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[PMID]: 28371557
[Au] Autor:Varela MT; Lima ML; Galuppo MK; Tempone AG; de Oliveira A; Lago JHG; Fernandes JPS
[Ad] Address:Departamento de Ciências Farmacêuticas, Universidade Federal de São Paulo, Diadema, SP, Brazil.
[Ti] Title:New alkenyl derivative from Piper malacophyllum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum.
[So] Source:Chem Biol Drug Des;90(5):1007-1011, 2017 Nov.
[Is] ISSN:1747-0285
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Alkylphenols isolated from Piper malacophyllum (Piperaceae), gibbilimbols A and B, showed interesting activity against the parasites Trypanosoma cruzi and Leishmania infantum. In continuation to our previous work, a new natural product from the essential oil of the leaves of P. malacophyllum was isolated, the 5-[(3E)-oct-3-en-1-il]-1,3-benzodioxole, and also a new set of five compounds was prepared. The antiparasitic activity of the natural product was evaluated in vitro against these parasites, indicating potential against the promastigote/trypomastigote/amastigote forms (IC 32-83 µm) of the parasites and low toxicity (CC  > 200 µm) to mammalian cells. The results obtained to the synthetic compounds indicated that the new derivatives maintained the promising antiparasitic activity, but the cytotoxicity was considerably lowered. The amine derivative LINS03011 displayed the most potent IC values (13.3 and 16.7 µm) against amastigotes of T. cruzi and L. infantum, respectively, indicating comparable activity to the phenolic prototype LINS03003, with threefold decreased (CC 73.5 µm) cytotoxicity, leading the selectivity index (SI) towards the parasites up to 24.5. In counterpart, LINS03011 has not shown membrane disruptor activity in SYTOX Green model. In summary, this new set showed the hydroxyl is not essential for the antiparasitic activity, and its substitution could decrease the toxicity to mammalian cells.
[Pt] Publication type:LETTER
[Em] Entry month:1704
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[St] Status:In-Process
[do] DOI:10.1111/cbdd.12986

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[PMID]: 28385541
[Au] Autor:Rosado-Aguilar JA; Arjona-Cambranes K; Torres-Acosta JFJ; Rodríguez-Vivas RI; Bolio-González ME; Ortega-Pacheco A; Alzina-López A; Gutiérrez-Ruiz EJ; Gutiérrez-Blanco E; Aguilar-Caballero AJ
[Ad] Address:Departamento de Salud Animal y Medicina Preventiva, Facultad de Medicina Veterinaria y Zootecnia. Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Carretera Mérida-Xmatkuil Km. 15.5 Apdo, Post: 4-116 Itzimná, C.P. 97100, Mérida, Yucatán, Mexico. Electronic address: alb
[Ti] Title:Plant products and secondary metabolites with acaricide activity against ticks.
[So] Source:Vet Parasitol;238:66-76, 2017 Apr 30.
[Is] ISSN:1873-2550
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The present review documents the results of studies evaluating the acaricidal activity of different plant products and secondary metabolites against ticks that are resistant and susceptible to conventional acaricides. Studies published from 1998 to 2016 were included. The acaricidal activity of plant extracts, essential oils and secondary compounds from plants have been evaluated using bioassays with ticks in the larval and adult stages. There is variable effectiveness according to the species of plant and the concentrations used, with observed mortalities ranging from 5 to 100% against the Rhipicephalus (Boophilus), Amblyomma, Dermacentor, Hyalomma, and Argas genera. A number of plants have been reported to cause high mortalities and/or affect the reproductive capacity of ticks in the adult phase. In the majority of these trials, the main species of plants evaluated correspond to the families Lamiaceae, Fabaceae, Asteraceae, Piperaceae, Verbenaceae, and Poaceae. Different secondary metabolites such as thymol, carvacrol, 1,8-cineol and n-hexanal, have been found to be primarily responsible for the acaricidal activity of different essential oils against different species of ticks, while nicotine, dibenzyldisulfide and dibenzyltrisulfide have been evaluated for plant extracts. Only thymol, carvacrol and 1,8-cineol have been evaluated for acaricidal activity under in vivo conditions. The information in the present review allows the conclusion that the secondary metabolites contained in plant products could be used as an alternative for the control of ticks that are susceptible or resistant to commercial acaricides.
[Mh] MeSH terms primary: Acaricides/pharmacology
Plant Extracts/pharmacology
Ticks/drug effects
[Mh] MeSH terms secundary: Animals
Plant Extracts/chemistry
Plants, Medicinal/chemistry
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Acaricides); 0 (Plant Extracts)
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[Js] Journal subset:IM
[Da] Date of entry for processing:170407
[St] Status:MEDLINE

