Database : MEDLINE
Search on : phosphorus and metabolism and disorders [Words]
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[PMID]: 29289451
[Au] Autor:Gramegna LL; Giannoccaro MP; Manners DN; Testa C; Zanigni S; Evangelisti S; Bianchini C; Oppi F; Poda R; Avoni P; Lodi R; Liguori R; Tonon C
[Ad] Address:Functional MR Unit, Policlinico S. Orsola-Malpighi, via Massarenti 9, 40138, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, via Ugo Foscolo 7, 40123, Bologna, Italy.
[Ti] Title:Mitochondrial dysfunction in myotonic dystrophy type 1.
[So] Source:Neuromuscul Disord;28(2):144-149, 2018 Feb.
[Is] ISSN:1873-2364
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The pathophysiological mechanism linking the nucleotide expansion in the DMPK gene to the clinical manifestations of myotonic dystrophy type 1 (DM1) is still unclear. In vitro studies demonstrate DMPK involvement in the redox homeostasis of cells and the mitochondrial dysfunction in DM1, but in vivo investigations of oxidative metabolism in skeletal muscle have provided ambiguous results and have never been performed in the brain. Twenty-five DM1 patients (14M, 39 ± 11years) underwent brain proton MR spectroscopy ( H-MRS), and sixteen cases (9M, 40 ± 13 years old) also calf muscle phosphorus MRS ( P-MRS). Findings were compared to those of sex- and age-matched controls. Eight DM1 patients showed pathological increase of brain lactate and, compared to those without, had larger lateral ventricles (p < 0.01), smaller gray matter volumes (p < 0.05) and higher white matter lesion load (p < 0.05). A reduction of phosphocreatine/inorganic phosphate (p < 0.001) at rest and, at first minute of exercise, a lower [phosphocreatine] (p = 0.003) and greater [ADP] (p = 0.004) were found in DM1 patients compared to controls. The post-exercise indices of muscle oxidative metabolism were all impaired in DM1, including the increase of time constant of phosphocreatine resynthesis (TC PCr, p = 0.038) and the reduction of the maximum rate of mitochondrial ATP synthesis (p = 0.033). TC PCr values correlated with the myotonic area score (ρ = 0.74, p = 0.01) indicating higher impairment of muscle oxidative metabolism in clinically more affected patients. Our findings provide clear in vivo evidence of multisystem impairment of oxidative metabolism in DM1 patients, providing a rationale for targeted treatment enhancing energy metabolism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180225
[Lr] Last revision date:180225
[St] Status:In-Data-Review

  2 / 1491 MEDLINE  
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[PMID]: 29280738
[Au] Autor:Acar S; Demir K; Shi Y
[Ad] Address:Dokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology, Izmir, Turkey.
[Ti] Title:Genetic Causes of Rickets.
[So] Source:J Clin Res Pediatr Endocrinol;9(Suppl 2):88-105, 2017 Dec 30.
[Is] ISSN:1308-5735
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:Rickets is a metabolic bone disease that develops as a result of inadequate mineralization of growing bone due to disruption of calcium, phosphorus and/or vitamin D metabolism. Nutritional rickets remains a significant child health problem in developing countries. In addition, several rare genetic causes of rickets have also been described, which can be divided into two groups. The first group consists of genetic disorders of vitamin D biosynthesis and action, such as vitamin D-dependent rickets type 1A (VDDR1A), vitamin D-dependent rickets type 1B (VDDR1B), vitamin D-dependent rickets type 2A (VDDR2A), and vitamin D-dependent rickets type 2B (VDDR2B). The second group involves genetic disorders of excessive renal phosphate loss (hereditary hypophosphatemic rickets) due to impairment in renal tubular phosphate reabsorption as a result of FGF23-related or FGF23-independent causes. In this review, we focus on clinical, laboratory and genetic characteristics of various types of hereditary rickets as well as differential diagnosis and treatment approaches.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180204
[Lr] Last revision date:180204
[St] Status:In-Process
[do] DOI:10.4274/jcrpe.2017.S008

  3 / 1491 MEDLINE  
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[PMID]: 29029099
[Au] Autor:Ishigami J; Jaar BG; Rebholz CM; Grams ME; Michos ED; Wolf M; Kovesdy CP; Uchida S; Coresh J; Lutsey PL; Matsushita K
[Ad] Address:Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
[Ti] Title:Biomarkers of Mineral and Bone Metabolism and 20-year Risk for Hospitalization with Infection: the ARIC Study.
