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[PMID]: 29524920
[Au] Autor:Sakhi AK; Sabaredzovic A; Papadopoulou E; Cequier E; Thomsen C
[Ad] Address:Department of Environmental Exposure and Epidemiology, Division of Infection Control, Environment and Health, Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, 0403 Oslo, Norway. Electronic address: amritkaur.sakhi@fhi.no.
[Ti] Title:Levels, variability and determinants of environmental phenols in pairs of Norwegian mothers and children.
[So] Source:Environ Int;114:242-251, 2018 Mar 07.
[Is] ISSN:1873-6750
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Exposure to environmental phenols including parabens, bisphenols (BPs), oxybenzone/benzophenone-3 (BP-3) and triclosan (TCS) is ubiquitous. Due to evidence of their estrogenic activity, they have been considered as chemicals of concern. The exposure of the Norwegian population to these compounds is presently unknown. AIMS: To measure urinary levels of twelve different environmental phenols including four emerging bisphenols: S, F, B and AF (abbreviated as BPS, BPF, BPB and BPAF, respectively) in a healthy Norwegian population. We have calculated short-term variability, estimated daily intakes and investigated important determinants of exposure. METHODS: Urine samples were collected from mothers (n = 48) and their children (n = 56) during spring/summer 2012 in two counties in Norway. RESULTS: Six environmental phenols namely methyl, ethyl and propyl paraben, BPA, BP-3 and TCS were detected in almost 100% of the urine samples. Among the emerging bisphenols, BPS was detected most frequently in the urine samples (42-48%) followed by BPF (4-15%). Parabens were positively and significantly correlated to each other in both mothers and children. Levels of parabens and BP-3 were higher in mothers compared to children. All mothers and children had lower estimated daily intakes (back calculated from the urinary concentrations) of parabens and BPA than the respective acceptable and tolerable daily intakes (ADIs and TDIs) established by the European Food Safety Authority (EFSA). Observed intraclass correlation coefficients (ICCs) indicated moderate to high reliability of spot urine measurements for all the environmental phenols (ICCs: 0.70-0.97). Use of hair products, deodorants, face and hand creams were significantly associated with higher urinary levels of parabens. CONCLUSIONS: Occurrence of environmental phenols in healthy Norwegian women and children is abundant. Among emerging bisphenols, there is widespread exposure to BPS. A single spot urine sample can be used for estimating short-term exposures of environmental phenols. Urinary levels of parabens were associated with use of PCPs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 58999 MEDLINE  
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[PMID]: 29524800
[Au] Autor:Horikoshi HM; Sekozawa Y; Kobayashi M; Saito K; Kusano M; Sugaya S
[Ad] Address:Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: humberto_hmh@hotmail.com.
[Ti] Title:Metabolomics analysis of 'Housui' Japanese pear flower buds during endodormancy reveals metabolic suppression by thermal fluctuation.
[So] Source:Plant Physiol Biochem;126:134-141, 2018 Mar 02.
[Is] ISSN:1873-2690
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Dormancy is a complex phenomenon that allows plants to survive the winter season. Studies of dormancy have recently attracted more attention due to the expansion of temperate fruit production in areas under mild winters and due to climate changes. This study aimed to identify and characterize the metabolic changes induced by chilling temperatures, as well as during thermal fluctuation conditions that simulate mild winter and/or climate change scenarios. To do this, we compared the metabolic profile of Japanese pear flower buds exposed to constant chilling at 6 C and thermal fluctuations of 6 C/18 C (150 h/150 h) during endodormancy. We detected 91 metabolites by gas chromatography paired with time-of-flight mass spectrometry (GC-TOF-MS) that could be classified into eight groups: amino acids, amino acid derivatives, organic acids, sugars and polyols, fatty acids and sterols, phenol lipids, phenylpropanoids, and other compounds. Metabolomics analysis revealed that the level of several amino acids decreased during endodormancy. Sugar and polyol levels increased during endodormancy during constant chilling and might be associated with chilling stress tolerance and providing an energy supply for resuming growth. In contrast, thermal fluctuations produced low levels of metabolites related to the pentose phosphate pathway, energy production, and tricarboxylic acid (TCA) cycle in flower buds, which may be associated with failed endodormancy release. This metabolic profile contributes to our understanding of the biological mechanism of dormancy during chilling accumulation and clarifies the metabolic changes during mild winters and future climate change scenarios.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 58999 MEDLINE  
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[PMID]: 29522653
[Au] Autor:Wnsch B; Szermerski M; Brgel F; Schepmann D; Betzel T; Ametamey S; Haider A
[Ad] Address:University of Muenster, Department of Pharmaceutical and Medicinal Chemistry, Corrensstrae 48, 48149, Mnster, GERMANY.
