Database : MEDLINE
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[PMID]: 29462698
[Au] Autor:Yeo ETY; Wong KWL; See ML; Wong KY; Gan SY; Chan EWL
[Ad] Address:School of Pharmacy, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia. Electronic address: Emilia.YeoTzeYing@student.imu.edu.my.
[Ti] Title:Piper sarmentosum Roxb. confers neuroprotection on beta-amyloid (Aß)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation in SH-SY5Y cells.
[So] Source:J Ethnopharmacol;217:187-194, 2018 Feb 17.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Piper sarmentosum Roxb. (PS), belonging to Piperaceae family, is an edible plant with medicinal properties. It is traditionally used by the Malays to treat headache and boost memory. Pharmacological studies revealed that PS exhibits anti-inflammatory, anti-oxidant, anti-acetylcholinesterase, and anti-depressant-like effects. In view of this, the present study aimed to investigate the anti-inflammatory actions of PS and its potential neuroprotective effects against beta-amyloid (Aß)-induced microglia-mediated neurotoxicity. MATERIALS AND METHODS: The inhibitory effects of hexane (L ), dichloromethane (L ), ethyl acetate (L ) and methanol (L ) extracts from leaves of PS on Aß-induced production and mRNA expression of pro-inflammatory mediators in BV-2 microglial cells were assessed using colorimetric assay with Griess reagent, ELISA kit and real-time RT-PCR respectively. Subsequently, MTT reduction assay was used to evaluate the neuroprotective effects of PS leaf extracts against Aß-induced microglia-mediated neurotoxicity in SH-SY5Y neuroblastoma cells. The levels of tau proteins phosphorylated at threonine 231 (pT231) and total tau proteins (T-tau) were determined using ELISA kits. RESULTS: Polar extracts of PS leaves (L and L ) reduced the Aß-induced secretion of pro-inflammatory cytokines (IL-1ß and TNF-α) in BV-2 cells by downregulating the mRNA expressions of pro-inflammatory cytokines. The inhibition of nitric oxide (NO) production could be due to the free radical scavenging activity of the extracts. In addition, conditioned media from Aß-induced BV-2 cells pre-treated with L and L protected SH-SY5Y cells against microglia-mediated neurotoxicity. Further mechanistic study suggested that the neuroprotective effects were associated with the downregulation of phosphorylated tau proteins. CONCLUSIONS: The present study suggests that polar extracts of PS leaves confer neuroprotection against Aß-induced microglia-mediated neurotoxicity in SH-SY5Y cells by attenuating tau hyperphosphorylation through their anti-inflammatory actions and could be a potential therapeutic agent for Alzheimer's disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher

