Origanum vulgare and Salvia officinalis exhibit antibacterial and anti-biofilm activities against Streptococcus pyogenes.
[So] Source:Microb Pathog;117:118-127, 2018 Feb 13.
[Is] ISSN:1096-1208
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In the present study, essential oils (EOs) extracted from oregano, sage, cloves, and ginger were evaluated for the phytochemical profile, antibacterial, and anti-biofilm activities against Streptococcus pyogenes. The broth microdilution method was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of EOs. The minimum biofilm inhibitory concentrations (MBICs) were determined using MTT assay and fixed biofilms were observed through scan electron microscopy. The oregano and sage EOs showed the lowest MIC as well as MBC of 0.25-0.5 mg/mL. Time kill assay results showed that oregano and sage EOs exhibited bactericidal effects within 5 min and 4 h, respectively. Both oregano and sage extracts acts as a potent anti-biofilm agent with dual actions, preventing and eradicating the biofilm. The microscopic visualization of biofilms treated with EOs have shown morphological and density changes compared to the untreated control. Oregano EO was constituted predominantly carvacrol (91.6%) and in sage EO, higher levels of α-thujone (28.5%) and camphor (16.6%) were revealed. EOs of oregano and sage inhibit the growth and biofilm formation of S. pyogenes. Effective concentrations of oregano and sage EOs and their phytochemicals can be used in developing potential plant-derived antimicrobial agents in the management of streptococcal pharyngitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 9138 MEDLINE  
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[PMID]: 29523424
[Au] Autor:Gottlieb M; Long B; Koyfman A
[Ad] Address:Department of Emergency Medicine, Rush University Medical Center, Chicago, Illinois.
[Ti] Title:Clinical Mimics: An Emergency Medicine-Focused Review of Streptococcal Pharyngitis Mimics.
[So] Source:J Emerg Med;, 2018 Mar 06.
[Is] ISSN:0736-4679
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Pharyngitis is a common disease in the emergency department (ED). Despite a relatively low incidence of complications, there are many dangerous conditions that can mimic this disease and are essential for the emergency physician to consider. OBJECTIVE: This article provides a review of the evaluation and management of group A -hemolytic Streptococcal (GABHS) pharyngitis, as well as important medical conditions that can mimic this disease. DISCUSSION: GABHS pharyngitis often presents with fever, sore throat, tonsillar exudates, and anterior cervical lymphadenopathy. History and physical examination are insufficient for the diagnosis. The Centor criteria or McIsaac score can help risk stratify patients for subsequent testing or treatment. Antibiotics may reduce symptom duration and suppurative complications, but the effect is small. Rheumatic fever is uncommon in developed countries, and shared decision making is recommended if antibiotics are used for this indication. Oral analgesics and topical anesthetics are important for symptom management. Physicians should consider alternate diagnoses that maymimic GABHS pharyngitis, which can include epiglottitis, infectious mononucleosis, Kawasaki disease, acute retroviral syndrome, Lemierre's syndrome, Ludwig's angina, peritonsillar abscess, retropharyngeal abscess, andviral pharyngitis. A focused history and physical examination can help differentiate these conditions. CONCLUSIONS: GABHS may present similarly to other benign and potentially deadly diseases. Diagnosis and treatment of pharyngitis should be based on clinical evaluation. Consideration of pharyngitis mimics is important in the evaluation and management of ED patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 9138 MEDLINE  
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[PMID]: 29446298
[Au] Autor:Katamanova EV; Dyakovich MP; Kudaeva IV; Shevchenko OI; Eshchina IM; Rukavishnikov VS; Meshchakova NM
[Ti] Title:[Clinical and neurophysiological peculiarities of health disorders in workers in dependence on the vinyl chloride exposure load].
[So] Source:Gig Sanit;95(12):1167-71, 2016.
[Is] ISSN:0016-9900
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Results of the clinical and neurophysiological examinations of 42 workers with operating history at the chemical plant exposed to vinyl chloride (VC) are presented. The purpose of research was the identification ofpeculiarities of clinical manifestations and disorders of the functional activity of the brain in workers at the vinyl chloride production, with taking into account the exposure toxic load (ETL). There were made clinical and electroencephalographic examinations with the detection of cognitive evoked potentials (CEP) and statistical analysis of results with the use of the Mann-Whitney U-test, Fisher's F-test, calculation of Spearman's correlation coefficient. The features in clinical picture of the pathology of the nervous system were detected in the form of asthenic disorders with cognitive impairment and autonomic dysfunction syndrome. There was established the increase in the cognitive impairment rate (p = 0.03), the decline in a-EEG activity (p = 0.01) and the worsening of indices of the amplitude (p = 0.011) and latency (p = 0,05) of CEP in extremely high level of ETL in comparison with same indices in the group with moderately high ETL. In the first group there was revealed a statistically significant exceedance of the frequency of hypertension - by 1.6 times, skin diseases - by 9 times, chronic subatrophic rhino-pharyngitis by 1.4 times in comparison with cases from the second group. In the group with moderately high level of ETL there was established the statistically significant inverse correlationship between the ETL and the index of P300 amplitude from the left side (r = -0.38, p = 0.019) and in the group with extremely high level ETL - between ETL and index of the 2 - rhythm (r = - 0.73, p = 0.0008).
[Mh] MeSH terms primary: Air Pollutants, Occupational
Manufacturing Industry
Neurotoxicity Syndromes
Vinyl Chloride
[Mh] MeSH terms secundary: Air Pollutants, Occupational/analysis
Air Pollutants, Occupational/toxicity
Electroencephalography/methods
Humans
Male
Manufacturing Industry/methods
Manufacturing Industry/standards
Middle Aged
Neurotoxicity Syndromes/diagnosis
Neurotoxicity Syndromes/epidemiology
Neurotoxicity Syndromes/etiology
Neurotoxicity Syndromes/physiopathology
Occupational Exposure/adverse effects
Occupational Exposure/analysis
Occupational Exposure/prevention & control
Risk Assessment/methods
Risk Assessment/statistics & numerical data
Risk Factors
Siberia/epidemiology
Time Factors
Vinyl Chloride/analysis
Vinyl Chloride/toxicity
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Air Pollutants, Occupational); WD06X94M2D (Vinyl Chloride)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180216
[St] Status:MEDLINE