[So] Source:J Clin Endocrinol Metab;, 2017 Sep 27.
[Is] ISSN:1945-7197
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Context: Mineral and bone disorders (MBD) may be relevant in the etiology of infection. Objective: To determine whether MBD biomarkers were associated with incidence of hospitalization with infection. We also assessed the cross-sectional association between levels of MBD biomarkers and kidney function. Design: Setting, Participants: Community-based cohort study using 11,218 participants with estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73m2 in the Atherosclerosis Risk in Communities study. We assessed the cross-sectional associations of five MBD markers (fibroblast growth factor 23 (FGF23), 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), calcium corrected for hypoalbuminemia, and phosphorus) with eGFR in 1990-1992, and their longitudinal associations with incident hospitalization with infection in 1990-2013. Main outcome: Incident hospitalization with infection. Results: In age-, sex-, and race-adjusted models, lower eGFR was significantly associated with higher levels of FGF23, PTH and corrected calcium, but not 25(OH)D or phosphorus. During follow-up, there were 5,078 hospitalizations with infection. In fully adjusted Cox models with the second quartile as the reference, the hazard ratio (HR) was significantly higher in the highest quartile of FGF23 (HR, 1.12 [95%CI, 1.03-1.21]; PTH (HR, 1.09 [95%CI, 1.01-1.18]) and corrected calcium (HR, 1.11 [95%CI, 1.03-1.20]); and the lowest quartile for 25(OH)D (HR, 1.11 [95%CI, 1.03-1.21]). The association with phosphorus was significant only when the outcome was restricted to persons with a primary diagnosis of infection. These findings were consistent across subgroups of age, sex, race, or eGFR (< vs. ≥60 ml/min/1.73m2). Conclusion: MBD biomarkers were associated with eGFR and subsequent risk of infection, supporting the involvement of MBD in the etiology of infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171013
[Lr] Last revision date:171013
[St] Status:Publisher
[do] DOI:10.1210/jc.2017-01868

  4 / 1491 MEDLINE  
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[PMID]: 28843391
[Au] Autor:Jean G; Daugas É; Roth H; Drueke T; Bouchet JL; Hannedouche T; London G; Fouque D
[Ad] Address:NephroCare Tassin-Charcot, 7, avenue du Maréchal-Foch, 69110 Sainte-Foy-lès-Lyon, France. Electronic address: guillaume-jean-crat@wanadoo.fr.
[Ti] Title:La prise en charge des troubles du métabolisme minéral et osseux avant le stade de la dialyse reste encore perfectible. À partir des données de l'Observatoire national du métabolisme minéral et osseux Photo-Graphe. [Management of bone and mineral metabolism disorders before the dialysis stage remains still perfectible. Data from the French Phosphorus and Calcium Survey Photo-Graphe].
[So] Source:Nephrol Ther;13(6):470-478, 2017 Nov.
