Database : MEDLINE
Search on : placenta and previa [Words]
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[PMID]: 29521289
[Au] Autor:Shi XM; Wang Y; Zhang Y; Wei Y; Chen L; Zhao YY
[Ad] Address:Department of Obstetrics and Gynaecology, Peking University Third Hospital, Beijing 100191, China.
[Ti] Title:Effect of Primary Elective Cesarean Delivery on Placenta Accreta: A Case-Control Study.
[So] Source:Chin Med J (Engl);131(6):672-676, 2018 Mar 20.
[Is] ISSN:0366-6999
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:Background: Cesarean section (CS) is an independent risk factor for placenta accreta. Some researchers think that the timing of primary cesarean delivery is associated with placenta accreta in subsequent pregnancies. The aim of this study was to investigate the risk of placenta accreta following primary CS without labor, also called primary elective CS, in a pregnancy complicated with placenta previa. Methods:: A retrospective, single-center, case-control study was conducted at Peking University Third Hospital. Relevant clinical data of singleton pregnancies between January 2010 and September 2017 were recorded. The case group included women with placenta accreta who had placenta previa and one previous CS. Control group included women with one previous CS that was complicated with placenta previa. Maternal age, body mass index, gestational age, fetal birth weight, gravity, parity, induced abortion, the rate of women received assisted reproductive technology, other uterine surgery, and primary elective CS were analyzed between the two groups. Results:: The rate of primary elective CS (90.1% vs. 69.9%, P < 0.001) was higher, and maternal age was younger (32.7 ± 4.7 years vs. 34.6 ± 4.0 years, P < 0.001) in case group, compared with control group. Case group also had higher gravity and induced abortions compared with the control group (both P < 0.05). Primary CS without labor was associated with significantly increased risk of placenta accreta in a subsequent pregnancy complicated with placenta previa (odds ratio: 3.32; 95% confidential interval: 1.68-6.58). Conclusion:: Women with a primary elective CS without labor have a higher chance of developing an accreta in a subsequent pregnancy that is complicated with placenta previa.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.4103/0366-6999.226902

  2 / 3029 MEDLINE  
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[PMID]: 29297951
[Au] Autor:Ono Y; Murayama Y; Era S; Matsunaga S; Nagai T; Osada H; Takai Y; Baba K; Takeda S; Seki H
[Ad] Address:Center for Maternal Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
[Ti] Title:Study of the utility and problems of common iliac artery balloon occlusion for placenta previa with accreta.
[So] Source:J Obstet Gynaecol Res;44(3):456-462, 2018 Mar.
[Is] ISSN:1447-0756
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:AIMS: We investigated whether common iliac artery balloon occlusion (CIABO) was effective for decreasing blood loss during cesarean hysterectomy (CH) in patients with placenta previa with accreta and was safe for mothers and fetuses. METHODS: Of the 67 patients who underwent CH for placenta previa with accreta at our facility from 1985 to 2014, 57 patients were eligible for the study. The amount of intraoperative bleeding during CH was compared between three groups: surgery without blood flow occlusion (13 patients), internal iliac artery ligation (15 patients) and CIABO (29 patients). Additionally, multivariate analysis was performed to assess risk factors for massive bleeding during CH. RESULTS: The mean blood loss in the CIABO group (2027 ± 1638 mL) was significantly lower than in the other two groups (3787 ± 2936 mL in the no occlusion, 4175 ± 1921 mL in the internal iliac artery ligation group; P < 0.05). Multivariate analysis showed that spontaneous placental detachment during surgery (odds ratio [OR] 49.174, 95% confidence interval [CI] 4.98-1763.67), a history of ≥ 2 cesarean sections (OR 9.226, 95% CI 1.07-231.15) and no use of CIABO (OR 26.403, 95% CI 3.20-645.17) were significantly related to massive bleeding during surgery. There was no case of necrosis resulting from ischemia. The mean radiation dose during balloon placement never exceeded the threshold value for fetal exposure. CONCLUSION: Bleeding during CH for placenta previa with accreta can be decreased by CIABO. This study also confirmed the safety of CIABO in regard to maternal lower limb ischemia and fetal radiation exposure during balloon placement.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1111/jog.13550