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[PMID]: 29066080
[Au] Autor:Bui TT; Piao CH; Song CH; Shin HS; Shon DH; Chai OH
[Ad] Address:Department of Anatomy, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea.
[Ti] Title:Piper nigrum extract ameliorated allergic inflammation through inhibiting Th2/Th17 responses and mast cells activation.
[So] Source:Cell Immunol;, 2017 Oct 16.
[Is] ISSN:1090-2163
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Piper nigrum (Piperaceae) is commonly used as a spice and traditional medicine in many countries. P. nigrum has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the effect of P. nigrum on allergic asthma has not been known. This study investigated the effect of P. nigrum ethanol extracts (PNE) on airway inflammation in asthmatic mice model. In the ovalbumin (OVA)-induced allergic asthma model, we analysed the number of inflammatory cells and cytokines production in bronchoalveolar lavage fluid (BALF) and lung tissue; histological structure; as well as the total immunoglobulin (Ig)E, anti-OVA IgE, anti-OVA IgG and histamine levels in serum. The oral administration (200 mg/kg) of PNE reduced the accumulation of inflammatory cells (eosinophils, neutrophils in BALF and mast cells in lung tissue); regulated the balance of the cytokines production of Th1, Th2, Th17 and Treg cells, specifically, inhibited the expressions of GATA3, IL-4, IL-6, IL-1ß, RORγt, IL-17A, TNF-α and increased the secretions of IL-10, INF-γ in BALF and lung homogenate. Moreover, PNE suppressed the levels of total IgE, anti-OVA IgE, anti-OVA IgG and histamine release in serum. The histological analysis showed that the fibrosis and infiltration of inflammatory cells were also ameliorated in PNE treated mice. On the other hand, PNE inhibited the allergic responses via inactivation of rat peritoneal mast cells degranulation. These results suggest that PNE has therapeutic potential for treating allergic asthma through inhibiting Th2/Th17 responses and mast cells activation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171025
[Lr] Last revision date:171025
[St] Status:Publisher

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[PMID]: 28442412
[Au] Autor:Marques AM; Fingolo CE; Kaplan MAC
[Ad] Address:Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Pesquisas de Produtos Naturais (IPPN) Brasil, CEP: 21941-590, Rio de Janeiro, RJ, Brazil. Electronic address: andrefarmaciarj@yahoo.com.br.
[Ti] Title:HSCCC separation and enantiomeric distribution of key volatile constituents of Piper claussenianum (Miq.) C. DC. (Piperaceae).
[So] Source:Food Chem Toxicol;109(Pt 2):1111-1117, 2017 Nov.
[Is] ISSN:1873-6351
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:High Speed Countercurrent Chromatography (HSCCC) technique was used for the preparative isolation of the major leishmanicidal compounds from the essential oils of Piper claussenianum species in Brazil. The essential oils from inflorescences of P. claussenianum were analyzed by GC-FID and GC-MS. The enantiomeric ratio of the major constituents of the P. claussenianum essential oils were determined using a Rt-DEXsm chiral capillary column by GC-FID analysis. It was found an enantiomeric excess of (+)-(E)-nerolidol in the leaves, and (+)-linalool and (+)-(E)-nerolidol in the inflorescences essential oil. The major volatile terpenes alcohols were isolated in preparative scale from inflorescences: linalool (320.0 mg) and nerolidol (95.0 mg) in high purity level. The HSCCC, a support-free liquid-liquid partition chromatographic technique, proved to be an effective and useful method for fast isolation and purification of hydrophobic and similarly structured bioactive components from essential oils of Piper species.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 171025
[Lr] Last revision date:171025
[St] Status:In-Process