  4 / 9138 MEDLINE  
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[PMID]: 29517940
[Au] Autor:Nishiyama M; Morioka I; Taniguchi-Ikeda M; Mori T; Tomioka K; Nakanishi K; Fujimura J; Nishimura N; Nozu K; Nagase H; Ishibashi K; Ishida A; Iijima K
[Ad] Address:1 Department of Paediatrics, 236610 Kobe University Graduate School of Medicine , Kobe, Japan.
[Ti] Title:Clinical features predicting group A streptococcal pharyngitis in a Japanese paediatric primary emergency medical centre.
[So] Source:J Int Med Res;:300060517752954, 2018 Jan 01.
[Is] ISSN:1473-2300
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Objectives To identify clinical features that predict Group A streptococcal (GAS) pharyngitis in a Japanese paediatric primary emergency medical centre. Methods The prevalence of GAS pharyngitis according to age and body temperature (BT) was calculated among 3098 paediatric patients with pharyngitis. The numbers of GAS-positive and -negative patients for each clinical parameter, and each point increase in the McIsaac score were compared and likelihood ratios (LRs) were calculated. Results The prevalence of GAS pharyngitis was extremely low in patients aged < 1 (1.2%) and 1 year (3.9%). The GAS-positive rate was significantly higher in patients with a BT < 38.0C compared with ≥ 38.0C (30.0% vs. 19.8%). A BT ≥ 38.0C was not a predictive finding for GAS pharyngitis (positive LR: 0.82). Rash was the most useful individual predictor, and a McIsaac score of 4 or 5 increased the probability; however, the positive LRs were 1.74 and 1.30, respectively. Conclusions The prevalence of GAS pharyngitis is extremely low in patients aged < 1 and 1 year, and a BT ≥ 38.0C is not a predictive symptom. Although a rash and McIsaac score of 4 or 5 are associated with an increased probability, they cannot be used to confirm GAS infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1177/0300060517752954