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[PMID]: 29428241
[Au] Autor:Durant-Archibold AA; Santana AI; Gupta MP
[Ad] Address:Biochemistry and Molecular Medicine Research Unit, Center for Drug Discovery and Biodiversity Institute of Scientific Research and High Technology Services (INDICASAT, AIP), Panama City, Panama; College of Natural, Exact Sciences and Technology, University of Panama, Panama City, Panama. Electronic address: adurant@indicasat.org.pa.
[Ti] Title:Ethnomedical uses and pharmacological activities of most prevalent species of genus Piper in Panama: A review.
[So] Source:J Ethnopharmacol;217:63-82, 2018 Feb 09.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Piperaceae is the fifth largest family of plants in Panama. This review focuses on the ethnomedical uses of the most prevalent Panamanian species and biological activities of their extracts and/or constituents both in Panama and worldwide. Many species have a plethora of ethnomedical uses such as antibacterial, antifungal, anti-inflammatory, anticancer, antidiabetic, anti-Helicobacter pylori, antiulcer, antiprotozoal, estrogenic, insecticidal, local anesthetic, diuretic, and for women's health conditions. AIM OF THE REVIEW: The aim of this review is to compile all ethnomedical uses of most prevalent species of Piper in Panama, and their extracts or phytoconstituents worldwide, through a complete literature search, so that it may allow selection of potential unexplored Piper species for future research and development of phytotherapeuticals for important ailments. METHODOLOGY: This review conducted a thorough search in books and databases such as Google Scholar, PubMed, Sci-Finder, Scopus, ACS publications, Science Direct, and Reaxys (Elsevier), until October of 2017. The information provided in this review is based on peer-reviewed papers only in English. The key words used to search were: "Piper", "Piperaceae", "Panama", "Pharmacological activity", "Chemistry," "Toxicity," and "Clinical studies". Scientific names of the plants were validated through www.tropicos.org. Potential full-texts of eligible papers, irrespective of database, were identified. Study selection and data extraction were conducted by one author (AIS) and confirmed by others (MPG, ADA). The extracted data were summarized in tabular form and a narrative description was used to provide a summary of updated information. RESULTS: The ethnomedical uses of most prevalent 23 Panamanian species of Piper both in Panama as well in the world are provided. Of these species only Piper arboreum, Piper auritum, Piper cordulatum, Piper hispidum, Piper dariense, Piper multiplinervium and Piper umbellatum have ethnomedical uses in Panama. Some of the uses are by native Amerindians of Panama. These include ailments such as liver pains, common colds, skin infections, insecticidal, as a bath to alleviate colds, snakebites, different types of pains, skin ailments, wound healing, rheumatism, women's health, antipyretic, and anti-inflammatory. Other Panamanian species are widely used in many countries of the world. Of all the Piper species, P. aduncum has the most ethnomedical uses. Panamanian uses are different from the ones in other countries. A total of 61 compounds present in Piper species reported in this review have shown a variety of biological activities in vitro. These compounds belong to different chemical types, such as chromenes, amides, alkaloids, benzopyrans, benzoates, essential oils, pyrrolidines, flavokaines, chalcones, methylenedioxy propiophenones, cinnamates, monoterpenes, sesquiterpenes, phenols, among others. From this review it is evident that extracts and pure compounds isolated from Piper species have shown a wide array of mainly in vitro activity and some ethnomedical uses may be correlated with their activities reported. CONCLUSIONS: Plants of this genus have provided bioactive species, both from crude extracts and pure compounds thus substantiating their efficacy in traditional medicine. In vivo and toxicological studies are still limited, but the results of different activities of Piper reported point out the great potential of these species for obtaining bioactive principles that may be useful in treating diseases. However, a thorough investigation of Piper species relating to chemistry, in vivo pharmacological activities, with emphasis on their mechanism of action, safety and efficacy and toxicity is warranted.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher

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[PMID]: 29479742
[Au] Autor:Dos Santos AL; Novaes ADS; Polidoro ADS; de Barros ME; Mota JS; Lima DBM; Krause LC; Cardoso CAL; Jacques RA; Caramão EB
[Ad] Address:Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
[Ti] Title:Chemical characterisation of Piper amalago (Piperaceae) essential oil by comprehensive two-dimensional gas chromatography coupled with rapid-scanning quadrupole mass spectrometry (GC×GC/qMS) and their antilithiasic activity and acute toxicity.
[So] Source:Phytochem Anal;, 2018 Feb 26.
[Is] ISSN:1099-1565
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Piper amalago has a distribution from Mexico to Brazil; their aerial parts have been used in folk medicine to treat diuretic and kidney diseases. OBJECTIVE: The purpose of this study was to obtain a deeper understanding of the chemical composition of essential oils (EOs) extracted from both the leaves and stems of P. amalago, compare them, and evaluate their antilithiasic activity and acute toxicity. METHODOLOGY: Extraction was performed by hydrodistillation, whereas chemical characterisation by two-dimensional gas chromatography coupled with rapid-scanning quadrupole mass spectrometry (GC×GC/qMS). The antilithiasic activity was evaluated by the effect of the EOs on calcium oxalate crystallisation in vitro. The turbidity index and the number of crystals formed were determined and used as an estimative of the activity. In the acute toxicity assay, the effects of a single oral dose of the EOs in Wistar rats were determined. General behaviour, adverse effects, and mortality were determined. RESULTS: A total of 322 compounds were identified in the EOs. The sesquiterpenes displayed the highest contribution in leaves EOs among which included bicyclogermacrene and δ-cadinene. Sesquiterpenes and oxygenated sesquiterpenes displayed the highest contribution in EOs from stems, among which included bicyclogermacrene and α-cadinol. The EOs demonstrated an excellent action on the crystals growth inhibition, and the oral dose tested did not induce significant changes in the parameters for acute toxicity. CONCLUSION: The oils have a high chemical complexity, and there are differences between their compositions, which could explain the observed differences in antilithiasic activity. The findings support the use of this plant in folk medicine to treat kidney diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher
[do] DOI:10.1002/pca.2747