[Is] ISSN:1872-9177
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:Only limited data is available on the management of the chronic kidney disease-associated bone and mineral metabolism disorder (CKD-MBD) in the pre-dialysis stages of CKD in France. A better knowledge of current management habits could lead to an improvement in the implementation of international recommendations (KDIGO). The 3rd version of the French Phosphorus and Calcium Survey Photo-Graphe (Sanofi) included a cohort of CKD stages 4 and 5 patients, whose aim was to examine the prevalence of CKD-MBD and the quality of its management in patients under the care of 62 nephrologists from over 20 geographical regions in France. The study started in October 2011, i.e. one year after patient enrollment. We examined in particular the percentage of patients presenting with laboratory parameter abnormalities indicative of CKD-MBD who were not receiving adequate treatment. A total of 456 patients with CKD stage 4 and 154 with CKD stage 5 were studied. Their mean age was 72.9±14.2 years, and male/female ratio was 58/42. KDIGO targets of serum PTH for CKD stages 4 and 5 were not achieved in respectively 80 and 84% of the patients, for serum calcium in 8 and 22% and for serum phosphate in 12 and 46%. As a potential explanation, insufficient therapy was estimated to account for respectively 45 and 60% of insufficiently controlled secondary hyperparathyroidism, and for 36% of persistent hyperphosphatemia in stage 5. It should be noted that 55.5 and 57.5% of patients were receiving native vitamin D. In this national observatory, the management of CKD-MBD stages 4 and 5 appears suboptimal, especially as regards the control of secondary hyperparathyroidism, which remained untreated in nearly 50% of the patients. Hyperphosphatemia was also common and inadequately controlled in CKD stage 5. To improve the management of CKD-MBD, nephrologists need to be more aware of the importance of aiming for recommended laboratory targets and how this can be achieved.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:In-Process

  5 / 1491 MEDLINE  
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[PMID]: 28808770
[Au] Autor:Chen Q; Zhang Y; Ding D; Li D; Yang Y; Li Q; Chen X; Hu G; Ling W
[Ad] Address:Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangdong, 510080, China.
[Ti] Title:Associations between serum calcium, phosphorus and mortality among patients with coronary heart disease.
[So] Source:Eur J Nutr;, 2017 Aug 14.
[Is] ISSN:1436-6215
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: Serum calcium and phosphorus abnormalities are associated with cardiovascular disorders in general population, but evidence among patients with established coronary heart disease (CHD) is limited and controversial. This study aimed to investigate the associations of baseline serum calcium and phosphorus levels with long-term mortality risk among patients with CHD. METHODS: We conducted a prospective cohort study among 3187 patients with CHD from October 2008 and December 2011 in China. Cox proportional hazards model was used to assess the associations of serum calcium and phosphorus at baseline with the risk of death. RESULTS: During follow-up (mean, 4.9 years), 295 patients died, 193 of which resulted from cardiovascular causes. Multivariable-adjusted hazard ratios (HR) for each 1 mmol/L increase in serum calcium at baseline were 0.27 (95% confidence interval (CI) 0.14-0.51) for all-cause mortality and 0.26 (95% CI 0.12-0.54) for cardiovascular mortality. Patients in the highest compared to the lowest quartile of serum calcium were at lower risk of all-cause mortality (HR, 95% CI 0.57, 0.40-0.82) and cardiovascular mortality (0.50, 0.32-0.79) (both P  < 0.001). This inverse association between serum calcium and the risk of mortality did not change when participants were stratified by sex, age groups, level of overweight, types of CHD, and history of diabetes. We also observed a graded positive association between baseline serum phosphorus and the risks of mortality. CONCLUSIONS: The present study is the first to report that lower serum calcium at baseline is associated with an increased risk of all-cause and cardiovascular mortality in a Chinese coronary heart disease cohort. Further studies are required to investigate the causal relationship and actual mechanisms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170815
[Lr] Last revision date:170815
[St] Status:Publisher
[do] DOI:10.1007/s00394-017-1518-8

  6 / 1491 MEDLINE  
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[PMID]: 28760231
[Au] Autor:Chew CK; Clarke BL
[Ad] Address:Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, E-18A, 200 1st Street Southwest, Rochester, MN 55905, USA.
[Ti] Title:Biochemical Testing Relevant to Bone.
[So] Source:Endocrinol Metab Clin North Am;46(3):649-667, 2017 Sep.