  5 / 9138 MEDLINE  
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[PMID]: 29317082
[Au] Autor:Beddar Chaib F; Mostaza Gallar P; Rodrguez Adrada E; Gonzlez Del Castillo J
[Ad] Address:Centro de Salud de Las guilas, Madrid, Espaa.
[Ti] Title:Ahorro de antibiticos prescritos en faringitis e infecciones del tracto respiratorio inferior en Atencin Primaria. [Saving antibiotics prescribed in pharyngitis and lower respiratory tract infections in Primary Care].
[So] Source:Aten Primaria;50(3):197-198, 2018 Mar.
[Is] ISSN:1578-1275
[Cp] Country of publication:Spain
[La] Language:spa
[Pt] Publication type:LETTER
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

  6 / 9138 MEDLINE  
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SciELO Brazil full text

[PMID]: 29267506
[Au] Autor:Zhang ZJ; Zheng ML; Nie Y; Niu ZQ
[Ad] Address:Department of Anesthesiology, the Cangzhou Central Hospital, Cangzhou, Hebei, China.
[Ti] Title:Comparison of Arndt-endobronchial blocker plus laryngeal mask airway with left-sided double-lumen endobronchial tube in one-lung ventilation in thoracic surgery in the morbidly obese.
[So] Source:Braz J Med Biol Res;51(2):e6825, 2017 Dec 18.
[Is] ISSN:1414-431X
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:This study aimed to evaluate the feasibility and performance of Arndt-endobronchial blocker (Arndt) combined with laryngeal mask airway (LMA) compared with left-sided double-lumen endobronchial tube (L-DLT) in morbidly obese patients in one-lung ventilation (OLV). In a prospective, randomized double-blind controlled clinical trial, 80 morbidly obese patients (ASA I-III, aged 20-70) undergoing general anesthesia for elective thoracic surgeries were randomly allocated into groups Arndt (n=40) and L-DLT (n=40). In group Arndt, a LMA™ Proseal was placed followed by an Arndt-endobronchial blocker. In group L-DLT, patients were intubated with a left-sided double-lumen endotracheal tube. Primary endpoints were the airway establishment, ease of insertion, oxygenation, lung collapse and surgical field exposure. Results showed similar ease of airway establishment and tube/device insertion between the two groups. Oxygen arterial pressure (PaO2) of patients in the Arndt group was significantly higher than L-DLT (15446 vs 10552 mmHg; P<0.05). Quality of lung collapse and surgical field exposure in the Arndt group was significantly better than L-DLT (effective rate 100 vs 90%; P<0.05). Duration of surgery and anesthesia were significantly shorter in the Arndt group (2.41.7 vs 3.11.8 and 2.81.9 vs 3.81.8 h, respectively; P<0.05). Incidence of hoarseness of voice and incidence and severity of throat pain at the post-anesthesia care unit and 12, 24, 48, and 72 h after surgery were significantly lower in the Arndt group (P<0.05). Findings suggested that Arndt-endobronchial blocker combined with LMA can serve as a promising alternative for morbidly obese patients in OLV in thoracic surgery.
[Mh] MeSH terms primary: Intubation, Intratracheal/instrumentation
Laryngeal Masks/standards
Obesity, Morbid/surgery
One-Lung Ventilation/instrumentation
Thoracic Surgical Procedures/instrumentation
[Mh] MeSH terms secundary: Adult
Aged
Double-Blind Method
Equipment Design
Female
Humans
Intubation, Intratracheal/methods
Male
Middle Aged
One-Lung Ventilation/methods
Operative Time
Pain, Postoperative/etiology
Pharyngitis/etiology
Prospective Studies
Pulmonary Atelectasis
Reproducibility of Results
Thoracic Surgical Procedures/methods
Time Factors
Treatment Outcome
Ventilators, Mechanical/standards
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171222
[St] Status:MEDLINE

  7 / 9138 MEDLINE  
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Marchi, Evaldo
SciELO Brazil full text