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[PMID]: 29461056
[Au] Autor:Dethe DH; Dherange BD
[Ad] Address:Department of Chemistry, Indian Institute of Technology Kanpur , Kanpur-208016, India.
[Ti] Title:Total Synthesis of Adunctin B.
[So] Source:J Org Chem;, 2018 Feb 23.
[Is] ISSN:1520-6904
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Total synthesis of (±)-adunctin B, a natural product isolated from Piper aduncum (Piperaceae), has been achieved using two different strategies, in seven and three steps. The efficient approach features highly atom economical and diastereoselective Friedel-Crafts acylation, alkylation reaction and palladium catalyzed Wacker type oxidative cyclization.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:Publisher
[do] DOI:10.1021/acs.joc.8b00015

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[PMID]: 29451764
[Au] Autor:Montoya-Bustamante S; Rojas-Díaz V; Torres-González AM
[Ti] Title:Interactions between frugivorous bats (Chiroptera: Phyllostomidae) and Piper tuberculatum (Piperaceae) in a tropical dry forest in Valle del Cauca, Colombia.
[So] Source:Rev Biol Trop;64(2):701-13, 2016 Jun.
[Is] ISSN:0034-7744
[Cp] Country of publication:Costa Rica
[La] Language:eng
[Ab] Abstract:In any ecosystem, fruits are resources that vary in time and space as well as in nutritional content. Coexistence of species from a trophic guild depends on the division and use of resources. Therefore, the organisms that depend on them as a food source, tend to show a certain degree of specialization. This way, understanding the factors that influence the dynamics of seed dispersal is important for the regeneration and conservation of tropical ecosystems. Our aim was to determine variation in consumption of Piper tuberculatum by fruit bat assemblages in the village of Robles (Jamundí, Valle del Cauca, Colombia). P. tuberculatum is a resource used not only by wildlife but also by people in the village of Robles. Bats were captured in mist nets between June and November 2014, their feces were collected, and the length of the forearm, wing area, leg length and mass were recorded. At the Universidad del Valle seed laboratory, fecal samples were washed, and their content determined. Of the 14 species captured, Sturnira lilium, Carollia brevicauda, Carollia perspicillata and Artibeus lituratus showed signs of having consumed P. tuberculatum. Sturnira lilium was the main consumer of P. tuberculatum fruits, with the greatest number of consumption events of fruit from this plant species, whereas the other bats showed more diversified consumption events. The greatest niche overlap was recorded between C. brevicauda and C. perspicillata, species that showed similar sizes (i.e., wing area and forearm length) followed by S. lilium and C. perspicillata. In contrast, A. lituratus showed the least niche overlap with the other three fruit bats captured. In conclusion, Sturnira lilium showed an interaction Sturnira-Piper, which is the result of low Solanum availability, and this bat species was the largest consumer of P. tuberculatum in the region.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:In-Process