[Ti] Title:Fluorinated GluN2B receptor antagonists with a 3-benzazepine scaffold designed for PET studies.
[So] Source:ChemMedChem;, 2018 Mar 09.
[Is] ISSN:1860-7187
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:In order to analyze the NMDA receptor distribution in the central nervous system, fluorinated ligands selectively addressing the ifenprodil binding site of GluN2B subunit containing NMDA receptors were developed. Various strategies to introduce a fluorine atom into the potent GluN2B ligand 2 were pursued including the replacement of the benzylic OH moiety by a F-atom (13) and introduction of fluoroethoxy moieties at different positions (14, 17 18a-c). With respect to GluN2B affinity and selectivity over related receptors, the fluoroethoxy derivatives 14 and 18a represent the most promising ligands. Radiosynthesis of fluoroethoxy derivative [18F]14 was performed by nucleophilic substitution of the phenol 12c with 2-[18F]fluoroethyl tosylate. On rat brain slices the fluorinated PET tracer [18F]14 accumulated in regions with high density of NMDA receptors containing GluN2B subunits. The bound radioactivity could not be replaced by (S)-glutamate. However, the GluN2B ligands eliprodil, Ro 25-6981 and the non-labeled 3-benzazepine 14 were able to abolish the specific binding of [18F]14.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1002/cmdc.201700819

  4 / 58999 MEDLINE  
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[PMID]: 28465179
[Au] Autor:Mullaivanam Ramasamy S; Denis M; Sivakumar S; Munusamy A
[Ad] Address:Laboratory of Pathobiology, Department of Zoology, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India. Electronic address: sivakumarmr1981@gmail.com.
[Ti] Title:Phenoloxidase activity in humoral plasma, hemocyanin and hemocyanin separated proteins of the giant freshwater prawn Macrobrachium rosenbergii.
[So] Source:Int J Biol Macromol;102:977-985, 2017 Sep.
[Is] ISSN:1879-0003
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Hemocyanin is a copper containing protein and its role in the immune function of phenoloxidase (PO) activity was investigated in the giant freshwater prawn Macrobrachium rosenbergii. Hemocyanin, sedimented by ultracentrifugation from the plasma appeared on polyacrylamide gel electrophoresis (PAGE 7%) on Coomassie Brilliant Blue and bathocuproine sulfonic acid stain as four copper containing proteins of molecular masses 50, 60, 114 and 325kDa. Accordingly, on diethylaminoethyl-cellulose anion exchange column hemocyanin separated into four proteins designated as MrHc1, MrHc2, MrHc3 and MrHc4 with electrophoretically (PAGE) determined molecular masses of 60, 114, 50 and 325kDa respectively. The reduction of proteins in sodium dodecyl sulphate (SDS)-PAGE revealed that MrHc1 and 3 were monomeric for 60and 50kDa respectively, MrHc2 dimeric of 56 and 58kDa subunits and MrHc4 appeared with three subunits of 74, 76 and 78kDa. The PO activity was determined in plasma, hemocyanin and the four separated hemocyanin proteins in vitro using L-3,4-dihydroxyphenylalanine (L-DOPA) at pH7.5, 25C and appeared elicited by exogenous activators such as trypsin, SDS, cell wall components of bacteria and polysaccharide laminarin. This study clearly demonstrated hemocyanin as the major copper containing protein in the plasma of M. rosenbergii with potent PO activity.