  3 / 3029 MEDLINE  
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[PMID]: 29271032
[Au] Autor:Wang Y; Gao Y; Zhao Y; Chong Y; Chen Y
[Ad] Address:Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
[Ti] Title:Ultrasonographic diagnosis of severe placental invasion.
[So] Source:J Obstet Gynaecol Res;44(3):448-455, 2018 Mar.
[Is] ISSN:1447-0756
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:AIM: Placental invasion is a life-threatening obstetric complication. The aim of this study was to identify the optimal ultrasonographic (US) criteria for placenta increta/percreta in order to improve diagnostic accuracy. METHODS: In a retrospective diagnostic study, all 116 patients at Peking University Third Hospital who had been diagnosed with placental invasion from October 2006 to October 2013 were included. Depending on their clinical and/or histopathological diagnosis, the study was divided into two groups: the Placenta Accreta Group (63 cases) and the Placenta Increta/Percreta Group (53 cases). The US images were analyzed for differences between placenta accreta and placenta increta/percreta. RESULTS: The sonographic criteria found to have predictive value for placenta increta/percreta using a regression model were: deficiency of retroplacental sonolucent zone and/or segmental retroplacental myometrial thinning less than 1 mm, multiple vascular lacunae presenting a 'moth hole' appearance, and placenta previa. Using a cut-off point of 0.589, the sensitivity and specificity were 81.1% and 77.8%, respectively. The area under the receiver-operator curve was 0.848 (P < 0.001). CONCLUSION: US diagnosis not only allows the detection of placental invasion, but also facilitates preliminary classification. The three aforementioned criteria facilitate the identification of placenta increta/percreta for precise and comprehensive clinical decision-making.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1111/jog.13531

  4 / 3029 MEDLINE  
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[PMID]: 29409879
[Au] Autor:Yamashita M; Kumasawa K; Nakamura H; Kimura T
[Ad] Address:Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, Osaka, Japan. Electronic address: uri_ton@hotmail.com.
[Ti] Title:Soluble FLT-1 rules placental destiny.
[So] Source:Biochem Biophys Res Commun;496(4):1243-1249, 2018 02 19.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Placenta previa is an abnormality in which the placenta covers the internal uterine os, and it can cause serious morbidity and mortality in both mother and fetus due to catastrophic hemorrhage. Some pregnant women recover from placenta previa due to a phenomenon called "migration." However, the mechanism of "migration" of the placenta has not been elucidated. METHODS: Human placentas were collected from patients with placenta previa and those with no abnormal placentation (control). A microarray analysis was performed to detect the genes up- or down-regulated only in the caudal part in the previa group. Specific mRNA expression was evaluated using real-time quantitative reverse transcription PCR (qRT-PCR). Unilateral uterine artery ablation of 8.5 dpc mice was performed to reproduce the reduction of placental blood supply, and weights of the placentas and fetuses were evaluated in 18.5 dpc. Specific mRNA expression was also evaluated in mice placentas. RESULTS: According to the result of the microarray analysis, we focused on soluble fms-like tyrosine kinase-1 (sFLT-1) and hypoxia-inducible factor-1 (HIF-1) alpha. The sFLT-1 expression level is locally high in the caudal part of the human placenta in patients with placenta previa. In mice experiments, the weights of the placentas and fetuses were significantly smaller in the ablation side than those in the control side, and the sFlt-1 expression level was significantly higher in the ablation side than in the control side. DISCUSSION: Our study suggests that "migration" of the placenta is derived from placental degeneration at the caudal part of the placenta, and sFlt-1 plays a role in this placental degeneration.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  5 / 3029 MEDLINE  
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[PMID]: 29353034
[Au] Autor:Melcer Y; Jauniaux E; Maymon S; Tsviban A; Pekar-Zlotin M; Betser M; Maymon R
[Ad] Address:Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
[Ti] Title:Impact of targeted scanning protocols on perinatal outcomes in pregnancies at risk of placenta accreta spectrum or vasa previa.
[So] Source:Am J Obstet Gynecol;, 2018 Jan 17.
[Is] ISSN:1097-6868
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Placenta accreta spectrum and vasa previa (VP) are congenital disorders of placentation associated with high morbidity and mortality for both mothers and newborns when undiagnosed before delivery. Prenatal diagnosis of these conditions is essential to allow multidisciplinary management and thus improve perinatal outcomes. OBJECTIVE: The objective of the study was to compare perinatal outcome in women with placenta accreta spectrum or vasa previa before and after implementation of targeted scanning protocols. STUDY DESIGN: This retrospective study included 2 nonconcurrent cohorts for each condition before and after implementation of the corresponding protocols (2004-1012 vs 2013-2016 for placenta accreta spectrum and 1988-2007 vs 2008-2016 for vasa previa). Clinical reports of women diagnosed with placenta accreta spectrum and vasa previa during the study periods were reviewed and outcomes were compared. RESULTS: In total, there were 97 cases of placenta accreta spectrum and 51 cases with vasa previa, all confirmed at delivery. In both cohorts, the prenatal detection rate increased after implementation of the scanning protocols (28 of 65 cases [43.1%] vs 31 of 32 cases [96.9%], P < .001, for placenta accreta spectrum and 9 of 18 cases [50%] vs 29 of 33 cases [87.9%], 87.9%, P < .01 for vasa previa). The perinatal outcome improved also significantly in both cohorts after implementation of the protocols. In the placenta accreta spectrum cohort, the estimated blood loss and the postoperative hospitalization stay decreased between periods (1520 ± 845 vs 1168 ± 707 mL, P < .01, and 10.9 ± 14.1 vs 5.7 ± 2.2 days, P < .05, respectively). In the vasa previa cohort, the number of 5 minute Apgar score ≤5 and umbilical cord pH <7 decreased between periods (5 of 18 cases [27.8%] vs 1 of 33 cases [3%]; P < .05, and 4 of 18 cases [22.2%] vs 1 of 33 cases [3%], P < .05, respectively). CONCLUSION: The implementation of standardized prenatal targeted scanning protocols for pregnant women with risk factors for placenta accreta spectrum and vasa previa was associated with improved maternal and neonatal outcomes. The continuous increases in the rates of caesarean deliveries and use of assisted reproductive technology highlights the need to develop training programs and introduce targeted scanning protocols at the national and international levels.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher