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[PMID]: 29229570
[Au] Autor:Neamsuvan O; Komonhiran P; Boonming K
[Ad] Address:Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand. Electronic address: oratai.n@psu.ac.th.
[Ti] Title:Medicinal plants used for hypertension treatment by folk healers in Songkhla province, Thailand.
[So] Source:J Ethnopharmacol;214:58-70, 2018 Mar 25.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Hypertension is the most dominant risk factor for the development of cardiovascular, kidney, and eye diseases. In Thailand, illness and hospitalisation in the modern public health system due to high blood pressure is increasing. However, some Thai people have turned their attention to the use of herbal medicines for healthcare. Therefore, this study aimed (1) to study the folk knowledge of hypertension treatment and (2) to study plant utilisation in the treatment of high blood pressure by Songkhla folk healers. MATERIALS AND METHODS: Field surveys and semi-structured interviews about theories of disease, principles of healing, and herbal usage (plant species, parts used, preparation, and application methods) were gathered. The data were analysed by descriptive statistics. The literatures regarding medicinal plants used in any traditional medicine, antihypertension activity, and toxicity was reviewed. RESULTS: Most healers believed that hypertension was caused by the disorder of fire and wind elements in the body. The medicinal plants containing hot and mild tastes, which had the potential for treating problems in the wind element, were applied. A total of 62 species were used for hypertension treatment. Most plants were in the Asteraceae, Piperaceae, Rutaceae, or Zingiberaceae family (4 species each). Herbal medicines were preferred to be prepared by boiling (78%) and consumed by drinking 1 teacup before 3 meals each day (26%). Piper retrofractum and Cleome viscosa had the greatest Frequency of Citation (FC = 6, n = 14). Thirty-seven species have been reported for use in traditional medicine. Twenty-four and 46 species have already been investigated for antihypertension activity and toxicity, respectively. CONCLUSION: Identifying medicinal plants that have been tested by experienced folk doctors would provide an opportunity for people to choose and consume local herbs that are easy to access in their local area. However, the remaining plants that have not been studied for antihypertension activity and toxicity should be further analysed to confirm their efficacy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180115
[Lr] Last revision date:180115
[St] Status:In-Process

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[PMID]: 29240662
[Au] Autor:da Silva JK; da Trindade R; Alves NS; Figueiredo PL; Maia JGS; Setzer WN
[Ad] Address:Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Pará, Belém 66075-900, Brazil. joycekellys@ufpa.br.
[Ti] Title:Essential Oils from Neotropical Piper Species and Their Biological Activities.
[So] Source:Int J Mol Sci;18(12), 2017 Dec 14.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The genus is the most representative of the Piperaceae reaching around 2000 species distributed in the pantropical region. In the Neotropics, its species are represented by herbs, shrubs, and lianas, which are used in traditional medicine to prepare teas and infusions. Its essential oils (EOs) present high yield and are chemically constituted by complex mixtures or the predominance of main volatile constituents. The chemical composition of EOs displays interspecific or intraspecific variations, according to the site of collection or seasonality. The main volatile compounds identified in EOs are monoterpenes hydrocarbons, oxygenated monoterpenoids, sesquiterpene hydrocarbons, oxygenated sesquiterpenoids and large amounts of phenylpropanoids. In this review, we are reporting the biological potential of EOs from the Neotropical region. There are many reports of EOs as antimicrobial agents (fungi and bacteria), antiprotozoal ( spp., spp., and spp.), acetylcholinesterase inhibitor, antinociceptive, anti-inflammatory and cytotoxic activity against different tumor cells lines (breast, leukemia, melanoma, gastric, among others). These studies can contribute to the rational and economic exploration of species, once they have been identified as potent natural and alternative sources to treat human diseases.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180109
[Lr] Last revision date:180109
[St] Status:In-Process

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[PMID]: 29200848
[Au] Autor:Mendes AN; Filgueiras LA; Siqueira MRP; Barbosa GM; Holandino C; de Lima Moreira D; Pinto JC; Nele M
[Ad] Address:Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Piauí.
[Ti] Title:Encapsulation of (Piperaceae) nonpolar extract in poly(methyl methacrylate) by miniemulsion and evaluation of increase in the effectiveness of antileukemic activity in K562 cells.
[So] Source:Int J Nanomedicine;12:8363-8373, 2017.
[Is] ISSN:1178-2013
[Cp] Country of publication:New Zealand
[La] Language:eng
[Ab] Abstract:This study aimed to synthesize and characterize nanoparticles (NPs) of poly(methyl methacrylate) (PMMA) and evaluate their ability to incorporate plant extracts with antitumor activity and low dissolution in aqueous media. The extract used was -hexane partition of the methanol extract of (PCA-HEX). PMMA NPs were obtained using the mini-emulsion method, which was able to encapsulate almost 100% of PCA-HEX. The synthesized polymeric particles presented with a size of 200 nm and a negative charge. Cytotoxicity tests by MTT and trypan blue assays showed that NPs without PCA-HEX did not kill leukemic cells (K562 cells). NPs containing PCA-HEX were able to enhance cell death when compared to pure extract. The results showed that PMMA NPs could be useful as a drug delivery system as they can enhance the antitumor activity of the PCA-HEX extract by more than 20-fold. PMMA NPs containing plant extracts with antitumor activities may be an alternative to control the evolution of diseases such as leukemia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171220
[Lr] Last revision date:171220
[St] Status:In-Process
[do] DOI:10.2147/IJN.S134756