[Mh] MeSH terms primary: Hemocyanins/metabolism
Immunity, Humoral
Monophenol Monooxygenase/blood
Monophenol Monooxygenase/metabolism
Palaemonidae/enzymology
[Mh] MeSH terms secundary: Animals
Palaemonidae/immunology
Palaemonidae/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:9013-72-3 (Hemocyanins); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:170504
[St] Status:MEDLINE

  5 / 58999 MEDLINE  
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[PMID]: 29520881
[Au] Autor:Yen CH; Chiu HF; Huang SY; Lu YY; Han YC; Shen YC; Venkatakrishnan K; Wang CK
[Ad] Address:Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung City, Taiwan.
[Ti] Title:Beneficial effect of Burdock complex on asymptomatic Helicobacter pylori-infected subjects: A randomized, double-blind placebo-controlled clinical trial.
[So] Source:Helicobacter;, 2018 Mar 08.
[Is] ISSN:1523-5378
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Burdock complex (BC) constitutes of burdock (Arctium lappa), angelica (Angelica sinensis), gromwell (Lithospermum erythrorhizon), and sesame (Sesamumindicum) oil, which are commonly used in traditional Chinese medicine (TCM) for treating various disorders. This study intended to examine the anti-H.pyloriactivity of BC on AGS cell model as well as in asymptomatic H.pylori-infected subjects. MATERIALS AND METHODS: AGS cell incubated with H.pylori and treated with BC to evaluate the minimum inhibition concentration (MIC), cell viability (MTT) anti-adhesion activity, and inflammatory markers. In case of clinical trial, H.pylori-positive subjects (urea breath test [UBT] >10%, n=36) were enrolled and requested to intakeBC (n=19) or placebo (n=17) for 8weeks. Antioxidant capacity, total phenol, UBT, inflammatory markers were analyzed at the initial, 4th, 8th, and 10th weeks. Moreover, the endoscopic examination was carried out on baseline and 10th week. RESULTS: In vitro studies showed that BC treatment significantly inhibited (P<.05) the inflammatory markers and adhesion ofH.pylorito AGS cell. However, H.pylori-infected subject ingested with BC for 8weeks significantly decreased (P<.05) the UBT value, inflammatory markers with improved antioxidant activity, and phenolic levels as compared to placebo. Also, consumption of BC considerably healed the ulcer wound. CONCLUSION: Overall, the BC could attenuate H.pylori infection by inhibiting H.pylori adhesion and subsequent inflammatory response on the gastric epithelial cell (AGS) as well as clinically ameliorated UBT, antioxidant capacity, and alleviated inflammation to display its anti-H.pylori activity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/hel.12469

  6 / 58999 MEDLINE  
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[PMID]: 29518735
[Au] Autor:Xia L; Bai J; Li J; Li L; Chen S; Xu Q; Zhou B
[Ad] Address:School of Environmental Science and Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Shanghai 200240, PR China.
[Ti] Title:High-efficient energy recovery from organics degradation for neutral wastewater treatment based on radicals catalytic reaction of Fe /Fe -EDTA complexes.
[So] Source:Chemosphere;201:59-65, 2018 Feb 27.
[Is] ISSN:1879-1298
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A high-efficient photo-induced wastewater fuel cell (WFC) for neutral wastewater treatment was proposed in this paper based on radicals catalytic reaction of Fe /Fe - EDTA complexes in the system which has a lower redox potential than Fe /Fe and can accelerate easily the conversion of slow catalytic step from Fe (III) to Fe (II). The results indicated that the WFC shows an excellent performance in a wide pH range of 5-9 and achieves optimal efficiency for organic degradation and electricity generation at pH 7.0. The removal ratio of organic pollutants (Rhodamine b, Phenol, and Methylene Blue) increased to 69.42%, 53.99% and 82.7% from 29.87%, 16.25% and 39% respectively after 3 h operation at an initial pH of 7.0. Meanwhile, the short-circuit current is up to 1.24-2.16 times that of the WFC without EDTA-ferrous complex. Furthermore, the system almost does not produce any sludge. The proposed WFC system can keep stable of Fe /Fe in neutral solution and generate more intermediate active free radicals to treat neutral wastewater and recover the abundant chemical energy in organics.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher

  7 / 58999 MEDLINE  
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[PMID]: 29518654
[Au] Autor:Zhou H; Wang G; Wu M; Xu W; Zhang X; Liu L
[Ad] Address:Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Food and Environment, Dalian University of Technology, Panjin, 124221, China. Electronic address: zhouhao@dlut.edu.cn.