[Is] ISSN:1558-4410
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Laboratory biochemical testing is critical to the clinical understanding of bone disorders. Patients with skeletal diseases have underlying themes in their pathophysiology that would be impossible to detect without biochemical assessment of serum and urine minerals, vitamin D, parathyroid hormone, parathyroid hormone-related peptide, and bone turnover markers. Bone disorders are caused by abnormalities in signaling pathways that affect bone formation and resorption. Therapies for common bone diseases were developed in direct response to underlying biochemical abnormalities.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1708
[Cu] Class update date: 170801
[Lr] Last revision date:170801
[St] Status:In-Process

  7 / 1491 MEDLINE  
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[PMID]: 28736564
[Au] Autor:Verhulst A; Neven E; D'Haese PC
[Ad] Address:Laboratory of Pathophysiology, University of Antwerp, Antwerp, Belgium.
[Ti] Title:Characterization of an Animal Model to Study Risk Factors and New Therapies for the Cardiorenal Syndrome, a Major Health Issue in Our Aging Population.
[So] Source:Cardiorenal Med;7(3):234-244, 2017 Jun.
[Is] ISSN:1664-3828
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:BACKGROUND: The cardiorenal syndrome (CRS) is a major health problem in our aging population. The term was introduced to cover disorders of the kidneys and heart, whereby dysfunction of one organ may induce dysfunction of the other. As the natural history of the CRS is mostly slow, hence difficult to explore in clinical trials, adequate animal models combining cardiovascular and renal disease are required. Therefore, we developed and characterized a usable model for CRS type 4, i.e. chronic kidney disease (CKD) causing cardiac dysfunction. METHODS: CKD was induced in rats by supplementing the diet with adenine. During 8 weeks, several aspects of CRS were studied: CKD, mineral-bone disorder (MBD), cardiovascular disease, and (iron-deficiency) anemia. Hereto, the following parameters were monitored: serum creatinine, calcium, phosphate, FGF23, dynamic bone parameters, aortic Ca deposits, heart weight, serum NT-proANP, Hct, Hb, reticulocytes, spleen iron, and serum hepcidin. RESULTS: Animals developed a severe CKD together with a disturbed mineral balance as reflected by the increased serum creatinine and phosphorus levels and decreased serum calcium levels; and in association herewith aberrations in hormonal levels of FGF-23. In turn, the well-known and highly undesirable complications of CKD, i.e. high turnover bone disease and pathological vessel calcification were induced. Furthermore (iron-deficiency) anemia developed quickly. CONCLUSION: The animal model described in this article in many aspects mimics the human situation of the CRS type 4 and will be useful to concomitantly evaluate the effects of new treatment strategies on the various aspects of CRS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170726
[Lr] Last revision date:170726
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1159/000462984

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[PMID]: 28682948
[Au] Autor:Thompson SJ; Riazi S; Kraeva N; Noseworthy MD; Rayner TE; Schneiderman JE; Cifra B; Wells GD
[Ad] Address:From the *Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada; †Malignant Hyperthermia Investigation Unit, Toronto General Hospital, Toronto, Ontario, Canada; ‡Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada; §Department of Electrical and Computer Engineering, School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; ‖Department of Diagnostic Imaging, the Hospital for Sick Children, Toronto, Ontario, Canada; ¶Physiology and Experimental Medicine, the Hospital for Sick Children, Toronto, Ontario, Canada; and #Division of Cardiology, the Labatt Family Heart Centre, the Hospital for Sick Children, Toronto, Ontario, Canada.
[Ti] Title:Skeletal Muscle Metabolic Dysfunction in Patients With Malignant Hyperthermia Susceptibility.
[So] Source:Anesth Analg;125(2):434-441, 2017 Aug.