  6 / 3029 MEDLINE  
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[PMID]: 29486851
[Au] Autor:Jung EJ; Cho HJ; Byun JM; Jeong DH; Lee KB; Sung MS; Kim KT; Kim YN
[Ad] Address:Department of Obstetrics and Gynecology, Inje University Busan Paik Hospital, Busan, South Korea.
[Ti] Title:Placental pathologic changes and perinatal outcomes in placenta previa.
[So] Source:Placenta;63:15-20, 2018 Mar.
[Is] ISSN:1532-3102
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Placenta previa is a condition in which the placenta implants in the poorly vascularized lower uterine segment, which may result in inadequate uteroplacental perfusion, in turn, adversely affect the neonatal outcome. Abnormal placentation may also lead to severe postpartum hemorrhage as placenta separation proceeds. We aimed to evaluate the differences in placental histopathology and perinatal outcomes in pregnancies complicated with placenta previa and controls. METHOD: We undertook a retrospective case-control study of 93 pregnancies with placenta previa and 81 controls between 2011 and 2017. RESULTS: Gross findings of the placenta showed that the placentas in placenta previa had significantly higher mean large chorionic plate diameters (18.5 ±â€¯3.2 vs 17.5 ±â€¯2.6 cm, P = .0298), chorionic plate areas (218.4 ±â€¯62.9 cm vs 198.7 ±â€¯56.0 cm , P = .0344), and marginal cord insertion (19.8% vs 8.6%, P = .0411) than control groups. Placental histopathological findings showed that placentas in placenta previa was significantly associated with maternal underperfusion, including villous infarction (50.5% vs 25.9%, P = .0009) and increased intervillous fibrin deposition (38.7% vs 7.4%, P < .0001). Also, women in the placenta previa group had a higher rate of abnormally invasive placenta and severe postpartum hemorrhage. However, placenta previa was not associated with the increased risk of neonatal mortality and morbidity. DISCUSSION: Abnormal placentation into the poorly vascularized lower uterine segment induces compensatory placental growth and increased surface area in response to reduced placental perfusion, which was consistent with the histopathological findings of coagulative necrosis of chorionic villi and fibrin deposition in the intervillous space. The morphological changes occurring in placenta previa may have important roles in maintaining adequate uteroplacental-fetal perfusion, which may prevent adverse neonatal outcomes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review