[Ti] Title:Phenol removal performance and microbial community shift during pH shock in a moving bed biofilm reactor (MBBR).
[So] Source:J Hazard Mater;351:71-79, 2018 Mar 05.
[Is] ISSN:1873-3336
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:A moving bed biofilm reactor (MBBR) effectively removes pollutants and even runs under extreme conditions. However, the pH shock resistance of a biofilm in MBBRs has been rarely reported. In this study, simulated phenol wastewater with acidic shock (pH 7.5-3.0) was used. In the pH shock phase, the phenol and COD removal efficiencies initially decreased and gradually increased to more than 90%. Microscopic studies showed that the superficial biofilm was mainly composed of fungi (yeasts) in the acidic pH shock phase. The microbial community composition in the acidic pH shock phase was significantly different from those in other phases. Firmicutes and Ascomycota were the dominant bacterial and fungal phyla in this stage, respectively. 16S rRNA gene-based functional annotation indicated that functional profiles related to aromatic compound degradation existed in all of the stages. Therefore, MBBRs show potential for the treatment of phenolic wastewater exposed to pH shock.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher

  8 / 58999 MEDLINE  
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[PMID]: 29518052
[Au] Autor:Ghosh M; Kim IS; Lee YM; Hong SM; Lee TH; Lim JH; Debnath T; Lim BO
[Ad] Address:Department of Applied Life Science, College of Biomedical & Health Science, Konkuk University, Chungju-si, Chungcheongbuk-do 27478, Korea. mithunghoshmg@gmail.com.
[Ti] Title:The Effects of Aronia melanocarpa 'Viking' Extracts in Attenuating RANKL-Induced Osteoclastic Differentiation by Inhibiting ROS Generation and c-FOS/NFATc1 Signaling.
[So] Source:Molecules;23(3), 2018 Mar 08.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:This study aimed to determine the anti-osteoclastogenic effects of extracts from 'Viking' (AM) and identify the underlying mechanisms in vitro. Reactive oxygen species (ROS) are signal mediators in osteoclast differentiation. AM extracts inhibited ROS production in RAW 264.7 cells in a dose-dependent manner and exhibited strong radical scavenging activity. The extracts also attenuated the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated osteoclasts. To attain molecular insights, the effect of the extracts on the signaling pathways induced by receptor activator of nuclear factor kappa B ligand (RANKL) were also investigated. RANKL triggers many transcription factors through the activation of mitogen-activated protein kinase (MAPK) and ROS, leading to the induction of osteoclast-specific genes. The extracts significantly suppressed RANKL-induced activation of MAPKs, such as extracellular signal-regulated kinase (ERK), c-Jun- -terminal kinase (JNK) and p38 and consequently led to the downregulation of c-Fos and nuclear factor of activated T cells 1 (NFATc1) protein expression which ultimately suppress the activation of the osteoclast-specific genes, cathepsin K, TRAP, calcitonin receptor and integrin 3. In conclusion, our findings suggest that AM extracts inhibited RANKL-induced osteoclast differentiation by downregulating ROS generation and inactivating JNK/ERK/p38, nuclear factor kappa B (NF-κB)-mediated c-Fos and NFATc1 signaling pathway.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process

  9 / 58999 MEDLINE  
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[PMID]: 29477955
[Au] Autor:Messerlian C; Mustieles V; Minguez-Alarcon L; Ford JB; Calafat AM; Souter I; Williams PL; Hauser R; Environment and Reproductive Health (EARTH) Study Team
[Ad] Address:Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: cmesser@hsph.harvard.edu.
[Ti] Title:Preconception and prenatal urinary concentrations of phenols and birth size of singleton infants born to mothers and fathers from the Environment and Reproductive Health (EARTH) study.
[So] Source:Environ Int;114:60-68, 2018 Feb 22.