[Is] ISSN:1526-7598
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Malignant hyperthermia (MH), a pharmacogenetic disorder of skeletal muscle, presents with a potentially lethal hypermetabolic reaction to certain anesthetics. However, some MH-susceptible patients experience muscle weakness, fatigue, and exercise intolerance in the absence of anesthetic triggers. The objective of this exploratory study was to elucidate the pathophysiology of exercise intolerance in patients tested positive for MH with the caffeine-halothane contracture test. To this end, we used phosphorus magnetic resonance spectroscopy, blood oxygen level-dependent functional magnetic resonance imaging (MRI), and traditional exercise testing to compare skeletal muscle metabolism in MH-positive patients and healthy controls. METHODS: Skeletal muscle metabolism was assessed using phosphorus magnetic resonance spectroscopy and blood oxygen level-dependent functional MRI in 29 MH-positive patients and 20 healthy controls. Traditional measures of physical capacity were employed to measure aerobic capacity, anaerobic capacity, and muscle strength. RESULTS: During 30- and 60-second exercise, MH-positive patients had significantly lower ATP production via the oxidative pathway compared to healthy controls. MH-positive patients also had a longer recovery time with blood oxygen level-dependent functional MRI compared to healthy controls. Exercise testing revealed lower aerobic and anaerobic capacity in MH-positive patients compared to healthy controls. CONCLUSIONS: Results of this exploratory study suggest that MH-positive patients have impaired aerobic metabolism compared to healthy individuals. This could explain the exercise intolerance exhibited in MH-susceptible patient population.
[Mh] MeSH terms primary: Halothane/pharmacology
Malignant Hyperthermia/physiopathology
Muscle Contraction/drug effects
Muscle, Skeletal/metabolism
[Mh] MeSH terms secundary: Adult
Anesthetics/pharmacology
Anthropometry
Caffeine/pharmacology
Case-Control Studies
Disease Susceptibility
Exercise Test
Female
Humans
Magnetic Resonance Imaging
Male
Malignant Hyperthermia/complications
Metabolic Diseases/complications
Middle Aged
Muscle, Skeletal/physiopathology
Muscular Diseases/complications
Oxygen/blood
Surveys and Questionnaires
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anesthetics); 3G6A5W338E (Caffeine); S88TT14065 (Oxygen); UQT9G45D1P (Halothane)
[Em] Entry month:1708
[Cu] Class update date: 170814
[Lr] Last revision date:170814
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170707
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002232

  9 / 1491 MEDLINE  
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[PMID]: 28569356
[Au] Autor:Mihmanli M; Isil RG; Isil CT; Omeroglu S; Sayin P; Oba S; Ozturk FY; Altuntas Y
[Ad] Address:General Surgery Clinic, Sisli Hamidiye Etfal Education and Research Hospital, Halaskargazi Cad. Etfal Sok., 34733, Sisli, Istanbul, Turkey.
[Ti] Title:Effects of Laparoscopic Sleeve Gastrectomy on Parathyroid Hormone, Vitamin D, Calcium, Phosphorus, and Albumin Levels.
[So] Source:Obes Surg;, 2017 May 31.