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[PMID]: 28416272
[Au] Autor:Andrés MF; Rossa GE; Cassel E; Vargas RMF; Santana O; Díaz CE; González-Coloma A
[Ad] Address:Instituto de Ciencias Agrarias, CSIC, Serrano 115-bis, 28006 Madrid, Spain.
[Ti] Title:Biocidal effects of Piper hispidinervum (Piperaceae) essential oil and synergism among its main components.
[So] Source:Food Chem Toxicol;109(Pt 2):1086-1092, 2017 Nov.
[Is] ISSN:1873-6351
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In this study we evaluated the effect of a pressure gradient (1-2 atm) in the extraction and composition of the essential oil (EO) of Piper hispidinervum by steam distillation. We also evaluated the insect antifeedant effects (Spodoptera littoralis, Leptinotarsa decemlineata, Myzus persicae and Rhopalosiphum padi) and nematicidal activity (Meloidogyne javanica) of the oils, their major components and their synergistic interactions. Safrole was the major component (78-81%) followed by terpinolene (5-9%). The EOs tested were effective insect antifeedants. Safrole, explained most of the insect antifeedant action of P. hispidinervum EOs. When safrole and terpinolene were tested in binary combinations, low ratios of safrole improved the antifeedant effects of terpinolene. P. hispidinervum EOs caused higher mortality of M. javanica juveniles than their major components. In binary combinations, low ratios of terpinolene increased the nematicidal effects of safrole. The EO treatment strongly suppressed nematode egg hatching and juvenile infectivity. P. hispidinervum EOs affected the germination of S. lycopersicum and L. sativa mostly at 24 h of treatment, being L. sativa the most sensitive. Safrole moderately affected germination and root growth of L. sativa, S. lycopersicum and L. perenne. Terpinolene only affected S. lycopersicum root growth.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 171025
[Lr] Last revision date:171025
[St] Status:In-Process

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[PMID]: 28978254
[Au] Autor:Atiya A; Sinha BN; Ranjan Lal U
[Ad] Address:a Division of Pharmacognosy and Phytochemistry, Department of Pharmaceutical Sciences and Technology , Birla Institute of Technology , Mesra , India.
[Ti] Title:New chemical constituents from the Piper betle Linn. (Piperaceae).
[So] Source:Nat Prod Res;:1-8, 2017 Oct 05.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The phytochemical investigation of chloroform extract from Piper betle var. haldia, Piperaceae, leaves has resulted in the isolation of two new chemical constituents which were identified as 1-n-dodecanyloxy resorcinol (H1) and desmethylenesqualenyl deoxy-cepharadione-A (H4), on the basis of spectroscopic data 1D NMR ( H and C) and 2D NMR ( H- H COSY and HMBC) as well as ESI-MS, FT-IR and HR-ESI-MS analyses. Compounds H1 and H4 showed excellent antioxidant DPPH free radical scavenging activity with IC values of 7.14 µg/mL and 8.08 µg/mL compared to ascorbic acid as a standard antioxidant drug with IC value of 2.52 µg/mL, respectively. Evaluation of cytotoxic activity against human hepatoma cell line (PLC-PRF-5) showed moderate effect with the GI values of 35.12 µg/mL for H1, 31.01 µg/mL for H4, compared to Doxorubicin as a standard cytotoxic drug with GI value of 18.80 µg/mL.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171005
[Lr] Last revision date:171005
[St] Status:Publisher
[do] DOI:10.1080/14786419.2017.1380018