[Is] ISSN:1873-6750
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Although pregnancy concentrations of some phenols have been associated with infant size at birth, there is limited data on the effect of preconception exposure. OBJECTIVE: We aimed to examine paternal and maternal preconception and maternal prenatal urinary phenol concentrations in relation to birth weight and head circumference. METHODS: We evaluated 346 singletons born to 346 mothers and 184 fathers (184 couples) from a prospective preconception cohort of subfertile couples from the Environment and Reproductive Health (EARTH) Study in Boston, USA. We used multiple urine samples collected before the index pregnancy in both men and women to estimate mean preconception urinary benzophenone-3, triclosan, butylparaben, propylparaben, methylparaben, or ethylparaben concentrations. We also estimated mean maternal prenatal urinary phenol concentrations by averaging trimester-specific urine samples. Birth weight and head circumference were abstracted from delivery records. We estimated the association of natural log-phenol concentrations with birth outcomes using multivariable linear regression models, adjusting for known confounders. RESULTS: In adjusted models, each log-unit increase in paternal preconception benzophenone-3 concentration was associated with a 137 g increase in birth weight (95% CI: 60, 214). Additional adjustment for prenatal benzophenone-3 concentration strengthened this association. None of the maternal preconception phenol concentrations were associated with birth weight. However, maternal prenatal triclosan concentrations were associated with a 38 g decrease in birth weight (95% CI: -76, 0). Few associations were observed between phenols and head circumference except for a decrease of 0.27 cm (95% CI: -54, 0) in relation to maternal preconception methylparaben concentration. CONCLUSIONS: Although our findings should be interpreted in light of inherent study limitations, these results suggest potential evidence of associations between some paternal or maternal phenol concentrations and birth size.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  10 / 58999 MEDLINE  
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[PMID]: 29397276
[Au] Autor:Beskin KV; Holcomb CD; Cammack JA; Crippen TL; Knap AH; Sweet ST; Tomberlin JK
[Ad] Address:Department of Entomology, Texas A&M University, 370 Olsen Boulevard, College Station, TX 77843, USA. Electronic address: Kelly.Beskin@gmail.com.
[Ti] Title:Larval digestion of different manure types by the black soldier fly (Diptera: Stratiomyidae) impacts associated volatile emissions.
[So] Source:Waste Manag;74:213-220, 2018 Apr.
[Is] ISSN:1879-2456
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Volatile emissions from decomposing animal waste are known environmental pollutants. The black soldier fly, Hermetia illucens (L.), is being evaluated for industrialization as a means to recycle wastes and produce protein for use as food and feed. We examined the ability of black soldier fly larvae to reduce odorous compounds associated with animal wastes. Black soldier fly larvae were reared under laboratory conditions on poultry, swine, and dairy manure at feed rates of 18.0 and 27.0 g every other day until 40% reached the prepupal stage. Volatile emissions were collected and analyzed from freshly thawed as well as the digested waste when 90% of the black soldier fly larvae reached the prepupal stage. Volatiles were also collected simultaneously from manure not inoculated with black soldier fly larvae (non-digested) and held under similar conditions. Manure samples were analyzed for relative amounts of nine select odorous volatile organic compounds: phenol, 4-methylphenol, indole, 3-methylindole, propanoic acid, 2-methylpropanoic acid, butanoic acid, 3-methylbutanoic acid and pentanoic acid. Black soldier fly larvae reduced emissions of all volatile organic compounds by 87% or greater. Complete reductions were observed for 2-methly propanoic acid in digested poultry manure, phenol, 4-methylphenol, indole and all five fatty acids in digested swine manure, and 4-methylphenol, indole, 3-methylindole and all five acids in digested dairy manure. This study is the first to identify volatile emissions from manure digested by black soldier fly larvae and compare to those found in non-digested manure. These data demonstrate additional benefits of using black soldier fly larvae as a cost-effective and environmentally friendly means of livestock manure management in comparison to current methods. CAPSULE: Black soldier fly larvae are capable of altering the overall profile of volatile organic compounds and reducing levels of targeted odorous compounds in livestock manure.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process


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