[PMID]: 29412428
[Au] Autor:Passos SD; Maziero FF; Antoniassi DQ; Souza LT; Felix AF; Dotta E; Orensztejn ME; Marchi E; Gazeta RE
[Ad] Address:Faculdade de Medicina de Jundia (FMJ), Jundia, SP, Brasil.
[Ti] Title:DOENAS RESPIRATRIAS AGUDAS EM CRIANAS BRASILEIRAS: OS CUIDADORES SO CAPAZES DE DETECTAR OS PRIMEIROS SINAIS DE ALERTA? ACUTE RESPIRATORY DISEASES IN BRAZILIAN CHILDREN: ARE CAREGIVERS ABLE TO DETECT EARLY WARNING SIGNS?
[So] Source:Rev Paul Pediatr;36(1):7, 2018 Jan-Mar.
[Is] ISSN:1984-0462
[Cp] Country of publication:Brazil
[La] Language:eng; por
[Ab] Abstract:OBJECTIVE: To assess the level of caregiver knowledge about respiratory signs and symptoms of acute respiratory infection (ARI) as well as their ability to detect the early warning signs and need for medical assistance in children referred to an emergency service. METHODS: This is a prospective, cross-sectional study. A standardized questionnaire with questions on the perception of the severity of ARI signs and symptoms was applied to caregivers of pediatric patients assisted in the emergency room of a university hospital from August 2011 to May 2012. Chi-square and Student's t-tests were used to determine which variables contributed with caregivers' recognition of severity of acute respiratory diseases. RESULTS: 499 caregivers were interviewed. The most cited causes of ARI were flu syndrome (78.6%), common cold (73.9%), pharyngitis (64.1%), and pneumonia (54.5%). Fever (34.1%) and cough (15.8%) were major reasons for referral to hospital. The most cited signs of severity recognized by caregivers were fever (99.6%), dyspnea (91.4%), wheezing (86.4%), adynamia (80.2%), coughing (79.8%), and tachypnea (78.6%). Children's history of respiratory diseases (p=0.002), caregiver's age (p=0.010) and marital status (p=0.014) were significantly associated with tachypnea, the most severe ARI symptom. CONCLUSIONS: Although caregivers of children can recognize ARI most important signs and symptoms, they are unable to judge severity, which may delay medical care and early treatment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process

  8 / 9138 MEDLINE  
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[PMID]: 29228130
[Au] Autor:Crowell TA; Colby DJ; Pinyakorn S; Fletcher JLK; Kroon E; Schuetz A; Krebs SJ; Slike BM; Leyre L; Chomont N; Jagodzinski LL; Sereti I; Utay NS; Dewar R; Rerknimitr R; Chomchey N; Trichavaroj R; Valcour VG; Spudich S; Michael NL; Robb ML; Phanuphak N; Ananworanich J; RV254/SEARCH010 Study Group
[Ad] Address:U.S. Military HIV Research Program, Walter Reed Army Institute of Research, USA.
[Ti] Title:Acute Retroviral Syndrome is Associated with High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments.
[So] Source:Clin Infect Dis;, 2017 Dec 07.
[Is] ISSN:1537-6591
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Background: Many individuals with acute HIV infection (AHI) experience acute retroviral syndrome (ARS), which is associated with adverse long-term clinical outcomes. We characterized clinical, virologic, and immunologic features of ARS and described the impact of early antiretroviral therapy (ART) initiation. Methods: Participants presenting for voluntary HIV testing were enrolled during AHI in Bangkok, Thailand. ARS was defined by ≥3 qualifying signs/symptoms. HIV burden, immunophenotypes, and biomarkers were stratified by ARS diagnosis at enrollment and after up to 96 weeks of ART. Results: From 212,382 samples screened, 430 participants were enrolled during AHI, including 335 (78%) with ARS. Median age was 26 years and 416 (97%) were men. Sixty (14%) underwent sigmoid biopsy and 105 (24%) underwent lumbar puncture during AHI. Common symptoms included fever (93%), fatigue (79%), pharyngitis (67%) and headache (64%). Compared to those without ARS, participants with ARS were in later Fiebig stages with higher HIV RNA in blood, colon, and cerebrospinal fluid; higher total HIV DNA in blood; CD4 depletion in blood and colon; and elevated plasma TNFα, C-reactive protein, and D-dimer (all p-values <0.05). Subgroup analyses of Fiebig I/II participants (95 with ARS, 69 without) demonstrated similar findings. After 96 weeks of ART, TNFα and IL-6 were elevated in the ARS group (p-values <0.05) but other biomarkers equilibrated. Conclusions: ARS was associated with high viral burden, CD4 depletion and immune activation across multiple body compartments during AHI and prior to ART. Persistent inflammation despite suppressive ART could contribute to increased morbidity in individuals who experience ARS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1093/cid/cix1063