  7 / 3029 MEDLINE  
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[PMID]: 29481427
[Au] Autor:Markley JC; Farber MK; Perlman NC; Carusi DA
[Ti] Title:Neuraxial Anesthesia During Cesarean Delivery for Placenta Previa With Suspected Morbidly Adherent Placenta: A Retrospective Analysis.
[So] Source:Anesth Analg;, 2018 Feb 23.
[Is] ISSN:1526-7598
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: General anesthesia (GA) is often selected for cesarean deliveries (CD) with placenta previa and suspected morbidly adherent placenta (MAP) due to increased risk of hemorrhage and hysterectomy. We reviewed maternal outcomes and risk factors for conversion to GA in a cohort of patients undergoing CD and hysterectomy under neuraxial anesthesia (NA). METHODS: We performed a single-center, retrospective cohort study of parturients undergoing nonemergent CD for placenta previa with suspected MAP from 1997 to 2015. Patients were classified according to whether they received GA, NA, or intraoperative conversion from NA to GA. The primary outcome measure was postoperative acuity, defined as the need for intensive care unit admission, arterial embolization, reoperation, or ongoing transfusion with ≥3 units packed red blood cells. We additionally identified variables positively associated with intraoperative conversion from NA to GA during hysterectomy. Confounding was controlled with logistic regression models. RESULTS: Of 129 patients undergoing nonemergent CD for placenta previa with suspected MAP, 122 (95%) received NA as the primary anesthetic. NA was selected in the majority of patients with a body mass index ≥40 kg/m (9 of 10, 90%), a history of ≥3 prior CDs (18 of 20, 90%), suspected placenta increta or percreta (29 of 35, 83%), and Mallampati classification ≥3 (19 of 21, 90%). Of 72 patients with NA at the time of delivery who required hysterectomy, 15 (21%) required conversion to GA intraoperatively. Converted patients had a higher rate of major packed red blood cell transfusion (60% vs 25%; P = .01), with similar rates of massive transfusion (9% vs 7%; P = 1.0). Converted patients also had a higher incidence of postoperative acuity (47% vs 4%; P < .0001), including 5 intensive care unit admissions for airway management after large-volume resuscitation. After adjusting for multiple confounders, the only independent predictors of conversion among hysterectomy patients were longer surgical duration (adjusted odds ratio 1.54, 95% CI, 1.01.2.42) and a history of ≥3 prior CDs (adjusted odds ratio, 6.45; 95% CI, 1.12.45.03). CONCLUSIONS: NA was applied to and successfully used in the majority of patients with suspected MAP. Our findings support selective conversion to GA during hysterectomy in these patients, focusing on those with the highest levels of surgical complexity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher
[do] DOI:10.1213/ANE.0000000000003314

  8 / 3029 MEDLINE  
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[PMID]: 29469945
[Au] Autor:Duzyj CM; Buhimschi IA; Laky CA; Cozzini G; Zhao G; Wehrum M; Buhimschi CS
[Ad] Address:Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers University Robert Wood Johnson School of Medicine, 125 Paterson St, New Brunswick, New Jersey, 08901.
[Ti] Title:Extravillous trophoblast invasion in placenta accreta is associated with differential local expression of angiogenic and growth factors: a cross sectional study.
[So] Source:BJOG;, 2018 Feb 22.
[Is] ISSN:1471-0528
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Placenta accreta is clinically associated with maternal uterine scar. Our objective was to investigate the biochemical contribution of maternal scarring to hyperinvasive trophoblast. We hypothesized that trophoblast over-invasion in placenta accreta is associated with aberrant invasion-site signaling of growth and angiogenic factors known to be involved in wound healing and promotion of cell invasion through the epithelial to mesenchymal cellular program. DESIGN: Cross-sectional series. SETTING: Yale New Haven Hospital. POPULATION: Women with histologically confirmed normal and abnormal placentation. METHODS: Placental invasion site tissue sections were immunostained for endoglin, and other angiogenic regulators, and transforming growth factor ß (TGFß) proteins. Maternal serum endoglin, and the vascular endothelial growth factor (VEGF) mediators hypoxia inducible factor-1α (HIF1α) and endostatin, were assessed using immunoassay. MAIN OUTCOME MEASURES: Differences in median H-score by immunostain, and in mean serum level by immunoassay. RESULTS: By immunostaining, placenta accreta samples demonstrated intervillous endoglin shedding and increased trophoblast expression of its cleavage protein matrix metalloproteinase-14. Absent decidual HIF1α and endostatin were observed in areas of VEGF upregulation. TGFß1 was present in myocytes, but not in collagen bundles into which accreta trophoblast invaded. Maternal serum endoglin decreased in previa and accreta when corrected for gestational age. CONCLUSION: Angiogenic and growth factors at the placental invasion site are altered in accreta, both by decidual absence and within myometrial scar. We postulate this promotes the invasive phenotype of placenta accreta by activating hyperinvasive trophoblast, and by dysregulating placental vascular remodeling. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:Publisher
[do] DOI:10.1111/1471-0528.15176