[Is] ISSN:1708-0428
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) reduces obesity-related co-morbidities, such as diabetes, hypertension, and hyperlipidemia. Endocrinological abnormalities may occur as undesired side effects. Most centers routinely prescribe folic acid, cyanocobalamin (vitB12), and protein replacement in the postoperative period, but 25-OH-vitamin-D3 (vitD) and intact parathyroid hormone (iPTH) levels are not routinely followed up. The aim of this study was to identify the effects of LSG on iPTH, vitD, calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), and albumin levels. METHODS: Data of morbidly obese patients who underwent LSG between January and December 2014 were studied in this prospectively designed study. Serum levels of iPTH, vitD, Ca, P, folic acid, vitB12, ALP, and albumin were measured preoperatively and postoperatively at the 3rd, 6th, and 12th months. RESULTS: In total, 119 patients were analyzed. All patients had normal iPTH, vitD, Ca, P, folic acid, vitB12, ALP, and albumin values preoperatively, and 31.6% had received vitD supplementation during their nutritionist observation time before surgery. At the 3rd, 6th, and 12th postoperative months, 21 (17.6%), 17 (17.3%), and 1 (0.8%) patients, respectively, had increased iPTH and ALP and decreased vitD levels. A total of 39 (32.7%) patients needed high-dose vitD treatment during a 1 year follow-up. Approximately 37.5% of the patients who received vitD supplementation preoperatively needed vitD supplementation postoperatively. Hospital records of 101 of 119 patients who underwent LSG could be screened to determine their vitD supplementation requirements previously ordered by their nutritionist for a 1-year period before LSG. Thirty-two (31.6%) of the 101 patients had received vitD supplementation during the 1-year period preoperatively. CONCLUSIONS: Although serum levels of iPTH, vitD, Ca, P, vitB12, ALP, and albumin may be normal preoperatively, severe vitD insufficiency requiring high-dose vitD replacement may develop in morbidly obese patients postoperatively. Instead of iPTH and vitD, which are expensive to measure, ALP serum level, which is correlated with iPTH levels, can be a good indicator to monitor calcium metabolism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170601
[Lr] Last revision date:170601
[St] Status:Publisher
[do] DOI:10.1007/s11695-017-2747-x

  10 / 1491 MEDLINE  
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[PMID]: 28487345
[Au] Autor:Wang M; Obi Y; Streja E; Rhee CM; Lau WL; Chen J; Hao C; Hamano T; Kovesdy CP; Kalantar-Zadeh K
[Ad] Address:Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, California.
[Ti] Title:Association of Parameters of Mineral Bone Disorder with Mortality in Patients on Hemodialysis according to Level of Residual Kidney Function.
[So] Source:Clin J Am Soc Nephrol;12(7):1118-1127, 2017 Jul 07.
[Is] ISSN:1555-905X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND AND OBJECTIVES: The relationship between mineral and bone disorders and survival according to residual kidney function status has not been previously studied in patients on hemodialysis. We hypothesized that residual kidney function, defined by renal urea clearance, modifies the association between mineral and bone disorder parameters and mortality. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The associations of serum phosphorus, albumin-corrected calcium, intact parathyroid hormone, and alkaline phosphatase with all-cause mortality were examined across three strata (<1.5, 1.5 to <3.0, and ≥3.0 ml/min per 1.73 m ) of baseline residual renal urea clearance using Cox models adjusted for clinical characteristics and laboratory measurements in 35,114 incident hemodialysis patients from a large United States dialysis organization over the period of 2007-2011. RESULTS: A total of 8102 (23%) patients died during the median follow-up of 1.3 years (interquartile range, 0.6-2.3 years). There was an incremental mortality risk across higher serum phosphorus concentrations, which was pronounced among patients with higher residual renal urea clearance ( =0.001). Lower concentrations of serum intact parathyroid hormone were associated with higher mortality among patients with low residual renal urea clearance ( , <1.5 ml/min per 1.73 m ), whereas higher concentrations showed a higher mortality risk among patients with greater residual renal urea clearance ( , ≥1.5 ml/min per 1.73 m ; <0.001). Higher serum corrected total calcium and higher alkaline phosphatase concentrations consistently showed higher mortality risk ( <0.001 for both) irrespective of residual renal urea clearance strata ( =0.34 and =0.53, respectively). CONCLUSIONS: Residual kidney function modified the mortality risk associated with serum phosphorus and intact parathyroid hormone among incident hemodialysis patients. Future studies are needed to examine whether taking account for residual kidney function into the assessment of mortality risk associated with serum phosphorus and intact parathyroid hormone improves patient management and clinical outcomes in the hemodialysis population.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170804
[Lr] Last revision date:170804
[St] Status:In-Process
[do] DOI:10.2215/CJN.11931116


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