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[PMID]: 28278665
[Au] Autor:Atiya A; Sinha BN; Lal UR
[Ad] Address:a Division of Pharmacognosy and Phytochemistry, Department of Pharmaceutical Sciences and Technology , Birla Institute of Technology , Mesra, Ranchi , India.
[Ti] Title:Bioactive phenylpropanoid analogues from Piper betle L. var. birkoli leaves.
[So] Source:Nat Prod Res;31(22):2604-2611, 2017 Nov.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Phytochemical analyses of the chloroform extract of Piper betle L. var. birkoli, Piperaceae, leaves led to the isolation of two new phenylpropanoid analogues: bis-chavicol dodecanoyl ester (2) and bis-hydroxychavicol dodecanoyl ester (3), along with one known compound: allyl-3-methoxy-4-hydroxybenzene (1) on the basis of spectroscopic data 1D ( H and C) and 2D ( H- H COSY and HMBC) NMR, as well as ESI-MS, FT-IR, HR-ESI-MS and LC-ESI-MS. Compound 2 and 3 exhibited excellent antioxidant DPPH radical scavenging activity with IC values of 12.67 µg/mL and 1.08 µg/mL compared to ascorbic acid as a standard antioxidant drug with IC value of 6.60 µg/mL. Evaluation of cytotoxic activity against two human oral cancer cell lines (AW13516 and AW8507) showed significant effect with GI values of 19.61 and 23.01 µg/mL for compound 2 and 10.25 and 13.12 µg/mL for compound 3, compared to Doxorubicin as a standard cytotoxic drug with GI value of < 10 µg/mL.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 171006
[Lr] Last revision date:171006
[St] Status:In-Process
[do] DOI:10.1080/14786419.2017.1285297

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Romero, Gustavo Adolfo Sierra
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[PMID]: 28415906
[Au] Autor:Araújo-Vilges KM; Oliveira SV; Couto SCP; Fokoue HH; Romero GAS; Kato MJ; Romeiro LAS; Leite JRSA; Kuckelhaus SAS
[Ad] Address:a Laboratory of Cell Immunology, Faculty of Medicine , University of Brasilia Campus Darcy Ribeiro , Brasilia - DF , Brazil.
[Ti] Title:Effect of piplartine and cinnamides on Leishmania amazonensis, Plasmodium falciparum and on peritoneal cells of Swiss mice.
[So] Source:Pharm Biol;55(1):1601-1607, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: Plants of the Piperaceae family produce piplartine that was used to synthesize the cinnamides. OBJECTIVE: To assess the effects of piplartine (1) and cinnamides (2-5) against the protozoa responsible for malaria and leishmaniasis, and peritoneal cells of Swiss mice. MATERIALS AND METHODS: Cultures of Leishmania amazonensis, Plasmodium falciparum-infected erythrocytes, and peritoneal cells were incubated, in triplicate, with different concentrations of the compounds (0 to 256 µg/mL). The inhibitory concentration (IC ) in L. amazonensis and cytotoxic concentration (CC ) in peritoneal cell were assessed by the MTT method after 6 h of incubation, while the IC for P. falciparum-infected erythrocytes was determined by optical microscopy after 48 or 72 h of incubation; the Selectivity Index (SI) was calculated by CC /IC . RESULTS: All compounds inhibited the growth of microorganisms, being more effective against P. falciparum after 72 h of incubation, especially for the compounds 1 (IC = 3.2 µg/mL) and 5 (IC = 6.6 µg/mL), than to L. amazonensis (compound 1 = 179.0 µg/mL; compound 5 = 106.0 µg/mL). Despite all compounds reducing the viability of peritoneal cells, the SI were <10 to L. amazonensis, whereas in the cultures of P. falciparum the SI >10 for the piplartine (>37.4) and cinnamides 4 (>10.7) and 5 (= 38.4). DISCUSSION AND CONCLUSION: The potential of piplartine and cinnamides 4 and 5 in the treatment of malaria suggest further pre-clinical studies to evaluate their effects in murine malaria and to determine their mechanisms in cells of the immune system.
[Mh] MeSH terms primary: Cinnamates/pharmacology
Leishmania/drug effects
Piperidones/pharmacology
Plasmodium falciparum/drug effects
[Mh] MeSH terms secundary: Animals
Cell Survival/drug effects
Cinnamates/administration & dosage
Cinnamates/chemistry
Dose-Response Relationship, Drug
Erythrocytes/parasitology
Female
Humans
Inhibitory Concentration 50
Male
Mice
Peritoneum/cytology
Peritoneum/drug effects
Piperaceae/chemistry
Piperidones/administration & dosage
Piperidones/isolation & purification
Time Factors
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Cinnamates); 0 (Piperidones); 0 (piplartine)
[Em] Entry month:1710
[Cu] Class update date: 171004
[Lr] Last revision date:171004
[Js] Journal subset:IM
[Da] Date of entry for processing:170418
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1313870