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[PMID]: 29131478
[Au] Autor:Yeo BPH; Foong LC; Tam SM; Lee V; Hwang SS
[Ad] Address:Faculty of Engineering Computing and Science, Swinburne University of Technology Sarawak Campus, Jalan Simpang Tiga, Kuching 93330, Malaysia.
[Ti] Title:Gene isolation using degenerate primers targeting protein motif: A laboratory exercise.
[So] Source:Biochem Mol Biol Educ;, 2017 Nov 13.
[Is] ISSN:1539-3429
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Structures and functions of protein motifs are widely included in many biology-based course syllabi. However, little emphasis is placed to link this knowledge to applications in biotechnology to enhance the learning experience. Here, the conserved motifs of nucleotide binding site-leucine rich repeats (NBS-LRR) proteins, successfully used for the isolation and characterization of many plant resistance gene analogues (RGAs), is featured in the development of a series of laboratory experiments using important molecular biology techniques. A set of previously isolated RGA sequences is used as the model for performing sequence alignment and visualising 3D protein structure using current bioinformatics programs (Clustal Omega and Argusdock software). A pair of established degenerate primer sequences is provided for the prediction of targeted amino acids sequences in the RGAs. Reverse transcription-polymerase chain reaction (RT-PCR) is used to amplify RGAs from total RNA samples extracted from the tropical wild relative of black pepper, Piper colubrinum (Piperaceae). This laboratory exercise enables students to correlate specific DNA sequences with respective amino acid codes and the interaction between conserved motifs of resistance genes with putatively targeted proteins. © 2017 by The International Union of Biochemistry and Molecular Biology, 2017.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171113
[Lr] Last revision date:171113
[St] Status:Publisher
[do] DOI:10.1002/bmb.21089

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[PMID]: 29123924
[Au] Autor:Vinturelle R; Mattos C; Meloni J; Nogueira J; Nunes MJ; Vaz IS; Rocha L; Lione V; Castro HC; Chagas EFD
[Ad] Address:Laboratório de Estudos em Pragas e Parasitos, Universidade Federal Fluminense, IB, Departamento de Biologia Celular e Molecular-GCM, Niterói, RJ, Brazil.
[Ti] Title: Evaluation of Essential Oils Derived from (Piperaceae) and (Rutaceae) against the Tick (Acari: Ixodidae).
[So] Source:Biochem Res Int;2017:5342947, 2017.
[Is] ISSN:2090-2247
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The present research aimed to study the chemical composition and acaricidal activity of and essential oils against the cattle tick . GC-MS analysis of essential oil showed limonene (50.3%), -pinene (14.4%), and -terpinene (11.7%) as the major components; oil was mainly composed of -caryophyllene (26.2%), -ocymene (5.8%), and -pinene (5.5%). Acaricide activity was evaluated at concentrations of 2.5, 5.0, and 10.0% (v/v) of each plant oil, as well as 1 : 1 combination of both oils (5% : 5%, 2.5% : 2.5%, and 1.25% : 1.25% each), by immersing engorged females for one minute. The LC90 of oils from and the combination were 4.9%, 14.8%, and 5.1%, respectively. essential oil caused 100% mortality of engorged females at the highest concentration (10%). essential oil inhibited egg-laying by up to 96% in a concentration-dependent manner, suggesting it reduces tick fecundity. When combined, the oils presented toxicity as to oil alone, but with stronger inhibition of oviposition (5% : 5%), indicating a possible additive effect against . The present data provide support for further investigation of novel natural products to control bovine tick infestations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171112
[Lr] Last revision date:171112
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2017/5342947


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