  9 / 3029 MEDLINE  
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[PMID]: 29374881
[Au] Autor:Wei DM; Zhang ZZ; Wang Z; Li P; Wang JF; Liu YJ; Zhang JT; Shi YH
[Ad] Address:Reproductive Endocrinology Department, The Center for Reproductive Medicine, Shandong University, Jinan 250021, China.
[Ti] Title:[Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;53(1):18-22, 2018 Jan 25.
[Is] ISSN:0529-567X
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To compare the difference in risks of obstetric complications of singleton pregnancy between women with hyperandrogenic polycystic ovary syndrome (PCOS) and women with normoandrogenic PCOS. Prospective cohort study. This study was a secondary analysis of data collected during a multicenter randomized controlled clinical trial. Women who got clinical singleton pregnancy were grouped according to whether they were diagnosed with hyperandrogenism at baseline. There were 118 women with hyperandrogenism and 366 women without hyperandrogenism. The incidences of obstetric complications and birth weight were compared between the two groups. Women with hyperandrogenic PCOS had a significantly higher risk of preterm delivery than women with normoandrogenic PCOS [12.7% (15/118) versus 3.6% (13/366); 3.94, 95% 1.82-8.56]. After adjustment of age, duration of infertility, body mass index, and fresh or frozen embryo transfer group, hyperandrogenism was still associated with an increased risk of preterm delivery ( 3.67, 95% 1.67-8.07). Compared with women with normoandrogenic PCOS, women with hyperandrogenic PCOS had similar risks of pregnancy loss, gestational diabetes mellitus, pre-eclampsia, placenta previa, and postpartum hemorrhage (all 0.05). Birth weight as well as the risks of being small for gestational age and large for gestational age were also comparable between the two groups (all 0.05). In women with PCOS and singleton pregnancy, those with preconceptional hyperandrogenism have a higher risk of preterm delivery than those without hyperandrogenism.
[Mh] MeSH terms primary: Birth Weight
Hyperandrogenism/epidemiology
Polycystic Ovary Syndrome/epidemiology
Premature Birth/epidemiology
[Mh] MeSH terms secundary: Abortion, Spontaneous/epidemiology
Body Mass Index
Diabetes, Gestational/epidemiology
Female
Fertilization in Vitro
Gestational Age
Humans
Infant, Newborn
Infant, Small for Gestational Age
Pre-Eclampsia/epidemiology
Pregnancy
Pregnancy Complications/epidemiology
Prospective Studies
[Pt] Publication type:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Entry month:1802
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[Js] Journal subset:IM
[Da] Date of entry for processing:180129
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567X.2018.01.005

  10 / 3029 MEDLINE  
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[PMID]: 29331236
[Au] Autor:Sha T; Yin X; Cheng W; Massey IY
[Ad] Address:Department of Epidemiology and Medical Statistics, Xiangya School of Public Health, Central South University, Hunan, People's Republic of China.
[Ti] Title:Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis.
[So] Source:Fertil Steril;109(2):330-342.e9, 2018 Feb.
[Is] ISSN:1556-5653
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To provide an updated comparison of pregnancy-related complications and adverse perinatal outcomes of pregnancies conceived after frozen embryo transfer (FET) versus fresh embryo transfer (fresh ET). DESIGN: Meta-analysis. SETTING: University. PATIENT(S): Pregnancies resulting from FET versus fresh ET. INTERVENTIONS(S): Pubmed, Embase, Cochrane Library, Google Scholar, and Chinese databases, including the China National Knowledge Infrastructure Database, Wanfang, and Chinese Scientific Journals Full-Text Database were searched by two independent reviewers from January 1980 to September 2017. The results were expressed as risk ratios with 95% confidence intervals. MAIN OUTCOME MEASURE(S): Pregnancy-related complications and perinatal outcomes. RESULT(S): Our search retrieved 1,397 articles, of which 31 studies were included. Pregnancies resulting from FET were associated with lower relative risks of placenta previa, placental abruption, low birth weight, very low birth weight, very preterm birth, small for gestational age, and perinatal mortality compared with fresh ET. Pregnancies occurring from FET were associated with increased risks of pregnancy-induced hypertension, postpartum hemorrhage, and large for gestational age compared with fresh ET. The risks of gestational diabetes mellitus, preterm premature rupture of the membranes, and preterm birth (PTB) showed no differences between the two groups. CONCLUSION(S): Our analysis demonstrated that FET results in lower risks of placenta previa, placental abruption, low birth weight, very low birth weight, very preterm birth, small for gestational age, and perinatal mortality than fresh ET, some differences that are attributed to the increased risks of pregnancy-induced hypertension, large for gestational age, and postpartum hemorrhage. Although cryotechnology keeps improving, for comprehensive consideration, individual approaches remain appropriate to balance the options of FET or fresh ET at present.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[St] Status:In-Data-Review


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