  9 / 9138 MEDLINE  
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[PMID]: 29305544
[Au] Autor:Church DL; Lloyd T; Larios O; Gregson DB
[Ad] Address:Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada Deirdre.church@cls.ab.ca.
[Ti] Title:Evaluation of Simplexa Group A Strep Direct Kit Compared to Hologic Group A Streptococcal Direct Assay for Detection of Group A Streptococcus in Throat Swabs.
[So] Source:J Clin Microbiol;56(3), 2018 Mar.
[Is] ISSN:1098-660X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Diagnosis of bacterial pharyngitis is confirmed by detection of group A (GAS) in patient throat samples. Testing of throat samples has historically relied on culture, but new molecular methods allow much faster test turnaround time (i.e., same day versus 48 to 72 h for culture). Our laboratory uses the Hologic GAS Direct (GASD) assay for screening more than 125,000 throat samples per year. Simplexa GAS Direct is a new real-time quantitative PCR (qPCR) assay that does not require initial DNA extraction. Performance of Simplexa qPCR was compared to GASD. A total of 289 throat swabs were collected from patients attending ambulatory clinics in Calgary, Alberta, Canada. A total of 60 (20.8%) of the samples were initially GAS positive by either method: 54 by both methods, 4 by Simplex qPCR alone, and 2 by GASD alone. An in-house PCR using a unique GAS primer set was used to resolve the 6 discrepant results. Overall, GASD compared to Simplexa qPCR had a sensitivity, specificity, positive predictive value, and negative predictive value of 93.1% versus 100%, 100% versus 100%, 100% versus 100%, and 98.31% versus 100%, respectively. Implementation of Simplexa qPCR in our laboratory setting would cost more but allow the high sample volume to be reported in half the time and save 0.62 medical laboratory technician (MLT) full-time equivalent (FTE). In comparison to culture, the implementation of Simplexa qPCR would save 2.79 medical laboratory assistant (MLA) FTE plus 0.94 MLT FTE. Simplexa qPCR has improved performance and diagnostic efficiency in a high-volume laboratory compared to GASD for GAS detection in throat swabs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

  10 / 9138 MEDLINE  
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[PMID]: 29305539
[Au] Autor:Berry GJ; Miller CR; Prats MM; Marquez C; Oladipo OO; Loeffelholz MJ; Petersen JR
[Ad] Address:Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA gberry1@northwell.edu.
[Ti] Title:Comparison of the Alere i Strep A Test and the BD Veritor System in the Detection of Group A Streptococcus and the Hypothetical Impact of Results on Antibiotic Utilization.
[So] Source:J Clin Microbiol;56(3), 2018 Mar.
[Is] ISSN:1098-660X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Rapid detection of group A (GAS) is an integral component of treatment decisions in the clinic, especially in the pediatric population. We prospectively collected 216 specimens from symptomatic, predominantly pediatric patients and evaluated the performance of the Alere i Strep A test (Alere i; Alere Inc., Scarborough, ME) and the BD Veritor system (BD Veritor; Becton, Dickinson and Company, Sparks, MD), with culture results being used as a comparator. Real-time PCR (RT-PCR) was performed as an arbiter in discordant cases. Comprehensive chart review was also done to determine the hypothetical impact of the results on antibiotic use. Alere i had a sensitivity and a specificity of 100% and 91.3%, respectively, and BD Veritor had a sensitivity and a specificity of 76.2% and 93.6%, respectively, when the results were compared to those of GAS culture. Further analysis of discordant results using RT-PCR revealed that while BD Veritor missed 13 confirmed positive cases, Alere i detected 100% ( = 13) of the same cases. Analysis of assay agreement showed that Alere i and BD Veritor had only moderate agreement (agreement = 0.888 [95% confidence interval {CI}, 0.838 to 0.927]; kappa index = 0.689 [95% CI, 0.91 to 0.974]). We also found both the underutilization and the overutilization of antibiotics based on the results of molecular testing. Overall, Alere i showed superior performance over BD Veritor in the detection of GAS pharyngitis and could potentially assist in better antibiotic utilization.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review


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