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Romoff, Paulete
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[PMID]: 28906474
[Au] Autor:Tamayose CI; Romoff P; Toyama DO; Gaeta HH; Costa CRC; Belchor MN; Ortolan BD; Velozo LSM; Kaplan MAC; Ferreira MJP; Toyama MH
[Ad] Address:Curso de Química, Universidade Presbiteriana Mackenzie, Rua da Consolação, São Paulo 01302-907, Brazil. cinthiatamay@gmail.com.
[Ti] Title:Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema.
[So] Source:Int J Mol Sci;18(9), 2017 Sep 14.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Compound 8- -rhamnosyl apigenin (8CR) induced a moderate reduction in the enzymatic activity of secretory phospholipase A2 (sPLA2) from and cytosolic phospholipase A2 (cPLA2), but the compound also significantly inhibited the enzymatic activity of the enzyme cyclooxygenase. In vitro assays showed that the compound induced a slight change in the secondary structure of sPLA2 from snake venom. In vivo assays were divided into two steps. In the first step, the 8CR compound was administered by intraperitoneal injections 30 min prior to administration of sPLA2. In this condition, 8CR inhibited edema and myonecrosis induced by the sPLA2 activity of in a dose-dependent manner by decreasing interleukin-1ß (IL-1ß), tumor necrosis factor α (TNF-α), prostaglandin E2 (PGE2), and lipid peroxidation. This has been demonstrated by monitoring the levels of malondialdehyde (MDA) in rat paws after the course of edema induced by sPLA2. These results, for the first time, show that sPLA2 of venom induces massive muscle damage, as well as significant edema by mobilization of cyclooxygenase enzymes. Additionally, its pharmacological activity involves increased lipid peroxidation as well as TNF-α and IL-1ß production. Previous administration by the peritoneal route has shown that dose-dependent 8CR significantly decreases the enzymatic activity of cyclooxygenase enzymes. This resulted in a decrease of the amount of bioactive lipids involved in inflammation; it also promoted a significant cellular protection against lipid peroxidation. In vivo experiments performed with 8CR at a concentration adjusted to 200 µg (8 mg/kg) of intraperitoneal injection 15 min after sPLA2 injection significantly reduced sPLA2 edema and the myotoxic effect induced by sPLA2 through the decrease in the enzymatic activity of cPLA2, cyclooxygenase, and a massive reduction of lipid peroxidation. These results clearly show that 8CR is a potent anti-inflammatory that inhibits cyclooxygenase-2 (COX-2), and it may modulate the enzymatic activity of sPLA2 and cPLA2. In addition, it was shown that sPLA2 increases cell oxidative stress during edema and myonecrosis, and the antioxidant properties of the polyphenolic compound may be significant in mitigating the pharmacological effect induced by sPLA2 and other snake venom toxins.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171001
[Lr] Last revision date:171001
[St] Status:In-Process

  10 / 443 MEDLINE  
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[PMID]: 28837061
[Au] Autor:Zhou J; Chen X; Cui Y; Sun W; Li Y; Wang Y; Song J; Yao H
[Ad] Address:Key Lab of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. jgzhou1316@163.com.
[Ti] Title:Molecular Structure and Phylogenetic Analyses of Complete Chloroplast Genomes of Two Aristolochia Medicinal Species.
[So] Source:Int J Mol Sci;18(9), 2017 Aug 24.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The family Aristolochiaceae, comprising about 600 species of eight genera, is a unique plant family containing aristolochic acids (AAs). The complete chloroplast genome sequences of and are reported here. The results show that the complete chloroplast genomes of and comprise circular 159,793 and 160,576 bp-long molecules, respectively and have typical quadripartite structures. The GC contents of both species were 38.3% each. A total of 131 genes were identified in each genome including 85 protein-coding genes, 37 tRNA genes, eight rRNA genes and one pseudogene ( ). The simple-sequence repeat sequences mainly comprise A/T mononucletide repeats. Phylogenetic analyses using maximum parsimony (MP) revealed that and had a close phylogenetic relationship with species of the family Piperaceae, as well as Laurales and Magnoliales. The data obtained in this study will be beneficial for further investigations on and from the aspect of evolution, and chloroplast genetic engineering.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171001
[Lr] Last revision date:171001
[St] Status:In-Process


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